data requirements for field release and monitoring jon knight imperial college london...
TRANSCRIPT
Data Requirements for Field Release and Monitoring
Jon KnightImperial College London
Overall Aim
• Guidance on standardised procedures for data collection and a structure to collect and access data to support best practice for monitoring and management of field release and deployment
Why collect data?• Inform target groups – policy makers,
researchers, programme managers, regulators, stakeholders
• Support objective – provide supporting data for risk assessment and project management from project initiation to maturity
• Address risk perception of various groups at relevant times
Key Phases• Project initiation – baseline data• Project implementation – real time data
collection for decision making• Project operation – continued monitoring for
safe and efficient operation of project• Long term monitoring – continued monitoring
to ensure impacts are maintained and that risk management is appropriate
Ethics Review
Ethics Review
EIA
Impact Evaluation
Genetic Data Population Data Release Area Data Operational Protocols Efficacy and Impact
Genetic Modification• Modification• Experimental protocol• Source of genetic materialPhenotypic effectsStability of construct
Genetic stabilityExtent of gene drive
Wild mosquito population• Baseline dataHuman context• Socioeconomic/cultural• Health (disease incidence or threat)• Risk perception/acceptanceEnvironmental conditions• Non-target organisms• Endangered or protected sites
Field release plansMonitoring plansFacility biosecurityStandard Operating Procedures • Production protocol• Contingency plans
Options for monitoringEfficacy of option chosenMechanism for ongoing data reviewModels for predictive monitoring scale and location, adjustment to real data
Phenotypic stabilityLife tables and fitnessMating competitivenessRate of Introgression
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Genetic Data Population Data Release Area Data
Operational Protocols
Efficacy and Impact
Pilo
t Pro
gram
me
Mai
nten
ance
Fiel
d Tr
ials
Labo
rato
ry
Confi
ned
Tria
ls
Ethics Review
EIAImpact
Evaluation
• Understand the target vector- Vector species presence- Vector density and abundance- Vector distribution (GPS)- Habitat
Baseline data
Baseline data• Health & Socio-economic indicators– Number of people in area, age, earnings, etc
• Epidemiology– Incidence of disease– Distribution of disease
• Perceptions of people– Disease– Control methods
• Vectors• Medicines
Baseline data
• Current control methods– Location of activities– Types of activities– Cost of activities (and who is paying)
• Current biodiversity– Ecosystem services
Project implementation
• Insect vector monitoring– Monitoring of modified insects• Apparent density and survival• Mobility and dispersal• Dispersion (niche occupation)• Persistence of gene in environment• Other biosafety indicators
– Monitoring of wild types• As above
Project implementation
• Monitoring and surveillance in and around production facility (escapes for sterile forms)
• Most of the above require reliable and quantifiable trapping systems
• Epidemiology
Project Operation• Monitoring insect numbers (direct sampling)• Monitoring disease incidence (indirect)• “Success” of programme– Sampling and detection of transgene in target insect
population– Establishing absence of vectors
• Recording of production and release costs• Monitoring and surveillance in and around
production facility (escapes for sterile forms)
Long term monitoring
• Trapping network for detecting reinvasion• Disease prevalence monitoring
• If continued releases– Ensure impacts continue (strain still effective)
Long term monitoring • Acquisition of a new and undesirable
capability/behaviour– increased capacity to transmit a pathogen– increased blood-feeding frequency, altered host
preference• Disruption of any essential or beneficial function– food chain in some environments, etc
• Reproductive effects in a non-target organism– sterility, mutations, etc
• Alteration or disruption of normal interactions of organisms in the environment (ecosystem effects)
Data management• Deliver timely information to decision makers– Clear data recording and reporting structures– Standardised data sheets– Geo-referencing of data (where appropriate) – Spatial data stored in a Geographic Information
System (GIS) facilitating rapid mapping– Compilation in standard structures within Excel,
Access, etc• Data analysis at regular intervals relevant to the
project
Thank you
Any questions?¿Preguntas?