DANIEL PRICE Tel: 00447827968483

E-mail: danjosephprice@gmail.comNationality: British

Date of Birth: 31st January 1994

PERSONAL PROFILE

A highly motivated, inquisitive and enthusiastic scientist with an outstanding academic record and valuable research experience within industry and academia in addition to a varied collection of communication and interpersonal skills. Experienced and competent with synthetic and medicinal chemistry; polymer sciences; pharmaceutical sciences and a variety of analytical techniques and processes. Past research experience includes: elucidating the structure of G-Protein Coupled Receptors (GPCR); investigating novel research formulations for poorly soluble compounds in pre-clinical and clinical development; assessing the utility of various in vitro characterization assays and development of biodegradable co-polymer systems with controlled and targeted drug delivery capabilities.

EDUCATION AND QUALIFICATIONS

September 2012- Present University of Leeds Leeds, UK Master and Bachelor of Science (MChem, BSc) Medicinal Chemistry Expected Grade: 1st Class (1:1) (4.0 GPA)

August 2010-May 2012 Dulwich College Shanghai Shanghai, China International Baccalaureate Diploma Grade: 36 (Chemistry HL 7, English HL 7, Mathematics SL 7, Spanish SL 6, Psychology HL 5,

Biology HL 6)

September 2005-May 2010 Maricourt Catholic High School Liverpool, UK GCSE Grade: 10xA* including mathematics, English and sciences

RELEVANT EXPERIENCE

September 2015-Current University of Leeds School of Chemistry, Leeds, UK MChem Research Student

Research student in the lab of Dr Paul Thornton, investigating the synthesis of biodegradable polymers used for controlled-release (CR) drug delivery purposes.

Utilizing N-carboxyanhydride (NCA) and O-carboxyanhydride (OCA) ring opening polymerisation (ROP) techniques under Schlenk conditions to produce novel polypeptides and poly-esters respectively.

Formation of polypeptide-polyester block co-polymers capable of self-assembly to encapsulate drug molecules

Investigating the feasibility of N-thiocarboxyanhydride (ROP) for synthesis of biocompatible polymers useful for drug delivery

Use of various analytical techniques includingː ultra-high-performance liquid chromatography (UPLC); gas permeation chromatography; nuclear magnetic resonance; dynamic light scattering and scanning electron microscopy.

September 2014-September 2015 Pfizer, Ltd Cambridge, UK Formulation Industrial Trainee

Investigated mesoporous silica as a potential excipient to increase the oral bioavailability of orally delivered drugs

Designed and performed novel biorelevant dissolution assays to screen the potential of novel formulation enhancement technologies.

Assessed the importance of prandial-state simulation during the in vitro physiochemical and dissolution screening of pre-clinical drug candidates

Experienced with ‘transfer-dissolution’ models for enhanced in vitro-in vivo correlations Optimized a mesoporous silica-precipitation inhibitor system for optimal dissolution enhancement

of poorly soluble drugs Designed and optimized a novel loading procedure for adsorption of active pharmaceutical

ingredient (API) on to mesoporous materials, resulting in a 94% reduction in total loading time compared to previous techniques. This was achieved whilst still maintaining high dissolution performance

Chaired global data sharing meetings and organised collaboration with external and internal parties

Regularly presented data within the company with a high level of presentation, which spurred an increased interest in mesoporous silica technology across the company

Adept with both solubility and stability screening procedures and technologies Expert user in high-performance liquid chromatography (HPLC), Empower, powder x-ray

diffraction (PXRD), polarised light microscopy (PLM). Collaborated with in vivo and pharmacokinetics experts to design a successful rat pre-clinical trial Member of medicinal chemistry design meetings Lab stock manager responsible for day-to-day lab stocking as well as external capital purchasing

and risk assessment Instilled a legacy for the potential use of mesoporous silica with upcoming pre-clinical candidates

July 2012-August 2012 Shanghai Institute of Materia Medica Shanghai, China Research Intern

Molecular biology based lab project to try to elucidate the structure of the GPCR LGR-4 Adept at various molecular biological techniques: cell culturing, protein expression analysing

protein conjugates, SDS page gel electrophoresis and crystallisation Exposed to the workings of an academic research environment

OTHER RELEVANT TRAINING AND SKILLS

Possess a wide toolbox of synthetic techniques from undergraduate chemistry labs Home office certified radiation user for X-ray crystallography

ACHEIVEMENTS AND ACTIVITIES

University of Leeds student ambassador for the Royal Society of Chemistry, 2013 Medicinal chemistry course rep, 2013 Social Secretary, Leeds University Skydiving, 2013 Academic prefect, Dulwich College Shanghai, 2011-2012 Research Scholarship, Shanghai Institute of Materia Medica, 2012