MIL ANO | ITALYIstituto Ganassini S.p.A. di Ricerche Biochimiche, Via P. Gaggia 16 - 20139 Milano - www.rilastil.com

D-CLARD-CLAR

INTENSIFIES THE EFFICACY OF PEELING/LASER TREATMENT FOR

HYPERPIGMENTATION

For physician use onlyFor physician use only

RILASTIL D-CLAR

A study on 2,823 adults (average age of 49 years) has highlighted that the prevalence of lentigo solaris is of 62,4%, while that of lentigo senilis is of 33,2%.*

*The Epidemiology of Nevi and Signs of Skin Aging in the Adult General Population: Results of the KORA-Survey 2000, T. Schafer et al., Journal of Investigative Dermatology (2006), Volume 126, 1490-1496

LENTIGO SOLARIS LENTIGO SENILIS POST-INFLAMMATORY HYPERPIGMENTATION

MELANIN CYCLE PHASES

PREVALENCE OF HYPERPIGMENTATION

The optimal topical treatment to contrast and prevent hyperpigmentation should act on every phase of the melanin cycle.

1st P

HA

SE

2nd

PH

AS

E3

rd P

HA

SE

4th P

HA

SE ACCUMULATION OF

MELANIN IN THE CORNEOCYTES OF THE STRATUM CONRNEUM

TRANSPORT OF THE MELANIN FROM

MELANOCYTE TO KERATINOCYTE

OXIDATION OF THE COLORLESS MELANIN INTO DARK MELANIN

SYNTHESIS OF THE MELANIN INSIDE THE

MELANOCYTE

UVB UVA

For physician use only

Dermofarm Laboratorios. Barcelona, January, 2020.

Instrumental evaluation of the melanin index (SkinColorCatch®).

RILASTIL D-CLAR

CLINICAL STUDIES

RILASTIL D-CLAR DEPIGMENTING CONCENTRATE DROPS

REDUCTION OF THE SPOT’S INTENSITY

Panel: 30 volunteers with hyperpigmentation on face, neck and neckline (24-45 years old).

Treatment: two localized applications (morning and evening) on the hyperpigmentation for 56 days.

For physician use onlyFor physician use only

Rilastil D-Clar Depigmenting Concentrate Drops determine a statistically significant reduction of the

spot’s intensity by 18,7% in 56 days.

-18,7% of melanin in 56 daysStatistically significant results p<0.0001

-18,7%

Mel

anin

Inde

x

500

650

620

590

560

530

T56T28T0

Cod: P00X55110

Dermofarm Laboratorios. Barcelona, July 3, 2019

Instrumental evaluation of the melanin index (SkinColorCatch®).

RILASTIL D-CLAR CONCENTRATED MICROPEELING

REDUCTION OF THE SPOT’S INTENSITY

Panel: 20 volunteers with hyperpigmentation on face, neck, neckline and back of hands (32-72 years old).Treatment: one application per day for 56 days.

RILASTIL D-CLAR

For physician use only For physician use only

Rilastil D-Clar Concentrated Micropeeling determines a statistically significant reduction of the spot’s intensity by 9% in 56 days.

-9% of melanin in 56 daysStatistically significant results p<0.0001

-9%

Mel

anin

Inde

x

540

620

600

580

560

T56T28T0

Dermofarm Laboratorios. Barcelona, June 28, 2019

Instrumental evaluation of the melanin index (SkinColorCatch®).

RILASTIL D-CLAR DAILY DEPIGMENTING CREAM

REDUCTION OF THE SPOT’S INTENSITY

Panel: 20 volunteers with hyperpigmentation on face, neck and neckline (27-69 years old).Treatment: two applications (morning and evening) on the whole area affected by the hyperpigmentation (face, neck, neckline) for 56 days.

Rilastil D-Clar Daily Depigmenting Cream determines a statistically significant reduction of the spot’s intensity by 10,8% in 56 days.

-10,8% of melanin in 56 daysStatistically significant results p<0.0001

-10,8%

Mel

anin

Inde

x

540

600

620

580

560

T56T28T0

Mandelic Acid

10%

anti-spot ingredients

5,2%

Hydroxyresveratrol NiosomeClari-tech Complex (Tetrapeptide-30, High Tech Vitamin C, Niacinamide)

Depigmenting

Hyaluronic Acid Hydrating

Vitamin E Soothing

ACTIVE INGREDIENTS ACTIONS

Istituto Ganassini S.p.A. di Ricerche Biochimiche, Via P. Gaggia 16 - 20139 Milano - www.rilastil.com

ANTI-DARK SPOT TREATMENT

RILASTIL D-CLAR

40 ml

RILASTIL D-CLAR DAILY DEPIGMENTING CREAMDaily depigmenting, illuminating and uniforming treatment.

RILASTIL D-CLAR CONCENTRATED MICROPEELINGBiphasic milk with intensive exfoliating action.The texture with lipidic fraction restores the skin comfort.

100 ml

Mandelic Acid 10%Liposomal Tripeptide Exfoliating

Bisabolol Soothing

ACTIVE INGREDIENTS ACTIONS

For physician use only

Hydroxyresveratrol NiosomeClari-tech Complex (Tetrapeptide-30, High Tech Vitamin C, Niacinamide)4-Butylresorchinol

Depigmenting

Fruit AHA Liposomal Tripeptide Exfoliating

Sodium DNA Elasticizing

Peony extract Soothing

ACTIVE INGREDIENTS ACTIONS

RILASTIL D-CLAR DEPIGMENTING CONCENTRATE DROPSLocalized depigmenting shock treatmentActive on every stage of the melanin cycle

ENHANCED FORMULA WITH HYDROXYRESVERATROL NIOSOME

anti-spot ingredients

13,7%

30 ml

1

2

3

Hydroxyresveratrol NiosomeClari-tech Complex (Tetrapeptide-30, High Tech Vitamin C, Niacinamide)

Depigmenting

Hyaluronic Acid Hydrating

Vitamin E Soothing Istituto Ganassini S.p.A. di Ricerche Biochimiche, Via P. Gaggia 16 - 20139 Milano - www.rilastil.com

RILASTIL D-CLAR

HOW TO USE

DEPIGMENTING CONCENTRATE

DROPS

MORNING

CONCENTRATED MICROPEELING

++DAILY

DEPIGMENTING CREAM

DEPIGMENTING CONCENTRATE

DROPS

+

For physician use onlyFor physician use only For physician use only

UNIFORMING AND DEPIGMENTING CREAM

SPF 50+

1 2 3

EVENING

0*Except for D-Clar Daily Depigmenting Cream

FRAGRANCE*WHEAT DERIVATIVES

Co

d: P

00

X55

110

- 0

220