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CURRICULUM VITAE

Cynthia B. Peterson, Ph.D.Department of Biochemistry and Cellular and Molecular BiologyThe Center of Excellence in Structural BiologyProgram in Genome Science and Technology

The University of Tennessee Telephone: (865)974-4083; FAX: (865)974-6306M407 Walters Life Sciences Building E-mail address: [email protected], TN 37996 Web Page: http://web.bio.utk.edu/peterson

Personal Home Address: 4516 Eutaw PlaceKnoxville, TN 37919Telephone: (865)673-8203

Born: November 9, 1957Baton Rouge, LA

Education Ph.D., Biochemistry (May, 1986)Louisiana State University Medical CenterShreveport, LA

M.S., Biochemistry (May, 1981)Louisiana State University Medical CenterShreveport, LA

B.S., Biochemistry (May, 1979)Louisiana State UniversityBaton Rouge, LAGraduated Magna Cum Laude

Research Interests

Research activities are focused on understanding the structure and function of vitronectin, an abundant protein in the blood that regulates many physiological processes. Circulating vitronectin associates with tissue matrices, and its presence is important in pathological situations or in cancer metastasis and tissue remodeling. The factors that control the binding interactions and determine activities of vitronectin in the circulation as well as in the matrix are important unsolved issues. Approaches that encompass a wide spectrum of biophysical and cellular and molecular biological techniques are used to approach important questions regarding the specificity of interaction of vitronectin with many of its biological targets.

Key Words: Coagulation, Fibrinolysis, Serpins, Vitronectin, Cell Adhesion, Heparin Expertise: Hydrodynamics, Analytical Ultracentrifugation, Fluorescence Spectroscopy, Calorimetry, Cell Culture, Expression of Recombinant Proteins, Baculovirus Technology

Teaching Emphases Protein Structure and FunctionModern Techniques in Biochemistry and BiotechnologyThe Specificity and Energetics of Macromolecular Interactions

CURRICULUM VITAE, Cynthia B. Peterson, Ph.D. p. 2

Work Experience

March, 2005 – present Associate DirectorProgram in Genome Science and Technology University of Tennessee, Knoxville, TN

August, 2002 - present ProfessorDepartment of Biochemistry and Cellular and Molecular BiologyUniversity of Tennessee, Knoxville, TN

June, 2001 - Associate DirectorDecember 2003 Center of Excellence in Structural Biology

University of Tennessee, Knoxville, TN

August, 1997- Associate ProfessorJuly, 2002 Department of Biochemistry and Cellular and Molecular Biology


January, 1992- Assistant ProfessorJuly, 1997 Department of Biochemistry and Cellular and Molecular Biology


1987-1991 Postdoctoral Fellow with Professor H. K. Schachman Department of Molecular and Cell Biology and Virus LaboratoryUniversity of California, Berkeley, CA

1986-1987 Postdoctoral Fellow with Professor Michael N. BlackburnDepartment of Biochemistry and Molecular BiologyLouisiana St. Univ. Medical Center, Shreveport, LA

1980-1986 Graduate Student with Professor Michael N. BlackburnDepartment of Biochemistry and Molecular BiologyLouisiana St. Univ. Medical Center, Shreveport, LA

Spring, 1979 Laboratory Instructor, Undergraduate General Chemistry LabLouisiana State University, Baton Rouge, LA

Honors

Phi Beta KappaPhi Kappa PhiLSU Alumni Association "Top 100" Scholarship, 1975-1979Who's Who Among American Colleges and Universities, 1979Kontes Scholarship, W. Alton Jones Cell Science Center, 1981First Place, 1985 Student Research Forum, LSU Medical CenterChancellor's Award, Commencement, May, 1986XIth International Society of Thrombosis and Haemostasis Congress Award, July, 1987, Brussels, BELGIUMNational Research Service Award, NIH, July, 1987 - October, 1990Travel Award, Gordon Conference on Thrombosis, March, 1994, Ventura, CAScience Alliance Faculty Research Award, University of Tennessee Center of Excellence,

1994, 1995, 1996, 1997, 1998, 1999, 2000, 2001Established Investigator Award, American Heart Association, July 1, 1995 to June


30, 2000 Phi Beta Kappa Certificate of Merit, Natural Sciences Division, University of

Tennessee, April, 1997Finalist, 1998 Cardiovascular Research Prize, Council on Circulation, American

Heart Association, Lake Tahoe, CA, February 23, 1998Finalist and Winner, 1998 YWCA Tribute to Women, Science and Technology

Category, November, 1998, Knoxville, TNFeatured Faculty by Provost Loren Crabtree, recognized on the university website for the month of

October, 2002 (http://provost.utk.edu/featured/sep02.shtml)Featured in ITC Spotlight in recognition of use of web-interactive resources in teaching, April/May, 2003

(http://itc.utk.edu/showcase/spotlight/peterson/default.shtml)

External Support for Research (PI on all grants/support listed unless otherwise specified)

National Institutes of Health, National Heart, Lung and Blood Institute, competitive renewal of Grant No. 2R01HL50676, “Macromolecular Interactions of Human Vitronectin,” July, 2003 - May, 2007; $1, 040,000

National Institutes of Health Research Grant No. 2R01HL50676, “Macromolecular Interactions of Human Vitronectin,” December, 1998 - November, 2002; $549,769.

Grant-in-Aid, American Heart Association, Southeast Regional Affiliate, Ref. No. 0151052B, “Use of Analytical Chemistry and Computational Biology to Determine Structure of Vitronectin Domains,” July, 2001- June, 2003, $120,000.

Established Investigator Award, American Heart Association, "The Role of Vitronectin and Its Interactions In Hemostasis," July, 1995-June, 2000; $265,000.

National Institutes of Health FIRST Award, “Macromolecular Interactions with Human Vitronectin,” August, 1993-July, 1997; $262,750 (direct costs).

American Heart Association, Tennessee Affiliate, New Investigator Award, “Regulation in Hemostasis by Vitronectin,” July, 1993-June, 1995; $80,000. Terminated August 1, 1993 by the principal investigator due to scientific overlap upon initiation of the NIH grant.

National Research Service Award, National Institutes of Health, “Reversion of a pyrB Mutant with Improper Folding, “July, 1987-October, 1990.

American Cancer Society Postdoctoral Fellowship, July, 1987-June 1989, awarded, but not accepted by the applicant because of overlap with the NIH award.

J. Walter Libby Postdoctoral Fellowship, American Heart Association, Louisiana, Inc., “Modulators of Heparin Anticoagulant Activity,” 1986-1987.

Student Grant-in-Aid, American Heart Association, Louisiana, Inc., “Critical Lysines in Antithrombin,” 1985-1986.

Pending Grant Applications

National Institutes of Health, NCRR Shared Instrumentation Grant Program, “NMR Coldprobe for the East Tennessee Area.” PI: Nitin Jain, Co-PI’s: Cynthia B. Peterson, Ronald Wetzel, Engin Serpersu, David Baker, Elias Fernandez, and Tanya Kuritz; Submitted April 1, 2005; $326,500.


National Institutes of Health, R21 Exploratory/Development Grant, “Effects of Tissue-Type Plasminogen Activator on the Mammalian Circadian Clock.” PI: Rebecca A. Prosser, Co-PI: Cynthia B. Peterson; Submitted June 1, 2005; $389,085.

National Science Foundation, Proposal No. 05443644, “Characterizing Higher Order Complexes of Vitronectin“, PI: Cynthia B. Peterson, Submitted July 12, 2005; $455,357.

Other External Support

Laboratory Director’s Research and Development Fund for Functional Genomics, ORNL/matching funds from the University of Tennessee, “Pilot Study to Develop Phenotypic Screens for Sperm Aneuploidy and Levels of Fibrinolytic Proteins,” March, 1999 – February 2001; Co-Principal Investigators: Mary Ann Handel and Cynthia B. Peterson. This pilot project was funded to evaluate the utility and suitability of immunoassays to quantify levels of fibrinolytic proteins as a part of a large-scale phenotypic screening effort of the Tennessee Mouse Genetics Consortium. Dr. Peterson’s responsibility being the immunoassays for fibrinolytic proteins, and Dr. Handel’s role involving screens for chromosome segregation. The funds have been used to hire a technician to carry out the screens and to buy an ELISA plate reader with fluorescence capabilities.

Howard Hughes Medical Institute, "Threshold Program in the Biological Sciences," October, 1994-October 1998. Applicant: Frank W. Harris, Director of Biology. Co-Applicant: Neil Greenberg. Participants: Jeff Becker, Rod Bunn, David, Fox, Jim Lawler, Beth Mullin, Bruce McKee, Denny Mullins, Gerald Vaughan, Bruce DeLaney, John Dunlap, John Gittleman, Lou Gross, Mary Ann Handel, Liz Howell, Ed Howley, Lee Humphreys, Faye Julian, Mike Keene, John Koontz, Sandra Leach, Mark Littmann, Deborah McCleary, Ron McFadden, Greta McMillan, Bob Meunchen, Mike Pelton, Cynthia Peterson, Rebecca Prosser, Susan Riechert, Gary Stacey, and Pete Wicks. This grant was given to the institution for development of outreach programs to stimulate and encourage interest in biological research among the undergraduate population. The total sum of the grant over the four years was over a million dollars.

National Institutes of Health Small Equipment Grant, July 1, 1994; with matching funds from the College of Liberal Arts and the Department of Biochemistry the award totaled $29,419; for purchase of a MicroCal OMEGA Titration Calorimetry Accessory for the MC-2D Scanning Calorimeter housed in the laboratory of Dr. Peterson. Applicant: Frank W. Harris, Director of Biology. Co-Investigators: Cynthia B. Peterson, Elizabeth E. Howell, and Engin S. Serpersu.

Internal Support

Professional Development Award, University of Tennessee, “Evaluating the Therapeutic Potential of Vitronectin as a Drug Target.” November, 2004, $5000.

SARIF Exhibit, Performance, and Publication Expense Award, UTK Office of Research and the Faculty Senate Research Council, September, 2004, award to cover partial cost for publication of an article in the Journal of Biological Chemistry, $1000.

SARIF Exhibit, Performance, and Publication Expense Award, UTK Office of Research and the Faculty Senate Research Council, July, 2004, award to cover half of the cost for publication of an article in the Journal of Biological Chemistry, $1000.

Travel Grant, Office of Research, University of Tennessee, to attend XVIIth International Congress on Fibrinolysis and Proteolysis in Melbourne, Australia. March 21-25, 2004. $5800.


Pilot Project Grant, Center of Excellence in Structural Biology, University of Tennessee, “The Role of Metals in Vitronectin Structure and Function,” Co-PIs: Cynthia B. Peterson and Engin Serpersu, July, 2003-June, 2004, $10,000.

Neutron Sciences Fellowship; UT program offered through the NSF-funded International Materials Institute the Tennessee Advanced Materials Laboratory and the Joint Institute for Neutron Sciences; PI: Cynthia Peterson; Graduate Fellow: Cindy Brown; July, 2003-June, 2004; $11,000.

Collaborative Research Grant, Center of Excellence in Structural Biology, University of Tennessee, “Structural Studies on Human Vitronectin,” PI: Cynthia Peterson; Collaborators: Chris Dealwis, Gary Lynn, Oakley Crawford, December, 2002-November, 2003; $40,000.

Professional Development Award, University of Tennessee, “Microarray Analysis of Vitronectin Knockout Mouse.” April, 2002, $5000.

Faculty First 2002 Award. Grant from ITC for continued development of web-based resources to accompany BCMB 515 for Fall, 2002; December, 2001 – August, 2002; $2000.

Collaborative Research Grant, Center for Genomics and Bioinformatics, University of Tennessee, “Molecular Characterization of Mouse Models—Links Between Obesity, Diabetes and Cardiovascular Disease,” PI: Cynthia B. Peterson; Co-PI: Naima Moustaid-Moussa, November, 2001-October, 2002, $25,000.

Matching funds for purchase of Beckman Model XL-I Analytical Ultracentrifuge received from the Center of Excellence in Structural Biology, SARIF, the College of Arts and Sciences, the Department of Biochemistry and Cellular and Molecular Biology, the Department of Chemistry, the Program in Genome Science and Technology, the Materials Council at UTK, UT Medical Center at Knoxville, and various individuals, July, 2001. Total purchase: $285,633.

Professional Development Award, University of Tennessee, “Functional Genomics of Vitronectin Knockout Mouse,” 2001- 2002, $5000.

GST Postdoctoral Fellowship, University of Tennessee and Oak Ridge National Laboratory, “Microarray and Proteomics Analysis of Circulating Proteins in Mouse Blood,” November, 2000 – October, 2002, $20,000 per year, total of $40,000 from the GST program; matching funds were obtained from the Science Alliance at UT and the Division of Biology. Postdoctoral trainee for the duration of the award was Christine Schar.

SARIF Exhibit, Performance, and Publication Expense Award, UTK Office of Research and the Faculty Senate Research Council, July, 2000, award to cover half of the cost for publication of an article in the Journal of Biological Chemistry, $500.

Special Fund Allocation from the Division of Biology and the College of Arts and Sciences to sponsor an outreach project to all first grade classrooms in Knox County. This project was implemented in conjunction with the East Tennessee Discovery Center’s Butterfly Project, which provides kits to all first graders containing butterfly larvae for hands-on experience in metamorphosis of the insects. This award covered the cost of producing an educational video on butterfly development and habitat, April, 1999, $6000.

SARIF Exhibit, Performance, and Publication Expense Award, UTK Office of Research and the Faculty Senate Research Council, February, 1999, award to cover half of the cost for publication of an article in the Journal of Biological Chemistry, $668.


SARIF Exhibit, Performance, and Publication Expense Award, UTK Office of Research and the Faculty Senate Research Council, April, 1997, award to cover half of the cost for publication of an article in the Journal of Biological Chemistry, $325.

SARIF Exhibit, Performance, and Publication Expense Award, UTK Office of Research and the Faculty Senate Research Council, February, 1997, award to cover half of the cost for publication of an article in the Journal of Biological Chemistry, $673.

SARIF Exhibit, Performance, and Publication Expense Award, UTK Office of Research and the Faculty Senate Research Council, June, 1996, award to cover half of the

cost for publication of two papers in the Journal of Biological Chemistry, $782.50.

Special Equipment Support; a one-time request for special funds for the purchase of acontrol module to properly configure the Omega isothermal titration calorimeter separately from the MicroCal MC-2D differential scanning calorimeter. Funds were obtained from a variety of sources, including the Department of Biochemistry and Cellular and Molecular Biology, the Division of Biology, the College of Liberal Arts, the Science Alliance, and the Office of Research Administration. Funding of this project was coordinated by Dr. Frank Harris, with matching funds of $3000 from Cynthia B. Peterson and Elizabeth E. Howell. Total request: $26,000.

Professional Development Award, UTK Program for Tenure-Track Faculty, 1995-96, "Expression of a Recombinant Form of Human Plasma Vitronectin," $4300.

Faculty Research Award, University of Tennessee Professional Development Awards Program, 1994-95, "Expression and Characterization of Recombinant Human Vitronectin," $4200.

Biology Division, University of Tennessee, Equipment grant for the purchase of a fluorimeter, March, 1994; $19,500. Co-Applicants: Cynthia B. Peterson

and Daniel M. Roberts.

Biology Division, University of Tennessee Science Alliance, Equipment grant for the purchase of a stopped-flow instrument, March, 1993; $33,000. Applicant: Elizabeth E. Howell, Co-Investigators: Cynthia B. Peterson, Engin H. Serpersu, Jorge Churchich, Fred Hartman, and Solon Georgiou.

Ongoing Professional Collaborations

Dr. Naima Moustaid-Moussa, Associate Professor, Nutrition Department, College of Human Ecology, University of Tennessee, Knoxville, TN. Dr. Moustaid-Moussa is working with our laboratory on the characterization of mice as models for human disease. We are particularly interested in correlations between cardiovascular disease and obesity, and we are using genomics and proteomics methods to develop these relationships.

Dr. Peter Schuck, Protein Biophysics Resource, Division of Bioengineering and Physical Science, National Institutes of Health. The laboratory at the NIH is collaborating on hydrodynamic studies using the analytical ultracentrifuge with vitronectin. Sedimentation velocity experiments are being used to evaluate the mechanism of assembly of higher-order PAI-1/vitronectin complexes. Dr. Schuck is working with us on some cutting-edge analysis tools using multi-wavelength global fits to the data to evaluate stoichiometries of the complexes.

Dr. Greg Hurst, Analytical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN. The structure for vitronectin that has been predicted by the computational approaches is being corroborated by


work on the structure using mass spectrometry. A combination of traditional protein biochemistry using chemical/enzymatic cleavage and HPLC is currently being employed to identify the six disulfide bonds in vitronectin. The peptides that are disulfide cross-linked are identified by the unique mass identifier using mass spectrometry. In a similar fashion, the three-dimensional fold of vitronectin is being approached using chemical cross-linkers to define regions of the protein that come in close contact in the folded structure. The peptide mapping and mass spectrometry are used in this approach to identify amino acids that are in close proximity in the native three-dimensional structure.

Dr. Grant Blouse, Department of Biochemistry, Henry Ford Health System, Detroit, MI. The laboratory of at the Ford Health System has provided samples of plasminogen activator inhibitor-1 for evaluation of the energetics and specificity of vitronectin-PAI-1 interactions. Site-directed mutagenesis has been used to introduce unique sulfhydryls into PAI-1 which can, in turn, be labeled with a variety of fluorescent probes. The fluorophores provide a sensitive means to quantify interactions between vitronectin and PAI-1 and evaluate structural changes, which accompany the interaction.

Professional Affiliations

American Society for Biochemists and Molecular BiologistsAmerican Association for the Advancement of ScienceThe Protein SocietyAmerican Heart Association, Council on Arteriosclerosis, Thrombosis and Vascular BiologyInternational Society for Thrombosis and Proteolysis

Publications

Minor, K. H., Schar, C. R., Blouse, G. E., Shore, J. D., Lawrence, D. A., Schuck, P., and Peterson, C. B. (2005) J. Biol. Chem., 280, 28711-28720. “A Mechanism for Assembly of Complexes of Vitronectin and Plasminogen Activator Inhibitor-1 from Sedimentation Velocity Analysis.”

Lynn, G. W., Heller, W. T., Mayasundari, A., Minor, K. H., and Peterson, C. B. (2005) Biochemistry 44, 565-574. “A Model for the Three-Dimensional Structure of Human Plasma Vitronectin from Small Angle Scattering Measurements.”

Balbo, A., Minor, K. H., Velikovsky, C. A., Mariuzza, R. A., Peterson, C. B., and Schuck, P. (2005) Proc. Natl. Acad. Sci. USA 102, 81-86. “Studying Multi-Protein Complexes by Multi-Signal Sedimentation Velocity Analytical Ultracentrifugation.”

Horn, N. A., Hurst, G. B., Mayasundari, A., Whittemore, N. A., Serpersu, E. H., and Peterson, C. B. (2004) J. Biol. Chem. 279, 35867-35878. “Assignment of the Four Disulfides in the N-terminal Somatomedin B Domain of Native Vitronectin Isolated from Human Plasma.”

Mayasundari, A., Whittemore, N. A., Serpersu. E. H. and Peterson, C. B. (2004) J. Biol. Chem. 279, 29359-29366. “The Solution Structure of the N-terminal Domain of Human Plasma Vitronectin: Location of Binding Sites that Regulate Fibrinolysis and Cell Migration.”

Gupta, V., Peterson, C. B, Dice, L. T., Uchiki, T., Racca, J., Guo, J.-t, Xu, Y., Hettich, R., Zhao, X., Rothstein, R., and Dealwis, C. (2004) Biochemistry 43, 8568-8578. “Sml1p is a Dimer in Solution: Characterization of Denaturation and Renaturation of Recombinant Sml1p”

Minor, K. H., and Peterson, C. B. (2002) J. Biol. Chem. 277,10337-10345. “PAI-1 Promotes the Self-Association of Vitronectin into Complexes Exhibiting Altered Incorporation into the Extracellular Matrix.”


Podor, T. J., Campbell, S., Chindemi, P., Foulon, D. M., Farrell, D. H., Walton, P.D., Weitz, J. I., and Peterson, C. B. (2002) J. Biol. Chem. 277, 7520-7528. "Incorporation of Vitronectin into Fibrin Clots: Evidence for a Binding Interaction between Vitronectin and A/' Fibrinogen,"

Xu, D., Baburaj, K., Peterson, C. B., and Xu, Y. (2001) Proteins: Structure, Function and Genetics, 44, 312-320. “A Model for the Three-Dimensional Structure of Vitronectin: Predictions for the Multi-Domain Protein from Threading and Docking.”

Gibson, A. D., and Peterson, C. B. (2001) Biochim. Biophys. Acta, 1545, 389-403. “Full Length and Truncated Forms of Vitronectin Provide Insight into Effects of Proteolytic Processing on Function.”

Podor, T. J., Shaughnessy, S. G., Blackburn, M. N. and Peterson, C. B. (2000) J. Biol. Chem. 275, 25402-25410. “New Insights into the Size and Stoichiometry of the Vitronectin:PAI-1 Complex.”

Podor, T. J., Peterson, C. B., Lawrence, D. A., Stefansson, S., Stephen G. Shaughnessy, S. G., Foulon, D. M., Butcher, M., and Weitz, J. I. (2000) J. Biol. Chem. 275, 19788-19794. "Plasminogen Activator Inhibitor Binds to Fibrin via Vitronectin."

Gibson, A. D., Lamerdin, J. A., Zhuang, P., Baburaj, K., Serpersu, E. H. and Peterson, C. B.(1999) J. Biol. Chem. 274, 6432-6442. “Orientation of Heparin-Binding Sites in Native Vitronectin: Analyses of Ligand Binding to the Primary Glycosaminoglycan-binding Site Indicate that Putative Secondary Sites are Not Functional."

Peterson, C. B. (1998) Trends in Cardiovascular Medicine 8, 124-131. "Binding Sites on Native and Multimeric Vitronectin Exhibit Similar Affinity for Heparin: The Influence of Self-Association and Multivalence on Ligand Binding." (invited review).

Stebbins, M.A., Schar, C. R., Peterson, C. B., and Sepaniak, M. J. (1998) Biotechnology Laboratory, 16, 55-57. “Partial Digestion by Capillary Electrophoresis. A Facile Time Course Evaluation of DNA Restriction Digests." (invited article)

Sepaniak, M., Stebbins, M., Todd, A., Gibson, T., Peterson, C., and Diack, M. (1998) Pro. of SPIE-Soc. Opt. Eng. 3256, 162. “Size-Selective Capillary Electrophoresis Investigations of pET3aPAI-11 DNA Involving Restriction Digestion, Laser Induced Fluorescence Detection, and Micro-preparative Separation.”

Zhuang, P., Chen, A. I., and Peterson, C. B. (1997) J. Biol. Chem. 272, 6858-6867. "Native and Multimeric Vitronectin Exhibit Similar Affinity for Heparin. Differences in Heparin Binding Properties Induced upon Denaturation are Due to Self Association into a Multimeric Form."

Gibson, A.D., Baburaj, K., Day, D. E., Verhamme, I., Shore, J. D., and Peterson, C. B. (1997) J. Biol. Chem., 272, 5112-5121. "The Use of Fluorescent Probes to Characterize Conformational Changes in the Interaction Between Vitronectin and Plasminogen Activator Inhibitor-1."

Stebbins, M.A., Schar, C. R., Peterson, C. B., and Sepaniak, M. J. (1997) J. Chromatography B: (Biomedical Applications) 697, 181-188. "Temporal Analysis of DNA Restriction Digests by Capillary Electrophoresis."

Zhuang, P., Blackburn, M. N., and Peterson, C. B. (1996) J. Biol. Chem. 271, 14323-14332. "Characterization of the Denaturation and Renaturation of Human Plasma Vitronectin. I. Biophysical Characterization of Protein Unfolding and Multimerization."

Zhuang, P., Li, H., Williams, J. G., Wagner, N. V., Seiffert, D., and Peterson, C. B. (1996) J. Biol. Chem. 271, 14333-14343. "Characterization of the Denaturation and Renaturation of Human Plasma


Vitronectin. II. Investigation into the Mechanism of Formation of Multimers."

Peterson, C. B., Zhou, B.-B., Hsieh, D., Creager, A. N. H., and Schachman, H. K. (1994) Protein Science 3, 960-966. "Association of the Catalytic Subunit of Aspartate Transcarbamoylase with a Polypeptide Fragment Corresponding to the Zinc Domain of the Regulatory Chain Leads to Increases in Thermal Stability."

Peterson, C. B. (1993) in Biology of Vitronectins and Their Receptors (Preissner, K. T., Rosenblatt, S., Kost, C., Wegerhoff, J., and Mosher, D. F., eds) Exerpta Medica, Vol. 1, pp. 67-74. “Scanning Microcalorimetry and Equilibrium Chemical Denaturation Studies of Human Plasma Vitronectin.”

Zhuang, P., Ming, Y., Holland, J., Peterson, C. B., and Howell, E. E. (1993) J. Biol. Chem. 268, 22672-22679. "Artificial Duplication of the R67 Dihydrofolate Reductase Gene to Create Protein Asymmetry: Effects on Protein Activity and Folding.”

Peterson, C. B., Burman, D. L., and Schachman, H. K. (1992) Biochemistry 31, 8508-8515. "Effects of Replacement of Active Site Residue Gln 231 on Activity and Allosteric Properties of Aspartate Transcarbamoylase.”

Peterson, C. B., and Schachman, H. K. (1992) J Biol. Chem. 267, 2443-2450. "Long Range Effects of Amino Acid Substitutions in the Catalytic Chain of Aspartate Transcarbamoylase. Localized Replacements in the Carboxyl-terminal -Helix Cause Marked Alterations in Allosteric Properties and Intersubunit Interactions."

Peterson, C. B., and Schachman, H. K. (1991) Proc. Natl. Acad. Sci. USA 88, 458-462. "Role of a Carboxyl-terminal Helix in the Assembly, Interchain Interactions and Stability of Aspartate Transcarbamoylase."

Horner, A. H., Kusche, M., Lindahl, U., and Peterson, C. B. (1988) Biochem. J. 251, 141-145. "Determination of the Range in Binding Site Densities of Rat Skin Heparin Chains with High Binding Affinities for Antithrombin."

Peterson, C. B., and Blackburn, M. N. (1988) in Proteins: Structure and Function. Proceedings for the First Symposium of American Protein Chemists. ed., J. J. L'Italien (Plenum Press, New York), pp. 665-672. "Localization and Interaction of Functional Sites on Antithrombin III. Use of an Anti-hapten Antibody as a Structural Probe."

Peterson, C. B., Noyes, C. M., Pecon, J. M., Church, F. C., and Blackburn, M. N. (1987) J. Biol. Chem. 262, 8061-8065. "Identification of a Lysyl Residue in Antithrombin which is Essential for Binding of Heparin."

Peterson, C. B., Morgan, W. T., and Blackburn, M. N. (1987) J. Biol. Chem. 262, 7567-7574. "Histidine-Rich-Glycoprotein Modulation of the Anticoagulant Activity of Heparin. Evidence for a Mechanism Involving Competition with both Antithrombin and Thrombin for Heparin Binding."

Peterson, C. B., and Blackburn, M. N. (1987) J. Biol. Chem. 262, 7552-7558. "Antithrombin Conformation and the Catalytic Role of Heparin. I. Does Cleavage by Thrombin Induce Structural Changes in the Heparin-binding Region of Antithrombin?"

Peterson, C. B., and Blackburn, M. N. (1987) J. Biol. Chem. 262, 7559-7566. "Antithrombin Conformation and the Catalytic Role of Heparin. II. Is the Heparin-induced Conformational Change in Antithrombin Required for Rapid Inactivation of Thrombin?"

Peterson, C. B., and Blackburn, M. N. (1985) J. Biol. Chem. 260, 610-615. "Isolation and Characterization of an Antithrombin III Variant with Reduced Carbohydrate Content and Enhanced Heparin Binding."

Manuscripts Submitted and in Preparation


Minor, K. H., Wilkins-Port, C.E., Kuruganti, S., McKeown-Longo, P., and Peterson, C. B. Biochim. Biophys Acta, submitted on January 14, 2005. “Plasminogen Activator Inhibitor-1 Promotes Localization of Vitronectin to the Extracellular Matrix in Cell Culture. "

Schar, C. R., and Peterson, C. B. (2005). “A Deletion Mutant of Vitronectin Lacking the Somatomedin B Domain Exhibits Residual PAI-1-binding Activity.”

Blouse, G. E., Peterson, C. B., Minor, K. M., Perron, M. J., Saxton, A. M., Anagli, J. Y., and Shore, J. D.. “An Ordered Mechanism for Assembly of Complexes of Vitronectin and Plasminogen Activator Inhibitor-1: Pre-Steady State Kinetic Analysis of Step-wise Binding and Conformational Changes that Trigger Complex Assembly.”

Abstracts of Recent and/or Unpublished Work

Minor, K. H., Schar, C. R., Blouse, G. E., Shore, J. D., Lawrence, D. A., Schuck, P., and Peterson, C. B. (2005) Serpins 2005: The 4th International Sumposium on Serpin Structure, Function and Biology, June 5-9,2005, Cairns, Australia. “ An Ordered Mechanism for Assembly of Complexes of Vitronectin and Plasminogen Activator Inhibitor-1”

Minor, K. H., Schar, C. R., Blouse, G. E., Shore, J. D., Lawrence, D. A., Schuck, P., and Peterson, C. B. (2005) Xth International Workshop on Molecular and Cellular Biology of Plasminogen Activation, April, 2005, Potomac, Maryland. “An Ordered Mechanism for Assembly of Complexes of Vitronectin and Plasminogen Activator Inhibitor-1: Sedimentation Velocity Analysis of Higher-Order Complexes in the Analytical Ultracentrifuge.”

Schar, C. R., Kauffman, S., Horn, N. A., Becker, J. M., and Peterson, C. B. (2004) Annual Retreat of the Tennessee Mouse Genome Consortium, November 17-19, Fall Creek Falls, TN. “A Role for Vitronectin in Fungal Pathogenicity.”

Blouse, G. E., Peterson, C. B., Minor, K. H., Perron, M. J., and Anagli, J. (2004) Gordon Research Conference on Plasminogen Activation and Extracellular Matrix Degradation. “Plasminogen Activator Inhibitor-1 is the Molecular Trigger Eliciting the Slow Assembly of Pro-Adhesive Vitronectin Oligomers.”

Minor, K. H., Peterson, C. B, and Schuck, P. (2004) UK/European Analytical Ultracentrifuge Conference, April 1, 2004, Oxford, England. “Multi-wavelength and Multi-signal Sedimentation Velocity Analysis of Protein Interactions.”

Lynn, B. W., Mayasundar, A., Horn, N., Heller, W., Whittemore, N., Serpersu, E., and Peterson, C. B. (2004) XVIIth International Congress on Fibrinolysis and Proteolysis, March 21-25, 2004, Melbourne, Australia. “A Model of the Structure of Vitronectin from Small-Angle Scattering Measurements and NMR.”

Whittemore, N.A., Mayasundari, A., Horn, N., Serpersu, E. H. and Peterson, C. B. (2004) 227th ACS National Meeting, Anaheim, CA, March 28-April 1, 2004, Anaheim, CA. “Elucidation of the Structure of the Cysteine Knot in the N-terminal Somatomedin B Domain Isolated from Native Vitronectin.”

Blouse, G. E., Minor, K. H., Peterson, C. B., Perron, M. J, and Shore, J.D. (2003) 3rd General Meeting of the International Proteolysis Society, Nagoya, Japan, November 2003. “The Fast Two-Step Binding of Plasminogen Activator Inhibitor-1 Triggers the Slow Assembly of Higher Order Vitronectin Complexes.”


Minor, K. H., Blouse, G. E., and Peterson, C. B. (2003) IX International Workshop on Plasminogen Activation, October 19-23, 2003, Capri, Italy. “A Hydrodynamics Study to Evaluate the Mechanism of Assembly of the PAI-1/ Vitronectin Complex.”

Mayasundari, A., Serpersu, E. S., and Peterson, C. B. (2002) Annual Meeting of American Chemical Society, Orlando, FL. “Structural studies on the N-terminal domain of vitronectin: A disulfide knot.”

Horn, N. A., VerBerkmoes, N., Stephenson, J. L., Jr., Hurst, G. B. and Peterson, C. B. (2002) Gordon Research Conference on Thrombolysis. "Identification of the Disulfides in the Somatomedin B Domain of Vitronectin by Selective Reduction, Proteolysis and Mass Mapping."

Minor, K. H., Wilkins-Port, C., McKeon-Longo, P., and Peterson, C. B. (2002) Gordon Research Conference on Thrombolysis. "PAI-1 and Vitronectin form Complexes that Exhibit Altered Adhesive Properties."

Schar, C. R., Sackman, J. and Peterson, C. B. (1999) the International Congress of Thrombosis and Haemostasis, August 14-17, 1999, Washington, D. C. “Generation and Characterization of Endothelial Cells Transduced with Plasminogen Activator Inhibitor-1 (PAI-1) or Vitronectin.”

Schar, C. R., and Peterson, C. B. (1999), the Second International Symposium on Serpin Structure and Function, June 27-July 1, 1999, Cambridge, UK. “Efforts to increase Adhesion of Transduced Endothelial Cells Using a Retroviral Vector Containing Plasminogen Activator Inhibitor-1 or Vitronectin.”

Johnson, D. A., Peterson, C. B., and Stack, M. S. (1997) NATO ASI Series A: LifeSciences vol. 298, Plenum Press, London (1998). Proceedings of a NATO Advanced Studies Institute held June 20-30, 1997, Rhodes, Greece. "Human Mast Cell Tryptase is Pro-Angiogenic."

Peterson, C. B., Quan, J., and Schachman, H. K. (1991) FASEB Journal 5, A472. "Characterization of Mutant Aspartate Transcarbamoylases (ATCases) with Deletions from the C-terminus of the Catalytic Chain."

Diez-Martin, J., Sikking, R. A., Blackburn, M. N., Peterson, C. B., Fass, D. N., Bowie, E. J. W., and Gilchrist, G. S. (1985) Meeting of the American Society of Hematology. "Acquired Inhibitor of Bovine Thrombin.”

Invited Lectures and Seminars

Invited Speaker, IVth International Conference on Serpin Structure, Function and Biology, Cairns, Australia, June, 2005. “ An Ordered Mechanism for Assembly of Complexes of Vitronectin and Plasminogen Activator Inhibitor-1”

Invited Speaker, Xth International Workshop on Molecular and Cellular Biology of Plasminogen Activation, Potomac, MD, April, 2005. “An Ordered Mechanism for Assembly of Complexes of Vitronectin and Plasminogen Activator Inhibitor-1: Sedimentation Velocity Analysis of Higher-Order Complexes in the Analytical Ultracentrifuge.”

Invited Speaker, XVIIth International Congress on Fibrinolysis and Proteolysis, March 21-25, 2004, Melbourne, Australia. “A Model of the Structure of Vitronectin from Small-Angle Scattering and NMR.”

Pre-Game Showcase, University of Tennessee, UT vs. Kentucky, November 30, 2002. "From Research Lab to the Hospital Room: Contributing to Better Health in Big Orange Country"


Department of Nutrition, University of Tennessee, October 25, 2002. “Being in Two Places at the Same Time: How the Tissue Localization of Vitronectin Influences its Role in Cancer”

East Tennessee State University Medical Center, Department of Internal Medicine, August 27, 2002. “Being in Two Places at the Same Time: How the Tissue Localization of Vitronectin Influences its Role in Cancer.”

American Red Cross, Holland Laboratory, Bethesda, MD, November 14, 2001. "Vitronectin Binding to Physiological Targets Alters Structural and Functional Properties."

Board of Visitors, College of Arts and Sciences, University of Tennessee, November 10, 2001. Invited by Dean Lester to discuss proposed revision to the undergraduate biology curriculum and the HHMI application submitted this October of 2001. "Biology as an Interdisciplinary Science—Ensuring Methodological Training and Quantitative Competency in Life Science Undergraduates.”

American Chemical Society, Division of Natural Science, East Tennessee Chapter, Walters State Community College, Morristown, TN, October 23, 2001. "The Genome, the Proteome, the Physiome—What's Next?"

Board of Trustees, University of Tennessee, October 5, 2001. Invited by Provost Crabtree to discuss proposed revision to the undergraduate biology curriculum and the HHMI application for 10/16/01. “Biology as an Interdisciplinary Science—Ensuring Methodological Training and Quantitative Competency in Life Science Undergraduates.”

Board of Trustees, University of Tennessee, June 22, 2000. Invited by President Gilley to address what it will take for UT to place among the top 25 public research universities. “Biology at the University: Building Connections.”

American Women in Science, Knoxville/Oak Ridge Chapter, June 15, 2000, Oak Ridge, TN. “The Mysteries of Vitronectin: Relations to Cancer Metastasis and Tissue Remodeling.”

Computational Biology Group, Oak Ridge National Laboratory, March 30, 2000, Oak Ridge, TN. “Biochemical and Computational Approaches to the Structure and Function of the Circulatory Protein, Vitronectin.”

University of Tennessee Medical Center at Knoxville, March 28, 2000, Knoxville, TN. “New Insights into the Structure and Function of Vitronectin.”

Gordon Research Conference on Thrombolysis, February, 2000, Ventura CA. “New Insights into the Structure and Function of Vitronectin.”

Department of Biochemistry, University of Missouri, Kansas City, MO, November 11, 1999. “New Insights into the Structure and Function of Vitronectin.”

Hamilton Civic Hospitals Research Centre, Hamilton, Ontario, May 13, 1999. “New Insights into the Structure of Vitronectin-PAI-1 Complexes and Influences on Cell-Binding Function.”

Tuesday Topics seminar, College of Arts and Sciences, University of Tennessee, January 12, 1999. “Clot Busters--Biotechnology Solutions to Old Problems”

1998 Cardiovascular Research Prize Finalist, Council on Circulation, American Heart Association, Scientific Conference on Vascular and Myocardial Aspects of Ischemic Heart Disease, February 23, 1998, Lake Tahoe, CA. “Unexpected Properties of Vitronectin:PAI-1 Complexes and Their Role in Regulating Plasmin Activation.”


Gordon Research Conference on Thrombolysis, February 6, 1998, Ventura, CA. “A Glimpse at the PAI-1-Vitronectin Complex--Unexpected Properties and Implications for Regulating Plasmin Activation and Receptor Interactions.”

Department of Biochemistry and Molecular Biology, Quillen College of Medicine, East Tennessee State University, September 18, 1997. "Evaluation of Heparin Binding to Vitronectin--Insight into the Domain Structure of the Protein"

American Red Cross, Holland Laboratory, Bethesda, MD, June 2, 1997. "Quantitative Analysis of Heparin Binding to Vitronectin--Insight into the Domain Structure of the Protein"

Knoxville Science Club, University of Tennessee, Knoxville, TN, January 31, 1997. "Vitronectin: What Can We Learn From a Plasma Protein?"

Hematology Program Project Seminar Series, Vanderbilt University, Nashville, TN, November 11, 1996. "Vitronectin: An Example of Form Regulating Function."

International Symposium on the Biochemistry and Biology of Serpins, Chapel Hill, NC, April 18, 1996. "The Use of Fluorescent Probes to Characterize Conformational Changes in the Interaction Between Vitronectin and PAI-1." (presentation given by Angelia D. Gibson, a student working on a Ph.D. in the laboratory)

Department of Biochemistry, Louisiana State University Medical Center, Shreveport, LA, October 12, 1995. "Vitronectin: Form, Fold and Function."

Hoechst Celanese Research Day at UTK, Knoxville, TN, February 22, 1995, platform presentation for the Biology Division at UTK. "Vitronectin: Form and Function of a Plasma Protein which Regulates Diverse Physiological Processes."

Department of Macromolecular Research; SmithKline and Beecham Laboratories: King of Prussia, PA, January 6, 1995. "Vitronectin: Form, Fold and Function."

University of Tennessee Hospital, Department of Hematology, Knoxville, TN, February 22, 1994. "Vitronectin: Form, Fold and Function."

Meeting of the “Midwest Clotters,” Toledo, OH, October, 1993

Department of Macromolecular Research; Smith, Kline and Beecham Laboratories; King of Prussia, PA, May, 1991

Center for Advanced Research in Biotechnology, Rockville, MD, May, 1991

Department of Biochemistry, University of Tennessee, Knoxville, TN, February, 1991

Department of Biochemistry and Biophysics, Iowa State University, Ames, IA, February, 1991

Department of Biochemistry, Louisiana State University Medical Center, New Orleans, LA, January, 1991

Department of Biochemistry, West Virginia University Medical Center, Morgantown, WV, December, 1990

Miles-Cutter Pharmaceutical Company, Berkeley, CA, October, 1988

XIth International Congress of Thrombosis and Haemostasis, Brussels, BELGIUM, July, 1987


IXth International Congress of Thrombosis and Haemostasis, San Diego, CA, July, 1985

Other Conference/Workshop Participation

Program Committee, International Society of Fibrinolysis and Proteolysis, June, 2006, San Diego, CA.

Session Chair, Plasminogen Activation Workshop, Washington, DC, April 9-13, 2005

Participant, Workshop on Analytical Ultracentrifugation, University of Connecticut, Storrs, CT, June 25-28, 2002.

Session Chair, Third International Conference on the Chemistry and Biology of Serpins, Session on Serpin-Receptor Interactions, Chicago, IL, June, 2002.

Participant, Short Course on Gene Microarray Development and Analysis: Approaches to Heart, Lung, Blood and Sleep Disorders, Jackson Laboratory, Bar Harbor, ME, April 24 - 28, 2002

Session Chair, Proteomics, Second Annual Retreat of the Tennessee Mouse Genome Consortium, Montgomery Bell State Park, December 5-6, 2001.

Oral Presentation about the Tennessee Mouse Genome Consortium, ORNL Genomics Workshop, Duke University, Durham, NC, April 30, 2001.

Oral Presentation about the Heart, Lung and Blood Application to NIH for the Tennessee Mouse Genome Consortium (TMGC), Annual Retreat of the TMGC, Fall Creek Falls, TN, December, 2000.

Poster Presentation, International Congress of Thrombosis and Haemostasis, August 14-17, 1999, Washington, D. C. “Generation and Characterization of Endothelial Cells Transduced with Plasminogen Activator Inhibitor-1 (PAI-1) or Vitronectin.”

Poster Presentation, ACS regional meeting, October, 1999, Knoxville, TN. “Multivalent Complexes Between Plasminogen Activator Inhibitor-1 (PAI-1) and Vitronectin Show Enhanced Binding to Cell Surface Receptors.”

Organizational Committee, Biological Chemistry Section Leader, ACS regional meeting, October, 1999, Knoxville, TN

Poster Presentation, Second International Symposium on the Biochemistry and Biology of Serpins; Cambridge, UK; June 27-July 1, 1999. “Effects of Binding of Plasminogen Activator Inhibitor-1 to Vitronectin: Formation of Large Multivalent Complexes.”

Poster Presentation, Second International Symposium on the Biochemistry and Biology of Serpins; Cambridge, UK; June 27-July 1, 1999. “Efforts to Increase Adhesion of Transduced Endothelial Cells Using a Retroviral Vector Containing Plasminogen Activator Inhibitor-1 or Vitronectin.”

Invited Participant, Research Symposium highlighting the research of fourth-year Established Investigatorship Awardees, American Heart Association, Dallas, TX, May 1, 1999. “Effects of Binding of Plasminogen Activator Inhibitor-1 to Vitronectin: Formation of Large Multivalent Complexes.”

Invited speaker, Organizational Symposium on the Tennessee Consortium for Mouse Genetics, August 24-25, 1998, Vanderbilt University, Nashville, TN. “Potential Applications for Coagulation/Blood Proteins.”

Invited participant on panel, NIH Workshop on Structural Biology/Functional Genomics, April 24, 1998,


Bethesda, MD. Gave a short presentation on the problems and challenges in protein expression for the Structural Biology initiative

Poster Presentation, Partnering for Functional Genomics Research conference, ORNL/GENRAC, April 16, 1998. “A Glimpse at the Vitronectin:PAI-1 Complex--Unexpected Properties and Their Role in Regulating Plasmin Activation and Receptor Interactions.”

Poster Presentation, Gordon Conference, "Thrombolysis," February 8-13, 1998, Ventura, CA. “A Glimpse at the Vitronectin:PAI-1 Complex--Unexpected Properties and Their Role in Regulating Plasmin Activation and Receptor Interactions.”

Roundtable Discussion Leader, Women in Science and Technology Conference, March 22, 1996, Oak Ridge, TN

Poster Presentation, Gordon Conference, "Fibrinolysis," March 13-18, 1994, Ventura, CA.

Attended a workshop on the computer program, LabView, conducted by National Instruments Corporation, February 14-18, 1994, Knoxville, TN. Served as the departmental representative to the workshop to aid in incorporation of this software in the computer teaching lab.

Poster Presentation, First International Meeting on Vitronectins and Their Receptors, Marburg, Germany, August, 1993.

Accepted upon application for attendance at the Gordon Conference, "Thrombosis and Hemostasis," June, 1991, Vermont.

Ad Hoc Reviewer

Journal of Biological Chemistry Biochemistry Proteins: Structure, Function and Genetics Archives of Biochemistry and Biophysics Biochimica et Biophysica Acta Protein Science

Phytochemistry Blood Infection and Immunity Journal of Proteome Research Journal of Cell Science Journal of Clinical Investigation

Grant Reviews

Research Corporation, Tucson, AZ, January, 1992

National Institutes of Health, Shared Equipment Grants Study Section, June, 1994, Bethesda, MD

Research Corporation, Tucson, AZ, June, 1995

National Institutes of Health, Shared Equipment Grants Study Section, July, 1996, Bethesda, MD

Oak Ridge Associated Universities, Faculty Development Awards, April, 1996 (one review)

National Science Foundation, ad hoc reviewer, Molecular Biochemistry, October, 1996

Susan G. Komen Foundation and The Junior League of Knoxville, February, 1998; served on local review panel for distribution of funds raised by the first Race for the Cure held in Knoxville, TN, in the fall of 1997.

National Science Foundation, ad hoc reviewer, Molecular Biochemistry, April, 1998


National Institutes of Health, Shared Equipment Grants Study Section, August, 1998, Bethesda, MD

Laboratory Director’s Research and Development Funds for Functional Genomics, August, 1998, Oak Ridge National Laboratories, Oak Ridge, TN

National Institutes of Health, Biophysical Chemistry Study Section, Site Visit Review for Program Project Grant, November 15-17, 1998

National Institutes of Health, National Heart, Lung and Blood Institute, Division of Extramural Affairs, Special Review Committee, Program Project Grant, April 21, 1999

National Institutes of Health, National Heart, Lung and Blood Institute, Division of Extramural Affairs, Special Review Committee, Program Project Grant, April 22, 1999

Laboratory Director’s Research and Development Funds for Functional Genomics, August, 1999, Oak Ridge National Laboratories, Oak Ridge, TN

Laboratory Director’s Research and Development Funds for Complex Biological Systems, June-August, 2000, Oak Ridge National Laboratories, Oak Ridge, TN

Laboratory Director’s Research and Development Funds for Functional Genomics, August, 2001, Oak Ridge National Laboratories, Oak Ridge, TN (one review)

New Initiatives Grants, Center of Excellence in Structural Biology, August, 2001, Univ. of Tennessee, Knoxville. (chair of committee)

Panelist, Biochemistry, Biophysics, and Structural Biology Panel, Graduate Research Fellowship Program, National Science Foundation, February 14-16, 2002, Arlington, VA.

National Institutes of Health, National Heart, Lung and Blood Institute, Division of Extramural Affairs, Special Review Committee, Program Project Grant, May 1, 2002

National Institutes of Health, National Heart, Lung and Blood Institute, Division of Extramural Affairs, Special Review Committee, Program Project Grant, January 10, 2003

Panelist, Biochemistry, Biophysics, and Structural Biology Panel, Graduate Research Fellowship Program, National Science Foundation, February 12-16, 2003, Arlington, VA.

Department of Energy, EPSCoR Program, Review and Site Visit, University of Vermont, April 14-16, 2003.

National Institutes of Health, National Heart, Lung and Blood Institute, Division of Extramural Affairs, Special Review Committee, Program Project Grant, September 17, 2003.

National Institutes of Health, Thrombosis and Hemostasis Study Section, Ad Hoc member, October 16-17, 2003.

Louisiana Board of Regents, ad hoc Review of Faculty Research Grant for EPSCoR Program, January, 2004.

National Institutes of Health, National Heart, Lung and Blood Institute, Division of Extramural Affairs, Special Review Committee, Program Project Grant, May 4, 2004.

ORAU Powe Fellowships, ad hoc reviewer, December, 2004


Wellcome Trust, London, UK, ad hoc reviewer, January, 2005

National Science Foundation, Electrochemistry and Surface Chemistry Panel, ad hoc reviewer, March, 2005

Medical Research Council, UK, ad hoc reviewer, April, 2005.

Other Professional Service

Scientific Steering Committee, Tennessee Mouse Genome Consortium, one of two representatives from The University of Tennessee, Knoxville, campus, August, 1998 – present

Outside Reviewer, Biochemistry Program Review, Gustavus Adolphus College, St. Peter, Minnesota, December 2-6, 1998; interim review, November, 2000

Video Production, “A Time for Butterflies,” in conjunction with the UT Center for Telecommunications and Video, March-April, 1999. Worked with producer, Rosemary Walter, to plan and produce an educational video on butterfly development to be distributed to all first grades in Knox County in conjunction with the Second Annual Butterfly Project of the East Tennessee Discovery Center. This project was sponsored by the Division of Biology and the College of Arts and Sciences.

Representative from the University of Tennessee for “Science: Invest in the Future,” a signature event of the Science Coalition, a national organization dedicated to the advancement of Science. Visited Tennessee congressional delegation with the goal of increasing federal funding of university research, September 21-22, 1999, Washington, D. C.

Invited to present on behalf of the Tennessee Mouse Genome Consortium to a group of scientists and administrators from the UT Medical Center in Memphis, 7/17/2000.

Stakeholder/Advisor for the Joint Institute of Biological Sciences, Oak Ridge National Laboratory, Summer, 2001-present

Member of the UT/ORNL Distinguished Scientist Committee, July, 2002 – December, 2004

Postdoctoral Trainees

Ping Zhuang, July 1, 1994 - April 17, 1998.

Baburaj Kunnumal, August 1, 1995 - August, 1997.

Anand Mayasundari, September 1, 1999 – present, Funded through a Postdoctoral Fellowship Award from the American Heart Association, Southeast Regional Affiliate Ref. No. 0120344B, “Structural and Functional Studies on the N-terminal Domain of Vitronectin,” from July 1, 2001 – present; $31,500/yr.

Christine R. Schar, November 1, 2000 – present; Funded through a GST Postdoctoral Fellowship, “Microarray and Proteomics Analysis of Circulating Proteins in Mouse Blood,” from November 1, 2000 – present, $40,000/yr.

Mentor for Graduate Students:


Angelia D. Gibson, Ph.D. student, Biochemistry, June 1, 1994 - May 15, 1998. Dissertation Title: A New Approach to Vitronectin Research: Using Molecular Biology and Biophysical Chemistry to Elucidate the Contributions of the C-terminal Domain of Vitronectin to Heparin BindingAwards: Student Award, American Institute of Chemists Foundation, May 1998

Science Alliance Award for Outstanding Achievement by a Graduate Student, Division of Biology, University of Tennessee, May 1998

Chancellor's Citation for Outstanding Professional Promise, University ofTennessee, April 1998

Wright Fellowship Graduate Student Award for Research, Department ofBiochemistry and Cellular and Molecular Biology, University of Tennessee, January 1998

Travel Award, International Symposium on the Chemistry and Biology ofSERPINS, April 1996, Chapel Hill, NC

Hilton A. Smith Graduate Fellowship, University of Tennessee, 1993-1994Current Position: Assistant Professor, Maryville College, Maryville, TN

Christine R. Schar, Ph.D. student, Biochemistry, June 1, 1995 – March, 2000. Dissertation Title: Expression of Vitronectin and Eukaryotic Cells: Evaluation of PAI-1 Binding and Implications for Gene TherapyAwards: UT Citation of Outstanding Professional Promise, April, 2000

Wright Travel Award for Presentation at the 2nd International Meeting on the Chemistry and Biology of Serpins, Cambridge, UK, June, 1999

Travel Award, The Graduate School, University of Tennessee, for Presentation at the 2nd International Meeting on the Chemistry and Biology of Serpins, Cambridge, UK, June, 1999

Current Position: GST Postdoctoral Fellow, University of Tennessee and Oak Ridge National Laboratory, working on microarray and proteomics analysis of the vitronectin knockout mouse

Kenneth Minor, Ph.D. student, BCMB, June 1, 1997 – presentAwards: Wright Travel Award for Presentation at the 2nd International Meeting on the Chemistry

and Biology of Serpins, Cambridge, UK, June, 1999Travel Award, The Graduate School, University of Tennessee, for Presentation at the

2nd International Meeting on the Chemistry and Biology of Serpins, Cambridge, UK, June, 1999

Wright Research Fellowship for outstanding work as a BCMB graduate student,2002-2003

iWright Travel Award for Presentation at the International Workshop on Plasminogen Activation, Capri, Italy, October, 2003

Invited Speaker, International Analytical Ultracentrifugation Workshop, Oxford, England, April, 2004

Dissertation title: Vitronectin and Plasminogen Activator inhibitor-1 Form higher Order Complexes that Localize to the Extracellular Matrix and Adopt Adhesive PropertiesCurrent Position: Postdoctoral Fellow in the laboratory of Dr. Nicolas Seeds, University of Colorado

Medical Center, Denver, CO

Secil Ozen, M.S. student, BCMB, June 1, 1999 – December, 2001Thesis Title: Structural and Functional Analysis of the Interaction of the Thrombin-Antithrombin Complex with Vitronectin.Current Position: Research Associate, Zymogenetics, Seattle, WA, January, 2002 – present

Jodi Watson, M. S. student, BCMB, June 1, 2001 – November, 2003.Thesis Title: Localizing Ligand Binding Sites Using Overlapping Recombinant Polypeptide Sequences of Vitronectin


Current Position; Research Associate, Emory Medical School

Cindy Brown, Ph.D. student, BCMB, Jun 1, 2003 – presentAwards: CESB Fellowship, 2002-2003, 2003-2004, 2004-2005

Neutron Sciences Fellowship, 2003-2004, $11,000Neutron Sciences Fellowship, 2004-2005, $11,000

Sumit Goswami, Ph.D. student, BCMB, June 1, 2004 - present

Undergraduate Trainees

Susan Ballinger, B. S., Biochemistry, May, 1989, University of California, Berkeley. Supervised Honors Thesis. Thesis Title: “ Intragenic Complementation in E. coli Aspartate Transcarbamoylase.”

Joanne Quan, B. S., Biochemistry, May, 1992, University of California, Berkeley. Supervised Honors Thesis. Thesis Title: “Role of the Carboxyl-terminus in the Assembly and Stability of Aspartate Transcarbamoylase.”

Valerie Blackmon, B.S., Biochemistry, December, 1992, supervised honors work for the CollegeScholars Program, University of Tennessee, Knoxville.

Angelia Douglass Gibson, B.S., Cell Biology, May, 1993, University of Tennessee, Knoxville, supervised undergraduate research for two semesters.

John Todd, B. S., Biochemistry and Math, May, 1994, University of Tennessee, Knoxville, supervised paid employment in the summer of 1992 and then one semester of independent undergraduate research.

Edie D. Riden, B. S., Biochemistry and Chemistry, May, 1994, University of Tennessee, Knoxville, supervised three semesters (Summer and Fall, 1993, and Spring, 1994) of undergraduate research, project involved using PCR to generate mutant fragment of vitronectin.

Cynthia L. Page, B. S., Biochemistry, May, 1994, University of Tennessee, Knoxville, supervised two semesters (Fall, 1993, and Spring, 1994) of undergraduate research; project involved cloning vitronectin into M13 phage for mutagenesis.

Dreeny Chen, Biochemistry Major, Vanderbilt University, Nashville, TN, supervised twosummers paid employment in the laboratory; summer, 1993 and summer, 1994.

Shirnil Channappa, Pre-Medicine Major, The Pennsylvania State University, University Park, PA, supervised one summer undergraduate research; summer, 1993.

Marcus Carpenter, B. S., Biochemistry, May 1994, University of Tennessee, Knoxville,supervised three semesters of undergraduate research (Summer and Fall, 1994, and Spring, 1995); project involved using PCR to generate mutant forms of vitronectin

Walt Chiles, B. S., Cell Biology, May, 1995, University of Tennessee; supervised two semesters of undergraduate research in partial fulfillment of the requirements for the Whittle Scholars program; Fall, 1994 and Spring, 1995. Thesis Title: Use of the BL21 Expression System to Optimize Solubility Conditions of the Vitronectin Protein.

Jason Williams, B. S., Biochemistry, May, 1996, University of Tennessee; mentor for honors thesis and undergraduate research as an Undergraduate Scholar in the Threshold Program funded by the Howard Hughes Medical Institute; academic years 1994-95 and1995-96. Project involved evaluating the sensitivity of vitronectin to reducing agents and the quantification of the number of free and oxidized sulfhydryls in the protein. Thesis Title: Studies of Sulfhydryl Chemistry in Human Vitronectin

Mike Blakeley, B. S., Biochemistry, May, 1997, University of Tennessee; supervised undergraduate research aimed at development and pilot runs on purification of wheat germ acid phosphatase in preparation for Biochemistry 515, the graduate student lab; summer, 1995.

Jennifer Dodd, B. S., Biology, University of Utah, May, 1993; supervised summer research prior to the first semester of graduate school; testing fusions of thioredoxin with the C-terminal domain of vitronectin for solubility; summer, 1995.


Colin Brinkhouse, Biochemistry Major, University of Tennessee, supervised one semester of undergraduate research in the Fall, 1995. Colin chose to quit at that point (during his Sophomore Year) because of lecture course commitments and time constraints

Herbert Li, B. S., Life Sciences, May, 1997, University of Tennessee; supervised in undergraduate research an as Undergraduate Scholar in the Threshold Program funded by the Howard Hughes Medical Institute, Fall, 1995

Janet Effler, B. S., Biochemistry and Chemistry, Spring, 1997, University of Tennessee; supervised for independent research for the summer and fall, 1996 and spring, 1997; work focused on the expression of recombinant fragments of vitronectin in E. coli and detection by Western blotting, enzymatic deglycosylation of vitronectin, and measurement of interactions between vitronectin and collagen

Doug Bradford, B. S., Biochemistry, Spring, 1997, University of Tennessee; supervised for independent research for the summer, 1996 and spring, 1997

Cannon Turner, B.S., Biochemistry, Spring, 1998, University of Tennessee; supervised for independent research for the spring and fall, 1997; work involved optimizing expression of recombinant fragment of vitronectin for localization of ligand interactions

Eric Baurle, B. S., Biochemistry, Spring, 1998, University of Tennessee; supervised for independent research for the summer, 1997; work involved developing immunochemical techniques to monitor vitronectin interactions with collagen.

Billy Standifer, B. S., History, Emory University, B.S., BCMB, expected Spring, 1999; supervised at the point that this student entered for a second degree; Fall, 1997; he worked on protein preparations to gain practical experience with biochemistry

James Mosley, B. S., Life Sciences, Spring, 1999, University of Tennessee; supervised for independent research for the Threshold Program in the Fall semester, 1997 and Spring, 1998; worked on purifying vitronectin

Tiffany Thomas, B. S., Biochemistry, Spring, 1999, University of Tennessee; supervised for independent research for the Threshold Program beginning summer, 1998 and working through the1998-99 academic year on the honors thesis; project involved expressing mutant forms of vitronectin with substitutions in the somatomedin B region using the baculovirus system. Thesis Title: Site-Directed Mutagenesis in the PAI-1 Binding Region of Vitronectin"

Katidja Ali, B. S., Biochemistry, Summer, 1999, University of Tennessee; supervised for independent research for the summer, 1998; worked on molecular biological aspects of expressing vitronectin in cell culture systems

Nancy Creery, B. S., Biochemistry, Fall, 1998, University of Tennessee; supervised for independent undergraduate research for the Fall, 1998; worked on subcloning mutant forms of vitronectin into appropriate baculovirus expression vectors

Christal Secrest, B. S., Biochemistry, Fall, 1999; worked on characterizing a monoclonal antibody raised against vitronectin for effects on function and localization of the recognized epitope

Melissa Alfred, B. S., Biology, Summer, 1999, B. S. Biochemistry, Spring, 2000; supervised in Fall, 1999 for independent research

Laura Terry, B.S., Biology, May, 2003 from William and Mary University; supervised in Summer, 2000 for independent research on mutagenesis and cloning of sulfhydryl mutants in the hemopexin region of vitronectin

Hans Hartwig, B. S. Biology, Fall, 2001, University of Tennessee; supervised for two semesters in Fall, 2000 and Spring, 2001 working on expression of hemopexin-like domains in vitronectin

Jason Susong, B. S., BCMB, May, 2002, University of Tennessee; supervised for one semester of undergraduate research in Spring, 2002, working on cloning of vitronectin into a vector for expression in baby hamster kidney cells

John Fisher, College Scholars Program, B. S., BCMB, May, 2003, University of Tennessee; supervised for several semesters (beginning spring 2002), working on preparing an Fab fragment of a monoclonal antibody for vitronectin for pilot co-crystallization studies

Sheena Edwards, University Honors Student, B. S. Biomedical Engineering, 2004, University of Tennessee, supervised for one semester on a project optimizing solid-phase integrin- binding assays.


Ben Huff, University Honors Student, B.S., BCMB, May, 2004, University of Tennessee; supervised for one semester on a joint project with Dr. Murray Marks in the Department of Anthropology evaluating changes in polyamines within the first two weeks after death.

Michael Maddox, University Honors Student, B.S., BCMB, May, 2004, University of Tennessee; supervised for one semester on a project designed to evaluate changes in gene expression in cancer cells grown on substrata with vitronectin or vitronectin/PAI-1 complexes. This work was pursued in collaboration with Dr. Shannon Eaker of Healthspex, Inc., Knoxville, TN.

Abdelhami Alsharif, B. S., BCMB, May, 2005, University of Tennessee. Supervised in Summer 2004, Fall 2004 and Spring 2005 research working on binding of vitronectin to uPAR.

Ryan Buckley, B. S., BCMB, May, 2005, University of Tennessee. Supervised in Summer 2004, Fall 2004 and Spring 2005 research working on selection of clonal recombinant Chinese Hamster ovary cell lines transfected with vitronectin.

Kevin Walters, University Honors Student, B.S. BCMB, expected in 2006, University of Tennessee. Supervised in Spring 2005 research evaluating specific sites on vitronectin that are involved in its self-association into an adhesion protein.

Kit Nazor, B.S. BCMB, May, 2005, University of Tennessee. Supervised in Spring 2005 research evaluating conversion of vitronectin from a monomeric circulatory protein to a multimeric adhesive form, testing the binding of cultured cells to the different forms associated with a commercial extracellular matrix.

Lesley Wallace, B.S. Biology, expected May 2007 from Vanderbilt University. Supervised for Summer 2005 research on the binding and effects on function that arise from a series of monoclonal antibodies for vitronectin.

Teaching Assignments and Professional Development

Participated as a Faculty Mentor in the GTA Mentoring Program at UTK in the 2000-2001 academic year and again in the 2001-2002 academic year. This program is sponsored by the Graduate School and is led by Jan Allen. Faculty mentors lead small group discussion regarding the challenges and opportunities offered by a career in academics.

Featured faculty in “ITC Spotlight” for April, 2003 for creative use of information technology in teaching. This web site summarized new initiatives taken in teaching as a result of the 2002 “Faculty First” award.

External Reviewer for three chapters in the 6th Edition of Biochemistry by Berg and Stryer, January, 2005

BCMB 401 “Biochemistry”Spring, 2004Fall, 2004Spring, 2005

BCMB 420 ”Advanced Topics in Biochemistry”Spring, 1992Spring, 1993Spring, 1998Spring, 2005 (1 guest lecture on Angiogenesis)

BCMB 452 “Independent Research in Biochemistry”Fall, 1992 (Valerie Blackmon and Angelia Douglass) Spring, 1993 (John Todd)Summer, 1993 (Edie Riden)Fall, 1993 (Edie Riden and Cynthia Page)Spring, 1994 (Edie Riden and Cynthia Page)Summer, 1994 (Marcus Carpenter)


Fall, 1994 (Marcus Carpenter)Spring, 1995 (Marcus Carpenter, Walt Chiles, and Jason Williams)Summer, 1995 (Mike Blakeley)Fall, 1995 (Jason Williams and Herbert Li)Spring, 1996 (Jason Williams)Summer, 1996 (Janet Effler and Doug Bradford)Fall, 1996 (Janet Effler)Spring, 1997 (Janet Effler and Cannon Turner)Summer, 1997 (Eric Baurle)Summer, 1998 (Katidja Ali)Fall, 1998 (Tiffany Thomas and Nancy Creery)Fall, 1999 (Melissa Alfred and Christal Secrest)Fall, 2000 (Hans Hartwig)Spring, 2001 (Hans Hartwig)Spring, 2002 (Jason Susong and John Fisher)Fall, 2002 (John Fisher and Bessie Yang)Spring, 2003 (Bessie Yang)Fall, 2003 (Sheena Edwards)Spring, 2004 (Michael Maddox, Benjamin Huff)Fall, 2004 (Abdelhamid Alsharif, Ryan Buckley)Spring, 2005 (Abdelhamid Alsharif, Ryan Buckley, Kevin Walters, Kit Nazor)

Biochemistry 462, "Senior Seminar"1 lecture, Spring, 19941 lecture, Spring, 1995

Biology 303, "Research Colloquium for the HHMI Threshold Program"1 lecture, Spring, 1996. This presentation was intended to introduce Juniors in the Threshold Program

to the types of research that are being pursued in my laboratory.1 lecture, Spring, 1997. This was the same sort of presentation to the new Junior class in the

Threshold Program.

Biology 395, “Threshold Honors Laboratory Research Rotation”Spring, 1996Spring, 1997Spring, 1998Spring, 2004

BCMB 513 “Advanced Cell Biology”2 lectures, Spring, 19982 lectures, Spring, 19992 lectures, Spring, 20016 lectures, Spring, 20026 lectures, Spring, 2003; Course Coordinator6 lectures, Spring, 20046 lectures, Spring, 2005

BCMB 515 “Experimental Techniques I”Fall, 1993Fall, 1994Fall, 1995Fall, 1996Fall, 1997Fall, 1998


Fall, 2000Fall, 2001Fall, 2002

BCMB 516 “Experimental Techniques II”Spring, 1992 (Alan Smith)Spring, 1993 (Tony Chen and Sudha Subramanian)Spring, 1994 (Angelia D. Gibson and Toyu Huang)Spring, 1995 (Christine Schar, Tonia Lane, and Huo Li)Spring, 1996 (Mark Geller and Jennifer Dodd)Spring, 1997 (Kenneth Minor)Spring, 1998 (Vanny Narita and Shannon Eaker)Spring, 1999 (Secil Ozen)Spring, 2000 (Ed Wright)Spring, 2001 (Jodi Watson and Lezlee Turner)Spring, 2002 (Srilalitha Kuruganti, Shelley Crispin, and Shaileja ChopraSpring, 2003 (Louisa Villeneuve, Cindy Brown, Evan Reddick)Spring, 2004 (Sumit Goswami, Guy Wiles, Jae Hoon Bahn)Fall, 2004 (name of student here)

LS505, GST Rotation StudentsFall, 2000 (Matt Sega)Spring, 2001 (Christal Secrest)Fall, 2001 (Trupti Joshi)Fall, 2004 (Anirban Mukherjee)

BCMB 525 “Graduate Research Participation”Participated continuously since Fall, 1992

BCMB 560, “Advanced Concepts in Structural Biology/Biochemistry”Spring, 1999; Spring 2001: Fall 2003 (co-taught with Liz Howell)

BCMB 560/LS530, “GST IV”Spring, 2003. Taught sections on spectroscopy and hydrodynamics (6 lectures).Spring, 2004. Taught sections on spectroscopy and hydrodynamics (6 lectures).Spring, 2005. Taught sections on spectroscopy and hydrodynamics (6 lectures).

Biochemistry 603, “Current Topics in Biochemistry” seminarPresented departmental seminar in Spring, 1993 entitled, “Structure/Function Relationships in the Human Plasma Glycoprotein, Vitronectin”

BCMB 601, "Advanced Biochemistry Seminar"Presented departmental seminar in Fall, 1995, entitled, "Vitronectin: Form and Function of a Self-Associating Protein"

Biochemistry 621, "Advanced Topics in Protein Folding and Association" Co-organizer of this course held in Spring, 1995, with Liz Howell. This course was a special topics

course for which leaders in the field of protein folding from all over the U.S. were invited to give a research seminar and spend an additional class period with the students enrolled. Speakers for the course were: Pat Jennings, University of California, San Diego; Brian Matthews, University of Oregon; Jonathan King, M.I.T., Charles Brooks, III, Carnegie Mellon University; Janette Carey, Princeton University; Ken Ingham, Red Cross Laboratory, Bethesda, MD; Phil Bryan, CARB; Tom Alber, University of California, Berkeley; Carl Frieden, Washington University; Tony Gatenby, Dupont; and Jiri Safar, NIH. Funds for the course came from the department and from the Biology Division at ORNL.


BCMB 606, Journal Club, Structural Biology, Spring, 1998

UH-348, University Honors Seminar, Spring, 2003. “Life in the Post-Genome Era: Impacts on Modern Science and Medicine”

Departmental Service

Executive Committee January, 1998 – July, 2004

Chair, Search Committee, (Junior position in Structural Biology) April, 1998-June, 1999

Undergraduate Advising, average of 12 students/year continually from 1995 to present

Graduate Student Recruiting Committee 1992-931993-941994-95

Graduate Affairs Committee, 1995-96 (Chair)1996-97 (Chair)1997-98 (Chair)1998-991999-20002001-2002 (Chair)2002-2003 (Chair)2003-2004 (Chair)

Workload Committee 1993-941994-951995-961996-971997-981998-99 (Chair)1999-2000 (Chair)2001-20022002-20032003-2004 2004-2005 (Chair)

Wright Fellowship Committee 1997-982003-2004

Ad Hoc Committee to Set Up Computer Lab 1992-93

Computer Committee 1994-951995-96

Curriculum Committee 1994-952004-2005

Search Committee, Instructor for 1995-96Biochemistry 310 and Biochemistry 419


Peer Review of TeachingLiz Howell Fall, 1993Sundar Venkatachalam Spring, 2005

Division of Biol. Human Subjects Committee 1996-97

Search Committee September, 2002 – December, 2003(Two Assistant Professors in Cell Biology)

Social/Awards Committee 2003-2004

Member on Student Committees:Janel Holland, M. S., Biochemistry, degree awarded Summer, 1993Mathew Greenberg, M. S., Microbiology, degree awarded Fall, 1994John Lamerdin, Ph.D., Biochemistry, degree awarded Summer, 1997Enrico DiGiammarino, M. S., Biochemistry, Spring, 1995, degree awarded Fall, 1995; Ph.D.

Biochemistry; degree awarded Fall, 1997Chang-Hoon Han, Ph.D., Biochemistry, degree awarded Summer, 1996Holly Pinkart, Ph.D., Microbiology, degree awarded Fall, 1996Yaa Difie Osei, Ph.D., Biochemistry, degree awarded Fall, 1995Kamesh Pappu, Ph.D., Biochemistry, degree awarded Fall, 1996HeonYong Park, Ph.D., Biochemistry, degree awarded Fall, 1996Steve Kubala, M.S., Physics, degree awarded Spring, 1996Stacy Gerke, M.S., Physics, degree awarded Spring, 1996Angelia D. Gibson, Ph.D., Biochemistry, degree awarded Spring, 1998Christine Schar, Ph.D., Biochemistry, degree awarded Fall, 1999Jeff Wiles, M.S., Microbiology, awarded Fall, 1999Tonia Lane, M.S., Biochemistry, degree awarded Summer, 1997Brad Strader, M. S., Biochemistry, awarded Fall, 1997; Ph.D., BCMB, degree awarded Fall, 2002Keith Henry, Ph.D., Cell, Molecular and Developmental BiologyMike Stebbins, Ph.D., Chemistry, degree awarded Summer, 1997Cynthia Brimer, M.S., Microbiology, degree awarded Summer, 1997Fred West, M.S., Biotechnology, degree awarded Fall, 1997Ken Price, Ph.D., Chemistry, degree awarded Summer, 1997Jennifer Dodd, Ph.D., BCMB, awarded Spring, 2000Michael Mohler, M.S., BCMB, degree awarded Spring, 1997Li Weikei, M.S., BCMB, degree awarded Summer, 1997John Wilgus, M.S., Biotechnology, degree awarded Fall, 1996Brad Hamilton, M. S., Biotechnology, degree awarded Fall, 1997Claire Hamilton, M. S., Biotechnology, degree awarded Summer, 1998Kenneth W. Minor, M. S., BCMB, degree awarded Summer, 2004Greg Delozier, M. S., Biotechnology, degree awarded Summer, 1998Shannon Eaker, Ph.D., BCMB, degree awarded Fall, 2001Vanny Narita, M.S., BCMB, degree awarded Spring, 2002Ayca Akal-Strader, Ph.D., BCMB, degree awarded Summer, 2004Paula Cameron, M. S., Engineering, degree awarded Spring, 1999Secil Ozen, M.S., BCMB, degree awarded Fall, 2001Drew Eckman, M.S., BCMB, degree awarded Summer, 2000Bin Jiang, Ph.D., Chemistry, degree awarded Fall, 1999Stephanie Hicks, Ph.D., BCMB, degree awarded Fall, 2003Amy Inselman, Ph.D., BCMB, degree awarded Summer, 2003Ed Wright, Ph. D., BCMBLori Stinnett, Ph.D., BCMB, degree awarded Spring, 2004Jodi Watson, MS, BCMB, degree awarded Fall, 2003


Jim Shaeper, PhD, Chemistry, degree awarded Summer, 2002Justin Holland, MS. Engineering, degree awarded Summer, 2004Heather Connelly, Ph.D., GST ProgramQin Xu, Ph.D., BCMBCindy Brown, PhD, BCMBEvan Reddick, PhD., BCMBDemet Ataman, PhD, GST ProgramEric Vincill, PhD, BCMBSumit Goswami, PhD, BCMB

Member on Student Preliminary Examination Committees:Kamesh Pappu, Fall, 1993Heonyong Park, Fall, 1993Mark Lubkowitz, Fall, 1994, MicrobiologyJungWeon Lee, Spring, 1995Enrico DiGiammarino, Fall, 1995; repeat exam, Spring, 1996Keith Henry, Fall, 1996Jennifer Dodd, Fall, 1997, ChairBrad Strader, Fall, 1998; repeat exam, Spring, 1999Ayca Akal-Strader, Spring, 1999; repeat exam, Fall, 1999Vanny Narita, Fall, 1999, Chair; repeat exam, Fall, 2000Shannon Eaker, Spring, 2000Stephanie Hicks, Fall, 2000Amy Inselman, Spring, 2001Lori Stinnett, Fall, 2001Ed Wright, Spring, 2002, ChairShannon Matulis, Fall, 2002Srilalitha Kuruganti, Fall, 2003; repeat exam, Fall, 2004Evan Reddick, Fall, 2004, ChairQin Xu, Fall, 2004; repeat exam, Spring, 2005

Service to the GST Program

GST Steering Committee, 1998- presentGST Recruiting Committee, Co-Chair, 1999-2001GST Curriculum Committee, Chair, 2003 - presentGST Comprehensive Exam Committee Chair, 2003, 2004

Other Institutional Service

Departmental Representative, International Ambassadors Program, March, 1993. This program is designed to prepare current UT international students from underrepresented countries to return to their home countries with recruiting information about the University of Tennessee.

Departmental Representative, Meeting of Residents in Hess Hall, March, 1993. The program for this evening, entitled "Women in the 90's," included a panel of three women who discussed family and career issues.

Mentor, The University of Tennessee Math and Science Regional Center, Summer 1993

Mentor, NIH High School Minority Research Apprentice Program, Summer 1993

Departmental Representative, Meeting of the Naturalist Club, “How to Choose the Right Biology Major," Spring, 1993; Fall, 1993


Departmental Representative, “Biology 2000” committee, Fall, 1993. This committee evaluated the current status and future needs of the Division of Biology in terms of strengthening our current emphases and targeting new research areas.

Featured with student, Angelia D. Gibson, in a 1994 public relations brochure prepared by the Office of Research Administration entitled, “Teaching and Research: Partners in Learning.” This publication emphasizes the positive influence that faculty research has on teaching at the undergraduate level.

Invited luncheon speaker for an event organized by female graduate students in the Biology Division entitled, "Bring Your Daughter to Work," April 28, 1994. This program brought middle school girls from disadvantaged backgrounds in an inner city school to U.T. to spend a day with a female graduate student mentor.

Internal reviewer for the Academic Program review of the Department of Physics, September 26-28, 1994.

Departmental Representative, steering committee for the Threshold Program in the Biological Sciences granted by the Howard Hughes Institute to implement the program beginning Fall, 1995.

Science Alliance Faculty Award Review Committee, Spring, 1995; Spring, 1999; Spring, 2000

Panel Member for briefing of the Advisory Board for the College of Arts and Sciences; May 5, 1994; discussion addressed the interplay between research and teaching and emphasized the Hughes Threshold Program

Undergraduate Advising, 1995 – present (average of 12 advisees per semester)

Speaker to NIH Summer Program for Minority High School Students, July 21, 1995; discussed research interests with vitronectin and some personal aspects of research training and career choices

One of a panel of departmental representatives who gave short introductions of research interests to Dr. Michael Devine, Vice-Chancellor for Research, Spring, 1996

Mentor, NIH High School Minority Research Apprentice Program, Summer 1996

Judge, Natural Sciences Category, Undergraduate Research Fair, University of Tennessee, Knoxville, April 2, 1997

Internal reviewer for the Mid-Cycle Program review of the Department of Physics, September 22-23, 1997.

Faculty Search Committee, Department of Microbiology, work begun Fall, 1997. Position filled Spring, 1998 for AY 1998-99.

Steering Committee for the Program in Genome Science and Technology, a committee to Re-engineer the Biomedical Graduate School at ORNL, December 1997-present

Alumni Academic Hall of Fame Board of Governors, 1998-99; 1999-2000; 2000-2001

Judge, Graduate Student Division, Poster Session, University of Tennessee Medical Center Research Day, May 21, 1998

Faculty Development Awards Research Review Panel; University of Tennessee; Fall, 1998


Review Committee for John Muldowny, by appointment of the Chancellor's Faculty Senate Standing Committee to Oversee Administrative Evaluation, Spring, 1999.

Chair of Internal Review Committee for the Academic Program review of the Department of Anthropology, October, 1999. mid-cycle review September, 2003.

Panelist for the College of Arts and Sciences at the Scholars Invitational Recruiting Day on November 20, 1999. Spoke to the students and parents about the Threshold Honors Program and about the opportunities for undergraduate research at UT.

Lecturer, Kids University, Summer 2000. Participated in a course of “Women Role Model” that discussed various career options; presented to girls ages 6th through 9th grade

Faculty Mentor, GTA Mentoring Program, Academic Year 2000-2001, Academic Year 2001-2002.

Faculty Search Committee, Nutrition Department, work begun Fall, 2000. Two position filled Summer, 2001 for AY 2001-2002.

Faculty Search Committee, Head, Department of Biochemistry and Cellular and Molecular Biology, Spring 2001, position filled same semester.

Executive Committee and Associate Director, Center of Excellence in Structural Biology, January, 2001-present

UTK Committee for University Knoxville, July, 2001 - present.

Chair, University of Tennessee Radiation Safety Committee, August, 2001 – March, 2001.

Search Committee, Radiation Safety Officer for the University of Tennessee, search commenced August of 2001 and completed in 2002.

Featured Faculty for Classroom Visitation, Development Council for the University of Tennessee, September 27, 2001

Search Committee, Honors Program, University of Tennessee, Knoxville, work begun March, 2002 and completed May, 2003.

Invited Lecturer in course entitled, “Women in Science,” coordinated by Dr. Charmaine Mamantov in the Department of Chemistry. Met with the class on April 8, 2002.

Leadership Institute, University of Tennessee, Gatlinburg, TN, February 17-21, 2003.

Post-Tenure Review Committee, Review of Associate Professor Murray Marks, Department of Anthropology, March, 2004.

Scholarship Review Committee, College of Arts and Sciences, March, 2004 – present

Reviewer, Yates Dissertation Fellowship, Graduate School, University of Tennessee, Spring, 2004.

Joint UT/ORNL Advisory Committee for construction of the JIBS facility, Spring, 2004.

Search Committee, Dean, College of Arts and Sciences, work begun June, 2004 and completed in February of 2005.


University Honors Program Curriculum Committee, Spring, 2004 – present.

Internal Reviewer for University of Tennessee applicants for Oak Ridge Associated Universites (ORAU) Powe grants, December, 2004.

Internal reviewer for Cunningham Teaching Award, College of Arts & Sciences, Univ. of Tennessee, May, 2005.

Community Involvement

Junior League of Knoxville, 15 years of service as an Active Member (1984-1999) of the Junior League in three different cities; Sustaining Member, 1999-presentVolunteer of the Month Award, March, 1990, San FranciscoAsst. Chair of Community Research and Project Development; 1995-96, KnoxvilleChair of Community Research and Project Development; 1996-97, KnoxvilleVolunteer of the Month Award; April, 1996, KnoxvilleBoard of Directors, 1996-97, KnoxvilleKnoxville Connects Advisory Board, 1996-97, KnoxvilleFuture Planning Committee, 1996-97, KnoxvilleOutstanding Service Award, 1996-97, KnoxvilleMembership Advisor, 1997-98, KnoxvilleBoard of Directors, 1998-99, KnoxvilleRecording Secretary, 1998-99, KnoxvilleBoard of Directors, 1999-2000, KnoxvilleBoard of Directors, 2000-2001, Knoxville

Volunteer for monthly science demonstrations, Sequoyah Elementary, First Grade Classroom, 1995-96; Second Grade Classroom, 1996-97

Board of Trustees, East Tennessee Discovery Center, November, 1995 - presentExecutive Committee of the Board, February, 1997 – presentChair, Program Committee for Smithsonian Task Force, March, 2000 - present

Board of Directors, Presbyterian Student Center, November, 1998 – October, 2001

First Presbyterian Church of KnoxvilleVisitation and Evangelism Committee, 1997 - December, 1998Christian Education Committee, May, 1998 – December, 2000Officer Nominating Committee, Summer, 1998Laura Pettway Lecture Series Committee, 1996-97, 2000-2003Long-Range Plan Implementation Committee, Spring, 1999-December, 2000Search Committee, Director of Christian Education, Summer, 1999-Spring, 2000Board of Deacons, January, 2000-December 2002Chair, Communications Committee, January, 2000 – December, 2001Church School Teacher, Kindergarten, 2000 – presentFinance Committee, January, 2004 - present

Board of Directors, Region 279 of the American Youth Soccer Organization (AYSO), Child Protection Advocate, Spring, 1999-2000 Certified Spring, 1999Nominating Committee, Fall, 1999 – 2000

Board of Directors, University Club, January 2002 - December 2004.


Board of Directors, University Club Swim Team, September, 2004 – August, 2007

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