cv dr. lawrence j. delucas - space island group · dr. lawrence j. delucas curriculum vitae name:...

Curriculum Vitae

Dr. Lawrence J . DeLucas

CURRICULUM VITAE

NAME: Lawrence J. DeLucas

BIRTHDATE: July 11, 1950

PLACE OF BIRTH: Syracuse, New York

MARITAL STATUS: Married: wife, Kathy

CHILDREN: Rob, Katie and John

NATIONALITY: U.S.A. Citizen

TITLE: Professor, Department of Optometry

Director, Center for Biophysical Sciences and Engineering

Director, Comprehensive Cancer Center X-ray Core

Facility

Senior Scientist, Comprehensive Cancer Center

Curriculum Vitae


EDUCATION:

1972 University of Alabama at Birmingham, Birmingham, Alabama (B.S., Chemistry)

1974 University of Alabama at Birmingham, Birmingham, Alabama (M.S., Chemistry)

1979 University of Alabama at Birmingham, Birmingham, Alabama (B.S., Physiological Optics)

1981 University of Alabama at Birmingham, School of Optometry, Birmingham, Alabama (O.D.)

1982 University of Alabama at Birmingham, Department of Biochemistry, Birmingham, Alabama (Ph. D.)

HONORS: National Optometry Hall of Fame (October 2002)

Honorary Doctor of Science Degree, Ferris State University, Big Rapids, MI (May 2002)

Distinguished Faculty Lecturer, University of Alabama at Birmingham (October 2000)

Humanitarian Award for Outreach Activities, Lions Club (March, 2000)

Honorary Doctor of Science Degree, Ohio State University (June, 1999)

Recipient of the Howell Heflin Statesmanship Award for Technology (April, 1999)

Curriculum Vitae


Honors Recognized as one of the scientists who could shape the 21st century in an article published by “The Sunday Times” of London titled “The Brains Behind the 21st Century” (January, 1999)

Honorary Doctor of Science Degree, Illinois College of Optometry (May, 1998)

Order of Rio Branco award, rank of Commander from the Brazilian Government on behalf of the President of Brazil and the Grand Master of the Order of Rio Branco (1998) (Order of Rio Branco is awarded to recognize and celebrate the merits of Brazilian and foreign individuals who have significantly contributed to the promotion of Brazil’s relations with the world.)

NASA Public Service Medal for exemplary performance in support of the Microgravity Projects Office (June, 1997)

Medal from Instituto Nacional de Pesquisas Espaciais (Brazilian Space Agency) in recognition of joint collaboration on STS-83 and STS-84 (May, 1997)

Honorary Doctor of Science Degree, State University of New York State College of Optometry (May, 1997)

Key to the City of Titusville, Florida for contributions to America’s Space Program (April, 1997)

Curriculum Vitae


Honors Chief Scientist for International Space Station at NASA Headquarters (October 1994 - October 1995)

“Spirit of Columbus” Award, Birmingham, Alabama (October, 1993)

Distinguished Crystallography Lecturer for Pittsburgh Diffraction Society Lectures, Pittsburgh, Pennsylvania (October, 1993)

Keynote Speaker, American Institute of Physics Corporate Associates Meeting, Buffalo, New York (October, 1993)

Speaker, Peter B. Sherry Memorial Lecture, Atlanta, Georgia (April, 1993)

Speaker, F. L. “Bud” Suddath Memorial Symposium, Atlanta, Georgia (April, 1993)

National Aeronautics and Space Administration Group Achievement Award for “Microgravity Experiments Design, Development and Operations Team” (February, 1993)

National Aeronautics and Space Administration Space Flight Medal (July, 1992)

Payload Specialist for United States Microgravity Laboratory-1, (Space Shuttle launch date: June 25,

Curriculum Vitae


1992); established new record for longest duration space shuttle flight.

“Honorary Walk Chairman” by the Juvenile Diabetes Association (October, 1992)

"Optometrist of the Year" by the Southeastern Optometric Association (February, 1992)

First Annual UAB "Distinguished Alumnus Award" (December, 1991)

NASA Research Award for research hardware patent entitled "Protein Crystal Growth Vapor Diffusion Apparatus for Microgravity " (September, 1988)

1st Place in Graduate Student Research Competition sponsored by Sigma Xi (June, 1975)

ADMINISTRATIVE APPOINTMENTS:

1994-present Director, Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham

1994-present Director, Comprehensive Cancer Center X-ray Core Facility, University of Alabama at Birmingham

1992-1994 Deputy Director, Center for Macromolecular Crystallography, University of Alabama at Birmingham

Curriculum Vitae


1985-1992 Associate Director, Center for Macromolecular Crystallography, University of Alabama at Birmingham

1985-1988 Director, Purification and Crystallization Laboratory in the Center for Macromolecular Crystallography, University of Alabama at Birmingham

ACADEMIC APPOINTMENTS:

2002-present Assistant Professor, School of Biomedical Engineering, University of Alabama at Birmingham

2002-present Sparkman Center Scholar, School of Public Health,

University of Alabama at Birmingham 2001-present Adjunct Professor, Physiology and Biophysics,

University of Alabama at Birmingham 1997-present Member, Government Relations Group, University of

Alabama at Birmingham

1996-present Member, Center for Metabolic Bone Disease, University of Alabama at Birmingham

1990-present Adjunct Professor, Department of Biochemistry, University of Alabama at Birmingham

1990-present Adjunct Professor, Laboratory of Medical Genetics, University of Alabama at Birmingham

1989-present Professor, Department of Optometry, University of Alabama at Birmingham

Curriculum Vitae


1989-present Adjunct Professor, Materials Science, University of Alabama

1989-present Adjunct Professor, Materials Science, University of Alabama at Birmingham

1989-present Adjunct Professor, Materials Science, University of Alabama in Huntsville

1984-present Senior Scientist, Comprehensive Cancer Center, University of Alabama at Birmingham

1983-present Member, Graduate Faculty, University of Alabama at Birmingham

1982-present Senior Scientist, Research Center in Oral Biology, University of Alabama at Birmingham

1982-present Senior Scientist, Vision Science Research Center Faculty, University of Alabama at Birmingham

1997-1998 Member, Research Foundation and Technology Transfer Committee, University of Alabama at Birmingham

1996-1998 Member, Structural Biology Working Group, University of Alabama at Birmingham

1985-1989 Associate Professor, Department of Optometry, University of Alabama at Birmingham

Curriculum Vitae


1982-1985 Assistant Professor, Department of Optometry, University of Alabama at Birmingham School of Optometry

1982-1985 Member, Vision Science Research Center Faculty, University of Alabama at Birmingham School of Optometry

1976-1982 Graduate Student Assistant, Institute of Dental Research, working on a Ph.D. in the Department of Biochemistry (research project - X-ray diffraction study of the protein, transferrin), University of Alabama at Birmingham

1975-1976 Research Associate in the Crystallography Laboratory of Dr. Charles E. Bugg in the Institute of Dental Research, University of Alabama at Birmingham

1973-1975 Graduate Student Assistant, Institute of Dental Research, University of Alabama in Birmingham, working on a Masters degree in Chemistry (completed May, 1975), under the supervision of Dr. C. E. Bugg. Also worked as a Lab Instructor, Inorganic and Organic Chemistry, University College

BOARD MEMBERSHIPS:

2003-present Member, Board of Governors, Indian Springs School 2003-present Member, Board of Directors, Birmingham Area

Technology Leadership Alliance 2003-present Member, Scientific Advisory Board, Fluidigm

Corporation

Curriculum Vitae


1999-2000 President, Board of Directors, Alabama State Biotechnology Association

1999-2000 Member Alabama Information Technology Association

(AITA) Board of Directors

1999-present Member, Scientific Advisory Board, National Space Development Agency of Japan

1998-present Member, Board of Trustees, Illinois College of Optometry

1997-present Chair, Science Advisory Board, Diversified Scientific, Inc.

1995-2002 Co-Chairman, SPACEHAB Science Advisory Board

1995-present Challenger Learning Center Advisory Board

1995-2002 Secretary, National Council of Biotechnology Centers, Biotechnology Industry Organization

1997-1999 Alumni Board of Directors, School of Optometry, University of Alabama at Birmingham

1997-1999 Vice President, Board of Directors, Alabama State Biotechnology Association

1987-1992 Vision Science Research Center Advisory Board, University of Alabama at Birmingham

1986-1988 Alumni Board of Directors, School of Optometry, University of Alabama at Birmingham

Curriculum Vitae


COMMITTEES:

2004-present External Advisory Committee, Research Infrastructure in Minority Institutions (RIMI), Alabama State University

2001-present Review committee, Crystal Growth and Design Journal

1998-present Steering Committee, Center for International Research, University of Alabama at Birmingham

1998-2001 Search Committee for Chairman of Biochemistry and Molecular Genetics, University of Alabama at Birmingham

1998-1999 Chairman of Search Committee for Vice President of Development, Helen Keller Eye Research Foundation

1997-present Research Foundation and Technology Transfer Committee, University of Alabama at Birmingham

1996- 2003 Space Station Science Utilization and Advisory Subcommittee, NASA Headquarters, Washington, DC

1996-present Structural Biology Working Group, University of Alabama at Birmingham

1996-present U.S. Space and Rocket Center Advisory Committee, Huntsville, Alabama

Curriculum Vitae


1996-present Member, American Institute of Aeronautics and Astronautics (AIAA) Space Processing Technical Committee, AIAA Headquarters, Reston, Virginia

1990-present Member, Executive Committee, Helen Keller Eye Research Foundation

1987-present Member, Materials Science Program Committee, University of Alabama at Birmingham

1997-1999 Engineering Foundation Council, University of Alabama at Birmingham

1996-1999 Member, Advisory Committee on the International Space Station, NASA Headquarters, Washington, DC

1990-1996 Comprehensive Cancer Center Internal Review Committee, University of Alabama at Birmingham (1990-1996)

1989-1990 Search Committee for Chairman of Materials Science Department, University of Alabama at Birmingham

PROFESSIONAL ORGANIZATIONS:

1. American Crystallographic Association

2. American Academy of Optometry

3. American Institute of Aeronautics and Astronautics

4. American Association of Pharmaceutical Scientists

5. National Aeronautic Association

Curriculum Vitae


6. Biotechnology Industry Organization (BIO)

7. Biotechnology Association of Alabama

8. American Chemical Society

9. Alabama Optometric Association

INTELLECTUAL PROPERTY (Patents: filed, pending, or issued):

1. “Crystals of Factor D”, DeLucas, L. J. and Volanakis, J.E.

2. "Method to Prepare Crystals of Factor D", DeLucas and Volanakis.

3. “Macromolecular Crystal Growing System”, Snyder, Herren, Carter, Yost, DeLucas, Suddath, Bugg,

4. “Device to Monitor and Control Macromolecular Crystal Growth in Microgravity”, Bugg, DeLucas, Rosenblum, Wilson, Chapman, Kennedy.

5. “Crystallizing Biological Macromolecules in Microgravity”, Trotta, Nagabhushan, Bugg and DeLucas.

6. “Crystallizing Biological Macromolecules in Microgravity”, Trotta, Nagabhushan, Bugg and DeLucas.

7. “Temperature Gradient Device for Investigation of Protein Solution Temperature Dependence”, Bishop, DeLucas, and Kim.

8. “New Crystallization Systems Envisioned for Microgravity Studies”, Bray, Kim, Harrington and DeLucas.

9. "Method and Apparatus for Crystallizing Macromolecules in Microgravity", Bugg, DeLucas, Nagabhushan, Trotta, Harrington, and Bishop.

Curriculum Vitae


5. “High Density Protein Crystal Growth”, Delucas, Rouleau, Hedden, Banaseiwicz.

6. “Dynamically Controlled Protein Crystal Growth”, Bray, Kim, Harrington, Delucas.

7. “Method for Acquiring, Storing and Analyzing Crystal Images”, Gester, Rosenblum, Christopher, Hamrick, Tillotson, DeLucas.

8. “Method for Distinguishing Between Biomolecule and Non-Biomolecule Crystals” Delucas, Bray.

9. Use of Dye to Distinguish Salt and Protein Crystals under Microcrystallization Conditions” Cosenza, Bray, Gester, DeLucas, Hamrick.

10. “Method for Screening Crystallization Conditions in Solution Crystal growth”, DeLucas.

11. “Method for Preparation of Microarrays for Screening of Crystal Growth Conditions”, Chait, DeLucas, Stoops, Belogvskiy.

12. “Smart Aerogel”, Daitch, Brenizer, Hosticka, Mason, Norris, Luo, DeLucas.

13. "Inhibitors of NAD Synthetase as Antibacterial Agents", Brouillette, Muccio, Jedrzejas, Brouillette, Singh, Kearney, Devedjiev, Cristofoli, and DeLucas.

14. “Uses for NAD Synthetase Inhibitors”. Brouillette, Brouillette, and DeLucas.

15. “Methods of Treating Fungal Infections with Inhibitors of NAD Synthetase Enzyme”, Brouillette, Brouillette, and DeLucas.

16. “Methods of Synthesizing and Screening Inhibitors of Bacterial NAD Synthetase Enzyme, Compounds Thereof, and Methods of Treating Bacterial and Microbial Infections with Inhibitors of Bacterial NAD Synthetase Enzyme”, Brouillette, Brouillette,

Curriculum Vitae


Devedjiev, Muccio, Jedrzejas, Cristofoli, DeLucas, Garcia, Schmitt, Velu.

17. “Improved Method for Determining Crystallization Parameters and Apparatus for Use with the Same”, Wilson, DeLucas, Henry, Lewis, Banasiewicz, Nagy, Johnson.

BOOK CHAPTERS:

1. Protein Crystal Growth Procedure for the U. S. Space Shuttle, METHODS: A Companion to Methods in Enzymology, Volume 1, No. 1, August, pp. .105 - 109 (1990).

2. Protein Crystal Growth in Space, Advances in Space Biology and Medicine, Vol. 1, pp. 249 - 278 (1991)

DOCTORAL THESIS ADVISOR:

Mike Teale 2000 Cellular & Mol. Biology

Peng Tang Pending Materials Science

Terry Bray 1997 Chemistry

Mark van der Woerd 1996 Chemistry

Matt Lawson 2005-present Interdisciplinary BioScience

Lee Joo-Hyoung 2005-present Interdisciplinary BioScience

David Johnson 2005-present Biomedical Engineering

Curriculum Vitae


MASTERS THESIS ADVISOR:

Ernie Bowling 1989 Physiological Optics

Charlotte Barnett 1989 Physiological Optics

DISSERTATION COMMITTEES:

Brad Bishop Ph. D. 1992 Chemistry

Sunghe Kim Ph.D. 1992 Biochemistry

Geeta Manwani Ph.D. 1993 Materials Science

Nancy Caterina Ph.D. 1994 Biochemistry

Christophe Nicolet Ph.D. 1995 Physiological Optics

Lan Zhou Ph.D. 1996 Microbiology

Hua Jing Ph.D. 1998 Cell. & Mol. Biology

Darin Steele Ph.D. 1999 Biochemistry

Brandon Pybus Ph.D. 2002 Chemistry

Todd Bice Ph.D. 2003 Biochem. & Mol. Genetics

Valerie Meyers Ph.D. 2004 Pathology

Eva Bernhardsdotter (UAH) Ph.D. 2004 Materials Science

Curriculum Vitae


Latisha Salaam Ph.D. 2005 Biomedical Engineering

Nicholas J. Genovese Ph.D. pending Biochem. & Mol. Biology

Joo Hyoung Lee Ph.D. pending Physiol. & Biophys.

Rashi Singal MA pending Public Health

TEACHING:

“Crystals in Space”, Bioteach, Invited Lecturer, July 15, 1996, July 8, 1998, July 28, 1999, July 19, 2000, July 12, 2002, July 16, 2004 and July 18, 2005, 2006, 2007.

"Protein Structure" as part of Integrative Biomedical Sciences (IBS-1) taught in August each year, 1999, 2000, 2001, 2002, 2003, 2004, 2005, 2006, 2007.

American Crystallographic Association Protein Crystallography Course, "Protein Crystal Growth", July 13, 1998

"Protein Structure" (Biochemistry and Molecular Genetics 734), winter quarter, 1998; spring quarter, 2000

"Protein Crystallography" as part of Cellular and Molecular Biology I class, 1995, 1996, 1997 and 1998

"Protein Crystallography", (Biochemistry and Molecular Genetics 711), 1990, 1992, 1996 and 1998

Curriculum Vitae


"Structure-Based Drug Design", School of Optometry Biochemistry Class, 1985, 1986, 1987, 1988, 1989, 1990 and 1991

Clinical Optometry Courses (General Clinic, Contact Lenses, Pediatric Diseases and Developmental Disorders, Diabetic Retinopathy), 1983, 1984, 1985, 1986, 1987, 1988, 1989, 1990, 1991 and 1992

"Protein Structure" (Biochemistry and Molecular Genetics 734), winter quarter, 2007

SYMPOSIUMS CHAIRED AND/OR ORGANIZED:

"Eighth International Conference on the Crystallization of Biological Macromolecules", Conference Co-Chairman, May 14-19, 2000, Sandestin, Florida

"Emerging Infections and Antimicrobial Resistance: Rational Approaches to Drug Design", May 30-June 1, 1997, New Orleans, Louisiana, Conference Co-Host and Invited Lecturer, "Chagas' Disease: Structure-based Drug Design"

"Structure-Based Drug Design", April 25-28, 1996, Panama City Beach, Florida

"Protein Crystal Growth", April 28-30, 1996, Panama City Beach, Florida


Curriculum Vitae


"Conference on NASA Center for the Commercial Development of Space", Albuquerque, New Mexico, January 8-12, 1995, Co-Chair of "Commercial Applications of Space Biotechnology"

AIAA/NASA Life Sciences and Space Medicine Conference and Exhibition '95, April 3-5, 1995, Houston, Texas, Co-Chair of NASA/NIAID Forum, "Host Defense and Spread of Infections in a Closed Environment"

"Structure-Based Drug Design", April 22-25, 1994, Panama City Beach, Florida


PRESENTATIONS AT SCIENTIFIC MEETINGS:

Available on request

OTHER PRESENTATIONS:

Available on request

PUBLICATIONS:

1. DeLucas, L. J., 1974, “Calcium Binding to Anionic Carbohydrates: Crystal Structure of a Hydrated Calcium-bromide Salt of Glucuronic Acid”, Alabama Journal of Medical Sciences 11: 17.

2. DeLucas, L. J., Bugg, C. E., Terzis, D., and Rivest, R., 1975, "Calcium Binding to D-Glucuronate Residues: Crystal Structure of a Hydrated Calcium Bromide Salt of D-Glucuronic Acid”, Carbohydrate Research 41:19 – 29.

Curriculum Vitae


3. DeLucas, L. J., Hearn, R. A., and Bugg, C. E., 1977, "Stacking Patterns of Thiopyrimidines: The Crystal Structure of 2-Thiocytosine Picrate”, Acta Cryst., B33:2611-2614.

4. DeLucas, L. J., Suddath, F. L., Gams, R. A., and Bugg, C. E., 1977, "Preliminary X-Ray Study of Crystals of Human Transferrin”, J. Mol. Biol., 123:285 – 286.

5. DeLucas, L. J., Gartland, G. L., and Bugg, C. E., 1978,"Sodium Binding to D-Glucuronate Residues: Crystal Structure of Sodium D-Glucuronate Monohydrate”, Carbohydrate Research 62: 213-221.

6. Parmley, R. T., Ostroy, F., Gams, R. A., and DeLucas, L. J., 1979, "Ferrocyanide Staining of Transferrin and Ferritin-Conjugated Antibody to Transferrin”, J. Histochem. & Cytochem., 27:681-685.

7. DeLucas, L. J., Einspahr, H., and Bugg, C. E., 1979, "Calcium Binding to Amide Carbonyl Groups: Structure of a Calcium Bromide Salt of D-Pantothenic Acid”, Acta Cryst., B35: 2724-2726.

8. Riordan, J., Kiely, D., DeLucas, L. J., Einspahr, H., and Bugg, C. E., 1980, "Branched-Chain Halo-Amino-Cyclytols: Synthesis and an X-Ray Crystallographic Study”, Carbohydrate Research, 82:303-324.

9. DeLucas, L. J., 1983, "How to Estimate the Edge Thickness of a Minus Lens”, The Southern Journal of Optometry, Vol. 1, No. 3.

10. DeLucas, L. J. and Muccio, D. D., 1984, "Purification of Bovine Rhodopsin Using High Performance Size Exclusion Chromatography”, Journal of Chromatography, 296, 121-128.

11. Thurschwell, L. and DeLucas, L. J., 1984, "Ischemic Optic Neuropathy”, Southern Journal of Optometry, Vol. II, p.9.

Curriculum Vitae


12. Smith, C. D., DeLucas, L. J., Ealick, S. E., Schweitz, H., Lazdunski, M. and Bugg, C. E., "Crystallization and Preliminary X-ray Investigation of a Protein Neurotoxin from the Sea Anemone Anthopleura Xanthogrammica”, J. of Biological Chemistry, 259: 8010-8011 (1984)

13. Muccio, D. D., and DeLucas, L. J., "Isolation of Detergent Solubilized Monomers of Bacteriorhodopsin by Size-Exclusion High-Performance Liquid Chromatography”, Journal of Chromatography, 326, 243-250.

14. Fullard, R., DeLucas, L. J. and Crawford, T. S. "HPLC Analysis of Proteins in Human Basal and Reflex Tears” In: "The Preocular Tear Film in Health, Disease, and Contact Lens Wear”, F. J. Holly (ed.), Dry Eye Institute, Lubbock. pp. 482-505 (1986)

15. DeLucas, L. J., Suddath, F. L., Snyder, R., Naumann, R., Broom, M.B., Pusey, M., Yost, V., Herren, B., Carter, D., Nelson, B., Meehan, E.J., McPherson, A., and Bugg, C. E., Protein Crystal Growth in Microgravity. "Proceedings Workshop on Space: Biomedicine and Biotechnology”, Canada, May 29-30,1986, pp. 81-87

16. DeLucas, L. J., et al., "Preliminary Investigations of Protein Crystal Growth Using the Space Shuttle”, J. of Crystal Growth 76: 681 - 693 (1986)

17. DeLucas, L. J., Greenhough, T. J., Rule, S. A., Myles, D. A. A., Babu, Y. S., Volanakis, J. E., and Bugg, C., "Preliminary X-ray Study of Crystals of Human C-reactive Protein”, Journal of Molecular Biology, 196: 741 - 742 (1987)

18. DeLucas, L. J., Bugg, C. E., "New Directions in Protein Crystal Growth”, Trends in Biotechnology; 5 (7): 188-193 (1987)

Curriculum Vitae


19. DeLucas, L. J., Petrash, M. and Egen, N. "Purification of Isozymes of Aldose Reductase”, Bioradiations, 67:1-4 (1988)

20. Fowlis, William. W., DeLucas, Lawrence. J., Twigg, Pamela. J., Howard, Sandra B., Meehan, Edward J, Jr., and Baird, James K. "Experimental and Theoretical Analysis of the Rate of Solvent Equilibration in the Hanging Drop Method of Protein Crystal Growth”, Journal of Crystal Growth 90: 117- 129 (1988)

21. Qing Cheng Meng, Yiu-Fai Chen, Lawrence J. DeLucas and Suzanne Oparil, "Effect of Steric Exclusion on the Separation of Proteins by Hydrophilic Size-Exclusion Chromatography”, Journal of Chromatography 445:29-36 (1988)

22. Basu, DebKumar, DeLucas, Lawrence, Parks, Elizabeth H., and Suddath, F. L. "Preliminary Crystallographic Study of the a-D-Galactose-specific Lectin from Jack Fruit Seeds”, Journal of Molecular Biology 201:661-662 (1988)

23. Qing Cheng Meng, Steven J. King, Yiu-Fai Chen, Lawrence J. DeLucas and Suzanne Oparil, "Purification of Angiotensin-Converting Enzyme by Gel High-Performance Liquid Chromatography”, Journal of Chromatography, 461:271-275 (1989)

24. Lawrence J. DeLucas, et al., "Protein Crystal Growth in Microgravity”, Science, 246:651-654 (1989)

25. L.J. DeLucas, et al., "Protein Crystal Growth in Microgravity”, Proceeds of Vllth European Symposium on Materials and Fluid Sciences in Microgravity, Oxford, UK, September 10-15,1989

26. D.A.A. Myles, S.A. Rule, L.J. DeLucas, Y.S. Babu, Y.Xu, J.E. Volanakis, C.E. Bugg, S. Bailey and T.J. Greenhough, “Rotation Function Studies of Human C-Reactive Protein”, J. Mol. Biol. 216: 491-496 (1990)

Curriculum Vitae


27. Bugg, C. E. and DeLucas, L. J., "Protein Crystal Growth in Space”, proceeding of the Space Commerce '90 Conference and Exhibition held in Montreux, Switzerland, March 26-29, 1990. Gordon and Breach Science Publishers, London, U. K. (1990)

28. DeLucas, Lawrence J. and Bugg, Charles E., “Protein Crystal Growth Procedure for the U. S. Space Shuttle”, METHODS: A Companion to Methods in Enzymology, Vol. 1, No. 1: 105 - 109, August (1990)

29. Bernard Lorber and L. J. DeLucas, "Large Scale Preparation of Homogeneous Bacteriorhodopsin”, FEBS Letters. 251: 14-18 (1990)

30. Bernard Lorber, Lawrence J. DeLucas, and J B. Bishop, "Purification of Octyl b-D-glucopyranoside and Re-estimation of its Micellar Size”, Biochem. Biophys. Acta. 1023:254-265 (1990)

31. Bernard Lorber, Lawrence J. DeLucas, and J. Brad Bishop, "Changes in the Physico-Chemical Properties of the Detergent Octyl Glucoside During Membrane Protein Crystallization Using a Salt as the Precipitant”, Journal of Crystal Growth, 110: 103-113 (1991)

32. H. Wilson Smith and Lawrence J. DeLucas, “A Method for Programmable Control of Reservoir Concentrations for Protein Crystal Growth”, Journal of Crystal Growth, 110: 137-141, (1991)

33. Lawrence J. DeLucas, et al., "Protein Crystal Growth Results for Shuttle Flights STS-26 and STS-29”, Journal of Crystal Growth, 110: 302-311 (1991)

34. Petrash, J. Mark, DeLucas, L. J., Bowling, E. and Egen, N., "Resolving Isoforms of Aldose Reductase by Preparative Isoelectric Focusing in the Rotofor”, Electrophoresis, 12: 84-90 (1991)

Curriculum Vitae


35. Bugg, Charles E. and DeLucas, L.J.,“Protein Crystal Growth in Microgravity”, Journal of Clinical Pharmacology 31: 985-987 (1991)

36. Lawrence J. DeLucas, et al., "Microgravity Protein Crystal Growth Results and Hardware”, Eighth American Conference on Crystal Growth, Vail, Colorado, Journal of Crystal Growth, 109: 12 - 16 (1991)

37. Narayana, S. V. L., Kilpatrick, J M., El-Kabbani, O., Bugg, C. E., Volanakis, J. E., and DeLucas, L. J., "Crystallization and Preliminary X-ray Investigation of Factor D of Human Complement”, Journal of Molecular Biology, 219: 1 - 3 (1991)

38. El-Kabbani, O., Narayana, S. V. L, Babu, Y. S., Moore, K. M., Flynn, T. G., Petrash, J. M., Westbrook, E. M., DeLucas, L. J. and Bugg, C. E., "Purification, Crystallization and Preliminary Crystallographic Analysis of Porcine Aldose Reductase”, Journal of Molecular Biology, 218: 695 - 698 (1991)

39. Carson, M., Narayana, S.V.L., DeLucas, L.J., El-Kabbani, O., Kilpatrick, J.M., Volanakis, J.E., and Bugg, C.E., "Modeling a Protein from Homology: Comparison with Experimental Results”, Second Conference on Applications of Computer Visualization and Imaging in Research, University of Iowa, Iowa City, Iowa, March 28 - 29, 1991

40. Lawrence J. DeLucas, et al., Proceedings of the Committee on Space Research (COSPAR) XXVIII Plenary Meeting, The Hague, The Netherlands, "Protein Crystal Growth Aboard the U. S. Space Shuttle Flights STS-31 and STS-32”, Advances in Space Research, Vol. 12, No. 1: 393-400 (1992)

41. Meng, Q. C., King, S. J., Branham, K E., DeLucas, L. J., Lorber, B., Oparil, S., "Preparative Isolation of Angiotensin-Converting

Curriculum Vitae


Enzyme from Human Lung”, Journal of Chromatography, 579: 63 - 71 (1992)

42. DeLucas, L. J., et al., "Protein Crystal Growth Results from the United States Microgravity Laboratory - 1 Mission”, Journal of Physics D: Applied Physics, 26: B100 - B103 (1993)

43. Long, M.M., DeLucas, L.J.,Smith, C., Carson, M., Moore, K., Pillion, D.J., Bishop, S.P., and Bugg, C.E., "Protein Crystal Growth in Microgravity: Temperature Induced Large Scale Crystallization of Insulin”, proceedings of the International Symposium on Microgravity Sciences and Applications, Beijing, China, May 10 - 13, 1993, Microgravity Sciences and Technology

44. El-Kabbani, O., Lin, G., Green, N.C., Flynn, T.G., and DeLucas, L.J.,“Crystal Structures of Human and Porcine Aldehyde Reductase; an Enzyme Implicated with Complications of Diabetes”, Third European Workshop on Crystallography of Biological Macromolecules, Centro di Cultura Scientifica, Como, Italy, May 24 - 28, 1993

45. El-Kabbani, O., Lin, G., Narayana, S.V.L., Green, N.C., Moore, K.M., Flynn, T.G., and DeLucas, L.J.,“Crystallization and Preliminary Structure Determination of Porcine Aldehyde Reductase from Two Crystal Forms”, Acta Cryst. D49, 490 - 496 (1993)

46. DeLucas, L.J.,et al., “Protein Crystal Growth Results from the United States Microgravity Laboratory - 1 Mission”, NASA Reference Publication (conference proceedings) from the “USML-1 and USMP-1 Joint L+1 Science Review” held September 22 - 24, 1993 in Huntsville, Alabama

Curriculum Vitae


47. DeLucas, L. J., “Protein Crystal Growth Experiments and Results”, Proceedings of the SPACEHAB-1 mission (STS-57) Experiments Symposium, NASA Headquarters, Washington, DC, October 5, 1993

48. Delbaere, L.T.J., Vandonselaar, M., Prasad, L., Pugazhenthl, U., Quail, J.W., Stojanoff, V., Sweet, R.M., Moore, K.M., and DeLucas, L.J.,"Microgravity Improvement of Protein Crystals on STS-62", Proceedings of the Spacebound '94 Conference held in Montreal, Canada, May 19-20, 1994

49. DeLucas, L.J., et al., "Recent Results and New Hardware Developments for Protein Crystal Growth in Microgravity”, Journal of Crystal Growth 135: 183 - 195 (1994)

50. Narayana, S.V.L., Yamauchi, Y., Macon, K.J., Moore, D., DeLucas, L.J. and Volanakis, J.E., “Preliminary Crystallographic Studies on Pro-factor D”, Journal of Molecular Biology 235: 1144-1146 (1994)

51. Narayana, S.V.L., Carson, M., El-Kabbani, O., Kilpatrick, J.M., Moore, D., Chen, X., Bugg, C.E., Volanakis, J.E., and DeLucas, L.J., “Structure of Human Factor D, a Complement System Protein at 2.0 Å Resolution”, Journal of Molecular Biology 235: 695-708 (1994)

52. Betzel, C., Gunther, N., Poll, S., Moore, K., DeLucas, L.J., Bugg, C.E., and Weber, W., "Crystallization of the EGF Receptor Ectodomain on U. S. Space Mission STS-47", Microgravity Science and Technology, Vol VII/3, September, pp. 242-245 (1994)

53. El-Kabbani, O., Green, N.C., Lin, G., Carson, M., Narayana, S.V.L., Moore, K., Flynn, T.G., and DeLucas, L.J., "Structures of Human and Porcine Aldehyde Reductase: an Enzyme

Curriculum Vitae


Implicated in Diabetic Complications", Acta Cryst., D50: 859-868 (1994)

54. Carson, M., Bugg, C.E., DeLucas, L.J., and Narayana, S.V.L., "Comparison of Homology Models with the Experimental Structure of a Novel Serine Protease", Acta Cryst. D50: 889-899 (1994)

55. Weidanz, J.A., Campbell, P., DeLucas, L., Jin, J., Moore, D., Roden, L., Yu, H., and Vezza, A.C., "Glucosamine-6-Phosphate Deaminase in Normal Human Erythrocytes”, British Journal of Haematology 91 (1): 72-79 (1995)

56. Weidanz, J.A., Campbell, P., Moore, D., DeLucas, L.J., Roden, L. and Vezza, A.C., "Glucosamine 6-phosphate Deaminase in Plasmodium falciparum", British Journal of Haematology 91 (3): 578-586 (1995)

57. El-Kabbani, O., Judge, K., Ginell, S.L., Myles, D.A.A., DeLucas, L.J. and Flynn, T.G., "Structure of Porcine Aldehyde Reductase Holoenzyme", Nature Structural Biology, Vol. 2, No. 8, pp. 687-692 (August, 1995)

58. El-Kabbani, O., Judge, K., Ginell, S.L., DeLucas, L.J., and Flynn, T.G., "Crystallization and Preliminary Structure of Porcine Aldehyde Reductase/NADPH Binary Complex", Acta Crystallographica D51, 605-608 (1995)

59. McDonald, W.T., Smith, C.D., Nordness, J.E., Fountain, J.A., and DeLucas, L.J., "Protein Crystallography Facility for the International Space Station", American Institute of Aeronautics and Astronautics Paper 95-3661, AIAA 1995 Space Programs and Technologies Conference and Exhibit, Huntsville, Alabama, September, 1995

Curriculum Vitae


60. Moore, K.M., and DeLucas, L.J., "Protein Crystal Growth in Microgravity", American Institute of Aeronautics and Astronautics, IAF-95-J.1.05, proceedings of the 46th International Astronautical Congress, Oslo, Norway, October 2-6, 1995

61. Nagabhushan, T.L., Reichert, P., Long, M.M., Bugg, C.E., and DeLucas, L.J., "Macroscale Production of Crystalline Interferon a-2B in Microgravity on STS-52", Proceedings of Symposium on NASA Centers for the Commercial Development of Space, Albuquerque, New Mexico, January 8-11, 1995

62. Reichert, P., Nagabhushan, T.L., Long, M.M., Bugg, C.E., and DeLucas, L.J., "Macroscale Production and Analysis of Crystalline Interferon a-2B in Microgravity on STS-52", Proceedings of Symposium on NASA Centers for the Commercial Development of Space, Albuquerque, New Mexico, January 7-10, 1996.

63. Lawson, C., Forrestall, D., Zhai, T., Shen, M., and DeLucas, L.J, "Three-Dimensional Imaging of Protein Crystals Using Optical Low Coherence Reflectometry", Microwave and Optical Technology Letters, (1996)

64. DeLucas, L.J., "International Space Station", Acta Astronautica Vol. 38, Nos. 4-8, pp. 613-619 (1996)

65. Ansari, R.R., Suh, K.I., Arabshahi, A., Wilson, W.W, Bray, T.L., and DeLucas, L.J., "A Fiber Optic Probe for Monitoring Protein Aggregation, Nucleation, and Crystallization" Journal of Crystal Growth, 168: 216-226 (1996)

66. Weidanz, J.A., Campbell, P., Moore, D., DeLucas, L., Roden, L., Thompson, J.N. and Vezza, A.C., "N-Acetylglucosamine Kinase and N-acetylglucosamine 6-Phosphate Deacetylase Activity in

Curriculum Vitae


Normal Human Erythrocytes and Plasmodium falciparum”, British Journal of Haematology 95 (4): 645-653 (1996)

67. Long, M.M., Bishop, J.B., Nagabhushan, T.L., Reichert, P., Smith, G.D., and DeLucas, L.J., "Protein Crystal Growth in Microgravity Review of Large Scale Temperature Induction Method: Bovine Insulin, Human Insulin and Human Alpha Interferon", Journal of Crystal Growth 168: 233-243 (1996)

68. Smith, C.D., Barchue, J., Mentel, C., DeLucas, L.J., Shirasawa, T., and Chattopadhyay, D., “Crystallization and Preliminary Cryogenic X-ray Diffraction Analyses of Protein L-Isoaspartyl O-Methyltransferase from Human Fetal Brain”, Proteins: Structure, Function and Genetics, 28, 457-460 (1997)

69. Asanov, A.N., DeLucas, L.J., Oldham, P.B. and Wilson, W.W., "Interfacial Aggregation of Bovine Serum Albumin Related to Crystallization Conditions Studied by Total Internal Reflection Fluorescence", Journal of Colloid and Interface Science, 196: 62-73 (1997).

70. Jindrich Symersky, Joseph M. Patti, Mike Carson, Karen House-Pompeo, Michael Teale, Dwight Moore, Lei Jin, Amy Schneider, Lawrence J. DeLucas, Magnus Höök, and Sthanam V.L. Narayana, “Structure of the Collagen Binding Domain from Staphylococcus aureus Adhesin”, Nature Structural Biology, Vol. 4, no. 10, pages 833-838, (1997)

71. Guang-da Lin, Debasish Chattopadhyay, Masatoshi Maki, Kevin K.W. Wang, Mike Carson, Lei Jin, Po-wai Yuen, Emiko Takano, Masakazu Hatanaka, Lawrence J. DeLucas, and Sthanam V.L. Narayana, “Crystal Structure of Calcium Bound Domain VI of Calpain at 1.9 Å Resolution and its Role in Enzyme Assembly, Regulation, and Inhibitor Binding”, Nature Structural Biology, Vol. 4, no. 7 pp. 539-47 (1997)

Curriculum Vitae


72. Kudryavtsev, A.B., Mirov, S.B., DeLucas, L.J., and Basiev, T.T., “Investigation of the Orientational Ordering in Tetragonal Lysozyme by Raman Method”, Bulletin of the American Physical Society, Ser. II, Vol. 42, No. 1, p. 821 (1997)

73. Nicolet, C. and DeLucas, L.J., “Simulation of Some Aspects of Microgravity in Protein Crystal Growth on Earth”, Conference on NASA Commercial Space Centers, Albuquerque, New Mexico, Conference Proceedings (1997)

74. Bray, T.L., Powell, D.L. and DeLucas, L.J., “Dynamic Control of Vapor Diffusion Protein Crystal Growth”, Conference on NASA Commercial Space Centers, Albuquerque, New Mexico, Conference Proceedings, 1997

75. Gray, R.J., Kim, L.J., DeLucas, L.J., Arabshahi, A., and Wilson, W.W., “Dynamic Temperature-Induced Crystallization of Proteins”, Conference on NASA Commercial Space Centers, Albuquerque, New Mexico, Conference Proceedings (1997)

76. McDonald, William T., Lewis, Johanna L., Smith, Craig D., and DeLucas, Lawrence J., “X-Ray Crystallography Facility for the International Space Station”, Conference on NASA Commercial Space Centers, Albuquerque, New Mexico, Conference Proceedings (1997)

77. Lin, Guang-da, Chattopadhyay, Debasish, Maki, Masatoshi, DeLucas, Lawrence J. and Narayana, Sthanam V.L., “Purification, Crystallization, and Preliminary X-ray Diffraction Studies of Recombinant Calcium-Binding Domain of the Small Subunit of Porcine Calpain”, Acta Cryst. D 53: 474-476 (1997)

78. Asanov, A.N., DeLucas, L.J., Oldham, P.B., and Wilson, W. W., “Heteroenergetics of Bovine Serum Albumin Absorption from

Curriculum Vitae


Good Solvents Related to Crystallization Conditions”, J. Colloid. Interface Sci. 191 (1): 225-235 (1997)

79. Bray, T.L., Kim, L.J., Askew, R.P., Harrington, M.D., Rosenblum, W.M., Wilson, W.W., and DeLucas, L.J., "New Crystallization Systems Envisioned for Microgravity Studies", Journal of Applied Crystallography, 31: 515-522 (1998)

80. Moore, D., Bice, T., Jin, L., Grandhi, A., DeLucas, L.J., and Narayana, S.V.L., “Crystallization and Preliminary Crystallographic Investigation of Porcine Quinolinate Phosphoribosyltransferase”, Acta Cryst D54: 119-120 (1998)

81. Kudryavtsev, A.G., Mirov, S.B., DeLucas, L.J., Nicolete, C., van der Woerd, M., Bray, T. L., and Basiev, T. T., “Polarized Raman spectroscopic studies of tetragonal lysozyme single crystals”, Acta Cryst. D54: 1216-1229 (1998)

82. Chattopadhyay, D., Stewart, J.E., and DeLucas, L.J., “Large-Scale Preparation of the D10 Form of Staphylokinase by in vitro Processing of Recombinant Staphylokinase with Purified Human Plasminogen”, Appl. Biochem. and Biotech., Vol. 69, pp 147-156 (1998)

83. Ke, S.C., DeLucas, L.J. and Harrison, J.G., "Computer Simulation of Protein Crystal Growth Using Aggregates as the Growth Unit", J. Phys. D.: Applied Physics 31: 1064-1070 (1998)

84. Kudryavtsev, A.B., Mirov, S.B., DeLucas, L.J. and Basiev, T.T., "Polarized Raman Spectroscopy of Disulfide Bonds in Tetragonal Lysozyme Single Crystals", Proceedings of the 7th International Conference on the Crystallization of Biological Macromolecules, Granada, Spain, May 3-8, 1998, pg. 80

Curriculum Vitae


85. Haddox, J.L., Pfister, R.R., Muccio, D.D., Villain, M., Sommers, C.I., Chaddha, M., Anantharamaiah, G.M., Brouillette, W.J. and DeLucas, L.J.,“Bioactivity of Peptide Analogs of the Neutrophil Chemoattractant, N-Acetyl-Proline-Glycine-Proline”, Investigations in Ophthalmology and Visual Science 40:2427-2429 (1998)

86. Moore, K.M., Long, M.M. and DeLucas, L.J., “Protein Crystal Growth in Microgravity: Status and Commercial Implications”, Space Technology and Applications International Forum-1999, #CP458, The American Institute of Physics (1999)

87. Deivanayagam, C.C.S., Rich, R.L., Danthuluri, S., Owens, R.T., Patti, J.M., Höök, M., DeLucas, L.J. and Narayana, S.V.L., “Crystallization and Preliminary X-ray Analysis of B-domain Fragments of a Staphylococcus aureus Collagen-Binding Protein”, Acta Cryst D 55: 525-527 (1999)

88. Barchue, J., Symersky, J., Narayana, S.V.L., Moore, J.K., DeLucas, L.J. and Chattopadhyay, D., “Expression, Purification, Crystallization and Preliminary X-ray Diffraction Analysis of Uracil Phosphoribosyltransferase of Toxoplasma gondii”, Acta. Cryst. D 55: 347-349 (1999)

89. Jing, H., Macon, K.J., Moore, D., DeLucas, L.J., Volanakis, J.E. and Narayana, S.V.L., “Structural Basis of Profactor D Activation: From a Highly Flexible Zymogen to a Novel Self-Inhibited Serine Protease, Complement Factor D”, EMBO J, 18:804-814 (1999)

90. Carolyn Ozment, Joseph Barchue, Lawrence J. DeLucas, and Debasish Chattopadhyay, “Structural Study of Escherichia coli NAD Synthetase: Overexpression, Purification, Crystallization, and Preliminary Crystallographic Analysis”, Journal of Structural Biology, 127:279-282 (1999)

Curriculum Vitae


91. Lawrence J. DeLucas, Karen M. Moore, and Marianna M. Long, "Protein Crystal Growth and the International Space Station", Gravitational and Space Biology Bulletin, Vol. 12, No. 2, 39-45 (1999)

92. Sergey B. Mirov, Robert E. Pitt, Alex Dergachev, Wonwoo Lee, Dmitri V. Martyshkin, Elga D. Mirov, Jeremy J. Randolph, Lawrence J. DeLucas, Christie G. Brouillette, Tasoltan T. Basiev, Yuri V. Orlovskii, Olimkhon, K. Alimov, and Ivan N. Vorob'ev, "A novel laser breakdown spectrometer for environmental monitoring", SPIE Vol. 3855, 34-41 (1999)

93. R. Recacha, W. M. Carson, M.Costanzo, B. Maryanoff, L. J. DeLucas and D. Chattopadhyay, "Crystal Structure of RWJ 51084-Trypsin at 1.8Å Resolution" Acta Cryst. D55:1785-1791 (1999)

94. Jindrich Symersky, Jan Novak, David T. McPherson, Larry DeLucas and Jiri Mestecky, "Expression of the recombinant human immunoglobulin J. chain in Escherichia coli", Molecular Immunology 37:133-140 (1999)

95. R. Recacha, A. Talalaev, L. J. DeLucas and D. Chattopadhyay, "Toxoplasma gondii Adenosine Kinase: Expression, Purification, Characterization, Crystallization and Preliminary Crystallographic Analysis", Acta Cryst D56, 76-78 (1999)

96. W. J. Cook, L. J. DeLucas & D. Chattopadhyay, "Crystal Structure of adenosine kinase from Toxoplasma gondii at 1.8Å Resolution", Prot. Sci. 9, 704-712 (2000)

97. Lorenz, S., Perbandt, M., Lippmann, C., Moore, K., DeLucas, L.J., Betzel, C., and Erdmann, V. A., “Crystallization of engineered Thermus flavus 5S rRNA under earth and microgravity conditions”, Acta Cryst D56: 498-500 (2000)

Curriculum Vitae


98. R. Recacha, W. M. Carson, M. Costanzo, B. Maryanoff, L. J. DeLucas and D. Chattopadhyay, "Crystal Structure of Human a-Thrombin RWJ-51438 at 1.7Å: Unusual Perturbation of the 60A-60I Inspection Loop", Acta Cryst D56:1395-1400, (2000)

99. D. Chattopadhyay, G. Langsley, M. Carson, R. Recacha, L. J. DeLucas and C. D. Smith, "Crystal structure of the Nucleotide Binding Domain of Plasmodium falciparum Rab6 GTPase in the GDP Bound Form", Acta Cryst D56, 937-944 (2000)

100. Lawrence J. DeLucas, Marianna M. Long, Karen M. Moore, Michael Harrington, William T. McDonald, Craig D. Smith, Terry Bray, Johanna Lewis, William B. Crysel, and Lance D. Weise, "Protein Crystal Growth Studies at the Center for Macromolecular Crystallography", Proceedings of the STAIF Conference, Albuquerque, New Mexico, January 30-February 3, 2000

101. Yancho Devedjiev, Jindrich Symersky, Raj Singh, Marek Jedrzejas, Christie Brouillette, Wayne Brouillette, Donald Muccio and Larry DeLucas, “Stabilization of active site loops in NH3-dependent NAD+ synthetase from Bacillus subtilis”, Acta Cryst. D57:806-812, (2001)

102. Gourinath S., Degenhardt M., Eschenburg S., Moore K., DeLucas L.J., Betzel C. and Singh T.P., “Mercury induced modifications in the stereochemistry of the active site through Cys-73 in a serine protease-crystal structure of the complex of a partially modified proteinase K with mercury at 1.8Å resolution, Indian J. Biochem. Biophys., 38(5):298-302, 2001.

103. DeLucas, Lawrence J., “Protein crystallization – is it rocket science?”, Drug Discovery Today 6(14), 734-744, 2001

Curriculum Vitae


104. Smith C.D., Carson M., Friedman A., Skinner M.M., DeLucas L., Chantalat L., Weise L., Shirasawa T., and Chattopadhyay D. (2002) “Crystal Structure of Human L-Isoaspartyl-O-Methyltransferase with S-Adenosyl Homocysteine at 1.6Å Resolution and Modeling of an Isoaspartyl Containing Peptide at the Active Site.” Protein Science 11, 625-635.

105. Krauspenhaar, R., Rypniewski, W., Kalkura, N., Moore, K., DeLucas, L., Stoeva, St., Mikhailov, A., Voelter, W., and Betzel, Ch., “Crystallisation under microgravity of mistletoe lectin I from Viscum album with adenine monophosphate and the crystal structure at 1.9Å resolution”, Acta Cryst D. 58:1704-1707, 2002.

106. Vallazza M., Banumathi, S., Perbandt, M., Moore, M., DeLucas, L., Betzel, Ch., Erdmann, V. A., “Crystallization and structure analysis of Thermus flavus 5S rRNA helix B’, Acta Cryst D, 58:1700-1703, 2002.

107. J. Symersky, Y. Devedjiev, K. Moore, C.G. Brouillette, L.J. DeLucas, NH3-dependent NAD+ synthetase from Bacillus subtilis at 1Å resolution, Acta Cryst D58:1138-1146, 2002.

108. S. Li, J. Finley, Z.J. Liu, S.H. Qiu, H. Chen, C.H. Luan, M. Carson, J. Tsao, W. Thomas, L.A. Nagy, B. Sha, L. J. DeLucas, B. C. Wang and M. Luo (2002), Structural genomics of Caenorhabditis elegans: The structure of cytoskeleton-associated protein (CAP-Gly) domain of F53F4.3. J. Biol. Chem, 277:48596-48601.

109. Chernov A.A. and DeLucas L. J., “View on biocrystallization from Jena, 2002”, Acta Crystallogr D Biol. Crystallogr. 58(Pt 10): 1511-1513, 2002.

Curriculum Vitae


110. Ramadan M.A., Shrive A.K., Holden D., Myles D. A., Volanakis J.E., DeLucas, L.J., and Greenhough T. J., “The three-dimensional structure of calcium-depleted human C-reactive protein from perfectly twinned crystals”, Acta Crystallogr D Biol. Crystallogr, 58(Pt 6):992-1001, 2002.

111. Lawrence J. DeLucas, Terry L. Bray, Lisa Nagy, Debbie McCombs, Nikolai Chernov, David Hamrick, Larry Cosenza, Alexander Belgovskiy, Brad Stoops, and Arnon Chait, “Efficient Protein Crystallization”, J. Structural Biology, 142:188-206, 2003.

112. Michael W. W. Adams, Harry A. Dailey, Lawrence J. DeLucas, Ming Luo, James H. Prestegard, John P. Rose, and Bi-Cheng Wang, “The Southeast Collaboratory for Structural Genomics: A High-Throughput Gene to Structure Factory”, Accounts of Chemical Research, 36 (3):191-198, 2003.

113. Marcus Padow, Lilin Lai, Champion Deivanayagam, Lawrence J. DeLucas, Robert B. Weiss, Diane M. Dunn, Xiaoyun Wu, and John C. Kappes, “Replication of Chimeric Human Immunodeficiency Virus Type 2 (HIV-1) Containing HIV-2 Integrase (IN): Naturally Selected Mutations in IN Augment DNA Synthesis”, Journal of Virology, 77(20):11050-11059, 2003.

114. Sadanandan E. Velu, Walter A. Cristofoli, Gabriet J. Garcia, Christie G. Brouillette, Milton C. Pierson, Chi-Hao Luan, Lawrence J. DeLucas, and Wayne J. Brouillette, “Tethered Dimers as NAD Synthetase Inhibitors with Antibacterial Activity”, J. Med. Chem, 46:3371-3381, 2003.

115. Padowww J., Lai L., Deivanayagam C., DeLucas L.J., Weiss R.B., Dunn D.M., Wu X, and Kappes J.C., “Replication of chimeric human immunodeficiency virus type 1 (HIV-1) containing HIV-2 integrase (IN): naturally selected mutations in

Curriculum Vitae


IN augment DNA synthesis”, J. Virol., 77(20):11050-11059, 2003.

116. Sing H., Qiu S., Bunzel R.J., Luo D., Arabashai A., Lu S., Symersky J., Nagy L.A., DeLucas L.J., Li S., and Luo M., “Purification, nanocrystallization and preliminary X-ray analysis of a C-terminal part of tropomodulin protein 1, isoform A., from Caenorhabditis elegans”, Acta Crystallogr D Biol. Crystallogr., 59(Pt 6):1106-1108, 2003.

117. Luan C.H., Qiu S., Finley J.B., Carson M., Gray R.J., Huang W., Johnson D., Tsao J., Reboul J., Vaglio P., Hill D.E., Vidal, M., DeLucas L. J. and Luo M., “High-throughput expression of C. elegans proteins”, Genome Res. 10B:2102-2110, 2004.

118. Yang Z.W., Tendian S.W., Carson W.M., Brouillette W. J., DeLucas L.J. and Brouillette C.G., “Dimethyl sulfoxide at 2.5% (v/v) alters the structural cooperativity and unfolding mechanism of dimeric bacterial NAD+ synthetase”, Protein Sci, 12(3):830-841, 2004.

119. Lawrence J. DeLucas, Christie G. Brouillette, Shawn McDonald and Kal Ramnarayan “Tools for Structural Genomics: Accelerating the Structure Pipeline”, Drug Discovery World, summer issue, 65-72, 2004.

120. DeLucas, L.J., David Hamrick, Larry Cosenza, Lisa Nagy, Debbie Powell, Terry Bray and Arnon Chait, “Protein Crystallization: Virtual Screening and Optimization”, Progress in Biophys. and Mol. Biol., 88:285-309, 2005.

121. Velu, Sadanandan E., Chi-Hao Luan, Lawrence J. DeLucas, Christie G. Brouillette and Wayne J. Brouillette, “Tethered Dimer Inhibitors of NAD Synthetase: Parallel Synthesis of an Aryl-Substituted SAR Library”, J. Comb. Chem., 7:898-904, 2005.

Curriculum Vitae


122. Wang BC, Adams MW, Dailey H, DeLucas L, Luo M, Rose J, Bunzel R, Dailey T, Habel J, Horanyi P, Jenney FE Jr, Kataeva I, Lee HS, Li S, Li T, Lin D, Liu ZJ, Luan CH, Mayer M, Nagy L, Newton MG, Ng J, Poole FL 2nd, Shah A, Shah C, Sugar FJ, Xu H. “Protein production and crystallization at SECSG -- an overview,” J Struct Funct Genomics, 6(2-3):233-43, 2005.

123. Velus, S.E., Luan, C.H., DeLucas, L.J., Brouillette, C.G., Brouillette, W.J. “Tethered dimer inhibitors of NAD synthetase: parallel synthesis of an aryl-substituted SAR library”, J Comb Chem., Nov-Dec;7(6):898-904, 2005.

124. Schormann N, Pal B, Senkovich O, Carson M, Howard A, Smith C, Delucas L, Chattopadhyay D. “Crystal structure of Trypanosoma cruzi pteridine reductase 2 in complex with a substrate and an inhibitor”, J Struct Biol., Oct;152(1):64-75, 2005.

125. Rypniewski, W., Vallazza, M., Perbandt, M., Klussmann, S., DeLucas, L.J., Betzel, C., Erdmann, V.A. “The first crystal structure of an RNA racemate”, Acta Crystallogr D Biol Crystallogr., Jun;62(Pt 6):659-64, 2006.

126. Wu, Y., McCombs, D., Nagy, L., DeLucas, L.J., Sha, B. “Preliminary X-ray crystallographic studies of yeast mitochondrial protein Tom70p”, Acta Crystallograph Sect F Struct Biol Cryst Commun., Mar 1;62(Pt 3):265-7, 2006.

127. Josyula, R., Jin, Z., McCombs, D., DeLucas, L.J., Sha, B. “Preliminary crystallographic studies of yeast mitochondrial peripheral membrane protein Tim44p”, Acta Crystallograph Sect F Struct Biol Cryst Commun., Feb 1;62(Pt 2):172-4, 2006.

Curriculum Vitae


128. McDonald, H.M., Pruet, P.S., Deivanayagam, C., Protasevich, I.I., Carson, W.M., Delucas, L.J., Brouillette, W.J., Brouillette, C.G. ”Structural adaptation of an interacting non-native C-terminal helical extension revealed in the crystal structure of NAD(+) synthetase from Bacillus anthracis”, Acta Crystallogr D Biol Crystallogr., Aug;63(Pt 8):891-905, 2007.

129. Schormann, N., Grigorian, A., Samal, A., Krishnan, R., Delucas, L., Chattopadhyay, D. “Crystal structure of vaccinia virus uracil-DNA g l y c o s y l a s e r e v e a l s d i m e r i c a s s e m b l y ” , BMC Struct Biol., Jul 2;7:45, 2007.

130. Velu, S.E., Mou, L., Luan, C.H., Yang, Z.W., DeLucas, L.J., Brouillette, C.G., Brouillette, W.J. “Antibacterial nicotinamide adenine dinucleotide synthetase inhibitors: amide- and ether-linked tethered d i m e r s w i t h a l p h a - a m i n o a c i d e n d g r o u p s , ” J Med Chem., May 31;50(11):2612-21, 2007.

131. Samal, A., Schormann, N., Cook., W.J., DeLucas, L.J., Chattopadhyay, D. “Structures of vaccinia virus dUTPase and its nucleotide complexes,” Acta Crystallogr D Biol Crystallogr., May;63(Pt 5):571-80, 2007.

132. Carson, M., Johnson, D.H., McDonald, H., Brouillette, C., DeLucas, L.J. “His-tag impact on structure”. Acta Crystallogr D Biol Crystallogr., Mar;63(Pt 3):295-301, 2007.

Curriculum Vitae


cv dr. lawrence j. delucas - space island group · dr. lawrence j. delucas curriculum vitae name:...

Documents