curriculum vitae.doc

CURRICULUM VITAERichard Brian Alexander, M.D.

Professor

Division of UrologyUniversity of Maryland School of Medicine419 W. Redwood Street, Suite 320Baltimore, MD 21201410-328-5109410-328-7813 [email protected]

Education

1978 B.A., The Johns Hopkins University, Baltimore, Maryland. Major: Natural Sciences Area Major, part of 2-5 Accelerated Medical School Program, Johns Hopkins School of Medicine

1981 M.D., The Johns Hopkins University School of Medicine, Baltimore, Maryland. Enrolled in combined 2-5 Accelerated Medical School Program

Post-Graduate education

7/81-6/83 Resident in General Surgery, Department of Surgery, Vanderbilt University Affiliated Hospitals, Nashville, Tennessee.

7/83-6/84 Research Fellow, Department of Urology, The Johns Hopkins Hospital, Baltimore, Maryland.

7/84-12/87 Resident in Urology, Department of Urology, The Johns Hopkins Hospital, Baltimore, Maryland.

1/88-6/88 Instructor, Department of Urology, The Johns Hopkins Hospital, Baltimore, Maryland.

7/88-3/90 Senior Staff Fellow (Post-doctoral fellowship), Surgery Branch, National Cancer Institute, Bethesda, Maryland.

Certification

1991 Diplomate, American Board of Urology.

Licensure

1983 Physician and Surgeon, State of Maryland.

mailto:[email protected]

Richard B. Alexander, M.D.Curriculum Vitae

Military Service

None

Employment history

3/90-3/94 Senior Investigator, Surgery BranchNational Cancer Institute, Bethesda, Maryland.

3/94-7/98 Associate Professor of Surgery/Urology, tenure trackUniversity of Maryland School of Medicine.

7/98-7/05 Associate Professor of Surgery/Urology with tenureUniversity of Maryland School of Medicine

7/05 Professor of Surgery/Urology with tenureUniversity of Maryland School of Medicine

Associated hospital appointments

3/94-present Chief of Urology, VA Maryland Health Care System, Baltimore, Maryland

3/94-present Attending Urologist, University of Maryland Medical SystemBaltimore, Maryland.

Professional memberships

1988-present Society for Basic Urological Research.

1991-present American Association of Immunologists.

1991-present Mid-Atlantic Section, American Urological Association.

1992-present American Urological Association.

1998-present American Association for Cancer Research

2003-present Society of University Urologists

2004-present International Society for Biologic Therapy of Cancer

Honors and awards

1974 Captain Newton H. White Scholar, Johns Hopkins University.

1976 Combined B.A.-M.D. program, Johns Hopkins University School of Medicine.


1978 Election to Phi Beta Kappa.

1978 Graduation with honors, Johns Hopkins University.

1985 American Cancer Society Clinical FellowshipThe Johns Hopkins Hospital.

1987 Francis Schwentker Award for housestaff research, The Johns Hopkins Hospital.

1988 Dornier American Urological Association Scholar.

1990 Upjohn Young Investigator Award, American Association for Cancer Research.

1996 American Urological Association-European Association of Urology Academic Fellowship Program, Alternate.

Administrative Service

Institutional Service

1995-2000 VAMHCS Pharmacy and Therapeutics Committee

1996-2000 VA VISN Pharmacy and Therapeutics Committee

2000-2004 Member, UM School of Medicine Honor Board

2003-persent Member, UM School of Medicine Institutional Review Board

2004-present Member, VA Advanced Clinic Access Committee

Local Service

2002- present Counselor, Johns Hopkins Medical and Surgical Association Board of Counselors. Manages the activities of the Johns Hopkins Medical and Surgical Association, an alumni organization for graduates of Johns Hopkins School of Medicine and Post-Doctoral Fellows and residents in the Johns Hopkins Medical Institutions.

3/2003 Course Director, Maryland Urological Association Annual Meeting, Held at University of Maryland, attended by Members and urologists from Maryland, Virginia, Delaware and Washington, DC. Directed activities of local and national lecturers, arranged certification for CME credits, made all local arrangements for visiting professor and resident presentations.


National Service

1994-present Consultant Surgeon, Surgery Branch, National Cancer Institute and Clinical Center, National Institutes of Health, Bethesda, Maryland

1995-present U.S. Food and Drug Administration, Office of Orphan Products Development ad hoc Oncology Review Panel.

1995 Panel member and plenary speaker, NIDDK-convened Consensus Development Conference on Chronic Prostatitis/Chronic Pelvic Pain Syndrome, Bethesda, MD.

1996-1999 Member, National Cancer Institute PDQ Adult Treatment Advisory Editorial Board.

1997 American Foundation for Urologic Disease/American Urological Association Research Grants Review Committee.

1997-1999 Member, Research Committee, American Urological Association.

2000 Course faculty, American Urological Association Instructional Course, Use of the NIH-CPSI in practice. Responsible for development of course curriculum and presentation of instruction for this course at AUA national meeting.

2001 to 2002 Course Director, American Urological Association Instructional Course, Evaluation and Management of Prostatitis. Responsible for development of course curriculum and presentation of instruction for this course at AUA national meeting.

2001-2003 Member, Medical Research Advisory Group, US Department of Veterans Affairs. National committee organized to review and advise VA Central Office on Medical Research portfolio within the US Department of Veterans Affairs at the national level.

2001-present Member, External Advisory Committee, BACH survey, an NIDDK-funded Boston area health survey of urologic diseases. The group provides oversight and scientific guidance for this large, population-based survey of urologic symptoms.

2002-present Co-chairman and member of executive committee, Chronic Prostatitis Collaborative Research Network Steering Committee. Leadership position determining course of international, multi-center, NIH-funded study group for chronic prostatitis.

2002-present Abstract reviewer, American Urological Association Annual Meeting, “Infection and Inflammation.”


10/2003 Member of Blue-Ribbon advisory panel to NIDDK for long term goal planning for research in interstitial cystitis. Invited participant in 2 day Consensus Conference, Bethesda, MD.

2003 Member, Program Committee, Mid-Atlantic American Urological Association Annual Meeting.

2004 Reviewer, VA Oncology Committee B for Merit Review Grant applications.

5/2005 Moderator, poster session “Infections/inflammations of the genitourinary tract’” American Urological Association Annual Meeting, San Antonio, TX.

Editorial Tasks

2005-present Member, Editorial Board, Journal of Urology (Investigative Urology Section).

Reviewer, 1994-present

Journal of Immunology

Journal of Urology

Urology

Journal of Immunotherapy

Cancer Research

Prostate

Journal of the American Medical Association (JAMA)

Teaching responsibilities

Basic Sciences

1995-1997 Doctoral thesis advisory committee, UMBC Biology graduate student Todd Armstrong. This involves committee meetings for review of thesis work and defense of thesis and advisory activities for the Ph.D. candidate relating to his research program. Todd earned the Ph.D. degree and is pursuing an academic research career at Johns Hopkins.

1995 Research mentor for Urology resident Kevin Brewton. This involves supervising and mentoring a Urology resident during a research year in my laboratory.


1996 Research mentor for Urology resident C.R. Orth. This involves supervising and mentoring a Urology resident during a research year in my laboratory.

1996-1997 Laboratory mentor for Medical Student Eric Friedman. Mr. Friedman spent a year in my laboratory before his fourth year of Medical School at Hershey. He was directly supervised and mentored by me during this time. He earned a travel award for his research presentation at the annual meeting of the Mid Atlantic Section, American Urological Association. He went on to train in Radiation Oncology and is currently pursuing a career in Academic Medicine.

1998 Lecture to second year medical school class “Tumor Immunology,” part of second year microbiology course. This service involved the preparation of a lecture to the entire second year Medical School class, creation of a syllabus and slides for web posting and delivery of the lecture to the class. This was planned as a permanent part of the microbiology course but the curriculum was changed after that year.

1998 Research mentor for Urology resident Alex Rodriguez. This involves supervising and mentoring a Urology resident during a research year in my laboratory.

1996 – present Lecturer, UMB Pathology Graduate Course 760 “Pathobiology of Cancer” Course Director: Amy Fulton. This lecture is a part of the curriculum of this course which continues annually. This involves the selection by me of two papers from the current literature for review and discussion by me with the graduate student enrollees in the course.

1996-1998 Faculty mentor for full time post-doctoral fellow Sathibalan Ponniah, Ph.D. I mentored Dr. Ponniah who worked in my laboratory during this fellowship. Dr. Ponniah went on to pursue a career in academic cancer research and currently holds a faculty position at the Uniformed Services University of the Health Sciences in Bethesda, MD.

1997 Doctoral thesis advisory committee, UMBC Biology graduate student Vicky Gunther. This involves committee meetings for review of thesis proposal and defense of dissertation and advisory activities for the Ph.D. candidate relating to her research program.

1999-2001 Faculty mentor for full time post-doctoral fellow Elena Klyushnenkova, Ph.D. Dr. Klyushnenkova was mentored by me and worked in my laboratory during this fellowship. She went on to pursue a career in academic cancer research first at the NCI Frederick Cancer Research Facility but then returned to once again join my laboratory at UM as Assistant Professor of Surgery/Urology in the School of Medicine. I am guiding her development as an independent investigator.


2003-present Doctoral thesis advisory committee, UMBC Biology graduate student Stephanie Bunt

2004 Research mentor for Urology resident Todd Oberle. This involves supervising and mentoring a Urology resident during a research year in my laboratory.

Clinical Sciences

1994-2000 3rd and 4th year Medical Student Surgery Clerkship lecturer, monthly, “Genitourinary Malignancies”

1997 Mentor for Visiting Medical Student Ben Chew. I advised and guided him during his UM experience. Dr. Chew went on to complete residency and fellowship training in Urology and is pursuing a career in academic Urology in Canada.

1999-present Clinical correlation instructor: First year medical student anatomy course: Pelvic and perineal dissections.

2003 Faculty mentor for third year medical student Gretchen Dickinson. Ms. Dickinson shadowed me in all clinical and research activities for one week.

2003-present Small group B discussion group instructor. Third year surgery clerkship students. This involves delivering a one hour presentation to student discussion group of 6-10 third year medical students on three topics each quarter, “Hematuria and Renal Calculi,” “Voiding Dysfunction and BPH” and “Genitourinary Malignancies.” Ongoing.

Grant Support

Completed Grant Support

1994 Alexander, RB, Principal Investigator. Immunotherapy for prostatic cancer, American Cancer Society Institutional Research Grant #IRG-147, University of Maryland at Baltimore. Total direct costs: $5,950.

1995 Alexander, RB, Principal Investigator. Cryosurgical ablation of the prostate and systemic immune responses to prostatic cancer in rats, Special Research Initiative Support, University of Maryland School of Medicine. Total direct costs: $15,000.

1995-1997 Alexander, RB, Principal Investigator. Development of cell-mediated immunity to prostatic cancer, U.S. Department of Veterans Affairs Research Advisory Group. Total direct costs: $110,000.


1997-2000 Alexander, RB, Principal Investigator. Antigenicity of human prostatic proteins in prostatic cancer. U.S. Department of Veterans Affairs Merit Review Grant. Total direct costs: $310,000.

10/01/97-9/30/03 Alexander, RB, Principal Investigator. Chronic prostatitis collaborative clinical studies. NIH/NIDDK R01DK53732-01. Total direct costs: $956,007

10/01/98-9/30/00 Alexander, RB, Co-investigator. Prostate tumor antigen discovery. Development of a novel genetic approach, Dean Mann, Principal Investigator. U.S. Army Medical Research and Materiel Command. Total direct costs: $608,760.

4/01/99-3/31/03 Alexander, RB, Principal Investigator. Randomized, prospective, placebo-controlled trial of Enbrel (etanercept) for chronic prostatitis. Immunex Corporation. Total direct costs award: $100,000.

Active Grant Support

10/1/01-9/30/05 Alexander, RB, Principal Investigator. Identification of immunogenic MHC class II-restricted peptides from PSA. U.S. Department of Veterans Affairs Merit Review Grant. Total direct costs: $600,000.

9/1/02 – 8/31/08 Alexander, RB, Co-investigator. Alternative Therapies for Benign Prostatic Symptoms, DK63778, Michael Naslund, Principal Investigator. NIH/NIDDK. Annual direct costs $341,666

6/1/01 – 5/31/06 Alexander, RB, Co-investigator Effects of stretch on IC and normal urothelia, DK-59441, Toby Chai, Principal Investigator. NIH/NIDDK Annual direct costs $175,000

7/1/03-6/30/08 Alexander, RB, Principal Investigator, Chronic prostatitis collaborative clinical studies. NIH/NIDDK, DK 65268, total direct costs $1,329,793.

6/1/01 – 5/31/06 Alexander, RB, Co-investigator. Interstitial Cystitis Clinical Research Network. DK65271, Toby Chai, Principal Investigator, NIH/NIDDK Annual direct costs $257,889.

9/1/04-8/31/06 Alexander, RB, Principal Investigator, NCI CTEP protocol #6991, A Phase 2 Study of Prostate Specific Antigen Peptide 3A (PSA: 154-163(155L) ) (NSC # 722932, IND#9787) with Montanide ISA-51(NSC #675756, IND #9787) Vaccination in Prostate Cancer Recurrent. Translational Research Initiative funding. Direct costs $68,293 for laboratory endpoints.

Pending grant support

3/1/05-2/28/08 Alexander, RB, Principal Investigator, Autoimmunity in chronic


prostatitis, Ancillary study proposal to NIDDK, Total direct costs $292,797.

7/1/05-6/31/08 Alexander, RB, Co-investigator, Prostate cancer immunotherapy using prostate differentiation antigens, Elena Klyushnenkova, Principal Investigator. VA Merit Review Grant application. Total annual direct costs $150,000.

7/1/04-6/30/09 Alexander, RB, Principal Investigator. Immunogenic peptides for prostate cancer immunotherapy. NIH/NIDDK. R01 application submitted 11-1-04. Total direct costs: $900,000

Patents and inventions

January 30, 2001 U.S. Patent 6,180,355 Method for diagnosing and treating chronic pelvic pain syndrome. Alexander, RB. and Ponniah, S., Inventors

August, 2004 ORD disclosure “Immunogenic peptides from PSA for the treatment of prostate cancer”. Alexander, RB, Klyushnenkova, EV and Vandenbark, AA, inventors. Provisional U.S. patent application submitted by ORD August, 2004.

Publications

Book Chapters1. Alexander, R.B. and Rosenberg, S.A. Tumor necrosis factor: Clinical applications. in

Biologic Therapy of Cancer, edited by V.T. DeVita, S. Hellman and S.A. Rosenberg, J.B. Lippincott Company, Philadelphia, 1991, pp. 378-391.

2. Alexander, R.B. Tumor necrosis factor and chemotherapeutic drugs targeted at DNA topoisomerase II for the treatment of genitourinary malignancies. in Therapy for Genitourinary Cancer, edited by H. Lepor and R. K. Lawson, Kluwer Academic Publishers, Norwell, MA, 1992, pp. 105-120.

3. Alexander, R.B., Walther, MM, Linehan, WM, Rosenberg, SA. Immunotherapy of renal cell carcinoma. Experience of the Surgery Branch, National Cancer Institute. in Advances in Urology, Volume 6, edited by B. Lytton, W.J. Catalona, L.I. Lipshultz and E.J. McGuire, Mosby Year Book, Chicago, 1993, pp. 101-125.

4. Alexander, R.B., Linehan, WM, and Rosenberg, SA. Immunotherapy of renal cell carcinoma: Surgery Branch, NCI experience. A.U.A. Updates, Volume XIV, lesson 40, 1995.

5. Alexander, R.B. Immunotherapy: General principles. in Urologic Oncology, edited by Oesterling, J. E. and Richie, J. P., W. B. Saunders, Philadelphia, 1997, pp. 88-100.

6. Alexander, R.B. Evaluation of the patient. In Prostatitis, edited by Nickel, J.C., Isis Medical Media, Oxford, England, 1999, pp. 179-186.

Peer-reviewed Journal Articles1. Alexander, R.B., Isaacs, W.B. and Barrack, E.R. Immunogold probes for electron


microscopy: Evaluation of staining by fluorescence microscopy. J. Histochem. Cytochem. 33:995-1000, 1985.

2. Alexander, R.B. and Coffey, D.S. Future developments and new research in genitourinary cancers: Perspectives. American Cancer Society Conference on Urologic Cancer 1986. Cancer 60:686-690, 1987.

3. Alexander, R.B., Greene, G.L. and Barrack, E.R. Estrogen receptors in the nuclear matrix: Direct demonstration using monoclonal anti-receptor antibody. Endocrinology 120:1851-1857, 1987.

4. Alexander, R.B., Nelson, W.G. and Coffey, D.S. Synergistic enhancement by tumor necrosis factor of in vitro cytotoxicity from chemotherapeutic drugs targeted at DNA topoisomerase II. Cancer Res. 47:2403-2406, 1987.

5. Alexander, R.B., Isaacs, J.T. and Coffey, D.S. Tumor necrosis factor enhances the in vitro and in vivo efficacy of chemotherapeutic drugs targeted at DNA topoisomerase II in the treatment of murine bladder cancer. J. Urology 138:427- 429, 1987.

6. Alexander, R.B., Maguire, M.G., Epstein, J.E. and Walsh, P.C. Pathologic stage is higher in older men with clinical stage B1 adenocarcinoma of the prostate. J. Urology 141:880-882, 1989.

7. Isaacs, W.B., Isaacs, J.T., Kyprianou, N., Burgers, J.K., Alexander, R.B., Partin, A.W., Mohler, J.L., Marshall, F.F., and Coffey, D.S. New approaches to the evaluation of the metastatic ability of renal cancer and new approaches to chemotherapy. Eur Urol 18(Suppl 2):33-5, 1990.

8. Giaccone, G., Kadoyama, C., Alexander, R.B. and Gazdar, A.F. Tumor necrosis factor alone and combined with adriamycin or etoposide in the treatment of human lung cancer cell lines. Int. J. Cancer 46:326-329, 1990.

9. Rosengard, B.R., Kortz, E.O., Guzzetta, P.C., Sundt III, T.M., Ojikutu, C.A., Alexander, R.B. and Sachs, D.H. Transplantation in miniature swine: Analysis of graft infiltrating lymphocytes provides evidence for local suppression. Human Immunol. 28:153-158, 1990.

10. Alexander, R.B. and Rosenberg, S.A. Long term survival of adoptively transferred tumor infiltrating lymphocytes in mice. J. Immunol. 145:1615-1620, 1990.

11. Wong, R.A., Alexander, R.B., Puri, R.J., and Rosenberg, S.A. In vivo proliferation of adoptively transferred tumor infiltrating lymphocytes in mice. J. Immunother. 10:120-130, 1991.

12. Kyprianou, N., Alexander, R.B. and Isaacs, J.T. Activation of programmed cell death by recombinant human tumor necrosis factor plus topoisomerase II- targeted drugs in L929 tumor cells. J. Natl. Cancer Inst. 83:346, 1991.

13. Alexander, R.B. and Rosenberg, S.A. Adoptively transferred tumor infiltrating lymphocytes can cure established metastatic tumor in mice and persist long term in vivo as functional memory T lymphocytes. J. Immunother. 10:389-397, 1991.

14. Alexander, R.B., Bolton, E.S., Koenig, S., Jones, G.M., Topalian, S.L., June, C.H. and Rosenberg, S.A. Detection of antigen-specific T lymphocytes by determination of intracellular calcium concentration using flow cytometry. J. Immunol. Methods 148:131-141, 1992.

15. Alexander, R.B., Walther, M.M., and Linehan, W.M. Immunotherapy of renal cell


carcinoma. Contemp. Urology. 4:13-25, 1992.16. Choyke, P.L., Glenn, G.M., Walther, M.M., Zbar, B., Weiss, G.M., Alexander, R.B., Hayes,

W.S., Long, J.P., Thakore, K.N., and Linehan, W.M. The natural history of renal lesions in von Hippel-Lindau disease: A serial CT study in 28 patients. Am. J. Roentgen. 159:1229-1234, 1992.

17. Alexander, R.B. Tumor necrosis factor and chemotherapeutic drugs targeted at DNA topoisomerase II for the treatment of genitourinary malignancies. Cancer Treat.Res. 59:105-120, 1992.

18. Linehan, W.M., Walther, M.M., Alexander, R.B., and Rosenberg, S.A. Adoptive immunotherapy of renal cell carcinoma: Studies from the Surgery Branch, National Cancer Institute. Sem. Urology 11:41-43, 1993.

19. Long, J.P., Walther, M.M., Alexander, R.B., Linehan, W.M., and Rosenberg, S.A. The management of isolated renal recurrence of renal cell carcinoma following complete response to interleukin-2 based immunotherapy. J. Urol. 150: 176-178, 1993.

20. Walther, M.M., Alexander, R.B., Weiss, G.M., Venzon, D., Berman, A., Pass, H.I., Linehan, W.M.,and Rosenberg, S.A. Cytoreductive surgery prior to interleukin-2 based therapy in patients with metastatic renal cell carcinoma. Urology 42:250-257, 1993.

21. Wallace, P.K., Palmer, L.D., Perry-Lalley, D., Bolton, E.S., Alexander, R.B., Horan, P.K., Yang, J.C. and Muirhead, K.A. Mechanisms of adoptive immunotherapy: Improved methods for in vivo tracking of tumor infiltrating lymphocytes and lymphokine activated killer cells. Cancer Res. 53:2358-2367, 1993.

22. Marcus, S.G., Choyke, P.L., Reiter, R., Linehan, W.M., Jaffe, G.S., Alexander, R.B., Rosenberg, S.A. and Walther, M.M. Regression of metastatic renal cell carcinoma after cytoreductive nephrectomy. J. Urol. 150: 463-466, 1993.

23. Cohen, P.A., Kim, H., Fowler, D.H., Gress, R.E., Jakobsen, M.K., Alexander, R.B., Mulé, J.J., Carter, C. and Rosenberg, S.A. Use of interleukin-7, interleukin-2 and interferon- to propagate CD4+ T cells in culture with maintained antigen specificity. J. Immunother. 14:242-252, 1993.

24. Alexander, R.B., Thompson, N., Pockaj, B.A. and Chang, R. Dilation of lower ureteral strictures with van Andel catheters. J. Urol. 152:68-69, 1994.

25. Marincola, F.M., Shamamian, P., Alexander, R.B., Gnarra, J.R., Turetskaya, R.L., Nedospasov, S.A., Simonis, T.B., Tauenberger, J.K., Yannelli, J., Mixon, A., Restifo, N.P., Herlyn, M., and Rosenberg, S.A. Loss of HLA haplotype and B locus down-regulation in melanoma cell lines. J Immunol 153:1225-1237, 1994.

26. Walther, M.M., Choyke, P.L., Hayes, W., Shawker, T.H., Alexander, R.B. and Linehan, W.M. Evaluation of color doppler intraoperative ultrasound in parenchymal sparing renal surgery. J Urol. 152:1984-1987, 1994.

27. Alexander, R.B., Fitzgerald, E.B., Mixon, A., Carter, C.S., Jakobsen, M., Cohen, P.A., and Rosenberg, S.A. Helper T cells infiltrating human renal cell carcinomas have the phenotype of activated memory-like T lymphocytes. J. Immunother. 17:39-46, 1995.

28. Walther, M.M., Choyke, P.L., Weiss, G, Manolatos. C., Long, J., Reiter, R., Alexander, R.B., and Linehan, W.M. Parenchymal sparing surgery in patients with hereditary renal cell carcinoma. J Urol 153:913-916, 1995.


29. Jakobsen, M.K., Restifo, N.P., Cohen, P.A., Marincola, F.M., Cheshire, L.B., Linehan, W.M., Rosenberg, S.A. and Alexander, R.B. Defective MHC class I expression in a sarcomatoid renal cell carinoma cell line. J Immunother 17:222-228, 1995.

30. Alexander, R.B. and Trissel, D. Chronic prostatitis: Results of an Internet survey. Urology 48:568-574, 1996.

31. Walther, M.M., Jennings, S.B., Choyke, P.L., Andrich, M., Hurley, K., Linehan, W.M., Rosenberg, S.A. and Alexander, R.B. Isolated perfusion of the kidney with tumor necrosis factor for localized renal cell carcinoma. World J Urol;14 Suppl 1:S2-7, 1996.

32. Friedman, E.J., Orth, C.R., Brewton, K.A., Ponniah, S. and Alexander, R.B. Cryosurgical ablation of the normal ventral prostate plus adjuvant does not protect Copenhagen rats from Dunning prostatic adenocarcinoma challenge. J Urology 158:1585-1588, 1997.

33. Alexander, R.B., Brady, F. and Ponniah, S. Autoimmune prostatitis: Evidence of T cell reactivity with normal prostatic proteins. Urology 50:893-899, 1997.

34. Alexander, R.B., Brady, F., Leffell, M.S., Tsai, V. and Celis, E. Specific T cell recognition of peptides derived from prostate-specific antigen in patients with prostate cancer. Urology 51:150-157, 1998.

35. Kyprianou, N., Litvak, J.P., Borkowski, A., Alexander, R.B., and Jacobs, S.C. Induction of apoptosis by doxazosin in benign prostatic hyperplasia. J Urology 159:1810-1815, 1998.

36. Keay, S., Zhang, C.-O,. Baldwin, B.R., Alexander, R.B. and Warren, J. Polymerase chain reaction amplification of bacterial 16s rRNA genes from cold cup biopsy forceps. J. Urology 160:2229-2231, 1998.

37. Alexander, R.B., Ponniah, S., Hasday, J. and Hebel, J.R. Elevated levels of pro-inflammatory cytokines in the semen of patients with chronic prostatitis/chronic pelvic pain syndrome. Urology 52:744-749, 1998.

38. Keay, S., Zhang, C.-O., Baldwin, B.R. and. Alexander, R.B. Polymerase chain reaction amplification of bacterial 16s rRNA genes in prostate biopsies from men without chronic prostatitis. Urology 53:487-491, 1999.

39. Nickel, J.C., Alexander, R.B., Anderson, R., Krieger, J., Moon, T., Neal, D., Schaeffer, A. and Shoskes, D. Prostatitis unplugged? Prostatic massage revisited. Techniques in Urology 5:1-7, 1999.

40. Litwin, M.S., McNaughton-Collins, M., Fowler, F.J., Nickel, J.C., Calhoun, E.A., Pontari, M.A., Alexander, R.B., Farrar, J.T., O’Leary, M.P. and the Chronic Prostatitis Collaborative Research Network. The National Institutes of Health Chronic Prostatitis Symptom Index: Development and validation of a new outcome measure. J. Urology 162:369-375, 1999.

41. Berlyn, K.A., Ponniah, S., Stass, S.A., Malone, J.G., Hamlin-Green, G., Lim, J.K., Fox, M., Tricot, G., Alexander, R.B., Mann, D.L., and Malone, R.W. Developing dendritic cell polynucleotide vaccination for prostate cancer immunotherapy. J Biotechnol 73:155-79, 1999.

42. Ponniah, S., Arah, I. and Alexander, R.B. PSA is a candidate self-antigen in autoimmune chronic prostatitis/chronic pelvic pain syndrome. Prostate 44:49-54, 2000.

43. Berlyn, K.A., Schultes, B., Leveugle, B., Noujaim, A.A., Alexander, R.B., and Mann, D.L. Generation of CD4+ and CD8+ T lymphocyte responses by dendritic cells armed with PSA/anti-PSA (antigen:antibody) complexes. Clin Immunol 101:276-283, 2001.


44. Dibiase, S.J., Hosseinzadeh, K., Gullapalli, R.P., Jacobs, S.C., Naslund, M.J. Sklar, G.N. Alexander, R.B., andYu, C. Magnetic resonance spectroscopic imaging-guided brachytherapy for localized prostate cancer. Int. J. Radiation Oncology Biol Phys 52:429-438, 2002.

45. Propert, K.J., Alexander, R.B., Nickel, J.C., Kusek, J.W., Litwin, M.S., Landis, J.R., Nyberg, L.M., Schaeffer, A.J. and the Chronic Prostatitis Collaborative Research Network (CPCRN). The design of a multi-center randomized clinical trial for chronic prostatitis/chronic pelvic pain syndrome. Urology 59:870-876, 2002.

46. Schaeffer, A.J., Landis, J.R., Knauss, J.S., Propert, K.J., Mazurick, C.A., Nickel, J.C., Shoskes, D.A., Alexander, R.B., Litwin, M.S., Nickel, J.C., O’Leary, M.P., Nadler, R.B., Pontari, M.A., Shoskes, D.A., Zeitlin, S.I., Fowler, Jr., J.E., Mazurick, C.A., Kishel, L., Kusek, J.W. and Nyberg, L.M. Demographic and clinical characteristics of men with chronic prostatitis: The National Institutes of Health Chronic Prostatitis Cohort Study. J Urology 168:593-598, 2002.

47. Schaeffer, A.J., Knauss, J.S., Landis, J.R., Propert, K.J., Alexander, R.B., Litwin, M.S., Nickel, J.C., O’Leary, M.P., Nadler, R.B., Pontari, M.A., Shoskes, D.A., Zeitlin, S.I., Fowler, Jr., J.E., Mazurick, C.A., Kusek, J.W. and Nyberg, L.M. Leukocyte and bacterial counts do not correlate with severity of symptoms in men with chronic prostatitis: The National Institutes of Health Chronic Prostatitis Cohort Study. J Urology 168:1048-1053, 2002.

48. Nickel, J.C.; Alexander, R.B.; Schaeffer, A.J.; Landis, J.R.; Knauss, J.S.; Propert, K.J. Leukocytes and bacteria in men with chronic prostatitis/chronic pelvic pain syndrome compared to asymptomatic controls. J Urology 170:818-822, 2003.

49. Alexander, R.B., Radical prostatectomy for chronic prostatitis: BJU International, 91 (3cr), 300, 2003.

50. Klyushnenkova, E. N., Ponniah, S., Rodriguez, A., Kodak, J., Mann, D. L., Langerman, A., Nishimura, M.I. and Alexander, R.B., CD4 and CD8 T lymphocyte recognition of prostate specific antigen in a patient with granulomatous prostatitis. J Immunotherapy 27:136-146, 2004.

51. Keay, S., Zhang, C.-O., Chai, T., Warren, J. Koch, K., Grkovic, D., Colville, H., and Alexander, R.B. Antiproliferative Factor, Heparin-Binding Epidermal Growth Factor-Like Growth Factor, and Epidermal Growth Factor in Men with Interstitial Cystitis vs. Chronic Pelvic Pain Syndrome. Urology 63:22-26, 2004.

52. Alexander, R.B., Mann, D.L., Borkowski, A.A., Fernandez-Vina, M., Klyushnenkova, E.N., Kodak, J., Propert, K.J. and Kincaid, M. Granulomatous prostatitis linked to HLA-DRB1*1501. J Urology 171:2326-2329, 2004.

53. Alexander, R.B., Propert, K.J., Schaeffer, A.J., Landis, J.R., Nickel, J.C., O'Leary, M.P., Pontari, M.A., McNaughton-Collins, M., Shoskes, D.A., Comiter, C.V., Datta, N.S., Fowler, Jr., J.E., Nadler, R.B., Zeitlin, S.I., Knauss, J.S., Kusek, J.W., Nyberg, L.M., and Litwin, M.S. A Randomized Trial of Ciprofloxacin and Tamsulosin in Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome. Ann Intern Med 141:581-589, 2004.

54. Alexander, R.B., Treatment of Chronic Prostatitis. Nature Clin Practice Urol, 1:2-3, 2004.55. Klyushnenkova, E.N., Link, J., Oberle, W.T., Kodak, J., Rich , C., Vandenbark, A.A., and

Alexander, R.B. Identification of HLA-DRB1*1501-restricted T cell epitopes from Prostate Specific Antigen, Clin Cancer Research 11:2853-2861, 2005.


56. .Nadler, R.B., McNaughton-Collins, M., Propert, K.J., Mikolajczyk, S.D., Knauss, J.S., Landis, J.R., Fowler, Jr., J.E., Schaeffer, A.J., and Alexander, R.B. Prostate-specific antigen test in diagnostic evaluation of chronic prostatitis/chronic pelvic pain syndrome, Urology 67:337-342, 2006.

57. Propert, K.J., Litwin, M.S., Wang, Y., Alexander, R.B., Calhoun, E., Nickel, J.C., O’Leary, M.P., Pontari, M., McNaughton-Collins, M. Responsiveness of the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI). Quality Life Res; 15:299-305, 2006.

58. Kodak, J.A., Mann, D.L., Klyushnenkova, E.N., Alexander, R.B. Activation of innate immunity by prostate specific antigen (PSA). Prostate, in press 2006.

59. Nickel, J.C., Shoskes, D., Wang, Y., Alexander, R.B., Fowler, Jr., J.E., Zeitlin, S., O’Leary, M.P., Pontari, M.A., Schaeffer, A.J., Landis, J.R., Nyberg, L., Kusek, J.W. and Propert, K.J. How does the pre- and post- massage test (PPMT) 2-glass test compare to the Meares-Stamey 4-glass test in men with chronic prostatitis/chronic pelvic pain syndrome? 2005. Submitted.

Other brief communications1. Alexander, R.B. Book review “Tumor Necrosis Factor: Structure, Mechanism of Action,

Role in Disease and Therapy.” J. Natl. Cancer Inst. 82:1506, 1990.2. Alexander, R.B. and Linehan, W.M. Editorial comment re: Tsukamoto T., et. al, Interleukin-

6 in renal cell carcinoma, J. Urology 148:1778-1782, 1992, J. Urology 148:1781, 1992.3. Alexander, R.B. Immunotherapy in genito-urinary malignancies. in Objectives for Urology

Residency Education, edited by M. Resnick, Society of University Urologists, 1993, pp. 133-134.

4. Alexander, R.B. and Linehan, W.M. Editorial comment re: Belldegrun, A., et. al., Interferon alpha-primed tumor infiltrating lymphocytes combined with interleukin-2 and interferon alpha as a therapy for metastatic renal cell carcinoma, J Urology 150:1384-1390, 1993, J Urology 150:1390, 1993.

5. Alexander, R.B. Commentary on immunotherapy, gene therapy and cancer. “This month in investigative urology” editorial, J . Urology 153:300, 1995.

6. Alexander, R.B. Letter to the editor re: Xue BH, Zhang Y, Sosman JA, Peace DJ: Induction of human cytotoxic T lymphocytes specific for prostate-specific antigen. Prostate 30:73-78, 1997, Prostate 32:73, 1997.

7. Alexander, R.B. CD8 based T cell vaccination and CD4 T cell responses in prostate cancer. Invited commentary on: Harada, M, Matsueda, S, Yao, A, Noguchi, M and Itoh, K. Vaccination of cytotoxic T lymphocyte directed peptides elicited and spread humoral and Th1-type immune responses to prostate specific antigen in a prostate cancer patient. J. Imunother 28:295-6, 2005.

Selected Abstracts1. Beer, M., Wiggins, J., Alexander, R.B., Schettino, R., Stockert, C. and Piez, K. Electron

microscopy of selectively stained collagen. Electron Microscopy Society of America, 1979.2. Alexander, R.B., Greene, G.L. and Barrack, E.R. Estrogen receptor binding to nuclear matrix

of estrogen target tissue: Direct demonstration using monoclonal antibody. American Urological Association, 1985.


3. Alexander, R.B., Isaacs, J.T. and Coffey, D.S. Tumor necrosis factor and chemotherapeutic drugs targeted at DNA topoisomerase II: A synergistically effective treatment for murine bladder cancer in vitro and in vivo. American Urological Association, 1987.

4. Alexander, R.B., Nelson, W.G. and Coffey, D.S. Tumor necrosis factor enhances the cytotoxicity of chemotherapeutic drugs targeted at DNA topoisomerase II. American Association for Cancer Research, 1987.

5. Alexander, R.B., Maguire, M.G., Epstein, J.I. and Walsh, P.C. Pathologic stage is higher in older men with clinical stage B1 adenocarcinoma of the prostate. American Urological Association, 1988.

6. Alexander, R.B. and Rosenberg, S.A. Long term survival of tumor infiltrating lymphocytes (TIL) in normal mice. Society for Biologic Therapy, 1989.

7. Alexander, R.B. and Rosenberg, S.A. Adoptively transferred tumor infiltrating lymphocytes persist long term in vivo as functional memory T cells. American Association for Cancer Research, 1990.

8. Walther, M.M., Weiss, G.H., Spencer, W., Alexander, R.B., and Linehan, W.M. Cytoreductive surgery in patients with metastatic renal cell carcinoma prior to IL- 2 based immunotherapy. American Urological Association, 1991.

9. Alexander, R.B., Lange, J.R., Pockaj, B.A., Long, J.P., Chang, R., and Linehan, W.M. Dilation of ureteral strictures with Van Andel catheters. Mid Atlantic section of American Urological Association, 1991.

10. Stetler-Stevenson, M., Solomon, D., Sebers, S., King, C., Linehan, W.M., Alexander, R.B., and Walther, M.M. DNA content analysis of bladder washings in patients undergoing ureteral stent changes. United States and Canadian Academy of Pathology, 1991.

11. Bolton, E.S., Rosenberg, S.A., and Alexander, R.B. Detection of Tumor Specific T Lymphocytes by Determination of Intracellular Calcium Concentration and Conjugate Formation. New York Academy of Sciences Clinical Conference on Flow Cytometry, 1992.

12. Alexander, R.B., Bolton, E.S., Pockaj, B.A., Linehan, W.M. and Rosenberg, S.A. Detection of individual T cell antitumor reactivity in tumor infiltrating lymphocytes cultures. American Urological Association, 1992.

13. Glenn, G., Choyke, P., Walther, M.M., Alexander, R.B., Latif, F., Gnarra, J., Chew, E.,Oldfield, E., Manolatos, C., Lerman, M., Zbar, B. and Linehan, W.M. Screening for hereditary genitourinary malignancy: NCI experience. American Urological Association, 1992.

14. Cohen, P.A., Alexander, R.B., Shiloni, E.S., Rosenberg, S.A. and Mulé. Use of dendritic cells and interleukin-7 to propagate anti-tumor murine CD4+ T cells for subsequent adoptive therapy. Society for Biologic Therapy, 1992.

15. Jakobsen, M.K., Restifo, N.P., Cohen, P.A., Marincola, F.M., Linehan, W.M., Rosenberg, S.A., Alexander, R.B. Defective MHC class I expression in a sarcomatoid renal cell carcinoma cell line. American Urological Association, 1993.

16. Linehan, W.M., Glenn, G., Choyke, P., Walther, M.M., Alexander, R.B., Gnarra, J.R., Latif, F., Hurley, K., Manolatos, C., Lerman, M., and Zbar, B. Studies of familial renal cell carcinoma. American Urological Association, 1993.

17. Alexander, R.B., Fitzgerald, E.B., Jakobsen, M., Cohen, P.A., and Rosenberg, S.A. Helper T


cells infiltrating human renal cell carcinomas are activated, memory-like T cells. American Urological Association, 1994.

18. Alexander, R.B., Jennings, S., Walther, M.M., Terrill, R.E., McKinney, B.A., Witt, C., Choyke, P.L., Burris, J.A. and Rosenberg, S.A. Isolated perfusion of the kidney with tumor necrosis factor: preclinical study in miniature swine. Mid-Atlantic Section, American Urological Association, 1994.

19. Alexander, R.B., Jennings, S., Walther, M.M., Terrill, R.E., McKinney, B.A., Witt, C., Choyke, P.L., Burris, J.A. and Rosenberg, S.A. Isolated perfusion of the kidney with tumor necrosis factor: preclinical study in miniature swine. American Urological Association, 1995.

20. Alexander, R.B., Brady, F., Leffell, M.S., Tsai, V. and Celis, E. Specific recognition of peptides derived from prostate specific antigen (PSA) by peripheral blood lymphocytes from HLA-A2 patients with prostatic cancer. Mid-Atlantic Section, American Urological Association, 1995 .

21. Friedman, E.J., Orth, C.R., Brewton, K.A., Ponniah, S. and Alexander, R.B. Cryosurgery enhances Dunning tumor growth in Copenhagen rats. Mid-Atlantic Section, American Urological Association, 1996.

22. Alexander, R.B. Brady, F. and Ponniah, S. Autoimmune prostatitis: evidence of T cell reactivity with normal prostatic proteins in men with a history of prostatitis. American Urological Association, 1997.

23. Ponniah, S. and Alexander, R.B. Detection of CD4 T cell immune response against purified prostatic proteins in a patient with chronic non bacterial prostatitis using in vitro cultured dendritic cells as antigen presenting cells.2nd World Congress on Urological Research, 1997.

24. Kyprianou, N., Litvak, J. Alexander, R.B., Borkowski, A and Jacobs, S.C. Induction of prostate apoptosis by doxazocin in BPH. 2nd World Congress on Urological Research, 1997.

25. Alexander, R.B., Arah, I. and Ponniah, S., Elevated proinflammatory cytokine levels in the semen of men with chronic prostatitis/chronic pelvic pain syndrome. Society for Basic Urological Research, Prouts Neck, ME, 10/1998.

26. Keay, S., Zhang, C,. Baldwin, B.R. and. Alexander, R.B. Bacterial DNA sequences in the prostate of men without chronic prostatitis. American Urological Association, 1998.

27. Litwin, M.S., McNaughton-Collins, M., Fowler, F.J., Nickel, J.C., Calhoun, E.A., Pontari, M.A., Alexander, R.B., Farrar, J.T., O’Leary, M.P. and the Chronic Prostatitis Collaborative Research Network. The National Institutes of Health Chronic Prostatitis Symptom Index: Development and validation of a new outcome measure. American Urological Association, 1999.

28. Alexander, R.B., Ponniah, S., Hasday J., and Arah, I, Elevated levels of pro-inflammatory cytokines in the semen of men with chronic prostatitis. American Urological Association, 1999.

29. Klyushnenkova, E.N., Ponniah, S., Rodriguez, A., Kodak, J., Mann, D. L. and Alexander, R.B. Generation of human CD4 and CD8 T lymphocyte lines that recognize prostate specific antigen (PSA) from peripheral blood of a patient with granulomatous prostatitis. Society for Basic Urological Research, 2000.

30. Ponniah, S. Rodriguez, A., Arah, I., Klyushnenkova, E., Kodak, J. and Alexander, R.B. A novel approach for the identification of prostate and tumor specific antigens in prostate


cancer. American Urological Association, 2000.31. Klyushnenkova, E.N., Ponniah, S., Mann, D.L., and Alexander, R.B. Generation of prostate

specific antigen (PSA)-reactive T cell lines - implications for prostate cancer immunotherapy American Association of Immunologists, 2000.

32. Schaeffer, A.J., Landis, A.R., Mazurick, C., Nickel, J.C., Shoskes, D., Alexander, R.B., Zeitlin, S., Propert, K.J., Santanna, J., Kishel, L.,. Kusek, J.W., Nyberg L.M., and the CPCRN Study Group. Inflammation and Infection Do Not Correlate with Severity of Symptoms in Men with Chronic Prostatitis: The NIH Chronic Prostatitis Cohort (CPC) Study. American Urological Association, 2001.

33. Nickel, J.C., Alexander, R.B., Schaeffer, A.J., Landis, J.R., Knauss, J., and Propert, K.J. Leukocyte and bacteria localization comparisons in men with chronic prostatitis and asymptomatic men: A case-control study. American Urological Association, 2002.

34. Alexander, R.B., Mann, D.L., Borkowski, A.A., Fernandez-Vina, M., and Kincaid, M. Granulomatous prostatitis linked to HLA-DR15. Mid Atlantic Section, American Urological Association, 2002.

35. Collins, M.M., Knauss, J.S., Propert, K.J., Landis, J.R., Mikolajczyk, S.D., Alexander, R.B., Fowler, Jr., J.E., Schaeffer, A.J., and the Chronic Prostatitis Collaborative Research Network (CPCRN), The prostate specific antigen (PSA) test is not helpful in the diagnostic evaluation of chronic prostatitis/chronic pelvic pain syndrome. American Urological Association, 2003.

36. Alexander, R.B., Mann, D.L., Borkowski, A.A., Fernandez-Vina, M., and Kincaid, M. Granulomatous prostatitis linked to HLA-DR15. American Urological Association, 2003.

37. Alexander, R.B., Propert, K.J., Schaeffer, A.J., Landis, J.R., Nickel, J.C., O'Leary, M.P., Pontari, M.A., McNaughton-Collins, M., Shoskes, D.A., Comiter, C.V., Datta, N.S., Fowler, Jr., J.E., Nadler, R.B., Zeitlin, S.I., Knauss, J.S., Kusek, J.W., Nyberg, L.M., and Litwin, M.S. A randomized clinical trial of ciprofloxacin and tamsulosin for chronic prostatitis/chronic pelvic pain syndrome, American Urological Association, 2004.

38. Oberle. W.T., Klyushnenkova, E.N. and Alexander, R.B. T lymphocyte recognition of PSA-3A peptide in men with autoimmune prostatitis. Mid Atlantic Section, American Urological Association, 2004.

39. Klyushnenkova, E.N., Link, J., Oberle, W.T., Kodak, J., Rich , C., Vandenbark, A.A., and Alexander, R.B. Identification of HLA-DRB1*1501-restricted T cell epitopes from Prostate Specific Antigen, International Society for the Biologic Therapy of Cancer Annual Meeting, San Francisco, CA, 2004.

40. Oberle. W.T., Klyushnenkova, E.N. Mann, D. and Alexander, R.B. T lymphocyte recognition of PSA-3A peptide in men with autoimmune prostatitis. American Urological Association, San Antonio, TX, 2005.

Major Invited Speeches1. Alexander, R.B., Prostate I: Biology and clinical background. Armed Forces Institute of

Pathology Uroradiology Course, Washington, DC, 4/1992.2. Alexander, R.B., Immunotherapy of Advanced Renal Cell Carcinoma. Xth Congress of

European Urology, Genova, Italy. 7/1992.3. Alexander, R.B., Simultaneous detection of T cell activation and T cell-antigen presenting


cell conjugates by flow cytometry. BDIS Capital Area Flow Cytometry Users Group meeting, Bethesda, MD, 6/1993.

4. Alexander, R.B., Adoptive Immunotherapy: Clinical Research. American Urological Association research conference “Immunology and Inflammation,” Houston, TX, 8/1993.

5. Alexander, R.B., Update on systemic IL-2 for renal cell carcinoma. American Urological Association Annual Meeting Evening Seminar, Renal Cell Carcinoma: Trends in Management of Advanced Disease, San Francisco, CA, 5/14/1994.

6. Alexander, R.B., Immunotherapy of renal cell carcinoma. Urology Grand Rounds, George Washington University Medical Center, Washington, DC, 9/28/1994.

7. Alexander, R.B., Immunotherapy of renal cell carcinoma. Urology Grand Rounds, Washington Hospital Center, Washington, DC, 10/25/1994.

8. Alexander, R.B., Immunotherapy of renal cell carcinoma. Seminars in Oncology, Howard University Cancer Center, Washington, DC, 10/27/1994.

9. Alexander, R.B., Immunotherapy of renal cell carcinoma. Urology Grand Rounds, Thomas Jefferson University, Jefferson Medical College, Philadelphia, PA, 11/30/1994.

10. Alexander, R.B., Immunotherapy of renal cell carcinoma. Urology Grand Rounds, Robert Wood Johnson University Hospital, New Brunswick, NJ, 12/1/1994.

11. Alexander, R.B., Immunotherapy of renal cell carcinoma. Urology Grand Rounds, Medical College of Virginia, Richmond, VA, 1/27/1995.

12. Alexander, R.B., Immunologic considerations in prostatic cancer. Second International Conference of Early Prostate Cancer, Budapest, Hungary, 6/4/1995.

13. Alexander, R.B., Immunotherapy of renal cell carcinoma. Tumor Board Conference, Brooklyn VA Medical Center, Brooklyn, NY. 9/27/1995.

14. Alexander, R.B., Immunotherapy of renal cell carcinoma. Urology Tumor Board Conference, Lehigh Valley Hospital Morgan Cancer Center, Allentown, PA 11/28/1995.

15. Alexander, R.B., Immunotherapy of renal cell carcinoma. Urology Grand Rounds, Temple University School of Medicine, Philadelphia, PA, 3/11/1996.

16. Alexander, R.B., Immunotherapy of renal cell carcinoma. Cancer Research Conference, Albany VA Medical Center, Albany, NY, 9/12/1996.

17. Alexander, R. B., Immunotherapy of renal cell carcinoma. Urology Grand Rounds, West Virginia University School of Medicine, Morgantown, WV, 11/8/1996.

18. Alexander, R. B., Immunotherapy of renal cell carcinoma. Urology Visiting Professor, SUNY Health Science Center, Syracuse, NY, 12/12/1996.

19. Alexander, R. B., Immunotherapy of renal cell carcinoma. Oncology Grand Rounds, University of Rochester Cancer Center, Rochester, NY, 1/30/1997.

20. Alexander, R. B., Immunotherapy of renal cell carcinoma. Medical Grand Rounds, East Orange VA Medical Center, East Orange, NJ, 6/4/1997.

21. Alexander, R. B., Immunotherapy of renal cell carcinoma. Urology Grand Rounds, Emory University, Atlanta, GA, 6/10/1997.

22. Alexander, R. B., Immunotherapy of renal cell carcinoma. Pennsylvania Oncologic Society/Pennsylvania Society of Hematology and Oncology Joint Scientific Meeting, York, PA, 9/27/1997.


23. Alexander, R. B., Immunotherapy of renal cell carcinoma. Washington VA Medical Center Medical Oncology Grand Rounds, Washington, DC, 11/3/1997.

24. Alexander, R. B., Immunotherapy of renal cell carcinoma. Greater Miami Urological Association Annual Meeting, Miami, FL, 12/4/1997.

25. Alexander, R. B. ,Immunotherapy of renal cell carcinoma. Atlanta Urological Society, Atlanta, GA, 2/17/1998.

26. Alexander, R.B., Visiting Professor, Washington Urological Association Annual Residents Day, Washington, DC, 2/21/1998.

27. Alexander, R. B., Prostatitis. Third Annual American Prostate Society Meeting, Baltimore, MD, 3/28/1998.

28. Alexander, R. B., Chronic Prostatitis. James Buchanan Brady Urological Institute Grand Rounds, Johns Hopkins Hospital, Baltimore, MD, 9/22/1998.

29. Alexander, R. B., Chronic Prostatitis. University of Pennsylvania Department of Urology Grand Rounds, Philadelphia PA, 9/24/1998.

30. Alexander, R. B., Immunotherapy of renal cell carcinoma. Urology Grand Rounds, State University of New York, Stony Brook, NY, 5/21/1999.

31. Alexander, R. B.,Chronic Prostatitis. New York Hospital/Cornell University Department of Urology Grand Rounds, 9/30/1999.

32. Alexander, R. B.,PSA is a candidate self antigen in auto-immune chronic prostatitis/chronic pelvic pain syndrome, Department of Urology, Johns Hopkins Hospital, Celebration of the Contribution of Donald S Coffey, Baltimore, MD, 10/1999.

33. Alexander, R. B., Chronic Prostatitis. American Prostate Society Annual Meeting, Baltimore, MD. 11/9/1999.

34. Alexander, R. B., Chronic Prostatitis. Philadelphia Urologic Society Annual Meeting, Philadelphia, PA, 11/18/1999.

35. Alexander, R.B., Update on Chronic Prostatitis, Cleveland Urological Association, Cleveland, OH, 11-16-2000.

36. Alexander, R.B., Update on Chronic Prostatitis, Pittsburgh Urological Association, Pittsburgh, PA, 2/19/2001.

37. Alexander, R.B., New Insights in Chronic Prostatitis, Maryland Urological Association, Baltimore, MD, 3/17/2001.

38. Alexander, R.B., Update on Chronic Prostatitis, 5th Annual Men’s Health Conference, 2001, Johns Hopkins University School of Medicine, Baltimore, MD, 3/23/2001.

39. Alexander, R.B., Update on Chronic Prostatitis, Division of Urology Grand Rounds, University of Maryland, Baltimore, MD, 4/19/2001.

40. Alexander, R.B., Use on interleukin-2 for renal cell carcinoma, Oncology Grand Rounds, University of Maryland Cancer Center, Baltimore, MD, 5/21/2001.

41. Alexander, R.B., Specific T lymphocyte recognition of PSA in granulomatous prostatitis, Johns Hopkins Medical and Surgical Association Biennial meeting, Brady Urological Institute, Baltimore, MD, 6/8/2001.

42. Alexander, R.B., Specific T lymphocyte recognition of PSA in granulomatous prostatitis, Invited Seminar, Surgery Branch, National Cancer Institute, Bethesda, MD, 6/20/2001.


43. Alexander, R.B., Update on BPH and Chronic Prostatitis, Pennsylvania Urological Association Annual meeting, Baltimore, MD, 6/24/2001.

44. Alexander, R.B., Inflammatory Disorders: Chronic Prostatitis, American Urological Association Summer Research Conference: Molecular Therapies, Houston, TX, 8/10/2001.

45. Alexander, R.B., Chronic Prostatitis: New Insights into an Old Disease, Society for Basic Urological Research, Phoenix, AZ, 12/2/2001.

46. Alexander, R.B., Chronic Prostatitis: New Insights into an Old Disease, Richmond Urological Association, Richmond, VA, 12/15/2001.

47. Alexander, R.B., Chronic Prostatitis: New Insights into an Old Disease, Washington Urological Association, Washington, DC, 1/17/2002.

48. Alexander, R.B., Medical therapy of BPH, Annapolis Urological Association meeting, Annapolis, MD, 4/4/2002.

49. Alexander, R.B., Chronic Prostatitis: New Insights into an Old Disease, Society for the Study of Male Reproduction, Orlando FL, 5/25/2002

50. Alexander, R.B., The Problem Prostate, Annual Primary Care Review Course, SUNY Stony Brook School of Medicine, Stony Brook, NY, 6/2/2002.

51. Alexander, R.B., Medical therapy of BPH, University of South Florida Division of Urology Rounds, Tampa, FL, 8/20/2002.

52. Alexander, R.B., Long term evidence-based management of BPH, Dartmouth-Hitchcock Primary Care Rounds, Hanover, NH, 10/2/2002.

53. Alexander, R.B., Long term evidence-based management of BPH, Brown Medical School/Rhode Island Hospital Division of Urology Grand Rounds, Providence, RI, 10/25/2002.

54. Alexander, R.B., Long term evidence-based management of BPH, University of Rochester Urology Grand Rounds, Rochester, NY, 1/21/2003.

55. Alexander, R.B., Long term evidence-based management of BPH, Wilmington Urological Association, Wilmington, DE, 2/20/2003.

56. Alexander, R.B., Prostatitis-Update on the CPCRN project, Maryland Urological Association, Baltimore, MD, 3/15/2003.

57. Alexander, R.B., Long term evidence-based management of BPH, Albany Urological, Albany, NY, 4/10/2003.

58. Alexander, R.B., Infection and Inflammation Review, Plenary session American Urological Association Annual Meeting, Chicago, IL, 4/28/2003.

59. Alexander, R.B., Long term evidence-based management of BPH, Pittsburgh Urological Association, Pittsburgh, PA, 5/14/2003.

60. Alexander, R.B., Presentation to U.S. House of Representatives Press Conference, “Training and Research in Urology Act” house bill in support of establishing a urology section at National Institute of Digestive, Diabetes and Kidney Diseases, on behalf of American Urological Asociation, 6/3/2003.

61. Alexander, R.B., Chronic Prostatitis: New Insights into an Old Disease, American Kidney Stone Management Annual Meeting, Orlando, FL, 8/8/2003.

62. Alexander, R.B., Chronic Prostatitis: New Insights, New York University Department of


Urology Annual Review Course, New York, NY, 12/11/2003.63. Alexander, R.B., Immunotherapy for prostate cancer, Prostate and Breast Cancer Group, UM

Greenebaum Cancer Center, Baltimore, MD, 2/2/2004.64. Alexander, R.B., Systemic Immunotherapy for Prostate Cancer, University of Maryland

Division of Urology Grand Rounds, Baltimore, MD, 3/11/2004.65. Alexander, R.B., Pelvic Pain Update, Society for Urodynamics and Female Urology Annual

Meeting, San Francisco, CA, 5/8/2004.66. Alexander, R.B., Advocacy at the Federal Government Level. Volunteering in Urology:

Young Urologists Forum, American Urological Association Annual Meeting, San Francisco, CA, 5/9/2004

67. Alexander, R.B., Minimally invasive therapies for BPH, Orlando Urological Society, Orlando, FL, 6/1/2004.

68. Alexander, R.B., Long term evidence-based management of BPH. Puerto Rico Urological Association Annual Meeting, San Juan, Puerto Rico, 7/24/2004.

69. Alexander, R.B., Long term evidence-based management of BPH. Butler VA Medical Center Primary Care Grand Rounds, Butler, PA, 10/26/2004.

70. Alexander, R.B., Update on Chronic Prostatitis. Lecture to University of Maryland Internal Medicine and Primary Care residents, University of Maryland School of Medicine, Baltimore, MD, 11/15/2004.

71. Alexander, R.B., Autoimmunity, prostatitis and immunotherapy for prostate cancer. Department of Urology, Johns Hopkins University School of Medicine “Brady Longrifles” meeting, Baltimore, MD, 1/12/2005.

72. Alexander, R.B., Evidence-based medical management of BPH in the VA. National broadcast lecture to VA Medical Centers, Albany VA Medical Center Medical Teaching Conference, Albany, NY, 1/27/2005.

73. Alexander, R.B., Update on Medical Therapy for BPH: The MTOPS Study. Lecture to University of Maryland Internal Medicine and Primary Care residents, University of Maryland School of Medicine, Baltimore, MD, 1/20/2005.

74. Alexander, R.B., Immunotherapy for prostate cancer. Maryland Urological Association, Baltimore, MD 3/6/2005.

75. Alexander, R.B., Update on Medical Therapy for BPH: The MTOPS Study. Medical Grand Rounds, VA Maryland Health Care System, Baltimore, MD, 5/6/2005.

76. Alexander, R.B., Biomarkers for Prostatitis. Society for Basic Urological Research, Annual Meeting, San Antonio, Texas, 5/21/2005.

77. Alexander, R.B., Update on Medical Therapy for BPH: The MTOPS Study. Medical Grand Rounds, VA Causeway clinic, Boston, MA, 6/2/2005.

78. Alexander, R.B., Origin, diagnosis and treatment of prostatitis, International Congress of Andrology, Seoul, Korea, 6/13/2005.

79. Alexander, R.B., Autoimmunity, prostatitis and immunotherapy for prostate cancer. Washington Hospital Center Department of Urology Grand Rounds, Washington, DC, 8/16/05.

80. Alexander, R.B., Clinical trials in prostatitis, AUA Summer Research Conference


“Inflammation in prostate diseases,” Baltimore, MD 8/19/05.81. Alexander, R.B., Update on Chronic Prostatitis, Grand Rounds, Department of Urology,

SUNY Syracuse, Syracuse NY, 10/6/05.82. Alexander, R.B., Update on Medical Therapy for BPH: The MTOPS Study. Medical Grand

Rounds, Brockton VA Brockton, MA, 10/12/05.83. Alexander, R.B., Autoimmunity in chronic prostatitis. Chronic Pelvic Pain/Chronic

Prostatitis Scientific Workshop, Sponsored by NIDDK, Baltimore, MD, 10-20-05.84. Alexander, R.B., Vaccination therapy for prostate cancer. Research Matters, a joint program

of University of Maryland and Johns Hopkins Cancer Centers, 11-17-05.85. Alexander, R.B., Update on Chronic Prostatitis, Grand Rounds, University of Maryland

Internal Medicine and Primary Care residents, University of Maryland School of Medicine, Baltimore, MD, 2/13/06

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