Dominic Paviour CV

Curriculum Vitae

Dr Dominic C. Paviour MBBS BSc PhD MRCP

January 2014

GMC 4546931

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Dominic Paviour CV

Contents

PersonalPersonal Details 3

Personal Statement 3

Qualifications 4

Medicolegal Experience 4

Clinical Expertise 4

Prizes and Grants 5

Employment HistoryCurrent Employment 6

Previous Employment 6

Clinical Experience 6

Clinical Governance 8

Management and Leadership 10

Teaching and Education 12

Research 13

Publications 15

Presentations 18

Courses and Meetings 19

References 23

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Dominic Paviour CV

Personal

Personal Details Full name: Dominic Curtis Paviour

Contact Address: ML Secretary: SM Legal Services, 71

Walsall Road, Birmingham, B74 3BA

Phone: 0121 352 0517

Email: mls@smlegalservices.co.uk

Date of birth: 31st December 1973

Marital status: Married

Nationality: British

Driving licence: Full

GMC registration: 4546931

Specialist Register: 14th September 2011

Indemnity: Medical Defence Union

Education: United Medical and Dental Schools of Guys and St Thomas’ Hospitals

(UMDS) 1992-1998

Personal Statement:

I am a consultant neurologist with a busy general neurology practice and a specialist interest

in movement disorders and neuro-degenerative disease. I see approximately 1200 new and

2000 follow up patients per annum. These patients have a broad range of acute and chronic

neurological problems.

I am committed to improving the quality and safety of patient care in the NHS through

innovation as well as effective management of existing resources, involving patients in their

care, audit and education. As I move into a more senior position I intend to maintain a

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Dominic Paviour CV

teaching commitment, become more involved with management, and in time Trust Committee

work.

Qualifications

Qualifications: BSc Neuroscience First class Honours – Univ. of London 1995

MBBS (Proxime Accessit to University of London Medal) 1998

MRCP (London) 2001

PhD Clinical Medicine, University College London 2006

Learned Bodies: Association of British Neurologists, American Academy of Neurology,

Movement Disorder Society, The Royal Society of Medicine

Professional Bodies: GMC (4546931), BMA, MDU

Medico-legal Experience

I am a provisional member of the Expert Witness Institute since December 2013.

I have been taking medico-legal instructions in the last year. My work so far has involved only

civil and one criminal case. Neither of these resulted in my needing to attend court to give

evidence.

I have completed the BMA course on acting as a medical expert witness and more recently have

completed a course on Civil proceedings and report writing run by ProSols (MEDICO-LEGAL

REPORT WRITING IN CIVIL CLAIMS (CORE SKILLS) and am up to date with the latest CPR

guidance and the Woolf reforms.

Clinical Expertise

Current EmploymentConsultant Neurologist Epsom and St Helier Hospital NHS Trust

Honorary Consultant Neurologist St George’s Hospital NHS Trust

Honorary Senior Lecturer St George’s Hospital Medical School Aug 2011– Current

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Dominic Paviour CV

General Neurology ExperienceI see approximately 1200 new and 2000 follow up patients per annum. These patients have a

broad range of acute and chronic neurological problems. The commonest neurological disorders

of adult life include headache, cerebrovascular disease (strokes and TIA), seizures and epilepsy,

disorders of balance and dizziness, disorders of movement including tremor, inflammatory,

infectious and degenerative disorders of the nervous system and I see patients with these

disorders every week.

Sub-specialist interestI am the clinical lead for the movement disorders service at St George’s Hospital NHS Trust in

South West London. I have a specialist interest in Parkinson’s disease and other degenerative

causes of Parkinsonism and the advanced medical treatment of these disorders.

Prizes and Grants

PrizesPostgraduate:One of three “Young Scientists Best Poster Award”: 10th International Conference on Parkinson’s Disease and Movement Disorders, Kyoto, Japan, October 2006. MRI Derived Rates of Brain Atrophy in PSP and MSA-P: Clinical Correlations and Required Sample Sizes to Detect Treatment Effects.

London Deanery “Leadership, teamwork and innovation within the changing face of the NHS” March 2011 – Best Poster Presentation – A Neurologist in the MAU? – Acute Neurology, a change in the patient pathway.

Undergraduate: Proxime Accessit to the University of London Medal 1998 UMDS Gold Medal and Prize 1998

Distinctions in Medicine, Surgery, Psychiatry, Paediatrics, Clinical Pharmacology, Pathology and Anatomy The Novartis Prize for Neurology 1998 The Hadden Memorial Prize 1998 The Mead Medal and Perkins Prize for Medicine 1998 The Treasurers Medal and Tewfick Prize for Surgery 1998 The Phillip Evans Prize for Paediatrics 1996 The Leonard Lubbock and Prunty Prize for Chemical Pathology 1996

Grants

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Dominic Paviour CV

PSP Europe Association grant – funding for PhD research project, awarded with Prof. A. Lees as principal investigator.

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Dominic Paviour CV

Employment History

Current EmploymentConsultant Neurologist Epsom and St Helier Hospital NHS Trust

Honorary Consultant Neurologist St George’s Hospital NHS Trust

Honorary Senior Lecturer St George’s Hospital Medical School Aug

2011– Current

Previous EmploymentWalport academic clinical lecturer and Neurology SpR

St George’s Hospital, and SGUL. Aug

2009- Aug 11

Neurology SpR London, Kent, Surrey and Sussex Deanery 2006-

2009

Kings College Hospital NHS Foundation Trust Feb

09-Aug 09

OOPE – GSK CIC Hammersmith Hospital Aug

08-Feb 09

Guy’s and St Thomas’ Hospital Foundation Trust Feb

08-Aug 09

Hurstwood Park Neurological Centre, BSUH NHS Trust Feb

07-Feb 08

Kings College Hospital NHS Trust Aug

06-Feb 07

Clinical Research Fellow, Institute of Neurology, UCL, London 2002-

2006

Neurology Senior House Officer, St Thomas’s Hospital, London 2001-

2002

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Dominic Paviour CV

Medical Senior House Officer, Oxford Radcliffe Hospitals 1999-

2001

Surgical House Officer, Greenwich Hospital, London 1999

Medical House Officer, St Thomas’s Hospital, London 1998-

1999

Clinical Experience

General NeurologyI have a broad general clinical neurology exerience. I looked after general neurology

in-patients and out-patients in a district general and regional neuroscience centre

setting. I see between 1500-2000 patients (mostly out-patients) per year. I see

patients across all neurological sub-specialties and in the past have worked in

specialist clinics for movement disorders, dementia, peripheral nerve and muscle,

headache, neuro-ophthalmology and epilepsy as well as looking after non-surgical

head-injured patients.

I keep up to date with “Good Clinical Practice” training, and I have recruited subjects

to medical and neurosurgical trials when appropriate (IST-3, STICH II and CADISS).

My portfolio and record of training together with regular appraisals and assessments

demonstrate high quality clinical neurology training.

Excellent feedback from work based assessments of my competency as a clinician

(CBD, MiniCEX and MSFs) and annual appraisals reflect my high standards of day-

to-day clinical practice.

I will provide a high standard of clinical input to neurology patients admitted to

general medical wards as well as those seen in outpatient clinics. I will contribute to

organisation and development of services and will help to develop common

neurology policies Trust-wide in conjunction with other physicians.

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Dominic Paviour CV

Specialist InterestI have a clinical research interest in neurodegenerative disease and in particular

movement disorders and spent 4 years at Queen Square completing a PhD thesis

related to structural MRI in degenerative Parkinsonian syndromes. During this period

I saw patients in a tertiary movement disorders clinics (2-3 clinics per week), as well

as a botulinum toxin clinic for dystonia (fortnightly clinic, ~500 patients injected over

4 years).

Neurodegenerative diseases are long-term conditions and are increasingly

recognised as having a wide phenotypic spectrum resulting in their presenting to

cognitive, movement disorder and specialist motor neuron disease services. I have

worked in a cognitive disorders service for a total of 9 months as well as in the motor

nerve clinic at Kings College Hospital for a total of 12 months during my training

period and so have extensive experience of these conditions and how to manage

them.

I have a broad experience in this specialist field of neurology and am capable of

managing patients with degenerative diseases in a multidisciplinary setting. I have

published extensively in this field of clinical neurology and would be well placed to

contribute to the continuation and development of a clinical service.

My broad experience of other neurological sub-specialties means I would be well

placed to assist in setting up other services if required.

Clinical Governance

Clinical Audit - I have completed a formal e-course on “Mastering clinical audit”

(University of Edinburgh, 2005), and have applied the skills acquired, to audits

throughout my medical career. I have conducted several clinical audits and I

understand how determining a theme for audit, setting standards of care, auditing

and then implementing change can improve safety, clinical effectiveness and aid

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Dominic Paviour CV

service development. I am currently auditing IVIg prescribing with a view to

streamlining prescribing and reducing cost.

Past audits include:

1. An audit of acute neurology referrals at a district general hospital (St

Helier) demonstrating that implementation of a new e-referral system

facilitated more timely input and a change in management in all cases.

2. An audit of my own practice reflecting parity with the rates of referral for

imaging in headache patients when referred to a neurology clinic.

3. An audit of admissions through the acute medical unit at St George’s

Hospital, identifying that 20% of adult admissions have a primary

neurological diagnosis. Excluding stroke and head injury (which have an

existing care pathway) means that only 40% of these have acute

neurological input. The results of this and the outcome of a subsequent

change in the treatment pathway were presented at the first London

school of Medicine and Medical specialties leadership & innovation

conference (March 2011) winning the “best poster” prize.

A review of the use of dopaminergic imaging in a specialist movement

disorders service at St George’s Hospital identifying that the majority of

requests were appropriate but that 10% were requested without a clear

indication and did not alter management. This data was presented at the

monthly departmental audit meeting (January 2011).

I have audited the use of a specialist investigation (sphincter EMG) in

degenerative movement disorders and the results have been peer

reviewed and published.

Clinical Effectiveness and service developmentI have implemented an e-referral system for acute in-patient referrals ensuring that

patients are seen in a timely fashion resulting in better care and a change in

management in the majority of cases.

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Dominic Paviour CV

I have mentored a new community Parkinson’s disease Nurse in the Sutton and

Merton region ensuring better care for patients with this progressive degenerative

disease.

I have secured a new MS Nurse specialist locally, one day a week after discussion

with the specialist nurses at St George’s which should mean that local patients do

not have to travel so far to obtain advice and a clinical review.

Based on the results of a separate audit of neurological admissions through the MAU

at St Georges, a prospective change (whereby patients could be added to two out-

patient clinics during the week as well as having access to urgent day-unit

investigations) was implemented. This resulted in a reduced length of stay as well as

an increase in day unit and out-patient activity over a 4 month period. This innovation

was good for the medical admissions unit as well as resulting in more planned

activity for the clinical neurology service. Most importantly however it resulted in a

“leaner” and higher quality patient pathway.

Evidence-based Medicine – I am aware of the different levels of clinical evidence

and review and update my clinical practice in light of emerging evidence on a regular

basis. The ability to critically appraise research studies is a key transferable skill from

my time spent in clinical research. I attend weekly journal clubs where papers that

may change our clinical practice are discussed. I attend weekly departmental

meetings as part of my on-going education and CPD.

Involving patients and the local community - I seek feedback from patients and

reflect on my practice based on their comments. I have also made stronger contacts

with the community teams in Sutton and Merton and attend meetings when I can.

Risk Management - Risk is inherent in clinical practice but managing it effectively

minimises the potential for poor patient outcomes in clinical practice. This can be

achieved by identifying near misses and incidents (which I have reported in the past)

and adapting practices to avoid problems in the future. Taking note of complaints,

which are a marker of potential adverse events is also critical.

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Dominic Paviour CV

I have written a departmental “guideline” for the management of acute presentations

of myasthenia gravis to the neurology unit, in order to minimise the risk of patients

being discharged without due consideration of appropriate immunosuppression.

Management and Leadership

I enjoy organisational responsibilities; I am a capable person and am effective in

motivating others to achieve set targets as well as managing my own workload.

My achievements include:

Clinical Lead for Movement Disorders – St George’s Hospital NHS Trust – CurrentDespite only being on site at St George’s for two days every week, I have led on the

addition of 8 drugs used in the management of Parkinson’s disease to the Hospital

formulary and written and circulated shared care protocols for primary care

colleagues related to the use of these products.

I have written a successful business plan for the funding of Apomorphine therapy in

Parkinson’s disease meaning the administration of this is much more transparent

and efficient at a predictable, planned and commissioned cost with home delivery of

therapy.

I have set up a monthly “advanced PD” clinic run jointly by myself and the PD Nurse

specialist, directed towards the assessment and appropriate selection of patients for

major therapeutic interventions in PD.

I mentor a local community PDNS, new in post in the last 18 months and have

lobbied successfully for another 0.5 time PDNS in the hospital to help cope with the

caseload of ~600 patients.

General Neurology – St Helier Hospital NHS Trust - Current

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Dominic Paviour CV

In the 2 years since my appointment as well as completing over 2500 out-patient

episodes with a high proportion of new:follow up (approx. 1.5:1), I have initiated a

new acute neurology electronic referral system, making the process of referral more

efficient and measurable.

I am in the final stages of negotiating a local MS Nurse specialist and will target the

appointment of an epilepsy nurse specialist in due course. I have set up a new

service for the administration of Botulinum toxin in patients with dystonia, spasticity

and chronic migraine. I aim to apply for the Clinical Lead for Neurology post in due

course.

Prepare to Lead 2009/10 – an NHS London leadership and mentoring scheme.

I applied for and was awarded a place on this competitive year-long educational

course funded and run by NHS London. The programme focuses on developing

clinicians who have the potential to become future leaders of high quality

healthcare within London. It aims to support clinicians in developing their skills in

the progression to senior positions with significant trust or strategic level

management and leadership responsibilities. The programme is run by NHS

London and is fully endorsed by the London Postgraduate Medical and Dental

Deanery.

NHS London Prepare to Lead meetings 2009-10 7th May Introduction to mentoring 25/26th Jun Power, Politics and Persuasion 6th July An evening with David Nicholson 1st Sept Working in Large Scale Private and Public Sector

Organisations 15th Oct Leading Quality Improvement 12th Nov Patient Safety 1st Dec Mid-year review workshop and dinner 14th Jan Emotional intelligence workshop 25th Feb Discussion with Ruth Carnell CEO NHS London 16th March Negotiating skills workshop 22nd March Discussion Forum with Directors of Care UK

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Dominic Paviour CV

Lead SpR at KCH 2009– This was both a leadership and management role.

As I started, a new EWTD compatible rota was required meaning I had to liaise with

HR, Medical Personnel and other SpRs as well as the consultants in the department

to manage the resources available and produce a functional working pattern for the

SpRs. This was difficult. I had little notice (4 weeks) to meet the deadline and had

resistant junior colleagues who I had to lead and motivate.

The rota was devised and started effectively but had to be implemented at same

time as a new thormbolysis service was started and so the increased intensity of

work ultimately led to failure of the rota. I learnt valuable lessons about service

development and implementation and the need for planning and foresight.

Senior Registrar at SGH 2009-11– This role has meant responsibility for

supervising other SpRs in clinical practice on the ward and liaising with consultant

colleagues. I have had responsibility for prioritising and organising admissions to the

neurology unit working with the neurosciences bed manager to achieve this. I have

organised a weekly MR imaging meeting for the last year, ensuring that interesting

cases are regularly discussed as part of on-going education. I have organised

regular neurological grand rounds and clinical demonstration sessions.

Teaching and Education

I am the P-Year lead for the year specific knowledge test (YSKT) which involves

delivering two (main and resit) 150 question MCQ papers across the medical and

surgical specialties every year. This involves leading and collaborating with

colleagues in order to produce the paper in a timely fashion.

I teach students in my weekly clinics and assess them at the end of their

attachments.

I deliver educational sessions to GPs and trainees on a regular basis. I have

excellent feedback.

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Dominic Paviour CV

I enjoy medical education and teaching and recognise it as an important aspect

of clinical governance that improves my own knowledge base and clinical

practice. It helps to ensure patient safety and the Temple report recommends

planned, focussed and individualised training within a consultant delivered

service, which I would embrace.

I value the feedback I receive from those I teach and have evidence of positive

formal and informal feedback. I have attended a number of formal courses to

improve my skills ensuring the teaching I deliver is planned and appropriate,

takes different kinds of learners into account and is therefore effective.

Teaching skills course at SGH Dec 2010

TIPS for teaching communication skills, UCL, December 2004.

Teaching TIPS for Teachers 2, Clinical and Bedside Teaching Skills, UCL,

Feb 2005.

Teaching TIPS for Teachers 3, Teaching and presenting to large groups,

UCL, Feb 2005.

I supervise and support junior colleagues as part of my current post and actively

encourage them to develop their clinical and academic skills. I am currently

supervising an F1 in a clinical audit that will lead to implementation of a ward-based

guideline. I have assisted junior colleagues in writing and publishing successfully.

In my current post I have established and lead a weekly SpR educational session

focussed on a “grey case” from the wards for reflective learning as well as a simple

approach to common neurological problems presenting to out-patients. The

feedback from these sessions is good and I summarise the sessions on single sides

of A4 and circulate these to those attending.

I lecture to large groups of medical SpRs and GP trainees for the Deanery. I have

also spoken to lay groups at fundraisers and at patient and carer meetings for the

PSP Association.

I have had positive feedback from these sessions and been asked to do more.

Most recently I have written modules for an on-line neurology educational resource

(e-Brain) on tau protein disorders as well as language dysfunction.

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Dominic Paviour CV

ResearchAs a consultant with primarily a clinical appointment encompassing 10+ PAs

delivering a clinical service, I have no time in my job plan for formal research.

Despite this, I am PI for 3 adopted studies at St George’s Hospital and am

involved in both therapeutic trials and observational studies, recruiting patients

from my busy movement disorders clinic.

I have extensive research experience as a junior academic but have decided to

focus on a clinical NHS career. However I have used my time in a Walport

funded Academic Clinical post constructively and I have continued to publish with

colleagues (4 peer reviewed papers in the last 18 months). I have also focused

on service development and education.

I spent 4 years working towards my PhD at the Institute of Neurology, UCL

successfully defending it in 2006. The focus of my PhD was the application of

magnetic resonance imaging (MRI) as a clinical and research tool in

neurodegenerative movement disorders. Specific aspects of my work related to

application of MRI as a diagnostic tool and as a biomarker of disease

progression.

I have published my work in clinical and scientific journals (more than 25 peer

reviewed publications to date, 12 as first author) and have presented my

research at numerous international academic meetings, demonstrating my ability

to communicate research methodology and results effectively.

I continue to review manuscripts for a number of journals, maintaining my ability

to critically appraise clinical and scientific research and its application in day-to-

day clinical practice as part of evidence based medicine.

Unlike many other candidates I have experience of research in the

pharmaceutical industry having spent 6 months working at the GSK Clinical

Imaging Centre as an out-of programme experience (OOPE). This has given me

a valuable insight into the regulation of pharmaceutical research and of using

“standard operating procedures” to ensure consistency and safety.

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Dominic Paviour CV

As a consequence of my time spent in Research I have developed key

transferable skills in the following areas: time management; scientific writing;

statistical data analysis; IT skills; team working and communication.

PublicationsBook Chapters

1. Clinical Biochemistry: Metabolic and Clinical Aspects, Chapter 35, Biochemistry of Neurological disease - Biochemistry of Movement Disorders, Paviour D, Editors William J Marshall 2013 In Press

2. Neuroimaging in Dementia, Chapter 5.4.3-5 PSP, MSA and CBD, Paviour D, Editors Barkhof, Fox, Bastos-Leite and Scheltens. Sptinger 2011.

3. Paediatric movement disorders Paviour D, Lees A, In Paediatric movement disorders. Editors: Fernández-Alvarez E, Arzimanoglou A, Tolosa E. 91-111. John Libbey Eurotext 2005

Peer reviewed publications

1. The midbrain to pons ratio: a simple and specific MRI sign of progressive supranuclear palsy. Massey LA, Jäger HR, Paviour DC, O'Sullivan SS, Ling H, Williams DR, Kallis C, Holton J, Revesz T, Burn DJ, Yousry T, Lees AJ, Fox NC, Micallef C. Neurology. 2013 May 14;80(20):1856-61. Epub 2013 Apr 24.

2. Conventional magnetic resonance imaging in confirmed progressive supranuclear palsy and multiple system atrophy. Massey LA, Micallef C, Paviour DC, O'Sullivan SS, Ling H, Williams DR, Kallis C, Holton JL, Revesz T, Burn DJ, Yousry T, Lees AJ, Fox NC, Jäger HR. Mov Disord. 2012 Dec;27(14):1754-62. doi: 10.1002/mds.24968. Epub 2012 Apr 4.

3. Difference in MSA Phenotype Distribution between Populations: Genetics or Environment? Ozawa T, Revesz T, Paviour D, Lees AJ, Quinn N, Tada M, Kakita A, Onodera O, Wakabayashi K, Takahashi H, Nishizawa M, Holton JL. J Parkinsons Dis. 2012;2(1):7-18. doi: 10.3233/JPD-2012-11056.

4. PINK1: pumps, paraesthesia, punding and psychosis. Paviour DC, Marion MH.J Neurol. 2012 Jun;259(6):1241-2. doi: 10.1007/s00415-011-6327-z. Epub 2011 Nov 30. No abstract available.

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Dominic Paviour CV

5. Novel L284R MAPT mutation in a family with an autosomal dominant progressive supranuclear palsy syndrome – Rohrer J, Paviour DC Neurodegener Dis. 2011;8(3):149-52. Epub 2010 Sep 14.

6. Does corticobasal degeneration exist? A clinicopathological re-evaluation. Ling H, O'Sullivan SS, Holton JL, Revesz T, Massey LA, Williams DR, Paviour DC, Lees AJ.Brain. 2010 Jul;133(Pt 7):2045-57.PMID: 20584946

7. Juvenile levodopa-responsive Parkinsonism with early orobuccolingual dyskinesias and cognitive impairment. Espay AJ, Paviour DC, O'Sullivan JD, Schmidt RE, Revilla FJ, Metman LV. Mov Disord. 2010 Jul 28. [Epub ahead of print]PMID: 20669183

8. Progressive supranuclear palsy syndrome presenting as progressive nonfluent aphasia: a neuropsychological and neuroimaging analysis. Rohrer JD, Paviour D, Bronstein AM, O'Sullivan SS, Lees A, Warren JD. Mov Disord. 2010 Jan 30;25(2):179-88.PMID: 20077483

9. Nutritional optic and peripheral neuropathy: a case report. Nightingale LM, Paviour DC. Cases J. 2009 Jun 5;2:7762.PMID: 19830009

10.Paroxysmal hemicrania and POEMS syndrome: further evidence that neuropeptides are implicated in primary headache? Paviour DC, Ellis CM. Cephalalgia. 2008 Nov;28(11):1204-6. Epub 2008 Jul 15. No abstract available. PMID: 18644027

11.Chiari-1 malformation and the neck-tongue syndrome: cause or coincidence? Wong SL, Paviour DC, Clifford-Jones RE. Cephalalgia. 2008 Sep;28(9):994-5. Epub 2008 Jun 28. No abstract available. PMID: 18557983

12.MRI derived brain atrophy in PSP and MSA-P. Determining sample size to detect treatment effects. Paviour DC, Price SL, Lees AJ, Fox NC. J Neurol. 2007 Apr;254(4):478-81. Epub 2007 Mar 31.PMID: 17401522

13.Diffusion-weighted magnetic resonance imaging differentiates Parkinsonian variant of multiple-system atrophy from progressive supranuclear palsy. Paviour DC, Thornton JS, Lees AJ, Jäger HR. Mov Disord. 2007 Jan;22(1):68-74.PMID: 17089396

14.Holmes tremor: Application of modern neuroimaging techniques. Paviour DC, Jäger HR, Wilkinson L, Jahanshahi M, Lees AJ. Mov Disord. 2006 Dec;21(12):2260-2.PMID: 17013902

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Dominic Paviour CV

15.Regional brain volumes distinguish PSP, MSA-P, and PD: MRI-based clinico-radiological correlations. Paviour DC, Price SL, Jahanshahi M, Lees AJ, Fox NC. Mov Disord. 2006 Jul;21(7):989-96.PMID: 16602104

16.Longitudinal MRI in progressive supranuclear palsy and multiple system atrophy: rates and regions of atrophy. Paviour DC, Price SL, Jahanshahi M, Lees AJ, Fox NC. Brain. 2006 Apr;129(Pt 4):1040-9. Epub 2006 Feb 2.PMID: 16455792

17.Can the frontal assessment battery (FAB) differentiate bradykinetic rigid syndromes? Relation of the FAB to formal neuropsychological testing. Paviour DC, Winterburn D, Simmonds S, Burgess G, Wilkinson L, Fox NC, Lees AJ, Jahanshahi M. Neurocase. 2005 Aug;11(4):274-82.PMID: 16093228

18. Is sphincter electromyography a helpful investigation in the diagnosis of multiple system atrophy? A retrospective study with pathological diagnosis. Paviour DC, Williams D, Fowler CJ, Quinn NP, Lees AJ. Mov Disord. 2005 Nov;20(11):1425-30.PMID: 16007638

19.Neuronal intranuclear inclusion disease: report on a case originally diagnosed as dopa-responsive dystonia with Lewy bodies. Paviour DC, Revesz T, Holton JL, Evans A, Olsson JE, Lees AJ. Mov Disord. 2005 Oct;20(10):1345-9.PMID: 15966005

20.Characteristics of two distinct clinical phenotypes in pathologically proven progressive supranuclear palsy: Richardson's syndrome and PSP-parkinsonism. Williams DR, de Silva R, Paviour DC, Pittman A, Watt HC, Kilford L, Holton JL, Revesz T, Lees AJ. Brain. 2005 Jun;128(Pt 6):1247-58. Epub 2005 Mar 23.PMID: 15788542

21.Quantitative MRI measurement of superior cerebellar peduncle in progressive supranuclear palsy. Paviour DC, Price SL, Stevens JM, Lees AJ, Fox NC. Neurology. 2005 Feb 22;64(4):675-9.PMID: 15728291

22.Pathological substrate for regional distribution of increased atrophy rates in progressive supranuclear palsy. Paviour DC, Schott JM, Stevens JM, Revesz T, Holton JL, Rossor MN, Lees AJ, Fox NC. J Neurol Neurosurg Psychiatry. 2004 Dec;75(12):1772-5.PMID: 15548504

23.The spectrum of pathological involvement of the striatonigral and olivopontocerebellar systems in multiple system atrophy: clinicopathological correlations. Ozawa T, Paviour D, Quinn NP, Josephs KA, Sangha H, Kilford L, Healy DG, Wood NW, Lees AJ, Holton JL, Revesz T. Brain. 2004 Dec;127(Pt 12):2657-71. Epub 2004 Oct 27.PMID: 15509623

24.Voxel-based morphometry detects patterns of atrophy that help differentiate progressive supranuclear palsy and Parkinson's disease. Price S, Paviour D, Scahill R, Stevens J, Rossor M, Lees A, Fox N. Neuroimage. 2004 Oct;23(2):663-9.PMID: 15488416

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Dominic Paviour CV

25.Frontotemporal lobar degeneration with ubiquitin-only-immunoreactive neuronal changes: broadening the clinical picture to include progressive supranuclear palsy. Paviour DC, Lees AJ, Josephs KA, Ozawa T, Ganguly M, Strand C, Godbolt A, Howard RS, Revesz T, Holton JL. Brain. 2004 Nov;127(Pt 11):2441-51. Epub 2004 Sep 30.PMID: 15459024

26.Rapid onset of pergolide-induced pulmonary fibrosis in a patient with corticobasal degeneration. Simcock D, Paviour D. Hosp Med. 2004 Jun;65(6):372-3. No abstract available. PMID: 15222217

27.Rapidly progressive behavioral changes and parkinsonism in a 68-year-old man. Kleiner-Fisman G, Lang AE, Bergeron C, Burn DJ, Paviour DC. Mov Disord. 2004 May;19(5):534-43. No abstract available. PMID: 15133817

28.Punding in Parkinson's disease: its relation to the dopamine dysregulation syndrome. Evans AH, Katzenschlager R, Paviour D, O'Sullivan JD, Appel S, Lawrence AD, Lees AJ. Mov Disord. 2004 Apr;19(4):397-405.PMID: 15077237

29.Diagnostic considerations in juvenile parkinsonism. Paviour DC, Surtees RA, Lees AJ. Mov Disord. 2004 Feb;19(2):123-35. Review.PMID: 14978667

30.Delineating the sites and progression of in vivo atrophy in multiple system atrophy using fluid-registered MRI. Schott JM, Simon JE, Fox NC, King AP, Khan MN, Cipolotti L, Paviour DC, Stevens JM, Rossor MN. Mov Disord. 2003 Aug;18(8):955-8.PMID: 12889090

PresentationsInvited talksCLINICAL FEATURES OF PD AND ATYPICAL PARKINSONISM8th International Conference on Alzheimer`s and Parkinson`s Diseases (AD/PD 2007) Salzburg, Austria March 14-18, 2007.

Platform presentationsMRI derived brain atrophy rates in PSP and MSA-P: clinical correlations and sample sizes. Paviour D, Price SL, Lees AJ, Fox NC 10th International Congress of Parkinson's Disease and Movement Disorders, Kyoto, JAPAN, 30 Oct 2006 - 02 Nov 2006. MOVEMENT DISORDERS.

Assessing disease progression using longitudinal Imaging. Paviour DC5th international Medical Workshop of the Progressive-Supranuclear-Palsy-Association, London, ENGLAND, 08 Jul 2005. MOVEMENT DISORDERS.

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Dominic Paviour CV

Poster presentations – (1st or 2nd author, presenting author in bold)

A systematic, comprehensive, blinded radiological study of MR findings in pathologically confirmed PSP, MSA and PD Massey L, Paviour D, O'Sullivan S, Burn D, Holton J, Revesz T, Lees A, Jager R, Micallef C 13th International Congress of Parkinsons Disease and Movement Disorders, Paris, FRANCE, 07 Jun 2009 - 11 Jun 2009.

Diffusion weighted MRI differentiates MSA-P from PSP Paviour D, Thornton JS, Lees AJ, Jager R 10th International Congress of Parkinson's Disease and Movement Disorders, Kyoto, JAPAN, 30 Oct 2006 - 02 Nov 2006. MOVEMENT DISORDERS.

Phenotypic variability in PSP: Unbiased analysis of serial MRI Paviour D, Price SL, Lees AJ, Fox NC 10th International Congress of Parkinson's Disease and Movement Disorders, Kyoto, JAPAN, 30 Oct 2006 - 02 Nov 2006. MOVEMENT DISORDERS.

Frontotemporal lobar degeneration with ubiquitin-only-immunoreactive neuronal changes presenting with the clinical phenotype of progressive supranuclear palsy (PSP) Paviour DC, Lees AJ, Josephs KA, Ozawa T, Ganguly M, Strand C, Godbolt A, Howard RS, Revesz T, Holton JL 106th Annual Meeting of the British-Neuropathological-Society, Inst Child Hlth, London, ENGLAND, 12 Jan 2005 - 14 Jan 2005.

The pathological basis of disproportionate antecollis in multiple system atrophy Ozawa T, Paviour D, Quinn NP, Revesz T, Holton JL, Lees AJ 9th International Congress of Parkinsons Disease and Movement Disorders, New Orleans, LA, 05 Mar 2005 - 08 Mar 2005.

The spectrum of pathological involvement of multiple system atrophy (MSA): clinicopathological correlations Ozawa T, Paviour D, Quinn NP, Lees AJ, Josephs KA, Healy DG, Wood NW, Holton JL, Revesz T 106th Annual Meeting of the British-Neuropathological-Society, Inst Child Hlth, London, ENGLAND, 12 Jan 2005 - 14 Jan 2005.

Characteristics of two distinct clinical phenotypes observed in pathologically proven progressive supranuclear palsy: Richardson's syndrome and PSP-Parkinsonism Williams DR, Paviour DC, Watt HC, Lees AJ 8th International Congress of Parkinsons Disease and Movement Disoders, Rome, ITALY, 14 Jun 2004 - 17 Jun 2004.

VBM as a tool to identify regions which may aid differential diagnosis of PSP, PD and MSA using MRI. Price SL, Paviour DC, Scahill RI, Stevens JM, Lees AJ, Fox NC 8th International Congress of Parkinsons Disease and Movement Disoders, Rome, ITALY, 14 Jun 2004 - 17 Jun 2004.

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Dominic Paviour CV

Superior cerebellar peduncle volume measurement on MRI differentiates progressive supranuclear palsy (PSP) from multiple system atrophy (MSA), Parkinson's disease (PD) and controls Paviour DC, Price SL, Stevens J, Lees AJ, Fox NC 8th International Congress of Parkinsons Disease and Movement Disoders, Rome, ITALY, 14 Jun 2004 - 17 Jun 2004.

Volumetric MRI studies in progressive supranuclear palsy Fox N, Paviour D 4th International Medical Workshop of the Progressive-Supranuclear-Palsy-Association, Buckinghamshire, ENGLAND, 21 Jul 2003.

Picturing atrophy patterns of Progressive Supranuclear Palsy (PSP) in vivo using fluid registered MRI Paviour DC, Schott JM, Fox NC, Stevens JM, Lees AJ, Rossor MN 7th International Congress of Parkinsons Disease and Movement Disorders, MIAMI, FLORIDA, 10 Nov 2002 - 14 Nov 2002.

Picturing the atrophy patterns of progressive supranuclear palsy and multiple system atrophy in vivo using fluid registered MRI Schott JM, Paviour DC, Fox NC, Stevens JM, Lees AJ, Rossor MN Joint Meeting of the Association-of-British-Neurologists/British-Neuropsychiatry-Association, LONDON, ENGLAND, 02 Oct 2002 - 04 Oct 2002.

Courses and Meetings

I attend regular courses and educational meetings as part of continuing professional

development. Over the course of my time in research and SpR training these

include:

MDS 7th International meeting Miami – 2002.

Edinburgh advanced neurology course - 2003.

Botulinum Toxin in Neurological Practice Workshop, Queen square, January 2004.

AAN Annual meeting April 2004 – San Francisco

MDS 8th International meeting Rome – 2004.

Advanced Life Support (ALS) Provider, September 2005

Specialist Registrar Teaching Weekend in Epilepsy, Oxford, October 2005.

MDS 9th International meeting New Orleans – 2005

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Dominic Paviour CV

MDS 10th International meeting Kyoto – 2006

AD/PD 8th International conference Salzburg – platform presentation, March 2007

Management skills for middle grade doctors – London September 2007

RSM Optic Nerve Disorders Nature and Nurture – November 2008

RSM The story of Polymyositis – October 2008

NIHR – The importance of measurement in neurodegenerative diseases – Oct 2008

The role of the physician in drug development – Oct 2008 GSK House

RSM – Advances in cerebrovascular disease June 2008

RSM Frontiers in the degenerative dementias June 2008

RSM Henry Barnes lecture – Aspiring to translate research into practice October 2008

UCL Neuro-ophthalmology short course – May 2008 (including cases presented)

8th KCH London Neuromuscular Disease symposium November 2008

UK Parkinson’s Disease Forum –Funded by Orion Pharma November 2008

EFNS Florence August 2009

Good Clinical Practice Guideline and EU GCP Directives − Good Clinical Practice Guideline Course – 2009

NHS London Prepare to Lead – mentoring scheme – 2009-10

ABN – London meeting - Sept 2010.

St George’s Clinical Ethics Committee – Training Course September 2010.

London school of Medicine and Medical specialties leadership & innovation conference – March 2011.

BASP Stroke Thrombolysis Course April 2011.

MDS international conferences 2012 (Dublin) and 2013 Sydney.

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Dominic Paviour CV

Referees

Details provided upon request

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