curriculum vitae university of pittsburgh school of ... · pdf filecurriculum vitae university...

Curriculum Vitae Satdarshan (Paul) Monga, M.D. Revision date: Jan. 2009

CURRICULUM VITAE University of Pittsburgh

School of Medicine

BIOGRAPHICAL Name: Satdarshan P. Singh Monga Birth Date: August 19, 1971 Home Address: 1606 English Oak Court Birth Place: Patiala, Punjab, India

Wexford, PA 15090 Home Phone: (724) 935-4483 Citizenship: USA Office Address: S421 BST, 200 Lothrop Street Email: [email protected] Pittsburgh, PA 15261 [email protected]

Business Phone: (412) 648-9966 Fax: (412) 648-1916 Web: http://www.pathology.pitt.edu/people/Faculty/Monga.htm http://gi.medicine.pitt.edu/personnelDetail.asp?pid=459&id=49&ptype=2&pnavcat=2 http://www.mirm.pitt.edu/people/bios/Monga1.html

EDUCATION and TRAINING

UNDERGRADUATE: 1986-1988 MM Modi College, Patiala, F.Sc Biology Punjab, India GRADUATE: 1988-1992 Dayanand Medical College & M.D. Medicine Hospital, Ludhiana and Punjab (M.B.B.S) & Surgery University, Chandigarh, India 1993 DMC & H, Ludhiana, Punjab, 1993 Internship India POSTGRADUATE: 1996-1997 Georgetown University Hospital Research Gastroenterology/ & Dept of Veterans Affairs Medical Fellow Molecular Biology

Center, Washington, D.C 1997-1999 Fels Cancer Institute Temple Postdoctoral Gastroenterology/ University, Hospital, Fellow Molecular Biology/ Philadelphia PA Development


APPOINTMENTS and POSITIONS

ACADEMIC: 1999-2001 University of Pittsburgh, School of Medicine Research Associate

Department of Pathology 2001-2003 University of Pittsburgh, School of Medicine Research Assistant Division of Cellular & Molecular Pathology Professor 2001-present McGowan Institute of Regenerative Medicine Member faculty

Liver Section, University of Pittsburgh, SOM 2002-present University of Pittsburgh Cancer Institute Member faculty

Molecular and Cellular Biology Program 2002-2005 McGowan Institute of Regenerative Medicine Director Graduate Student Network (now MTCAP) 2003-2007 University of Pittsburgh, School of Medicine Assistant Professor of

Division of Cellular & Molecular Pathology Pathology 2004-2007 University of Pittsburgh, School of Medicine Assistant Professor of

Division of Gastroenterology Medicine 2005-present McGowan Institute of Regenerative Medicine Director

Trainee Career Advancement Program (MTCAP) 2007-present University of Pittsburgh, School of Medicine Associate Professor of

Division of Cellular & Molecular Pathology Pathology 2007-present University of Pittsburgh, School of Medicine Associate Professor of

Division of Gastroenterology Medicine

2008-present University of Pittsburgh, School of Medicine Division Director Division of Experimental Pathology NON-ACADEMIC: 1994-1995 Monga Nursing Home/Hospital, Bareta, Residential Medical

Punjab, India Officer

1995-1996 Dayanand Medical College & Hospital Medical Officer In-Charge Dept. of Social & Preventive Medicine, Ludhiana, Punjab, India


CERTIFICATION and LICENSURE

Medical Licensure:

Punjab Medical Council, Chandigarh, India 1992

Medical Degree: Punjab University, Chandigarh, India 1994

MEMBERSHIP in PROFESSIONAL and SCIENTIFIC SOCIETIES American Association for The Study of Liver Diseases (AASLD) 2006-present American Society of Investigative Pathology (ASIP) 2002-present American Association of Cancer Research (AACR) 2001-present American Gastroenterology Association (AGA) 1999-present

Society of Developmental Biology (SDB) 1997-2005

HONORS AND AWARDS

Co-Moderator, Hepatobiliary Cancer, Translational 2008 AASLD Parallel Session XVIII Organizer, FASEB summer research conference for 2010 2008 Liver growth, Development and Disease Hepatology Editorial Board 2009 Accepted to be the Editor of Book entitled ‘Molecular Pathology 2008 Of Liver Diseases’ Springer (2010) Associate Editor 2008 American Journal of Pathology Guest Editor, Journal of ORGANOGENESIS (April) 2008 Chair, Stem Cell, Focused Research Group, AASLD annual 2007 meeting, Boston Chair, AASLD Research Forum entitled ‘Gene Expression and 2007 Cell Signaling’, Digestive Diseases Week’, Washington DC


Program Chair –Elect for the American Society of Investigative 2007 Pathology Chair, Liver Symposia at ASIP annual meeting at EB 2007 2007 ‘Pathobiology of ASH and NASH’ Chair, Stem Cell Symposia at ASIP annual meeting 2007 Experimental Biology 2007 Annual Conference Senior Vice Chancellor Award, University of Pittsburgh, SOM 2006 Nominated for Amgen Outstanding Investigator Award, 2007, 2006 American Society of Investigative Pathology Invited presenter at Harry and Elsa Jiler- 2005 American Cancer Society Professors Meeting Invited speaker at the Annual Science 2005 meeting at the University 2005 Of Pittsburgh, SOM Chair, Liver Workshop, ASIP, San Francisco 2005 FASEB, Experimental Biology: 2005 Annual Conference Chair, Neoplasia Symposium, ASIP, San Francisco 2005 FASEB, Experimental Biology: 2005 Annual Conference Vice Chair, Stem cells Poster discussion session, ASIP 2004 FASEB, Experimental Biology: 2004 Annual Conference American Cancer Society, Research Scholar Award (Rank-1/43) 2003 Plenary Poster of Distinction at the annual American Gastroenterology 2003 Association meeting, Digestive Diseases Week (DDW)-2003

Chairperson and Guest of Honor at the 35th Annual Conference 2002 of Indian Pharmacological Society (26-29 November, 2002) President Plenary Abstract Presentation, Advances in GI Oncology 2002 at the AGA meeting, DDW-2002 Pathology Postdoctoral Research Training Award 2000 President Plenary Abstract Presentation at the annual AGA meeting, 1999 DDW-1999 Plenary Poster of Distinction at the AGA meeting, DDW-1999 1999 Nominated for AASLD’s ‘Fellow of the Year’ Award 1998


PUBLICATIONS

Refereed articles

1. Cieply B, Zeng G, Singh T-P, Geller DA, Monga SP. Unique phenotype of hepatocellular cancers with exon-3 mutations in beta-catenin gene. Hepatology 2008 Oct 24 (In Press).

2. Tan X, Yuan, Y, Zeng G, Apte U, Thompson M, Cieply B, Stolz D,

Michalopoulos GK, Kaestner KH, Monga SP. β-Catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development. Hepatology. 2008 May;47(5):1667-79.

3. Zeng G, Apte U, Cieply B, Monga SP. siRNA-mediated β-catenin knockdown in

human hepatoma cells results in decreased growth and survival. Neoplasia. 2007 Nov;9(11):951-9.

4. Sharrow AC, Li Y, Micsenyi A, Griswold RD, Wells A, Monga SP, Blair HC.

Modulation of osteoblast gap junction connectivity by serum, TNFalpha, and TRAIL. Exp Cell Res. 2008 Jan 15;314(2):297-308. Epub 2007 Oct 23.

5. Guo D, Sarkar J, Suino-Powell K, Xu Y, Matsumoto K, Jia Y, Yu S, Khare S,

Haldar K, Rao MS, Foreman JE, Monga SP, Peters JM, Xu HE, Reddy JK. Induction of nuclear translocation of CAR by PPARalpha synthetic ligands in mouse liver. J Biol Chem. 2007 Oct 25; [Epub ahead of print]

6. Apte U, Thompson M, Cui S, Liu B, Cieply B, Monga SP. Wnt/β-catenin

signaling mediates oval cell response in rodents. Hepatology. 2008 Jan;47(1):288-95. [Epub ahead of print 2007 Oct 10]

7. Muller P, Monga DK, Tan X, Micsenyi A, Loizos N, Monga SP. PDGFRα: A

novel therapeutic target in HCC. Molecular Cancer Therapeutics, 2007 Jul;6(7):1932-41.

8. Apte U, Zeng G, Thompson M, Muller P, Micsenyi A, Cieply B, Kaestner KH,

Monga SP. β-Catenin is critical for early postnatal liver growth. Am J Physiol Gastrointest Liver Physiol. 2007 Jun;292(6):G1578-85. Epub 2007 Mar 1.

9. Behari J, Thompson M, Muller P, Zeng G, Micsenyi A, Sekhon S, Leoni L and

Monga SP. R-Etodolac decreases β-catenin levels along with survival and proliferation of hepatoma cells. J Hepatol. 2007 May;46(5):849-57.

10. Zeng G, Apte U, Micsenyi A, Cieply B, Gandhi C, Demetrius A, Monga SP.

Wnt’er in Liver: expression of Wnt and frizzled genes in mouse. Hepatology. 2007 Jan;45(1):195-204.

11. Tan X, Behari J, Cieply B, Michalopoulos GK, Monga SP. Beta-catenin

knockout reveals its role in liver growth and regeneration. Gastroenterology. 2006 Nov;131(5):1561-72. (Accompanying Editorial).


12. Apte U, Micsenyi A, Muller P, Zeng G, Kaestner K, Monga SP. Role of β-catenin in HGF-induced hepatomegaly in mice. Hepatology. 2006 Oct;44(4):992-1002.

13. Luo JH, Ren B, Keryanov S, Tseng GC, Rao U, Monga SP, Strom S, Demetris

AJ, Nalesnik M, Yu YP, Ranganathan S and Michalopoulos GK. Transcriptomic and Genomic analysis of Human Hepatocellular Carcinomas and Hepatoblastomas. Hepatology 2006 Oct;44(4):1012-24.

14. Zeng G, Apte U, Micsenyi A, Bell A, Monga SP. Tyrosine residues 654 and

670 in β-catenin are crucial in regulation of Met-β-catenin interactions. Exp Cell Res. 2006 Aug 10. (HIGHLIGHT SECTION)

15. Zeng G, Germinaro M, Micsenyi A, Monga NK, Bell A, Sood A, Malhotra V,

Sood N, Midda V, Monga DK, Kokkinakis DM, Monga SP. Aberrant Wnt/β-Catenin Signaling In Pancreatic Adenocarcinoma. Neoplasia 2006, April:8(4):279-289.

16. Monga SP, Micsenyi A, Germinaro M, Apte UM, Bell A. Beta-catenin regulation

during matrigel-induced rat hepatocyte differentiation. Cell Tissue Res. 2006 Jan;323(1):71-9. Epub 2005 Sep 14.

17. Monga SP, Hout, M, Baun, M, Micsenyi A, Muller P, Tummalapalli, Ranade,

AR, Luo JH, Strom SC, Gerlach JC. Mouse fetal Liver Cells in artificial capillary beds in 3-D four-compartment bioreactors. American Journal of Pathology Am J Pathol. 2005 Nov;167(5):1279-92. (Cover Photo).

18. Ranganathan, S, Tan, X, Monga SP. β-Catenin and Met deregulation in

childhood hepatoblastomas. Pediatric and Developmental Pathology. Pediatr Dev Pathol. 2005 Jul-Aug;8(4):435-47. Epub 2005 Oct 5.

19. Tan X, Apte U, Micsenyi A, Kotsagrelos E, Luo JH, Ranganathan S, Monga

DK, Bell A, Michalopoulos GK, Monga SP. EGFR: A novel target of the wnt/β-catenin pathway in liver. Gastroenterology. 2005 Jul;129(1):285-302.

20. Sodhi D, Micsenyi A, Bowen WC, Monga DK, Lopez Talavera JC, Monga SP.

Morpholino oligonucleotide-triggered β-catenin knockdown compromises normal liver regeneration. J Hepatol. 2005 Jul;43(1):132-41.

21. Sekhon SS, Tan X, Micsenyi A, Bowen WC, Monga SP. FGF enriches the

embryonic liver cultures for hepatic progenitors. The American Journal of Pathology. Am J Pathol. 2004 Jun;164(6):2229-40.

22. Kohler C, Bell AW, Bowen WC, Monga SP, Fleig W, Michalopoulos GK.

Expression of Notch-1 and its ligand Jagged-1 in rat liver during liver regeneration. Hepatology. 2004 Apr;39(4):1056-65.

23. Micsenyi A, Tan X, Sneddon T, Michalopoulos GK, Monga SP. β-Catenin is

Temporally Regulated During Normal Liver Development. Gastroenterology 2004 Apr;126(4):1134-46


24. Hussain SZ, Tan X, Micsenyi A, Sneddon, T, Michalopoulos GK, Monga, SP.

Wnt impacts growth and differentiation in ex vivo liver development. Exp Cell Res. 2004;292(1):157-169. (COVER PHOTO) (HIGHLIGHT SECTION)

25. Monga SP, Monga HK, Tan X, Mule K, Pediaditakis P, Michalopoulos GK.

Beta-catenin antisense studies in embryonic liver cultures: role in proliferation, apoptosis, and lineage specification. Gastroenterology. 2003 Jan;124(1):202-16. (COVER PHOTO)

26. Monga SP, Mars WM, Pediaditakis P, Bell A, Mule K, Bowen WC, Wang X,

Zarnegar R, Michalopoulos GK. Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes. Cancer Res. 2002 Apr 1;62(7):2064-71.

27. Pediaditakis P, Monga SP, Mars WM, Michalopoulos GK. Differential mitogenic

effects of single chain hepatocyte growth factor (HGF)/scatter factor and HGF/NK1 following cleavage by factor Xa. J Biol Chem. 2002 Apr 19;277(16):14109-15.

28. Bhanumathy CD, Tang Y, Monga SP, Katuri V, Cox JA, Mishra B, Mishra L.

Itih-4, a serine protease inhibitor regulated in interleukin-6-dependent liver formation: role in liver development and regeneration. Dev Dyn. 2002 Jan;223(1):59-69.

29. Pediaditakis P, Lopez-Talavera JC, Petersen B, Monga SP, Michalopoulos GK.

The processing and utilization of hepatocyte growth factor/scatter factor following partial hepatectomy in the rat. Hepatology. 2001 Oct;34(4 Pt 1):688-93.

30. Weinstein M, Monga SP, Liu Y, Brodie SG, Tang Y, Li C, Mishra L, Deng CX.

Smad proteins and hepatocyte growth factor control parallel regulatory pathways that converge on beta1-integrin to promote normal liver development. Mol Cell Biol. 2001 Aug;21(15):5122-31.

31. Monga SP, Pediaditakis P, Mule K, Stolz DB, Michalopoulos GK. Changes in

WNT/beta-catenin pathway during regulated growth in rat liver regeneration. Hepatology. 2001 May;33(5):1098-109. (COVER PHOTO)

32. Monga SP, Tang Y, Candotti F, Rashid A, Wildner O, Mishra B, Iqbal S, Mishra

L. Expansion of hepatic and hematopoietic stem cells utilizing mouse embryonic liver explants. Cell Transplant. 2001 Jan-Feb;10(1):81-9.

33. Monga SP, Wadleigh R, Sharma A, Adib H, Strader D, Singh G, Harmon JW,

Berlin M, Monga DK, Mishra L. Intratumoral therapy of cisplatin/epinephrine injectable gel for palliation in patients with obstructive esophageal cancer. Am J Clin Oncol. 2000 Aug;23(4):386-92.

34. Mishra L, Cai T, Yu P, Monga SP, Mishra B. Elf3 encodes a novel 200-kD

beta-spectrin: role in liver development. Oncogene. 1999 Jan 14;18(2):353-64.


35. Mishra L, Yu P, Cai T, Monga SP, Mishra B. Genomic structure, chromosomal mapping, and muscle-specific expression of a PH domain-associated intronless gene, cded/lior. Mamm Genome. 1999 Jan;10(1):62-7.

36. Monga SP, Wadleigh R, Adib H, Harmon JW, Berlin M, Mishra L. Endoscopic

treatment of gastric cancer with intratumoral cisplatin/epinephrine injectable gel: a case report. Gastrointest Endosc. 1998 Oct;48(4):415-7.

37. Cai T, Yu P, Monga SP, Mishra B, Mishra L. Identification of mouse itih-4

encoding a glycoprotein with two EF-hand motifs from early embryonic liver. Biochim Biophys Acta. 1998 May 29;1398(1):32-7.

38. Mishra L, Tully RE, Monga SP, Yu P, Cai T, Makalowski W, Mezey E, Pavan

WJ, Mishra B. Praja1, a novel gene encoding a RING-H2 motif in mouse development. Oncogene. 1997 Nov 6;15(19):2361-8.

Reviews, invited published papers, proceedings of conference and symposia, monographs, books and book chapters (Selected)

1. Nejak-Bowen K, Monga SP. Wnt/β-catenin signaling in hepatic organogenesis.

REVIEW. Organogenesis. 2008 (April/May/June);4(2): 92-99 2. Thompson, M, Monga SP. Wnt/β-catenin signaling in Liver Health and Disease.

REVIEW. Hepatology. 2007 May;45(5):1298-305.

3. Monga SP, Gerlach JC. Human fetal hepatocyte behavior in dynamic 3-D perfusion bioreactor culture. INVITED REVIEW. J of Organ Dysfunction. March 08, 2007. 1-10 (iFirst article).

4. Monga SP. Hepatic Adenomas: Presumed Innocent Until Proven Beta-catenin

Mutated! Hepatology, March 2006. (INVITED EDITORIAL).

5. Monga SP, Jaideep Behari. Molecular basis of Liver Disease. “Molecular Pathology”(ed Coleman and Tsongalis). Elsevier-2009. (BOOK CHAPTER)

6. Monga, SP, Michalopoulos, GK. Wnt/β-catenin signaling in Liver. “Signaling in

Liver Diseases” (ed Jean Dufour and P-A Clavien). Springer Verlag – 2005. (BOOK CHAPTER)

7. Mars, W., Liu, Y. and Monga, SP. Hepatocyte Growth Factor and its Receptor, Met

in “The Cytokine Handbook” (ed. Angus W. Thomson and Michael T. Lotze), 4th edition, Elsevier Science Ltd., (May 2003). (BOOK CHAPTER)


Published abstracts (partial list)

1. Cieply B, Monga SP. β-Catenin expression in Pediatric Malignancies. FASEB J; April 2008: A118#1124.9

2. Apte U, Stolz D, Monga SP. Interactions of β-catenin with Met and E-cadherin

during oval cell activation. FASEB J; April 2008: A113#1124.4

3. Cieply B, Monga SP. Using tyrosine-654 phosphorylation of β-catenin to predict HCC pathology. FASEB J; April 2008: A116#1124.7

4. Thompson M, Zeng G, Cieply B and Monga SP. Pegylated interferon attenuates

Wnt/β-catenin signaling in HCC. Hepatology, October 2007; 639. 5. Behari J, Monga SP. Loss of β-catenin excerbates MCD-induced steatohepatitis in

mice. Hepatology, October 2007; 1190.

6. Nejak-Bowen K, Zeng G, Monga SP. Regucalcin is a novel target of beta-catenin in liver. 867.7, FASEB J. April 2007.

7. Zeng G, Apte U, Cieply B, Monga SP. siRNA-mediated β-catenin knockdown in

human hepatoma cells results in their decreased growth and survival. 49.4, FASEB J, April 2007.

8. Apte U, Cui S, Liu B, Thompson M, Monga SP. Wnt/β-catenin pathway is critical

for oval cell activation in rats. 125.4, FASEB J, April 2007.

9. Thompson M, Micsenyi A and Monga SP. Pegged for destruction: beta-catenin as a novel target of pegylated interferon. FASEB J, April 2007.

10. Behari J, Cieply B, Otruba W, Apte U, Wu T and Monga SP. Liver specific beta-

catenin knockout mice show increased liver injury in the MCD model of steatohepatitis. 381.4, FASEB J, April 2007.

11. Apte U, Zeng Z, Kaestner K and Monga SP. Beta-catenin is essential for liver

regeneration following APAP-induced acute liver failure. 867.6, FASEB J, April 2007.

12. Tan X and Monga SP. Beta-catenin is a critical morphogen for gestational hepatic

development. 867.3, FASEB J, April 2007. 13. P Stock, D Monga, A Micsenyi, X Tan, Monga SP. PDGFRα is an oncofetal target

in human HCC. 867.17, FASEB J. April 2007

14. U.M. Apte, A. Micsenyi, P. Muller, B. Cieply and Monga SP. Rapid activation of beta-catenin during liver regeneration following acetaminophen-induced acute liver failure. 886.3, FASEB J. March 2006

15. X. Tan, Y. Yuan and Monga SP. Beta-catenin is essential for normal liver

development. 410.4, FASEB J. March 2006.


16. U.M. Apte, A. Micsenyi, P. Muller, B. Cieply and Monga SP. Rapid activation of

beta-catenin during liver regeneration following acetaminophen-induced acute liver failure. 886.3, FASEB J. March 2006.

17. U.M. Apte, P. Muller, F. Awan, W. Otruba, B. Cieply and Monga SP. Wnt/beta-

catenin pathway activation during normal postnatal liver growth and development. 686.2, FASEB J, March 2006.

18. F. Awan, W. Otruba, P. Muller, G. Zeng and Monga SP. Wnt’er in mouse liver.

686.3, FASEB J, March 2006.

19. X. Tan and Monga SP. beta-Catenin is essential in normal liver growth, regeneration and function. 686.5, FASEB J, March 2006

20. G. Zeng, A. Bell, A. Micsenyi and Monga SP. Regulation of Met-beta-catenin

interaction in hepatocytes by tyrosine phosphorylation. 686.6, FASEB J, March 2006.

21. Monga SP and A. Micsenyi. Pegylated interferon’s anti-hepatoma effect is

mediated by beta-catenin inhibition. 686.7, FASEB J, March 2006.

22. Prince JM, Baun MJ, Vallabhaneni R, Hout MS, Vodovotz Y, Billiar TR, Monga SP, Gerlach JC. Nitric Oxide Supports the Establishment of Primary Rat Liver Cells in a Four Compartment Bioreactor Culture Model. Regenerate World Congress on Tissue Engineering and Regenerative Medicine. Pittsburgh, PA, April, 2006.

23. Peggy Muller, Xinping Tan, Amanda Miscenyi, Benjamin Cieply, Jaideep Behari,

Monga SP. Beta-catenin is essential for normal liver growth and development. Hepatology, Volume 42, Issue S1, Pages 196A - 298A, October 2005.

24. Jaideep Behari, Peggy Muller, Amanda Miscenyi, Lorenzo Leoni, Monga SP. Beta-

catenin inhibition by cox-2-dependent and independent pathways is associatd with decreased proliferation and survival of hepatocellular carcinima cells. Hepatology, Volume 42, Issue S1, Pages 299A - 401A, October 2005.

25. U.M. Apte, P. Muller, X. Tan, A. Micsenyi, B. Cieply, C. Dai, Y. Liu, K.H. Kaestner

and Monga SP. beta-Catenin: a principal in vivo mediator of HGF-induced liver growth. 682.4, FASEB J, March 2006.

26. P. Müller, D. K. Monga, A. M. Micsenyi, G. Zeng, N. Loizos and Monga SP.

PDGFR alpha: a novel therapeutic target in human hepatocellular cancer. 855.4, FASEB J, March 2005.

27. G. Zeng, M. Germinaro, A. Micsenyi, N. K. Monga and Monga SP. Aberrant Wnt/

beta -catenin signaling in pancreatic adenocarcinoma in patients. 606.9, FASEB J, March 2005.

28. U. M. Apte, P. Muller, A. Micsenyi and Monga SP. Activation of Wnt/ beta -catenin

pathway during postnatal liver development. 607.2, FASEB J, March 2005.


29. U. M. Apte, A. Micsenyi and Monga SP. Modulation of Wnt/ beta -catenin pathway following acetaminophen-induced liver injury and regeneration. 296.5, FASEB J, March 2005.

30. X. Tan and S. S. Monga. Beta-Catenin conditional knockouts reveal its role in liver

growth and regeneration. 607.5, FASEB J, March 2005.

31. U. M. Apte, C. Dai, A. Micsenyi, Y. Liu and Monga SP. Activation of beta -catenin in HGF-induced hepatomegaly. 607.3, FASEB J, March 2005.

32. Prince JM, Baun MJ, Hout, MS, Meiers CA, Billiar TR, Monga SP, Gerlach JC.

Nitric Oxide (NO) Inhibits Liver Cell Death in a 3-Dimensional Bioreactor Culture Model. 2004 FASEB Summer Research Conferences Mechanisms of Liver Growth, Development, and Disease, Snowmass Village, CO, August, 2004.

33. Monga SP, D. S. Sodhi, D. S. Monga and J. S. Talavera. Beta -Catenin antisense

injection compromises liver regeneration in rats. 381.7, FASEB J, March 2004.

34. Monga SP, X. S. Tan and G. S. Michalopoulos. Liver specific beta -Catenin transgenic mice reveal EGFR as a potential target. 380.3, FASEB J, March 2004.

35. Monga SP, M. S. Hout, A. S. Micsenyi, M. S. Baun and J. S. Gerlach. Mouse fetal

hepatocyte culture in 3-D artificial capillary beds in bioreactors. 144.7, FASEB J, March 2004.

36. Monga SP, S. S. Sekhon, A. S. Micsenyi and W. S. Bowen. Fgf enriches the

embryonic liver cultures for hepatic progenitors. 144.8, FASEB J, March 2004.

37. Monga SP, X. S. Tan and S. S. Ranganathan. Beta -Catenin and c-myc immunohistochemistry: diagnostic implications in hepatoblastomas. 380.6, FASEB J, March 2004.

38. Monga SP, T. Sneddon, X. Tan and G.K. Michalopoulos. Characterization of

normal β-catenin transgenic mice. 163.1, FASEB J, March 2003.

39. Monga SP, A. Micsenyi, T. Sneddon, X. Tan and G.K. Michalopoulos. Tight temporal regulation of β-catenin during normal liver development. 665.8, FASEB J, March 2003.

40. Micsenyi, A., Sneddon, T., Tan, X., Michalopoulos, GK, Monga, SP. In vivo

checkpoints maintain tight temporal regulation of β-catenin during normal liver development. Proceedings of the AACR, March 2003;44:1297.

41. Monga, DK., Tan X., Sneddon, T., Koehler, C., Michalopoulos, GK., Monga, SP.

Erythropoietin, a potent negative regulator of β-catenin in hepatocytes and liver cancer cells. Proceedings of the AACR, March 2003;44:2391.

42. Hussain S., Tan X., Sneddon, T., Michalopoulos, GK, Monga, SP. Wnt induces

bile duct formation by promoting stem cell differentiation and survival in embryonic liver cultures. The FASEB Journal 2003 (April):6259.


43. Ranganathan, S., Tan, X., Michalopoulos, G.K., Monga, SP. Beta-catenin and met

analysis in hepatoblastomas. The FASEB Journal 2003 (April).

44. Monga, SP, Tamara Sneddon, Xinping Tan, George Michalopoulos. β-Catenin transgenic mice display hepatomegaly and pre-cancerous lesions. Suppl. To Gastroenterology, May 2003: M965.

45. Sandeep Sekhon, Xinping Tan, William Bowen, George Michalopoulos, Monga,

SP. Fibroblast Growth Factors Promote Hepatocyte Stem Cell Renewal in Embryonic Liver Cultures. Suppl. To Gastroenterology, May 2003: S946.

46. Sandeep S. Sekhon, Tamara Sneddon, William Bowen, George Michalopoulos,

Monga, SP. Selective cox-2 inhibitor in liver cancer cells: role and mechanism. Suppl. To Gastroenterology, May 2003:T984.

47. Monga, DK., Hussain, S., Tan X., Sneddon, T., Koehler, C., Michalopoulos, GK.,

Monga, SP. PDGFR-α and IGFBP5 upregulation in early liver development and liver cancer cells. Suppl to Journal of Clinical Oncology, June 2003.

48. Monga, SP, Peter Pediaditakis, Aaron Bell, George K. Michalopoulos. β_Catenin

antisense studies in embryonic liver culture-role in proliferation, apoptosis and lineage specification. The FASEB Journal 2002, 16;4:291.2.

49. Monga, SP, Wendy Mars, Peter Pediaditakis, William C. Bowen, George K.

Michalopoulos. HGF induces Wnt independent nuclear translocation of β-catenin following Met-β-catenin dissociation in normal rat hepatocytes. Proceedings of the American Association of Cancer Research. March 2002;43:3317.

50. Monga, SP, Peter Pediaditakis, Christoph Koehler, Aaron Bell, George K.

Michalopoulos. β-catenin stabilization: a crucial event in hepatocyte differentiation in primary cultures. Proceedings of the American Association of Cancer Research. March 2002;43:4898.

51. Monga, SP, Wendy Mars, Peter Pediaditakis, William C. Bowen, George K.

Michalopoulos. HGF induces Wnt independent nuclear translocation of β-catenin following Met-β-catenin dissociation in normal rat hepatocytes. Suppl to Gastroenterology 2002, 122;4:134.

52. Monga, SP, Wendy Mars, George K. Michalopoulos. Wnt/beta-catenin pathway

during liver regeneration, a crucial checkpoint defined in regulated growth environment. AACR (2001): 3950.

53. Monga, SP, P. Pediaditakis and G.K. Michalopoulos. HGF induces Wnt-1

independent nuclear translocation of beta-catenin through association of c-met and beta-catenin in rat hepatocytes. AACR (2001):3725.

54. Monga, SP, T-H Kim, P. Pediaditakis and G.K. Michalopoulos. Beta-catenin

modulates cell-cell adhesion in rat liver regeneration and primary hepatocyte cultures. FASEB Journal 2000;14(4):A285.


55. Monga, SP, S. Danovitch, A. Rashid, B. Mishra, T. Fleury, L. Mishra. Correlation of

inhibition studies of elf-3, a beta-spectrin, with primary biliary cirrhosis. Gastroenterology 1999

56. Monga, SP, S. Danovitch, B. Mishra, L. Mishra. Disruption of TGF-beta signal by

smad 2, 3 & ELF spectrin in Primary Biliary Cirrhosis. Hepatology 1999;30(4-2):964.

57. Monga, SP, M. Weinstein, C. Deng, L. Mishra. Essential cooperative function of

TGF-beta signaling molecules smad 2/3 for liver function can be rescued by HGF. Hepatology 1999;30(4-2):629.

58. Monga, SP, M. Weinstein, A. Rashid, L. Mishra, C. Deng. Smad 2/3 define an

essential developmental checkpoint in liver formation. Gastroenterology 1999.

59. Monga, SP, B. Mishra, D. Dhanasekhran, L. Mishra. Praja-1, a novel ring finger protein, involved in hepatocyte apoptosis, selectively expressed in hepatocyte stem cells. Gastroenterology 1999.

60. Monga, SP, R. Wadleigh, H. Adib, D.K. Monga, J. Harman, L. Mishra. Endoscopic

intratumoral injection of cisplatin/epinephrine therapeutic injectable gel as palliative treatment for esophageal cancer. Gastroenterology 1998;114(4-2):G2660.

61. T. Cai, Monga, SP, P. Yu, B. Mishra, L. Mishra. elf, a novel beta- spectrin in liver

and bile duct development. Developmental biology 1998;198(1):67.

62. P. Yu, T. Cai, Monga, SP, B. Mishra, L. Mishra. Structure and expression of Cded, a novel gene encoding a pH domain, maps to the distal portion of chromosome 2. Gastroenterology 1998;114(4-2):L0706.

63. Monga, SP, A. Rashid, A. Diehl, B. Mishra, L. Mishra. Functional characterization

of Itih-4, a scaffolding protein isolated from developing liver. Hepatology 1998;28(4-2):38.

64. Monga, SP, A. Rahman, A. Subramanian, L.Mishra. Early liver development is

heralded by scaffolding, anchoring and trafficking proteins, important in the generation of structural and functional polarity. Hepatology 1998;28(4-2):35.

65. Monga, SP, J. Lee, H.Z. Lin, A.M. Diehl, A. Rashid, L. Mishra. PRAJA-1 and ELF

cell polarity protein from developing liver expressed at different and distinct time points during liver regeneration. Hepatology 1998;28(4-2):63.

66. Monga, SP, D. Kruse, R. Redman, B. Mishra, L. Mishra. A novel ring finger protein

PRAJA-1 is required for maintenance of developing liver architecture. Hepatology 1998;28(4-2):910.


67. Monga, SP, A. Rashid, O. Wildner, F. Condotti, B. Mishra, L. Mishra. Growth and culture of hepatic stem cells utilizing liver explant cultures. Developmental Biology 1998;198(1):30.

68. Monga, SP, R. Wadleigh, H. Adib, D.K. Monga, J. Harman, L. Mishra. Endoscopic

intratumoral injection of cisplatin/epinephrine therapeutic injectable gel as palliative treatment for esophageal cancer. Gastroenterology 1998;114(4-2):G2660.

69. Monga, SP, A. Rashid, O. Wildner, F. Condotti, B. Mishra, L. Mishra. Growth &

culture of hepatic stem cells in liver explant cultures. Hepatology 1998 (4-2):1763.

70. Monga, SP, A. Rashid, O. Wildner, F. Condotti, B. Mishra, L. Mishra. Growth and culture of hepatic stem cells utilizing liver explant cultures. Developmental Biology 1998;198(1):300.

71. Monga, SP, R.E Tully, T. Cai, L. Kos, B. Mishra, W. Pavan, L. Mishra. LIV 88, a

novel Goliath related gene encoding a Ring-H2 motif in hepatocyte growth and differentiation. Gastroenterology 1997;112(4):A1336.

PROFESSIONAL ACTIVITIES TEACHING Current teaching administration:

o Course Director, Stem Cells: 2002-present o Course Director, Research Seminars in 2003-present

Regenerative Medicine (CATER seminars)

Current teaching activity (Graduate School):

o Course – MSCMP 2730: Molecular Mechanisms of Tissue Growth & Differentiation Dates of Course – January 2002 Number of Students – 8 Type of Students – Graduate Number of lectures – 1 Contact Hours – 1

o Course – MSCMP 3740: Stem Cells (2.0 credits) Dates of Course – Fall 2002 No. of students – 14 Type of Students – Graduate (Interdisciplinary and Bioengineering) Number of lectures – 2 Contact Hours – 16


o Course – MSCMP 2730: Molecular Mechanisms of Tissue Growth & Differentiation

(3.0 credits) Dates of Course – January 2003 Number of Students – 12 Type of Students – Graduate Number of lectures – 1

o Contact Hours – Course – MSCMP 3740: Stem Cells (3.0 credits) Dates of Course – Fall 2003 Number of Students – 20 Type of Students – Graduate (Interdisciplinary and Bioengineering) Number of lectures – 3 Contact Hours – 40

o Course – MSCMP/BIOENG3760CRN467301: Research Seminars in Regenerative Medicine/CATER seminar series (1.0 credit) Dates of Course – Fall 2003 Number of Students – 13 Type of Students – Graduate (Interdisciplinary and Bioengineering) Number of lectures – 1 Contact Hours – 8

o Course – MSCMP 2730: Molecular Mechanisms of Tissue Growth & Differentiation (3.0 credits)

Dates of Course – January 2004 Number of Students – 9 Type of Students – Graduate Number of lectures – 1

o Course – MSCMP/BIOENG3760CRN467301: CATER Seminar Series (1.0 credit) Dates of Course – Spring 2003 Number of Students – 13 Type of Students – Graduate (Interdisciplinary and Bioengineering) Number of lectures – 1 Contact Hours – 8

o Course – MSCMP 3740: Stem Cells (3.0 credits)

Dates of Course – Fall 2004 Number of Students – 12 Type of Students – Graduate (Interdisciplinary and Bioengineering) Number of lectures – 2 Contact Hours – 30

o Course – MSCMP/BIOENG3760CRN467301: CATER Seminar Series (1.0 credit)



o Course – MSCMP 2730: Molecular Mechanisms of Tissue Growth & Differentiation

(3.0 credits) Dates of Course – January 2005 Number of Students – 12 Type of Students – Graduate Number of lectures – 1


o Course – MSCMP 3740: Stem Cells (3.0 credits) Dates of Course – Fall 2005 Number of Students – 14 Type of Students – Graduate (Interdisciplinary and Bioengineering) Number of lectures – 2 Contact Hours – 30

o Course – MSCMP/BIOENG3760CRN467301: CATER Seminar Series (1.0 credit) Dates of Course – Fall 2005 Number of Students – 15 Type of Students – Graduate (Interdisciplinary and Bioengineering) Number of lectures – 0 Contact Hours – 6




Dates of Course – Spring 2006 Number of Students – 15 Type of Students – Graduate (Interdisciplinary and Bioengineering) Number of lectures – 0 Contact Hours – 6









o Course – MSCMP 3740: Stem Cells (3.0 credits) Dates of Course – Fall 2007 Number of Students – 17 Type of Students – Graduate (Interdisciplinary and Bioengineering) Number of lectures – 2 Contact Hours – 30







o Course – MSCMP/BIOENG3760CRN467301: CATER Seminar Series (1.0 credit) Dates of Course – Fall 2008 Number of Students – 12 Type of Students – Graduate (Interdisciplinary and Bioengineering) Number of lectures – 0 Contact Hours – 7



Current teaching activity (Medical School):

o Course – Digestion and Nutrition; Histology & Pathology Laboratories

Dates of Course – November and December 2001 Number of students – 15 Type of Students – MS2 (class of 2004) Number of lectures – 7 Contact Hours – 7

o Course – Digestion and Nutrition, Gastroenterology Dates of Course – November and December 2001 Number of students – 12 Type of Students – MS2 (class of 2004) Number of PBLs – 6 Contact Hours – 8

o Course – Digestion and Nutrition; Histology & Pathology Laboratories

Dates of Course – December 2002 Number of students – 50 Type of Students – MS2 (class of 2005) Number of lectures – 1 Contact Hours – 1

o Course – Digestion and Nutrition, Gastroenterology Dates of Course – December 2004 and January 2005 Number of students – 12 Type of Students – MS2 (class of 2004) Number of PBLs – 6 Contact Hours – 8

o Course – Digestion and Nutrition, Gastroenterology Dates of Course – December 2005 Number of students – 12 Type of Students – MS2 (class of 2004) Number of PBLs – 2 Contact Hours – 3




OTHER TEACHING ACTIVITY:

Service on Ph.D. student thesis committees: Saurabh Kharait Pathology 2003-2005 Vlad Sandulache Pathology/CATER 2004-2006 Vasiliki Gkretsi Pathology 2004-2006

Timothy Maul Bioengineering/CATER 2004-2007 Christopher Shepard Pathology 2005-2007 Xin He Pathology 2005-2008 Kristi Kolarcik Pathology 2006-present Dan Wang Pathology 2006-present Bowen Liu Pathology 2007-present Li Zou Bioengineering 2007-present Kun-Wei Liu Pathology 2008-present Stephanie Poe Medicine 2008-present Service on postdoctoral trainee committees

Pal Kaposi-Novak, M.D. PGY2 (Pathology, PIRT Program) 2008

Supervision of undergraduate students Emily Boyd Graduate Student (Interdisciplinary) 2005 Matthew Germinaro Biology (SURP) 2003, 2004 Amanda Micsenyi Biology (SURP and Undergraduate Lab) 2002, 2003 Emorphia Kotsegrelos Biology (SURP) 2001 Hardarshan Madan Biology (Undergraduate- Chatham College) 2001

Supervision of predoctoral graduate students

Kari Nejak-Bowen Graduate Student (Interdisciplinary) 2006-present Nisha Sambamurthy Graduate Student (Interdisciplinary) 2007 Shanshan Cui Graduate Student (Interdisciplinary) 2006

Bowen Liu Graduate Student (Interdisciplinary) 2006 Michael Thompson Graduate Student (MD/PhD) 2005-present

Peggy Muller Pathology (Pre-doctoral fellow) 2005-2006


Supervision of medical students

Nicholas Maurice MS-2 (MSTP, UPSOM) 2008 Tracey Proverbs-Singh MS-2 (UPSOM) 2007 Melissa Lee MS-II (UPSOM) 2004

Supervision of residents

Manpreet Kaur Resident (PGY2, Internal Medicine, AGH) 2006-2007 Farrukh, Awan, M.D. Resident (PGY2, Internal Medicine, UPMC) 2005-2006 Sandeep Sekhon, M.D. Internal Medicine (PGY2, AGH, Pittsburgh) 2002-2003

Supervision of post-doctoral fellows (basic)

Zeng Gang, M.D., Ph.D. Pathology (Post-doctoral fellow) 2004-present Xinping Tan, Ph.D. Pathology (Post-doctoral fellow) 2003-2008

Udayan Apte, Ph.D. Pathology (Post-doctoral fellow) 2004-2007 Dimple Sodhi, M.D. Appl. Develop. Psychology (Postdoc) 2003

Supervision of post-doctoral fellows (clinical)

Sunny Hussain, M.D.,Ph.D. Pediatric Gastroenterology (Clinical fellow) 2002

Jaideep Behari, M.D., Ph.D. Gastroenterology (Clinical fellow) 2004-2006 Dulabh K. Monga, M.D. Hematology/Oncology (Clinical fellow) 2002-2003

Funded Laboratory Members (Past/Present) Jaideep Behari, M.D., Ph.D. Assistant. Prof. of Medicine K08 (NIAAA) 07/08-06/13 Michael Thompson GS F30 (NIDDK) 08/08-07/13

CATER T32 predoc fellow Udayan Apte, Ph.D. Assistant Prof. of Toxicology American liver Foundation Kansas University Emily Boyd Biology (SURP) UPCI-sponsored grant


RESEARCH:

GRANTS 1. Current Grant Support –

07/2007-06/2012: National Cancer Institute

Grant No. 1R01CA124414 Role in Project: P.I. Years: 5

SOURCE: NIH, NCI

Funding: Total-$249,665; Direct-$172,323; Indirect-$77,342

Grant Title: Beta-Catenin as a therapeutic target in HCC. The main goal of this proposal is to examine the role of β-catenin in liver cancer as a therapeutic target, utilizing novel in vivo and ex vivo studies and models

01/2004-12/2013: National Institute of Health, NIDDK

Grant Number: 1R01DK62277 Role in Project: P.I. Years: 10

SOURCE: NIH, NIDDK


Grant Title: Role of Wnt/β-catenin In Liver Development

The main goal of this proposal is to examine the role of β-catenin during liver development, liver regeneration using various transgenic and knockout models.

12/1/2006 – 11/30/2011: National Institute of Health, NHLBI

Grant Number: 1P50 HL084932 Role in Project: co-P.I. Years: 5

SOURCE: NIH, NHLBI


Grant Title: Host factors in fungal allergy and fibrosis. Project IV-KGF and Inhibition of Pulmonary Fibrosis The proposal is aimed at identifying the role of KGF in chronic lung diseases such as pulmonary fibrosis. One of the aims is to identify any β-catenin-mediated effects in chronic lung injury model and its interactions with KGF.

2. Prior Grant Support – 09/04-08/07: Roche Pharmaceuticals

Grant Number: PEG157 Role in Project: P.I. Years: 3 SOURCE (Funded): Roche Pharmaceuticals Grant Title: Investigate therapeutic role of Pegylated Interferon & Ribavirin in HCC


The proposal is aimed at identifying the properties of these anti-viral agents on the Wnt/beta-catenin pathway and activity using in-vitro and in-vivo models.

07/03-06/07: American Cancer Society

Grant Number: RSG-03-141-01-CNE Role in Project: P.I. Years: 4 SOURCE (Funded): American Cancer Society

Grant Title: Role of Wnt/β-catenin and HGF in Hepatocarcinogenesis

The main goal of this proposal is to examine the interactions between Hepatocyte growth factor and its receptor c-Met with β-catenin and how these interactions change during liver regeneration, cancer and liver growth.

07/01-06/02: Department of Pathology, University of Pittsburgh Source: Pathology Postdoctoral Research Training Grant Source (PPRTP) Title: Wnt/beta-catenin in LR Years: 1 Percentage of Effort Inclusive: 100% $ Amount: $10,000

SEMINARS AND INVITED LECTURESHIP RELATED TO RESEARCH

1. ‘Hepatic stem cell, liver development and hepatocyte transplant’ 01/2000

Department of Medicine, DMC & H, Ludhiana, Punjab, India.

2. ‘Molecular Mechanisms in Liver Development, Regeneration and 01/2001 Tumorigenesis’. Dept. of Medicine, DMC & H, Ludhiana, Punjab, India. 3. ‘Wnt/Beta-Catenin Signaling in Liver: Role in Growth and Regeneration' 04/2001

Department of Surgery, UTMB, Galveston, Texas.

4. ‘Wnt/Beta-Catenin Signaling in Liver Regeneration and Hepatocyte 05/2001 Cultures'. Department of Molecular Genetics, Ohio State University,

Columbus, Ohio. 5. ‘Wnt/β-Catenin Signaling – Role in Liver Development, Growth and 05/2001

Carcinogenesis’, Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, PA

6. ‘Therapeutic β-catenin inhibition: a novel strategy to control liver growth’ 11/2002 35th Annual Conference of Indian Pharmacological Society, Gwalior, India

7. ‘Therapeutic β-Catenin Inhibition: Role in Regulated and Unregulated Liver 02/2003

Growth’, Molecular Therapeutics, Drug Discovery and Therapeutics (MT/DT) seminar, University of Pittsburgh Cancer Institute, Pittsburgh.


8. ‘Role of β-catenin in Liver Development and Cancer’, UPMC Horizons 03/2003 Health System, Tumor Board Lecture (Continuing Education)

9. ‘Role of Wnt/β-Catenin in Development and Cancer’ Feist-Weiller 09/2003

Cancer Center Seminars, Louisiana State University, Shreveport, LA. 10. Role of Wnt/β-Catenin in Liver development. Environment and 02/2004

Occupational Health Department Seminar, University of Pittsburgh 11. Fetal hepatocytes in Biorectors. Experimental Biology, 2004 meeting 06/2004

ASIP, annual conference, Washington, D.C. 12. Role of Wnt/β-Catenin in Liver development. Dept. of Developmental 06/2004 Biology, University of Bath, England 13. Bioreactors in hepatic failure: From bench to bedside and back, 07/2004 Dayanand Medical College and Hospital, Ludhiana, India 14. Novel molecular targets in Hepatocellular cancer, 07/2004 Dayanand Medical College and Hospital, Ludhiana, India 15. FASEB Summer research conference 2004; Mechanisms of Liver Growth, 09/2004 Development and Disease, Snowmass, Colorado 16. Liver Seminar Series, University of Pittsburgh, SOM 01/2005 17. Beta-catenin in liver growth and development, Texas A&M, Temple, TX, 02/2005 18. Beta-catenin regulation in Liver Physiology and Pathology, University 04/2005

of Pittsburgh, 2nd Annual Pittsburgh Area Ubiquitin-Proteosome meeting. 19. Beta-catenin in Liver growth and development. University of Pittsburgh 08/2005 Cancer Institute, annual retreat, 2005 20. “Beta-catenin in Liver: Doomed if you have, doomed if you don’t!” 09/2005 Digestive Diseases Forum, Baylor College of Medicine, Houston, TX. 21. Beta-catenin in Liver Health and Disease, Science 2005, Spotlight Session- 10/2005 Growth Factors in Health and Disease, University of Pittsburgh, SOM 22. Beta-catenin is critical in normal liver growth and development, 11/2005 AASLD 2005, San Francisco, CA 23. Beta-catenin in Liver Pathobiology 03/2006 ASIP 2006, San Francisco, CA 24. Beta-catenin in Liver growth and development 04/2006 Virginia Commonwealth University, Richmond, VA 25. Beta-Catenin in Liver Development and Cancer 04/2006 University of Louisiana at Monroe, Monroe, LA


26. Beta-catenin in Liver: Doomed if you have, doomed if you don’t! 08/2006 FASEB Summer Research Conference 27. Beta-Catenin in Liver Pathobiology 11/2006 NIAAA, NIH, Bethesda, MD 28. Wnt/β-catenin Signaling Liver: Promises and Perils 01/2007 Department of Ophthalmology, UPMC 29. Novel insights into liver development and growth 03/2007 McGowan Institute of Regenerative Medicine Annual Retreat, Nemacolin 30. WNT’er in Liver: Promises and Perils 05/2007 Albert Einstein College of Medicine, Yeshiva University, NY 31. Wnt/β-catenin signaling in Liver: Promises and Perils 06/2007

Mount Sinai School of Medicine, New York

32. Wnt Signaling in Cancer 06/2007 Liver Cancer Program, Mount Sinai School of Medicine, New York

33. Wnt/β-catenin signaling in Liver Health and Disease 07/2007 Penn State University, Hershey Medical Center 34. Wnt/β-catenin signaling in Liver: Novel Roles, Novel Opportunities 09/2007

Visiting Professor, Digestive Health Center Seminar, Cincinnati Children's Hospital Medical Center

35. Wnt/β-catenin in Liver, Endoderm Club Meeting 09/2007 Cincinnati Children's Hospital Medical Center

36. Novel Mechanisms in Liver Health & Disease 10/2007 Dept of Pathology, University of Pittsburgh

37. Wnt/β-catenin signaling in liver stem cells: Role in Development & Cancer 01/2008 UPCI Basic Research Seminar Series, Hillman Cancer Center, Pittsburgh 38. Beta-catenin in Liver Stem cells and development: A key player in balancing 03/2008

act! McGowan Institute of regenerative Medicine Annual retreat 2008. 39. Wnt/β-catenin signaling in Regenerative and Developmental Biology of the 04/2008

Liver. EB2008, ASIP annual meeting, San Diego, CA.

40. Wnt’er Wonderland in Liver Pathobiology: Implications in Development and 04/2008 Regeneration. Digestive Diseases Seminar, Yale University, SOM

41. Which way the Wnt blows: Stem cells in liver development & regeneration 05/2008 National Cancer Institute, NIH, Bethesda, MD


42. “Liver regeneration” lecture in course entitled ‘Frontiers in Human ES cells’ 06/2008 Woods Hole, Cape Cod, MA 43. “Wnt signaling in Liver: Novel Roles, Novel Opportunities” FASEB Summer 08/2008

Research Conference, Snowmass, CO 44. “Which way the WNT blows: Stem cells in Liver development and cancer” 09/2008 XXIX National Congress, Italian Society of Pathology, Univ of Calabria, Italy 45. “β-Catenin signaling balances proliferation & differentiation in liver growth 09/2008

& development” University of Cagliari, Cagliari, Italy

46. “Liver Stem Cells in Development and Cancer: You WNT some, you lose 10/2008 some”. Science 2008. University of Pittsburgh, SOM

47. “Stem Cell Pathways in Late Liver Development and Adults” AASLD 11/2008 Basic Research Workshop, San Francisco, CA 48. “Wnt/β-catenin signaling in Liver Stem cells: Implications in Development 11/2008 and cancer”, Research Conference, Division of GI, University of Pittsburgh 49. “β-Catenin in Hepatocellular Cancer: Pathological and Treatment 11/2008

Implications”. Department of Biology, Temple University, Philadelphia, PA 50. “Wnt Signaling in Liver Stem cells: Implications in Transplantation and 11/2008

Cancer”, International Liver Congress, EFLD2008, Cairo, Egypt

51. “Hepatic Carcinogenesis: A Wnt/beta-catenin perspective!” 11/2008 International Liver Congress, EFLD2008, Cairo, Egypt

OTHER RESEARCH RELATED ACTIVITIES GRANT REVIEWING: Hepatobiliary Pathophysiology (HBPP) Scientific Review group 2008-2012 Charter Member, National Institute of Health (NIH) Science Operations and Funding Directorate 06/2008 Cancer Research UK Special Emphasis Panel/Scientific Review Group 03/2008 2008/05 ZDK1 GRB-W (M3) meeting, NIH Science & Technology Development Program 08/2007 North Carolina Biotechnology Center ZDK1 GRB-4 (O1) 1 Review Group 07/2007 NIDDK, NIH, Bethesda, MD


ZRG1 DIG-C (02) M Special Emphasis Panel (SEP) 03/2007 NIH Biotechnology and biological sciences research council (BBSRC), 03/2007 United Kingdom Gastrointestinal Cell and Molecular Biology (GCMB) 02/2007 NIH Molecular Oncogenesis. ZRG1 MONC-U (01) (Q) 10/2006 NIH ZRG1 DIG-C (02) M Special Emphasis Panel 06/2006 (CIGP, GCMP, GMPB, HBPP), NIH ZRG1 DIG F (50) Special Emphasis Panel 06/2006 (Bioengineering), NIH Ad-hoc Reviewer, Hepatobiliary Pathophysiology (HBPP) study section, 2004-2007 NIH Technology Foundation STW - Dutch funding agency financed by 2005 Netherlands Organisation for Scientific Research, NOW & Dutch Ministry Special Emphasis Panel-Reviewer- Beta Cell Biology Consortium (BCBC), 2005 NIDDK, NIH, Bethesda, MD, USA Peer review as an external reviewer for the Department of Experimental 2004 Oncology CRO-IRCCS, Aviano National Cancer Institute, Aviano, Italy. University Grants Committee, Research Grants Council of Hong Kong, 2003 Hong Kong, China JOURNAL REFEREEING: Associate Editor – American Journal of Pathology July 2008–2011 Section Editor – Archives of Pathology and Laboratory Medicine (Molecular Pathology) July 2008-2011 Guest Editor: – Organogenesis Apr., May, Jun. issue: 2008 Editorial Board Member: – Hepatology Jan. 2009- – Organogenesis Mar. 2008- – World Journal of Gastroenterology Jan. 2006- – Archives of Pathology and Laboratory Medicine Jul. 2008-


Book Editor: – Molecular Pathology of Liver Diseases To be published in 2010 Springer publishers Ad hoc referee: – Journal of Clinical Investigation – Current Biology – American Journal of Physiology-GI and Liver Physiology – Gastroenterology – Hepatology – American Journal of Pathology – Gut – Stem Cells – Cell Transplantation – Cancer Letters – Expert Opinions in Biological Therapy – Carcinogenesis – Journal of Hepatology – Gynecologic and Obstetric Investigation – Neoplasia – Digestive Diseases and Sciences – Liver International – Journal of Histochemistry and Cytochemistry – Journal of Pathology – Digestive Diseases Science – Expert opinion on biological therapy – Clinical Cancer Research – World Journal of Gastroenterology – FEBS Letters – Human Pathology Lists of Current Research Interests Wnt signal transduction pathway Liver Development Liver Growth Liver Cancer Liver Stem Cells Liver Regeneration Pancreatic Cancer Cell transplantation Cancer stem cells Bioreactor Technologies Alcoholic Liver disease Nonalcoholic Fatty Liver disease (NAFLD and NASH)


SERVICE: NATIONAL Elected Organizer, FASEB summer research conference on 2008-present “Liver growth Development an Disease” Member-Basic Research Committee 2009-present AASLD Program Chair 2008-2010 American Society of Investigative Pathology Long Range Planning Committee 2006-2008 American Society of Investigative Pathology Program Committee Member for the American Society of Investigative 2003-2008 Pathology, (FASEB, Experimental Biology: 2005-2006) UNIVERSITY AND MEDICAL SCHOOL

Member, Transgenic Advisory Committee 2007-present University of Pittsburgh, SOM Director, MIRM Trainee Career Advancement Program 2005-present University of Pittsburgh, SOM Member-Pathology Retreat Organization Committee 2005-present Member-Admissions Committee, Graduate program in 2004-Present Interdisciplinary Biomedical Sciences, University of Pittsburgh, SOM Member-Recruiting Committee, Graduate program in 2004-Present Interdisciplinary Biomedical Sciences, University of Pittsburgh, SOM Member-Trainee Admission and Evaluation Committee, 2003-Present Cellular Approaches to Tissue Engineering/Regeneration (NIH, T32)

Organizer- cancer Stem cell Workshop 2007 University of Pittsburgh Cancer Institute Judge, Clinical fellows presentations at the Annual Pathology 2007 Research Day Judge, Basic fellows presentations at the Annual Pathology 2006, 2008 Research Day Member-Institute Search Committee for McGowan Institute of 2003-2005 Regenerative Medicine (recruiting new faculty at MIRM)


Director, McGowan Institute (of Regenerative Medicine) Graduate 2002-2005 Students Network, (MIGS-Net)

Judge, Postdoctoral fellows presentations at the Annual Pathology 2005 Research Day Team Leader, Cellular Approaches to Tissue Engineering/Regeneration 2003 (CATER) section at the annual MIRM retreat

Judge, Clinical fellows presentations at the Annual Pathology 2003 Research Day

Chairperson, Graduate Student presentations evaluation 2002 at the Annual Pathology Research Day

Member, McGowan Institute of Regenerative Medicine 2001-Present Liver Section

Member, University of Pittsburgh Cancer Institute, 2002-Present Gastrointestinal Oncology Section

Program Coordinator for the Pathology Postdoctoral Research 2001-2005 Training Program (PPRTP)

Steering Committee Member for Cellular Molecular Pathology for 2001-Present the Pathology Postdoctoral Research Training Program (PPRTP)

Judge, Clinical fellows presentations at the Annual Pathology 2001 Research Day

curriculum vitae university of pittsburgh school of ... · pdf filecurriculum vitae university...

Documents