curriculum vitae - unisi.it · 2017-11-13 · curriculum vitae name: fabio fusi date and place of...

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CURRICULUM VITAE

NAME: Fabio Fusi

DATE AND PLACE OF BIRTH: December 25th, 1963, Siena, Italy.

ADDRESS: Via E.S. Piccolomini, 63 - 53100 SIENA - ITALY.

Phone (home): +39-0577-236469

(office): +39-0577-234438

(lab): +39-0577-234455/6

fax: +39-0577-234446

e-mail: [email protected]

MARITAL STATUS: Married

http://www.ionchannels.org/showauthor.php?surname=Fusi&initials=F

http://www.dsv.unisi.it/it/dipartimento/personale-docente/fabio-fusi

EDUCATION:

1982 - High School Diploma (Liceo Scientifico, Siena, Italy).

1991 - Degree in Pharmaceutical Chemistry and Technology (Pharmacy), University of

Siena, Italy, 110/110 cum laude, with experimental thesis: "Antioxidant phenol

derivatives: calcium antagonistic properties and interaction with mitochondrial oxidative

phosphorylation".

1995 - Ph.D. in Pharmaceutical Sciences, with a Scholarship from the Italian Ministry of

the University and the Scientific Research (MURST), in the Institute of Pharmacological

Sciences, University of Siena, Italy.

English: written, read (7 years).

RESEARCH EXPERIENCE:

1989-present - Institute of Pharmacological Sciences, Department of Biomedical Sciences,

Department of Neurosciences, Department of Life Sciences, University of Siena, Italy. Prof.

G. Sgaragli's laboratory. Experimental research on novel natural as well synthetic modulators

of ionic currents in smooth muscle cells (patch-clamp technique), in vitro antioxidant

properties of some phenol derivatives, cyclooxygenase activity of hemoglobin and

peroxidases, interaction of taurine and related compounds with mitochondrial oxidative

phosphorylation.

FELLOWSHIPS ABROAD:

Oct./Dec. 1989 - Department of Biochemistry, Trinity College, Dublin, Ireland. Dr. T.

Mantle's laboratory. Studies on biochemical enzymology. ERASMUS Fellowship (ICP-

89-I-0062, EU).

Nov. 1990/Jan. 1991 - Department of Biochemistry, Trinity College, Dublin, Ireland. Dr.

M.P. Murphy's laboratory. Studies of the interaction of antioxidant phenol derivatives

http://www.ionchannels.org/showauthor.php?surname=Fusi&initials=F

http://www.dsv.unisi.it/it/dipartimento/personale-docente/fabio-fusi

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with mitochondrial oxidative phosphorylation. ERASMUS Fellowship (ICP-90-I-0072/12,

EU).

Feb./Apr. 1993 - Institute of Physiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.

Prof. K.K. Boev's laboratory. Studies on the interaction of some antioxidant phenol

derivatives with smooth muscle cells. TEMPUS Fellowship (JEP-0789-92/93 EU).

Nov. 1993/May 1994 - Research Associate at the Department of Pharmacology, School of

Medicine, Southern Illinois University, Springfield, IL, USA. Prof. E. Giacobini's

laboratory. Studies on CNS concerning the development of new drugs for the treatment of

patients affected by Alzheimer's disease.

Mar./Sep. 1995 - Research Associate at the Department of Pharmacology, University of

Cambridge, U.K. Dr. B.A. Callingham's laboratory. Studies on semicarbazide-sensitive

amino oxidases in deer digital artery and mesanglial cell; studies on adenosine receptors

in guinea pig aorta.

FELLOWSHIPS IN ITALY:

May/Oct. 1991 - Convention with the Department of historical-social and philosophic

studies, University of Siena, Italy.

Feb./Mar. 1995 - Research Associate in the Institute of Pharmacological Sciences,

University of Siena, Italy.

Nov. 1995 - Contract at the Institute of Pharmacological Sciences, University of Siena,

Italy.

Jan./Mar. 1996 - Research Associate at the Institute of Pharmacological Sciences,

University of Siena, Italy. Project BIOMED I (Eurotaurine: regulation and function of

taurine in the mammalian central nervous system. BMH1-CT94-1402).

Apr. 1996/Mar. 1998 - Research Fellowship from the University of Siena.

Aug 1997/Gen. 1999 - Technical assistant in the Institute of Pharmacological Sciences,

University of Siena, Italy, under the joint project Italy-Bulgaria entitled “Chemical and

physiopathological relationships in cerebral ischaemia: development of new therapeutic

strategies”.

Feb. 1999 - Oct. 2002"Assegno di Ricerca per l'Area Scientifica Farmacologica" (D.R. n.

449 del 21-7-1998) in the Institute of Pharmacological Sciences, University of Siena,

Italy.

Feb. 2001 - Department of Neuroscience, Physiology Section, University of Turin, Italy.

Prof. E. Carbone's laboratory. Studies on Ca2+

currents (single channel) with the patch-

clamp technique in smooth muscle as well as neuroendocrine cells.

Nov. 2002 – Researcher at the University of Siena, Italy.

HONOURS:

Dic. 1996 - Member of the Italian Pharmacological Society.

Nov. 1997 - Qualified as Technical assistant - VII qualification (D.R. n.362, 29.4.1997 -

G.U. n.39 (4° serie speciale) 20.5.1997).

Nov. 2004 - Dec. 2012 – Member of Comitato per la Didattica del Corso di Laurea in

Chimica e Tecnologia Farmaceutiche, LM e LS.

Referee for Biochemical Pharmacology, Journal of Pharmacological Sciences,

Pharmacological Research, Pharmacology, Journal of Pharmacy and Pharmacology, Life

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Sciences, Phytotherapy Research, Journal of Ethnopharmacology, Planta Medica, Journal

of Medicinal Food.

Jun. 2015 – Member of the Pharmacology Research & Perspectives Editorial Board

(Wiley).

INVITED LECTURES:

Jun. 2012 - The Hyacinthaceae: Chemistry, Pharmacology, Taxonomy and Ethnobotany. An

International, Multidisciplinary Symposium. 14th June - 15th June 2012, University of

Surrey, Guildford, United Kingdom.

TEACHING:

Oct. 1993 - Lecturer at the "Training Course in Biochemical Pharmacology", Certosa di

Pontignano, Siena, Italy (COMETT Programme, EU).

May 1999 - Lecturer at the "Recent advances in Neurobiology", Istituto di Scienze

Farmacologiche, University of Siena, Italy (Programme SOCRATES, European Union).

2000/2001: - Module "Farmacologia dei Canali Ionici" (n.° 6 ore) (Course: Farmacologia

e Farmacoterapia I; Degree in Pharmacy).

2001/2002: - Module "Farmacologia dei Canali Ionici" (n.° 10 ore) (Course: Farmacologia

e Farmacoterapia I; Degree in Pharmacy).

2001/2002: - Module "Standardizzazione Biologica dei Farmaci" (n.° 10 ore) (Course:

Farmacologia e Farmacoterapia I; Degree in Pharmacy).

2002/2003: - Statistica applicata alla ricerca biomedica (Course: Esercitazioni di statistica;

Degree in Tecniche erboristiche, Farmacia, Controllo di qualità nel settore industriale

farmaceutico, Scienza e tecnologia dei prodotti cosmetici).

2004: - Lecturer at the Training course “Terapia convenzionale e nuove classi di farmaci

nel trattamento dell’ipertensione”, Sala Euclide, Matera, Italy, March 13-14, 2004.

2007-2010: - Principi di statistica e interpretazione scientifica dell’analisi statistica (Ph.D.

school in Physiology, pharmacology, molecular and cellular toxicology).

2003/present: - Saggi e Dosaggi Farmacologici (Corso di Laurea in Chimica e Tecnologia

Farmaceutiche);

2003/present: - Statistica Medica (Master Avanzato di II livello in Scienza e Tecnologia

Cosmetiche).

SUPERVISION OF Ph.D. STUDENTS

Jan. 2007 - Dr. Donata Iozzi (Doctor europæus), Doctorate in physiology, pharmacology,

molecular and cellular toxicology, XIX cycle. Title: Analysis of the mechanisms

underlying the vasorelaxant action of two natural related flavonoids: quercetin and (+/-)-

naringenin.

Feb. 2008 - Dr.ssa Caterina Lacava (Doctor europæus), Doctorate in physiology,

pharmacology, molecular and cellular toxicology, XX cycle. Title: Pharmacological

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profile of 3,5-di-t-butylcatechol in the mammalian skeletal muscle and its use in the

diagnosis of malignant hyperthermia.

Feb. 2009 - Dr.ssa Antonella Ferrara, Doctorate in physiology, pharmacology, molecular

and cellular toxicology, XXI cycle. Title: Effect of de-alcoholated red wine in isolated rat

heart: protective action in myocardial ischemia-reperfusion injury.

Nov. 2012 - Dr. Paolo Mugnai, Doctorate in physiology, pharmacology, molecular and

cellular toxicology, XXV cycle. Title: The flavonoid quercetin stimulates the vascular

smooth muscle Cav1.2 current: new insight into its mechanism of action.

Nov. 2013 - Dr.ssa Miriam Durante, Doctorate in physiology, pharmacology, molecular

and cellular toxicology, XXVI cycle. Provisional title: Studio dei potenziali effetti

vascolari di estratti di piante medicinali vietnamite.

EXTERNAL EXAMINER

Dec. 2012 - PhD Thesis entitled “The extractives from Sophora Velutina and Calpurnia

Aurea and their biological activity“ by Erick Kipkoech Korir, University of KwaZulu-

Natal, South Africa.

Dec. 2012 - PhD Thesis entitled “Synthesis and biological evaluation of fluorinated

derivatives of 2-styrylchromones and 2-thioxo imidazole dicarboxylate esters “ by Mehbb

I Khail Momin, University of KwaZulu-Natal, South Africa.

Feb. 2014 - PhD Thesis entitled “Phytochemistry and bioactive natural products from

Lannea Alata, Lannea Rivae, Lannea Shimperi and Lannea Schweinfurthii

(Anacardiaceae)“ by Okoth Akinyi Dorothy, University of KwaZulu-Natal, South Africa.

Dec. 2015 - PhD Thesis entitled “Synthesis and biological studies of novel

pyranochromene derivatives“ by Sunayna Sachin Pawar, University of KwaZulu-Natal,

South Africa.

RESEARCH PROJECT FUNDED

Agency: Italian Ministry of Foreign Affairs - Executive programme of scientific and

technological co-operation between Italy and South Africa. Period: 2005-2007. Title:

"Investigations of isolates from the Hyacinthaceae family for cardiovascular activity".

Principal investigators: Dr. Fabio Fusi, Ph.D., and Prof. Dulcie Mulholland, University of

KwaZulu-Natal, South Africa.

For the exchange of researchers

Agency: Italian Ministry of Foreign Affairs - Significant research projects selected within the

frame of the IV Executive programme of scientific and technological co-operation between

Italy and Vietnam. Period: 2009-2011. Title: "Discovery of novel cardiovascular active agents

from selected Vietnamese medicinal plants ". Principal investigators: Dr. Fabio Fusi e Dr.

Nguyen Manh Cuong, Hanoi University of Pharmacy, Vietnam.

Year 2010: € 35.000.

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Year 2011: € 30.000.

Agency: Italian Ministry of Foreign Affairs - Significant research projects selected within the

frame of the II Executive programme of scientific and technological co-operation between

Italy and Slovakia. Period: 2009-2011. Title: "Molecular mechanisms underlying the

cardiovascular and neuronal protective effects of a flavonoid-rich diet". Principal

investigators: Dr. Fabio Fusi e Dr. Lubica Lacinova, Slovak Academy of Sciences, Institute

for Molecular Physiology and Genetics, Slovakia.

Contract for research project with Rottapharm S.p.A.. Title: “Effect of Andolast on KCa3.1

currents in RBL-2H3 cells”.

Year 2010: € 5.500.

COURSES:

June 15, 1992 - Mini Course on "Reactive species in vascular injury", Prof. Bruce A.

Freeman, Institute "Mario Negri", Milan, Italy.

Sept. 5-9, 1994 - XIV Advanced Course in Pharmaceutical Chemistry: i) "Cerebral ischemia:

new therapeutical approaches"; ii) "Carbohydrates: glycotecnologies and drug design".

University of Urbino, Italy.

Ph.D. THESIS

Derivati fenolici di origine naturale o sintetici con proprietà antiossidanti e

calcioantagonistiche come farmaci per la prevenzione dei danni tessutali da ischemia-

riperfusione

PUBLICATIONS

1) Fusi F., Valoti M., Sgaragli G.P. and Murphy M.P. (1991). The interaction of antioxidants

and structurally related compounds with mitochondrial oxidative phosphorylation. Methods

Find. Exp. Clin. Pharmacol., 13 (9), 599-603. (I.F. 0.577)

2) Fusi F., Sgaragli G.P. and Murphy M.P. (1992). Interaction of butylated hydroxyanisole

with mitochondrial oxidative phosphorylation. Biochem. Pharmacol., 43 (6), 1203-1208.

(I.F. 2.129)

3) Sgaragli G.P., Valoti M., Fusi F., Palmi M., Mantovani P., De Santi M.M., Lorenzini L.

and Tosi P. (1993). Toxic injury to rat gut musculature following intraperitoneal

administration of 2-t-butyl-4-methoxyphenol. Eur. J. Pharmacol., 248, 121-129.

(I.F. 2.849)

4) Sgaragli G.P., Valoti M., Gorelli B., Fusi F., Palmi M. and Mantovani P. (1993). Calcium

antagonist and antiperoxidant properties of some hindered phenols. Br. J. Pharmacol., 110,

369-377. (I.F. 5.270)

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5) Zilletti L., Ciuffi M., Franchi-Micheli S., Fusi F., Gentilini G., Moneti G., Valoti M. and

Sgaragli G.P. (1994). Cyclooxygenase activity of hemoglobin. Methods Enzym., 231, 562-

573. Hemoglobins, Part B. J. Everse Eds., Academic Press. (I.F. 1.545)

6) Silvestri R., Pagnozzi E., Valoti M. and Fusi F. (1994). Non-steroidal antiinflammatory

agents. Synthesis and enzyme inhibition of 2-[4-(heteroarylmethyl)phenil] propanoic acids

and analogues. Il Farmaco, 49 (10), 625-632. (I.F. 0.346)

7) Mori F., Lai C., Fusi F. and Giacobini E. (1995). Cholinesterase inhibitors increase

secretion of APPs in rat brain cortex. NeuroReport, 6, 633-636. (I.F. 2.570)

8) Petkov G., Fusi F., and Boev K.K. (1995). Effects of cyclopiazonic acid on the phasic and

tonic contractions in the smooth muscles of the guinea-pig and cat stomach. Compt. Rend.

Bulg. Acad. Sci., 48 (8), 57-60.

9) Palmi M., Fusi F., Youmbi G., Frosini M., Bianchi L., Della Corte L., Sgaragli G.P. and

Tipton K.F. (1996). Effects of taurine and structurally-related analogues on Ca2+-uptake and

respiration rate in rat liver mitochondria. Adv. Exp. Med. Biol., 403, 117-124.

(I.F. 0.446)

10) Fusi F., Marazova K., Pessina F., Petri C. and Sgaragli G.P. (1997). Can food

antioxidants prevent cancer and cardiovascular diseases? Acta Phytotherapeutica, 3, 10-20.

11) Palmi M., Youmbi G., Fusi F., Frosini M., Sgaragli G.P., Della Corte L., Bianchi L. and

Tipton K.F. (1998). Antagonism by taurine on the ruthenium red-induced and 6-

hydroxydopamine plus 1-methyl-4-phenylpyridinium-induced Ca2+ release from rat liver

mitochondria. Adv. Exp. Med. Biol., 442, 91-98. (I.F. 0.446)

12) Fusi F., Gorelli B., Valoti M., Marazova K. and Sgaragli G.P. (1998). Effects of 2,5-di-t-

butyl-1,4-benzohydroquinone (BHQ) on rat aorta smooth muscle. Eur. J. Pharmacol., 346,

237-243. (I.F. 1.992)

13) Fusi F., Valoti M., Petkov G., Boev K.K. and Sgaragli G.P. (1998). Myorelaxant activity

of 2-t-butyl-4-methoxyphenol (BHA) in guinea pig gastric fundus. Eur. J. Pharmacol., 360,

43-50. (I.F. 1.992)

14) Fusi F., Valoti M., Frosini F. and Sgaragli G.P. (1999). 2,5-Di-t-butyl-1,4-

benzohydroquinone induces endothelium-dependent relaxation of rat thoracic aorta. Eur. J.

Pharmacol., 366, 181-187. (I.F. 2.047)

15) Frosini M., Sesti C., Valoti M., Palmi M., Fusi F., Parente L. and Sgaragli G. (1999).

Rectal temperature and prostaglandin E2 increase in cerebrospinal fluid of conscious rabbits

after intracerebroventricular injection of hemoglobin. Exp. Brain Res., 126, 252-258.

(I.F. 2.246)

16) Palmi M., Youmbi G., Fusi F., Sgaragli G.P., Dixon H.B.F., Frosini M. and Tipton K.F.

(1999). Potentiation of mitochondrial Ca2+ sequestration by taurine. Biochem. Pharmacol.,

58, 1123-1131. (I.F. 2.755)

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17) Palmi M., Tchuisseu Youmbi G., Sgaragli G.P., Meini A., Benocci A., Fusi F., Frosini

M., Della Corte L., Davey G. and Tipton K.F. (2000). The mitochondrial permeability

transition and taurine. Adv. Exp. Med. Biol., 483, 87-96. (I.F. 0.513)

18) Frosini M., Sesti C., Palmi M., Valoti M., Fusi F., Mantovani P., Bianchi L., Della Corte

L. and Sgaragli G.P. (2000). The possible role of taurine and GABA as endogenous cryogens

in the rabbit. Adv. Exp. Med. Biol., 483, 335-344. (I.F. 0.513)

19) Valoti M., Fusi F., Frosini M., Pessina F., Tipton K.F. and Sgaragli G.P. (2000).

Cytochrome P450-dependent N-dealkylation of l-deprenyl in C57BL mouse liver

microsomes: effects of in vivo pretreatment with ethanol, phenobarbital, -naphthoflavone

and l-deprenyl. Eur. J. Pharmacol., 391, 199-206. (I.F. 2.236)

20) Fusi F., Marazova K., Pessina F., Gorelli B., Valoti M., Frosini M. and Sgaragli G.P.

(2000). On the mechanisms of the antispasmodic action of some hindered phenols in rat aorta

rings. Eur. J. Pharmacol., 394, 109-115. (I.F. 2.236)

21) Frosini M., Sesti C., Palmi M., Valoti M., Fusi F., Mantovani P., Bianchi L., Della Corte

L. and Sgaragli G. (2000). Heat-stress-induced hyperthermia alters CSF osmolality and

composition in conscious rabbits. Am. J. Physiol. (Regul. Integr. Comp. Physiol.), 279,

R2095-R2103. (I.F. 2.765)

22) Fusi F., Saponara S., Gagov H. and Sgaragli G.P. (2001). Effects of some sterically

hindered phenols on whole-cell Ca2+

current of guinea pig gastric fundus smooth muscle cells.

Br. J. Pharmacol., 132, 1326-1332. (I.F. 3.502)

23) Fusi F., Saponara S., Gagov H. and Sgaragli G.P. (2001). 2,5-Di-t-butyl-1,4-

benzohydroquinone (BHQ) inhibits vascular L-type Ca2+

channel via superoxide anion

generation. Br. J. Pharmacol., 133, 988-996. (I.F. 3.502)

24) Pessina F., Kalfin R., Esposito L., Fusi F., Valoti M., Ponticelli F. and Sgaragli G.

(2001). Neuroprotection afforded by some hindered phenols and -tocopherol in guinea-pig

detrusor strips subjected to anoxia-glucopenia and reperfusion-like conditions. Naunyn

Schmiedeberg's Arch. Pharmacol., 364, 462-471. (I.F. 2.472)

25) Petkov G.V., Fusi F., Saponara S., Gagov H., Sgaragli G.P. and Boev K.K. (2001).

Characterization of voltage-gated calcium currents in freshly isolated smooth muscle cells

from rat tail main artery. Acta Physiol. Scand., 173, 257-265. (I.F. 1.660)

26) Fusi F., Tzankova V., Valoti M., Pessina F. and Sgaragli G.P. (2001). 3,5-Di-t-butyl-4-

hydroxyanisole (DTBHA) activation of rat skeletal muscle sarcoplasmic reticulum Ca2+

-

ATPase. Biochem. Pharmacol., 62, 1613-1619. (I.F. 3.340)

27) Saponara S., Sgaragli G. and Fusi F. (2002). Quercetin as a novel activator of L-type Ca2+

channels in rat tail artery smooth muscle cells. Br. J. Pharmacol., 135, 1819-1827.

(I.F. 3.45)

28) Fusi F., Saponara S., Sgaragli G., Cargnelli G. and Bova S. (2002). Ca2+

entry blocking

and contractility promoting actions of norbormide in single rat caudal artery myocytes. Br. J.

Pharmacol., 137, 323-328. (I.F. 3.45)

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29) Fusi F., Saponara S., Pessina F., Gorelli B. and Sgaragli G. (2003). Effects of quercetin

and rutin on vascular preparations. A comparison between mechanical and

electrophysiological phenomena. Eur. J. Nutr., 42, 10-17. (I.F. 1.684)

30) Bova S., Cavalli M., Cima L., Luciani S., Saponara S., Sgaragli G., Cargnelli G. and Fusi

F. (2003). Relaxant and Ca2+

channel blocking properties of norbormide on rat non-vascular

smooth muscles. Eur. J. Pharmacol., 470, 185-191. (I.F. 2.352)

31) Valoti M., Frosini M., Dragoni S., Fusi F., and Sgaragli G.P. (2003). Pharmacokinetics of

diphenhydramine in healthy volunteers with a dimenhydrinate 25 mg chewing gum

formulation. Methods Find. Exp. Clin. Pharmacol., 25, 377-381. (I.F. 0.456)

32) Fusi F., Saponara S., Frosini M., Gorelli B. and Sgaragli G. (2003). L-type Ca2+

channels

activation and contraction elicited by myricetin on vascular smooth muscles. Naunyn

Schmiedeberg's Arch. Pharmacol., 368, 470-478. (I.F. 2.101)

33) Saponara S., Kawase M., Shah A., Motohashi N., Molnar J., Ugocsai K., Sgaragli G. and

Fusi F. (2004). 3,5-Dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7)

as a new multidrug resistance reverting agent devoid of effects on vascular smooth muscle

contractility. Br. J. Pharmacol., 141, 415-422. (I.F. 3.325)

34) Fusi F., Iozzi D., Sgaragli G. and Frosini M. (2005). 3,5-Di-t-butylcatechol (DTCAT) as

an activator of rat skeletal muscle ryanodine receptor Ca2+

channel (RyRC). Biochem.

Pharmacol., 69, 485-491. (I.F. 3.617)

35) Fusi F., Sgaragli G. and Saponara S. (2005). Mechanism of myricetin stimulation of

vascular L-type Ca2+

current. J. Pharmacol. Exp. Ther., 313, 790-797.

(I.F. 4.098)

36) Fusi F., Saponara S., Valoti M., Dragoni S., D’Elia P., Sgaragli T., Alderighi D., Kawase

M., Shah A., Motohashi N. and Sgaragli G. (2006). Cancer cell permeability-glycoprotein as a

target of MDR reverters: possible role of novel dihydropyridine derivatives. Curr. Drug

Targets, 7, 949-959. (I.F. 4.274)

37) Carosati E., Cruciani G., Chiarini A., Budriesi R., Ioan P., Spisani R., Spinelli D.,

Cosimelli B., Fusi F., Frosini M., Matucci R., Gasparrini F., Ciogli A., Stephens P.J. and

Devlin F.J. (2006). Calcium channel antagonists discovered by a multidisciplinary approach.

J. Med. Chem., 49, 5206-5216. (I.F. 5.115)

38) Saponara S., Testai L., Iozzi D., Martinotti E., Martelli A., Chericoni S., Sgaragli G., Fusi

F. and Calderone V. (2006). (+/-)-Naringenin as large conductance Ca2+

-activated K+ (BKCa)

channel opener in vascular smooth muscle cells. Br. J. Pharmacol., 149, 1013-1021.

(I.F. 3.825)

39) Fusi F., Ferrara A., Sgaragli G. and Saponara S. (2007). Mechanisms of the

antispasmodic activity of 3,5-di-t-butyl catechol (DTCAT) on rat vascular smooth muscles.

Eur. J. Pharmacol., 561, 112-120. (I.F. 2.376)

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40) Saponara S., Ferrara A., Gorelli B., Shah A., Kawase M., Sgaragli G. and Fusi F. (2007).

3,5-Dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7): a new

multidrug resistance inhibitor devoid of effect on Langendorff-perfused rat heart. Eur. J.

Pharmacol., 563, 160-163. (I.F. 2.376)

41) Fusi F., Ferrara A., Zalatnai A., Molnar J., Sgaragli G. and Saponara S. (2008). Vascular

activity of two silicon compounds, ALIS 409 and ALIS 421, novel multidrug-resistance

reverting agents in cancer cells. Cancer Chemother. Pharmacol., 61, 443-451.

(I.F. 2.740)

42) Fusi F., Ferrara A., Koorbanally C., Crouch N.R., Mulholland D.A. and Sgaragli G.

(2008). Vascular myorelaxing activity of isolates from South African Hyacinthaceae partly

mediated by activation of soluble guanylyl cyclase. J. Pharm. Pharmacol., 60, 489-497.

(I.F. 1.847)

43) Carosati E., Budriesi R., Ioan P., Ugenti M.P., Frosini M., Fusi F., Corda G., Cosimelli

B., Spinelli D., Chiarini A. and Cruciani G. (2008). Discovery of novel and cardioselective

diltiazem-like calcium channel blockers via virtual screening. J. Med. Chem., 51, 5552-5565.

(I.F. 4.898)

44) Saponara S., Sgaragli G. and Fusi F. (2008). Quercetin antagonism of Bay K 8644 effects

on rat tail artery L-type Ca2+

channels. Eur. J. Pharmacol., 598, 75-80.

(I.F. 2.787)

45) Bova S., Saponara S., Rampa A., Gobbi S., Cima L., Fusi F., Sgaragli G., Cavalli M., De

los Rios C., Striessnig J. and Bisi A. (2009). Anthracene based compounds as new L-type

Ca2+

channel blockers: design, synthesis, and full biological profile. J. Med. Chem., 52, 1259-

1262. (I.F. 4.802)

46) Budriesi R., Cosimelli B., Ioan P., Ugenti M.P., Carosati E., Frosini M., Fusi F.,

Saponara, S., Cruciani G., Novellino E., Spinelli D. and Chiarini A. (2009). L-Type calcium

channel blockers: from diltiazem to 1,2,4-oxadiazol-5-ones via thiazinooxadiazol-3-one

derivatives. J. Med. Chem., 52, 2352-2362. (I.F. 4.802)

47) Carosati E., Budriesi R., Ioan P., Cruciani G., Fusi F., Frosini M., Saponara S., Gasparrini

F., Ciogli A., Villani C., Stephens P.J., Devlin F.J., Spinelli D. and Chiarini A. (2009).

Stereoselective behavior of the functional diltiazem analogue 1-[(4-chlorophenyl)sulfonyl]-2-

(2-thienyl)pyrrolidine, a new L-type calcium channel blocker. J. Med. Chem., 52, 6637-6648.

(I.F. 4.802)

48) Fusi F., Cavalli M., Mulholland D., Crouch N.R., Coombes P., Dawson G., Bova S.,

Sgaragli G. and Saponara S. (2010). Cardamonin is a bifunctional vasodilator that inhibits

Cav1.2 current and stimulates KCa1.1 current in rat tail artery myocytes. J. Pharmacol. Exp.

Ther., 332, 531-540. (I.F. 4.017)

49) Saponara S., Carosati E., Mugnai P., Sgaragli G. and Fusi F. (2011). The flavonoid

scaffold as a template for the design of modulators of the vascular Cav1.2 channels. Br. J.

Pharmacol., 164, 1684-1697. (I.F. 4.409)

50) Saponara S., Gorelli B., Tzankova V., Martelli C., Teodori·E., Sgaragli G. and Fusi F.

1

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(2011). The novel potent multidrug resistance inhibitors N,N-bis(cyclohexanol)amine aryl

esters are devoid of vascular effects. Pharmacology, 88, 137-141. (I.F. 1.788)

51) Lacava C., Sgaragli G. and Fusi F. (2012). 3,5-Di-t-butylcatechol as a ryanodine receptor

agonist in rat intact skeletal muscle fibers. Drug Dev. Res., 73, 138-145.

(I.F. 0.869)

52) Fusi F., Sgaragli G., Ha L.M., Cuong N.M. and Saponara S. (2012). Mechanism of

osthole inhibition of vascular Cav1.2 current. Eur. J. Pharmacol., 680, 22-27.

(I.F. 2.592)

53) Lacava C., Michalek-Sauberer A., Kraft B., Sgaragli G., Sipos E., Höller C., Kress H.G.,

Fusi F. and Weigl L.G. (2012). 3,5-Di-t-butyl catechol is a potent human ryanodine receptor

1 activator, not suitable for the diagnosis of malignant hyperthermia susceptibility.

Pharmacol. Res., 66, 80-87. (I.F. 4.346)

54) Saponara S., Fusi F., Sgaragli G., Cavalli M., Hopkins B. and Bova S. (2012). Effects of

commonly used protein kinase inhibitors on vascular contraction and L-type Ca2+

current.

Biochem. Pharmacol., 84, 1055-1061. (I.F. 4.576)

55) Durante M., Sgaragli G., Biasutto L., Mattarei A. and Fusi F. (2013). Quercetin

mitochondriotropic derivatives antagonize nitrate tolerance and endothelial dysfunction of

isolated rat aorta rings. Planta Med., 79, 465-467. (I.F. 2.339)

56) Iozzi D., Schubert R., Kalenchuk V.U., Neri A., Sgaragli G., Fusi F. and Saponara S.

(2013). Quercetin relaxes rat tail main artery partly via a PKG-mediated stimulation of KCa1.1

channels. Acta Physiol., 208, 329-339. (I.F. 4.251)

57) Fusi F., Durante M., Sgaragli G., Cuong N.M., Dung P.T.P. and Nam N.H. (2013). 2-

Aryl- and 2-amido-benzothiazoles as multifunctional vasodilators on rat artery preparations.

Eur. J. Pharmacol., 714, 178-187. (I.F. 2.684)

58) Ferrara A., Fusi F., Gorelli B., Sgaragli G. and Saponara S. (2014). Freeze-dried red wine

effects on cardiac function and ECG of the Langendorff-perfused rat heart. Can. J. Physiol.

Pharm., 92, 171-174. (I.F. 1.770)

59) Cuong N.M., Khanh P.N., Duc H.V., Huong T.T., Tai B.H., Binh N.Q., Durante M. and

Fusi F. (2014). Vasorelaxing activity of two coumarins from Murraya paniculata leaves.

Biol. Pharm. Bull., 37, 694-697. (I.F. 1.828)

60) Mugnai P., Durante M., Sgaragli G., Saponara S., Paliuri G., Bova S. and Fusi F. (2014).

L-type Ca2+

channel current characteristics are preserved in rat tail artery myocytes after one-

day storage. Acta Physiol., 211, 334-345. (I.F. 4.382)

61) Cuong N.M., Khanh P.N., Huyen P.T., Duc H.V., Huong T.T., Ha V.T., Durante M.,

Sgaragli G. and Fusi F. (2014). Vascular L-type Ca2+

channel blocking activity of sulphur-

containing indole alkaloids from Glycosmis petelotii. J. Nat. Prod., 77, 1586-1593.

(I.F. 3.798)

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62) Spinelli D., Budriesi R., Cosimelli B., Severi E., Micucci M., Baroni M., Fusi F., Ioan P.,

Cross S., Frosini M., Saponara S., Matucci R., Rosano C., Viale M., Chiarini A. and Carosati

E. (2014). Playing with opening and closing of heterocycles: using the Cusmano-Ruccia

reaction to develop a novel class of oxadiazolothiazinones, active as calcium channel

modulators and p-glycoprotein inhibitors. Molecules, 19, 16543-16572.

(I.F. 2.416)

63) Fusi F. and Sgaragli G. (2015). Reversion of nitrate tolerance in rat aorta rings by freeze-

dried red wine. Phytother. Res., 29,628-631. (I.F. 2.660)

64) Fusi F., Durante M., Sgaragli G., Khanh P.N., Son N.T., Huong T.T., Huong N.V. and

Cuong N.M. (2015). In vitro vasoactivity of zerumbone from Zingiber zerumbet. Planta Med.,

81, 298-304. (I.F. 2.152)

65) Saponara S., Durante M., Spiga O., Mugnai P., Sgaragli G., Huong T.T., Khanh P.N., Son

N.T., Cuong N.M. and Fusi F. (2016). Functional, electrophysiological and molecular

docking analysis of the modulation of Cav1.2 channels in rat vascular myocytes by

murrayafoline A. Br. J. Pharmacol., 173, 292-304. (I.F. 4.842)

66) Fusi F., Manetti F., Durante M., Sgaragli G. and Saponara S. (2016). The vasodilator

papaverine stimulates L-type Ca2+

current in rat tail artery myocytes via a PKA-dependent

mechanism. Vascul. Pharmacol., 76, 53-61. (I.F. 3.635)

67) Carosati E., Cosimelli B., Ioan P., Severi E., Katneni K., Chiu F.C.K., Saponara S., Fusi

F., Frosini M., Matucci R., Micucci M., Chiarini A., Spinelli D. and Budriesi R. (2016).

Understanding oxadiazolothiazinone biological properties: negative inotropic activity versus

cytochrome p450-mediated metabolism. J. Med. Chem., in press. (I.F. 5.447)

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CHAPTERS OF BOOKS

1) Sgaragli G.P., Fusi F. and Gorelli B. (1993). Methods of investigation of calcium

metabolism in smooth muscle cells. Training Course in Biochemical Pharmacology, Book of

the Course.

2) Benocci A., Frosini M., Fusi F., Gorelli B., Marazova K. and Sgaragli G.P. Current

methods for studying cell calcium (1997). Biochemical Pharmacological Techniques:

Theoretical & Experimental Aspects. Book of the Course.

3) Fusi F., Saponara S., Gagov H. and Sgaragli G.P. (1999). The patch-clamp technique:

development and uses to investigate Ca2+

currents. Gli Atti dell'Accademia delle Scienze di

Siena detta de' Fisiocritici, serie XV, tomo XVIII, 89-99.

4) Valoti M., Fusi F. and Sgaragli G.P. (2001). Phenolic antioxidants with calcium antagonist

properties: the need for novel, more specific food antioxidant. Fair Conference on Food

Antioxidants and Human Health. Ed. Sgaragli G.P. and Valoti M. pp. 57-67.

5) Fusi F., Saponara S., Pessina F., Gorelli B. and Sgaragli G.P. (2002). Effects of wine

polyphenols on vascular functions: an electro-mechanic investigation. Bioactive Compounds

in Plant Foods. Health Effects and Perspectives for the Food Industry. Ed. Amadò R., Abt B.,

Bravo L., Goñi I. And Saura-Calixto F. pp. 108-109.

6) Fusi F., Saponara S. and Sgaragli G.P. (2004). Effetto della quercetina e di alcuni

flavonoidi ad essa strutturalmente correlati, sulle correnti di Ca2+

di tipo L in cellule muscolari

lisce isolate dall’arteria principale della coda di ratto. Annali piante officinali, vol. 8, pp. 46-

47.

ABSTRACTS

1) Fusi F., Valoti M., Gorelli B., Mantovani P. and Sgaragli G.P. (1992). Calcium antagonist

properties on rat ileum longitudinal muscle of 2-t-butyl-4-methoxyphenol (BHA). Pharmacol.

Res., 26 (suppl. 1), 322.

2) Zilletti L., Gentilini M.G., Franchi-Micheli S., Mugnai S., Ciuffi M., Valoti M., Moneti G.,

Fusi F. and Sgaragli G.P. (1992). Cyclooxygenase activity of haemoglobin: a comparative

study in different species. Pharmacol. Res., 26 (suppl. 1), 266.

3) Valoti M., Fusi F., Gorelli B., Palmi M. and Sgaragli G.P. (1993). Nifedipine-like

properties in normal and skinned ileum longitudinal muscle in rat and antiperoxidant activities

of some hindered phenols. Pharmacol. Res., 27 (suppl. 1), 69-70.

4) Fusi F., Valoti M., Petkov G., Boev K.K. and Sgaragli G.P. (1994). Effects of 2-t-butyl-4-

methoxyphenol (BHA) on plasmalemma and intracellular Ca2+ transport in guinea pig gastric

fundus smooth muscle. Br. J. Pharmacol., 111, 251P.

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5) Zilletti L., Ciuffi M., Franchi-Micheli S., Fusi F., Gentilini G., Mugnai S., Valoti M. and

Sgaragli G.P. (1994). Metabolism of arachidonate catalysed by haemoglobin. Br. J.

Pharmacol., 111, 73P.

6) Zilletti L., Ciuffi M., Franchi-Micheli S., Fusi F., Gentilini G., Moneti G., Valoti M.,

Mugnai S. and Sgaragli G.P. (1994). Metabolism of arachidonic acid catalysed by

haemoglobin. Pharmacol. Res., 30 (4), 347.

7) Valoti M., Fusi F. and Sgaragli G.P. (1994). Free radicals inactivation by some antioxidant

hindered phenols in biological systems. Pharmacol. Res., 30 (4), 348-349.

8) Fusi F., Valoti M., Petkov G., Boev K.K. and Sgaragli G.P. (1994). Effects of BHA on

plasmalemmal and intracellular Ca2+ transport in guinea pig gastric fundus. Pharmacol. Res.,

30 (4), 349-350.

9) Gorelli B., Pessina F., Fusi F., Valoti M., Marazova K. and Sgaragli G.P. (1995). Calcium

antagonist properties of some hindered phenols on rat aortic rings. Pharmacol. Res., 31

(suppl.), 206.

10) Fusi F., Conforti L., Scarlett J.A. and Callingham B.A. (1995). The effect of allylamine

on the tension responses of cervine digital arteries in vitro to noradrenaline. Br. J.

Pharmacol., 116, 414P.

11) Frosini M., Fusi F., Palmi M., Bianchi L., Della Corte L. and Sgaragli G.P. (1996).

Taurine and calcium changes in rabbit CSF during exposure to high temperatures. Eur. J.

Neurosci., 9 (suppl.), 41.

12) Palmi M., Fusi F., Youmbi G., Frosini M., Sgaragli G.P., Della Corte L., Bianchi L. and

Tipton K.F. (1996). Effects of taurine on Ca2+ uptake and oxidative phosphorylation in

mitochondria. Eur. J. Neurosci., 9 (suppl.), 41.

13) Fusi F., Galgani F., Gorelli B., Valoti M. and Sgaragli G.P. (1997). Pleiotypic effects of

2,5-di-t-butyl-1,4-benzohydroquinone (BHQ) on vascular smooth muscle. Pharmacol. Res.,

35 (suppl.), 77.


on cervine vascular reactivity. Pharmacol. Res., 35 (suppl.), 225-226.

15) White R., Fusi F., Scarlett J.A. and Callingham B.A. (1997). Seasonal differences in the

reactivity of fallow deer digital artery. J. Auton. Pharmacol., 17, 217.

16) Fusi F., Tzankova V., Galgani F., Valoti M. and Sgaragli G.P. (1999). Effect of 3,5-di-t-

butyl-4-hydroxyanisole (DTBHA) on sarcoplasmic reticulum Ca2+

-ATPase of rat skeletal

muscle. Pharmacol. Res., 39 (suppl.), 26.

17) Fusi F., Saponara S., Gorelli B., Alov P., Pessina F. and Sgaragli G.P. (1999).

Antispasmodic and antioxidant properties of some newly synthesised hindered phenols.

Pharmacol. Res., 39 (suppl.), 88.

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18) Petkov G.V., Gagov H.S., Fusi F., Corsi M., Sgaragli G.P. and Boev K.K. (1999).

Calcium current in freshly isolated smooth muscle cells from rat tail artery. Pharmacol. Res.,

39 (suppl.), 54.

19) Petkov G.V., Gagov H.S., Fusi F., Sgaragli G.P. and Boev K.K. (1999). Effects of t-butyl

phenols on calcium current in smooth muscle cells. Pharmacol. Res., 39 (suppl.), 54.

20) Fusi F., Saponara S., Gagov H. and Sgaragli G.P. (2001). 2,5-Di-t-butyl-1,4-

benzohydroquinone (BHQ) inhibition of vascular L-type Ca2+

channel is mediated by

superoxide anion. Pharmacol. Res., 43 (suppl. A), 23.

21) Saponara S., Fusi F., Pessina F., Gorelli B., Vittori L. and Sgaragli G.P. (2001). Effects of

quercetin on vascular smooth muscle. Pharmacol. Res., 43 (suppl. A), 24.



as a new MDR reverter devoid of vascular effects. J Chemother., 16 (suppl. 1).

23) Dragoni S., Valoti M., Fusi F., Saponara S. and Sgaragli G.P. (2006). Red wine and

health. Phytother. Res., 20, 327-328.

24) Schubert R., Saponara S., Fusi F., Iozzi D. (2007). The flavonoid quercetin relaxes

arteries by decreasing cytosolic and stored calcium. Acta Physiol., 189 (suppl. 653) O02-2.

25) Saponara S., Iozzi D., Fusi F., Sgaragli G. (2008). Plant polyphenols as modulators of

vascular ion channels. Acta Biochim. Pol., 55 (suppl. 1), 26-27.

26) Saponara S., Fusi F., Sgaragli G. (2008). Quercetin antagonism of Bay K 8644 effects on

rat tail artery L-type Ca2+

channels. Fundam. Clin. Pharmacol., 22 (suppl 2), 62.

27) Lacava C., Michalek-Sauberer A., Kraft B., Sgaragli G., Sipos E., Höller C., Kress H-G., Fusi

F., Weigl L.G. (2009). 3,5-Di-t-butyl catechol (DTCAT) as an activator of the human skeletal

muscle ryanodine receptor Ca2+

channel and its evaluation as a test substance for the

assessment of susceptibility to malignant hyperthermia. BMC Pharmacology, 9 (Suppl

2):A22.

28) Fusi F. (2011). Vascular ion channels as targets of wine polyphenols and their

metabolites: a possible explanation for their beneficial health effects. Eur. J. Nutr., 50, 491.

29) Saponara S. Durante M., Frosini M., Gorelli B., Valoti M., Chegaev K., Sgaragli G., Fusi

F. (2014). Screening for potential hazard effects from multitarget anthracycline on the

cardiovascular system. Anticancer Res., 34, 6153.

NATIONAL AND INTERNATIONAL MEETINGS

1) Valoti M., Fusi F., Zilletti L. and Sgaragli G.P. (1990). Peroxidation under anaerobic

conditions of arachidonic acid catalyzed by horseradish peroxidase in the presence of

hydroperoxide(s) of arachidonic acid. 7th International Conference on Prostaglandins and

Related Compounds. Florence, Italy, May 28-June 1.

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2) Valoti M., Fusi F., Gorelli B., Palmi M. and Sgaragli G.P. (1991). Nifedipine-like

properties in normal and skinned ileum longitudinal muscle in rat and antiperoxidant activities

of some hindered phenols.VI Meeting of the Italian Society of Pharmacognosy. Rome, Italy,

October 10-12.

3) Fusi F., Valoti M., Gorelli B., Mantovani P. and Sgaragli G.P. (1992). Calcium antagonist

properties on rat ileum longitudinal muscle of 2-t-butyl-4-methoxyphenol (BHA). XXVI

National Congress of the Italian Society of Pharmacology. Naples, Italy, September 29-

October 3.

4) Zilletti L., Gentilini M.G., Franchi-Micheli S., Mugnai S., Ciuffi M., Valoti M., Moneti G.,

Fusi F. and Sgaragli G.P. (1992). Cyclooxygenase activity of haemoglobin: a comparative

study in different species. XXVI National Congress of the Italian Society of Pharmacology.

Naples, Italy, September 29-October 3.

5) Zilletti L., Ciuffi M., Franchi-Micheli S., Fusi F., Gentilini G., Moneti G., Valoti M. and

Sgaragli G.P. (1993). Haemoglobin-catalyzed metabolism of arachidonic acid. Riunione

monotematica nazionale of the Italian Society of Pharmacology. Siena, Italy, May 24.

6) Valoti M., Fusi F. and Sgaragli G.P. (1993). Free radical inactivation by some antioxidant

hindered phenols in biological systems. Riunione monotematica nazionale of the Italian

Society of Pharmacology. Siena, Italy, May 24.


plasmalemmal and intracellular Ca2+ transport in guinea pig gastric fundus smooth muscle.

Riunione monotematica nazionale of the Italian Society of Pharmacology. Siena, Italy, May

24.

8) Fusi F., Valoti M., Gorelli B., and Sgaragli G.P. (1993). Calcium antagonist and

antiperoxidant properties of hindered phenols.International meeting on: Pathophysiology of

the prooxidant/antioxidant balance. Molecular basis of medical application. Siena, Italy, June

24-26.

9) Fusi F., Valoti M., Gorelli B. and Sgaragli G.P. (1993). Calcium antagonist properties of

antioxidant hindered phenols. International symposium on antioxidant and disease prevention.

Stockholm, Sweden, June 30-July 3.


plasmalemmal and intracellular Ca2+ transport in guinea pig gastric fundus smooth muscle. V

Joint meeting between the British and Italian Societies of Pharmacology. Rome, Italy,

September 13-16.

11) Zilletti L., Ciuffi M., Franchi-Micheli S., Fusi F., Gentilini G., Mugnai S., Valoti M. and

Sgaragli G.P. (1993). Metabolism of arachidonate catalyzed by haemoglobin. V Joint meeting

between the British and Italian Societies of Pharmacology. Rome, Italy, September 13-16.

12) Fusi F., Valoti M., Petkov G., Boev K.K. and Sgaragli G.P. (1994). Meccanismi

dell'azione spasmolitica del BHA sulla muscolatura liscia isolata dal fondo di stomaco di

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cavia. Metodi Innovativi in Farmacologia, Gruppo Nazionale MURST 40%. Florence, Italy,

May 30.

13) Fusi F. (1994). Derivati fenolici di origine naturale o sintetici con proprietà antiossidanti

e calcioantagonistiche come farmaci per la prevenzione dei danni tissutali da ischemia-

riperfusione susseguenti a infarto miocardico e ictus cerebrale. National Meeting of Ph.D.

Students in Pharmaceutical Sciences, Urbino, Italy, September 5-9.

14) Fusi F., Valoti M., Petkov G., Boev K.K. and Sgaragli G.P. (1994). Spasmolysis by 2-t-

butyl-4-methoxyphenol in guinea pig gastric fundus smooth muscle contracted with

cyclopiazonic acid or tetraethylammonium. 6th International Symposium on Pharmacological

control of calcium and potassium homeostasis. Florence, Italy, October 4-6.

15) Giacobini E., Mori F., Lai C-C., and Fusi F. (1995). The effect of cholinesterase

inhibitors on the secretion of APPs from in rat brain cortex. In: Novel Therapeutic

Approaches to AD and other Memory Disorders Associated with Aging. Zurich, Switzerland.

16) Gorelli B., Pessina F., Fusi F., Valoti M., Marazowa K. and Sgaragli G.P. (1995).

Calcium antagonist properties of some hindered phenols on rat aortic rings. First European

Congress of Pharmacology. Milan, Italy, June 16-19.

17) Palmi M., Fusi F., Youmbi G., Frosini M., Sgaragli G.P., Dixon H. and Tipton K.F.

(1995). Effects of taurine and structurally-related analogues on Ca2+-uptake and respiration

rate in rat liver mitochondria. International Taurine Symposium '95. Taurine: basic and

clinical aspects. Osaka, Japan, June 27-July 1.

18) Sgaragli G.P., Frosini M., Palmi M., Fusi F., Sesti C., Della Corte L., Bianchi L., Galeffi

F., Bolam P., Dixon H. and Tipton K.F. (1995). Behavioural and cellular studies on some

compounds structurally-related to taurine. International Taurine Symposium '95. Taurine:

basic and clinical aspects. Osaka, Japan, June 27-July 1.


on the tension responses of cervine digital arteries in vitro to noradrenaline. Autumn Meeting

of the British Pharmacological Society, University of Strathclyde, Glasgow, U.K., September

6-8.

20) Fusi F., Gorelli B., Pessina F., Valoti M., Marazova K. and Sgaragli G.P. (1995).

Proprietà calcio antagonisctiche di alcuni derivati fenolici su anelli di aorta di ratto. Metodi

Innovativi in Farmacologia, Gruppo Nazionale MURST 40%. Florence, Italy, October 20-21.


on cervine vascular reactivity. Riunione congiunta monotematica delle Società Italiane di

Farmacologia e di Tossicologia sul metabolismo degli xenobiotici. Siena, Italy, November 3-

4.

22) White R., Fusi F., Scarlett J.A. and Callingham B.A. (1996). Seasonal differences in the

reactivity of fallow deer digital artery. 9th Meeting on Adrenergic Mechanisms. Porto,

Portugal, September 22-25.

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Taurine and calcium changes in rabbit CSF during exposure to high temperatures. 2nd

Meeting of European Neuroscience. Strasbourg, France, September 24-28.

24) Palmi M., Fusi F., Youmbi G., Frosini M., Sgaragli G.P., Della Corte L., Bianchi L. and

Tipton K.F. (1996). Effects of taurine on Ca2+ uptake and oxidative phosphorylation in

mitochondria. 2nd Meeting of European Neuroscience. Strasbourg, France, September 24-28.


Concentrazioni di taurina e Ca2+ nel CSF di coniglio durante esposizione ad alte temperature.

V Convegno Nazionale Giovani Cultori delle Neuroscienze. Pisa, Italy, December 12-14.


2,5-di-t-butyl-1,4-benzohydroquinone (BHQ) on vascular smooth muscle. XXVIII National

Congress of the Italian Society of Pharmacology. Bari, Italy, April 30 - May 3.

27) Palmi M., Youmbi G., Fusi F., Frosini M., Sgaragli G.P., Della Corte L., Bianchi L. and

Tipton K.F. (1997). Effect of taurine on calcium transport in rat liver mitochondria.

International Taurine Symposium '97. Neurochemistry, biochemistry and pharmacology.

Tucson, Arizona, USA, July 15-19.


2,5-di-t-butyl-1,4-benzohydroquinone (BHQ) on vascular smooth muscle. First Virtual

Congress about Pharmacy (IVCP), University of Granada, Faculty of Pharmacy, Research

Group of Pharmaceutical Physical Chemistry (PAI), Computing and Network

Communications Services Centre, Spain, January-December 1998.

29) Fusi F., Corsi M., Pessina F., Galgani F. and Sgaragli G.P. (1998). Effects of 2,5-di-t-

butyl-1,4-benzohydroquinone (BHQ) on rat aorta endothelium-dependent relaxation. 6th joint

meeting of the Italian, Hungarian and Polish pharmacological societies. Pisa, Italy, May 14-

16.

30) Tchuisseu Youmbi G., Palmi M., Fusi F., Frosini M., Sgaragli G.P., Della Corte L. and

Tipton K.F. (1998). Effects of taurine on Ca2+ transport in rat liver mitochondria. 6th joint

meeting of the Italian, Hungarian and Polish pharmacological societies. Pisa, Italy, May 14-

16.

31) Pessina F., Marazova K., Gorelli B., Fusi F. and Sgaragli G.P. (1998). Antispasmodic

effects of some sterically hindered phenols on rat aorta ring preparations. 6th joint meeting of

the Italian, Hungarian and Polish pharmacological societies. Pisa, Italy, May 14-16.

32) Fusi F., Corsi M., Pessina F., Galgani F. and Sgaragli G.P. (1998). Effects of 2,5-di-t-

butyl-1,4-benzohydroquinone (BHQ) on rat aorta endothelium-dependent relaxation.

International symposium on cell injury from reperfusion and oxidative stress: new

pharmacological strategies for neuroprotection. Siena, Italy, November 9.

33) Tzankova V., Fusi F., Galgani F., Valoti M. and Sgaragli G.P. (1998). Effect of some

phenol derivatives on sarcoplasmic reticulum Ca2+

-ATPase of rat skeletal muscle.

International symposium on cell injury from reperfusion and oxidative stress: new

pharmacological strategies for neuroprotection. Siena, Italy, November 9.

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34) Fusi F., Tzankova V., Galgani F., Valoti M. and Sgaragli G.P. (1999). Effect of 3,5-di-t-

butyl-4-hydroxyanisole (DTBHA) on sarcoplasmic reticulum Ca2+

-ATPase of rat skeletal

muscle. XXIX National Congress of the Italian Society of Pharmacology. Florence, Italy,

June 20-23.

35) Fusi F., Saponara S., Gorelli B., Alov P., Pessina F. and Sgaragli G.P. (1999).

Antispasmodic and antioxidant properties of some newly synthesised hindered phenols.

XXIX National Congress of the Italian Society of Pharmacology. Florence, Italy, June 20-23.

36) Petkov G.V., Gagov H.S., Fusi F., Corsi M., Sgaragli G.P. and Boev K.K. (1999).

Calcium current in freshly isolated smooth muscle cells from rat tail artery. XXIX National

Congress of the Italian Society of Pharmacology. Florence, Italy, June 20-23.

37) Petkov G.V., Gagov H.S., Fusi F., Sgaragli G.P. and Boev K.K. (1999). Effects of t-butyl

phenols on calcium current in smooth muscle cells. XXIX National Congress of the Italian

Society of Pharmacology. Florence, Italy, June 20-23.

38) Palmi M., Tchuisseu Youmbi G., Davey G., Meini A., Benocci A., Fusi F., Frosini M.,

Sgaragli G.P. and Tipton K.F. (1999). Taurine and mitochondria Ca2+ accumulation.

International Taurine Symposium 1999. Taurine and Excitable Tissues. Siena, Italy, August

4-8.

39) Sesti C., Frosini M., Palmi M., Valoti M., Fusi F., Bianchi L., Della Corte L. and Sgaragli

G.P. (1999). Changes in cerebrospinal fluid composition in conscious rabbit exposed to high

ambient temperatures: the possible role of taurine and GABA as cryogens. International

Taurine Symposium 1999. Taurine and Excitable Tissues. Siena, Italy, August 4-8.

40) Fusi F., Saponara S., Gagov H. and Sgaragli G.P. (1999). The patch-clamp technique:

development and uses to investigate Ca2+

currents. Accademia dei Fisiocritici, Siena, Italy,

November 24.

41) Fusi F., Saponara S., Pessina F., Gorelli B., Vittori L. and Sgaragli G.P. Effetto dei

polifenoli del vino sulla contrazione e sulla corrente del calcio nel muscolo vascolare.

Convegno "Vino e Salute: aspetti economici, sociali e medici". Siena, Italy, 11 December

2000.

42) Fusi F., Saponara S., Pessina F., Gorelli B., Vittori L. and Sgaragli G.P. Effects of wine

polyphenols on vascular functions: an electro-mechanic investigation. European Conference.

Bioactive Compounds in Plant Foods. Health effects and perspectives for the food industry.

Tenerife, Canary Islands, Spain, 26-28 April 2001.

43) Fusi F., Saponara S., Gagov H. and Sgaragli G.P. 2,5-Di-t-butyl-1,4-benzohydroquinone

(BHQ) inhibition of vascular L-type Ca2+

channel is mediated by superoxide anion. XXX

National Congress of the Italian Pharmacological Society. Genoa, Italy, May 30-June 2, 2001.

44) Saponara S., Fusi F., Pessina F., Gorelli B., Vittori L. and Sgaragli G.P. Effects of

quercetin on vascular smooth muscle. XXX National Congress of the Italian Pharmacological

Society. Genoa, Italy, May 30-June 2, 2001.

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45) Saponara S., Fusi F., Pessina F., Gorelli B., and Sgaragli G. Effects of wine polyphenols

on vascular smooth muscle. Dietary phytochemicals and human health. Salamanca, Spain,

April 18-20, 2002.

46) Valoti M., Ponticelli F., Fontani M., Fusi F., Saponara S., Pessina F. and Sgaragli G.P.

Effects of novel antioxidants, phenol derivatives on human erythrocytes under oxidative stress

promoted by AAPH. XIII National Congress of the Italian Toxicological Society. Urbino,

Italy, January 22-25, 2003.

47) Saponara S., Frosini M., Sgaragli G.P. and Fusi F. Interactions between two Ca2+

channel

activators, quercetin and BAY K 8644, in vascular smooth muscle. XXXI Congresso

Nazionale della Società Italiana di Farmacologia. Trieste, Italy, June 26-29, 2003.

48) Fusi F., Saponara S., Pessina F., Gorelli B. and Sgaragli G.P. Flavonoids: a new class of

vascular smooth muscle L-type Ca2+

channel modulators. XXXI Congresso Nazionale della

Società Italiana di Farmacologia. Trieste, Italy, June 26-29, 2003.



as a new MDR reverter devoid of vascular effects. 1st ISC International Conference on Cancer

Therapeutics, Molecular Targets, Pharmacology and Clinical Applications. Florence, Italy,

February 19-21, 2004.

50) Fusi F., Saponara S. and Sgaragli G.P. (2004). Effects of quercetin and some flavonoids,

structurally related to it, on L-type Ca2+

current of rat tail main artery myocytes. "Flavonoidi

Chimica, Farmacognosia, Farmacologia ed Impiego Terapeutico". Naples, Italy, April 3,

2004.

51) Saponara S., Kawase M., Shah A., Motohashi N., Molnar J., Ugocsai K., Fusi F. and

Sgaragli G. (2004). 3,5-Dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine

(DP7) as a new MDR reverter devoid of effects on vascular smooth muscle contractility.

Giovanni Armenise-Harvard Foundation 8th Annual Symposium on Cancer Biology and

Genomics and Post-Genomics. Siena, Italy, May 21-23, 2004.

52) Fusi F., Saponara S. and Sgaragli G.P. Effects of quercetin and other structurally related

flavonoids on L-type Ca2+

current of rat tail main artery myocytes. European Workshop on

Cellular responses to bioactive plant compounds - implications for human health. Budapest,

Hungary, September 30-October 2, 2004.

53) Fusi F., Saponara S., Kawase M., Shah A., Motohashi N., Molnar J., Ugocsai K. and

Sgaragli G. 3,5-Dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7) as a

new multidrug resistance reverting agent devoid of effects on vascular smooth muscle

contractility. Pharmacological strategies to overcome multidrug resistance in cancer

chemotherapy. Siena, Italy, November 22, 2004.


Fusi F. 3,5-Dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7) as a

new multidrug resistance reverting agent devoid of effects on vascular smooth muscle

contractility. International Symposium on Reversal of Multidrug Resistance in Cancer Cells.

Szeged, Hungary, December 13, 2004.

2

0

55) Saponara S., Fusi F., Iozzi D., Lorusso F., Sgaragli G. Mechanism of myricetin

stimulation of vascular L-type Ca2+

current. XXXII Congresso Nazionale della Società

Italiana di Farmacologia. Naples, Italy, June 1-4, 2005.

56) Fusi F., Gelli M., D’Elia P., Saponara S., Molnar J. and Sgaragli G. Vascular effects of

new silicon compounds active as resistance modifier against multidrug-resistant cancer cells.

Pharmacological strategies to overcome multidrug resistance in cancer chemotherapy. II

Annual Symposium. Siena, Italy, November 22, 2005.

57) Ioan P., Budriesi R., Ugenti M.P., Chiarini A., Carosati E., Cruciani G., Spinelli D.,

Cosimelli B., Novellino E., Fusi F., Frosini M., Gasparrini F., Stephen P.J. Un Approccio

Multidisciplinare per lo Studio di Nuovi Modulatori dei Canali del Ca2+

di tipo-L. Med.

Chem. Division of the XXII Congresso Nazionale della Società Chimica Italiana. Florence,

Italy, September 10-15, 2006.

58) Fusi F., Saponara S., Testai L., Iozzi D., Martinotti E., Martelli A., Chericoni S., Sgaragli

G., Calderone V. (+/-)-Naringenin as KCa 1.1 channels opener in vascular smooth muscle

cells. Molecular and physiological effects of bioactive food compounds. Wien, Austria,

October 11-14, 2006.

59) Sgaragli G., Fusi F., Saponara S. Functional interactions between two L-type Ca2+

channel activators, quercetin and Bay K 8644, in rat tail artery myocytes. Molecular and

physiological effects of bioactive food compounds. Wien, Austria, October 11-14 2006.

60) Alderighi D., Gori M., Sgaragli T., Dragoni S., Frosini M., Valoti M., Saponara S., Fusi

F., Kawase M., Shah A., Motohashi N., Molnar J., Sgaragli G. Inhibition of P-gp/ATPase

activity of rat small intestine membrane vesicles by the novel, dihydropyridine MDR reverter

DP7. Pharmacological strategies to overcome multidrug resistance in cancer chemotherapy.

III Annual Symposium. Certosa di Pontignano, Siena, Italy, November 14, 2006.

61) Lacava C., Sipos E., Höller C., Kress H.G., Sgaragli G., Fusi F., Weigl L. Use of 3,5 di-t-

butylcatechol (DTCAT) in the diagnosis of malignant hyperthermia (MH). European

Malignant Hyperthermia Group 2007 Meeting, Certosa di Pontignano, Siena, Italy, May 20-

23, 2007.

62) Alderighi D., Sgaragli T., Dragoni S., Frosini M., Valoti M., Saponara S., Fusi F., Shah

A., Kawase M., Motohashi N., Molnar J., Sgaragli G. Inhibition of P-gp/ATPase activity of

rat small intestine membrane vesicles by the novel, dihydropyridine MDR reverter DP7.

XXXIII Congresso Nazionale della Società Italiana di Farmacologia. Cagliari, Italy, June 6-9,

2007.

63) Ferrara A., Fusi F., Koorbanally C., Crouch N.R., Mulholland D.A., Sgaragli G. Vascular

activity of isolates from the hyacinthaceae of South Africa. XXXIII Congresso Nazionale

della Società Italiana di Farmacologia. Cagliari, Italy, June 6-9, 2007.

64) D’Elia P., Dragoni S., Valoti M., De Matteis F., Saponara S., Fusi F., Sgaragli G.

Inhibition studies of DP7, a novel MDR reverter,on CYP-dependent activities in human and

rat liver microsomes. Pharmacological strategies to overcome multidrug resistance in cancer

2

1

chemotherapy. IV Annual Symposium. Certosa di Pontignano, Siena, Italy, November 19-20,

2007.

65) Saponara S., Fusi F., Ricci L., Frosini M., Dragoni S., Valoti M., Valeri A., Pessina F.,

Sgaragli G. I polifenoli di origine naturale e la salute umana: effetti su rilevanti bersagli

farmacologici. Congresso Nazionale: Farmaci Naturali. Attualità e Prospettive Future.

Benevento, Italy, March 27-29, 2009.

66) Fusi F. (2011). Vascular ion channels as targets of wine polyphenols and their

metabolites: a possible explanation for their beneficial health effects. Seminario Scientifico

sul bere responsabile nella dieta mediterranea e nello stile di vita italiano. Certosa di

Pontignano, Siena, Italy, 10-11 giugno 2011.

67) Neri A., Frosini M., Saponara S., Fusi F., Dragoni S., Cacace M., Dei S., Teodori E.,

Valoti M., Sgaragli G. New approaches for reversing cancer multidrug resistance. La

farmacologia oncologica tra innovazione ed evidenza clinica. Siena, Italy, November 30-

December 1, 2012.

68) Durante M., Neri A., Frosini M., Valoti M., Sgaragli G., Fusi F., Chegaev K., Saponara

S. Screening for potential hazard effects from multitarget anthracyclines on vasculature.

XXXVI Congresso Nazionale della Società Italiana di Farmacologia. Turin, Italy, October 23-

26, 2013.

69) Durante M., Cuong N.M., Khanh P.N., Huyen P.T., Ha V.T., Duc H.V., Huong T.T., Tai

B.H., Binh N.Q., Sgaragli G., Fusi F. In vitro vasoactivity of novel natural leads from

Vietnamese medicinal plants. XXXVI Congresso Nazionale della Società Italiana di

Farmacologia. Turin, Italy, October 23-26, 2013.

70) Durante M., Sgaragli G., Huong T.T., Cuong N.M., Fusi F. Vascular L-type Ca2+

channel

mediated activity of murrayafoline A from Glycosmis stenocarpa: electrophysiological and

molecular docking studies. Convegno Monotematico della Società Italiana Di Farmacologia,

Gruppo di Lavoro Farmacognosia. Farmacognosia: nuove opportunità terapeutiche dal mondo

vegetale. Naples, Italy, June 20-21, 2014.

71) Durante M., Frosini M., Fusi F., Maestrini V., Gorelli B., Valoti M., Chegaev K.,

Saponara S. Screening for potential hazard effects from a multitarget anthracycline on the

cardiovascular system. XXXVII Congresso Nazionale della Società Italiana di Farmacologia.

Naples, Italy, 27-30 October, 2015.

curriculum vitae - unisi.it · 2017-11-13 · curriculum vitae name: fabio fusi date and place of...

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