curriculum vitae ruben baler, ph. d.€¦ · 1 curriculum vitae ruben baler, ph. d. (2017) 8524...
TRANSCRIPT
1
CURRICULUM VITAE
RUBEN BALER, Ph. D.
(2017)
8524 Milford Avenue
Silver Spring, MD 20910
Day phone: 301 594 6790
Eve. phone: 301 495 2331
E-mail: [email protected]
Country of Citizenship: U.S.A.
- Científico de la Salud en el NATIONAL INSTITUTE ON DRUG ABUSE, NIDA, desde 2004, en la Oficina de Comunicación en Políticas Públicas Científicas y Comunicación (OSPC) Perteneciente al NATIONAL INSTITUTES OF HEALTH, NIH (EEUU), (6002 Executive Blvd, Bethesda MD 20892.)
2
El Lic. Rubén Baler es un invitado de particular importancia pues al momento actual la Argentina se encuentra frente a un agudo crecimiento del consumo de sustancias. Además de las políticas regulatorias que dictan las leyes aprobadas por los poderes que corresponden, es evidente la necesidad de prevenir a la población para disminuir la demanda. Educar para la vida sana y sobre las consecuencias negativas para la salud, dedicándose especialmente a niños y adolescentes con métodos eficaces y comprobables científicamente. Es necesario que toda la sociedad se involucre en esta tarea. Se requieren claridad de objetivos y persistencia en todos los ámbitos. Su extenso curriculum demuestra su intensa dedicación a políticas de Prevención de las adicciones, desarrollo normal y la difusión de las bases neurobiológicas de los daños en la salud que provocan las mismas. Desde su cargo de Científico de la Salud en el Instituto Nacional (NIDA) sobre el Abuso de Drogas (NIH), sus actividades convergen en la educación y difusión de las neurociencias y en particular la PREVENCIÓN Y TRATAMIENTO DE LA DROGADICCIÓN. Bajo la dirección de la Dra. Nora Volkow. Dichas actividades incluyen varios modos de comunicación (como artículos, conferencias, asesorías, cursos y entrevistas) cuyo propósito es el de capacitar y dar protagonismo real a la población general, Profesionales de la salud, y agentes gubernamentales con la información crítica que les permita conducir una toma de decisiones racional y basada en las evidencias científicas. En los últimos 10 años, y por encargo de la Directora del Instituto, Dra. Nora Volkow, Presidente del NIDA, sus responsabilidades se han extendido: Hoy incluyen el “rol de liaison” del NIDA en Hispanoamérica dada su facilidad de expresión en el idioma castellano. Esto ha permitido establecer relaciones fértiles de educación y/o asesoría en la OEA, la OPS y además con diferentes grupos involucrados en la problemática de la droga en México, Costa Rica, Chile, y Colombia. El Lic. Rubén Baler es un neurocientífico que tiene una fecunda y abundante actividad en el campo de estrategias comunicacionales para la difusión de conocimientos y métodos preventivos científicamente probados, sobre las adicciones. Es de su especial interés dar conferencias a grupos de padres e hijos, estudiantes adolescentes, maestros, docentes universitarios, trabajadores sociales, personal involucrado en prevención y tratamiento de adicciones y al público en general, en audiencias públicas para grupos no entrenados en los aspectos científicos de las adicciones (en castellano y en ingles). Ha desarrollado innovadoras técnicas de propagación de conocimientos transformadores destinados a mejorar las conductas sanas, tanto en las personas, sus familias y en la sociedad con sus diferentes componentes. Realiza estas actividades en EEUU y en diferentes países latinoamericanos.
3
EDUCATION
Nacido en Buenos Aires el 20 / 3 / 1960 1979-1982. Baccalaureate in Science; Major in Biology, Hebrew University of
Jerusalem, Israel. Degree awarded in July 1982.
1982-1984. Master of Science; Major in Microbiology and Immunology, Hebrew
University of Jerusalem, Israel.
Research topic: Autoimmune disease in a rodent model. Degree awarded in July
1984.
1984-1992. Doctor of Philosophy; Major in Microbiology-Immunology and
Cellular and Molecular Biology, University of Miami-Coral Gables, Fl. Research
topic: Transcriptional control of the Stress Response. Degree awarded in July
1992.
- LICENCIADO Y MASTER OF SCIENCE: Microbiology and Immunology,
Hebrew University of Jerusalem, Israel
- DOCTOR OF PHILOSOPHY; Major in Microbiology-Immunology and Cellular and
Molecular Biology, University of Miami, EEUU
- DOCTORADO EN MICROBIOLOGÍA Y BIOLOGÍA MOLECULAR -
Miami en 1993.
Realizó sus estudios de Post-doctorado en el Instituto Nacional de Salud Infantil y Desarrollo Humano, (de los Institutos Nacionales de la Salud de los EEUU, NIH) donde se especializó en Cronobiología Molecular. Luego se trasladó al Instituto Nacional de Salud Mental (NIH), donde realizó investigaciones básicas sobre las bases moleculares de la expresión genética circadiana en vertebrados. En octubre del 2004 se incorporó a la División de Políticas Científicas de la Oficina de Políticas Científicas y Comunicaciones del Instituto Nacional de Abuso de Drogas (NIH) donde se desempeña, hasta la fecha como Científico de la Salud. Sus primeras publicaciones se han centrado en la regulación temporal de la expresión génica en el reloj cerebral. Desde que se unió al NIDA, ha escrito y dictado
4
conferencias, nacional e internacionalmente, sobre la Neurobiología del Abuso y Adicción a las Drogas y sobre los principios de Prevención en base a la evidencia. El Dr. Baler combina la perspectiva adquirida de disciplinas diversas (entre las que se cuentan la biología celular y molecular, la genética, la inmunología, la bioinformática, la neurociencia y la neuroética, para promover la misión científica del NIDA.
EMPLOYMENT October 2004- present
Health Scientist, Office of Science Policy and Communications (OSPC), National Institute on Drug Abuse, National Institutes of Health, 6002 Executive Blvd, Bethesda MD 20892. Duties Provide scientific expertise on the neurobiology of drug abuse; write scientific articles and reviews, congressional justifications; propose and organize scientific meetings and shape science-based dissemination materials and public initiatives. Lecture about the brain and the science, prevention and treatment of drug addiction at the college level and for lay audiences. Represent NIDA at various trans-NIH and trans-HHS Agencies bioethics task forces. Ad Hoc Spanish spokesman for NIDA.
January 1998 – September 2004 Principal Investigator, Unit on Temporal Gene Expression. Research topic:
Transcriptional control in the mammalian circadian clock.
National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892. Supervisor: Dr. Miles Herkenham, Chief, Laboratory of Cellular and Molecular Regulation, NIMH, NIH.
Duties
Chief of the Unit on Temporal Gene Expression, NIMH. Leader of a basic neuroscience research team working on transcriptional control in the mammalian circadian system. Coordinate, plan, execute and report ongoing scientific projects in the laboratory. Administer operating budget of the laboratory ($100K+ annually) and manage human resources (up to 4 workers).
September 1993 - December 1997
Postdoctoral Fellow-supported by a National Research Council
Associateship Program Award. Laboratory of David Klein, NICHD (NIH).
9000 Rockville Pike, Bethesda, MD 20892.
Duties
5
Independent research on signal transduction and the molecular basis of circadian regulation in the rat pineal gland: a classic model of Neuroendocrine specific gene regulation.
May 1992 - August 1993
Postdoctoral fellow-Supported by a University of Miami, Coral Gables.
Teaching assistant award.
Laboratory of Richard Voellmy. Department of Biochemistry and Molecular
Biology, University of Miami, Fl. ([email protected])
Participated in ongoing research on the early molecular events in the transduction of stress signals.
Discovered that the activation of the Heat Shock Transcription Factor 1 (HSF-1) requires the physical dissociation between HSF-1 and HSP70. Published three highly cited peer reviewed articles.
October 1987- July 1989
Teaching assistant. Department of Microbiology and Immunology, University of
Miami Medical School, Fl.
Assisted in the teaching of Medical Microbiology and Immunobiology courses for medical students. Leader of small group discussions and laboratory practice rotations.
November 1984 - July 1986
Research Fellow, supported by the National Council of Research, Science and Technology (CONICET)- Argentina
Center for the study of Pharmacological and Natural Principles (CEFAPRIN), Buenos
Aires-Argentina. Supervisor: Dr. Marta Braun.
Participated in ongoing research in the area of Neuroimmune-modulation in a mouse model of graft vs. host reaction.
July 1983 - March 1984
Clinical Chemist. Department of Clinical Biochemistry, Hadassah University Hospital, Jerusalem, Israel. Performed emergency diagnostic tests in the special afternoon and night services.
October 1979 - July 1980
Research assistant. Department of Life Sciences-Guivat Ram. Hebrew University of
Jerusalem, Israel. Supervisor: Dr. Haggai Guinzburg . Participated in ongoing research
related to the development of novel drugs for the treatment of malaria.
6
PUBLICACIONES EN LIBROS
George F. Koob, Denise B. Kandel, Ruben D. Baler, Nora D. Volkow.
Eds: Tasman, Kay, Lieberman, First, and Riba. in: Psychiatry, 2 Volume Set, 4th
Edition. Chapter 22. Pathophysiology of Addiction p:359, 359. (ISBN: 978-1-118-
84547-9)
Klein, D. C., S. L. Coon, P. H. Roseboom, J. L. Weller, M. Bernard, J. A. Gastel, M. Zatz, P. M. Iuvone, I. R. Rodriguez, V. Begay, J. Falcon, G. M. Cahill, V. M. Cassone, Baler R 1997 The melatonin rhythm-generating enzyme: molecular regulation of serotonin N-acetyltransferase in the pineal gland. Recent Prog. Horm. Res. 52:307-57; discussion 357-8.
PRESENTACIONES:
Science of Addiction. Keynote presentation to the drug addiction class of the GW
School of Public Health. September 28th. 2016. Washington DC.
The Science of Addiction. Annual Nursing Conference. August 10th, 2016 Kellogg
Conference Center at Gallaudet University.
The Neuroscience of Addiction, Risk and Prevention. Workshop at the 26th CADCA
National Leadership Forum, February 4th, 2016 National Harbor, MD.
Youth Forum with NIDA scientist. Presentation at the Mentor Foundation event, NDFW.
February 11th, 2016 IRP, Baltimore Campus.
Science of Addiction for STEM students. Special Presentation for the Biology Club at
the Prince George’s Community College. February 22nd, 2016 Largo, MD.
The Comorbidogenic Society. Keynote Address at the XVIII Annual Meeting of the
Spanish Society of Dual Pathology. April 12-16, 2016 Madrid, Spain.
Is Criticality Critical to understanding dual disorders? Lecture at the Dual Disorders
Symposium at the 169th APA Annual Meeting, May 14-18, 2016 in Atlanta, GA.
SCIENCE OF ADDICTION, PREVENTION, AND RESILIENCE. Lecture at the
Underage Drinking Town Hall Meeting for Prevention and Substance Abuse
Practitioners. DC Department of Behavioral Health, May 24, 2016. Washington DC.
Keynote on “Medical marijuana in the Americas: Risk, benefits and Regulatory Challenges“ Event organized in celebration of International Day against drug abuse and illicit trafficking. Pan American Health Organization (PAHO), Washington DC. July 1st 2015.
7
“MEDICAL MARIJUANA’ INTER-AMERICAN DRUG ABUSE CONTROL COMMISSION (C I C A D) Secretariat for Multidimensional Security FIFTY-SEVENTH REGULAR SESSION April 29, May 1, 2015 Washington, D.C. “The Science of Medical Marijuana” CICAD : Presentation, OAS, Washington DC April 30, 2015. “Delayed gratifications and dual pathologies: the price of modernity”
Main lecture at the IV International Congress on Dual Disorders. Barcelona April 2015
“Cannabis: New international regulation. What is the risk in Dual Disorders?” Speaker at Cannabis symposium. IV International Congress on Dual Disorders. Barcelona April, 2015 “Addiction: Uncovering neurobiological complexity” Speaker at symposium on neurobiological complexity. IV International Congress on Dual Disorders. Barcelona April, 2015 “The Neuroscience of Addiction” Workshop at DEA University, July 24, 2013. Quantico training grounds, Quantico, VA. “Where do Addictions come from?” workshop at the Community Anti-drug Coalitions of America (CADCA) 22nd Annual National leadership Forum. February 6-9, 2012. Gaylord National Hotel & Convention Center, National Harbor, MD.
GW Public Health class: The neurobiology of Drug Abuse: Addiction is a disease.
Regular Fall semester lecturer 2005-2012. GW Mount Vernon Campus. Washington
DC. Lectures in Spanish about “Prevention in schools and the neuroscience of dual pathologies” at the Fundación La Esperanza sponsored workshop., August 23-25, 2011. SOFOFA, Santiago de Chile. Chile. “Everything you wanted to know about drugs, but never dared to ask” workshop for kids and their kids at the PRIDE 2011 Youth teens Convention, April 14-15, 2011. Toledo, OH. “The science of Addiction” Keynote address at the 2009 Spring Academy: Prevention
and Treatment Exchange. May 18-20, 2009. Grand Sierra Resort, Reno, NV.
“The neurobiology of addiction” training the trainer workshop at the 2005 Mid-Year training institute of the Community Anti-drug Coalitions of America (CADCA). September 2007. Palm Springs, CA. “Contextual properties of circadian promoters”. Organizer and speaker at a biological clocks panel. Winter Conference on Brain Research, January 25-31, 2003 Snowbird, UT. “The Fra-2 oncogene: Bimodal transcriptional potential observed in vivo”. Invited speaker at the STADY III Symposium, October 1-4, 2002. Tel Aviv University, Tel Aviv, Israel.
8
“Molecular pathways in the Pineal Gland”, Invited lecturer at the Postgraduate Course on Biological Rhythms entitled Biochemical and Molecular Basis of Chronobiology. October 20-22, 2002. Los Cocos, Córdoba, Argentina. “The circadian E-Box”, Invited speaker at the Symposium on Circadian Rhythms during the Annual meeting of the Argentine Society of Neurochemistry (SAN), October 23, 2002. Los Cocos, Cordoba, Argentina.. “Searching for the circadian E-Box”. Invited speaker at the 8th meeting of the Society for Research on Biological Rhythms. Amelia Island Plantation, May 22-26, 2002. Jacksonville, Florida. “Decoding the rat AA-NAT promoter” Gordon Conference on Pineal Cell Biology. Feb 10 – 15, 2002. Ventura, California. . “AA-NAT promoter elements”. Invited speaker at the AANAT 2001 Workshop. Airlie Conference Center. May 13-15, 2001. Warrenton, Virginia. “Transcriptional regulation of Circadian Promoters”. Invited speaker at the Morehouse School of Medicine Neuroscience Institute – Neuroscience Lecture Series. February 26, 2001-Atlanta, Georgia. “The AA-NAT bullet: tissue specific targeting of transgene expression in the rat”. Invited lecturer at the 11th International Society of Endocrinology Congress. October, 2000 Sidney, Australia. “Transgenic knock-down of the fos-related antigen 2 in the rat pineal gland” Invited by the Department of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University. November 3, 2000 – Canberra, Australia. “Transgenic knock-down of the fos-related antigen 2 in the rat pineal gland” Invited by the Walter and Eliza Hall Institute of Medical Research - Melbourne, Australia. November 6, 2000 – Melbourne, Australia. The AA-NAT gene promoter. Gordon Conference on Pineal Cell Biology. February. 1998. Ventura, CA. Molecular rhythms in the rat pineal gland. At: Building a biological clock out of molecular rhythms, Interactive panel at the 30th annual Winter Conference on Brain Research, Jan 25 – Feb 1, 1997. Breckenridge, CO. Circadian Regulation of Transcription Factor Fra-2 in the rat pineal gland. 7th Colloquium of the European Pineal Society (EPS). March 29-31, 1996. Sitges, Spain. Circadian Expression of Pineal Fos Related Antigen 2 (Fra-2). Gordon Research Conference on Pineal Cell Biology. February 1996. Ventura, CA.
9
Molecular and cellular aspects of melatonin synthesis regulation in pineal gland and retina. Speaker at an interactive panel at the 29th Winter Conference on Brain Research. January, 1996. Snowmass, CO. Circadian Regulation of Transcription factor Fra-2 in the rat pineal gland: role for an adrenergic-cyclic AMP control mechanism. Gordon Conference on Chronobiology. Ill April, 1995. Ciocco, Italy. Speaker at the Transcription Factor session at the “Molecular Aspects of Pineal Signal Transduction Conference”. Airlie House, Sept ember, 1995. Warrenton, VA. Regulation of Fos related proteins in the rat pineal. Pineal Cell Biology-Gordon conference. March 1994. Oxnard, CA. HSF activation is linked to protein synthesis events: HSP70 may play a role in an autoregulatory loop. R. Baler, W. Welch and R. Voellmy. Poster presentation at the "Stress proteins and the heat shock response" meeting. April 1991. Cold Spring Harbor, New York, EEUU Selected topics in Current Immunology. Lecture at the Sociedad de Alergia e Inmunologia de Cordoba-Circulo Medico de Cordoba, July 1985. Cordoba, Argentina. T cell hybridomas: preparation and potential clinical applications. lecture in the series "Ateneos cientificos del Instituto Argentino de Alergia e inmunologia (IAAI). April 1985. Buenos Aires, Argentina Monoclonal lymphokines and their application in the study of autoimmune disorders.
Oral presentation at the Third International meeting of asthma, allergy and immunology,
December 1984. Buenos Aires, Argentina.
PUBLISHED ABSTRACTS Muñoz, E. Brewer, M. and Baler R. Potential modulation of Bmal/Clock/E-box complex by a novel, Zn++ regulated, CT-rich cis-acting element. (Submitted for a special issue of Molecular and Cellular Endocrinology) 2005 The cold inducible glycoprotein (CIG30) gene promoter: rhythmic control by clock and sterol signaling pathways. poster presented at the American Society for Cell Biology Minorities Affairs Committee; 43rd annual meeting, San Francisco. Oct. 2003. Baler R. The circadian E-Box Cell. Molecular Neurobiol. 23 (2): 224-224 APR 2003.
10
Cell-specific expression of Fra-2 messenger-RNA in pinealocytes and hippocampal-neurons - in-situ evidence linking fra-2 to the diurnal rhythm of melatonin synthesis. Hayes WP, Klein DC, Baler R Molecular Biology of the Cell 6: 2408-2408 suppl. s Nov 1995. Activation of human heat-shock genes is accompanied by oligomerization, modification and translocation of heat-shock transcription factor HSF-1. Baler R, Voellmy R. FASEB journal 7 (3): a200-a200 part 1 Feb. 1993. Activation of human heat-shock genes is accompanied by oligomerization, modification and translocation of heat-shock transcription factor HSF1. Baler R, Voellmy R. Journal of Cellular Biochemistry : 14-14 suppl. 17c Feb. 1993.
MEETINGS ORGANIZED “Neuregulin 1: A Gene at the Crossroads of Synaptic Plasticity, Psychiatric Disorders, and the Self Medication Theory of Smoking. A panel at the 2010 ACNP Annual meeting, entitled December 5-9, 2010, Miami Beach, Fl.
“Cognitive Enhancers” Panel of Experts at the 163rd American Psychiatric Association
Annual Meeting, May 22-26, 2010. New Orleans, LA.
“Modafinil Revisited”, A panel at the 48th ACNP Annual Meeting. December 6-10,
2009. The Westin Diplomat, Hollywood, Fl.
Caffeine: is the next problem already brewing? A 2-day, NIDA-ODS research agenda
setting expert symposium. July 7-8, 2009. Neuroscience Building, Bethesda, MD.
“Plastic Changes in the Addicted Brain: A Glimpse at the Next Generation of Pharmacotherapies” A panel at the 44th ACNP Annual meeting, December 11-15, 2005, Waikoloa HI “The biological clock: a timely update”. A panel, during the 36th Annual Winter Conference on Brain Research, January 26-31, 2003. Snowbird, UT. “The biological clock: of molecular gears, timing belts and post-transcriptional modifications”. A panel, during the 34th Annual Winter Conference on Brain Research, January 20-27, 2001. Steamboat, CO. “Targeted Tinkering: manipulating gene expression in the brain”, Interactive panel at the 33rd Annual Winter Conference on Brain Research, Jan 22-29, 2000, Breckenridge, CO..
11
“Building a biological clock out of molecular rhythms”, Interactive panel at the 30th Annual Winter Conference on Brain Research, Jan. 25 – Feb. 1, 1997. Breckenridge, CO. “Neurobiology of Fos Related Antigens”, NICHD-sponsored symposium at the Natcher Center; an ancillary meeting to the Society for Neuroscience Annual Meeting, November 21-22, 1996. Washington, DC.
PARTICIPACIÓN EN PROGRAMAS DE MEDIOS TELEVISIVOS
CADCA TV:
An hour-long program where viewers will learn about The Origins of Addiction, see
how the addicted brain changes over time and understand why treatment is often so
difficult.
Airing Jan. 31 2013
https://mctft.icfwebservices.com/webcasts/w.aspx?ID=635 CADCA TV: Dispelling Drug Myths,
An hour-long program where viewers hear the facts about drugs from experts who
dispel some of the big myths people hear and spread. Viewers also learned how to use
facts to get the word out via social norms campaigns and other fact-based methods.
April 5 2011
https://mctft.icfwebservices.com/webcasts/w.aspx?ID=617 NIDA on YOUTUBE: NIDA scientist Ruben Baler talks about the dangers and consequences of steroid abuse. English and Spanish versions. http://www.youtube.com/watch?v=z9Ynf2kPNIc NIDA for teens: Science For Starters: A Conversation with Dr. Ruben Baler, Ph.D.
http://teens.drugabuse.gov/blog/science-starters/
12
PEER-REVIEWED PUBLICATIONS
1. 1 Volkow ND, Hampson AJ, Baler R. Don't Worry, Be Happy: Endocannabinoids and
Cannabis at the Intersection of Stress and Reward. Annu Rev Pharmacol Toxicol. 2016
Sep 2.
2. Volkow ND, Swanson JM, Evins AE, et al. Effects of Cannabis Use on Human Behavior,
Including Cognition, Motivation, and Psychosis: A Review. JAMA Psychiatry. 2016 Mar
1;73(3):292-7.
3. Compton WM, Baler R. The Epidemiology of DSM-5 Cannabis Use Disorders Among
U.S. Adults: Science to Inform Clinicians Working in a Shifting Social Landscape. Am J
Psychiatry. 2016 Jun 1;173(6):551-3.
4. Volkow ND, Koob G, Baler R. Biomarkers in Substance Use Disorders. ACS Chem
Neurosci. 2015 Mar 18.
5. Volkow ND, Baler RD. NOW vs LATER brain circuits: implications for obesity and
addiction. Trends Neurosci. 2015 Jun;38(6):345-52.
6. Volkow ND, Baler R. Beliefs modulate the effects of drugs on the human brain. Proc
Natl Acad Sci U S A. 2015 Feb 24;112(8):2301-2.
7. Kravitz AV, Tomasi D, LeBlanc KH, et al. Cortico-striatal Circuits: Novel therapeutic
Targets for substance use Disorders. Brain Res. 2015 Apr 8.
8. Volkow ND, Baler RD, Compton WM, Weiss SR. Adverse health effects of marijuana
use. N Engl J Med. 2014 Jun 5;370(23):2219-27.
9. Volkow ND, Baler RD. Addiction science: Uncovering neurobiological complexity.
Neuropharmacology. 2014 Jan;76 Pt B:235-49.
10. Volkow ND, Baler RD. Foreword. Substance use and abuse among adolescents. Adolesc
Med State Art Rev. 2014 Apr;25(1):xv-xvi.
11. Volkow ND, Wang GJ, Tomasi D, Baler RD. Obesity and addiction: neurobiological
overlaps. Obes Rev. 2013 Jan;14(1):2-18.
12. Volkow ND, Wang GJ, Tomasi D, Baler RD. The addictive dimensionality of obesity. Biol
Psychiatry. 2013 May 1;73(9):811-8.
13. Volkow ND, Wang GJ, Tomasi D, Baler RD. Unbalanced neuronal circuits in addiction.
Curr Opin Neurobiol. 2013 Feb 21.
14. Volkow ND, Baler RD. Brain imaging biomarkers to predict relapse in alcohol addiction.
JAMA Psychiatry. 2013 Jul 1;70(7):661-3.
15. Volkow ND, Baler RD. Addiction science: Uncovering neurobiological complexity.
Neuropharmacology. 2013 May 18.
16. Volkow ND, Baler RD. Neuroscience. To stop or not to stop? Science. 2012 Feb
3;335(6068):546-8.
17. Volkow ND, Wang GJ, Fowler JS, Tomasi D, Baler R. Food and Drug Reward:
Overlapping Circuits in Human Obesity and Addiction. Curr Top Behav Neurosci. 2011
Oct 21.
18. Volkow ND, Baler RD, Normand JL. The Unrealized Potential of Addiction Science in
Curbing the HIV Epidemic. Curr HIV Res. 2011 Sep 1;9(6):393-5.
13
19. Volkow ND, Baler RD, Goldstein RZ. Addiction: pulling at the neural threads of social
behaviors. Neuron. 2011 Feb 24;69(4):599-602.
20. Baler RD, Volkow ND. Addiction as a systems failure: focus on adolescence and
smoking. J Am Acad Child Adolesc Psychiatry. 2011 Apr;50(4):329-39.
21. Volkow ND, Wang GJ, Fowler JS, Tomasi D, Telang F, Baler R. Addiction: decreased
reward sensitivity and increased expectation sensitivity conspire to overwhelm the
brain's control circuit. Bioessays. 2010 Sep;32(9):748-55.
22. Volkow ND, Wang GJ, Baler RD. Reward, dopamine and the control of food intake:
implications for obesity. Trends Cogn Sci. 2010 Jan;15(1):37-46.
23. Swanson J, Baler RD, Volkow ND. Understanding the effects of stimulant medications
on cognition in individuals with attention-deficit hyperactivity disorder: a decade of
progress. Neuropsychopharmacology. 2010 Jan;36(1):207-26.
24. Arima H, Baler R, Aguilera G. Fos proteins are not prerequisite for osmotic induction of
vasopressin transcription in supraoptic nucleus of rats. Neurosci Lett. 2010 Dec
3;486(1):5-9.
25. Volkow ND, Fowler JS, Wang GJ, Baler R, Telang F. Imaging dopamine's role in drug
abuse and addiction. Neuropharmacology. 2009;56 Suppl 1:3-8.
26. Ferre S, Baler R, Bouvier M, et al. Building a new conceptual framework for receptor
heteromers. Nat Chem Biol. 2009 Mar;5(3):131-4.
27. Bailey MJ, Coon SL, Carter DA, et al. Night/day changes in pineal expression of >600
genes: central role of adrenergic/cAMP signaling. J Biol Chem. 2009 Mar
20;284(12):7606-22.
28. Volkow N, Rutter J, Pollock JD, Shurtleff D, Baler R. One SNP linked to two diseases-
addiction and cancer: a double whammy? Nicotine addiction and lung cancer
susceptibility. Mol Psychiatry. 2008 Nov;13(11):990-2.
29. Baler RD, Volkow ND, Fowler JS, Benveniste H. Is fetal brain monoamine oxidase
inhibition the missing link between maternal smoking and conduct disorders? J
Psychiatry Neurosci. 2008 May;33(3):187-95.
30. Li TK, Volkow ND, Baler RD, Egli M. The biological bases of nicotine and alcohol co-
addiction. Biol Psychiatry. 2007 Jan 1;61(1):1-3.
31. Humphries A, Wells T, Baler R, Klein DC, Carter DA. Rodent Aanat: intronic E-box
sequences control tissue specificity but not rhythmic expression in the pineal gland.
Mol Cell Endocrinol. 2007 May 30;270(1-2):43-9.
32. Munoz E, Brewer M, Baler R. Modulation of BMAL/CLOCK/E-Box complex activity by a
CT-rich cis-acting element. Mol Cell Endocrinol. 2006 Jun 27;252(1-2):74-81.
33. Baler RD, Volkow ND. Drug addiction: the neurobiology of disrupted self-control.
Trends Mol Med. 2006 Dec;12(12):559-66.
34. Anzulovich A, Mir A, Brewer M, Ferreyra G, Vinson C, Baler R. Elovl3: a model gene to
dissect homeostatic links between the circadian clock and nutritional status. J Lipid
Res. 2006 Dec;47(12):2690-700.
35. Brewer M, Lange D, Baler R, Anzulovich A. SREBP-1 as a transcriptional integrator of
circadian and nutritional cues in the liver. J Biol Rhythms. 2005 Jun;20(3):195-205.
36. Appelbaum L, Anzulovich A, Baler R, Gothilf Y. Homeobox-clock protein interaction in
zebrafish. A shared mechanism for pineal-specific and circadian gene expression. J Biol
Chem. 2005 Mar 25;280(12):11544-51.
37. Marquez S, Crespo P, Carlini V, et al. The metabolism of phospholipids oscillates
rhythmically in cultures of fibroblasts and is regulated by the clock protein PERIOD 1.
Faseb J. 2004 Mar;18(3):519-21.
14
38. Humphries A, Weller J, Klein D, Baler R, Carter DA. NGFI-B (Nurr77/Nr4a1) orphan
nuclear receptor in rat pinealocytes: circadian expression involves an adrenergic-cyclic
AMP mechanism. J Neurochem. 2004 Nov;91(4):946-55.
39. Appelbaum L, Toyama R, Dawid IB, Klein DC, Baler R, Gothilf Y. Zebrafish serotonin-N-
acetyltransferase-2 gene regulation: pineal-restrictive downstream module contains a
functional E-box and three photoreceptor conserved elements. Mol Endocrinol. 2004
May;18(5):1210-21.
40. Munoz E, Baler R. The circadian E-box: when perfect is not good enough. Chronobiol
Int. 2003 May;20(3):371-88.
41. Munoz E, Brewer M, Baler R. Circadian Transcription. Thinking outside the E-Box. J Biol
Chem. 2002 Sep 27;277(39):36009-17.
42. Humphries A, Klein D, Baler R, Carter DA. cDNA array analysis of pineal gene
expression reveals circadian rhythmicity of the dominant negative helix-loop-helix
protein-encoding gene, Id-1. J Neuroendocrinol. 2002 Feb;14(2):101-8.
43. Smith M, Burke Z, Humphries A, et al. Tissue-specific transgenic knockdown of Fos-
related antigen 2 (Fra-2) expression mediated by dominant negative Fra-2. Mol Cell
Biol. 2001 Jun;21(11):3704-13.
44. Baler R. Clockless yeast and the gears of the clock: how do they mesh? J Biol Rhythms.
2001 Dec;16(6):516-22.
45. Schwartz WJ, Carpino A, Jr., de la Iglesia HO, et al. Differential regulation of fos family
genes in the ventrolateral and dorsomedial subdivisions of the rat suprachiasmatic
nucleus. Neuroscience. 2000;98(3):535-47.
46. Chen W, Baler R. The rat arylalkylamine N-acetyltransferase E-box: differential use in a
master vs. a slave oscillator. Brain Res Mol Brain Res. 2000 Sep 30;81(1-2):43-50.
47. Burke ZD, Wells T, Carter DA, Baler R. Use of a cryptic splice donor site in the
chloramphenicol acetyltransferase (CAT)-SV40 small-t antigen cassette generates
alternative transcripts in transgenic rats. Transgenic Res. 2000 Feb;9(1):67-70.
48. Burke Z, Wells T, Carter D, Klein D, Baler R. Genetic targeting: the serotonin N-
acetyltransferase promoter imparts circadian expression selectively in the pineal gland
and retina of transgenic rats. J Neurochem. 1999 Oct;73(4):1343-9.
49. Baler R, Covington S, Klein DC. Rat arylalkylamine N-acetyltransferase gene: upstream
and intronic components of a bipartite promoter. Biol Cell. 1999 Dec;91(9):699-705.
50. Klein DC, Coon SL, Roseboom PH, et al. The melatonin rhythm-generating enzyme:
molecular regulation of serotonin N-acetyltransferase in the pineal gland. Recent Prog
Horm Res. 1997;52:307-57; discussion 57-8.
51. Baler R, Covington S, Klein DC. The rat arylalkylamine N-acetyltransferase gene
promoter. cAMP activation via a cAMP-responsive element-CCAAT complex. J Biol
Chem. 1997 Mar 14;272(11):6979-85.
52. Roseboom PH, Coon SL, Baler R, McCune SK, Weller JL, Klein DC. Melatonin synthesis:
analysis of the more than 150-fold nocturnal increase in serotonin N-acetyltransferase
messenger ribonucleic acid in the rat pineal gland. Endocrinology. 1996
Jul;137(7):3033-45.
53. Baler R, Zou J, Voellmy R. Evidence for a role of Hsp70 in the regulation of the heat
shock response in mammalian cells. Cell Stress Chaperones. 1996 Apr;1(1):33-9.
54. Baler R, Coon S, Klein DC. Orphan nuclear receptor RZRbeta: cyclic AMP regulates
expression in the pineal gland. Biochem Biophys . Res Commun. 1996 Mar
27;220(3):975-8.
15
55. Coon SL, Roseboom PH, Baler R, et al. Pineal serotonin N-acetyltransferase: expression
cloning and molecular analysis. Science. 1995 Dec 8; 270(5242):1681-3.
56. Baler R, Klein DC. Circadian expression of transcription factor Fra-2 in the rat pineal
gland. J Biol Chem. 1995 Nov 10;270(45):27319-25.
57. Zuo J, Baler R, Dahl G, Voellmy R. Activation of the DNA-binding ability of human heat
shock transcription factor 1 may involve the transition from an intramolecular to an
intermolecular triple-stranded coiled-coil structure. Mol. Cell Biol. 1994 Nov;
14(11):7557-68.
58. Baler R, Dahl G, Voellmy R. Activation of human heat shock genes is accompanied by
oligomerization, modification, and rapid translocation of heat shock transcription
factor HSF1. Mol Cell Biol. 1993 Apr;13(4):2486-96.
59. Ananthan J, Baler R, Morrissey D, et al. Synergistic activation of transcription is
mediated by the N-terminal domain of Drosophila fushi tarazu homeoprotein and can
occur without DNA binding by the protein. Mol Cell Biol. 1993 Mar;13(3):1599-609.
60. Baler R, Welch WJ, Voellmy R. Heat shock gene regulation by nascent polypeptides and
denatured proteins: hsp70 as a potential autoregulatory factor. J Cell Biol. 1992 Jun;
117(6):1151-9.
61. Codias EK, Cray C, Baler RD, Levy RB, Malek TR. Expression of Ly-6A/E alloantigens in
thymocyte and T-lymphocyte subsets: variability related to the Ly-6a and Ly-6b
haplotypes. Immunogenetics. 1989;29(2):98-107.
62. Goldenberg CJ, Luo Y, Fenna M, Baler R, Weinmann R, Voellmy R. Purified human
factor activates heat shock promoter in a HeLa cell-free transcription system. J Biol
Chem. 1988 Dec 25; 263(36):19734-9.
63. Alito AE, Romeo HE, Baler R, Chuluyan HE, Braun M, Cardinali DP. Autonomic nervous
system regulation of murine immune responses as assessed by local surgical
sympathetic and parasympathetic denervation.
Acta Physiol Pharmacol Latinoam. 1987; 37(3):305-19.
64. Tarcic N, Baler R, Naor D. Auto-delayed-type hypersensitivity induced in
immunodeficient mice with modified self-antigens. III. Suppressive T-cell factor
controls the autoreactivity against self-antigens. Scand J Immunol.
1984 Nov; 20(5): 389-401.