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Curriculum Vitae: Peng Chen

Department of Chemistry and Chemical Biology Cornell University, Ithaca, NY 14853

607-254-8533 (office), 607-255-4137 (fax) pc252@cornell.edu, http://www.chem.cornell.edu/pc252/

Professional Appointments 2005- Assistant Professor, Department of Chemistry and Chemical Biology, Cornell University

Education and Training 2004-2005 Postdoctoral Fellow, Chemistry, Harvard University Advisor: Prof. X. Sunney Xie Field: Single Molecule Biophysics 1998-2003 Ph.D., Chemistry, Stanford University Advisor: Prof. Edward I. Solomon Field: Bioinorganic/Physical Inorganic Chemistry

Thesis Title: “Spectroscopic Definition of Electronic Structure Contributions to O2 and N2O Activation by Mononuclear, Binuclear, and Tetranuclear Copper Sites in Biology”

1997-1998 Graduate Research Assistant, Chemistry, University of California, San Diego Advisor: Prof. Yitzhak Tor Field: Organic Chemistry 1993-1997 B.S., Chemistry, Nanjing University, China Bachelor thesis advisor: Prof. Jianyi Shen Field: Physical Chemistry

Honor and Award 2010 Paul D. Saltman Memorial Award, GRC Metals in Biology 2009 Alfred P. Sloan Research Fellow 2007 NSF Career Award 2005 Camille and Henry Dreyfus New Faculty Award 2002-2003 Franklin Veatch Memorial Fellowship, Stanford University 2001 10th International Conference on Bioinorganic Chemistry Young Scientists Grant, Italy 1999-2002 Gerhard Casper Stanford Graduate Fellowship, Stanford University 1996 GuangHua Award, Nanjing University, China 1994 YinSong Award, Nanjing University, China 1993-1997 People Award, Nanjing University, China 1993-1997 Excellent Student Honor, Nanjing University, China 1992 First-rank Prize, National Chemistry Competition, China 1992 First-rank Prize, Jiangsu Province Chemistry Competition, China

Honorary Lectures 2012 Plenary Lecturer, 4th International Congress on Operando Spectroscopy 2010 Keynote Speaker, Lorentz-Workshop in Leiden, the Netherlands; Seeing Enzymes in Action 2010 Headline Invited Speaker, Faraday Discussion Meeting: Spectroscopy, Theory and Mechanism in

Bioinorganic Chemistry 2010 Keynote Speaker, Chemical Biophysics Symposium, University of Toronto 2008 Plenary Speaker, International Copper Meeting: Copper and Related Metals in Biology

Current Research Interests • Single-molecule nanocatalysis: catalysis and electrocatalysis by nanoscale materials • Single-molecule bioinorganic chemistry: biomolecule dynamics for metal transport and regulation

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Professional Activities

Professional Affiliations American Chemical Society, Society of Biological Inorganic Chemistry

Journal Referee Services Nature, Science, Proceedings of the National Academy of Sciences U.S.A., Journal of the American Chemical Society, Inorganic Chemistry, Journal of Physical Chemistry, Physical Chemistry Chemical Physics, Biophysical Journal, Journal of the Biological Inorganic Chemistry, Langmuir, Metallomics, Journal of Materials Chemistry

Grant Referee Services • Ad hoc reviewer for: NSF, NIH, DOE, Petroleum Research Foundation, Research Corporation, Ohio

Cancer Research Associates • On-site panel reviewer of the catalysis program at Lawrence Berkeley National Laboratory, 2011 • NIH/NIGMS Minority Biomedical Research (MBRS) program panel, 2010 • NSF Graduate Fellowship review panel, 2007

Cornell University & Departmental Services Molecular Biophysics Training Grant Chemistry-Biology Interface Training Grant Computing Committee, Chem & Chem Bio, 2005-2007 Graduate Program Committee, Chem & Chem Bio, 2006-2010 Instructional Equipments Committee, Chem & Chem Bio, 2005-2006 Lectures & Seminar Committee, Chem & Chem Bio, 2006-2010; Chair 2010- MISP Fellows, 2009-2010 Undergraduate Work Award Committee, 2005-2008 Wachter Prize Committee, 2006-2010 Website Committee, 2007-2010 Student Award Committee, 2010-; Chair 2010-

Teaching Chem 686, Physical Chemistry of Proteins: fall 2005, fall 2006, fall 2007, fall 2008, spring 2011 Chem 288, Introductory Physical Chemistry: spring 2007, spring 2008, spring 2009 Chem 2090, Engineering General Chemistry: fall 2009 BioBM 836, Methods & Logic in Biochemistry, Molecular and Cell Biology I: guest lectures, spring of 2008 and 2009.

Invited University/Government Lab Seminars (Since July 2005) 1. Frontiers in Biophysics, Cornell University, September 17, 2005 2. Cornell Biophysics Colloquium, September 20, 2006 3. Nanobiotechnology Center, Cornell University, February 20, 2007 4. Department of Chemistry, Bowling Green State University, September 12, 2007 5. Department of Chemistry, Dartmouth College, September 27, 2007 6. Department of Biochemistry, University at Buffalo, October 9, 2007 7. Department of Chemistry, University of California at Irvine, February 12, 2008 8. Department of Biochemistry, Duke University, October 3, 2008 9. Department of Chemistry, University of North Carolina at Chapel Hill, October 22, 2008 10. Department of Chemistry, University of Rochester, October 27, 2008 11. Laboratory of Atomic and Solid State Physics, Department of Physics, Cornell University, February 3,

2009

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12. Department of Chemistry, University of Pennsylvania, February 26, 2009 13. Department of Chemistry, Massachusetts Institute of Technology, March 17, 2009 14. Department of Chemistry, University of California at Berkeley, March 19, 2009 15. Nanoscience and Engineer Center, Columbia University, April 1, 2009 16. Department of Chemistry, University of Virginia, September 11, 2009 17. Department of Chemistry, Tufts University, September 15, 2009 18. Department of Chemistry, California Institute of Technology, October 5, 2009 19. Department of Chemistry and Biochemistry, University of California at Santa Barbara, October 7,

2009 20. Department of Chemistry, University of California at Riverside, October 8, 2009 21. Center for Nanotechnology, University of Washington, Seattle, October 13, 2009 22. Department of Chemistry, Stanford University, October 27, 2009 23. Department of Chemistry, Yale University, January 19, 2010 24. Department of Chemistry, Colorado State University, February 11, 2010 25. Department of Chemistry and Biochemistry, University of Colorado, February 12, 2010 26. Department of Materials Science and Engineering, Northwestern University, February 23, 2010 27. Department of Chemistry, Northwestern University, February 24, 2010 28. Department of Chemical Engineering, Case Western Reserve University, February 25, 2010. 29. Department of Chemistry, Texas A & M University, March 2, 2010 30. Department of Chemistry and Biochemistry, University of Texas at Austin, March 4, 2010 31. Department of Chemistry, Michigan State University, March 8, 2010 32. Department of Chemistry, University of Michigan, March 9, 2010 33. National Institute of Standard and Technology, March 25, 2010 34. Department of Chemistry, Georgia State University, March 26, 2010 35. School of Chemistry and Biochemistry, Georgia Institute of Technology, March 30, 2010 36. Department of Chemistry, University of Illinois at Urbana-Champaign, April 15, 2010 37. Department of Chemistry, University of Chicago, April 16, 2010 38. Department of Chemistry, Princeton University, April 27, 2010 39. Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology,

Japan, June 1, 2010 40. Department of Chemistry, Ibaraki University, Japan, June 2, 2010 41. Department of Nanobiochemistry, Konan University, Japan, June 3, 2010 42. School of Chemistry and Chemical Engineering, Nanjing University, China, June 8, 2010 43. Department of Chemistry, Shanghai Normal University, China, June 10, 2010 44. Frontiers in Biophysics, Cornell University, September 18, 2010 45. Department of Chemistry, Indiana University, October 15, 2010 46. Department of Chemistry and Chemical Biology, Cornell University, October 28, 2010 47. Department of Chemistry, Group of Inorganic Chemistry and Catalysis, Utrecht University, the

Netherlands, November 2, 2010 48. Center for Nanoscale Materials, Argonne National Laboratory, December 8, 2010 49. Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, April 6,

2011 50. Department of Chemistry, National Tsing Hua University, Taiwan, June 22, 2011 51. Department of Chemistry, National Taiwan University, Taiwan, June 23, 2011 52. Department of Applied Chemistry, National Chiao Tung University, Taiwan, June 24, 2011

Invited Conference Talks (Since July 2005) 1. Young Academic Investigators Symposium, Division of Biological Chemistry, 235th ACS National

Meeting, New Orleans, LA, April 2008

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Probing Real-Time Transient Protein Interactions at the Single-Molecule Level with Nanovesicle Trapping

2. George Fisher Baker Symposium in Frontiers in Biophysical Chemistry: Single Molecules and Metal Ions; Cornell University, Ithaca, NY, September 12-13, 2008 Single-Molecule Dynamics of Metal Transporters, Regulators, and Nanoparticles

3. Plenary talk. International Copper Meeting: Copper and Related Metals in Biology; Alghero, Sardinia, Italy, October 11-15, 2008 Watching the Actions of Copper Transporters One Molecule at A Time

4. Helios Solar Energy Research Center Meeting, Lawrence Berkeley National Laboratory, University of California at Berkeley, November 21, 2008 Single-Molecule Imaging of Nanoscale Catalysis and Electrocatalysis

5. Cornell Center for Materials Research Members meeting, December 10, 2008 Single-Molecule Imaging of Nanoscale Catalysis and Electrocatalysis

6. Gordon Research Conference: Chemical Reactions at Surfaces; Ventura, CA; February 8-13, 2009; Short Hot Topic Talk Real-Time Imaging of Nanoparticle Surface Reactions at Single-Particle Single-Turnover Resolution

7. Symposium S: Materials in Photocatalysis and Photoelectrochemistry for Environmental Applications and H2. MRS Spring Meeting, San Francisco, April 13-17, 2009. Probing Single Nanoparticle Catalysis at Single-Turnover Resolution.

8. Gordon Research Conference: Clusters, Nanocrystals & Nanostructures; Mount Holyoke College, South Hadley, MA; July 19-24, 2009 Single-Molecule Imaging of Single Nanoparticle Catalysis

9. 14th International Conference on Biological Inorganic Chemistry (ICBIC14), Nagoya, Japan, July 25-30, 2009 Single-Molecule Dynamics of Metal Regulators and Transporters

10. 2nd International Symposium on Bioinorganic Chemistry of the New Era & 22nd Meeting of Bioinorganic Chemistry Discussion Group, Takayama, Japan, July 31 – August 2, 2009 Single-Molecule Dynamics of Metal Nanoparticles, Regulators, and Transporters

11. Symposium on “The Physical Chemistry of Photon to Fuel Conversion,” Division of Physical Chemistry, 238th ACS National Meeting, Washington, D.C.; August 16-20, 2009 Real-Time In-Situ Imaging of Nanocatalysis at the Single-Molecule Level

12. Paul Saltman Award Lecture, Gordon Research Conference: Metals in Biology; Ventura, CA; January 31 - February 5, 2010 Visualizing Metal Transporter and Regulator Dynamics at the Single-Molecule Level

13. Keynote speaker, Chemical Biophysics Symposium, University of Toronto, Canada; April 9-11, 2010 Single-Molecule Dynamics of Metal Regulators and Nanocatalysts

14. 5th Sino-US Nano Forum, Suzhou, China; June 5-7, 2010 Single-Molecule Nanocatalysis

15. Gordon Research Conference: Noble Metal Nanoparticles; Mount Holyoke College, MA; June 20-25, 2010 Single-Molecule Nanocatalysis

16. Headline invited speaker, Faraday Discussion Meeting: Spectroscopy, Theory and Mechanism in Bioinorganic Chemistry; University of Nottingham, UK; July 5-7, 2010 Relating Dynamic Protein Interactions of Metallochaperones with Metal Transfer at the Single-Molecule Level

17. Cluster-Surface Interactions workshop, Stratford-on-Avon, UK; July 5-8, 2010 Single-Nanoparticle Catalysis at Single-Turnover Resolution

18. Symposium on Metalloproteins, 24th Annual Symposium of the Protein Society, San Diego, CA; August 1-5, 2010 Single-Molecule Dynamics of Metal Regulators and Transporters

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19. Symposium on “Nano Letters: The Next Ten Years”, Division of Colloidal and Surface Science, ACS National Meeting, Boston, MA; August 22-26, 2010 Single-Molecule Nanocatalysis

20. Symposium on “Metals in Biology,” Division of Physical Chemistry, ACS National Meeting, Boston, MA; August 22-26, 2010

Single-Molecule Dynamics of Metal Regulators and Transporters 21. 57th American Vacuum Society International Symposium, Albuquerque, NM; October 17-20, 2010

Single-Nanoparticle Catalysis at Single-Turnover Resolution 22. Keynote speaker, Lorentz workshop on "Seeing proteins in action", Leiden, The Netherlands;

November 1-5, 2010 Single-Molecule Catalysis: Beyond Enzymes 23. 3rd Georgian Bay International Conference on Bioinorganic Chemistry, Parry Sound, Ontario,

Canada, May 31 – June 3, 2011 24. 7th Sino-US Chemistry Professors Conference (SINO-US-7), Guiyang, China, June 27-30, 2011 25. Plenary lecture, 4th International Congress on Operando Spectroscopy, Recent Developments and

Future Perspectives in Spectroscopy of Working Catalysts; Brookhaven National Laboratory, Upton, NY; April 29 - May 3, 2012

Contributed Conference Talks (Since July 2005) 1. 13th International Conference on Biological Inorganic Chemistry (ICBIC13), Vienna, Austria, July

2007 Single-Molecule Study of Dynamics and Mechanism of Metal Transport and Metal Regulation

2. Symposium of Single Molecule Spectroscopy, Imaging and Manipulation of Biomolecular Systems, 234th ACS National Meeting, Boston, MA, August 2007 Engineered Holliday Junctions as Single-Molecule Reporters for Protein-DNA Interactions

3. Division of Inorganic Chemistry: Bioinorganic Chemistry: DNA and RNA, 235th ACS National Meeting, New Orleans, LA, April 2008 Probing Metalloregulator-DNA Interactions at the Single-Molecule Level with Engineered Holliday Junctions

4. Division of Physical Chemistry: Nanostructured Materials, 235th ACS National Meeting, New Orleans, LA, April 2008 Probing the Catalytic Activity of Nanoparticles at the Single-Molecule Level

5. NSF Workshop in Inorganic Chemistry, Virginia Beach, VA, June 2008 Probing the Catalytic Activity of Nanoparticles at the Single-Molecule Level

6. Convergence between Theory and Experiment in Surface Chemistry and Catalysis, 237th ACS National Meeting, Salt Lake City, UT, March 2009 Single-Molecule Dynamics of Nanocatalysis

7. Novel Catalytic Imaging Techniques; AICHE National Meeting, Nashville, TN, November 2009 Single-Molecule Imaging of Nanoscale Catalysis

8. Nanotubes and Related Nanostructures: Electronic Properties and Application I, MRS Fall Meeting, Boston, MA, December 2009 Single-Molecule Imaging of Electron-to-Fuel Conversion by Single-Walled Carbon Nanotubes

9. Catalytic Materials for Energy, Green Processes, and Nanotechnology, MRS Fall Meeting, Boston, MA, December 2009 In-Situ Optical Imaging of Single Nanoparticle Catalysis at Single-Turnover Resolution

Publications (Graduate & Postdoctoral) 1. Peng Chen, Kiyoshi Fujisawa, Edward I. Solomon

“Spectroscopic and Theoretical Studies of Mononuclear Copper(II) Alkyl- and Hydroperoxo Complexes: Electronic Structure Contributions to Reactivity”

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J. Am. Chem. Soc. 2000, 122, 10177-10193.

2. Edward I. Solomon, Peng Chen, Markus Metz, Sang-Kyu Lee, Amy E. Palmer “Oxygen Binding, Activation and Reduction to Water by Copper Proteins” Angew. Chem. Int. Ed. 2001, 40, 4570-4590; Angew. Chem. 2001, 113, 4702-4724.

3. Peng Chen, Inês Cabrito, William E. Antholine, Isabel Moura, José J. G. Moura, Edward I. Solomon “Spectroscopic Studies of the CuZ Center of Nitrous Oxide Reductase” J. Inorg. Biochem. (ICBIC10 Issue) 2001, 86, 177.

4. Peng Chen, Edward I. Solomon “Frontier Molecular Orbital Analysis of Cun−O2 Reactivity” J. Inorg. Biochem. 2002, 88, 368-374. Invited 30th Anniversary Issue.

5. Peng Chen, Serena D. George, Inês Cabrito, William E. Antholine, José J. G. Moura, Isabel Moura, Britt Hedman, Keith E. Hodgson, Edward I. Solomon “Electronic Structure Description of the μ4-Sulfide Bridged Tetranuclear CuZ Center in N2O Reductase” J. Am. Chem. Soc. 2002, 124, 744-745.

6. Peng Chen, Inês Cabrito, José J. G. Moura, Isabel Moura, Edward I. Solomon “Spectroscopic and Electronic Structure Studies of the μ4-Sulfide Bridged Tetranuclear CuZ Cluster in N2O Reductase: Molecular Insight into the Catalytic Mechanism” J. Am. Chem. Soc. 2002, 124, 10497-10507.

7. Peng Chen, David E. Root, Cecelia Campochiaro, Kiyoshi Fujisawa, Edward I. Solomon “Spectroscopic and Electronic Structure Studies of the Diamagnetic Side-On CuII-Superoxo Complex Cu(O2)[HB(3-R-5-iPrpz)3]: Antiferromagnetic Coupling versus Covalent Delocalization” J. Am. Chem. Soc. 2003, 125, 466-474.

8. Matthew E. Helton, Peng Chen, Partha P. Paul, Zoltán Tyeklár, Roger Sommer, Lev Zhakarov, Arnold L. Rheingold, Edward I. Solomon, Kenneth D. Karlin “Reaction of Elemental Sulfur with a Copper(I) Complex Forming a trans-μ-1,2 End-On Disulfide Complex: New Directions in Copper-Sulfide Chemistry” J. Am. Chem. Soc. 2003, 125, 1160-1161.

9. Peng Chen, Kiyoshi Fujisawa, Matthew E. Helton, Kenneth D. Karlin, Edward I. Solomon “Spectroscopy and Bonding in Side-On and End-On Cu2(S2) Cores: Comparison to Peroxide Analogues” J. Am. Chem. Soc. 2003, 125, 6394-6408.

10. Somdatta Ghosh, Sergey I. Gorelsky, Peng Chen, Inês Cabrito, José J. G. Moura, Isabel Moura, Edward I. Solomon “Activation of N2O Reduction by the Fully Reduced μ4-Sulfide Bridged Tetranuclear CuZ Cluster in Nitrous Oxide Reductase” J. Am. Chem. Soc. 2003, 125, 15708-15709.

11. Peng Chen, Joseph Bell, Betty A. Eipper, Edward I. Solomon

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“Oxygen Activation by the Non-Coupled Binuclear Copper Site in Peptidylglycine α-Hydroxylating Monooxygenase: Spectroscopic Definition of the Resting Sites and the Putative CuII

M-OOH Intermediate” Biochemistry 2004, 43, 5735-5747.

12. Peng Chen, Edward I. Solomon “Oxygen Activation by the Non-Coupled Binuclear Copper Site in Peptidylglycine α-Hydroxylating Monooxygenase: Reaction Mechanism and Role of the Non-Coupled Nature of the Active Site” J. Am. Chem. Soc. 2004, 126, 4991-5000.

13. Peng Chen, Serge I. Gorelsky, Somdatta Ghosh, Edward I. Solomon “N2O Reduction by the μ4-Sulfide Bridged Tetranuclear CuZ Cluster Active Site” Angew. Chem. Int. Ed. 2004, 43, 4132-4140.

14. Peng Chen, Edward I. Solomon “O2 Activation by Binuclear Cu Sites: Noncoupled versus Exchange Coupled Mechanism” Proc. Natl. Acad. Sci. USA 2004, 101, 13105-13110.

15. Edward I. Solomon, Lipika Basumallick, Peng Chen, Pierre Kennepohl “Variable Energy Photoelectron Spectroscopy: Electronic Structure and Electronic Relaxation” Coord. Chem. Rev. 2005, 249, 229-253. Invited Issue of Synchrotron Radiation in Inorganic and Bioinorganic Chemistry.

16. Xiaolin Nan, Peter A. Sims, Peng Chen, X. Sunney Xie “Observation of Individual Microtubule Motor Steps in Living Cells with Endocytosed Quantum Dots” J. Phys. Chem. B 2005, 109, 24220-24224.

Publications (at Cornell) 17. Susanta K. Sarkar, Nesha May Andoy, Jaime J. Benitez, Peng R. Chen, Jason S. Kong, Chuan He,

Peng Chen “Engineered Holliday Junctions as Single-Molecule Reporters for Protein-DNA Interactions with Application to MerR-Family Regulators” Journal of the American Chemical Society 2007, 129, 12461-12467.

18. Peng Chen, Nesha May Andoy “Single-Molecule Fluorescence Studies from A Bioinorganic Perspective” Inorganica Chimica Acta 2008, 361, 809-819. Invited contribution to the special issue in honor of Edward I. Solomon.

19. Jaime Benítez, Aaron Keller, Patrick Ochieng, Liliya Yatsunyk, David Huffman, Amy Rosenzweig, Peng Chen “Probing Transient Copper Chaperone−Wilson Disease Protein Interactions at the Single-Molecule Level with Nanovesicle Trapping” Journal of the American Chemical Society 2008, 130, 2446-2447. Correction: J. Am. Chem. Soc. 2009, 131, 871.

20. Weilin Xu, Jason S. Kong, Yun-Ting E. Yeh, Peng Chen “Single-Molecule Nanocatalysis Reveals Heterogeneous Reaction Pathways and Catalytic Dynamics” Nature Materials 2008, 7, 992-996.

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21. Peng Chen, Nesha May Andoy

“Single-Molecule Fluorescence Methods in Enzymology” Comprehensive Natural Products Chemistry II Chemistry and Biology; Mander, L., Lui, H.-W., Eds.; Elsevier: Oxford, 2010; Vol. 9; pp 751. Invited review.

22. Weilin Xu, Jason S. Kong, Peng Chen “Single-Molecule Kinetic Theory of Heterogeneous and Enzyme Catalysis” Journal of Physical Chemistry C 2009, 113, 2393-2404.

23. Weilin Xu, Jason S. Kong, Peng Chen “Probing the Catalytic Activity and Heterogeneity of Au-Nanoparticles at the Single-Molecule Level” Physical Chemistry Chemical Physics 2009, 11, 2767–2778.

24. Peng Chen, Weilin Xu, Xiaochun Zhou, Debashis Panda, Aleksandr Kalininskiy “Single-Nanoparticle Catalysis at Single-Turnover Resolution” Chemical Physics Letters 2009, 470, 151-157. Invited FRONTIERS article.

25. Weilin Xu, Hao Shen, Yoon Ji Kim, Xiaochun Zhou, Guokun Liu, Jiwoong Park, Peng Chen “Single-Molecule Electrocatalysis by Single-Walled Carbon Nanotubes” Nano Letters 2009, 9, 3968–3973.

26. Nesha May Andoy, Susanta K. Sarkar, Qi Wang, Jaime J. Benitez, Aleksandr Kalininskiy, Peng Chen “Single-Molecule Study of Metalloregulator CueR−DNA Interactions Using Engineered Holliday Junctions” Biophysical Journal, 2009, 97, 844-852.

27. Weilin Xu, Hao Shen, Guokun Liu, Peng Chen “Single-Molecule Kinetics of Nanoparticle Catalysis” Nano Research, 2009, 2, 911-922.

Invited review article.

28. Xiaochun Zhou, Weilin Xu, Guokun Liu, Debashis Panda, Peng Chen “Size Dependent Catalytic Activity and Dynamics of Gold Nanoparticles at the Single-Molecule Level” Journal of the American Chemical Society, 2010, 132, 138-146.

29. Jaime Benitez, Aaron Keller, Peng Chen “Nanovesicle Trapping for Studying Weak Protein−Protein Interactions by Single-Molecule FRET” Methods in Enzymology, 2010, 472, 41-60. Invited article to the special volume Single Molecule Tools: Fluorescence Based Approaches.

30. Peng Chen, Nesha May Andoy, Jaime Benitez, Aaron Keller, Debashis Panda, Feng Gao “Tackling Metal Regulation and Transport at the Single-Molecule Level”

Natural Product Reports, 2010, 27, 757-767. Invited review to the Metals in Cells themed issue.

31. Hao Shen, Weilin Xu, Peng Chen “Single-Molecule Nanoscale Electrocatalysis”

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Physical Chemistry Chemical Physics, 2010, 12, 6555-6563. Invited Perspective article.

32. Peng Chen, Xiaochun Zhou, Hao Shen, Nesha May Andoy, Eric Choudhary, Kyu-Sung Han, Guokun Liu, Weilin Meng

“Single-Molecule Fluorescence Imaging of Nanocatalytic Processes” Chemical Society Reviews, 2010, 39, 4560-4570.

Invited Tutorial Review to the themed issue: Understanding the chemistry of active sites in heterogeneous catalysis – Lessons from in-situ spectroscopy studies.

33. Jaime Benitez, Aaron Keller, David Huffman, Liliya Yatsunyk, Amy Rosenzweig, Peng Chen “Relating Dynamic Protein Interactions of Metallochaperones with Metal Transfer at the Single-Molecule Level”

Faraday Discussions, 2011, 148, 71-82. Invited contribution to special volume: Spectroscopy, Theory and Mechanism in Bioinorganic Chemistry.

34. Peng Chen “Why Nanoparticle Catalysts Are Special: A Dynamic Adaptation Model” Nature Chemistry, submitted. 35. Peng Chen “Studies of Single Particle Catalysts” Annual Review of Analytical Chemistry, in preparation.

Invited review article. 36. Peng Chen “Single-Molecule Metallobiochemistry: Metal Transporters and Metal Regulators” Biochemistry, in preparation.

Invited Current Topics article.

News Articles Featuring Our Research 1. “Scrutinizing Catalysts," by Mitch Jacoby, Chemical & Engineering New 2008, 86(46), 9. 2. "When a good nanoparticle goes bad," NSF press release, November 10, 2008. Featured on NSF main

website banner. 3. "New method can capture catalysis, one molecule at a time," by Bill Steele, Cornell Chronicle,

November 10, 2008. 4. "When a good nanoparticle goes bad," Cornell Center for Materials Research, November 10, 2008. 5. "Watching a Catalyst at Work" on New Energy and Fuel, November 21, 2008. 6. "Gold study 'could lead to smart catalysts being produced'" Gold News, November 11, 2008. 7. Chemistry Today (in Japanese), February 2009, page 12. 8. "Monitoring catalysis one particle at a time," Nanotechnology Alert, Jan 23, 2009, Frost & Sullivan. 9. "Single nanocatalyst behavior revealed" by Nina Notma, Chemistry World, February 18, 2009. 10. "Finding how carbon nanotubes work as catalysts could lead to cleaner fuels" by Bill Steele, Cornell

Chronicle, April 16, 2009. 11. "Catalytic behavior of SWCNTs scrutinized" by Nina Notma, Chemistry World Blog, April 20, 2009. 12. "Pinpointing catalytic reaction sites on carbon nanotube walls" by Michael Berger, Nanowerk, April

21, 2009. 13. "Single-Molecule Fluorescence Events Seen In Real Time" by Mitch Jacoby, Chemical &

Engineering News, 2009, 87(16), 38.

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Journal Covers Featuring Our Research

Collaborators, Postdoctoral Associates, and Students

Collaborators Ruma Banerjee (University of Michigan) David Erickson (Cornell University) Chuan He (University Chicago) David Huffman (Western Michigan University) Roger Loring (Cornell University) Timothy Machonkin (Whitman College) Jiwoong Park (Cornell University) Shu-Bing Qian (Cornell University) Amy Rosenzweig (Northwestern University) Abraham Stroock (Cornell University) Angela Hight Walker/Yonglin Liu (NIST) Peidong Yang (University of California, Berkeley) Eugene Zubarev (Rice University)

Postdoctoral Associates (Total 11) 2008- Xiaochun Zhou (Ph.D., Chinese Academy of Sciences) 2008- Guokun Liu (Ph.D., Xiamen University, China) 2009- Kyu-Sung Han (Ph.D., Korean Advanced Institute of Science and Technology) 2009- Rupa Sarkar (Ph.D., Jadavpur University, India) 2010- Chandra Joshi (Ph.D., Free University of Berlin, Germany) 2010- Nesha May Andoy (Ph.D., Cornell University) 2011- Tai-Yen Chen (Ph.D., Texas A & M University) 2006-2007 Susanta Sarkar (Ph.D., University of Oregon) 2007-2009 Weilin Xu (Ph.D., Chinese Academy of Sciences) 2008-2010 Feng Gao (Ph.D., University of Pennsylvania) 2008-2010 Debashis Panda (Ph.D., Indian Institute of Technology)

Graduate Students (Total 8) 2006- Aaron Keller (Chemistry)

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2008- Hao Shen (Chemistry) 2009- Eric Choudhary (Chemistry) 2010- Feng Yang (Chemistry) 2010- Ace Santiago (Chemistry) 2010- Danya Martell Smart (Chemistry) 2006-2008 Jason Kong (M.S., Chemistry) 2005-2010 Jaime Benitez (Ph.D., Chemistry) 2005-2010 Nesha May Andoy (Ph.D., Chemistry)

Undergraduate Students (Total 11) 2006-2007 Derek Klarin (Chemistry) 2006-2007 Yun-Ting Eric Yeh (Biochemistry) 2006 Stephen Hohwald (Chemical Engineering) 2008 Rita Medina (University of Puerto Rico) 2008 Aleksandr Kalininskiy (Biochemistry) 2009 Matthew Goldfogel (Whitman College) 2009 Montwaun Young (University of North Carolina, Wilmington) 2009-2010 Weilin Meng (Cornell University) 2010 Alec White (Whitman College) 2010 Hahn Chong (Columbia University) 2010 Kimberly Yeh (Cornell University)

Rotation Students and Other Researchers (Total 4) 2005 Zhengxi Huang (Ph.D., Chinese Academy of Sciences) 2005 Richa Dave (Tri-Institutional Program in Chemical Biology) 2006 Qi Wang (Biophysics) 2006 Nicholas Harbinson (Tri-Institutional Program in Chemical Biology)

Awards, Fellowships, and Traineeships Won by Advisees at Cornell

Graduate Students Nesha May Andoy Tunis Wentink Prize for Outstanding Academic and Research Performance, 2010 Jaime Benitez NIH Molecular Biophysics Traineeship, 2006-2009

Carl Storm Underrepresented Minority Fellowship, GRC, 2008 Eric Choudhary NSF IGERT Fellowship on Materials for a Sustainable Future, 2010-2012 Aaron Keller NIH Molecular Biophysics Traineeship, 2007-2009 Poster Award, Cell Biology of Metals Gordon Research Conference, 2009

Poster Award, Graduate Association of Chemistry poster session, 2010

Undergraduate Students Aleksandr Kalininskiy Hughes Scholar, 2008 Derek Klarin Hughes Scholar, 2006 Weilin Meng Hill Fellowship for Undergraduate Summer Research, 2010

Research Support Current Support New Faculty Award Chen (PI) $50,000 08/01/05 − 12/31/12 0.1 person-months The Camille and Henry Dreyfus Foundation (extended from 7/31/10) Single Molecule Bioinorganic Chemistry Major goal: To introduce single-molecule methods into the field of bioinorganic chemistry.

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CHE-0645392 Chen (PI) $555,000 05/01/07 – 04/30/12 1 person-month NSF CAREER: Bioinorganic Chemistry on a Single-Molecule Basis Major goal: To harness single-molecule fluorescence techniques to characterize the dynamics and functions of metalloenzyme tyrosinase and to understand the protein interactions and metal transfer of copper chaperones. 1R01GM082939 Chen (PI) $1,300,938 09/01/08 − 06/30/13 2.5 person-months NIH Single-Molecule Study of Dynamics and Mechanisms of Biomacromolecule Interactions for Metal Transport and Metal Regulation Major goal: To understand the dynamics and mechanisms of intracellular metal transport and metal regulation by harnessing current and developing novel single-molecule fluorescence methods. Sloan Research Fellowship Chen (PI) $50,000 09/16/09 − 09/15/11 0.1 person-months Alfred P. Sloan Foundation Single-Molecule Bioinorganic Chemistry and Single-Nanoparticle Catalysis Major Goal: To develop innovative single-molecule approaches to biological inorganic chemistry and nanoparticle catalysis. 56355-CH / W911NF0910232 Chen (PI) $505,561 06/01/09 − 05/31/13 1 person-month ARO Probing Nanoparticle Reactivity at the Single-Molecule Level Major goal: To understand the catalytic activity, heterogeneity, selectivity, and dynamics of gold nanoparticle catalysts. CBET-0851257 Chen (PI) $281,039 08/01/09 – 07/31/12 0.8 person-months NSF Single-Molecule Investigation of Nanocatalysis Major goal: To understand the structural basis of the heterogeneous reactivity of nanoparticle catalysts. 1R21EB009202 Erickson (PI) $410,040 05/16/10 – 05/15/12 0.2 person-months NIH ($119,248 to Chen) Optically Resonant Nanotweezers Major goal: To develop a new single molecule optical trapping and florescence resonant energy transfer technique to enable the study of weak protein-protein interactions. Co-PI: Peng Chen DE-FG02-10ER16199 Chen (PI) $480,000 09/01/10 – 08/31/13 1 person-month DOE Chemical Imaging of Single Metal Nanoparticle Catalysis Major goal: To develop super-resolution optical imaging methods to spatially resolve metal nanoparticle catalysis at nanometer resolution and to study the shape-controlled Pt-nanoparticles at the single-molecule level. Completed Support WDA2007-1 Chen (PI) $30,000 12/15/07 − 12/14/08 Wilson’s Disease Association

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Probing the Interactions of Wilson Disease Protein with Copper Chaperone Hah1 One Molecule at A Time Major goal: To use single-molecule methods to characterize the interaction dynamics between different constructs of Wilson disease protein and the copper chaperone Hah1. PRF 47918-G5 Chen (PI) $50,000 05/01/08 − 08/31/10 ACS Petroleum Research Foundation Single Au-Nanoparticle Catalysis at Single-Turnover Resolution Major goal: To develop a single-molecule fluorescence approach to detect the single catalytic turnovers of single Au-nanoparticles. Seed Grant Chen (co-PI) $186,000 05/01/08 − 04/30/10 Cornell Center for Materials Research ($163,989 to Chen) Single Nanoparticle Catalytic Dynamics Major goal: To experimentally and theoretically understand the catalytic dynamics of single nanoparticles at both low and high substrate concentrations, using a combination of fluorescence microscopy, microfluidics, and non-equilibrium statistical mechanics. Co-PIs: Roger Loring and Abraham Stroock