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CURRICULUM VITAE Natalie M. Zahr, Ph.D.

Stanford, CA, USA nzahr@stanford.edu

Education: 2005 Ph.D. in Anatomy and Neurobiology Boston University, Boston 2001 M.S. in Pharmacology Northeastern University, Boston 1997 B.A. in Philosophy University of California, Los Angeles Research Positions: 2013 - present Senior Scientist, Neuroscience Program SRI International, Menlo Park, CA 2008 - present Research Scientist, Department of Psychiatry & Behavioral Sciences Stanford University, Stanford, CA 2007 - 2013 Postdoctoral Fellow, Neuroscience Program SRI International, Menlo Park, CA Advisor: Dr. Adolf Pfefferbaum 2005 - 2008 Postdoctoral Fellow, Department of Psychiatry & Behavioral Sciences Stanford University, Stanford, CA Advisor: Dr. Edith Sullivan 2003 - 2005 Visiting Scholar, Physiology Department Northwestern University, Chicago, IL Advisor: Dr. Isabelle Mintz 2001 - 2003 Graduate Student, Anatomy and Neurobiology Department Boston University, Boston, MA Advisor: Dr. Isabelle Mintz 1998 - 2001 Graduate Student, Pharmaceutical Sciences Department Northeastern University, Boston, MA Advisor: Dr. Barbara Waszczak Teaching Positions (selected): Summer 2012/2013 Instructor, Neuroscience

UC Berkeley Extension UC Berkeley, Berkeley, CA Winter 2012 Instructor, Human Anatomy

UC Berkeley Extension UC Berkeley, Berkeley, CA Spring 2001 Teaching Assistant, Therapeutics I and II

Department of Pharmaceutical Sciences Northeastern University, Boston, MA

Spring 2000 Teaching Assistant, Anatomy and Physiology Department of Pharmaceutical Sciences Northeastern University, Boston, MA

Winter 2000 Teaching Assistant, Immunology Department of Pharmaceutical Sciences Northeastern University, Boston, MA

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NIH Funding Multiple-investigator U01 AA017347 09/01/12 – 08/31/17 Tracking HIV Infection and Alcohol Abuse CNS Comorbidity with Neuroimaging MPI: Adolf Pfefferbaum & Natalie M. Zahr National Institute on Alcohol Abuse and Alcoholism Co-investigator U01 AA013521 12/01/10 – 09/30/15 Integrative Neuroscience Initiative on Alcoholism: Imaging Core PI: Adolf Pfefferbaum National Institute on Alcohol Abuse and Alcoholism Other Funding R01 AA005965 06/01/07 – 06/30/12 CNS Deficits: Interaction of Age and Alcoholism PI: Adolf Pfefferbaum National Institute on Alcohol Abuse and Alcoholism R01 AA012388 02/15/11 – 01/31/16 Neuroimaging of Connectivity in Alcoholism MPI: Adolf Pfefferbaum & Edith V. Sullivan National Institute of Alcohol Abuse and Alcoholism U01 AA013521 02/15/07 – 06/30/08 Effects of Acute Alcohol Exposure on Rat Brain Metabolites Detected In Vivo Using MRS Integrative Neuroscience Initiative on Alcoholism PI: Dirk Mayer Pilot Grant National Institute on Alcohol Abuse and Alcoholism SRI International Research and Development Awards W32JUN 2010 Systemic evidence for inflammatory mechanisms in ethanol induced neurodegeneration W32KTS 2009 ALDA Effects on Ethanol Metabolism W32NBW 2011 In vivo MR markers of inflammation Professional Associations Society for Neuroscience Research Society on Alcoholism International Society on Magnetic Resonance in Medicine Society for Neuroimmune Pharmacology Peer-Reviewed Papers Sullivan EV, Zahr NM, Rohlfing T, Pfefferbaum A. Cognitive demands during quiet standing elicit truncal tremor in two frequency bands: Differential relations to tissue integrity of corticospinal tracts and cortical targets. Frontiers in Human Neuroscience in revision. Pfefferbaum A, Zahr NM, Mayer D, Rohlfing T, Sullivan EV. Rapid recovery from fiber tract disorganization following a 4-day alcohol binge. PlosOne in revision. Pfefferbaum A, Rosenbloom MJ, Chu W, Sassoon SA, Rohlfing T, Pohl KM, Zahr NM, Sullivan EV.  

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White matter microstructural recovery with abstinence and decline with relapse in alcoholism: A controlled longitudinal DTI study. Lancet Neurology. 2014. 1(3):202-212. Zahr NM, Alt C, Mayer D, Rohlfing T, Manning-Bog A, Luong R, Sullivan EV, Pfefferbaum A. In vivo MRI, MRS, and postmortem regional brain cytokine histochemistry biomarkers in a rodent model of Wernicke's Encephalopathy with glucose challenge. Experimental Neurology. 2014. 261:109-19. Pfefferbaum A, Ragosa DA, Rosenbloom MJ, Chu WW, Sassoon, SA, Kemper CA, Deresinski S, Rohlfing T, Zahr NM, Sullivan EV. Accelerated aging of selective brain structures in HIV Infection: A controlled, longitudinal MRI study. Neurobiology of Aging. 2014. 35(7):1755-68.

Zahr NM, Mayer D, Rohfling T, Sullivan EV, Pfefferbaum A. Imaging neuroinflammation? A perspective from MR Spectroscopy. Brain Pathology. 2014. 24(6): 654-64.

Zahr NM. Graphs of Brain Networks. Commentary for “The effects of alcohol on the nonhuman primate brain: A network science approach to neuroimaging.” Alcohol Clinical and Experimental Research. 2013. 37(11): 1813-5.

Zahr NM, Mayer D, Rohlfing T, Hsu OA, Vinco S, Orduna J, Luong R, Bell RL, Sullivan EV, Pfefferbaum A. Rat strain differences in brain structure and neurochemistry in response to binge alcohol. Psychopharmacology. 2014. 231(2): 429-45.

Zahr NM, Mayer D, Rohlfing T, Orduna J, Luong R, Sullivan EV, Pfefferbaum A. A mechanism of rapidly reversible cerebral ventricular enlargement independent of tissue atrophy. Neuropsychopharmacology. 2013. 38(6): 1121-9.

Zahr NM, Mayer D, Rohlfing T, Chanraud S, Gu M, Sullivan EV, Pfefferbaum A. The functional significance of an in vivo glutamate measure derived from Magnetic Resonance Spectroscopy: behavioral and physiological correlates in aging. Neurobiology of Aging. 2013. 34(4): 1265.76.

Gu M, Zahr NM, Spielman D, Sullivan EV, Pfefferbaum A, Mayer D. Quantification of glutamate and glutamine using CT-PRESS at 3T. NMR in Biomedicine. 2013. 26(2): 164-72.

Zahr NM, Harper CG, Kaufman KL. Clinical and pathological features of alcohol-related brain damage. Nature Reviews Neurology. 2011. 7(5): 284-94.

Zahr NM, Bell RL, Ringham HN, Sullivan EV, Witzmann FA, Pfefferbaum A. Ethanol-induced changes in the expression of proteins related to neurotransmission and metabolism in different regions of the rat brain. Pharmacology, Biochemistry, and Behavior. 2011. 99(3): 428-36.

Sullivan EV, Zahr NM, Rohlfing T, Pfefferbaum A. Fiber tracking functionally distinct components of the internal capsule. Neuropsychologia. 2010. 48(14): 4155-63.

Pitel AL, Zahr NM, Jackson K, Sassoon SA, Rosenbloom MJ, Pfefferbaum A, Sullivan EV. Signs of preclinical Wernicke's Encephalopathy and thiamine levels as predictors of neuropsychological deficits in alcoholism without Korsakoff's Syndrome. Neuropsychopharmacology. 2011. 36(3): 580-8.

Zahr NM, Pitel AL, Chanraud S, Sullivan EV. Contributions of studies on alcohol use disorders to understanding cerebellar function. Neuropsychology Reviews. 2010. 20(3): 280-9.

Zahr NM, Luong R, Sullivan EV, Pfefferbaum A. Measurement of serum, liver, and brain cytokine induction, thiamine Levels, and hepatopathology in rats exposed to a 4-Day binge protocol. Alcohol Clinical and Experimental Research. 2010. 34(11): 1-13.

Zahr NM, Mayer D, Rohlfing T, Hasak M, Hsu O, Vinco S, Orduna J, Luong R, Sullivan EV, Pfefferbaum A. Brain injury and recovery following binge ethanol: evidence from in vivo magnetic resonance spectroscopy. Biological Psychiatry. 2010. 67(9): 846-54.

Chanraud S, Zahr NM, Sullivan EV, Pfefferbaum A. MR Diffusion Tensor Imaging: A window into

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white matter integrity of the working brain. Neuropsychology Reviews. 2010. 20(2): 209-25.

Rohlfing T, Zahr NM, Sullivan EV, Pfefferbaum A. The SRI24 multi-channel atlas of normal adult human brain structure. Human Brain Mapping. 2010. 31(5): 798-819.

Zahr NM, Crawford EL, Hsu O, Vinco S, Mayer D, Rohlfing T, Sullivan EV, Pfefferbaum A. In vivo glutamate decline associated with kainic-acid induced status epilepticus. Brain Research. 2009. 1300: 65-78.

Rohlfing T, Zahr NM, Sullivan EV, Pfefferbaum A. The SRI24 multi-channel brain atlas: construction and applications. Medical Imaging 2008: Image Processing, Reinhardt JM and Pluim JPW. Eds., Bellingham, WA, 2008, vol. 6914 of Proceedings of SPIE, 691409.

Zahr NM, Rohlfing T, Pfefferbaum A, Sullivan EV. Problem solving, working memory, and motor correlates of association and commissural fiber bundles in normal aging: A quantitative fiber tracking study. NeuroImage. 2009. 44(3): 1050-62.

Zahr NM, Sullivan EV. Translational studies of alcoholism: Bridging the gap. Alcohol Research and Health. 2008. 31(3): 215-30. Pfefferbaum, A, Zahr NM, Mayer D, Vinco S, Orduna J, Rohlfing T, Sullivan EV. Ventricular expansion in wild-type Wistar rats after alcohol exposure by vapor chamber. Alcohol Clinical and Experimental Research. 2008. 32(8): 1459-67.

Zahr NM, Mayer D, Vinco S, Orduna J, Luong R, Sullivan EV, Pfefferbaum A. In vivo evidence for alcohol-induced neurochemical changes in rat brain without protracted withdrawal, pronounced thiamine deficiency, or severe liver damage. Neuropsychopharmacology. 2009. 34(6): 1427-42.

Sullivan EV, Zahr, NM. Neuroinflammation as a neurotoxic mechanism in alcoholism: commentary on “Increased MCP-1 and microglia in various regions of human alcoholic brain.” Experimental Neurology. 2008. 213(1): 10-17.

Zahr NM, Mayer D, Pfefferbaum A, Sullivan EV. Low striatal glutamate levels underlie cognitive decline in the elderly: Evidence from in vivo molecular spectroscopy. Cerebral Cortex. 2008. 18(10): 2241-50.

Mayer D, Zahr NM, Sullivan EV, Pfefferbaum A. In vivo metabolite differences between the basal ganglia and cerebellum of the rat brain detected with proton MRS at 3T. Psychiatry Research: Neuroimaging. 2007. 154(2): 267-73.

Mayer D, Zahr NM, Sullivan EV, Pfefferbaum A. In vivo fiber tracking in the rat brain on a clinical 3T MRI system using a high strength insert gradient coil. NeuroImage. 2007. 35(3): 1077-85.

Zahr NM, Martin LP, Waszczak BL. Subthalamic nucleus lesions alter basal and dopamine agonist stimulated electrophysiological output from the rat basal ganglia. Synapse. 2004. 54(2): 119-28.

Waszczak BL, Martin LP, Finlay HE, Zahr N, Stellar JR. Effects of individual and concurrent stimulation of striatal D1 and D2 dopamine receptors on electrophysiological and behavioral output from the rat basal ganglia. Journal of Pharmacology and Experimental Therapeutics. 2002. 300(3): 850-61.

Waszczak BL, Martin LP, Boucher N, Zahr N, Sikes RW, Stellar JR. Electrophysiological and behavioral output of the rat basal ganglia after intrastriatal infusion of d-amphetamine: lack of support for the basal ganglia model. Brain Research. 2001. 920(1-2): 170-82. Book Chapters Zahr NM. Chapter 6: Structural and Microstructural Imaging of the Brain in Alcohol Use Disorders. Handbook of Clinical Neurology. Sullivan EV, Pfefferbaum A (eds). 2014.

Zahr NM, Manning-Bog A, Alt C, Sullivan EV, Pfefferbaum A. Immune Responses in HIV Infection, Alcoholism, and Aging: A Neuroimaging Perspective. Cui C, Grandison L, Noronha A (eds). Springer. 2012.

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Zahr NM, Lough ME, Jung YC, Sullivan EV. Measurement of thiamine levels in human tissue. Food and Nutritional Components in Focus, B Vitamins. Preedy VR (ed). Royal Society of Chemistry Publishing. 2012.

Zahr NM, Pfefferbaum A, Sullivan EV. Chapter 4: Changes in the macrostructure and microstructure of the aging brain. Principles and Practice of Geriatric Psychiatry, 3rd Edition. Abou-Saleh M, Katona C, Kumar A (eds). Wiley-Blackwell. 2010.

Abstracts Zahr NM, Fama R, Rohlfing T, Sullivan EV, Pfefferbaum A. Neural Correlates of Cognitive Deficits in HIV Infection. Society on NeuroImmune Pharmacology (2015). Zahr NM, Sullivan EV, Pfefferbaum A. In Vivo MR Imaging Evidence for Variable CNS Responses to Repeated Binge Ethanol Treatment. American College of Neuropsychopharmacology (2014). Zahr NM, Colrain I, Sullivan EV, Pfefferbaum A. Brain Recovery in Sober Alcoholics. Pan Arabian Psychiatric Conference (2014). Zahr NM, Saranthan MK, Carr RA, Collins AM, Rohlfing T, Mayer D, Sullivan EV, Colrain IM, Pfefferbaum A. Brain metabolite levels as predictors of abstinence or relapse in alcohol use disorders. Society for Neuroscience (2014).

Zahr NM, Sullivan EV, Pfefferbaum A. In vivo diffusion tensor imaging evidence for reversible white matter microstructural integrity disruption: effects of abstinence in rat and man. Research Society on Alcoholism (2014).

Zahr NM. Translational studies using in vivo neuroimaging: from rats to man. Gordon Research Conference (2014).

Zahr NM, Sullivan EV, Pfefferbaum A. Neuroimaging of HIV and Alcoholism: Perspectives from Blood Markers. International Society for NeuroVirology (2013)

Zahr NM, Sullivan EV, Pfefferbaum A. In vivo diffusion tensor imaging evidence for reversible white matter microstructural integrity disruption with binge but not chronic ethanol exposure. American College of Neuropsychopharmacology (2013)  

Zahr NM, Mayer D, Sullivan EV, Pfefferbaum A. Influence of hepatitis C status on brain metabolites: evidence for neuroinflammation in HIV infected patients. Society for Neuroscience (2013)

Zahr NM, Sullivan EV, Pfefferbaum A. Models of alcoholism and common concomitants of alcoholism: differentiating pathological mechanisms. Research Society on Alcoholism (2013)

Zahr NM. Effects of Chronic Alcohol Consumption on Neurochemicals and Brain Energy. 3rd International Conference on Applications of Neuroimaging to Alcoholism (2013)

Zahr NM, Sullivan EV, Pfefferbaum A. Translational neuroimaging studies: from rats to man American College of Neuropsychopharmacology (2012)

Zahr NM, Sullivan EV, Pfefferbaum A. A mechanism of ventricular enlargement in an alcohol binge model. American College of Neuropsychopharmacology (2012)

Zahr NM, Pfefferbaum A, Sullivan EV. The effects of body mass index on magnetic resonance spectroscopy brain metabolite measurements. Society for Neuroscience (2012)

Alt C, Manning-Bog A, Sullivan EV, Pfefferbaum A, Zahr NM. Evidence for neuroinflammation in the thiamine deficient rat. Society for Neuroscience (2012)

Zahr NM, Pfefferbaum A, Sullivan EV. Alcohol exposure and nutritional deficiency in rat models: translational neuroimaging studies. Society for Neuroscience (2012)

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Pfefferbaum A, Zahr NM, Sullivan EV. Translational neuroimaging studies: from rats to man. American College of Neuropsychopharmacology (2012)

Zahr NM, Mayer D, Gu M, Orduna J, Alt C, Manning-Bog A, Sullivan E, Pfefferbaum A. CNS immune response in rats with liver damage. Research Society on Alcoholism (2012)

Zahr NM, Mayer D, Gu M, Rohlfing T, Sullivan EV, Pfefferbaum A. Neuroradiological signatures of thiamine deficiency and glucose loading in the rat revealed with MRI and MRS at 3T. Society for Neuroscience (2011)

Zahr NM, Mayer D, Hsu O, Vinco S, Orduna J, Bell RL, Sullivan EV, Pfefferbaum A. A comparison of in vivo neurochemical sequelae of binge alcohol exposure in wild type Wistar, alcohol preferring, and alcohol nonpreferring rats. Research Society on Alcoholism (2011)

Pfefferbaum A, Sullivan EV, Zahr NM. Alcohol exposure and nutritional deficiency in rat models: translational neuroimaging studies. Alcoholism and Stress Conference (2011)

Zahr NM, Chen C-H, Mayer D, Mochly-Rosen D, Sullivan EV, Pfefferbaum A. The effects of an aldehyde dehydrogenase activator on blood ethanol levels in mice and brain ethanol kinetics in rats. Society for Neuroscience (2010)

Sullivan EV, Zahr NM, Rohlfing T, Pfefferbaum A. Cognitive demands elicit tremor during quiet standing in alcoholics: Relation to tissue integrity of brain systems contributing to sensorimotor integration. Society for Neuroscience (2010) Zahr NM, Mayer D, Gu M, Sullivan EV, Pfefferbaum A. In Vivo Translational Study of Brain Glutamate in Aging and Alcoholism. American College of Neuropsychopharmacology (2010) Pfefferbaum A, Sullivan EV, Zahr NM. Neuroadaptation to Alcohol Exposure in Humans and Animal Models. Platform presentation at the International Behavioral Neuroscience Society meeting (2010)

Zahr NM, Luong R, Sullivan EV, Pfefferbaum A. Binge Ethanol Treatment Is Insufficient to Elevate Cytokine Levels Measured in Rat Blood, Liver, and Brain. Research Society on Alcoholism (2010)

Zahr NM, Gu M, Mayer D, Speilman DM, Sullivan EV, Pfefferbaum A. Glutamate and Glutamine Changes Induced by Ethanol Treatment in the Rat Brain Detectable with CT-PRESS at 3T. International Society of Magnetic Resonance in Medicine (2010)

Gu M, Zahr NM, Speilman DM, Sullivan EV, Pfefferbaum A. Mayer D. Quantification of Glutamate and Glutamine using CT-PRESS at 3T. International Society of Magnetic Resonance in Medicine (2010)

Zahr NM, Chanraud S, Mayer D, Sullivan EV, Pfefferbaum A. Neurochemical profiles of the human basal ganglia, cerebellum, and pons as influenced by age. Society for Neuroscience (2009)

Zahr NM, Mayer D, Hsu O, Vinco S, Orduna J, Sullivan EV, Pfefferbaum A. In Vivo Neurochemical Evidence for Alcohol Binge Induced Neural Compromise and Recovery in Alcohol-Preferring Rats. Research Society on Alcoholism (2009)

Zahr NM, Mayer D, Rohlfing T, Hasak M, Hsu O, Vinco S, Orduna J, Sullivan EV, Pfefferbaum A. Binge Ethanol Induced Structural and Neurochemical Changes in the Rat Brain Detectable at 3T. International Society of Magnetic Resonance in Medicine (2009)

Zahr NM, Crawford E, Hsu O, Vinco, S, Mayer D, Rohlfing T, Sullivan EV, Pfefferbaum A. Kainic acid seizures produce ventral hippocampal damage detectable with MRI and dorsal hippocampal damage followed by recovery detectable with serial MRS. Society for Neuroscience (2008)

Zahr NM, Mayer D, Vinco S, Orduna J, Sullivan EV, Pfefferbaum A. Long-term alcohol exposure by vapor chamber alters MRS detectable metabolites in rat striatum. Research Society on Alcoholism. Symposium platform presentation (2008)

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Zahr NM, Rohfling T, Pfefferbaum A, Sullivan EV. Quantitative fiber tracking in the normal aging brain: neuropsychological correlates. International Society of Magnetic Resonance in Medicine (2008)

Zahr NM, Mayer D, Sullivan EV, Pfefferbaum A. Basal Ganglia, cerebellum and pons detected in vivo with MR Spectroscopy: Aging and behavioral correlates. Society for Neuroscience (2007)

Zahr NM, Mayer D, Sullivan EV, Pfefferbaum A. Differential effects of age on tissue water-referenced proton metabolites in basal ganglia, cerebellum and pons using an MRS sequence optimized for glutamate detection. International Society of Magnetic Resonance in Medicine (2007)

Mayer D, Zahr NM, Sullivan EV, Pfefferbaum A. Differences in rat cerebellar and striatal metabolite ratios detected in vivo with optimized CT-PRESS. International Society of Magnetic Resonance in Medicine (2007)

Zahr NM, Mayer D, Sullivan EV, Pfefferbaum A. Differences in rat cerebellar and striatal metabolite ratios detected in vivo with optimized CT-PRESS. Society for Neuroscience (2006)

Mayer D, Adalsteinsson E, Rutt B, Zahr NM, Sullivan EV, Pfefferbaum A. In vivo diffusion tensor imaging of rat brain acquired with a 3T clinical MRI system and a high strength insert gradient coil. International Society of Magnetic Resonance in Medicine (2006)

Zahr NM, Martin LP, Collins HA, Tran TH, Waszczak BL. Subthalamic nucleus lesions alter basal and agonist-stimulated electrophysiological output from the rat basal ganglia. ASBMB/ASPET (2000)

Zahr NM, Martin LP, Collins HA, Tran TH, Freedman JE, and Waszczak BL. Subthalamic nucleus lesions alter basal and agonist-stimulated electrophysiological output from the rat basal ganglia. Society for Neuroscience (1999) Outreach 2011 The Sequoia Center, Redwood City 2012 The Sequoia Center, Redwood City 2013 Mills Hospital Chemical Dependency Center Alumni 2014 Mills Hospital Chemical Dependency Center Alumni Awards 1999 Travel Award Gordon Research Conference, Oxford, UK 2000 Poster Presentation Award New England Pharmacologists, Providence, RI 2001 Neumeyer Research Scholarship Award Northeastern University, Boston, MA 2007 Educational Stipend Award ISMRM, Berlin, GE 2007 NIH Loan Repayment Program Stanford University, Stanford, CA 2008 SRI Postdoctoral Fellowship Award SRI International, Menlo Park, CA 2008 RSA Junior Investigator Meeting Award Research Society on Alcoholism, Washington, DC 2008 RSA Gordis Research Recognition Award Research Society on Alcoholism, Washington, DC 2008 Women in Neuroscience Postdoc. Award Society for Neuroscience, Washington, DC 2008 SRI Spot Award / Outstanding Employee SRI International, Menlo Park, CA 2009 NIH Loan Repayment Program - Renewal Stanford University, Stanford, CA 2009 Educational Stipend Award ISMRM, Honolulu, HA 2010 ACNP Invited Panel Speaker ACNP, North Hollywood, FL 2012 ACNP Invited Panel Speaker ACNP, North Hollywood, FL 2013 ICANA Invited Speaker ICANA, Yale, CT 2013 McLean Imaging Center Invited Speaker Harvard Medical School, Belmont, MA 2013 ACNP Travel Award ACNP, North Hollywood, FL 2013 ACNP Poster Award ACNP, North Hollywood, FL 2014 Invited Speaker Gordon Research Conference, Galvasten, TX

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References Edith V. Sullivan, Ph.D. Adolf Pfefferbaum, M.D. Psychiatry and Behavioral Sciences Neuroscience Department Stanford University SRI International 401 Quarry Rd. Stanford, CA 94305 333 Ravenswood Ave. Menlo Park, CA 94025 (650) 859-2880 (650) 859-2927 edie@stanford.edu dolf@synapse.sri.com Mark Moss, Ph.D. Deborah Vaughn, Ph.D. Anatomy and Neurobiology Anatomy and Neurobiology Boston University School of Medicine Boston University School of Medicine 715 Albany St Boston, MA 02115 t 715 Albany St Boston, MA 02115 (617) 638-4200 (617) 638-5311 markmoss@bu.edu dvaughan@bu.edu