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CURRICULUMVITAE

MichaelGrantAgadjanyan,Ph.D.,D.Sc.PersonalData:CurrentOffice TheInstituteforMolecularMedicineAddress: 16371GothardStreet,H,HuntingtonBeach, CA92647-3652 Tel:(714)596-7821 FAX:(714)596-3791 Education:1979 Ph.D.,ImmunologyandImmunochemistry GamaleyaInstituteofEpidemiologyandMicrobiology, Moscow,Russia1989 D.Sc.(DoctorofScienceistheHighestDegreeinRussiaandseveralEU

Countries),ImmunologyandVirology,InstituteofViralPreparation,Moscow,RussiaProfessionalExperienceandAppointments:1975-1978 GraduateStudenttheGamaleyaInstitute,Moscow,USSR/Russia(Supervisor AaronGurvich,Ph.D.,D.Sc.)1979-1983 Scientist, Senior Scientist Immunology and Immunochemistry Laboratory the

GamaleyaInstituteUSSRAcademyofMedicine,Moscow,USSR/Russia 1983-1989 AssistantProfessor/AssociateProfessor,ImmunochemistryLaboratory,theInstitute

forViralPreparationUSSRAcademyofMedicine,Moscow,Russia1989-1992 ProfessorInstituteforViralPreparation/Mechnikov’sInstituteforVaccineandSera,

USSRAcademyofMedicine,Moscow1992-1993 VisitingProfessor(FacultyPosition),WistarInstitute,Philadelphia,PA, USA190141993-2000 Visiting Professor (Faculty Position), Department of Pathology Laboratory of

Medicine,UniversityofPennsylvania,Philadelphia,PA,USA190142000-2003 Professor, Head of Laboratory forMolecular Immunology, Institute forMolecular

Medicine,HuntingtonBeach,CA,USA926472003-present Vice-President,HeadofDepartmentofMolecular Immunology,Professor, Institute

forMolecularMedicine,HuntingtonBeach,CA,USA92647

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2005-present Adjunct Research Professor (Faculty Position), Institute for Memory ImpairmentsandNeurologicalDisorders,UniversityofCalifornia,Irvine,CA92697

PostgraduateTraining:1979-1983 TheGamaleyaInstituteofEpidemiologyandMicrobiology,Laboratoryof

ProfessorAronGurvich,Departmentof Immunology,LaboratoryofBiosynthesisofAntibodies

Awards,Honors,andMembershipinProfessionalSocieties:1970 Armenian’sResearchFellowshipAward,USSR1971 TravelAward,UniversityofYerevan,Armenia1972 YoungInvestigatorAwardUniversityofMoscow,USSR1975 OutstandingJuniorMemberAward,USSRAcademyofMedicine,Moscow1978 Institute of Gamaleya, Junior Investigator Award, USSR Academy of Medicine,

Moscow1980 MemberofProgramCommitteeforRussianImmunologyMeetingSuzdal,Russia.1981 USSRAcademyofMedicineResearchFundAward,Moscow1980-Present MemberofUSSR/RussianBiochemicalSociety1982-Present MemberofUSSR/RussianImmunologicalSociety1983-1992 RevieweroftheJournalVoprosiVirusologii,MoscowandPrague1985 MoscowInstituteforViralPreparationFoundationFirst Award1986 Member of Program Committee for Russian Immunology Society Meeting Tbilisi,

Georgia.1988 ResearchCouncilAcademyofMedicine,USSR1988 MoscowInstituteforViralPreparationFoundationFirstAward1989-1994 RevieweroftheJournalImmunology,Moscow,Russia1990-1992 MemberofCommitteeofExpertsforRussianAcademyofMedicine Infectiondiseases(includeAIDS)Foundation1989-1992 RussianAcademyofMedicineImmunologyFoundationAward1989-1992 Member of Doctoral Committee at the Gamaleya Institute of Epidemiology,

MicrobiologyandImmunology.1989-1992 RussianAcademyofSciencesBiotechnologyFoundationAward1989-1992 MemberofScientificAdvisoryBoardofNearmedicInc.,London/Moscow.1990-1992 MemberofDoctoralCommitteeatGabrichevskogo Instituteof EpidemiologyandMicrobiology1992-Present ReviewerforthejournalsDNAandCellBiology, Immunology, andJournalofClinicalInvestigationUSA.1994-1998 MemberofInternationalRetrovirusAssociation:HTLVandRelatedViruses1994-Present MemberofAmericanAssociationofImmunology1998-Present MemberofRussianAcademyofNaturalSciences1998-Present MultipleR21 andR01NIHAwards; CRDFAward; SusanKomen foundationAward;

Alzheimer’sAssociationAwards1998 KeynoteSpeakeratAEGurvich’sSeminar,InstituteofEpidemiologyand

Microbiology,RussianAcademyofMedicine,Moscow

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2000 HonorableDoctorofArmenianAcademyofScience2000-Present GrantReviewerNIH/NIAID,NIA,NINDS2007-Present AmericanSocietyforNeuroscienceU.S.Patents1.NucleicacidsencodingmutanthumanCD80andcompositionscomprisingthesamehumanCD80UnitedStatesPatent7446189(licensedtoWyeth/Pfizer,USA)2.PreventiveCancerVaccineBasedonBrotherofRegulatorofImprintedSitesMolecule(BORIS)PCT/WO2005/021029A2(worldwidepatentslicensedtoUniVax,USA)3.Proteinsforuseindiagnosingandtreatinginfectionanddisease,PCT/US2007/02194(licensedtoViralGeneticsInc,USA)4.EpitopeVaccineforPreventionandReversionofADPathology,PCT/US2008/010186(licensedRussianpatenttoNearmedicplus)5. Composition and methods related to diseases associated with deposits of amyloid, tau, and/or a-synuclein(US61,691,607;US61,792,770;USPCT13,55874.LicensedtoNeuroimmmune,LLC)6.Anti-tauantbiodiesandcompositionforandmethodsofmakingandusingintreatment,diagnosisandmonitoring of tauopathies (US 61,759,216; US 61,763,358; US Patent 13/839,135. Licensed to AGPTherapeutics,LLC)PastandPresentTrainees:(Morethan15undergraduatestudentsfromMoscowStateUniversity1988-1992)TatevicMegrabian Ph.D,5/80-8/85.InductionanddetectionofTandB-cellsimmuneresponses invivoandinvitroagainstviralantigensIrinaSmirnova MD,11/84-7/91. Inductionanddetectionofhumoral immuneresponses invitro

and in vivo (in adoptive transfer system) against T-independent bacterial antigenstypes1and2

NadezdaLogunova Ph.D,1/88-5/90.Generationandselectionofmonoclonalantibodiesagainstmousecellularantigens

AlexanderMaklakov MD, 7/87-11/91. Detection by ELISA and FACS anti-idiotypic antibodies againstantibodiestoinfluenzavirusPR8/34

MichaelChattergon UndergraduateStudent8/93-10/95.Generationofmonoclonalantibodies specifictonovel80kDputativecellularfusogenicreceptorforHTLV-I/II, cellularELISA,immunoprecipitation,WesternBlottingAraChalian MD, 8/93-11/94. Analysis of cDNA lambda ZAP-blu library, isolation and purificationofDNA,transfectionofeukaryoticcellsDanMcCallus Ph.D.3/94-5/95.DetectionofHIVandSIVproteinsintransfectedeukaryoticcellsby

immunoprecipitationandFACSassayArthurCho UndergraduateStudent8/94-2/85.Inductionanddetectionofhumoral immune

responsesagainstHIV-2envelop,andtatandrevproteinsofHIV-I byELISAaftercDNAinoculationNeilTrivedi UndergraduateStudent9/95-5/97.Generationofimmuneresponsesto HIV-2env.T-cellproliferation,immunoprecipitation,WesternBlottingMosiBennett UndergraduateStudent9/94-6/96.Detectionofneutralizingantibodies

againstHTLVnovelcellularreceptor.SyncytiaformationandvirustitrationinvitroWiltonLevine UndergraduateStudent9/95-9/96.Generationofimmuneresponsesto

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HIV-2env.ImmunizationinvivobycDNA,ELISA,WesternBlotting, cellfreeinfectionMichaelAppel UndergraduateStudent9/96-9/98.Generationofimmuneresponsesto SIVgag/pol.PurificationofcDNAandimmunizationinvivobytheseKhadyLoo UndergraduateStudent9/98-6/99.GenerationofimmuneresponsestoSIVgag/pol.

PurificationofcDNAandimmunizationinvivobythesecDNApreparations,ELISPOTTzveteDentchev 7/97-5/00. Mechanism of T-cell activation and role of CD80/86molecules in this

processGregoryArutunyan 12/99-3/00.Mechanismof T-cell activation and role of CD80/86molecules in this

processMichaelChattergoon 9/99-5/00. Mechanism of T-cell activation and role of CD80/86 molecules in this

processAnahitGhochikyan Ph.D. 6/00-Present.Generation of potent cellular immune responses against viral,

tumor,peptide,andbacterialantigens.ClinicaltrialswithmtDNAandPBMC’s.VitaliVasilevko M.S.9/00-9/03Generationofpotentcellularimmuneresponsesagainstviral,tumor,

andbacterialantigensandClinicaltrialswithNTfactorandEchinaceaNinaMovsesyan Ph.D.1/02-4/06.GenerationofvaccineagainstAlzheimer’sdisease.Preparationof

DNA constructs, immunizationofmice, detectionof cellular andhumoral immuneresponses

DavitBabikyan M.S.1/02-5/04.GenerationofvaccineagainstAlzheimer’sdisease. PreparationofDNA constructs, immunizationofmice, detectionof cellular andhumoral immuneresponses

NadjaSadzikava M.D. 11/01-9/03. Animal studies. Detection of NK cells in PBMCs, generation ofplasmids,immunizationofmice,etc.

MikayelMkrtichyan M.S.02/04-10/09.Thegenerationanddetectionofanti-BORISimmuneresponsesin4T1mousemodelofbreastcancer

GregoryMamikon Ph.D. 05/03-05/06. TNP clinical and pre-clinical studies. The purification of anti-amyloidantibodiesanddetectiontheirfunctions

HaykDavtyan Ph.D. 09/06-Present. Generation of vaccines and detection systems for CDCPathogensA,B,andC

DavitHovhannes Bachelor student. 02/09-05/09. Analyzing of therapeutic effect of long-termexpressionofscFvanti-Abetaantibodyinmice

JivanKhlghat Masterstudent.02/09-01/10.ThegenerationofDNAbasedepitopevaccineagainstbreastcancer

DmitryBolotin Master student. 02/10-06/10. Development of BORIS based vaccine delivered bydendritic cells or plasmid encoding this cancer-testis antigen against metastaticmousemammary

MikhailShugay Master student. 02/10-Present.DevelopmentofBORISbasedvaccinedeliveredbydendriticcellsagainstmetastaticmousemammary

ArpineDavtyan MS. 07/10-Present. Development of VRP-based anti-tumor vaccine in a mousemodelofbreastcancer.TestingTLR4agonistin4T1mousemodelofbreastcancer.

ArmineHovakimyan MS. 07/10-Present. The generation of protein and DNA based epitope vaccinesagainst AD. Detection of humoral and cellular immune responses in mice, rats,rabbitsmonkeys.

KarenZagorski,MS 05/12-Present.ThegenerationofmultipleDNAandrecombinantproteinsbasedonuniversalMultiTEPplatformandtestingitinmice,rabbitsandmonkeys.

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K.Kazarian,Ph.D. 08/14-Present. Thegenerationofdoubletransgenicmice(Aβ/tau)andanalysesofArmanezumabindifferentTau/Tgmice

MaxAntonenko,MS 09/15-Present. Testing various new MultiTEP-based vaccines fused with post-translational B cell antigenic epitopes (pyrogultamated Ab, phosphorylated Tau,AcetylatedTau,etc)

TeachingExperience:1988-1991-Immunology/VirologyCourse.Deliveredlecturesonhumoralandcellularimmuneresponsesagainst human pathogens. Pirogov's Institute of the Russian Academy of Medicine and Moscow StateUniversity35hrslectureperyearforaperiodof3years.1993-Present-SupervisionofundergraduatestudentsandgraduatestudentsatPathologyDepartmentattheUniversityofPennsylvania,andatIMM.1980-PresentThe lectureratdifferentuniversities and research institutionsaswell as international andnationalconferences.LecturesByInvitation:1985-1990 Moscow,Novosibirsk,Kiev,YerevanandothercitiesofformerUSSR.LectureTopics: (1)Mechanismsoftheantigendependentnon-specificimmuneresponse; (2)TandB-cellsinteractionandgenerationoftheantibodiesandantigendependent

non-specificimmunoglobulinsinvivoandinvitro; (3)ActivationoftheB-lymphocytes,roleT-cellsfactorsforspecificandnon-specific

immuneresponsesJune1986: UniversityofSeged,Hungary Anti-idiotypicregulationoftheimmuneresponseagainstinfluenzavirusSeptember1988: CRCLondon,UK.

SpecificapproachesforthegenerationmonoclonalantibodiesagainsttheconstantregionofEnvglycoproteinofHIV-1

Oct1988: University of Seged and Institute of Biochemistry in Budapest, Hungary. Induction

antibodiesagainstinfluenzaandadenovirustype6invitroApril1989: TheWistarInstitute,Philadelphia,USA

Antigenpresentingcells infectedbyHIV-IandtheirpotentialkillingofCD4positivecells

Nov1990: CRCandHolmsMedicusLondon,UK PossiblemechanismsofdepletionaCD4positiveT-cellsinaHIV-1infectedpatientMarch1991: TheUniversityofPennsylvania,Philadelphia,USA.

Generationmonoclonalantibodiesagainstrecombinantgp120HIV-IIIB;UsingFACSfordetectionofthepreparationinhibitingtheinteractionbetween

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HIVandCD4receptorJune1994: InstituteofViralPreparation,RussianAcademyofMedicine,Moscow

A novel 80kD antigen the HTLV-I/II putative fusogenic cellular receptor andgenerationofmonoclonalantibodiesagainstthisantigen.

Dec1995: Pro/NeuronInc.,WashingtonDC,USA Nucleicacidvaccineagainsthumanretroviruses.March1996: InstituteofTuberculosisRussianMinistryofHealth,Moscow,Russia. NucleicacidinoculationnovelmethodforvaccinationagainstHIV-I/IIApril1996: PublicHealthResearchInstitute,NewYork,USA Nucleicacidvaccinationagainstretroviruses.May1996: NavalMedicalResearchInstitute,Rockville,MD,USA NovelGeneticApproachesforVaccinesFebruary1997: ThomasJeffersonUniversity,CancerCenter,Philadelphia,USA DNA-basedHIVvaccine.Nov1997: TumorBiologySection,HeadandNeckSurgeryBranch,NIDCD/NIH,Bethesda,MD,

USA NovelGeneticMethodologyforGenerationofanti-Viralandanti-TumorVaccines.January1998: InstituteofBiomedicalInvestigations,UNAM,MexicoCity,Mexico DNAimmunizationfrommicetomenJune2002: ArmenianAcademyofSciences,Yerevan,Armenia ThefutureofDNAvaccinesNov2000: WHOlaboratoryattheInstituteofTuberculosis,Moscow,Russia ThegenerationofTBvaccineusingB7costimulatorymoleculesasmolecularadjuvant

Dec2003: TheInstituteforBrainAgingandDementia,UCI,Irvine,USA TheimmunotherapyofAlzheimer’sdisease:DNA,epitope,andmimotope vaccineapproachesApril2005: UniversityofCalifornia,Irvine,USA EpitopevaccineinwildtypeandthreedifferenttypesofAPP/Tgmice: immunologicalstudiesandAβpathologyMay2006: HarvardMedicalSchool,HarvardUniversity,Boston,MS,USA PrototypeAlzheimer’sDiseaseVaccineMay2006: Viralgenetics,Inc.,HarvardUniversity,Boston,MS,USA Detectionoftheactivecomponentsofcalfthymusnuclearproteins(TNP)

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Oct2006: GerontologyResearchCenterattheNIA,NIH,MA,USA PrototypeEpitopeVaccinesbasedonPeptidesandNucleicAcids.Nov2007: IchorInc.,San-Diego,USA DNAvaccinesforAD,problemsandsolutionsApril2008: Pharmexa,Inc.,SanDiego,USA PrototypeADVaccineSept2008: UniversityofPittsburgh,VaccineresCenterPA,USA VaccineResearchCenter,StrategiesinADVaccineDevelopment:Prophylactic vsTherapeuticVaccineOctober2008: UniversityofNebraskaMedicalSchool,USA SecondGenerationDNAbasedADVaccineJanuary2009: LundbeckA/G,NewJersey,USA Protein,peptide,andDNA-basedEpitopeVaccinesforAlzheimer'sDiseaseApril2009: IchorMedicalSystemsandH.LundbeckA/S,San-Diego,USA StrategiesinADvaccinedevelopment:prophylacticvstherapeuticVaccineAugust2009: RussianAcademyofMedicine,Moscow,Russia BORISasaNovelTumorAntigenfortreatmentofBrCAJanuary2009: ViralgeneticsInc.,Azusa,CA,USA SecondGenerationDNAADepitopeVaccineFebruary2010: GMBBio,Inc.,San-Francisco,USA DeliveryofvaccinesbybiodegradablenanoparticlesAug/Sep2010: Rosnanotechnology,Inc.,Niarmedic,Inc.,Immafarma,Inc.Moscow, St.Petersburg,Russia Cycleoflecturesonthedevelopmentofnano-vaccinesforADandBrCASept2010: UniversityofArkansasCancerCenter,Arkansas,USA Cancer-testisBORISbaseddendriticcellvaccineforBrCAMarch2011: 10th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD), 9-13March

2011,Barcelona,Spain(Invitedspeaker):Alzheimer’sDiseaseEpitopeVaccines

March2011: LundbeckA/G,Copenhagen,Denmark

EpitopeVaccinesReducesAD-likePathologyinAPP/TgMiceMarch2011: LundbeckA/G,Copenhagen,Denmark

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Alzheimer’sDiseaseEpitopeVaccinesbasedonDNA,peptidesorrecombinantProteins

October2012 Alzheimer’sDiseaseResearchCenter,UCLA,Los-Angeles,CA,USA

Alzheimer’s Disease Active Vaccination Strategy: Targeting Aβ and Tau pathology inasymptomaticpre-ADsubjects

Sep2015 ImmunotherapeuticstrategiestofightADandmetastaticBrCA MexicoCity,SenateoftheRepublicofMexicoNov2015 ActivevaccinationstrategiestopreventandreverseAlzheimer’sDisease(AD) KeynotepresentationonOMICSVaccinesandVaccinationsCongress,San-FranciscoDec2015 TargetingToll-LikeReceptor4(TLR4)withpharmaceuticalgradenon-toxicagonistas

atherapeuticstrategyformetastaticbreastcancerOralPresentationsatConferences(NotIncludingPosterPresentations)October1975: 10thMeetingofUSSRYoungImmunologists:Dynamicsoftheantibodyformationduring

cultivationimmunemousesplenocytesinvitroOctober1976: 11thMeetingofUSSRYoungImmunologists:Theinfluenceoftemperatureofincubation

onantibodyformationinthelymphaticcellculturesJuly1978: AnnualMeetingoftheUSSRBiochemistrySociety,Leningrad,Russia:Differentiationof

B-cellstoAFCwithoutdivisionDec1979: USSRAcademyofMedicine,Kiev:IncreasingoftheAFCandnIFCnumberinm miceimmunizedwithT-dependentandT-independentantigensAugust1980: AnnualMeetingofFederationofEuropeanBiochemistrySocieties (FEBS),Rome, Italy:

Antigen-inducedincreaseinthenumberofnonspecificimmunoglobulin-formingcellsinvitro

Sept1981: Annual Meeting of FEBS, Moscow, Russia: A sharp antigen-induced increase in the

numberofIFCinculturesApril1983: SecondinternationalConferenceonBoneMarrow,Novosibirsk,USSR: Theroleof antigen-bindingcellsintheformationofAFCandIFCinliving animalsandinvitroSept1984: AnnualMeetingoftheUSSRNationalAcademyofScience(SectionofBiology),Moscow:

IdiotypicregulationofimmuneresponsetoinfluenzavirusPR/8Sept1987: InternationalMeetingof Epidemiology and immunologyof InfluenzaVirus, Leningrad:

Inductionofimmuneresponsetoinfluenzavirusinsplenocytescultureofmice

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October1990: AnnualMeetingof European Federationof Immunological Societies (EFIS), Edinburgh,Scotland:Antigen-bindingB-lymphocytesinvolvedintheformationAFCandIFC

August1992: AnnualMeetingEFIS,Budapest,Hungary:Theroleofantigen-bindingBlymphocytesin

thespecificandnon-specificimmuneresponsesinvivoandinvitroSept1992: Vaccine 1992 Conf in Cold Spring Harbor Laboratory Meeting, USA: Genetic

immunization:anovelmethodforvaccinedevelopmentagainstHIVMarch1992: Keystone Symposium, Molecular immunology of virus infections: Identification of a

membraneantigenimportantforHTLVsyncytiaformationSeptember1993: Vaccines1994Conf,ColdSpringHarborLaboratoryMeeting,USA: Immune response

inrabbitsafterinoculationwithanHTLV-1envelopeDNAconstructMay1994: 6thInternationalMeetingofRetrovirologyAssociationHTLVandRelated Viruses, New-Jersey,USA:Anovel80kDantigentheHTLV-I/IIputative fusogenic cellularreceptorJune1994: AnnualMeeting of European Federation of Immunological Societies (EFIS), Barcelona,

Spain:Generationofmonoclonalantibodiesagainstanovel80kDantigentheHTLV-I/IIputativefusogeniccellularreceptor.

October1995: 7th International Meeting of Retoviruses Paris, France: Monoclonal antibodies against 80kDacellularantigenimportantHTLVinfection.May1996: CambridgeSymposiaTumorVaccines,TaosNM,USA:NovelGenetic Approaches forTumorVaccinesandImmunotherapySep1997: Vaccines1996,ColdSpringHarborLaboratoryMeeting,USA: HIV-2 expression vector

generate cross strain humoral and cellular anti-HIV-2 as well as anti-SIV immuneresponses.

April1998 6-th InternationalExpertForumon ImmunotherapyandGeneTherapyFlorence, Italy:

ExpressionofCD86andMHCclassIinthemuscletissueinduceanti-viralCTLsMay1999 NewConceptsinHIVVaccineDevelopmentsatNIH/AVRCWorkshop,Washington,USA:

Inhibitionofanti-HIV-1cellular immuneresponsesbyC-domainofCD80costimulatorymolecule

March1999: 2ndInternationalConferenceontheControlofInfectiousDiseases,Infectious ControlWorldOrganization,Minsk.MulticomponentDNAVaccinesand ImmuneResponseJuly2002 8thinternationalconferenceforAD,Stockholm,Sweden:

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(1) Adjuvant-dependent modulation of Th1/Th2 immune responses to immunizationwithβ-amyloidpeptide;(2)GenerationofimmuneresponsestoAβimmunization,usingDNAimmunizationtechnique

May2003 6thInternationalConferenceAD/PD,Seville,Spain: Conformation-specificpolyclonalanti-Aβ42antibodiesgeneratedinAPP/TgmiceMarch2005 7thInternationalConferenceAD/PD2005,Sorrento,Italy: PrototypeADVaccineUtilizingtheImmunodominantBcellepitopefromamyloid-βand

promiscuousTcellEpitopePADREMay2006: AAIBoston,USA: Induction of Potent Tissue Unrestricted Cancer Specific Immune Responses by

VaccinationwithaNovelOncoinitiatingTranscriptionFactor,BORISJuly2006: 3rdCTCF/BORISConference,SouthCarolina,USA. Immuneresponsestoanovelcancer-testisantigen,BORIS.August2006: Alzheimer’sDiseaseandRelatedDisorders,Madrid,Spain: DNA-basedAlzheimer’sdiseasevaccineOctober2007: 4thCTCF/BORISConference,Santander,Spain.Protectionagainstchallengewith breastcancergeneratedbyvaccinationwithtruncatedCT-antigen,BORISMarch2007: 8thInternationalConferenceAD/PD,Salzburg,Austria: TheSecondGenerationofDNA-BasedADVaccineAugust2007: BiomedicalAdvancedResearchandDevelopmentAuthority (BARDA),Washington,DC,

USA: GenerationofSinglePlatformDiagnosticTestforCategoryAandBPathogensSept2007: 2ndCongressforImmunomediateddiseases,Moscow,Russia

PrototypeAlzheimerdiseasevaccines:Problemsandsolutions June2008: DNAepitopevaccinepreventsADlikepathologyin3xTg-ADmiceandprotects themfromcognitivedecline.InternationalConferenceonPreventionofDementia. Washington,DC,USAJuly2008: InternationalConferenceonAlzheimer’sDisease(ICAD-2008),Chicago,IL: The novel strategy for generation of effective and safe Alzhaimer’s Disease vaccine

basedonconventionalinfluenzavirusvaccinemodifiedtoexpressAβ1-11.Dec2008: InternationalSocietyofVaccine,DNAVaccine2008,Las-Vegas,USA: DNAEpitopevaccineforAD.March2009: 9thInternationalConferenceAD/PD,Prague,CzechRepublic:

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Thirdgenerationofepitopevaccine(EV):AnewStrategyforAβimmunotherapyJuly2009: InternationalConferenceonAlzheimer’sDisease(ICAD-2009),Vienna,Austria:Induction

ofrapidandrobustanti-Aβantibodyproductionbyreactivationofpre-existingmemoryThcellsgeneratedfromconventionalvaccines

March2010: InternationalSocietyofVaccine,DNAVaccine2009,NewOrleans,LA,USA: 1)ImprovementofAlzheimer’sDisease(AD)DNAVaccineEfficacybyDNAPrime/Protein

BoostRegimeninMiceandRabbits; 2)DNAvaccineBasedonCancer-TestisAntigen,BORISand IL21molecularadjuvant in

extremelyeffectivefortreatmentofMetastaticDisease.April2010: AACR101stAnnualMeeting,Washington,DC,USA 1)ANovel Cancer-TestisAntigen, BORISBasedVaccineDeliveredbyDendritic Cells is

EffectiveagainstMetastaticDisease(NationalPressRelease) 2) Multivalent VRP-based anti-tumor immunotherapy is an effective therapeutic

strategyinaratmodelofbreastcancer.July2010: International Conference on Alzheimer’s Disease (ICAD-11, 2010), Alzheimer’s

Association,Honolulu,Hawaii,USA: Exploitingprime-boost regimenandvariousdeliverystrategies to improveAlzheimer's

DiseaseDNAvaccineefficacySept2010: WPRCancerInstitute,UNAM,USA: CancerImmunotherapyBasedonaNovelCancer-TestisAntigen,BORISFeb2011 MiNDUCI:EpitopeVaccinestargetinga-synandtauproteinsJuly2012: Alzheimer’sAssociationInternationalConference(AAIC)Alzheimer’sAssociation,VancouverCanada,2012,July14-19.TranslationalStudy:RefinementofDNAbasedAlzheimer’sDisease(AD)EpitopeVaccineinRabbits.Nov2012: MultiTEPplatformfortargetingamyloid,datainmice,rabbitsandmonkeys:Alzheimer's

DiseaseResearchForum(ADRF),UCLAJuly2013: ImmunogenecityofMultiTEPplatforminvariousspecies:targetingamyloid,tau,anda-syn,

aswellasdualortriplevaccines:Pharmsinthes,St.Petersburg;NearMedic,MoscowAugust2014:Aramanezumab,novelanti-0tauhumanizedMab NanolekInc.,LosAngelesJune2014:ActiveandPassivevaccinationforADandPD

NearmedicPlus,IncandImmapharma,LLC,MosocwRussia

June2015 TLR4agonistbasedimmunotherapyofcancer 4IAMCcongressplenarytalk,Yerevan,Armenia

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June2015 DNAVaccinesforAlzheimer’sDiseaseSatelliteSymposiumfor4IAMCcongress

Nov2015 NewstrategiesforADvaccinations,Keynotepresentation OMICS9thglobalVaccinesandVaccinationsDec2015 AnovelTLR4agonistfortreatingofmetastaticBrCAdisease OMICS9thglobalVaccinesandVaccinationsJune2016 AAIC2016,CanadaJan2017 JPMorganBio:TalkatEliLilly:MultiTEPasuniversalvaccineplatformfor

neurodegenerativedisorders.

July2017 AAIC2017,LondonJan2017JPMorganBio:TalkatEliLilly:MultiTEPasuniversalvaccineplatformforneurodegenerativedisorders.July2017AAIC2017London ClinicalStudiesJanuary-August2002: The effect of different preparations of Echinacea on human and murine

immunesystems.June-November2002 The effects of NT Factor (phosphoglycolipid extract) on mitochondrial

functionsandmutationofmtDNAinelderlypeople.February2003-2005 Effect of TNP on HIV virus load in plasma and PBMC of infected patient

(ClinicaltrialinChinawithViralGenetics,Inc)January2004-2008 EffectofTNPandHAARTonHIVvirus loadinplasmaandPBMCof infected

patient(ClinicaltrialinSouthAfricawithViralGenetics,Inc)June2009-Present Testing safety and toxicity of DNA epitope vaccine for Alzheimer’s disease

(INDforUSFDA).

Publicationsinpeer-reviewedjournals(PublishedabstractsarenotpresentedandplscheckPubmedforvariousspellingofAgadjanyanMGnames,suchasAgadjanyanM,AgadjanianM,AgadjanianMG,AgadzhanianMG,AgadzanyanM,Agajanian,MG,AgajanianM)

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1.Agadjanyan,M.G.andGurvich,A.E.Studyofantibodyformationduringcultivationimmunemousesplenocytesinvitro.ArmenianJ.ofBiology1976,29:3-10.

2.Agadjanyan,M.G.andGurvich,A.E.Dependenceofantibodyformationinthelymphaticcellculturesfromthetemperatureofincubation.Bull.Exp.Biol.Med.1977,12:700-703.

3.Agadjanyan,M.G.,Gurvich,A.E.,Grigoreva,O.Appearanceofcellscapableofbeingconvertedtoantibody-formingcellswithoutdivisionatlatestagesoftheimmuneprocess.ProceedingsoftheAcademyofScienceoftheUSSR.1978,242:449-452.

4.Sidirova,E.,Agadjanyan,M.G.,Korukova,A,Gurvich,A.E.Antigen-inducedincreaseinthenumberofnonspecificimmunoglobulin-formingcellsinvitro.Bull.Exp.Biol.Med.1980,8:64-66.

5.Agadjanyan,M.G.,Megrabyan,T.,Sidorova,E.IncreaseintheAFCandnIFCnumberinmiceimmunizedwithT-dependentandT-independentantigens.Bull.Exp.Biol.Med.1981,8:66-69.

6.Sidorova,E.,Agadjanyan,M.G.,Korukova,A.,Gurvich,A.E.Asharpantigen-inducedincreaseinthenumberofcellssecretingnon-specificimmunoglobulinsinvitro.Immunol.Letters1981,3:21-26.

7.Agadjanyan,M.G.andSidorova,E.Theroleofantigen-bindingreceptorsintheformationofspecificandnon-specificimmunoglobulin.In3Soviet-SwissMeeting,Ed.AcademyofScience,USSR.1983:1,144-148.

8.Agadjanyan,M.G.,Nesterenko,V.,Megrabian,T.Inhibitionofantigen-dependentnIFCbysyngeneicanti-SRBCimmunoglobulins.Bull.Exp.Biol.Med.1985:3,328-330.

9.Agadjanyan,M.G.,Nesterenko,V.,Megrabian,T.Inhibitionofcellsproducingantigen-dependentnon-specificimmunoglobulinsbyisologousanti-erythrocyteimmunoglobulins.Immunol.Letters.1985,9:307-311.

10.Agadjanyan,M.G.,Megrabian,T.,Sidorova,E.Theroleofantigen-bindingcellsintheformationofantibodyandantigendependentnonspecificimmunoglobulinproducers.Bull.Exp.Biol.Med.1985,9:327-330.

11.Megrabian,T.,Agadjanyan,M.G.,Zaritskaja,L.,Sidorova,E.Formationofantigen-dependentnIFCinmiceimmunizedwithtwoT-independent-antigens.Bull.Exp.Biol.Med.1985,10,451-454.

12.Agadjanyan,M.G.ThemechanismofB-cellactivation.In"Molecularandcellularregulationofinfectiousimmunity"Ed.AcademyofMedicalScience,USSR,Moscow,1985,18-37.

13.Agadjanyan,M.G.,Smirnova,I.N.,Sidorova,E.Thedependenceofthenon-specificimmunoglobulinproducerformationonthedosesofT-dependentandT-independentantigens.Bull.Exp.Biol.Med.1986,8:206-208.

14.Agadjanyan,M.G.,Smirnova,I.N.,Sidorova,E.TheroleofGo-andG1-splenocytesandantigen-blindinglymphocytesintheproductionofantigen-dependentnonspecificimmunoglobulins.Bull.Exp.Biol.Med.1986,11,589-592.

15.Agadjanyan,M.G.DifferentiationandactivationofB-lymphocytes.UspechiSovr.Biol.1987,104,55-70.

16.Agadjanyan,M.G.ActivationofB-cellsandmechanismsofT-B-lymphocytesinteraction.Immunology(USSR).1987,3,13-17.

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95. Movsesyan N, Mkrtichyan M, Petrushina I, Ross T, Cribbs DH, Agadjanyan MG, Ghochikyan A.Generationoffunctionalanti-amyloidantibodiesafterimmunizationwithDNAencodingmultiplecopiesofAb-peptideimmunogenfusedwithC3d.JournalofNeuroimmunology,2008,205,57-63.

96.Petrushina I.,GhochikyanA.,MkrtichyanM.,MamikonyanG.,MovsesyanN.,AjdariR.,VasilevkoV.,Karapetyan A., Lees A., Agadjanyan MG., Cribbs DH. Mannan-Aβ28 conjugate prevented Aβ-plaquedeposition,butincreasedmicrohemorrhagesinthebrainsofvaccinatedTg2576(APPsw)mice,JournalofNeuroinflammation,2008,5,42-49.

97.CribbsDHandAgadjanyanMG.ActiveandpassiveAβ-immunotherapy:preclinicalandclinicalstudiesandfuturedirections:partI/II.CNSNeurolDisordDrugTargets,2009,1:1-16.

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98. Agadjanyan M.G. and Cribbs D.H. Active and passive Aβ-immunotherapy: preclinical and clinicalstudiesandfuturedirections:partI/II.CNSNeurolDisordDrugTargets,2009,2:82-87.

99.DavtyanH,MkrtichyanM,MovsesyanN, Petrushina I,MamikonyanG, CribbsDH,AgadjanyanMG,GhochikyanA.2010.DNAprime-proteinboost increased the titer, avidity andpersistenceof anti-Abetaantibodiesinwild-typemice.GeneTher.17(2):261-71.

100. Movsesyan N, Davtyan H, Mkrtichyan M, Petrushina I, Tiraturyan T, Ross TM, Agadjanyan MG,GhochikyanA,CribbsDH.2010.Lowconcentrationsofanti-AbetaantibodiesgeneratedinTg2576micebyDNAepitopevaccine fusedwith3C3dmolecularadjuvantdonotaffectADpathology.HumGeneTher.,2010,21(11):1569-1576.

101.RobertR,LefrancMP,GhochikyanA,AgadjanyanMG,CribbsDH,VanNostrandWE,WarkKL,DolezalO. Restricted V gene usage and VH/VL pairing of mouse humoral response against the N-terminalimmunodominantepitopeoftheamyloidβpeptide.Mol.Immunol.,2010,48(1-3):59-72.

102.MkrtichyanM,GhochikyanA,DavtyanH,MovsesyanN,LoukinovD,LobanenkovV,CribbsDH,LaustAK,NelsonEL,AgadjanyanMG.Cancer-testisantigen,BORISbasedvaccinedeliveredbydendriticcellsisextremely effective against a very aggressive and highly metastatic mouse mammary carcinoma. CellImmunol.2011;270(2):188-97.

103. Davtyan, H., Ghochikyan, A., Cadagan, R., Zamarin, D., Petrushina, I., Movsesyan, N., Martinez-Sobrido,L.,Albrecht,RA.,García-Sastre,A.,Agadjanyan,MG.Theimmunologicalpotencyandtherapeuticpotential of a prototype dual vaccine against influenza and Alzheimer's disease. J. Translational Med.,2011,9:127

104. de Necochea-Campion R., Ghochikyan A., Josephs S.F., Zacharias S., Woods E., Karimi-Busheri F.,Alexandrescu D.T., Chen C.S., Agadjanyan M.G., Carrier E. Expression of the epigenetic factor BORIS(CTCFL)inthehumangenome.JTranslMed.2011,9:213.

105. Ghochikyan, A. and Agadjanyan, M.G. CAD-106, a beta-amyloid-based immunotherapeutic forAlzheimer'sdisease,ReviewinThomsonReutersCortellis2012,May9

106.Davtyan,H.,Ghochikyan,A.,Movsesyan,N., Ellefsen,B., Petrushina, I., CribbsDH, Hannaman,D.,Evans,CF,Agadjanyan,MG.DeliveryofaDNAvaccineforAlzheimer’sdiseasebyelectroporationorgenegungeneratespotentandsimilarimmuneresponses.NeurodegenerDis.2012,10:261-4.

107.GhochikyanA,DavtyanH,Petrushina I,HovakimyanA,MovsesyanN,DavtyanA,KiyatkinA,CribbsDH,andAgadjanyanMG.RefinementofaDNAbasedAlzheimer'sdiseaseepitopevaccineinrabbits.HumVaccinImmunother.2013May;9(5):1002-10.doi:10.4161/hv.23875.Epub2013Feb11.PMID:23399748

108. Davtyan, H., Ghochikyan, A., Petrushina,I., Hovakimyan, A., Davtyan, A., Poghosyan, A.,Marleau,A.M.,Movsesyan,N., Kiyatkin, A., Rasool, S., Larsen, S.A.,Madsen, P.J.,Wegener, K.M.,Ditlevsen,D.K.,Cribbs, D.H., Pedersen, L.O., Agadjanyan, M.G.. Immunogenicity, Efficacy, Safety, and Mechanism ofActionofEpitopeVaccine(LuAF20513)forAlzheimer’sDisease:PreludetoaClinicalTrial. J.Neurosci., JNeurosci.2013,33:4923-34.

109.CohenRM,Rezai-ZadehK,WeitzTM,RentsendorjA,GateD,SpivakI,BholatY,VasilevkoV,GlabeCG,BreunigJJ,RakicP,DavtyanH,AgadjanyanM.G.,KepeV,BarrioJR,BannykhS,SzekelyCA,PechnickRN,TownT.AtransgenicAlzheimerratwithplaques,taupathology,behavioralimpairment,oligomericaβ,andfrankneuronalloss.JNeurosci.2013,33:6245-56

110. Evans C.F., Davtyan H, Petrushina I., Hovakimyan A., Davtyan A., Hannaman D., Cribbs D.H.,Agadjanyan M.G., Ghochikyan A. // Epitope-based DNA vaccine for Alzheimer’s disease: translational

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study in macaques. Alzheimers Dement.2014 May;10 (3):284-95. Alzheimers Dement. 2014May;10(3):284-95.doi:10.1016/j.jalz.2013.04.505.Epub2013Jul31.PMID:23916838

111. Ghochikyan A, Davtyan A, Hovakimyan A,Davtyan H, Poghosyan A, Bagaev A, Ataullakhanov RI,Nelson EL,AgadjanyanMG. Primary 4T1 tumor resection provides critical "windowof opportunity" forimmunotherapy.ClinExpMetastasis.2014Feb;31(2):185-98.doi:10.1007/s10585-013-9619-0.Epub2013Oct6.PMID:24096737

112. Ghochikyan A., Petrushina I., Davtyan H., Hovakimyan A., Saing T., Davtyan A., Cribbs D.H.,AgadjanyanM.G.,ImmunogenicityofepitopevaccinestargetingdifferentBcellantigenicdeterminantsofhuman α-synuclein: Feasibility study. Neurosci Lett. 2014 Feb 7;560:86-91. doi:10.1016/j.neulet.2013.12.028.Epub2013Dec19.PMID:24361548

113.DavtyanH.,GhochikyanA.,HovakimyanA.,PetrushinaI.,YuJ.,FlyerD.,MadsenP.J.,PedersenL.O.,CribbsD.H.,AgadjanyanM.G., ImmunostimulantpatchescontainingEscherichiacoliLTenhanceimmuneresponses toDNA-and recombinantprotein-basedAlzheimer'sdiseasevaccines. JNeuroimmunol.2014Mar15;268(1-2):50-7.doi:10.1016/j.jneuroim.2014.01.002.Epub2014Jan15.PMID:24507620

114. Davtyan H., Bacon A., Petrushina I., Zagorski K., Cribbs D.H., Ghochikyan A., Agadjanyan M.G.,Immunogenicity of DNA- and recombinant protein-based Alzheimer Disease Epitope Vaccines. HumVaccine& Immunother. 2014 Feb 13;10(5):1-8. HumVaccin Immunother. 2014May;10(5):1248-55. doi:10.4161/hv.27882.Epub2014Feb13.PMID:24525778

115.DavtyanH,GhochikyanA,Petrushina I.,HovakimyanA.,DavtyanA.,CribbsD.H.,AgadjanyanM.G.,MultiTEP platform-based AD epitope vaccine activates broad repertoire of T helper cells in non-humanprimates.AlzheimersDement.2014May;10(3):271-83.doi:10.1016/j.jalz.2013.12.003.Epub2014Feb20.PMID:24560029

116. DavtyanH, HovakimyanA., Zagorski K., DavtyanA., Petrushina I., AgdashianD.,Murthy V., CribbsD.H.,AgadjanyanM.G.,GhochikyanA,BTXAgilePulseMTSystemisanEffectiveElectroporationDeviceforIntramuscular and Intradermal Delivery of DNA Vaccine. Curr. Gene Ther. 2014;14(3):190-9. PMID:24867066117.DavtyanH,GhochikyanA,HovakimyanA,DavtyanA,CadaganR,MarleauAM,AlbrechtRA,García-SastreA,AgadjanyanMG.Adualvaccineagainstinfluenza&Alzheimer'sdiseasefailedtoenhanceanti-β-amyloidantibodyresponsesinmicewithpre-existingvirusspecificmemory.J.Neuroimmunol.2014Dec15;277(1-2):77-84.doi:10.1016/j.jneuroim.2014.10.002.Epub2014Oct16.PMID:Selectitem25455094118. Ghochikyan A, Pichugin A, Bagaev A, Davtyan A, Hovakimyan A, Tukhvatulin A, Davtyan H,Shcheblyakov D, Logunov D, Chulkina M, Savilova A, Trofimov D, Nelson EL, Agadjanyan MG,AtaullakhanovRI.TargetingTLR-4withanovelpharmaceuticalgradeplantderivedagonist,Immunomax®,asatherapeuticstrategyformetastaticbreastcancer.JTransl.Med.2014Nov29;12(1):322.[Epubaheadofprint]PMID:25432242119.AgadjanyanMG,PetrovskyN,GhochikyanA.Afreshperspectivefromimmunologistsandvaccineresearchers:ActivevaccinationstrategiestopreventandreverseAlzheimer'sdisease.AlzheimersDement.2015Jul17[Epubaheadofprint]PMID:26192465120.DavtyanH,ZagorskiK,RajapakshaH,HovakimyanA,DavtyanA,PetrushinaI,KazarianK,CribbsDH,PetrovskyN,AgadjanyanMG,GhochikyanA.Alzheimer'sdiseaseAdvax(CpG)-adjuvantedMultiTEP-based

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dualandsinglevaccinesinducehigh-titerantibodiesagainstvariousformsoftauandAβpathologicalmolecules.SciRep.2016Jul1;6:28912,PMID:27363809

121.PetrushinaI.,Davtyan,H.Hovakimyan,A.Davtyan,A.Passos,G.F,,Cribbs,D.H.,Ghochikyan,A.,Agadjanyan,M.G.ComparisonofEfficacyofPreventiveandTherapeuticVaccinesTargetingtheNTerminusofb-AmyloidinanAnimalModelofAlzheimer’sDisease.MolTher.2017Jan4;25(1):153-164.doi:10.1016/j.ymthe.2016.10.002.Epub2017Jan4.PMID:28129111

122.Davtyan,H.,Chen,W.W.,Zagorsky,K.,Davis,J.,Petrushina,I.,Cribbs,D.H.,Agadjanyan,M.G.,Blurton-Jones,M.,Ghochikyan,A.MultiTEPplatform-basedDNAepitopevaccinetargetingN-terminusoftauinducesstrongimmuneresponsesandreducestaupathologyinTHY-Tau22mice.Vaccine,2017Apr11;35(16):2015-2024.doi:10.1016/j.vaccine.2017.03.020.Epub2017Mar18.PMID:28320590

123.DavtyanH,ZagorskiK,PetrushinaI,KazarianK,GoldbergNRS,PetrosyanJ,Blurton-JonesM,MasliahE,CribbsDH,AgadjanyanMG,GhochikyanA.MultiTEPplatform-basedDNAvaccinesforalpha-synucleinopathies:preclinicalevaluationofimmunogenicityandtherapeuticpotency.NeurobiolAging.2017Aug10.pii:S0197-4580(17)30261-0.doi:10.1016/j.neurobiolaging.2017.08.006.[Epubaheadofprint]PMID:28870518

124.AgadjanyanMG,ZagorskiK,PetrushinaI,DavtyanH,KazarianK,AntonenkoM,DavisJ,BonC,Blurton-JonesM,CribbsDH,GhochikyanA.HumanizedmonoclonalantibodyarmanezumabspecifictoN-terminusofpathologicaltau:characterizationandtherapeuticpotency.MolNeurodegener.2017May5;12(1):33.doi:10.1186/s13024-017-0172-1.PMID:28472993