CURRICULUM VITAE Adesuyi Adeyinka Leslie AJAYI , M.D. , Ph.D., FBPharmacolS LeslieAdeAjayi@ymail.com Swiftsword09@gmail.com 2607 Villa Del, Sugarland, TX 77498. . Telephone, 832-406-0772

Name : Adesuyi Adeyinka Leslie AjayiMarital status : Married with a daughter-Obafunso- Ph.D. Candidate , Columbia University, Nanophotonics and Mechanical Engineering Department. NY.Citizenship : American.

UNIVERSITY EDUCATION

1982- 1985. University of Glasgow, Scotland , United Kingdom.1973-1980. University of Ife, Ile-Ife, Nigeria. ( Now Obafemi Awolowo University ).

DEGREES AND PROSSSIONAL DIPLOMAS 1. 1989- Fellow, West African College of Physicians. (FWACP).2. 1985- Ph.D. ( Glasgow ). Clinical pharmacology.3. 1980- M.B., Ch.B ( Ife) MD equivalent. 4. 1980 - Educational Commission for Foreign Medical Graduates ( ECFMG) 5. 1977 - BSc, Health Sciences( 2 1Honors) Physiology (Ife) .Licensure Nigeria Medical Council – Full registration – 1981.General Medical Council of Great Britain –limited – 1991 -# 5075South Carolina Board of Medical Examiners – 1993, LL 25150.

OTHER ACADEMIC HONORS, AWARDS AND DISTINCTIONS.

2006 Fellow, British Pharmacological Society (FBPharmacolS) – Election to Fellowship based on distinction in pharmacology and contribution to the Society. 2005. International Order of Merit (IOM) –International Biographical Center Cambridge, England, UK [ Membership restricted to 500 in the World ]

For services to clinical pharmacology and the human society. 2003. Invited Symposium speaker “ Non genomic effects of estrogens”. –American Society of Pharmacology and Experimental Therapeutics-FASEB. San Diego, CA.2003. Biographee, Who-is-Who in Nigeria, Nigerian Biographical institute.2002. Distinguished Alumnus Award- Obafemi Awolowo University, Ile-Ife, Nigeria.

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1999. Biographee, Marquis Who-is-Who in the World. 16th Edition.1996. The Outstanding Young Person of Nigeria Award, for Academic accomplishments and leadership. ( Junior Chamber International ).1995. First Alumni Professor of Medicine Award & Feschrift- Ife University Medical Students Association.1994. Young Investigator Award for Excellence in Scientific research. Baltimore , Maryland.American Society for Clinical Investigation/American Federation For Clinical Research. 1992. Merck,Sharp & Dohme International Fellow in Clinical pharmacology. 1991. Wellcome Trust Clinical Research Fellowship.1982. Committee of Vice-Chancellors and Principals of UK universities Award (ORS).( For Overseas Students of outstanding academic merit and research potential)1983. Federal Government of Nigeria Postgraduate Scholarship 1982. University of Glasgow Postgraduate Scholar ( Faculty of Medicine).1979 First Prize cup/First position , Nigeria Intermedical Schools , Quiz competition.( Organized by Nigeria Medical Students Association – NIMSA) 1977. Foundation Dean Medalist- Undergraduate Best Student Prize, Faculty of Medicine ,University of Ife, Ile-Ife, Nigeria. 1977. Faculty Prize, Overall best student in the Faculty of Medicine.1975. “ University Scholar ”, University of Ife, Ile-Ife, Nigeria. ( Designation and Award to best students with First class grade performance ). 1976. Ondo State, Nigeria Post –Secondary Merit Award ( First set awarded).

POSITION AND AFFLIATIONS : ( Reverse chronological order) Professor of Pharmacology, Saba University School of Medicine, the Bottom. Saba Dutch Caribbean. 2013-14.

Professor of Pharmacology, St James School of Medicine, Anguilla , BWI, 2012-13.

Professor of Pharmaceutical Sciences, , Department of Pharmaceutical Sciences, Chicago State University, 9501 S King Drive, Chicago IL 60628. 2008 to 2012. Part of Founding Faculty Professor. Program now accredited .

Adjunct Professor of Medicine, Department of Medicine, Hypertension and Clinical Pharmacology Section. Baylor College of Medicine,1 Baylor Plaza, Fannin Street, TX 77060.- 2001- date.

Professor of Biomedical Sciences, Department of Health Studies, College of Health Sciences, Chicago State University, 9501 S King Drive,

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Chicago IL 60628. 2007-2008.

Professor of Pharmacology, Ross University School of Medicine, PO Box 266, RoseauCommon Wealth of Dominica.-2006

Professor of Pharmacology and Clinical Therapeutics, St Matthew’s University School of Medicine, PO Box 32330 SMB, Safehaven, Grand Cayman Islands, BWI. 2005Consulting Author in Pharmacology – USMLEWORLD . LLC- March – October 2005

Senior Scientist and Visiting Professor Center for Cardiovascular Diseases, Texas Southern University, 3100 Cleburne Avenue, Houston ( NIH supported). Head of the Hypertension Subsection. Supervision of interns and post-doctoral researchers.Texas, 77004. USA. – 1999- 2004

Professor and Chair of Medicine, Obafemi Awolowo University Medical SchoolIle-Ife, Osun state, Nigeria. -1992- 2000. Academic and clinical supervision, appointments and promotion of 15 Academic Faculty and more than 50 interns, residents and Fellows in Medicine.Chief Examiner for Medicine (internal ). Administration of support staff, and report to the Dean of the Medical School, University Senate and the Vice-Chancellor of the University, and the Board of the University Teaching Hospital and the Chief Medical Director. Liaison with Profession bodies for Medical and postgraduate accreditation and re-accreditation of programs and facilities. Review of professors. Defended cases at the University Appointments and Promotions Committee.

Vice-Dean , Faculty of Clinical Sciences (Medical School) Obafemi Awolowo University. 1994-95.Vice-Chairman of the Faculty Board of Examiners, and Faculty Review Panel. Chief coordinator of Examinations and Curriculum review. Represented and deputized for Dean at Meetings in the Committee of Deans of the University. Budgeting and Resource allocation for didactic and research purposes. Choosing University Examiners and external liaison. Presented list of graduating Medical Doctors based on results from Department of Candidates who have fulfilled graduation criteria. Supervised 10 clinical Chairmen of Departments of the Medical school.

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I Academic and Research positions

Professor of Medicine, Obafemi Awolowo University, Ile-Ife, Nigeria , 1992-2000.

Reader in Medicine, Obafemi Awolowo University, Ile-Ife, Nigeria 1989-92.Senior Lecturer, Department of Medicine, Obafemi Awolowo University,

1987-1989.Lecturer I University of Ife, Ile-Ife, 1985-1987.

Training undertaken Abroad and During Study leave,Sabbatical from University of Ife*

*1992-94. Merck Sharp & Dohme International Fellow in clinical pharmacology, Division of clinical pharmacology, Department of Medicine, Medical University of South Carolina,Charleston, SC ( * On Leave of absence from Obafemi Awolowo University). Investigating testosterone regulation of platelet thromboxane A2 receptors in healthy volunteers and in castrated and uncastrated patients with prostate. Radioligand binding technics, platelet aggregation, assay, molecular pharmacological and cellular methods were employed.

*1991-92. Wellcome Trust Clinical Research Fellow, Division of Therapeutics, Department of Medicine, University of Nottingham, Queen’s Medical Center, NG7 2UH, UK. Clinical Research into the effects of heparin and low molecular weight heparinoids , enoxaparin or dalteparin on platelet behavior in pregnancy. Spontaneous platelet aggregation in whole blood using ultra-flo 100 platelet counting technic.

1982-5 Medical Training Fellow in the Clinical Pharmacology Training Program of the University of Glasgow Medical training Fellow, University Department of Materia Medica , Stobhill General hospital , G21 3UW , Glasgow , UK. ( Moved to Dept of Medicine and Therapeutics, Gardiner Institute, Western Infirmary, G11 6NT Glasgow, UK.). Conception and conduct of randomized controlled , single or double blind , or double dummy studies, using cross-over, parallel group or Latin squares designs. Pharmacokinetic analysis of drug concentrations involving both model dependent and independent were undertaken. Population pharmacokinetics using NONMEM ( Non-Linear Mixed Effect Model) was used to describe population kinetic parameter values for investigational new drugs such as enalaprilat ( MK422) or lisinopril ( MK521). Pharmacokinetic-Pharmacodynamic concentration effect models were employed in order to

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predict drug effect from plasma drug concentrations by comparing, linear, log-linear or Sigmoid –E max models with or without an effect compartment. Statistical analyses of data were undertaken using parametric and non-parametric methods, including different types of analyses of variance, multiple and logistic regression analysis. Clinical Pharmacology Consultation to Physicians in the Greater Glasgow Health Board Area and within Stobhill Hospital.

The Phase 1 evaluation of Investigational New Drugs for the Pharmaceutical industry was also undertaken for Merck ( MK421, MK422, MK 521 – enalapril, enalaprilat and lisinopril ), Hoffman la -Roche ( Ro-3112 –cilazapril ), Sevier ( S-9490- perindopril) and Squibb (captopril). Low molecular weight heparin – Dalteparin and enoxaparin (Rhone-Poulenc –Rorer ) during the course of these training and practice.

II Clinical Practice and Clinical pharmacologist Roles :Consultant Physician Clinical Pharmacologist and Cardiologist 1989- 1999: Teaching medical students and residents in the Cardiovascular Medicine Unit. Ambulatory and hospital care of Cardiac patients.( 2 clinics a week) Routine echocardiography , cardiac autonomic function and Treadmill Exercise ECG reporting, Intra-operative monitoring of high risk patients and Intensive Care patients.Evaluation of new and old drugs in clinical trials and interaction with Pharmaceutical industry representatives. Monitoring of adverse drug reactions and interactions.Initiated the first hospital Adverse drug reaction form and arranged seminars for its utilization. Chairman of Hospital Drug Formulary Committee ( wrote new hospital drug formulary) and Essential Drug list. Member, Hospital Drug Revolving Fund Committee – Reported to Hospital Management Board and Government. Member Hospital and University Research and Ethics Committee of OAUTHC Hospitals.

Other roles performed as clinical pharmacologist / Physician in Nigeria

Phase 1drug evaluation – Studies on healthy volunteers, involving combination of Alpha-1 blockers, ACE-Inhibitors, or Calcium Channel blockers in Nigerians. Beta-blockade effects on intraocular Pressure (IOP) in Nigerians.

Phase –II/IIIB drug evaluation – Enalapril in hypertension and heart failure, and hypertensive –diabetics ( Merck Sharp & Dohme UK ) ,

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Lisinopril ( Astra –Zeneca UK) , Cilazapril in hypertension ( Hoffman –La Roche ) –UK and Germany. , -lacidipine in hypertensive blacks ( Glaxo –UK ) , Amlodipine in hypertensive blacks comparison to hydrochlorothiazide ( Pfizer Nigeria PLC ). Captopril-prazosin in hypertensive acute pulmonary edema ( Pfizer –Nigeria PLC ).

Phase IV -, safety , efficacy and adverse effects – ACE inhibitor induced cough and angioedema in blacks, ACE Inhibitor reduction in mortality in black Africans with congestive heart failure. [ See publications ]

1980-2, 1985-89: Rotating Intern, Registrar and Fellow in Internal Medicine & Cardiology, and Acute care

Residency Training and passed all examinations for Fellowship of the College of Physicians already begun in 1982. Public Enlightenment on Radio ( Osun State Radio) and TV ( NTA – IBADAN ) on Hypertension and Heart Failure, Diabetes Treatment and Control . – 1995/6.

Current Research ( i) The interaction of sex-hormones , hyperinsulinemia and paracrine autocoids in the progression of type-2 diabetic endotheliopathy in Zucker diabetic rats –.(ii) The influence of ethnicity and hemoglobin AS trait on platelet and microvascular reactivity and on the target organ complications of type-2 diabetic patients using doppler –laser flowmetry. (iii) Cross-talk among the heptahelical G-protein coupled receptors in health and disease. (iv) The role of angiotensin II receptor subtypes and nitric oxide synthase isoforms in the development of cardiac cachexia in experimental and clinical heart failure. (v) Determination of the chemistry of an African aphrodisiac penile erection enhancer, [ Burantashi ]with alpha-2 antagonist, endothelin –1 and nitric oxide actions. ( vi) Hyperglycemia – Protein Kinase C connections – the physiological and pathological role of androgen receptor in diabetic microvascular disease. (vii) The role of matrix metalloproteinases in valvular regurgitation and left ventricular remodeling in hypertensive heart disease.(viii) Combined Renin –Angiotensin-System Blockers Effects on the Cardiac remodeling in Hypertensive heart disease and Failure.

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Courses taught at Chicago State University

College of Health SciencesMedical Science (pathophysiology)Medical TerminologyAlternate Health care and holistic medicine (Complemetary Alternative

Medicine)Personal Wellness/Ethnic health disparities

Pharmaceutical SciencesHuman physiology, Basic pathologyPathophysology, Receptor pharmacology Biochemistry, Genetics and PharmacogeneticsDrug Actions Structure and Therapeutics (DAST) series Cardiovascular pathophysiology, Pharmacology

Courses taught/facilitated at Ross University Medical School.Medical pharmacology IMedical Pharmacology IIIntroduction to clinical Medicine.Problem Based Learning /Simulator use.

Courses Taught at St Matthew’s University School of Medicine, Grand Cayman Islands

Pharmacology – 4th Semester Medical Students Clinical Therapeutics/ introduction to Medicine – 5th semester

Courses Taught at the Obafemi Awolowo University, Ile-Ife, Nigeria.

1. CLI 401- Cardiovascular system – First year Clinical, part IV M.B,. Ch.B.2. CLI 602- Internal Medicine ( cardiovascular medicine/clinical pharmacology and clinical pharmacokinetics and prescribing) – Final year Clinical rotations for Medical students. 3. Coordinator – First year clinical posting and Clerkship in Internal Medicine. 4. CLI-501- Clinical Pharmacology for Final year Pharmacy students.5. Internal Medicine postings for Part V Dental Surgery Students ( BDS).MRH-304 Neuromuscular and cardiovascular diseases for physiotherapy ( Bachelor of Medical Rehabilitation ) Students

Courses Taught at Texas Southern UniversityPAS 537 – Pharmacology and Toxicology 1 ( Phase 1 and 2 Drug metabolism

and drug disposition, Lipid lowering drugs )

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Other Administrative Duties at Chicago State University

Member, University Faculty Senate, Chicago State University.Member, University Personnel Committee, Chicago State UniversityMember, Departmental Personnel Committee, Dept of Pharmaceutical

Sciences.Chicago State University Institutional Review Board -2010-2012.

Scientific Conference /Presentation organizationScientific Secretary, Organization Committee -Prof TAI Grillo Feschrift -

Obafemi Awolowo University , Ile -ife , Nigeria 1990. (oral and poster presentations )

Course Coordinator, Cardiology Update and Lectures - West African College of Physicians -1989-93.

Scientific Reviewer and Coordinator -Conference Abstract and Presentations - 24th Annual General Meeting and Scientific Conference Nigerian Cardiac Society . Ile ife, Nigeria -1994

Faculty Coordinator of Faculty Seminars and journal publications -Faculty of Health Sciences , Obafemi Awolowo University, Ile-Ife, Nigeria - 1988-91.

Graduate Supervision –Thesis/dissertationsM.Sc . Programs.1. Isi James , MSc. ( Physiotherapy ) “Cardiovascular responses to inversion of the head”2.Oyeyemi Younous. MSc. ( Physiotherapy ). “ The effect of aerobic training on the cardiovascular responses to head-down posture “.3. Pungong JI . MSc. ( Physiology ) “ Effects of exercise intensity on the cardiorespiratory responses of atheletes and non-atheletes in Nigeria ”.

Final Part II Fellowship Dissertation Supervised

Dr R.O. Babalola – Fellowship of West African College of Physicians Dissertation.“ The Effect of Hypertension on the microvascular complications of

Diabetes Mellitus “- 1992.Recipient of a Joslin Diabetes Center Travel Fellowship Award, Harvard Medical School Boston MA, - November 1991,

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Dr PO Akinwusi – Fellowship of the West African College of Physician Dissertation.

“ The spectrum of hypertensive heart disease in Nigerians : A correlative study of echocardiography , treadmill exercise performance and cardiovascular autonomic function ”. – 1993.

Dr RT Ikem. – Fellowship of the Medical College of Physic of Nigeria Dissertation.“ Renal function and proteinuria in Nigerians with Diabetic

nephropathy ”- 1998.

Dr SO Olateju. Fellowship of the Medical College of ophthalmologists of Nigeria.“ The ocular hypotensive effect of selective ( betaxolol) and non-

selective ( timolol) beta-adrenergic blockers in healthy Nigerians and glaucoma patients ” – 1998.

Dr GG Sofowora- FWACP dissertation. In preparation. ‘ The effect of concurrent α-1 or β-1 adrenergic blockade and ACE inhibition in the treatment congestive heart failure in Nigerians “ .- Recipient of a Merck, Sharp and Dohme international Fellowship in clinical pharmacology - 1997.

Dr AQ Adigun. –Fellowship of the West African College of Physicians ( FWACP).“ Cardiac autonomic function in Nigerians with chronic congestive heart failure “.- 1998.Recipient of a Merck, Sharp and Dohme International Fellowship

in clinical pharmacology – 2000.

Pharm.D Summer Research Interns

James Cory Pharm.D -2002. Published work. 3rd Place in Research Presentation of work at National Association of Minority Pharmacy Students Conference.

Lucy Mutembei Pharm .D- 2003. Published work.1st and 3rd place winners in National Research Conferences of Minority Pharmacy Researchers.Deans Prize winner for outstanding research in graduating class.

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Deandra Dixon. Pharm .D- 2001 Published work

MEMBERSHIP OF ACADEMIC/ PROFESSIONAL ASSOCIATIONS.

Member, Nigerian Medical Association- 1980Member, Glasgow Clinical Pharmacology Group- 1982Member, New York Academy of Science – 1984Member, British Pharmacological Society- 1986Member, Nigerian Cardiac Society- 1989Member, Association of Hospital Consultants- 1989Member, West African Society for Pharmacology- 1990Member, American Society for Clinical Pharmacology and Therapeutics -

1993Member, American Federation for Clinical Research (Complimentary

membership)- 1994Member, American Association for the Advancement of Science- 1994Member, Nigerian Hypertension Society- 1995American Physiological Society- 2000Great Ife Alumni Association (USA)-2000Member, Houston Local Authors Society- 2001Member, International Society of Hypertension in Blacks (ISHIB)-2001Member, American Diabetic Association.- 2002.EuroMD Net organization – 2006 ( network of physicians , physician –

scientists, industry)18. Index Copernicus -2006 (Invited Membership to impactful researchers in the sciences)

EDITORIAL REVIEW FUNCTION

Associate Editor, Nigerian Medical Journal. 1997- 2007Editorial board member, West African Journal of Pharmacology.

1990-95.Reviewer: Journal of Hypertension, African Journal of Medicine and Medical

Sciences. American Journal of Cardiovascular Drugs, Ethnicity and Disease.Journal of the National Medical Association.- 1991-2001

Reviewer for American Journal of Cardiovascular Drugs- 2001Reviewer, Clinical Pharmacology & Therapeutics- 2001Reviewer, The Wellcome Trust Grants UK.- 2002.Reviewer - Diabetic Medicine. –2002, 2003, 2009Reviewer, Pharmacology, Biochemistry & Behavior –2004. Borno Medical Journal-Editorial board- 2004.Current Diabetes Reviews – Editorial board – 2004-date.

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The Open Journal of Heart Failure –Editorial Board -2008-dateReviewer –Journal of pharmacy and pharmacology-2006Reviewer – Journal of Cardiovascular Pharmacology- 2006, 2007,

2009,2010Reviewer – Journal of infectious Disease-2006Reviewer - International Journal of Cardiology -2006, 2007, 2008,

2009,2010, 2011.Reviewer – Circulation – 2006, 2007, 2008, 2009, 2010, 2011.Reviewer – Archives of Drug Information – 2007, 2008, 2009. Reviewer - Gender Medicine-2007,2008Reviewer – Malaria journal (France)-2007Reviewer – Journal of Sexual Medicine -2009Reviewer – American Journal of Nephrology -2009Reviewer – Case studies in Medicine -2009Reviewer – Platelets-2010Reviewer - Metabolic Brain Disease-2011Reviewer - Cardiovascular Journal of Africa (South Africa) -2014, 2015

EXTERNAL EXAMINERSHIPSUniversity of Ibadan, Faculty of Medicine- Pharmacology & Therapeutics

1996-98.University of Nigeria, Faculty of Medicine- Pharmacology & Therapeutics

1989-91.University of Benin, Faculty of Medicine- Department of Medicine, 1998.

Synergistic and Miscellaneous activitiesAcademic Prizes Donated :

Adeline and Alex Olu Ajayi Prize – For the best student in Physiology at the Obafemi Awolowo University Medical School, ile-Ife, Nigeria.-1997

Dr Edward Adefemi Oyewo Prize (in conjuction with Pfizer Nigeria PLC) – For the best student in the Clinical pharmacology course at the Faculty of Pharmacy, Obafemi Awolowo University, Ile Ife, Nigeria.-1996

Grillo-Durotoye Prize – For excellent, novel and significant research publication in the biomedical and clinical sciences or public health by Faculty at the Obafemi Awolowo University, Ile-Ife, Nigeria- 2001 Scholarship inaugurated and awarded continually -Trustee

The Adeline Olu Ajayi University Scholarship for children of Police officers- Lagos Police Command Area – Surulere/Bode Thomas, Lagos state -Nigeria . –since 2007.

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PUBLICATIONS:1. Thesis/Dissertation:“Studies on Somato-Visceral Reflexes in the rat.” B.Sc (Health Sciences)-

1977.“Typhoid Enteropathy in Ile-Ife in 1980” – Final M.B. Ch. B Community

Medicine Dissertation- 1980

“Clinical and Pharmacological Studies on Angiotensin- I Converting Enzyme Inhibitors”- Ph.D. Thesis- 1985.

“Enalapril in hypertension and heart failure in Nigerians”- Final F.W.A.C.P. Dissertation- 1989.

2. Books/ MonographsAuthored Books:A Handbook of Rapid Bedside Physical Examination and

Pathophysiology College Press (Ltd.) Ibadan, Nigeria 1995 ISBN 978-2194-05-0. Author A.A. Ajayi .

Angiotensin converting enzyme inhibition in Nigerians 1997. A.A. Ajayi

Diaspora Medicine. ISBN-0-971043-0-1-2001. AJAYI AA. A fully referenced 458 page textbook of internal medicine, psychiatry, dermatology, physical examination, clinical pharmacology, therapeutics and toxicology. It emphasizes ethnic variation in disease pathophysiology, presentation and response to therapy. Has 100 pages on clinical pharmacology and clinical pharmacokinetics and drug metabolism. Leslie Academic Press, Houston , USA and Obafemi Awolowo University Press, Ile-Ife, Nigeria. Reprinted 2013 : Amazon .com

Immigration and Health . Authorhouse Inc. ISBN 978-1-4343-9129-2 By Adesuyi A L Ajayi & Abimbola T Ajayi-2008 E –BOOK VERSION – 2012 Immigration and health USA by Smashword.

Edited Books“Cardiology: Review and Update”- Ajayi A.A. editor, West African College

of Physicians, 1990, Lagos, Nigeria.

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“Cardiology” 1993- R.O. A. Makanjuola & A.A. Ajayi ed., Shaneson Press Ltd., Ibadan, ISBN 978-240-041.

Contributions to books:A.A. Ajayi et al. “Androgen regulation of thromboxane A2 recptors: In, Advances in Prostaglandins, Thromboxanes and Leukotriene Research, 1994, 251-253, Vol 21, Raven Press, New York, Ed. Samuelsson B. et al.

Ajayi AA. “Hypertension- Treating patients, not just pressures” Chapter 7. Cardiology 1993. Makanjuola RO & Ajayi (editors) Shaneson press Ltd. Ibadan.

Ajayi AA. “Vasodilators, Intropes and thrymbolytic agents” Chapter 9. Cardiology 1993. Makanjuola RO & Ajayi (editors) Shaneson press Ltd. Ibadan.

Ajayi AA “Clinical Pharmacology in the treatment of cardiac disease” Cardiology Review and Update- Ajayi AA (Editor) West African College of Physicians 1990, Lagos.

Sofowora GG, Ajayi AA. Medical Treatment of Heart Failure . 1.

Technical Reports :

The effect of age on the pharmacokinetics and pharmacodynamics on ACEI enalapril, enalaprilat. –submitted to Merck co . Rahway , NJ. USA.

The effect of S-9490-3 on autonomic function in healthy volunteers – Servier , France.

Pharmacodynamics, dose response relationships, and autonomic function after cilazapril. – submitted to Hoffman la Roche. Basel , Switzerland.

The effect of naloxone on the actions of captopril . Prepublication report sent to Dupont Chemicals, NJ . USA.

The effect of lacidipine in hypertensive Nigerians – submitted to Glaxo Smith Kline

Comparison of cilazapril, hydrochlothiazide and their combination in hypertensive Nigerians. Hoffman la Roche, Basel Switzerland.

GrantsCo-Investigator . Texas Southern University Research Scientist Grant (Center Grant) from the National Institutes of Health (NIH) 1999-2004. $300,000 peranum Direct cost. Head of Head of the Hypertension Research

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section. DR AO Oyekan – Principal INVESTIGATOR

Published Peer Reviewed Journal Articles:

Ajayi AA. Campbell, B.C., Howie, C.A.,Reid, J.L : Acute and chronic effects of angiotensin converting enzyme inhibitors, enalapril and lisinopril on the reflex control of heart rate in normotensive man. Journal of Hypertension, 1985, 3, 47-53.

Ajayi A.A., Campbell B.C. Meredith P.A., Kelman, A.W. And Reid J.L. : The effect of captopril on reflex control of heart rate: Possible mechanisms.

British Journal of Clinical Pharmacology, 1985, 20, 17-25.

Ajayi A.A., Campbell B.C, Howie C.A., Kelman, A.W., Meredith P.A. And Reid J.L. The pharmacodynamics and population pharmacokinetics of enalapril and lisinopril . International Journal of Clinical Pharmacological Research . 1985, V (6), 419-427.

Andy J.J., Ladipo G.O.A., Owolabi S.P., Teniola S.O., Ajayi A.A., Akinola N.O and Morakinyo O. Blood pressure distribution of Nigerians in the first two decades of life. Annal of Tropical Pediatrics.1985, 5, 113-118.

Ajayi A.A., Campbell B.C., Rubin P.C., and Reid J.L. : Effect of naloxone on the actions of captopril. Clinical Pharmacology and Therapeutics, 38, 1985, 560-565.

Ajayi A.A., and Reid J.L. The effect of enalapril on baroreceptor mediated reflex function in normotensive subjects. British Journal Clinical Pharmacology, 1986, 21, 338-339.

Hockings N. Ajayi A.A. and Reid J.L. : Age and the pharmacokinetics of angiotensin converting enzyme inhibitors, enalapril and enalaprilat.

British Journal of Clinical Pharmacology, 1986, 21, 341-348.

Ajayi A.A., Hocking N. and Reid J.L. Age the pharmarcodynamics of angiotensin converting enzyme inhibitors, enalapril and enalaprilat.

British Journal of Clinical Pharmacology, 1986, 21, 349-357.

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Ajayi A.A., Lees K.R. and Reid J.L. (1986): Effects of angiotensin converting enzyme inhibitor, perindopril on autonomic reflexes.

European Journal of Clinical Pharmacology, 30, 177-182.

Ajayi A.A, Rubin P.C. and Reid J.L. : Captopril and opiate antagonism in essential hypertension. British Journal of Clinical Pharmacology, 1986, 21, 543-545.

Ajayi A.A., Elliot H.L. Reid J.L. : The pharmacodynamics and dose-response relationships of angiotensin converting enzyme inhibitor, cilazapril in essential hypertension. British Journal of Clinical Pharmacology, 1986, 22, 167-175.

Ajayi A.A., Hocking N., and Reid J.L. (1987): The relationship between serum enalaprilat concentrations the hypotensive effect in man.

International Journal of Clinical Pharmacology Research. 1987, 7(1) 1-3.

Ajayi A.A., and Reid J.L. Renin- Angiotensin- modulation of sympathetic reflex function in essential hypertension and in the elderly. International Journal of Clinical Pharmacology Research, 1988, 8(5) 327-333.

Ajayi A.A. Parasympathetic cardiac activity: Differential effects of aging and hypertension. East African Medical Journal. 1988. 65(8), 520-524.

Balogun M.O., Ajayi A.A., Ladipo G.O.A. Spectrum of treadmill exercise responses in Africans with normotensive, essential hypertension and hypertensive heart failure. International Journal of Cardiology, 1988, 21 (3), 293-300.

Ajayi A.A., Balogun M.O., Ladipo G.O.A. : Vasodilator therapy with angiotensin converting enzyme inhibitor in chronic heart failure: Treadmill exercise response in Nigerians. Cardiologie Tropicale- Tropical Cardiology, 1988, 15(57), 19-23.

Ajayi A.A. Balogun M.O. Oyewo E.A. Ladipo G.O.A. (1989): Enalapril in African patients with congestive cardiac failure. British Journal of Clinical Pharmacology. 27, 400-403.

Ajayi A.A., Oyewo E.A. Ladipo G.O.A. and Akinsola A. Enalapril and hydrochlorothiazide in hypertensive Africans. European Journal of

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Clinical Pharmacology. 1989, 36, 229-234.

Ajayi A.A. and Reid J.L. Cardiovascular and endocrine effects of cilazapril, a new ACE-inhibitor in man. African Journal of Medicine and Medical Sciences 1989(1) 33-38.

Ajayi A.A, Oluokun A.R., Sofowora O, Akinleye A, Ajayi A.T. Epidemiology of anitmalarial-induced pruritus in Africans. European Journal of Clinical Pharmacology, 1989, 37(5), 539-540.

Elliot H.L., Ajayi A.A., Reid J.L. The influence of cilazapril on indices of autonomic function in normotensives and hypertensives. British Journal of Clinical Pharmacology, 1989, 27,303s-307s.

Oyewo E.A., Ajayi A.A., and Ladipo G.O.A. A therapeutic audit in the management of hypertension in Nigerians. East African Medical Journal, 1989, 66(7), 458-467.

Ajayi A.A., Balogun M.O., Ajayi A.T. : Correlation among radiologic, echocardiographic indices and self-paced exercises capacity in heart failure. International Journal of Cardiology, 1990, 27(1), 136-137.

Ajayi A.A., and Ajayi A.T. Angiotensin converting enzyme inhibition reduces proteinuria in Nigerians with chronic renal disease. European Journal of Clinical Pharmacology, 1990, 39(4), 423-424.

Ajayi A.A. and Ukponmwan O.E. Evidence of angiotensin-II and endogenous opioid modulation of novelty-induced rearing in the rat. African Journal of Medicine and Medical Sciences, 1994, 23, 287-290.

Ajayi A.A., Balogun M.O. Sustained beneficial effects of enalapril in Africans with congestive heart failure. International Journal of Cardiology, 1990, 29(1), 55-61.

Ajayi A.A. Angiotensin converting enzyme inhibitors in cardiovascular and renal disease in Africans: A review. African Journal of Medicine & Medical Sciences, 1991, 20, 123-134.

Adamolekun B., Ajayi A.A., Primary writing tremor in a Nigerian: Role of tremorogenic beta-adrenoceptors. Nigerian Medical Practitioner. 1990, 20(4), 83-86.

Ajayi A.A. Estimation of creatinine clearance: Utility of the Cockcroft and Gault equation in Nigerian patients. European Journal of Clinical Pharmacology, 1991, 40,429-431.

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Ajayi A.A. and Babalola R.O. : Enalapril and hydrochlorothiazide combination in hypertensive-diabetic Africans with proteinuria. International (Practical) Diabetes Digest, 1991 2(2), 51-52.

Ajayi A.A. Akinleye A.O., Udoh S.J., Ajayi O.O., Oyelese O., Ijaware C.: The effect of Predinsolone and Niacin on Chloroquine-induced pruritus in malaria.

European Journal of Clinical Pharmacology, 1991, 41, 383-385.

Ajayi A.A., and Balogun J.A. Symptom-linked, self-paced walking in the assessment of cardiovascular disease: predictive value of echocardiographic, clinical and ergonometric parameters. International Journal of Cardiology, 1991, 33, 233-240.

Ajayi A.A., Akintomide A.O., Babalola R.O. and Akinwusi P.O. : Disproportionate intraventricular septal hypertrophy in Nigerians with essential hypertension.

African Journal of Medicine and Medical Sciences, 24, 1994, 93-96.

Balogun J.A., Isi J., and Ajayi AA: Cardiovascular effects of the inversion of the head. Journal of Physiotherapy Science. 1992, 4, 1-11.

Ajayi A.A., Akinsola A., Ajayi A.T. and Sanusi O. Problem of follow-up of renal transplant recipients in the tropics. Trop & Geogr. Med., 44(2), 1992, 170-173.

Ajayi A.A. and Akinwusi P.O. : Spectrum of hypertensive heart disease in Nigerians: A cross-sectional study of echocardiograpbic indices and the correlation to treadmill exercise capacity. Journal of Hypertension, 1993, 11, 99-102.

Babalola R.O. and Ajayi A.A.A cross-sectional study of echocardiographic indices, treadmill exercise capacity and microvascular complications in hypertensive diabetic Nigerians. Diabetic Medicine, 1992, 9. 809-903.

Ajayi A.A., Oshodi O., Akintomide A.O. : The influence of captopril on intrahospital mortality and duration of hospitalization in Nigerians with congestive heart failure. International Journal of Cardiology, 1992, 36, 341-343.

Durosinmi M.A. Ajayi A.A. : A prospective study of Chloramphenicol- induced aplastic anemia in Nigerians. Trop. Geogr. Med., 1993, 45, 159-

17

161.

Balogun A., Oyeyemi O., Ajayi A.A. : Effects of aerobic training on the cardiovascular response to head-down posture. J. Phys. Ther. Sci., 1993, 5,1-12

Oyelola O.O., Ajayi A.A., Stein R. and Babalola R.O. Lipids, Lipoprotein and apoprotein profiles in hypertensive, diabetic and hypertensive-diabetic Nigerians.

J. Natl. Med. Assoc., 1995, 87, 113-118

Ajayi A.A., Raji M.A. : Acute cardiovascular effects of the concurrent administration of enalapril, amlodipine or prazosin in healthy Nigerians

International Journal of Cardiology, 1994, 44, 79-84.

Ajayi A.A., and Akintomide A.O. The efficacy and tolerability of amlodipine and hydrochlorothiazide in Nigerians with Essential hypertension. J. Natl. Med. Assoc. 1995, 87, 485-488.

Ajayi A.A., Antiarrhythmic action of enalapril in congestive heart failure: Possible contribution of altered sympathovagal autonomic balance on the heart. Int. J. Cardiol., 1994, 47, 195-196.

Ajayi A.A. Mathur R., Halushka P.V. (1995): Testosterone Increases human platelet thromboxane A2 receptor density and aggregation responses. Circulation, 91, 2742-2747.

Ajayi A.A. (1995): Increase in plasma B-endorphins precedes vasodepressor syncope (Letter) Br. Heart Journal. 73(5), 488-488.

Ajayi A.A Fox S.C., Rubin P.C., Allen B.R. (1995): A study of the possible role o the 12-lipogenase pathway in Chloroquine pruritus. Niger. Med. J. 1995, 29, 2, 78-79

Ajayi A.A. Sofowora G.G., Balogun M.O.: Clinical Implications of the inhibitions of the “cross-talk” between α-1 adrenoceptor blockade and converting enzyme inhibition in the treatment of heart failure. Afr. J.

18

Med. & Med. Sci, 1996, 25,95.

Ajayi A.A., Afolabi M.A., Balogun M.O., Adigun AQ, Akintomide AO. Oral therapy with combined enalapril, prazosin and hydrochlorothiazide in the acute treatment of severe hypertension in Nigerians. Eur. J. Clin Pharmacol. 1996, 51, 45-48.

Ajayi A.A, Sofowora GG, Balogun M.O.: Concurrent α-1 adrenergic blockade and ACE-inhibition in the treatment of congestive heart failure.

International Journal of Cardiology. 1996, 57 173-176.

Adewole A.D., Ikem R.T., Adigun A.Q., Akintomide A.O., Balogun M.O., Ajayi A.A.L Three year review of the impact of ACE-inhibitiors on intra-hospital mortality of Nigerians with chronic heart failure, Central African Journal of Medicine, 1996 42. 253-255.

Ajayi A.A., Horn E.H., Rubin P.C.: Evidence of increased platelet activation in vivo, during heparin prophylaxis of venous thrombosis in pregnancy . Afr. J. Med & Med. Sci. 1999, 28, 113-115

Adebayo R., Sofowora G.G., Onayemi O, Udoh S.J. Ajayi A.A. Chloroquine-induced pruritus in malaria: Role of malaria parasitemia and the effects of Prednisolone, Niacin and the combination compared to anithistamines. Br. J. Clin. Pharmacol 1997, 44, 157-161.

Ajayi A.A : Novel aspects of the molecular and clinical pharmacology of ACE-inhibition relevant to cardiovascular diseases Nigerian Medical . Journal . 1996,31,45-51

( State –of the Art Lecture)

Ajayi A.A., Olotu T.C., Sofowora G.G. Knowledge attitude and practice of prednisolone prevention of chloroquine-induced pruritus among Nigerian Health WorkersTropical Doctor 1998, 28(4), 210-211

Rotimi O. Ajayi A.A., Odesanmi W.O: Sudden unexpected death due to cardiac causes in Nigerians: A review of 50 autopsied series. Int J Cardiol 1998, 63, 111-115.

Sofowora GG, Adigun AQ, Haastrup AT, Ajayi AA. Evidence of synergism between ACE inhibitor and alpha-1 antagonist during Isometric handgrip in normal man. Cardiologie Tropicale- Tropical Cardiology. 1998, 25 (96) 111.

19

Adigun AQ, Ajayi AA.: Muscarinic blockade with Oral hyoscine palliates ACE-inhibitor induced cough, Afr J Med Med Sci. 1998, 27, 139.

Adigun A.Q. Ajayi AA. Accidental overdose with enalapril and prazosin. Nigeria Medical Practitioner 1997, 34, 56-57.

Kolawole BA, Ajayi AA. Prognostic indices for hospital mortality in hypertensive diabetic Nigerians. Diabetes International 1998, 12(3) 77-81.

Adigun AQ, Ajayi OE, Sofowora GG, Ajayi AA. Vasodilator therapy of hypertensive acute pulmonary edema. Comparison of captopril- prazosin and hydralazine- isosorbide dinitrate. International Journal of Cardiology. 1998, 67, 81-86.

Kolawole B, Ajayi AA. Prognostic Indices of intra-hospital mortality in hypertensive diabetic NIDDM Nigerians: Role of gender and hypertension.

J Diabetes Complications. 2000, 14, 83-87.

Olateju SO, Ajayi AA. Lack of efficacy of β- adrenergic-blockers .timolol and betaxolol on intraocular pressure in healthy Nigerians. Eye 1999. 13, 758-63. [ Rated Best paper of the year in the journal Eye , Journal of the Royal College of ophthalmologists]

Ajayi AA, Adigun AQ, Ojofeitimi EO, Yusuph H, Ajayi OE. Anthropometric evaluation of cachexia in chronic congestive heart failure heart failure : Role of tricuspid regurgitation. International Journal of Cardiology 1999, 71, 79-84.

Onigbogi O. Ajayi AA. Ukponmwan OE. Chloroquine induced body scratching behavior in rats: evidence of involvement of endogenous opioid peptides.

Pharmacology Biochemistry & Behavior 2000, 65, 333-337.

Sanusi AO, Akinsola A. Ajayi AA. Prediction of creatinine clearance from serum creatinine in Nigerians: A comparison of the predictive accuracy of five formulae. African Journal of Medicine & Medical Sciences, 2000,

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29, 163-167.

Adigun AQ, Sofowora GG, Ajayi AA. Chronotropic atropine dose response in congestive heart failure; Assessment of interethnic variation and the reversibility of parasympathetic dysfunction. Ethnicity and Disease 2000, 10, 203-207.

Ajayi AA, Adigun AQ, Angiodema and cough in Nigerian patients receiving ACE inhibitors. British Journal of Clinical Pharmacology, 2000, 50, 81-82.

Ajayi AA. Mechanisms of Chloroquine induced pruritus. Clin Pharmacol Ther 2000 68, (3) 336-7.

Adigun AQ & Ajayi AA. The effect of enalapril-digoxin-diuretic combination on the nutritional and anthropometric indices in congestive heart failure: preliminary findings in cardiac cachexia. European Journal of Heart Failure 2001, 3, 359-363.

Adigun AQ & Ajayi AA A prospective study of ACE inhibitor- induced cough in Nigerians West African Journal of Medicine, 2001, 20, 46-7.

Ajayi AA, Hercule HC, Pamugo J, Dixon D, Oyekan AO. Interactions of the renin-angiotensin system and alpha-1 adrenoceptors on renal hemodynamics in healthy and acute renal failure rats. Blood Pressure 2001, 10, 238-246.

Hercule HC, Ajayi AA, Oyekan AO. Differential effects of U46619 on renal regional blood flow; Evidence for the involvement of endothelin-1. J Pharmacol Exp Ther 2001, 299, 372-6.

Ajayi AA, Adigun AQ, Syncope after oral chloroquine administration in hypertensive patient controlled on amlodipine. Br J Clin Pharmacol, 2002, 53 , 404-5.

Adigun AQ, Asiyanbola B, Ajayi AA, Cardiac autonomic function in blacks with congestive heart failure: vagomimetric action, alteration in sympathovagal balance, and the effect of ACE inhibition on central and peripheral cardiac vagal tone.

Cell Molecular Biology, 2001, 47, 1063-1067.

Ajayi AA, Sofowora GG, Adigun AQ, Asiyanbola B. Adjunctive sympathoplegic therapy to ACE inhbition in blacks with congestive heart failure: A comparison of alpha-1 with beta-1 blockade on exercise

21

tolerance and cardiac sympathovagal reflex activity. Ethnicity & Disease 2003 13 (1) 71-79

76 Ajayi AA, Sofowora GG, , Adigun AQ, Asiyanbola B. New treatments for blacks with heart failure : for the patient. Ethnicity & Disease 2003, 13, 150

Ajayi AA., Hercule HC., James Cory, Hayes BE. Oyekan AO. Gender differences in the vascular and platelet reactivity to TXA2 mimetic U46619 and to endothelial dependent vasodilation in Zucker fatty (hyperinsulinemic, hypertensive) diabetic rats.

Diabetic Research and Clinical Practice 2003, 59, 11-24.

Ajayi AA, Newaz M, Saleh M, Hercule C, , Bode C, Oyekan AO. Endothelin-1 like action of an aqueous extract of Pausinystalia yohimbie on renal medullary blood flow and blood pressure in Sprague- Dawley rats. Methods & Findings in Exp & Clin Pharmacol . 2003, 25, 817-822.

Adigun AQ, Ishola DA, Akintomide AO, Ajayi AAL. Shifting trends in the pharmacological management of essential hypertension in a Nigerian tertiary hospital. : a real world evaluation of the cost-effectiveness, safety, efficacy rationality, of new and older antihypertensive agents. J Human Hypertension. 2003 , 17, 277-85

Ajayi AAL. Recommendations for prevention, diagnosis and management of hypertension and cardiovascular risk factors in SubSaharan Africa. [ Comments ]Journal of Hypertension 2004 22, (5) 1047.

Ajayi AA, Ogungbade O, Hercule HC, Oyekan AO, Mutembei L . Altered endothelin-receptor subtype responsiveness and ET-1 –TXA2 receptor interaction in hypertensive –diabetic Zucker rats. Diabetes Research and Clinical Practice 2004 63 (3) 155-169

Ajayi AA. , Kolawole BA Sickle cell trait and gender influence complications in Africans with type-2 diabetes .Eur J Intern Med 2004 , 15 (5) 312-5.

83.Ajayi AA, Kolawole BA, Udoh SJ. A double-blind controlled study of the antipruritic efficacy

of μ opiate receptor antagonist, naltrexone, and promethazine on

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chloroquine induced pruritus in malaria fever. Inter J Dermatology 2004, 43,972-7

84. Ajayi AA, Ogungbade GO, Okorodudu AO. Sex hormone regulation of systemic

vascular endothelial and renal microvascular reactivity in Zucker diabetic rats . Eur J Clin Invest 2004 , 34, (5) 349-57.

85. Ajayi AA. Gender influences the impact of sickle cell trait on Type-2 diabetes

complications. Diabetic Medicine 2005 , 22 (7) 954.

86. Ajayi AA, Fidelis P, The effect of flutamide on systemic and renal hemodynamics in Zucker diabetic rats : paradoxical renal vasodilator response to ET-1 and TXA2 receptor activation in female gender. J Cardiovasc Pharmacol 2006, 48(5) 191-8.

87.Ajayi AA. Impact factor misleading, citing all references.. J Natl Med Assoc, 2004, 96, 1374

88..Ajayi AA, Halushka PV. Castration reduces human platelet TXA2 receptor density and aggregability. QJM 2005, 98 ( 5) 349-56.

Ajayi AA. Should Sickle cell trait be re-classified as a disease state ? Eur J intern Med 2005 , 16 (6) 463.

90. Ogunbodede EO, Fatusi OA, Akintomide A, Kolawole K, Ajayi A . Oral health status in a Population of Nigerian Diabetics.   J Contemp Dental Pract 2006 (6)4:075-084. 91.Ajayi AA. Singh D. First line treatment with beta-blockers followed by adjuvant ACE-

inhibitors after six months may be safe in older people with heart failure Evidenced-based Cardiovascular Medicine 2006, 10, 21-3.

92. Ajayi AA, Cooper J, Horn EH, Rubin PC. Comparison of the effects of unfractionated heparin and the low molecular weight heparins, dalteparin and enoxaparin on spontaneous platelet aggregation, and adenosine diphosphate activity in platelets during the third trimester of pregnancy. Methods & Find Experimental Clin Pharmacol 2007, 29: 539-45.

93. Ajayi OE, Akintomide AO, Adigun AQ, Ajayi AAL. Left ventricular diastolic function

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in hypertensive Nigerians ; effects of ACE Inhibitors, Calcium antagonists or their combination. Arch Drug Inf, 2008, 1.(1) : 29-34

94.. Ajayi OE, Abiona TC, Balogun MO, Ajayi AAL . Valvular

regurgitation impact on left ventricular 2 dimensional and Doppler echocardiographic indices in Nigerian patients with essential hypertension. J Natl Med Assoc, 2010; 102 : 937-42.

95. Ajayi OE, Ajayi AA. Valvular regurgitations may increase risk of arrhythmias in hypertensive heart failure in Nigerians . J Cardiovasc Med (Hagerstown )2013, 14(6) 453-60.

96. Ajayi OE, Balogun MO, Abiodun G, Adebayo RA, Ogunyemi S, Akintomide AO, Bamikole J, Ajayi AA. Patterns of arrhythmias in Nigerians with congestive heart failure. Int J Gen Med (2015) in press.

97.. Ajayi OE, Ajayi AAL . The correlation of echocardiographic indices with left atrial and ventricular arrhythmias by 24 hour EKG Holter monitoring in hypertensive heart disease and hypertensive heart failure in black West Africans. Journal of Preventive Cardiology 2015, 4,(3) 698-705.

98. . Olateju SO, Ajayi AA. The effects of combigan on intra-ocular pressure in Nigerian healthy volunteers. 2014 Arch ophthalmology (submitted)

99. Ajayi AA The beneficial parasympathetic cardiovascular actions of inhibitors of the Renin-Angiotensin –System . Current Clinical Pharmacology Reviews –invited reviews 2014

100. Sofowora GG, Ajayi AA . Treatment of Congestive heart failure in Nigerians. Book Chapter in Management of Heart Failure ; Medical. Volume 1. By Ragavendra Baliga & Garrie Haas . 2014 in press . ( Springer ).

101. Kolawole BA, Ajayi AA et al Comparison of the effects of hydrochlorothiazide and ACEI lisinopril, thiazide combination on HOMA Beta cell function and insulin secretion in blacks with Essential hypertension. Diabetes Obesity Metabolism (submitted )2014.

PUBLISHED CONFERENCE PROCEEDINGS AND ABSTRACTS

Ajayi A.A., Balogun M.O., Oyewo E.A. and Ladipo G.O.A. (1988): Angiotensin converting enzyme inhibition with enalapril in Nigerian patients with

24

congestive heart failure. Proceedings of the 17th Annual Scientific Meeting of the Nigerian Cardiac Society, Ibadan, Abstract No. 14.

Balogun M.O., Ajayi A.A. Ladipo G.O.A. (1988): Spectrum of exercise treadmill responses in normotension, essential hypertension and hypertensive heart failure. Proceedings of the 17th Annual Scienitic Meeting of the Nigerian Cardiac Society. Ibadan, Abstract No. 17.

Ajayi A.A. (1989): Enalaprilat concentration effect modeling. 1st Intenational Symposium on Heart Failure. Mechanisms and Management, Jerusalem, Israel. Abstract Poster 109.

Balogun M.O. and Ajayi A.A. (1989): Spectrum of treadmill responses in Africans. 1st international Symposium of Heart Failure: Mechanisms and Management. Jerusalem, Israel. Abstract Book P. 108.

Ajayi A.A., Balogun M.O. and Ladipo G.O.A. (1989): Possible Mechanisms of ACE-inhibitors reduction of sudden cardiac death. 18th Annual Scientific Meeting of Nigerian Cardiac Society, Lagos. Abstract No. 5.

Ajayi A.A. and Ukponmwan O.E. (1989): Angiotensin system modulates novelty induced rearing in rats. Proceedings- West African of Pharmacology, 030, Port Harcourt, Nigeria.

Ajayi A.A. Akinsola A., Ogunrin O. and Adegbulugbe S.A. (1989): Enalapril with standard therapy in resistant hypertension and chronic renal failure in Nigerians. Proceedings of 2nd Nigerian Association of Nephrology Conference, Lagos, Nigeria, P. 12.

Ajayi A.A. and Ukponmwan O.E. (1990): Evidence of angiotensin-II modulation of novelty induced rearing in the rat. European Journal Pharmacology, 183, 504-5

Ajayi A.A. and Balogun M.O. (1990): Inhibition of angiotensin converting enzyme in heart failure in Nigerians. 19th AGM and Scientific Conference, West African Society for Pharamcology. Lagos, P.4.

Ajayi A.A., Oyewo E.A., Balogun M.O. (1990): The clinical pharmacology of enalapril. Scientific Conference in honor of Professor T.A.I. Grillo O.A.U. Ile-Ife. CS.4. (Feschcrift)

Ajayi A.A. Campbell B.C., Howie C.A., Reid J.L. (1984): Acute and chronic

25

effect of enalapril and MK 521, on reflex control of heart rate in normotensive subjects. Proceedings of the British Pharmacological Society (BPS), London, 1984. British Journal of Clinical Pharamcology, 17, 607-608p.

Ajayi A.A., Campbell B.C., Kelman A.W. Howie C.A., Miller J.A. and Reid J.L. (1984): Enalapril and lisinopril: Pharmacodynamics and population pharmacokinetics. BPS Proceedings, Birmingham 1984 British Journal of Clinical Pharmacology, 18, 273-274p.

Ajayi A.A. Campbell B.C., Meredith P.A., Reid J.L (1984): Mechanisms of the parasympathetic activity of angiotensin converting enzyme inhibitor in man. Proceedings of the 9th International Union of Pharmacology Congress (IUPHAR) London, abstract 936.

Hockings N., Ajayi A.A., Hughes D.M. Lees K.I.R. Reid J.L. (1985): The effect of age on the pharmacodynamic response to angiotensin converting enzyme inhibitors enalapril and enalaprilat. BPS Proceedings, Dundee, 1984. British Journal of Clinical Pharmacology, 19, 140-141p.

Ajayi A.A., Campbell B.C., Rubin P.C. Reid J.L. (1985): Endogenous opioids and central actions of captopril in man? Proceedings of 2nd European Meeting of Hypertension, Milan, Italy, Abstract No.3.

Lees K.R. Ajayi A.A. Reid J.L (1985): Effect on blood pressure and renin-angiotensin system of S-9490-3, a new angiotensin converting enzyme inhibitor. Proceedings of 2nd European Meeting on hypertension. Milan, Italy, 1985. Abstract No. 298.

Hockings N. Ajayi A.A Reid J.L. (1985): The effects of age on the pharmacokinetics and dynamics of angiotensin converting enzyme inhibitors, enalapril and enalaprilat. BPS Proceedings, Cardiff, 1985. British Journal of Clinical Pharmacology, 20,262p.

Ajayi A.A., Campbell B., Gilbert L., Summer D.J. Rubin P.C. and Reid J.L (1985): The actions of naloxone on the cardiovascular and autonomic effects on captopril in man. BPS Proceedings, Cardiff, 1985. British Journal of Clinical Pharmacology, 20.262p-263p.

Andy J.J. Ladipo G. Teniola S. Ajayi A.A. Akinola N.O. and Owolabi S.P (1983):

Blood pressure in 4,464 Nigerian children and young adults aged 1-20 years. Proceedings of the 12th Annual Meeting of the Nigerian Cardiac Society.

26

Ile-Ife, P.19.

Ajayi A.A. Elliot H.L., Hughes D.M., McCulloch J., Reid J.L. (1986): Pharmacodynamics and dose response relationship of angiotensin converting enzyme inhibitor, cilazapril in essential hypertension. Proc of Joint Italian Pharmacological Society and BPS Meeting, Edinburgh, 1985. British Journal of Clinical Pharmacology, 21, 92p.

Oyewo E.A., Ajayi A.A., Ladipo G.O.A. (1987): A therapeutic audit in the management of essential hypertension. Proceedings of 16th Annual meeting of the Nigerian Cardiac Society, Calabar, P. 19.

Ajayi A.A., Ladipo G.O.A., Oyewo E.A., Akinsola A. (1987): Enalapril an angiotensin converting enzyme in hypertensive Nigerians, proceedings of 12th Annual Scientific Meeting of the West African College of Physicians,Lagos, P.19.

Ajayi A.T., Balogun M.O., Ajayi A.a, (1990): Chest X-ray and echocardiopgraphy prediction of self-paced exercise to tolerance on myocardial oxygen consumption in heart failure. Scientific Conference in honor of Professor T.A.I. Grillo, Ile-Ife, CS. 11. (Feschcrift)

Ajayi A.A., Balogun J.A. (1991): Symptom-limited, self-paced walking in the functional capacity evaluation in cardiovascular disease. 20th Annual Scientific Conference of Nigerian Cardiac Society, Benin, 1991, Abstract No. 8p.

Babalola R.O., Ajayi A.A. (1991): Haemodynamic study on hypertensive diabetic Nigerians. 20th Annual Scientific Conference of Nigerian cardiac Society. Benin, 1991. Abstract No 8p.

Akinwusi O. Ajayi A.A. (1991): Haemodynamic spectrum of hypertensive heart disease in Nigerians. . 20th Annual Scientific Conference of Nigerian cardiac Society. Benin, 1991. Abstract No 3p.

Babalola R.O. Ajayi A.A., Oyelola O.O. (1991): Target organ damage and hyperlipidaemia in hypertensive-diabetic Africans. Third International Symposium on Hypertension Associated with Diabetes Mellitus, Boston MA, USA. Abstract N. 110.

Ajayi A.A., Raji M.A. Akintomide A.O., Babalola R.O. (1992): The cardiovascular effects of the concurrent administration of ACE inhibitor,

27

calcium antagonist and adrenergic antagonist in healthy Africans, BPS Proceedings, Newcastle, April 1992. British Journal of Clinical Pharmacology. 34, 17p.

Ajayi A.A., Copper J.A., Rubin P.C., Horn E.H. (1993): Effects of unfractionated heparin and the low molecular weight heparins, dalterparin and enoxaprin on platelet behavior in pregnancy. 24th International Society of Hematology Congress, London Sept. 1992. Abstract No. 347A.

Ajayi A.A. Cooper JA, Horn EH , Rubin PC. (1993). The effects of unfractionated

heparin and the low molecular weight heparins, dalterparin and enoxaprin on platelet behavior in pregnancy. British Journal of Clinical Pharmacology 35, 90-91P.

Ajayi A.A. Mathur R. Halushka P.V. (1994): Testosterone increase human platelet thromboxane A2 receptor density. Clinical Research , 42(2), 252A.

Halushka P.V., Ajayi A.A., Mathur R. (1994) : Testosterone increase human platelet TXA2 receptor density. 9th International Conference on prostaglandins and related compounds. Florence, Italy, June 6-10, P.28

Halushka P.V., Ajayi A.A., Schror K, Matsuda K. Masuda A., Mathur R. (1994): Cardiovascular TXA2 receptor regulation by sex steroids. Mediators in cardiovascular system. International Conference, June 2-5. Malta.

Ajayi A.A., Halushka P.V. (1995): Cardiovascular thrombogenicity of testosterone. 24th Annual Conference of Nigerian Cardiac Society, Ile-Ife, 1995. Abstract No.3, p.14.

Ajayi AA, Halushka PV. Testosterone increases platelet thromboxane A2 receptors and aggregation responses : implications for thrombotic cardiovascular diseases.

Association of Physicians of Nigeria National Conference, Lagos, March 1995.

Adewole A.D., Ikem R.T., Adigun A.Q., Akintomide A.O., Balogun M.O., Ajayi A.A.: A 3 year study of the impact of ACE inhibitors on the prognosis of congestive heart failure in Nigerians. Proceedings of 24th Annual Conference of Nigerian Cardiac Society, Ile-Ife, 1995.

Adigun A.Q., Akintomide A.O., Balogun M.O., Ajayi A.A.: An echocardiographic and clinical audit of rheumatic heart disease. 24th

28

Annual Conference of Nigerian Cardiac Society, Ile-Ife, 1995.

Afolabi M.A., Ajayi A.A., Balogun M.O., Akintomide A.O., Ajayi O.E.: Oral therapy with ACE inhibitor, Alpha 1 antagonist and Thiazide diuretic combination, normalizes BP in hypertensive crises. Proceedings of 24th Annual Conference of Nigerian Cardiac Society, Ile-Ife, 1995.

Ajayi A.A.: ‘ACE inhibition’: From molecular Pharmacology to man “State-of-the-art-lecture.” 24th Scientific Conference of Nigerian Cardiac Society, Ile-Ife, April 1995.

Adigun A.Q., Akintomide A.O., Balogun M.O., Ajayi A.A.: An echocardiographic and clinical audit of rheumatic heart disease. Abstract 1(1995). Proceedings of Nigerian Cardiac Society 24th Annual Conference Ile-Ife, P.13.

Afolabi M.A., Ajayi A.A., Balogun M.O., Akintomide A.O., Ajayi O.E.(1995): Oral therapy with ACE inhibitor, Alpha 1 blocker and thiazide diuretic combination normalizes BP in hypertensive crises. Proceedings of 24th Annual Conference of Nigerian Cardiac Society, Ile-Ife. Abstract 6, P 16.

Balogun M.O., Ikem R.T., Akintomide A.O., Ajayi A.A. (1995). Determinants of intra-hospital mortality in Nigerian patients with congestive heart failure. Proceedings of 24th Annual Conference of Nigerian Cardiac Society, Ile-Ife. Abstract 8, P 18.

Adewole A.D., Ikem R.T., Adigun A.Q., Akintomide A.O., Balogun M.O., Ajayi A.A.: A 3 year clinical review of the impact of ACE inhibitors on the prognosis of congestive heart failure in Nigerians. Proceedings of 24th Annual Conference of Nigerian Cardiac Society, Ile-Ife, 1995. Abstract 10, P.20.

Balogun M.O., Akintomide A.O., Ajayi O.E., Ajayi A.A. (1995): An Open Non-comparative study to examine the antihypertensive effect of a fixed dose of combination of Lisinopril (20mg) plus hydrochlorothiazide (12.5 mg) (Zestoretic) in patients with mild to moderate essential hypertension. 24th Annual Scientific Conference of Nigerian Cardiac Society, Ile-Ife, 1995. Abstract 12, P.20.

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Ajayi A.A., Babalola R.O. Oyelola O.O., Stein R.: Hypertensive-Diabetic Nigerian patients: Echocardiography, Treadmill exercise tolerance, Lipid profile and therapeutic studies. 2nd Nigerian Society of Hypertension meeting, Ibadan, Nigeria, 1995. Abst 8.

Ajayi AA, Afolabi MA, Balogun MO et al. Angiotensin converting enzyme inhibitor- thiazide diuretic- alpha-1 blocker combination normalizes blood pressure in hypertensive crises. 2nd Nigerian Society of Hypertension meeting, Ibadan, Nigeria 1995, Abstract 2.

Sofowora G., Ajayi A.A. Balogun M.O. et al: Concurrent Alpha 1 blockade and ACE inhibition in congestive heart failure. 20th A G M and Scientific Meeting, West African College of Physicians. Lagos , November 1995.

Ajayi A.A. “Hypertension in Nigerians”- An Update. Nigerian Medical Association/Pfizer plc, Akure, Ondo State, Nigeria, October 12, 1995.

Ajayi A.A. Balogun M.O., Sofowora G.G.: Concurrent Alpha 1 adrenergic blockade and ACE inhibition in the treatment of congestive heart failure. 4th International Symposium on heart failure, Jerusalem, Israel, 1996. Eur Jorunal of Heart Failure. Abstract No, 1736.

Rotimi O, Ajayi A.A., Odesanmi W.O.: Pathological basis of sudden cardiac death in Nigerians, Nigerian Cardiac Society Silver Jubilee scientific conference Lagos, Nigeria. 1996. Abstract 1.

Kolawole B.A., Ajayi A.A.: Prognostic indices for intrahospital mortality in Hypertensive Diabetic Nigerians. Proceedings to Silver Jubilee meeting for the Nigerian Cardiac Society 1996 Lagos Nigeria.

Adigun A.Q., Ajayi A.A. :ACE inhibition induced cough in Nigerians. Nigerian Cardiac Society Silver Jubilee scientific conference. 1996 Lagos, Nigeria P 24.

Sofowora G.G., Adigun A.Q., Ajayi A.T., Ajayi A.A.: Evidence of synergism between ACE-inhibitors and Alpha 1 Adrenergic blockade during forearm isometric exercise in normal man. Proceeding Nigerian Cardiac Society Lagos 1996, Nigeria.

Adebayo R.A., Sofowora G.G., Onayemi O., Ajayi A.A., Udoh S.J. Efficacy and Safety of niacin, predisolone and combination in chloroquine-induced pruritus in malaria fever: Comparison with antihistamines. Proceedings

30

of the West African College of Physicians (Nigeria Chapter) Conference, November 1997, Ile-Ife.

Ajayi A.A. Akintomide AO, Sofowora G, Adigun A.Q, Balogun M.O. Haastrup A.T. Concurrent Renin Angiotensin inhibition and Alpha 1 adrenergic blockade with diuresis as Rational therapy of cardiovascular disease. Proc. 5th Annual Scientific and General meeting Nigerian Society of Hypertension P12. Lagos 1997.

Ajayi AA, Balogun MO, Akintomide AO, Andy JJ, Chukwuani CM . A double –blind , placebo controlled , randomized parallel group study of the antihypertensive efficacy and safety of cilazapril, hydrochlorothiazide and their combination in Nigerians with mild-to moderate essential hypertension. Proceedings of the 5th annual conference of the Nigerian Hypertension Society , Lagos, 1997. P 12-13.

Adigun AQ, Ajayi AA. Angiotensin converting enzyme induced cough. Proceedings of the Annual West African College of Physicians (Nigeria Chapter) Ile-Ife, 1997.

Adebayo RA , Sofowora GG, Udoh SJ, Onayemi O, Ajayi AA. Efficacy and safety of Niacin , prednisolone , and combination in chloroquine-induced pruritus in malaria fever: comparison with anti-histamines. Proceedings of the West African College of Physicians

( Nigeria Chapter) conference, Ile-Ife, Nigeria, November, 1997.

Adigun AQ, Sofowora GG, Ajayi AA. Adjunctive sympathoplegic therapy in congestive heart failure: alpha or beta blockade ? Proceedings of the 27th

annual conference of the Nigerian Cardiac society. Ilorin , December 7-8. 1998, Abstract no 4.

Adigun AQ, Ajayi AA. Et al. Quantitative evaluation and correlates of cachexia in Nigerian patients with congestive heart failure. 27th Annual Scientific conference of the Nigerian Cardiac Society. Ilorin , December 7-8, 1998, abstract 2 .

Adigun AQ, Ishola DA, Akintomide AO, Ajayi AA. Trends in the prescription patterns of antihypertensive drugs in Nigerian patients with essential hypertension.Nigerian Society of Hypertension annual scientific conference, 2000, Lagos.

Ajayi AA, Adigun AQ, Sofowora GG. Adjunctive sympathoplegic therapy to

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ACE –inhibition in blacks with congestive heart failure : alpha or beta blockade ? Clinical Pharmacology & Therapeutics , 2001, 69 p 4. 102nd ASCPT conference Florida , USA.

Ajayi AA, Adigun AQ, Asiyanbola B. Cardiac autonomic function in Nigerians with congestive heart failure. RCMI international symposium on Health disparities. Puerto Rico. November, 2000.

Ajayi AA , Adigun AQ, Ajayi OE, Sofowora GG. Combined captopril –prazosin versus isosorbide dinitrate – hydralazine in acute left ventricular failure. A comparison of impact on cardiorespiratory function and survival. 27th annual conference of the Nigerian cardiac society. Ilorin, 1998, abstract no 3.

Kolawole BA, Ajayi AA. Prognostic Indices for in-hospital mortality of hypertensive-diabetic Nigerians. International Diabetes Federation Conference, 1998, Osaka , Japan.

Ajayi AA, Pamugo J, Hercule HC, Oyekan AO. Interactions between the renin-angiotensin system and the alpha-1 adrenergic system on systemic and renal hemodynamics in healthy and acute renal failure rats : role of nitric oxide. Experimental Biology meeting March 2001, Florida, abstract 202.7.

Hercule HC, Ajayi AA, Oyekan AO. Role of endothelin –1 in U46619 induced increase In renal medullary blood flow. Experimental biology meeting, March 2001, Florida.

Ajayi AA, Hercule HC, Hayes BE, Oyekan AO. Gender differences in the vascular and platelet reactivity toTXA2 mimetic and to endothelial nitric oxide system in Zucker fatty diabetic rats. Experimental Biology scientific conference, New Orleans, Louisiana , 2002, abstract 694.12

Ajayi AA, Adigun AQ, Ishola DA , Akintomide AO. Real world therapeutic efficacy of old and new antihypertensive drugs in Nigerians. International Society of Hypertension in Blacks, Orlando Florida, 2002, abstract no 2. J Natl Med Assoc 2002, 94, 278.

Mutembei L, Ogungbade O, Ajayi AA. Endothelin receptor subtype and TXA2 mimetic interactions in Zucker Diabetic rats : role of sex

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hormones ?Annual Biomedical and Pharmaceutical research conference , New Orleans, LA ,Nov 13, 2002.

Ajayi AA, Ogungbade O. Sex hormones and Endothelin-1- TXA2 in Zucker diabetic Rats . Experimental Biology meeting, 2003, San-Diego, California. Abstract 583. Invited Symposium-American Society of Pharmacology and Experimental Therapeutics

Ajayi AA, Newaz MA, Hercule HC, Bode CO, Oyekan AO,. Pausinystalia Yohimbie

extract has endothelin / nitric oxide actions. Experimental Biology conference 2003. San Diego California, 2003. Abstract 591.

Ajayi AA , Kolawole BA. Sickle cell trait is a risk factor for diabetic vascular complications in blacks. 2003 National Medical Association convention abstract. Philadelphia, PA.

Ajayi AA, Kolawole BA. A double blind comparison of naltrexone and promethazine in patients with an established history of severe chloroquine-induced pruritus n malaria fever. Clin Pharmacol Ther 2004 75 (2) p 25.

Ajayi AA, Halushka PV. Castration reduces human platelet TXA2 receptor density and aggregability . Clin Pharmacol Ther 2005 , 77 (2). p 43

Kolawole BA, Ajayi AA, Ikem RT. Sickle cell trait and gender influence diabetic complications in Africans. 2004, November 3-5. Endocrinology Society UK, 195TH Scientific meeting.

Ajayi AA, Fidelis P. Flutamide regulates microcirculation in female Zucker diabetic rats6th Diabetic Technology Society conference, Atlanta, November 2-6. 2006 .

76. Ajayi AA, Abiona TC, Ajayi OE. Does pre-existing or early onset valvular regurgitation accelerate hypertensive heart disease in blacks ? 62nd Annual Scientific Meeting of the High Blood Pressure Council of the American Heart Association. Atlanta, 2008, September 19. LB062.

77. is valvular regurgitation a risk factor for arrhythmogenicity in hypertensive heart disease and failure ? : Studies with Doppler echocardiography and 24 hour Holter EKG monitor. 51ST IsraelHeart

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Society Conference, Jerusalem, April 2012.

78.Valvular Regurgitation may increase risk of arrhythmias in hypertensive heart failure in blacks. 66th meeting of the High Blood Pressure Research Council Meeting of the American Heart Association. Abstract 309. Washington DC, September 19-22. Hypertension 2012. 60 : A326.

Other publications on or about me or my work. Guardian Nigeria Editorial of March 18, 1997 – Cure for Hypertension – Editorial written in recognition of my groups research work with synergistic combination of drugs including ACEI-Inhibitors and sympathoplegics to reduce mortality by 50% in black patients with congestive heart failure and acute pulmonary edema, and in hypertensive type -2 diabetic patient. Agence France Press – September 13, 1999- Report of the the discovery by my research of the involvement of opiate receptors and non –histaminergic mechanisms of the then enigmatic severe itching due to chloroquine .Circulation 1995, 91, 2694-98 “of muscle, mice, and men “ – Editorial on my research published in the journal Circulation. International Journal of Cardiology-2001 – Cachexia is a world wide problem –Editorial on my work on Cachexia. Journal of National Medical Association Book Review – 2002 – Review of my book “Diaspora Medicine”Several others in Nigerian News papers, Houston Punch, Chicago Inquirer, blogs etc

Adesuyi Adeyinka Leslie Ajayi BSc, MB, Ch.B., Ph.D., FWACP, FBPharmacolS, IOM.

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