curriculum vitae frederick arthur lenz emographic … · curriculum vitae _____ frederick arthur...

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CURRICULUM VITAE ______________ Frederick Arthur Lenz DEMOGRAPHIC INFORMATION Current Appointments:

A. Earl Walker Professor of Functional Neurosurgery School of Medicine, The Johns Hopkins University, Baltimore, MD. 2008- present. Professor of Neuroscience, School of Medicine. The Johns Hopkins University, Baltimore, MD. 2007- present.

Professor of Neurosurgery, School of Medicine. The Johns Hopkins University, Baltimore, MD. 1998 - present. Attending Neurosurgeon The Johns Hopkins Hospital, Baltimore, MD.

1988- present. - Chief- Epilepsy Surgery 1994 - 2015.

The Johns Hopkins Bayview Medical Center, Baltimore, MD. Attending Neurosurgeon 1988 - 2002 Part-time Attending Staff 2002 – 2015.

Personal Data:

Office Address:

Meyer Building 8-181 The Johns Hopkins Hospital 600 N. Wolfe Street Baltimore, MD 21287-7713 Tel: 410.955.2257 Fax: 443 287 8044

Laboratory Address Meyer Building 5-111 The Johns Hopkins Hospital 600 N. Wolfe Street Baltimore, MD 21287-7713 Tel: 410.955.7078

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Email Address: [email protected] (O)

Date of Birth: December 7, 1951

Place of Birth: Hamilton, Canada

Citizenship: Canadian by birth

Naturalized American December 15, 2000

Education:

1973 University of Toronto B.Sc.- Chemistry and Physics. Senior Project: ‘ Effect of acetylene structure on rates and products of addition of 4-chloro-benzene-sulphenyl chloride.

1977 University of Toronto M.D. 1981

1988

University of Toronto

University of Toronto

M.Sc. - Thesis: The Electromyographic Response to Displacement of Several Joints in the Squirrel Monkey Forelimb. Ph.D. - Thesis: Single Unit Analysis of the Ventral Nuclear Group of Human Thalamus.

2015 University of Oxford

Sabbatical on fMRI techniques with I Tracey at fMRIB, Sept to Dec 2015.

2015 University of Oxford. Training:

1977-78 Wellesley Hospital, Toronto Surgical Intern. 1979-83 University of Toronto Fellow – Neurosurgical

Research

Junior Resident

1978-79 Toronto General Hospital Cardiovascular Surgery Toronto Western Hospital Orthopaedic Surgery.

1983-84 Toronto General Hospital Neurosurgery Sunnybrook Medical Center,

Toronto Senior Resident

Neurosurgery

1984-85 St. Michael’s Hospital, Toronto Neuroradiology St. Michael’s Hospital, Toronto

Neurology

1985-86 Toronto Western Hospital Neurosurgery Toronto General Hospital

Neurosurgery

1986-87 Hospital for Sick Children, Toronto Neurosurgery Toronto General Hospital Neuropathology Toronto General Hospital Neurosurgery

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Clinical Fellow 1987-88 Toronto General Hospital Botterell Fellow Courses July 2002 University of Pittsburg Gamma Knife Course

Professional Experience:

1988- 1992

Assistant Professor of Neurosurgery, School of Medicine The Johns Hopkins University, Baltimore, MD.

1992-1998

Associate Professor of Neurosurgery, School of Medicine The Johns Hopkins University, Baltimore, MD.

1988-1994

Chief- Department of Neurosurgery Johns Hopkins Bayview Medical Center, Baltimore, MD.

1998- present

Professor of Neurosurgery and Neuroscience, School of Medicine The Johns Hopkins University, Baltimore, MD

2005- present 2008 – present

Clinical Associate, Neuro-engineering group of Biomedical Engineering, John Hopkins University, Baltimore, MD. A Earl Walker Professor of Functional Neurosurgery. John Hopkins, University.

RESEARCH ACTIVITIES.

Publications: Harzing Index 46 A.i. Journals (published/in press): 1. Schmid, G.A., Modro, A., Lenz, F.A., Garratt, D.G. and Yates, K. Effects of acetylene structure on rates and products of addition of 4-chloro-benzene-sulphenyl chloride. J. Org. Chem. 41: 2331-2336, 1976. 2. Lenz, F.A., Tatton, W.G. and Tasker, R.R. Electromyographic response to displacement of different forelimb joints in the squirrel monkey. J. Neurosci. 3: 783-794, 1983. 3. Lenz, F.A., Tatton, W.G. and Tasker, R.R. The effect of cortical lesions on the electromyographic response to joint displacement in the squirrel monkey forelimb. J. Neurosci. 3: 795-805, 1983. 4. Lenz, F.A., Tasker, R.R., Kwan, H.C., Murphy, J.T. and Nguyen-Huu, H.H. Techniques for the study of spike trains in the human central nervous system. Acta Neurochirg. Supp. 33: 57-61, 1984. 5. Lenz, F.A., Tasker, R.R., Kwan, H.C., Schnider, S., Kwong, R. and Murphy, J.T. Cross-correlation analysis of thalamic 'tremor cells' and electromyographic activity in patients with parkinsonian tremor. Appl. Neurophysiol. 48: 305-309, 1986. 6. Schnider, S.M., Kwong, R.H., Kwan, H.C. and Lenz, F.A. Detection of feedback in the central nervous system of parkinsonian patients. IEEE Transactions on Decision & Control 25(1): 291-294, 1986. 7. Lenz, F.A., Schnider, S. Tasker, R.R., Kwong, R., Kwan, H.C., Dostrovsky, J.O. and Murphy, J.T. The role of feedback in the tremor frequency activity of tremor cells in patients with parkinsonian tremor. Acta Neurochirg. Suppl. 39: 54-57, 1987. 8. Lenz, F.A., Tasker, R.R., Tatton, W.G. and Halliday, W. Long latency reflex activity in a

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primate MCA occlusion model of human spasticity. EEG Clin. Neurophysiol. 67: 238-246, 1987. 9. Tasker, R.R., Lenz, F.A., Yamashiro, Gorecki, J., Hirayama, T. and Dostrovsky, J.O. Microelectrode techniques in localization of stereotactic targets. Neurol. Res. 9: 105-112, 1987. 10. Lenz, F.A., Tasker, R.R., Dostrovsky, J.O., Kwan, H.C., Gorecki, J., Hirayama, T. and Murphy, J.T. Abnormal neuronal activity in the thalamus of a quadriplegic patient with central pain. Pain 31:225-236, 1987. 11. Lenz, F.A., Tasker, R.R., Kwan, H.C., Schnider, S., Kwong, R., Dostrovsky, J.O. and Murphy, J.T. Selection of the optimal target for the relief of parkinsonian tremor on the basis of spectral analysis of neuronal firing patterns. Appl. Neurophysiol. 50: 338-343, 1988. 12. Tasker, R.R., Dostrovsky, J.O., Lenz, F.A., Yamashiro, K. and Gorecki, J. Thalamic microelectrode recording and microstimulation in central and deafferentation pain. Appl. Neurophysiol. 50: 414-417, 1988. 13. Lenz, F.A., Tasker, R.R., Dostrovsky. J.O., Kwan, H.C., Gorecki, J., Hirayama, T. and Murphy, J.T. Human single unit activity and responses to stimulation in the presumed ventrocaudal nucleus of patients with central pain. Pain Research and Clinical Management 3:157-164, 1988. 14. Lenz, F.A., Dostrovsky, J.O., Kwan. H.C., Tasker, R.R., Yamashiro, K. and Murphy, J.T. Methods for microstimulation and recording of single units and evoked potentials in the human central nervous system. J. Neurosurg. 68: 630-634, 1988. 15. Lenz, F.A., Tasker, R.R., Kwan, H.C., Dostrovsky, J.O. and Murphy, J.T. Single unit analysis of the human thalamic ventral nuclear group: correlation of thalamic 'tremor cells' with the 3-6 Hz component of parkinsonian tremor. J. Neurosci. 8: 754-764, 1988. 16. Lenz, F.A., Tasker, R.R., Dostrovsky, J.O., Kwan, H.C., Yamashiro, K. and Murphy, J.T. Single unit analysis of the human ventral thalamic nuclear group: somatosensory responses. J. Neurophysiol. 59: 299-317, 1988. 17. Hirayama, T., Dostrovsky, J.O., Gorecki, J., Tasker, R.R. and Lenz, F.A. Recordings of abnormal activity in patients with deafferentation and central pain. Stereo. and Functional Neurosurgery 52: 120-126, 1989. 18. Gorecki, J., Hirayama, T. Dostrovsky, J.O., Tasker, R.R. and Lenz, F.A. Thalamic stimulation and recording in patients with deafferentation and central pain. Stereo and Functional Neurosurgery 52: 219-226, 1989. 19. Schnider, S.M., Kwong, R.H., Lenz, F.A. and Kwan, H.C.Detection of feedback in the human CNS by system identification techniques. Biological Cybernetics 60: 203-212, 1989. 20. Lenz, F.A., Kwan, H.C., Dostrovsky, J.O. and Tasker, R.R. Characteristics of bursts of action potential which occur in the sensory thalamus of patients with central pain. Brain Research 496: 357-360, 1989. 21. Lenz, F.A., Martin, R., Kwan, H.C., Tasker, R.R., Dostrovsky, J.O., and Delong, M.R. Thalamic single unit activity in patients with hemidystonia. Functional and Stereotactic Neurosurgery 54: 159-162, 1990. 22. Lenz, F.A., Neurophysiologic studies in patients with pain secondary to neural injury. Adv. Pain Res. Ther. 19:141-150, 1991. 23. Lenz, F.A., Kwan, H.C., Dostrovsky, J.O., Tasker, R.R., Murphy, J.T., Lenz, Y.E. Single unit analysis of the human ventral thalamic nuclear group: Activity correlated with movement. Brain 113: 1795-1821, 1990. 24. Lenz, F.A. Ascending modulation of thalamic function and pain: Experimental and clinical data. Advances in Pain Research and Therapy 20:177-196, 1991. 25. Lenz, F.A, Boivie,J., Casey,K.L., Jones,E.G. The ventral posterior nucleus of thalamus is involved in the generation of central pain syndromes. J. Am. Pain Society 1:42-51, 1992. 26. Lin, Y.C. and Lenz, F.A. Effective response evoked by microstimulation of thalamic nuclei in patients with tremor. Chinese Medical Journal 106:372-374, 1993. 27. Lenz, F.A., Vitek, J.R., DeLong, M.R. The role of Thalamus in Parkinsonian Tremor: Evidence from studies of patients and primate models. Stereotactic and Functional Neurosurgey 60:94-103,

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1993. 28. Lenz, F.A., Seike, M., Lin, Y.C., Richardson, R.T., Baker, F.H., C.J. Jaeger and Gracely, R.G. Thermal and pain sensations evoked by stimulation in the area of the human ventrocaudal nucleus. J. Neurophysiol. 70:200-213, 1993. 29. Lenz, F.A. Seike, M., Lin, Y.C., Baker, F.H., Rowland, L.H., Gracely, R.G. and Richardson, R.T., Neurons in the area of human thalamic nucleus ventralis caudalis (Vc) respond to painful heat stimuli. Brain Res. 623:235-240, 1993. 30. Dougherty, P.M. and Lenz,F.A. Plasticity of the nervous system following neural injury. Prog. Pain Res. Manag. 3:439-460, 1995. 31. Lenz, F.A., Kwan, H.C., Martin, R., Dostrovsky, J.O., Tasker, Murphy, J.T. and Lenz, Y.E. Single unit analysis of the human thalamic ventral nuclear group: tremor-related activity in functionally identified cells. Brain 117: 531-543, 1994. 32. F.A.Lenz, R.H.Gracely, E. Hope, F.H. Baker, L.H.Rowland, P.M.Dougherty, R.T.Richardson. The Sensation of Angina can be evoked by Stimulation of the Human Thalamus. Pain 59: 119-125, 1994. 33. Lenz, F.A., Kwan, H.C., Martin, R., Tasker, R.R., Richardson, R.T., Dostrovsky, J.O. Characteristics of somatotopic organization and spontaneous neuronal activity in the region of the human principal sensory nucleus in patients with spinal cord transection. J. Neurophysiol. 72: 1570-1587, 1994. 34. Lin, Y.C. and Lenz, F.A. Distribution and response evoked by microstimulation of thalamic nuclei in patients with dystonia and tremor. Chinese Medical Journal. 107:265-270, 1994. 35. Lenz, F.A., Gracely, R.H., Rowland, L.H., Dougherty, P.H. A population of cells in the human thalamic principal sensory nucleus respond to painful mechanical stimuli.' Neurosci. Litt. 180:46-50, 1994. 36. Lenz,F.A., Dougherty, P.M. Pain Processing in Human Ventrocaudal Nucleus of Thalamus. Adv. Pain Res. and Therapy 22:175-185, 1995. 37. Lenz, F.A., Normand, S., Kwan, H.C., Andrews, D., Tasker, R.R., Jones, M.W., Dostrovsky, J.O. and Lenz, Y.E. Statistical prediction of the optimal site for thalamotomy in parkinsonian tremor. Movement Disorders. 10:318-328, 1995. 38. Lenz, F.A., Gracely, R.H., Romanowski, A.J., Hope, E.J., Rowland, L.H., Dougherty, P.H. Stimulation of human somatosensory thalamus can reproduce both the affective and sensory aspects of previously experienced pain. Nature (Medicine) 1:910-913, 1995. 39. Dougherty, P.M., Li, Y.J., Lenz, F.A., Rowland,L.H. and Mittman, S.M. Evidence that excitatory amino acids mediate afferent input to the primate somatosensory thalamus. Brain Res. 278:267-273, 1996. 40. Yoon,R.S, Tsang,P.W., Lenz,F.A., Kwan,H.C. Characterization of cortical spreading depression by imaging of intrinsic optical signals. Neuroreport 7:2671-2674, 1997. 41. Dougherty,P.M., Li, Y-J., Lenz,F.A., L.H.Rowland, Mittman, S. Correlation of effects of general anesthetics on somatosensory neurons and cortical EEG power. J. neurophysiol. 77: 1375-1392, 1997. 42. Lenz, F.A., Gracely, R.H., Rowland, L.H., Leopold, D.A., Zirh, A.T., Dougherty, P.M. A human thalamic nucleus mediating taste and other sensations related to ingestive behavior. J. Neurophysiol. 77:3406-3409, 1997 43. Lenz, F.A., Gracely, R.H., Zirh, A.T., Romanoski, A.J., Staats, P., Dougherty, P.M. The sensory-limbic model suggests testable hypotheses about the learned component of the affective dimension of pain. Pain Forum 6:41-43, 1997. 44. Suarez, J.I. Verhagen Metman, L.,. Reich, S.G., Dougherty, P.M., Hallett, M. Lenz, F.A. Pallidotomy for Hemiballismus: Efficacy and Characteristics of Neuronal Activity. Ann. Neurol. 42:807-811, 1997. 45. Mandir,A.S., Rowland,L.H., Dougherty,P.M., Lenz,F.A. Microelectrode recording and stimulation techniques during stereotactic procedures in the thalamus and pallidum. Adv. Neurol.

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74:159-165, 1997. 46. Lenz, F.A., Gracely, R.H., Romanoski, A.J., Dougherty, P.M. The sensory-limbic model of pain memory: Connections from thalamus to the limbic system mediate the learned component of the affective dimension of pain. Pain Forum 6:22-30, 1998. 47. Hua, S., Lenz, F.A., Zirh, T.A., Reich, S.G., Dougherty, P.M. thalamic activity correlated with essential tremor. J. Neurol. Neurosurg. Psych. 64:273-276, 1998. 48. Zirh, T.A., Lenz, F.A.,Reich, S.G., Dougherty, P.M. Patterns of bursting occurring in thalamic cells during Parkinsonian Tremor. Neuroscience 83, 107-121,1998. 49. Hua,S., Reich, S.G., Zirh, T.A. Perry, V.L., Dougherty, P.M., Lenz, F.A. Role of the Thalamus and Basal Ganglia in Parkinsonian Tremor. Movement Disorders 13(suppl. 3), 40-43, 1998. 50. Lenz, F.A., Dougherty, P.M. The new version of the thalamic disinhibition hypothesis may explain clinical features that occur in some patients with central pain. Pain Forum 7:20-23, 1998. 51. van der Munckhof, P., Lenz, F.A., Chase, T.N., Verhagen Metman, L. Square wave action dystonia in Parkinson’s disease. Movement Disorders 13:354-356, 1998. 52. Hillis, A.E., Lenz, F.A., Zirh, T.A., Eckel, T., Dougherty, P.M., Jackson, K. Hemispatial somatosensory and motor extinction after thalamic lesions. Neurocase. 4:21-34, 1998. 53. Lenz, F.A., Zirh, A., Garonzik, I.M., Richardson, R.T., Rowland, Dougherty, P.M. Characteristics of Spontaneous Neuronal Activity in the region of the Human Principal Sensory Nucleus of thalamus in Patients with Amputations. Neurosci. 86:1065-1081,1998. 54. Lenz, F.A., Rios, M., Zirh, T.A., Chau, D., Krauss, G., Lesser, R.P. Painful Stimuli Evoke Potentials Recorded over the Human Anterior Cingulate Gyrus. J. neurophysiol. 79:2231-2234, 1998. 55. Spatz, M., Kawai, N., Bembry, J., Lenz, F.A. and McCarron, R.M. Human Brain Capillary Endothelium: Modulation of K Efflux and K and Ca uptake by endothelium. Neurochemical Research 35:1135-1132, 1998. 56. Lenz, F.A., Dougherty,P.M. Neurons in the Human Thalamic Principal Somatosensory Nucleus (Ventralis Caudalis - Vc) Respond to Innocuous Cool and Mechanical Stimuli. J. neurophysiol. 79:2227-2231, 1998. 57. Oppenheimer, S.M., Kulshreshtha, N., Lenz, F.A., Rowland, L.H., Dougherty, P.M. Distribution of Cardiovascular related sites within the human thalamus. Clin. Autonomic Res. 8:173-179, 1998. 58. Dougherty,P.M., Mittman,S., Lenz,F.A. Facilitation of responses to AMPA but not kainate by cyclothiazide in primate somatosensory nucleus. Neurosci. Litt. 246:17-20, 1998. 59. Dougherty,P.M., Willis,W.D., Lenz,F.A. Transient inhibition of responses to thermal stimuli in monkey spinal sensory tract cells following intradermal injection of capsaicin. Pain 77: 129-136, 1998. 60. Lenz, F.A., Suarez, J.I., Verhagen-Metman, L., Reich, S.G., Karp, B.I., Hallett, M., Rowland, L.H., Dougherty, P.M. Pallidal activity during dystonia: somatosensory reorganization and activity dependent changes in spontaneous activity. J. Neurol. Neurosurg. Psych. 65: 767-770, 1998. 61. Lenz, F.A., Gracely, R.H., Baker, F.H., Richardson, R.T. and Dougherty, P.M., Reorganization of sensory modalities evoked by microstimulation in region of the thalamic principal sensory nucleus in patients with pain due to the nervous system injury. J. Comp. Neurol. 399:125-138, 1998. 62. Lenz,F.A., Rios, M., Chau, D., Krauss, G., Lessor, R.P. Painful stimuli evoke potentials recorded from the human parasylvian cortex. J. neurophysiol. 80: 2077-2088, 1998. 63. Zirh, T.A., Reich, S.G., Perry, V. and Lenz, F.A. Thalamic single unit and electromyographic activities in patients with dystonia. Adv. Neurol. 78:27-32, 1998. 64. Chen,Y., McCarron, M.C., Bembry, J., Ruetzler, C., Azzam, N., Lenz, F.A., Spatz, M. Nitric oxide modulates ET-1-induced Ca2+ mobilization and cytoskeletal F-Actin filaments in human cerebromicrovascular endothelial cells. J. Cerebral Bloodflow and Metabolism. 19:133-138, 1998. 65. Perry, V.L., Lenz, F.A. Ablative Surgery for Treatment of Movement Disorders: Thalamotomy for Parkinson’s disease. Neurosurgical Clinics of North America. 9:317-324, 1998. 66. Skolasky, R.L., Dal Pan, G.J., Olivi, A., Lenz, F.A., Abrams R.A., McArthur, J.C. HIV-

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associated primary CNS lymorbidity and the utility of brain biopsy. J.Neurol. Sci. 63:32-38, 1999. 67. Zirh, T.A., Reich, S.G., Dougherty, P.M., Lenz, F.A. Stereotactic Thalamotomy in the Treatment of Essential Tremor: Re-assessment including a Blinded Measure of Outcome. J. Neurol. Neurosurg. Psych. 66:772-775, 1999. 68. Lee, J., Dougherty P.M., Antezana, D., Lenz, F.A. Responses of neurons in the region of human thalamic principal somatic sensory nucleus to mechanical and thermal stimuli graded into the painful range. J Comp Neurol 410(4): 541-55, 1999. 69. Treede, R.D., Vogel, H., Rios, M., Krauss, G., Lesser, R.P., Lenz, F.A. Pain-related evoked potentials from parasylvian cortex in humans. Electroencephalogr Clin Neurophysiol (Suppl.) 49: 250-5, 1999. 70. Vitek, J.L., Lozano, A., Lenz, F.A. Stereotactic Ablative and Stimulation Procedures for Treatment of Movement Disorders. Neurosurgical Quarterly 9:103-119, 1999. 71. Greenspan, J.D., Lee, R.R., Lenz, F.A. Pain threshold elevations associated with lesions of parasylvian cerebral cortex. Pain 81273-282, 1999. 72. M.Rios, R.D.Treede, J-I. Lee, F.A.Lenz Evoked Potentials Recorded over the Human Anterior Cingulate Gyrus and Parasylvian cortex in Response to Painful Stimuli. Current review of pain 3: 256-264, 1999. 73. A.W. Lemstra, L.Verhagen Metman, P.M.Dougherty, J.I.Lee, F.A.Lenz. Tremor-frequency (3-6 Hz) activity in arm sensorimotor portion of the globus pallidus in patients with Parkinson’s disease. Neurosci. Lett. 267: 129-132, 1999. 74. Spatz,M., Yamamoto, T., Yamamoto,H., Brenner,M., Lenz,F.A., and McCarron, R. NO-mediated modification of endothelin receptor properties. Neurochemical Research 23:1125-1132, 1999. 75. Dougherty, P.M., Schwartz, A., and Lenz, F.A. Responses of primate spinomesencepthalic tract cells in intradermal capsaicin. Neuroscience 90: 1377-1392, 1999. 76. Lenz,F.A., Jaeger, C.J., Seike, M., Lin,Y.C., Reich, S.G., DeLong, M.R., Vitek,J.R. Single neuron analysis of the motor thalamus in patients with dystonia. J. Neurophysiol. 82: 2372-2392, 1999. 77. Giangaspero, F., Guiducci, A., Lenz, F.A., Mastronardi, L., Burger, P.C. Meningioma with meningioangiomatosis: a condition mimicking invasive meningiomas in children and young adults. Am J Surg Path 23:872-875, 1999.

81. Lenz, F.A., Byl, N.N. Reorganization in the Cutaneous Core of the Human Thalamic Principal Somatic sensory Nucleus (Ventral caudal - Vc) in patients with dystonia. J. Neurophysiol. 82:3204-3212, 1999.

82. Hallett, M., Litvan, I., and the members of the Task Force on Surgery for Parkinson’s disease of the American Academy of Neurology Therapeutic and Technology Assessment Committee. Evaluation of Surgery for Parkinson’s disease. Neurology 53:1910-1921, 1999.

83. Chen,Y., McCaron, R.M., Azzam, N., Ruetzler, C., Lenz, F.A., Spatz, M. Endothelin-1 and Nitric Oxide affect human microvascular endothelial responses and signal transduction. Acta Neurochirgica, Suppl. 76: 131-135, 2000.

84. Ohara,Y., McCarron, R.M., Hoffman,T.J., Sugano,H., Bemby,J., Lenz, F.A., Spatz,M.. Adreneric mediation of TNF-alpha stimulated ICAM-1 expression on human brain microvascular endothelial cells. Acta Neurochirgica. Suppl. 76: 117-120, 2000.

85. Muthuswamy, J., Tran, R., Rangarajan, R., Lenz, F.A., Hanley,D.F., Thakor,N.V. Somatosensory stimulus entrains spindle oscillations in the thalamic VPL nucleus in barbiturate anesthetized rats. Neurosci Lett. 262: 191-194, 1999.

86. Boatman, D., Gordon, B., Hart, J., Selnes, O., Miglioretti, D., Lenz, F.A. Transcortical sensory aphasia: Revisited and revised. Brain 123:1634-1641, 2000.

87. Ralston, D.D., Dougherty, P.M., Lenz, F.A., Weng, H-R., Vierck, C.J., Ralston, H.J. Plasticity of the inhibitory circuitry and neuronal responses in the primate somatosensory thalamus following lesions of the dorsal column and spinothalamic pathways. Prog pain research manag. 16: 427-434, 2000.

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88. Lenz, F.A., Rios, M., Lee, J-I., Treede, R.D., Boatman, D., Port, J., Krauss, G. Pain and auditory-evoked potentials have different generators than the auditory P3 potential in temporal-parasylvian cortex. Neuroscience Letters 279:153-156, 2000.

89. Hallett, M., Litvan, I., and the members of the Task Force on Surgery for Parkinson’s disease of the American Academy of Neurology Therapeutic and Technology Assessment Committee. Scientific Position Paper of the Movement Disorder Society: Evaluation of Surgery for Parkinson’s disease. Movement Disorders 15:436-438, 2000.

90. Hua, S.E., Garonzik, I., Lee, J-I., Lenz, F.A. Microelectrode studies of normal organization and plasticity of human somatosensory thalamus. J Clin. Neurophysiol.: 17:559-274, 2000.

91. Treede, R.D., Apkarian, A.V., Bromm, B. Greenspan, J.D., Lenz, F.A. Cortical representation of pain: functional characterization of nociceptive areas near the lateral sulcus. Pain 87:113-120, 2000.

92. Boatman, D, Alidoost, M, Bergey, G, Gordon, B, Crone, N, Lenz, FA. Right hand language dominance in a right handed patient with late-onset seizures. Epilepsy and Behavior 1:281- 286, 2000.

93. Lenz,F.A., Lee,J-I., Garonzik, I.M., Rowland, L.H., Dougherty, P.M. Hua,S.E. Plasticity of pain-related neuronal activity in human thalamus. Progress in Brain Research. 129:259-273, 2000.

94. Weng, H.R., Lee, J-I, Lenz, F.A., Schwartz, A., Vierck, C., Rowland, L., Dougherty, P.M. Functional plasticity of the primate somatosensory thalamus following chronic lesion of the ventral lateral spinal cord. Neurosci. 101:393-401,2000.

95. Chen, Y., R.MacCarron, Ohara, Y., Bembry,J., Azzam,N., Lenz, F.A., Shohami, E., Mechoulam, R., Spatz, M., Human Brain Capillary Endothelium; 2-Arachidonoglycerol interacts with Endothelin. Circ Res. 87:323-327, 2000.

96. I. Garonzik, E.Samdani, S.Ohara, F. A. Lenz. Deep brain stimulation for the control of pain. Epilepsy and Behavior 2: S55-60, 2001.

97. Moriarity, J.L, Krauss, G.L., Boatman, D., Storm, P., Lenz, F.A. Memories can be evoked by electrical stimulation of lateral temporal cortex after hippocampal resection. Journal of Neurol Neurosurg Psych 71:549-551, 2001.

98. I.M.Garonzik, S.E.Hua, S. Ohara, F.A. Lenz. Intraoperative microelectrode recording and semi-microrecording during the physiologic localization of thalamic nucleus ventral intermediate. Movement Disorders – 17:S135-144, 2002.

99. P. Krack, J. Dostrovsky, I. Ilinsky, K. Kultas-Ilinsky, F. Lenz, A. Lozano, J. Vitek Surgery of the motor thalamus: problems with the present nomenclatures. Movement Disorders, - 17:S2-8, 2002.

100. S. Ohara, F.A. Lenz ,Reorganization of somatic sensory function in the human thalamus after ischemic stroke. Annals of Neurology, 50:800-803, 2002.

101. F. A. Lenz, C. J. Jaeger, M. S. Seike, Y. C. Lin+, S. G. Reich., Single Neuron Analysis of Human Thalamus in Patients with Intention Tremor and Cerebellar Signs. J. Neurophysiol. 87: 2084-2094, 2002.

102. Weng, H-R, Lenz, F.A., Vierck, C, Dougherty, P.M., Physiological Changes in Primate Somatosensory Thalamus Induced by Deafferentation are Specific to Spinal Funiculi that are Sectioned and Time after the Injury. Neuroscience 116:1149-1160, 2003.

103. McCarron, R.M., Ohara,Y., Hoffman,T.J., Sugano,H., Bemby,J., Lenz, F.A., Spatz,M. Signal Transduction pathway involved in ET-1 and NO mediated interactions in human brain capillary endothelial cell responses. Am J Physiology – Cell Physiology. 284:C243-C249, 2003.

104. H. Vogel, J. Port, F.A. Lenz, M. Solaiyappan, G. Krauss, R-D Treede Dipole source analysis of laser evoked potentials recorded subdurally from parasylvian cortex in humans. J. Neurophysiol. 89:3051-3060, 2003.

105. Ohara S, Lenz FA. Medial lateral extent of thermal and pain sensations evoked by microstimulation in human thalamus. J. neurophysiol. 90:2367-2377, 2003.

106. Weiss, N., North, R.B., Ohara S, Lenz, F.A. Attenuation of Cerebellar Tremor with Intrathecal Baclofen Pump: the Role of Gabaergic Pathways in Cerebellar Intention Tremor. J Neurosurg. 99:

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768–771, 2003.

107. S. Ohara, N. Weiss, F. A. Lenz, Threshold microstimulation (TMIS) in the region of the human thalamic principal somatic sensory nucleus (Ventral Caudal - Vc) evokes sensations like those of mechanical stimulation and movement. J. neurophysiol. 91(2):736-745, 2003.

108. Ohara S, Crone NE, Weiss N, Treede RD and Lenz FA. Cutaneous painful laser stimuli evoke responses recorded directly from primary somatosensory cortex in awake humans. J. neurophysiol. 91: 2734-2746, 2004.

109. Greenspan JD, Ohara S, Sarlani E, Lenz FA. Allodynia in Patients with Post-Stroke Central Pain (CPSP) studied by Statistical Quantitative Sensory Testing within Individuals. Pain. 109:357-366, 2004.

110. Ohara S, Crone NE, Weiss N, Lenz FA. Attention to a painful cutaneous laser stimulus modulates electrocorticographic event-related desynchronization in humans. Clin Neurophysio. 115:1641-1652, 2004.

111. Ohara S, Crone NE, Weiss N, Treede RD, Lenz FA. Attention to pain is mediated through a multiple cortical sites in man. Experimental Brain Research 156:513-315, 2004.

112. F. A. Lenz, S. H. Patel, R.H. Gracely, P.M. Dougherty, S. Ohara Pain encoding in the human forebrain: Binary and analog channels. J Neurosci. 24: 6540-6544, 2004. DOI:10.1523/JNEUROSCI.1630-04.2004

113. Golech, S., R.MacCarron, Chen, Y., Bembry,J., Lenz, F.A., Mechoulam R., Shohami E., Spatz M. Human brain endothelium: Coexpression and function of vanilloid and endocannabinoid receptors. Molecular Br. Res. 132:87-92, 2004.

114. Ohara S, Crone NE, Weiss N, Treede RD, Lenz FA. Amplitudes of laser evoked potential recorded from primary somatosensory, parasylvian and medial frontal cortex are graded with stimulus intensity – Pain: 110:318-328, 2004.

115. Sinha, SR, Crone, N, Fotta, R, Lenz, FA, Boatman, D. Transient contralateral hearing loss induced by cortical stimulation of the dominant hemisphere. Neurology. 64: 383-5, 2005. PM:15668450. DOI 10.1212/01.WNL.0000149524.11371.B1.

116. S. E. Hua, F.A.Lenz, Posture-Related Oscillations in Human Cerebellar Thalamus in Essential Tremor Are Enabled by Voluntary Motor Circuits. J. Neurophysiol. – 93:117-127, 2005. PM:15317839. doi: 10.1152/jn.00527.2004.

117. Lee J-I, Ohara S, Dougherty,P.M. Lenz,F.A. Pain and temperature encoding in the human thalamic somatic sensory nucleus (Ventral caudal - Vc): Inhibition-related bursting evoked by somatic stimuli. J. Neurophysiol. 94: 1676-1687, 2006 – E-press, 6/1/05. PM:15901758. doi: 10.1152/jn.00343.2005.

118. Weiss N., Lawson, H.C., Anderson, S., Greenspan. J.D., Lenz FA. Neuronal activity recorded along the human forebrain ‘pain pathway’. Thalamus and related systems. – 3:71-86, 2005.

119. A. Sinai, C. Bowers, C.M. Crainiceanu, D. Boatman, B. Gordon, R.P. Lesser, F.A. Lenz, N.E. Crone. Electrocorticographic high gamma activity during naming vs. electrical cortical stimulation. Brain 128:1556-1570, 2005. PM:15817517. doi: 10.1093/brain/awh491.

120. S. Ohara, F.A. Lenz, Y-D. Zhou. Modulation of somatosensory event-related potential components in a tactile–visual cross-modal task. Neuroscience, 138: 1387-139, 2006. PM:16442738. doi:10.1016/j.neuroscience.2005.12.005.

121. S. Patel, S. Ohara, Dougherty,P.M., R.H. Gracely, Lenz,F.A. Psychophysical elements of place- and modality-specificity in the thalamic somatic sensory nucleus (ventral caudal - Vc) in awake humans. J. Neurophys. 95: 646-659, 2006. PMID: 16192330. doi: 10.1152/jn.00756.2005.

122. H Chen, SE Hua, FA Lenz, R Shadmehr. Effect of Disruption of Human Cerebellar Thalamus on Motor Learning. Cerebral Cortex 16: 1462-1473, 2006. PMID: 16357337. PMCID: PMC1560096. doi: 10.1093/cercor/bhj087.

123. Ohara, F. A. Lenz, Y.-D. Zhou. Sequential Neural Processes of Tactile-visual crossmodal

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working memory. Neuroscience. 139:299-309, 2006. PMID: 16442738. doi:10.1016/j.neuroscience.2005.12.005.

124. G Rasouli, M. Rasouli, FA Lenz, Donald S. Borrett, HC Kwan. Fractal characteristics of human parkinsonian neuronal spike trains. Neuroscience. 139:1153-1159, 2006. - PM:16515843. doi:10.1016/j.neuroscience.2006.01.012.

125. Ohara S, Crone NE, Weiss N, Lenz FA. Analysis of synchrony demonstrates ‘pain networks’ defined by rapidly-switching, task-specific, functional connectivity between pain-related cortical structures. Pain. 123:444-53, 2006. PMID: 16563627. doi:10.1016/j.pain.2006.02.012.

126. DF Boatman, RP Lesser, NE Crone, G. Krauss, FA Lenz, DL Miglioretti. Speech Recognition Impairments in Patients with Intractable Right Temporal Lobe Epilepsy. Epilepsia, 47(8):1397-401, 2006. PMID: 16922887. DOI: 10.1111/j.1528-1167.2006.00562.x. July 6, 2006

127. R.J. Elble, and conference speakers. Report from a US Conference on Essential Tremor. Movement Dis., 21: 2052-2061, 2006.

128. S. Ohara, A. Taghva, A., Kim, J.H., Lenz,F.A. Spontaneous low threshold spike (LTS) bursting in awake humans is different in different lateral thalamic nuclei. Exp. Brain Res. 180: 281-288, 2007. PM:17256161. Jan 26, 2007.

129. J.I. Lee, L. Verhagen Metman, P. Chen, P.M. Dougherty, J.H. Kim, F.A. Lenz. Neuronal activity in the sensorimotor area of the globus pallidus internus in Parkinsonian patients: single cell recordings during ‘off, ‘on’, and ‘on-with-dyskinesia’. J. Neurophysiol. 97: 2627-2641, 2007. PM:17215512. doi:10.1152/jn.00443.2006. Jan 2007.

130. JH Kim, JD Greenspan, RC Coghill, S Ohara, FA Lenz. Lesions limited to the human thalamic principal somatosensory nucleus (ventral caudal) are associated with loss of cold sensation and central pain. J.Neurosci 27:4995-5005, 2007. PMID: 17475808. DOI:10.1523/JNEUROSCI.0716-07.2007. (Featured article on Neurobiology of Disease).

131. Z Chen, S Ohara, J Cao, FB Vialatte, FA Lenz, A Cichocki. Statistical modeling and analysis of laser-evoked potentials of electrocorticogram recordings from awake humans. Comput Intell and Neurosci. Vol 2007. 2007: 10479, 24 pages. PMID: 18369410. PMCID: PMC2271124. doi: 10.1155/2007/10479.

132. Kleinman, JT, Sepkuty JP, Hillis AE, Lenz FA, Heidler-Gary J, Gingis L, Crone N. Spatial neglect during electrocortical stimulation mapping in the right hemisphere. Epilepsia. Epub July 21 2007, 23: 2365-2368, 2007. PMID: 17645542. doi: 10.1111/j.1528-1167.2007.01196.x.

133. AG Shaikh, HA Jinnah, RM Tripp, S Ramat, LM Optican, FA Lenz, DS Zee. Irregularity distinguishes limb tremor in cervical dystonia from essential tremor. J. Neurol. Neurosurg. Psychiatry. 19:187-189, 2007. JNNP PMID: 17872981. PMCID: PMC2737356. doi:10.1136/jnnp.2007.131110. published online 14 Sep 2007.

134. Ku Y, Ohara S, Wang L, Lenz FA, Hsiao SS, Bodner M, Hong B, Zhou YD. Prefrontal cortex and somatosensory cortex in tactile crossmodal association: an independent component analysis of ERP recordings. PLsO ONE, 2007 Aug 22;2(1):e771. PMID: 17712419. PMCID: PMC194211. doi: 10.1371/journal.pone.0000771.

135. Ohara S, Crone N, Weiss N, Kim, JH, Lenz FA. Analysis of synchrony demonstrates that the presence of ‘pain networks’ prior to a noxious stimulus can enable the perception of pain in response to that stimulus. Exp Brain Res. 185: 353-358, 2008. PMID: 18231782. DOI: 10.1007/s00221-008-1284-1.

136. JD Greenspan, RC Coghill, I Gilron, E Sarlani, D Veldhuijzen, and FA Lenz. Quantitative somatic sensory testing and functional imaging of the response to painful stimuli before and after cingulotomy for psychiatric disease. European J of Pain, 12:990-999, 2008. PMID: 18328752. doi:10.1016/ejpain_2008.01.007.

137. Ohara S, Wang L, Ku Y, Lenz FA, Hsiao SS, B.Hong, Zhou YD. Neural activities of tactile cross-modal working memory in human: An event-related potential study. Neuroscience 152:692-702, 2008. PMID: 18304742. DOI 10.1016/.neuroscience.200712.043.



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138. WS Anderson, HC Lawson, AJ Belzberg, FA Lenz. Selective denervation of the levator scapulae muscle: an amendment to the Bertrand procedure for the treatment of spasmodic torticollis. J Neurosurg. 108: 757-763, 2008. PMID: 18377256. DOI: 10.3171/JNS/2008/108/4/0757.

139. Greenspan JD. Ohara S. Franaszczuk P Veldhuijzen DS Lenz FA. Cold stimuli evoke potentials which can be recorded directly from parasylvian cortex in humans. J Neurophys. 100: 2282-2286, 2008. PMID: 18579655. PMCID: PMC2576208. doi:10.1152/jn.90564.2008. ePub ahead of print. (June 25, 2008).

140. Weiss N, Ohara S, Johnson KO, Lenz FA. The human thalamic somatic sensory nucleus [ventral caudal (Vc)] shows neuronal mechanoreceptor-like responses to optimal stimuli for peripheral mechanoreceptors. J Neurophysiol 101: 1033–1042, 2009. First published November 12, 2008. PMID: 19004995. PMCID: PMC2657072. doi:10.1152/jn.90990.2008. November 12 2008.

141. J.H. Kim, S. Ohara, F.A., Lenz. Mental arithmetic leads to multiple discrete changes from baseline in the firing patterns of human thalamic neurons. J Neurophysiol 101: 2107–2119, 2009. First published February 4, 2009; PMID: 19193769. PMCID: PMC2695644. doi:10.1152/jn.91087.2008.

142. Kobayashi K, Winberry,J, Liu,CC, Treede,RD, Lenz,FA. A painful cutaneous laser stimulus evokes responses from single neurons in the human thalamic principal somatic sensory nucleus ventral caudal (Vc). J Neurophysiol. 101: 2210-2217, 2009; PMID: 19925853. PMCID: PMC2815048. doi:10.1152/jn.91347.2008. (May 2009).

143. Veldhuijzen DS, Greenspan JD, J.H.Kim JH, Lenz FA. Altered pain and thermal sensation in subjects with isolated parietal and insular cortical lesions. European Journal of Pain. 14: e535-e1 – 535-e1I, 2010. PMID: 19939715. PMCID: PMC2872197. doi:10.1016/ejpain_2008.01.007. (Nov 21, 2009).

144. U Baumgärtner, H Vogel, S Ohara, RD Treede, F Lenz. The P22 median nerve SEP component: precentral or postcentral origin? Dipole source analysis from subdural grid recordings. Klin Neurophysiol 2010; 41 - ID122. DOI: 10.1055/s-0030-1250951

145. C.C. Liu, S. Ohara, P. Franaszczuk, N. Zagzoog, M. Gallagher, F.A.Lenz. Painful stimuli evoke potentials recorded from the medial temporal lobe in humans. Neuroscience, 165:1402-1411, 2010. PMID: 19985253. PMCID: PMC2815048. doi:10.1016/j.neuroscience.2009.11.026.

146. M. Rasouli, G. Rasouli, F.A. Lenz, D.S. Borrett, L. Verhagen, and H.C. Kwan. Chaos Game Representation of Human Pallidal Spike Trains. J Biological Physics. 36: 197-205, 2010. PMID: 19688266. PMCID: PMC2825310. DOI: 10.1007/s10867-009-9172-x.

147. U Baumgärtner, H Vogel, S Ohara, R-D Treede, FA Lenz. Dipole source analyses of early median nerve SEP components obtained from subdural grid recordings. J Neurophysiol. 104: 3029-3041, 2010. PMID: 20861430. PMCID: PMC3007666. doi: 10.1152/jn.00116.2010. (9/21/10).

148. CC Liu, DS Veldhuijzen, S Ohara, J Winberry, JD Greenspan, and FA Lenz. Spatial attention to thermal pain stimuli in subjects with visual spatial hemi-neglect: extinction, mislocalization and misidentification of stimulus sub-modality. Pain. 152: 498-506, 2011. PMID:21111534. DOI: 10.1016/j.pain.2010.11.011. (10/14/10).

149. K. Kobayashi, AE Lang, Hallett M, Lenz FA. Thalamic Neuron Activity in Psychogenic Dystonia compared with Organic Dystonia. Movement Disorders. 26: 1348-1352, 2011. epub as of 2011 Apr 15. PMID: 21500279, doi: 10.1002/mds.23565.

150. Anderson WS, Weiss N, Lawson HC, Ohara S, Rowland L, Lenz FA. Demonstration of Motor Imagery- and Phantom-Movement Related Neuronal Activity in Human Thalamus. Neuroreport 22: 88-94, 2010. PMID:21150804. PMCID: PMC3071423. DOI: 10.1097/WNR.0b013e328342c98a. (11/18/10).

151. Liu CC, Ohara S, Franaszczuk PJ, Lenz FA. Attention to painful cutaneous laser stimuli evokes directed functional connectivity between activity recorded directly from human pain-related cortical structures. Pain. 152: 664-675, 2011. PMID:21255929. PMCID: PMC3043083. doi:10.1016/j.pain.2010.12.016. (12/12/10).

152. Liu CC, Shi CQ, Franaszczuk PJ, Crone NE,, Schretlen D, Ohara S, Lenz FA. Painful laser

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stimuli induce directed functional interactions within and between the human amygdala and hippocampus. Neuroscience. 178: 208-217, 2011. PMID: 21256929. PMCID: PMC3048957. doi: 10.1016/j.neuroscience.2011.01.029 (1/11/11).

153. Baumgärtner, H Vogel, S Ohara, R-D Treede, FA Lenz. Dipole source analyses of laser evoked potentials (LEP) obtained from subdural grid recordings from primary somatic sensory cortex. J Neurophysiol. 106: 722-730, 2011. PMID: 21593389. PMCID: PMC3007666. doi:10.1152/jn.00135.2011. ePUB 8/11.

154. C.C.Liu, N.E.Crone, P.J. Franaszczuk, D. Cheng, D.S. Schretlen, F.A.Lenz, Fear conditioning is associated with dynamic directed functional interactions between and within the human amygdala, hippocampus and frontal lobe. Neuroscience 189: 359-369, 2011. PMID: 21664438. PMCID: PMC3048957. DOI: 10.1016/j.neuroscience.2011.05.067. NIHMSID 307888, Publ.ID: NSC13004. Pub 8/12/2011. ePub June 12, 2011.

155. CC Liu, S Ohara, P Franaszczuk, N Crone, FA Lenz. Attention to painful cutaneous laser stimuli evokes directed functional interactions between human sensory and modulatory pain-related cortical areas. Pain. (Dec. 2011) 152: 2781-2791. PMID: 22033363, PMCID: PMC3043083. doi:10.1016/j.pain.2011.09.002.

156. Liu, C.C., P. Franaszczuk, N. E. Crone, C. Jouny, Lenz,F.A. Studies of Properties of ‘Pain Networks’ as predictors of Targets of Stimulation for Treatment of Pain. Front. Integr. Neurosci. 5:80, 2011. PMID:22164137. PMCID: PMC3230069. doi: 10.3389/fnint.2011.00080. Published online 12/5/11.

157. L. Wang, X. Li, S. Hsiao, M. Bodner, F.A. Lenz, Y.D Zhou. Persistent neuronal firing in primary somatosensory cortex in the absence of working memory of trial-specific features of the sample stimuli in a haptic working memory task. J. Cogn Neurosci. n24: 664-67620, 2011. PMID: DOI: 22098263. F10.1162/jocn_a_00169, Epub 2011 Nov 18.

158. T.J.Bradberry, L.Verhagen Metman, Contreras-Vidal, P. van der Munckhof. L.A.Hosey, J.L.Thompson, G.M.Schultz, F.A.Lenz, R. Pahwa, K.E.Lyons, A.R.Braun. Common and unique responses to dopamine agonist therapy and deep brain stimulation in Parkinson’s disease: an H(2)(15)O PET study. Brain stimulation 5: 605-615, 2011.

159. T. Okada, K Teranishi, Y Chen, T Tomori, A Strasser, FA Lenz, RM McCarron, M Spatz. Reversal of post-ischemic hypoperfusion by Tempol: Endothelial signal Transduction Mechanism.

Neurochemical research. 37(4) 680-688. 2012. PMID:22139482. DOI 10.1007/s11064-011-0595 y.

160. L. Wang, X. Li, S. Hsiao, M. Bodner, F.A. Lenz, Y.D. Zhou. Behavioral Choice-related Neuronal Activity in Monkey Primary Somatosensory Cortex in a Haptic Delay Task. J. Cogn Neurosci. 24: 1634-1644, 2012. PMID: 22452554, DOI: 10.1162/jocn_a_00235, Epub 2012 Mar.

161. M.C.Cervenka, P.J. Franaszczuk; N.E.Crone, B.Hong, B.S.Caffo, P.Bhatt, F.A.Lenz, D. Boatman-Reich. Reliability of early cortical auditory gamma-band responses. Clin Neurophys. 124:70-82, 2013. PM:22771035. PMC3468656.

162. R. Zakaria, S Hua, B.H. Avin, C.C. Liu, Z. Mari, F.A. Lenz. Thalamic physiology of intentional essential tremor is more like cerebellar tremor than postural essential tremor. Brain Research. 1529: 188-199, 2013. doi: 10.1016/j.Brain Res.2013.07.011. PMC NIHMS 525557. PMC 3889719

163. T. Markman, C.C.Liu, J. N.E.Crone, J. Zhang, F.A.Lenz. Scalp EEG signals recorded over frontal and parietal cortex show task-dependent, directed functional interactions during attention to a painful stimulus. J Neurophys. 110: 2440-2449, 2013. 11/2013. doi:10.1152/jn.00246.2013, PMID: 23945784.

164. K. Kobayashi, C.C. Liu, A.L. Jensen, J.L. Vitek, Z. Mar i, F.A. Lenz . Thalamic Post-Inhibitory Bursting Occurs in Patients with Organic Dystonia more often than Controls. Brain Research. 1541: 81-91, 2013. PM:23945784. DOI : 10.1016/j.brainres.2013.10.006.

PMC3889805.

165. J.H. Chien, C.C. Liu, J.H Kim, T.M. Markman, F.A. Lenz. Painful cutaneous laser stimuli induce human event-related oscillatory EEG activities which are greater than those induced by non-

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painful electrical stimuli while the salience of the two stimuli is the same. J Neurophysiol. 112:824-

833, 2014. PMID:24848464, DOI: 10.1152/jn.00209.2014.

166. S Eliades, N Crone, W Anderson, D Ramadoss, FA Lenz, and D Boatman-Reich Adaptation of Auditory High-Gamma Responses in Human Cortex. J Neurophysiol. 2014 Nov 1;112(9):2147-63. PMID: 25122702, doi: 10.1152/jn.00207.2014.

167. R Madhavan, D Millman, H Tang, NE Crone, FA Lenz, TS Tierney, JR Madsen, G Kreiman, W Anderson. Decrease in gamma-band activity tracks sequence learning. Frontiers in Systems Neuroscience, Article 222, 2015. doi: 10.3389/fnsys.2014.00222 . PM:25653598. PMC:4300908.

168. L. Wang, X. Li, S Hsiao, FA Lenz, M. Bodner, Y-D Zhou, J Fuster. Differential Roles of Delay-period Neural Activity in Monkey Dorsolateral Prefrontal Cortex in Visual-haptic Crossmodal

Working Memory, 2014. PNAS E214-219. PM:25540412, 10.1073/pnas.1410130112 [doi]. 169. L. Zhao. L.Verhagen-Metman, J.H. Kim, C.C. Liu, F.A. Lenz. EMG and Neuronal Activity in

the Internal Globus Pallidus (GPi) and their interaction are different between Hemiballismus and Apomorphine Induced Dyskinesias of Parkinson’s disease (AID). Brain Res. 1603: 50 64, 2015. PM:25656789. 10.1016/j.brainres.2015.01.044 [doi].

170. A Qureshi,, JJ Cheng, A. Sunshine, A Wu, G Pontone, FA Lenz, S Grill, WS Anderson. Postoperative Symptoms of Psychosis after Deep Brain Stimulation in Parkinson’s Patients. Journal of Neurosurg: Neurosurg Focus . 36: E5, 2015. doi: 10.3171/2015.3.FOCUS1523.. PM:26030705.

171. CC Liu, J-H Chien, JH Kim, YF Chuang, DT Cheng, FA Lenz. Cross-frequency coupling in deep brain structures upon processing the painful sensory inputs. Neuroscience 303:412-421, 2015. doi: 10.1016/j.neuroscience.2015.07.010. PM:26168707.

172. C.C. Liu, J.H. Chien, Y. Chuang, J. Kim, D. Cheng, FA Lenz. Functional role of induced gamma oscillatory responses in processing noxious and innocuous sensory events in humans. Neurosci 303: 412-421http://dx.doi.org/10. 1016/j.neuroscience.2015.09.047, PM:26408986.

173. M.M,.Klein, R. Treister, T. Raij, A. Pascual-Leone, L. Park, T. Nurmikko, F.A. Lenz, J-P Lefaucheur, M. Lang,, M. Hallett, M. Fox, M. Cudkowicz,, A. Costellod, D.B. Carr, S.S. Ayache, A.L Oaklander. Transcranial Magnetic Stimulation (TMS) of the brain - Guidelines for Pain Studies. Pain 156:1601-14. 2016. doi: 10.1097/j.pain.0000000000000210. PM:25919472.

174. AC Schmid, J-H Chien, J.D. Greenspan, I Garonzik, N Weiss, S Ohara, FA Lenz. Neuronal Responses to Cutaneous Mechanical Stimuli and Responses to Microstimulation in the Human Principal Somatic Sensory Nucleus (ventral caudal - Vc). J Neurophysiol 115: 2421- 1233. 2016.

10:jn.00611.2015. doi: 10.1152/jn.00611.2015. PM:26864759. PMC4922463 .

175. F, Hopfner, D Haubenberger, WR Galpern, K Gwinn, A Van't Veer, S White, K Bhatia, CH Adler, D Eidelberg, W Ondo, GT Stebbins, CM Tanner, RC Helmich, FA Lenz, RF Sillitoe, D Vaillancourt, JL Vitek, ED Louis, HA Shill, MP Frosch, T Foroud, G. Kuhlenbaumer, A Singleton, CM Testa, M Hallett, R Elble, G Deuschl. Knowledge gaps and research recommendations for essential tremor. Parkinsonism Relat Disord. 33:27-35, 2016. PM:27769649, S1353-8020(16)30389-3 [pii], 10.1016/j.parkreldis.2016.10.002 [doi].

176. T. Kino, T. Tomori,; R. Abutarboush; P. Castri; Y. Chen; F.A Lenz, McCarron R.M., M. Spatz.: Human cerebromicrovascular endothelium: Characterization of functional responses induced by N-arachidonoyl-L-serine. Biochem Biophys Rep. 2016 8:254-260. PMID:28955964. PMCID:PMC5613961. doi: 10.1016/j.bbrep.2016.09.002.

177. K. Kobayashi, JH Chien, JH Kim, FA Lenz . Sensory, Motor and Intrinsic Mechanisms of Thalamic Activity related to Organic and Psychogenic Dystonia. Alz Parkin. 2017. 7: 324-329. doi: 10.4172/2161-0460.1000324. ISSN:2161-0460. NIHMS896421.

178. JH Chien, A Korzeniewska, L Colloca, CM Campbell, FA Lenz.. Oscillatory EEG Activity induced by Conditioning Stimuli during Fear Conditioning reflects Salience and Valence of these Stimuli more than Expectancy. Neurosci. 346:81-93, 2017, PMID: 28077278. NIHMS 841882. DOI:10.1016/j.neuroscience.2016.12.047. PII:S0306-4522(16)30747-3.

https://www.ncbi.nlm.nih.gov/pubmed/?term=kino+lenz

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613961/

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179. EH Kim, JH Chien, CC Liu, K Oishi, K Oishi, R Sebastian, C Demski, FA Lenz, AE Hillis. Stroke of Bad Luck? Neurocase. 23: 70-78. 2017. PM:28376690, DOI: 10.1080/13554794.2017.1296578. PMID: 28376690

180. JH Chien, L Colloca, A. Korzeniewska, CM Campbell, PM Dougherty, FA Lenz Human thalamic Ventral Caudal nucleus is a Locus for Stimulation by Signals for Noxious, Thermal and Tactile Stimuli applied to an active prosthesis. Sensors (Basel). 2017. 17(6). pii: E1197,. doi: 10.3390/s17061197, PMID: 28538681.

181. K Kobayashi,,JH Chien, JH Kim, FA Lenz . Sensory, Motor and Intrinsic Mechanisms of Thalamic Activity related to Organic and Psychogenic Dystonia. Alz Parkin. 2017. 7: 324-329. doi: 10.4172/2161-0460.1000324. ISSN:2161-0460. PMID: 28944096

182. U Malinowska, N Crone, F Lenz, M Cervenka, D Boatman-Reich. Local and Inherited Mechanisms of Adaptation in Human Auditory Association Cortex. Front Human Neurosci. 11: 247, 2017. PM:28536516, PMC5422464, https://doi.org/10.3389/fnhum.2017.00247.

183. JH Chien, A Korzeniewska, A.E. Hillis, JH Kim, N Emerson, Greenspan, J.D., CM Campbell, T.j. Meeker, TM Markman, F.A. Lenz. ‘Vigilance Behaviors and EEG Activity in Sustained Attention may Affect Acute J Syst Integr Neurosci. 3(6):1-6, 2017. doi: 10.15761/JSIN.1000184. ISSN: 2059-9781.

184. P. Gui, Y. Ku, L. Li, X. n Li, M. Bodner, F.A. Lenz, L. Wang, and Y.-D. Zhou. Neural correlates of visuo-tactile crossmodal paired-associate learning and memory in humans. Neurosci. 2017 362:181-195. PMID:28843996. doi:0.1016/j.neuroscience.2017.08.035. PMID 28843996.

185. P. Gui, J. Li, Y. Ku, Lei Li, X. Li, X. Zhou, M Bodner, F.A. Lenz, X.-W. Dong, L. Wang, Y.-D. Zhou. Neural correlates of feedback processing in visuo-tactile crossmodal paired-associate learning. Front Human Neurosci, accepted 6/8/18.

186. S Eliades, A Korzeniewska, P Franaszczuk, WS Anderson, L Birke, GK Bergey, FA Lenz, NE Crone, D Boatman-Reich. Attention and Adaptation Jointly Modulate Human High-frequency Cortical Auditory Responses. JNS – submitted.

187. E Aretouli; N Ojeda; B Gordon; TD Vannorsdall; AS Buchholz; GD Pearlson; FA.Lenz. D.J. Schretlen. Further Evidence on the Neural Basis of Neuroticism and Extraversion". PLOS1 submitted. Books: Lenz, FA, Casey KL, Jones, EG, Willis WD. The Human Pain System: Experimental and Clinical Perspectives. Cambridge Press, Cambridge UK. 2010. pp 769. ISBN 978-0-521-11452-3. B. Editorials etc:

1. Lenz, F.A. Thalamic mechanisms of pain and pain modulation. European Journal of Pain 14: 21-24, 1993.

2. Lenz, F.A., Olivi,A.O. Review of Interactive Image-guided Neurosurgery. Neurosurgery 36:1233-1234, 1995.

3. Jensen,T.S., Lenz, F.A. Central post stroke pain: a challenge for the scientist and the clinician. Pain 61:161-164, 1995.

4. Lenz, F.A. Commentary on 'A thalamic nucleus specific for pain and temperature. Craig, A.D., Bushnell, M.C., Zhang, E.T., Blomqvist, A.' Nature 372:770-773, 1994. Pain Med. J. Club Journal 2:15-17, 1996.

5. Lenz, F.A., Traill, T.A., Dougherty, P.M. Thalamic mechanisms of chest pain in the absence of cardiac pathology. Heart (formerly British Heart Journal) 75:429-430, 1996.

6. Lee J-I, Hua, S., Clatterbuck, R.E., Moriarity,J., Dougherty, P.M., Lenz, F.A. Letter to the Editor regarding Comments by L.Laitinen on ‘Starr PD, Vitek JL, Bakay RAE: Ablative surgery and deep brain stimulation for Parkinson’s disease.’ Neurosurgery 45:417, 1999.

7. J. L. Moriarity, D. Boatman, G.L. Krauss, P.B. Storm, F.A. Lenz, Letter to the Editor in

https://doi.org/10.3389/fnhum.2017.00247

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response to comments by Dr. Lehrman on Moriarity, J.L, Krauss, G.L., Boatman, D., Storm, P., Lenz, F.A. ‘Human ‘memories’ can be evoked by stimulation of lateral temporal cortex after ipsilateral medial temporal lobe resection.’ Journal of Neurology, Neurosurgery and Psychiatry. 72:823,2002.

8. F.A.Lenz, R-D. Treede. Attention, Novelty and Pain. Editorial in response to ‘Legrain V, Guérit J-M, Bruyer R, Plaghki L. Attentional modulation of the nociceptive processing into the human brain: selective spatial attention, probability of stimulus occurrence, and target detection effects on laser evoked potentials. Pain 99:1-3, 2002.

9. R-D. Treede, F.A. Lenz. Passing lanes and slow lanes into the nociceptive network of the human brain. Editorial in Response to Tsuji T, Inui K, Kojima S, Kakigi R. Multiple pathways for noxious information in the human spinal cord. Pain, 123:223-225, 2006. PM:16781065. doi:10.1016/j.pain.2006.05.014.

10. WS Anderson, F.A. Lenz. Spinal cord injury: A small step forward for spinal cord injury patients? Nature Reviews of Neurology. 7: 422-423 (August 2011). PMID: 21769125, doi:10.1038/nrneurol.2011.108.

11. WS Anderson, F.A. Lenz. Review of motor and phantom-related imagery. Neuroreport. DOI: 10.1097/WNR.0b013e32834ca58d. PMID:22009193, PMCID: PMC3208755. epub 10/15/11.

12. JD Greenspan, R-D Treede, and FA Lenz. ‘Pseudo-neglect’ in CRPS is closer to ‘Anti-neglect’ than to Classical Hemi-neglect? Commentary on Reinersmann et al. Impaired spatial body representation in Complex Regional Pain Syndrome type 1 (CRPS I). Pain. 153: 2157-2158. 2012. PMID:22871472. DOI: 10.1016/j.pain.2012.07.025.

13. M.M,.Klein, R. Treister, T. Raij, A. Pascual-Leone, L. Park, T. Nurmikko, F.A. Lenz, J-P Lefaucheur, M. Lang,, M. Hallett, M. Fox, M. Cudkowicz,, A. Costellod, D.B. Carr, S.S. Ayache, A.L Oaklander.

Reply. Pain 156:175-176, 10.1097/j.pain.0000000000000504 [doi];00006396-201605000-00027 [pii]. PM:27081841.

C. Book Chapters:

1. Tasker, R.R., Lenz, F.A., Dostrovsky, J.O., Yamashiro, K., Chodakiewitz, J. and Albe-Fessard, D. Thalamocortical contribution to sensory motor integration. In: Clinical Aspects of Sensory Motor Integration. edited by Struppler, A. and Weindl, A. Springer Verlag: Berlin, 265-276, 1987.

2. Tasker, R.R., Yamashiro, K., Lenz, F.A. and Dostrovsky, J.O. Thalamotomy in Parkinson’s disease: microelectrode techniques. In: Modern Stereotactic Surgery, edited by Lundsford, D. Academic Press: Norwell, MA, 297-313, 1988.

3. Lenz, F.A. The Thalamus and the Central Pain Syndromes: Human and Animal Studies. In: Pain in Diseases of the Central Nervous System: The Central Pain Syndromes. Edited by Casey, K. Raven Press: New York, 171-182, 1991.

4. Lenz, F.A. Neck Pain. in Principles of Ambulatory Medicine. Edited by Barker, L.R., Burton, J.R., Zieve, P.D. Williams and Wilkins: New York, 862-869, 1994.

5. Bertrand,C., Lenz,F.A. Surgical Treatment of Dystonia. In: Handbook of Dystonia. Edited by Tsui, J. and Calne, D.B. Marcel Dekker: New York, 329-346, 1995.

6. Lenz, F.A. The region postero-inferior to the human thalamic principal sensory nucleus (Vc) may contribute to the affective dimension of pain through thalamo-corticolimbic connections. In: Forebrain areas involved in pain processing. Edited by Besson, J.M., Guilbaud, G., Ollat, H. John Libby Europress: London, 119-130, 1996.

7. Lenz, F.A., Reich, S.G., Dougherty, P.M. Single neuron activity in motor thalamus is correlated with EMG activity in movement disorders. In: Advances in Clinical Neurophysiology. Excerpta Medica: Amsterdam. 689-693, 1996.

8. Rowland, L.H., Dougherty, P.M., Lenz, F.A. Microelectrode Recording. In: Textbook of Stereotactic and Functional Neurosurgery. Edited by Gildenberg P.L. and Tasker, R.R.. McGraw-Hill: New York, 935-939, 1997.

9. Mandir, A., Lenz, F.A. Clinical Neurophysiology of Parkinson’s disease. In: Textbook of Stereotactic and Functional Neurosurgery. Edited by Gildenberg, P.L. and Tasker, R.R. McGraw-Hill:

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New York, 1133-1137, 1997 ISBN . 10. Lenz, F.A. and Dougherty, P.M. Pain Processing in the Human Thalamus. In: The Thalamus.

Edited by Steriade, M., McCormick, D.A., and Jones, E.G. Elsevier Science Press: Amsterdam, 617-651, 1997.

11. Young, M.A., Hillis, A., and Lenz, F.A. Sensory sequela: Cranial central pain. In: Outcome Of Head, Neck & Spinal Trauma. Edited by MacFarlane, R. and Hardy, DG. Butterworth Heineman:New York, 1997.

12. Lenz, F.A. Ventrolateral thalamus physiology and stereotactic surgery. In: Motor Control: Syllabus of the American Academy of Neurology Course. Edited by Elble, R. AAN: Minneapolis, MN, 442- 15 to 22, 1997.

13. Lenz, F.A. Neck Pain. In: Principles of Ambulatory Medicine. Edited by Barker, L.R., Burton, J.R., Zieve, P.D. Williams and Wilkins: New York, 905-912, 1998.

14. Vitek, J.L., Lenz, F.A. Pallidotomy - a new option for the surgical treatment of dystonia. In: Pallidotomy for the treatment of Parkinson’s disease and movement disorders. Edited by Jankovic, J., Grossman, R., Krauss, J.K., Raven: New York, 267-274, 1998.

15. Mandir, A.S., Lenz, F.A. Rationales for Pallidotomy: What are the mechanisms? In: Pallidotomy for the treatment of Parkinson’s disease and movement disorders. Edited by Jankovic, J., Grossman, R., Krauss, J.K. Raven: New York, 55-66, 1998.

16. Lenz, F.A. Treatment of Central Pain. : Syllabus of the Eastern Pain Society Course. Edited by Dworkin, R. EPS: Richmond VA p 50-53, 2000.

17. Clatterbuck, R., Lee, J-I, Lenz, F.A. Lesions versus stimulation for the neurosurgical treatment of movement disorders. In: Progress in Neurological Surgery. Edited by A. Lozano. Karger: New York, 15:227-235, 2000.

18. Lenz, F.A. The evidence does not justify extending surgical procedures to the treatment of mildly affected patients with Parkinson’s disease. In: Movement disorders: Syllabus of the American Academy of Neurology Course. Edited by Goetz, C. AAN: Minneapolis, MN, 159-162, 2000.

19. Fuchs, P.N., Lee, J-I, Lenz, F.A. Central pain secondary to intracranial lesions. In: Pain Surgery. Edited by K.J. Burchiel. Thieme: New York, 459-468, 2001.

20. Dougherty, P.M., Lee, J-I, Dimitriou, T. Lenz, F.A. Medial thalamotomy. In: Pain Surgery. Edited by K.J. Burchiel. Thieme: New York, 795-802, 2001.

21. Walter, K., Lee, J-I, Lenz, F.A. Thalamotomy for essential tremor. In: Movement Disorder Surgery. Edited by Krauss, J.K., Grossman, R., Jankovic, J. Raven: New York, 271-277, 2001.

22. Lenz, F.A., Byl, N.N., Garonzik, I.M., Lee, J-I, and Hua, S.E. Microelectrode studies of basal ganglia and VA, VL and VP Thalamus in patients with dystonia: Dystonia-related activity and somatic sensory reorganization. In: Basal Ganglia and Thalamus in Health and Movement Disorders. Edited by Ilinsky, I. Kluwer Academic: NY, NY, pp 225-237, 2001.

23. Lozano,A., Shabalov, V., Ohye,C., Lenz, F.A. Thalamic surgery for tremor. In: Basal Ganglia and Thalamus in Health and Movement Disorders. Edited by Ilinsky, I. Kluwer Academic: NY, NY. pp 327-332, 2001.

24. Hua, S.E., Garonzik, I., Lee, J-I, Lenz, F.A. Thalamotomy for tremor. In: Surgical treatment of Parkinson’s disease and other Movement Disorders. Edited by Tarsy, D., Vitek, A., and Lozano, A. Humana: NY, NY, pp 99-113, 2002.

25. Lenz,F.A., Greenspan, J.D., Dougherty, P.M. Central Processing of Pain. In: Diseases of the nervous system: Clinical neuroscience and therapeutic principles. Edited by Asbury, A.K., McKhann, G., McDonald, W.I., Goadsby, P.J., McArthur, J.C. Cambridge University Press: NY, NY, pp 888-905, 2002.

26. Lenz, F.A. Neck Pain. in Principles of Ambulatory Medicine. Edited by Barker, L.R., Burton, J.R., Zieve, P.D, Fiebach, N., Kern, D.A., Thomas P., Ziegelstein, R. Williams and Wilkins: New York, pp.1049-1055, 2002.

27. F.A.Lenz Timing of Surgery in Parkinson’s disease: Surgery is not justified in patients with early PD. Moving Along: Movement Disorder Society Update 4:4-9, 2002.

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28. Lenz,F.A.,S. Ohara, I. Garonzik, S.Hua. Studies of the Thalamus in Patients with Central Pain and in Control Patients with Movement Disorders. Prog Pain Res. Clin. Manag – SCI Pain. – 219-236, 2002.

29. J. L. Moriarity, D. Boatman, G.L. Krauss, P.B. Storm, and F.A. Lenz. Memories can be evoked by stimulation of the human superior temporal gyrus after resection of ipsilateral medial temporal lobe. Search on Epilepsy 9:18-21,2002.

30. Chen, Y., R.MacCarron, Golech, S., Bembry,J., Lenz, F.A., Spatz, M. Comparative physiology and morphology of Catecholamine systems: Beta Adrenergic receptor mediated attenuation of TNFalpha-stimulated ICAM-1 expression on human brain microvascular endothelial cells. Catecholamine Research. Ed. Nagatsu, Kluwer Academic/Plenum Publishers, pp 513-17, 2002.

31. Lenz FA. N. Weiss, S. Ohara, C. Lawson, J.D. Greenspan. The role of the thalamo-cortex in pain. Clin. Neurophysiol. and Management of Pain. AAEM, Rochester, MN. pp. 45-54, 2003. PM:16106605.

32. Spatz M., Chen, Y. Golech, S., Bembry,J., Lenz, F.A., Mechoulam R., R.MacCarron. A role for cerebrovascular endothelium in ischemia and reperfusion. Maturation phenomenon in cerebral ischemia V. Buchan AM Ed. Pp 21-32, 2004.

33. Hua, S., Garonzik, I., Lee, J-I., Lenz, F.A. Thalamotomy for Tremor. In: Youman’s Neurological Surgery. W.B.Sanders: New York, 2769-2784, 2004.

34. Garonzik, I.M., Hua, S., Ohara, S., Lenz, F.A. Microelectrode recordings: Single cell and field potential recordings. In Microelectrodes in Movement Disorder surgery. Israel, Z. and Burchiel, K, Thieme Verlag:Wein, pp 249, 2004.

35. S. Ohara, N.Weiss, S.Hua, S.Anderson, C. Lawson, J.D. Greenspan, F.A. Lenz. Allodynia due to Forebrain Sensitization Demonstrated by Thalamic Microstimulation. In: Hyperalgesia: Molecular approaches and clinical treatment. Eds. K Brune and HO Handwerker. IASP Press: Seattle. 359-371, 2004.

36. FA Lenz. Deep Brain Stimulation for Parkinson’s disease. Proceedings of the North American Neuromodulation Society, 9: 43-50, 2005.

37. C. Bagley, S Ohara, FA Lenz, Human Forebrain Pathways and Networks. 11th International Pain Clinic - Congress of the World Society of Pain Clinicians. Eds. K Hanaoka, O Yuge, A Namika. Medimond - International Proceedings Division: Bologna, Italy. Pp 59-64, 2005.

38. C.A. Bagley, S. Ohara,H.C. Lawson, F.A. Lenz.Psychophysics of CNS pain-related activity: binary and analog channels and memory encoding. The Neuroscientist, 12:29-42, 2006. PMID: 16394191. DOI: 10.1177/1073858405280553.

39. W.S. Anderson, S. Ohara, H.C. Lawson, R-D. Treede, F.A. Lenz. Plasticity of pain-related neuronal activity in the human thalamus. Prog Br Res 157:353-354, 2006. PM:17046675. doi:10.1016/S0079-6123(06)57021-9.

40. S. Ohara, W.S.Anderson, H.C. Lawson, H.T. Lee, F.A. Lenz. Endogenous and exogenous modulators of potentials evoked by a painful cutaneous laser (LEPs). Acta Neurochirogie. 99:1-3, 2006. PMID: 17370769. A. Fernandez. Ohara, S. N Weiss, Anderson, F.A. Lenz. Lateral thalamic pain related cells in humans. In ‘Thalamus and Pain’ (V. Apkarian, Sect. Ed.) from ‘Encyclopedia of Pain.’ 1st edition, Eds. R Schmidt and WD Willis. Springer Verlag:Berlin. 1045-1047, 2007.

41. A. Fernandez, S. Ohara,N. Weiss, S. Ohara, S. Anderson, F.A. Lenz. Thalamus, receptive fields, projected fields, human. In ‘Thalamus and Pain’ (V. Apkarian, Sect. Ed.) from ‘Encyclopedia of Pain.’ 1st edition, Eds. R Schmidt and WD Willis. Springer Verlag:Berlin. 2454-2456, 2007.

42. R-D Treede, U Baumgärtner, FA Lenz, Nociceptive processing in the secondary somatosensory cortex: imaging and electrophysiological recording. Cortical Mechanisms of Pain (ed. KL Casey). Encyclopedia of Pain. 1st edition, (eds. R. Schmidt and W.D.Willis), Springer Verlag:Berlin. 1376-1379, 2007.

43. S. Anderson, S. Ohara, N. Weiss, F.A.Lenz. Neurophysiology and psychophysics of Angina Pectoris. In ‘Thalamus and Pain’ (V. Apkarian, Sect. Ed.) from ‘Encyclopedia of Pain.’ 1st edition, Eds.

http://dx.doi.org/10.1016/S0079-6123%2806%2957021-9

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R Schmidt and WD Willis. Springer Verlag:Berlin. 90-91, 2007. 44. Taghva A., Patel S.H., Fernandez A., Weiss N., Lenz F.A. Thalamic Bursting Activity, Chronic

Pain. . In ‘Thalamus and Pain’ (V. Apkarian, Sect. Ed.) from ‘Encyclopedia of Pain.’ 1st edition, Eds. R Schmidt and WD Willis. Springer Verlag:Berlin. 2410-2412, 2007.

45. N.Weiss, I.Garonzik, A. Samdani, S. Ohara, F.A.Lenz. Deep Brain Stimulation In ‘Neurosurgical Treatment of Pain’ (FA Lenz, Sect. Ed.) from ‘Encyclopedia of Pain.’ 1st edition, Eds. R Schmidt and WD Willis. Springer Verlag:Berlin. 528-531, 2007.

46. K.W. Li, F.A. Lenz. Implantable Pumps for Drug Delivery. In ‘Neurosurgical Treatment of Pain’ (FA Lenz, Sect. Ed.) from ‘Encyclopedia of Pain.’ 1st edition, Eds. R Schmidt and WD Willis. Springer Verlag:Berlin. 1739-1741, 2007.

47. Taghva A., Patel S.H., Fernandez A., Weiss N., Lenz F.A. Central pain, human studies of Physiology. In ‘Central Pain’ from ‘Encyclopedia of Pain.’ 1st edition, Eds. R Schmidt and WD Willis. Springer Verlag:Berlin. 324-326, 2007.

48. F.A.Lenz. Section Summary of the Neurosurgical Treatment of Pain. Section on the Neurosurgical Treatment of Pain. 1st edition, (ed. FA Lenz). Encyclopedia of Pain (eds. R. Schmidt and W.D.Willis), Springer Verlag:Berlin. 1327-1331, 2007.

49. FA Lenz, ‘Neurosurgical Procedures for Neuropathic Pain’ In ‘Pain’ (Section eds: TS Jensen, F Cervero). Handbook of Neurology. Eds. M. Aminoff, F. Boller, DF Swaab. Elsevier: Amsterdam. 81: 869-886, 2006.

50. Bagley, C.A., Garonzik, I.M., Lenz, F.A. Neck Pain. in Principles of Ambulatory Medicine. Edited by Barker, L.R., Burton, J.R., Zieve, P.D, Fiebach, N., Kern, D.A., Thomas P., Ziegelstein, R. Williams and Wilkins: New York, 1157-1164, 2007.

51. S. Ohara; C.A. Bagley; H.C. Lawson; F.A. Lenz. Psychophysics of sensations evoked by stimulation of the human central nervous system. Handbook of the Senses. (eds. AI Basbaum, RR Hoy, A Kaneko, T Sejnowski, G Shepherd, G Westheimer), Volume on Pain (eds. MC Bushnell, D Julius), .in press.

52. FA Lenz, Ablative procedures. In ‘Parkinson’s disease and Related Disorders’ (Section ed: W Koller and E Melamed). Handbook of Neurology. Eds. M. Aminoff, F. Boller, DF Swaab. Elsevier: Amsterdam 84: 241-260, 2006.

53. H.C. Lawson, S Ohara, JD Greenspan, RC Coghill, FA Lenz. Neurophysiological Cingulate Pain Responses and neurosurgical pain interventions. In Cingulate Neurobiology & Disease. BA Vogt, editor, Oxford University Press. pp. 401-417, 2009. ISBN-13: 978-0198566960.

54. WS Anderson, FA Lenz. Deep Brain Stimulation for Movement Disorders Nature Clinical Practice: Neurology. 2:1-11, 2006. PMID: 16932575. doi:10.1038/ncpneuro0193. 22 March, 2006.

55. D.S. Veldhuijzen, J.D. Greenspan, R.C. Coghill, R-D Treede, J.H. Kim, S. Ohara, F.A. Lenz. Imaging central pain syndromes. Current pain and headache. 11:183-189, 2007. PMID: 17504645

56. J.D. Greenspan, R-D Treede, R.R.Tasker, F.A. Lenz. Chapter 28, Central pain states. Bonica’s Management of Pain. Eds. SM Fishman, JC Ballantyne, JP Rathmell.. Lippincott, Williams and Wilkens. pp 358-374, 2008. ISBN-13: 978-0781768276

57. R. Hurley, R, Lenz FA. The neurosurgical treatment of cancer pain. In: Cancer Pain: Assessment and Management. Second Edition, edited by E. D. Bruera and R. K. Portenoy. New York: Cambridge University press. pp 329-342, 2009. ISBN: 9780803601710.

58. W.S. Anderson, R.E. Clatterbuck, M.D, K. Kobayashi, J-H Kim, F.A. Lenz. Lesions versus implanted stimulators in functional neurosurgery. Springer-Verlag, Berlin. Textbook of Stereotactic and functional neurosurgery. AM Lozano, PL Gildenberg, RR Tasker. eds. pp 1349-1358, 2009. ISBN 10: 0070236046.

59. K. Kobayashi, J-H Kim, W.S. Anderson, F.A. Lenz. Neurosurgical treatment of tremor. In R Winn ed, Youman’s Neurological Surgery. Saunders: New York, Chapter 78. pp 932-937, 2011. ISBN-13: 978-1416053163

60. W.S. Anderson, K. Kobayashi, J-H Kim, F.A. Lenz. Thalamotomy. In C. Comella, Encyclopedia of Movement Disorders, Elsevier: New York. Chapter 527, 2010. ISBN-13: 978-

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0123741011. 61. Anderson WS, Lenz FA. Lesioning and stimulation as surgical treatments for psychiatric

disorders. Neurosurg Quart 2009; 19(2):132-143. 62. D.S. Veldhuijzen, F.A. Lenz, S. LaGraize, and J.D. Greenspan. What (if anything) can

Neuroimaging tell us about Central Pain? In L. Kruger and A. Light eds. Chronic Pain Syndromes. NY, NY: Raven. Pp 316-329, 2010. ISBN-13: 978-1-4398-1209-9. 63. WS Anderson, J Winberry, CC Liu, C Shi, FA Lenz.Microelectrode Recordings in

Neurosurgery. Contemporary Neurosurg. 23(3): 1-8, 2010. 64. MJ Dorsey, FA Lenz, Neurosurgical Treatment of Pain. In Eds M Koltzenburg, S.McMahon,

Koltzenburg,M.; Tracy,I.; Turk,D.C.. 6th Edition of Wall and Melzack's Textbook of Pain. New York: Elsevier. 563-569. 2013 ISBN 0443067910.

65. J.Cheng, D.S. Veldhuijzen, J.D. Greenspan, and F.A. Lenz. Deconstructing Central Pain With Psychophysical and Neuroimaging studies. In Ed. P Bright, Neuroimaging volume 3. InTech publishing, Cambridge, UK. ISBN 978-953-307-1400-4, pp 451-462, 2011. DOI: 10.5772/908, ISBN 978-953-51-0097-3.

66. Weiss N, Liu CC, Anderson WS, FA Lenz , Pain-related Plasticity of Human Thalamic Receptive Fields and Projected Fields. In R. Schmidt and G. Gebhart eds. Encyclopedia of Pain, 2nd edition, Springer, Berlin. 3929-3933, 2013. ISBN – 978-3-642-28752-7

67. Garonzik I, Weiss N, Samdani A, Wicks ET, Lenz FA. Deep Brain Stimulation. In (FA Lenz, Sect. Ed) R. Schmidt and G. Gebhart eds. Encyclopedia of Pain, 2nd edition,Springer, Berlin 868-872. ISBN - 978-3-642-28752-7

68. Li KW, Lenz FA Implantable Pumps for the Treatment of Pain. In (FA Lenz, Sect. Ed) R. Schmidt and G. Gebhart eds. Encyclopedia of Pain, 2nd edition Springer, Berlin. 2752-2756. ISBN - 978-3-642-28752-7.

69. Weiss N, Bagley CA, Lenz FA. Central Pain: Human Studies of Physiology. In R. Schmidt and G. Gebhart eds. Encyclopedia of Pain, 2nd edition,Springer, Berlin. 540-542, 2013. ISBN - 978-3-642-28752-7

70. Anderson WS, Liu CC, Shi CQ., Lenz, FA. Pain-related cells in human thalamus. In R. Schmidt and G. Gebhart eds. 1708- 1711. 2013. ISBN - 978-3-642-28752-7.

71. Anderson WS, Liu CC, Weiss N, Lenz FA.Thalamic Bursting Activity and Chronic Pain. In R. Schmidt and G. Gebhart eds. Encyclopedia of Pain, 2nd edition, Springer, Berlin. 3869-3872. 2013. ISBN - 978-3-642-28752-7.

72. Lenz, FA Section Summary of the Neurosurgical Treatment of Pain. In R. Schmidt and G. Gebhart. Encyclopedia of Pain, 2nd edition,Springer, Berlin. pp 2126-2132, 2013. ISBN - 978-3-642-28752-7.

73. Zhang. J, Liu CC, Fuchs, P.N., Lee, J-I, Lenz, F.A. Central pain secondary to intracranial lesions. In: Pain Surgery. Ed K.J. Burchiel. Thieme: New York. Section 42.4. pp 42–62, 2013. ISBN 3-13-125981-7.

74. T.M. Markman, C.C.Liu, J. Zhang, K.Kobayashi, J.H. Kim, F.A.Lenz. Proceedings of SfN Symposium: Thalamic burst firing in response to experimental pain and in patients with chronic neuropathiLc pain may be a carrier for pain signals. in Ed. CY Saab ‘Chronic Pain and Brain Abnormalities’. Elsevier, New York. pp 41-60, 2013. ISBN: Print Book ISBN :9780123983893, eBook ISBN :9780124058965

75. W. S. Anderson. R. E. Clatterbuck. K. Kobayashi J.-H. Kim . F. A. Lenz, Lesions Versus Implanted Stimulators in Functional Neurosurgery in eds AM Lozano, PL Guidenberg, RR Tasker. Textbook of Stereotactic and Functional Neurosurgery. Springer: Berlin. 2013. 1349-1358. ISBN 13: 9780070236042.

76. R. Goodwin, TS Tieney, F.A. Lenz, WS Anderson. Microelectrode Recordings in Deep Brain Stimulation Surgery. Edited by I Fried, U Rutishauser, M Cerf, G Kreiman. Single Neuron Studies of the Human Brain. MIT, London UK. 75-294 2014. ISBN: 9780262027205.

77. JH Chien, JH Kim, JJ Cheng, CC Liu, JD Greenspan, FA Lenz. Controversies in the

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Mechanism of Central Pain. In ed A. V. Apkarian: The brain adapting with pain: Contribution of neuroimaging technology to pain mechanisms. IASP Press, Seattle. 2015. 359-370. ISBN 978-953-307-1400-4.

78. JJ Cheng, WS Anderson and F.A. Lenz, Neurological indications for DBS. In Brain Stimulation Methodologies and Indications. Wiley, NY NY. Ed IM Reti, 2016. 371-384. DOI: 10.1002/9781118568323.ch16, Print ISBN: 9781118568293, Online ISBN: 9781118568323.

79. J.H. Chien, J.J. Cheng, F.A. Lenz. The Thalamus.Chapt 13. In: Conn’s Translational Neurosciences. P.M. Conn Ed. NY,NY. Elsevier 2016. 289-297.. ISBN 9780128023815. http/doi.org/10.1016/B918-0-12-802381-5.000212-X.

80. J.J. Cheng, J.H. Chien, K. Kobayashi, J.H. Kim, L. Colloca, W.S. Anderson, F.A. Lenz.

Thalamotomy and Mesencephalotomy for the Treatment of Tremor and Chronic Pain. in 'Reference Module in Neuroscience and Biobehavioral Psychology'. Elsevier. 2017. 71-74.

http://dx.doi.org/10.1016/B978-0-12-809324-5.00835-X, ISBN 9780128093245.

D. Abstracts: 1. Lenz, F.A., Tasker, R.R., Bruce, I.C. and Tatton, W.G. The EMG response to displacement of

several upper limb joints in the squirrel monkey. The Physiologist 23: 22, 1980. 2. Lenz, F.A., Tasker, R.R., Bruce, I.C. and Tatton, W.G. The EMG response to joint

displacement in flexors and extensors of the squirrel monkey forelimb. Can. Physiol. 11: 98, 1980. 3. Lenz, F.A., Tasker, R.R. and Tatton, W.G. The effect of cortical lesions on reflex responses to

torque perturbations in the squirrel monkey forelimb. Soc. Neurosci. 7: 560, 1981. 4. Lenz, F.A., Tasker, R.R. and Tsuda, T. MCA occlusion in the squirrel monkey: 'clinical picture'

and torque motor studies. Neurology 31: 49, 1981. 5. Lenz, F.A., Schloegel, S., Tatton, W. and Tasker, R. Mechanical properties of the primate

forelimb during imposed displacement. Soc. Neurosci. Abstr. 8: 535, 1982. 6. Lenz, F.A., Tatton, W.G. and Tasker, R.R. The reflex response to displacement of several

forelimb joints in normal and lesioned squirrel monkeys. Can. J. Neurol. Sci. 9: 276, 1982. 7. Lenz, F.A., Lenz, Y.E., Schloegel, S., Tatton, W.G. and Tasker, R.R. The influence of reflex

activity on mechanical properties of the primate forelimb during imposed displacement. Can. J. Neurol. Sci. 11: 326, 1984.

8. Lenz, F.A., Tasker, R.R., Kwan, H.C., Schnider, S., Kwong, R. and Murphy, J.T. Single unit analysis of the ventral tier of lateral thalamic nuclei in patients with parkinsonian tremor. Soc. Neurosci. Abstr. 11: 1164, 1985.

9. Dostrovsky, J.O., Tasker, R.R., Yamashiro, K., Albe-Fessard, D. and Lenz, F.A. Sensations evoked by microstimulation in human thalamus. Proceedings of the International Union of Physiological Societies 26: 571, 1986.

10. Dostrovsky, J.O., Tasker, R.R., Yamashiro, K., Albe-Fessard, D. and Lenz, F.A. Sensations evoked by microstimulation in human ventral thalamus in relation to neuronal receptive fields. Soc. Neurosci. Abstr. 12: 329, 1986.

11. Lenz, F.A., Dostrovsky, J.O. and Tasker, R.R. Functional organization of human somatosensory thalamus. Soc. Neurosci. Abstr. 12: 329, 1986.

12. Lenz, F.A., Tasker, R.R. and Dostrovsky. J.O. Human thalamic single unit activity in central pain. Pain 4S: 347, 1987.

13. Lenz, F.A., Tasker, R.R., Kwan, H.C., Schnider, S., Kwong, R., Dostrovsky, J.O. and Murphy, J.T. Platform Presentation: The mechanism of parkinsonian tremor: Results from systems analysis of the human central nervous system. Proceedings of the American Association of Neurologic Surgeons 182, 1987.

14. Tasker, R.R., Dostrovsky, J.O., Lenz, F.A., Yamashiro, K. and Gorecki, J. Thalamic microelectrode recording and microstimulation in central and deafferentation pain. Proceedings of the American Society for Stereotactic and Functional Neurosurgery 85, 1987.

15. Gorecki, J., Tasker, R.R., Hirayama, T., Lenz, F., and Dostrovksy, J.O. Microelectrode

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recording from the deafferented thalamus. Proceedings of the American Association of Neurologic Surgeons 323, 1988.

16. Hirayama, T., Tasker, R.R., Gorecki, J., Dostrovsky, J.O. and Lenz F.A. Abnormal thalamic neuronal activity in patients with central and deafferentation pain. Proceedings of the American Association of Neurologic Surgeons 334, 1988.

17. Dostrovsky, J.O., Hirayama, T., Gorecki, J., Lenz, F.A. and Tasker, R.R. Is there a physiological marker for central and deafferentation pain? Proceedings of the Joint Meeting of the Canadian and American Pain Societies 104, 1988.

18. Lenz, F.A., Dostrovsky, J.O., Kwan, H.C., Hiryama, T., Gorecki, J., Tasker, R., Lenz, Y. Do calcium spikes account for the bursts of action potentials which occur in sensory thalamus of central pain patients? Soc. Neurosci. Abstr. 14: 561, 1989.

19. Lee, L., Dostrovsky, J.O., Tasker, R.R., Lenz, F.A. Relationship of thalamic neuronal responses and microstimulation evoked sensations elicited at the same sites in man. Soc. Neurosci. Abstr. 15: 384, 1989.

20. Lenz, F.A., Dostrovsky, J.O., Lee, L., Tasker, R.R. Mismatch between neuronal receptive fields and projected fields evoked by microstimulation in sensory thalamus of patients with spinal cord injury. Soc. Neurosci. Abstr. 15: 384, 1989.

21. Lenz, F.A., Normand, S., Kwan, H., Andrews, D., Tasker R., and Dostrovsky, J.O. Statistical estimation of the target for relief of parkinsonian tremor. Functional and Stereotactic Neurosurgery 54: 214, 1990.

22. Lenz, F.A., Guilbaud, G. and Willis, W.D. Symposium: Thalamic mechanisms of pain following peripheral injury. Pain 5S: 473, 1990.

23. Lenz, F.A., Kwan, H.C., Martin, R., Tasker, R., Dostrovsky, J.O. Characteristics of spontaneous neural activity at different locations in ventrocaudal thalamus of patients with spinal cord transection. Pain 5S: 493, 1990.

24. Lenz, F.A., Seike, M., Lin, Y.C., Richardson, R.T., Baker, F.H. and Gracely, R.G. Sensations evoked by stimulation in the area of the human ventrocaudal nucleus. Soc. Neurosci. Abstr. 17: 294, 1991.

25. Seike, M., Lenz, F.A., Lin, Y.C., Baker, F.H., Gracely, R.G. and Richardson, R.T. Neurons in human Vc respond to noxious heat stimuli. Soc. Neurosci. Abstr. 17: 294, 1991.

26. Lenz, F.A., Seike, M.S., Jaeger, C.J., Lin, Y.C., DeLong, M.R., Tasker, R.R., Vitek, J. Single unit analysis of thalamus in dystonia. Movement Disorders 7, Supp. 1: 126, 1992.

27. Lenz, F.A., Jaeger, C.J., Seike, M.S., Lin, Y.C., DeLong, M.R., Tasker, R.R., Vitek, J. Crosscorrelation analysis of thalamic neuronal and EMG signals in in dystonia. Movement Disorders 7, Supp. 1:126, 1992.

28. Lenz, F.A., Jones, E.G., Apkarian, A.V. and Bushnell, M.C. Plenary Symposium: Thalamic Mechanisms of Nociception. Soc. Neurosci. Abstr. 18: 454, 1992.

29. Lin, Y.C., Gracely, R.H., Lenz, F.A., Baker, F.H., Rowland, L.H., Dougherty, P.M., Richardson, R.T. Sensations Evoked by Microstimulation in the Area of the Ventrocaudal Nucleus of Thalamus (Vc) in Patients with Chronic Pain. Soc. Neurosci. Abstr. 19: 1572, 1993.

30. Lenz, F.A., Gracely, R.H., Hope, E., Baker, F.H., Rowland, F.H., Dougherty, P.M., Richardson, R.T. Microstimulation in the Area of Human Vc can evoke the Sensation of Angina. Soc. Neurosci. Abstr. 19: 1572, 1993.

31. Berkeley, K.G., Jansens,J., Giamberdino,M.A., McMahon,S.B. and Lenz, F.A. Symposium: New insights into mechanisms of visceral pain. Proceedings of the Seventh World Congress on Pain 239, 1993.

32. Boivie, J., K.L.Casey, K.L., Cesaro,P., Jones,E.G., Lenz,F.A., Leijon,G., Wiesenfeld-Hallin, Z. Symposium: Central Pain. Proceedings of the World Congress on Pain 7: 484, 1993.

33. Lenz, F.A., Gracely, R.H., Rowland, L.H., Dougherty, P.M. Neurons in the human thalamic principal sensory nucleus respond to painful mechanical stimuli. Proceedings of the American Pain Society 94: 846, 1994.

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34. Lenz, F.A., Gracely, R.C., Rowland, L.H., Dougherty, P.M. Neurons in the human thalamic principal sensory nucleus respond to painful mechanical stimuli. Soc. Neurosci. Abstr. 20: 1572, 1994.

35. Jaeger, C.J., Lenz, F.A., Seike, M.S., Lin, Y.C., DeLong, M.R., Dougherty, P.M., Vitek. J.L. Single unit analysis of thalamus in patients with cerebellar tremor. Movement Disorders 9, suppl. 1: 22, 1994.

36. Dougherty, P.M., Rowland, L.H., Li, Y-J., Lenz, F.A., Mittman, S. Effects of two classes of general anesthetics on responses of neurons in the primate sensory thalamus. Soc. Neurosci. Abstr. 21: 103, 1995.

37. Mittman, S. Rowland, L.H., Li, Y-J., Lenz, F.A., Dougherty, P.M. Characterization of the responses of neurons in the primate sensory thalamus to excitatory amino acids. Soc. Neurosci. Abstr. 21: 203, 1995.

38. Li, Y-J., Mittman, S. Rowland, L.H., Lenz, F.A., Dougherty, P.M. Exitatory amino acid antagonists attenuate the responses of neurons in primate sensory thalamus to cutaneous stimuli. Soc. Neurosci. Abstr. 21: 103, 1995.

39. Lenz, F.A., Gracely, R.H., Romanoski, A.J., Hope, E.J., Rowland, L.H., Dougherty, P.M. Pain with a strong affective dimension reproduced by stimulation of the human somatosensory thalamus. Soc. Neurosci. Abstr. 21: 1444, 1995.

40. Kulshreshtha, N., Rowland, L., Lawson, C., Mao, C., Lenz, F.A., Dougherty, P. and Oppenheimer, S. Distribution of Cardiovascular related sites within the human thalamus. Soc. Neurosci. Abstr. 21: 637, 1995.

41. Lenz, F.A. Relationship between thalamic neuronal and EMG activities recorded in patients with movement disorders. Electroencephalog. Clinical Neurophysiol. 97: S57, 1995.

42. Zirh, A., Lenz, F.A., Garonzik, I.M., Richardson, R.T., Ringkamp, M., Rowland, L.H., Dougherty, P.M. Characteristics of neuronal activity in the region of the thalamic nucleus Vc in patient with amputations. Soc Neurosci Abstr. 22: 1054, 1996.

43. Dougherty, P.M., Rowland, L.H., Zirh, A.T. Lenz, F.A. Comparison of effects of intradermal capsaicin on cells in the primate spinal trigeminal and dorsal column nuclei. Soc Neurosci Abstr. 22: 868, 1996.

44. Lenz, F.A., Hillis, A., Gracely, R.H., Rowland, L.H., Delano, M.C. Eckel, T.S., Bryan, R.N., Dougherty, P.M. Subtle neglect of a non-painful part of the body in a chronic pain patient reversed by intralaminar thalamotomy. Soc Neurosci Abstr. 22: 965, 1996.

45. Rios, M., Lenz, F.A., Cho, D., Krauss, G., Breiter, S., Lesser, R.P. Laser evoked potentials recorded from the human cingulate cortex. Proceedings of the Eighth World Congress on Pain 8: 441, 1996.

46. Dostrovsky, J.O., Craig, A.D., Lenz, F.A., Ralston H.J. Symposium: Thalamic mechanisms of pain processing. Proceedings of the World Congress on Pain 8: 99, 1996.

47. Lenz, F.A., Jeanmonod, D., Willis, W.D., Nauta, H.J.W. Symposium: Newer neurosurgical approaches to pain. Proceedings of the World Congress on Pain 8: 324, 1996.

48. Dougherty, P.M., Li Y.J., Rowland, L.H., Lenz, F.A. Sensitization of primate spinomesencephalic neurons by capsaiscin is paralleled by facilitation of responses to excitatory amino acids. Proceedings of the World Congress on Pain 8: 40, 1996.

49. Greenspan, J.D., Lee, R.R., Lenz, F.A. Pain threshold elevations associated with lesions of the parasylvian cerebral cortex. Soc. Neurosci. Abstr. 23: 440, 1997.

50. Dougherty, P.M., Weng, H.R., Rowland, L.H., Schwartz, A., Vierck, C.J., Lenz, F.A. Spinal cord lesion produces alterations in neurophysiologic properties of thalamic neurons. Soc. Neurosci. Abstr. 23: 159, 1997.

51. Rhios, M., Lenz, F.A., Chau, D., Krauss, G., Zirh, T.A., Breiter, S., Lesser, R.P. Laser evoked potentials recorded from the human cingulate and parasylvian cortex. Soc. Neurosci. Abstr. 23: 440, 1997.

52. Weng,P.M., Dougherty, P.M., Schwartz, H.R., Rowland, L.H., Lenz, F.A. Characterization of windup of STT neurons in the primate. Neurosci. Abstr. 24: 2081, 1998.

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53. Dougherty, P.M., Weng, H.R., Dimitiriou, P.D., Schwartz, A., Vierck, C.J., Rowland, L.H. and Lenz, F.A. Deafferentation induced changes in macaque somatosensory thalamus (VPL) following dorsal column and spinothalamic tract lesions. Soc. Neurosci. Abstr. 24: 2082, 1998.

54. Hallett, M., Byl, N., Nudo, R., Lenz, F.A. Reorganization of sensorimotor maps in dystonia. Soc. Neurosci. Abstr. 24: 1, 1998.

55. Antezana, D.F., Lee, J-I, Dougherty, P.M., Lenz, F.A. Responses of neurons in the region of human thalamic somatosensory nucleus to mechanical and thermal stimuli graded into the painful range. Abstr. IASP 9:151, 1999.

56. Hua, S.E., and Lenz, F.A. Single unit analysis of the human ventral thalamic nuclear group: correlation with thalamic activity with essential tremor. Soc neurosci. Abstr 30:257, 2000.

57. Lenz, F.A., Rowland, L.H., Dougherty, P.M., Lee, J-I. Sensations evoked by stimulation in the principal sensory nucleus of thalamus by bursts of different numbers of impulses at different frequencies. Soc neurosci. Abstr 30:2105, 2000.

58. Vogel H, Treede RD, Port J, Solaiyappan M, Krauss G, Lenz FA Dipolquellenanalyse subdural abgeleiteter Laser evozierter Potenziale aus dem parasylvischen Kortex des Menschen. Klin Neurophysiol 31: 191.

59. Greenspan, JD, Coghill RC, Rosier EM, Gilron I, and Lenz FA. Anterior Cingulotomy Effects on Thermal Pain Sensation and PET responses. Congr Proc IASP 10:76:P72, 2002.

60. Sarlati E., Lenz F, Greenspan J. Two mechanisms of cold allodynia in central pain. Congr Proc IASP 10:94:P90, 2002.

61. Garonzik IM, Ohara S, Hua SE, Belzberg A, Lenz FA. Sites in the region of the thalamic principal somatic sensory nucleus (Vc) and VMpo where threshold microstimulation (TMIS) evokes thermal (cold and warm sites) or pain sensations (pain sites). SNS Abstracts CD, 2002

62. Ohara S, Garonzik IM, , Hua SE, Lenz FA. Threshold microstimulation (TMIS) in the region of the human thalamic principal somatic sensory nucleus (Vc) evokes sensations like those of mechanical stimulation and movement. SNS Abstracts CD, 2002.

63. Sinai A, Bowers CW, Gordon B, Lesser RP, Lenz F, Crone NE. Cortical mapping of language with subdural electrodes: a direct comparison of electrocorticographic gamma activity with electrical cortical stimulation mapping. AES Abstracts, 2004.

64. Lenz FA. Mechanisms of Human Forebrain Pain Processing. Program and Abstracts of the International Pain Clinic World Society of Pain Clinicians. 11:74, 2004.

65. Nirit Weiss, Shinji Ohara, Frederick A. Lenz. Human Thalamic Vim is Involved in Motor Imagery. AANS Abstracts 2003.

66. S Hua, FA Lenz. Ventral Lateral Thalamic Activity in Essential Tremor Differs from Cerebellar Intention Tremor. AANS abstracts, 2004.

67. H. Chen, S. Hua, FA Lenz, R Shadmehr. Thalamotomy and thalamic DBS in a voltage dependent manner impairs motor adaptation in patients with essential tremor. AASFN abstracts, 2004.

68. SE Hua, A Fernandez, FA Lenz. Sites of Tremor Reduction by Microelectrode Stimulation are Posterior and Inferior to the STN. CNS abstracts, 2004.

69. HC Lawson, Ohara S, Greenspan J, Lenz FA Quantitative Sensory Testing Demonstrates Distributed Pattern of Modality Representation in Parasylvian Cortex. AANS abstracts 2005.

70. Lenz FA, Human Forebrain Pain-related Activity: Pathways and Networks. Rachidian Soc Abstr, 13:20, 2005.

71. Lenz FA, Human Forebrain Activity in Dystonia: Dystonia-related activity and Somatic Sensory Reorganization. Rachidian Soc Abstr, 13:23, 2005.

72. Koubeissi MZ, Sinai A, Lenz FA, Lesser RP, Crone NE. Functional Connectivity between Perisylvian and Bilateral Basal Temporal Cortex. AAN Abstr. Neurology. 2006.

73. Kino T, Tomori T, Chen Y, Okada T, Teranishi K, Lenz F, Mechoulam R, Shohami E, McCarron RM, Spatz M. Signal transduction pathway induced by 2-arachidonoyl-glycerol in human cerebral microvascular endothelial cells. SNS Abstracts, 2011.

74. A Keller, RR Llinas, FA Lenz, MC Bushnell, C Saab. Plenary Symposium: Chronic pain and

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anomalous brain physiology. SFN Abstr 2011. 75. CC Liu, JC Zhang, TM Markman, C Boone, NE Crone, PJ Franaszczuk, DT Cheng, FA Lenz.

Fear conditioning is associated with functional interactions between and within the human amygdala, hippocampus, and frontal lobe. SFN Abstr 2012.

76. Castri P, Kino T, Chen Y, Abutarboush R, Lenz F, Shohami E, Mechoulam R, McCarron RM, Spatz M. Human Cerebral Microvascular Endothelium: Linoleoyl Ethanoliamide, a novel natural lipid substance, is a potential vasodilator SfN Abstracts 2014.

77. Kino T, Tomori T, Castri P, Chen Y, Lenz F, Abutarboush R, McCarron RM, Spatz M. Cerebromicrovascular human endothelium: Characterization of functional responses induced by arachidonoyl serine. SfN Abstracts 2014.

78. Laura Groomes, R. Madhavan, F Azhar, H Tang, NE Crone, J Madsen, A Golby, FA Lenz, G Kreiman, WS Anderson. Cognitive Consequences of Interictal Spikes. AES Abstracts, 2014.

79. Chien J-H, Lenz FA, Schmid A-C, Cheng D-T, Anderson WS, Liu C-C. Contextual fear conditioning in humans using a painful cutaneous laser. SfN Abstracts 1015.

Extramural Sponsorship (current, under review, previous): Grants (completed):

The New York Academy of Medicine PI- F.A. Lenz Elsberg Award $30,000.00 (1988-89).

The Charles A. Dana Foundation PI - F.A. Lenz Neuroscience Fellowship $40,000.00 (1988-89). Eli Lilly Clinician Scientist Award PI - F.A. Lenz $100,000.00 (1989-91). NIH PI - F.A. Lenz Studies of the Ventrocaudal Thalamus in Human Pain K08 NS 01384 $356,400.00 (1989-94). NIH PI - F.A. Lenz Studies of the Ventrocaudal Thalamus in Human Pain R29 NS28598 $566,271.00 (1990-95). NIH PI - F.A. Lenz Ventrocaudal Thalamus in Thermal and Pain Sensation Project I, P01 NS32386, 'Studies of Neuropathic Pain' $1,036,355 (1994-99). NIH/NIA

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PI - F.Bylsma, Co-PI - F.A.Lenz. Neuropyschologic effects of pallidotomy in Parkinson’s disease. P50 AG05146 Alzheimer's Disease Research Center: Clinical Core P.D. C.K.Kawas

$20,000 (1994-95). NIH/NIA PI – J.Brandt, Co-PI - F.A.Lenz Neuropyschologic effects of pallidotomy in Parkinson’s disease. P50 AG05146 Alzheimer's Disease Research Center: Clinical Core. P.D. C.K. Kawas

$55,500 (1995- 1998).

NIH PI-F.A. Lenz, Co-PIs – P.M. Dougherty, J. Greenspan, R. Gracely, R. Treede. The biology of human cortical pain-related activity, RO1 NS38493-1. $ 1,918,564 (2000-2005). (12,339K) NIH PI – F.A. Lenz, Co-PIs – P.M. Dougherty, R. Gracely. The Ventrocaudal Thalamus in Human Pain RO1 NS40059 $1,968,291 (2000-2004).

NIH PI-F.A. Lenz, Co-PIs – N. Crone, J. Greenspan, R. Gracely, S. Ohara, R. Treede. The biology of human cortical pain-related activity, RO1 NS38493-6. $ 2,735,519 (2005-2010). NIH PI – Y-D Zhou, Co-PI – F.A.Lenz. Cortical Memory of Cross-modal Sensory Information R01 NS044919-01A2 $ 1,337,600 (2004-2009).

NIH PI-F.A. Lenz, Co-PIs – N. Crone, CC Liu, The biology of human thalamo-cortical pain-related activity, RO1 NS38493-16 – under Review. $ 2,371,592 (2011-2016). Johns Hopkins Neurosurgical Pain Research Institute. PI F.A. Lenz Basic and clinical studies of cortical stimulation sites for treatment of pain. $ 870,000 (2012-16).

Johns Hopkins Neurosurgical Pain Institute Scholar Grant Post doc N Emerson Mentors: FA Lenz with CM Campbell, L Colloca, JD Greenspan, A Korzeniewska

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Scholar Grant (Post Doctoral Fellow – Nicole Emerson), ‘ The Transition from Pain Related Attention to Vigilance’. $ 137,606 (2016-19). Blaustein Pain Research Foundation. FA Lenz , CoIs CM Campbell, L Colloca, JD Greenspan, A Korzeniewska Equipment Grant entitled Laser for Behavioral, Grid and fMRI studies of Attention to Pain. $ 10,000 (2017) Johns Hopkins Neurosurgery Pain Institute. FA Lenz (PI), CM Campbell,L Colloca, JD Greenspan, A Korzeniewska (CoIs) NPRI: 20161102140917485 Supplement to JHNPRI award Equipment Grant entitled Laser for Behavioral, Grid and fMRI studies of Attention to Pain. $ 39,376. (2017). Johns Hopkins Neurosurgical Pain Institute Scholar Grant Mentors: FA Lenz with JD Greenspan Scholar Grant (Post Doctoral Fellow – Tim Meeker. Behaviors related to Neural Activity in Experimental Vigilance. $79,385 (2017-19).

NIH F.A. Lenz (PI), Co-PIs – Crone, Campbell, Korzeniewska. Hillis. The transition from pain related attention to vigilance. 2R56NS038493-16A1. 2017-18. $550,000 NIH F.A. Lenz (PI), Co-PIs – N. Crone, A Korzeniewska, Greenspan. Behaviors related to Human Neural Activity during Experimental Vigilance to Pain. R01 NS107602-01. $2,471,103.08. 7/1/18 to 6/30/22. F.A. Lenz (PI), Co-PIs – N. Crone, A Korzeniewska, Saygin Networks for the Expectation of Pain. 1 RO1 NS096007-01 RO1 Application Study Section score 33, 16%ile.

EDUCATIONAL ACTIVITIES Teaching: - Neurosurgical Residency Training Program (within Johns Hopkins School of Medicine) - Rounds, clinic, ward and operative teaching at JHH, JHBMC. November 1988 - present. - Supervision of Research Post Doctoral Fellows (within Johns Hopkins School of Medicine) - 1988 - present.

1. Radionics Stereotactic Course. Baltimore, Maryland. February 27, 1990- Instructor. 2. Radionics Stereotactic Course. Baltimore, Maryland. April 11, 1990 - Instructor. 3. Symposium: Thalamic mechanisms of pain following peripheral injury. International association for

the study of pain meeting. Adelaide. April 5, 1990. 4. Radionics Stereotactic Course. Baltimore, Maryland. November 10, 1990 - Instructor. 5. Radionics Stereotactic Course. Baltimore, Maryland. January 21, 1991 - Instructor.

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6. Symposium: Central Pain. International Association for the Study of Pain Meeting. Paris, France. August 24, 1993 - Lecturer.

7. Symposium: New insights into mechanisms of visceral pain. International Association for the Study of Pain Meeting. Paris, France. August 26, 1993 - Lecturer.

8. Course: Thalamotomy Techniques. Annual meeting of the American Association of Neurologic Surgeons. San Diego, CA. April 11, 1994 -Lecturer.

9. Neurobiology Review Course: Canadian Congress of Neurological Sciences. London, Canada. June 29-30, 1996 - Instructor.

10. Symposium: Thalamic mechanisms of pain processing. International Association for the Study of Pain Meeting. Vancouver, Canada. August 24, 1996 – Lecturer.

11. Symposium: Newer neurosurgical approaches to pain. International Association for the Study of Pain Meeting. Vancouver, Canada. August 24, 1996 - Lecturer.

12. Practical Course: Movement Disorders. Congress of Neurological Surgeons. Montreal, Canada. September 29, 1996 - Instructor.

13. Motor control course. American Academy of Neurology. Boston, MA. April 19, 1997 - Lecturer. 14. Course: Functional studies of cortex during epilepsy surgery. American Association of Neurological

Surgeons. Denver, Colorado. April 17, 1997- Lecturer. 15. Course: Pallidotomy: Stereotactic treatment of movement disorders. American Association of

Neurological Surgeons. Denver, Colorado. April 13, 1997- Lecturer. 16. Course: Stereotactic Surgery for the treatment of Movement Disorders. Congress of Neurological

Surgeons. New Orleans, LA. October 24, 1997 - Instructor. 17. Course: Surgical treatment of movement disorders. American Association of Neurologic Surgeons.

Philadelphia, PA. April 26, 1998- Lecturer. 18. Course: Functional studies during epilepsy surgery. American Association of Neurologic Surgeons.

Philadelphia, PA. April 29, 1998 - Lecturer. 19. Course: Monitoring during functional stereotaxis. American Society of Neurophysiologic Monitoring.

Philadelphia, PA. May 3, 1998 - Lecturer. 20. Course: Neuropathic Pain. Pain clinic of University of Rochester and Allegany University. Rochester,

New York . June 5-6, 1998– Instructor. 21. Course: Neuroplasticity. American Physical Therapy Society: Section on Research. Newport, RI.

August 15-21, 1998 – Lecturer. 22. Course: Surgical treatment of movement disorders. Congress of Neurosurgeons. Seattle,

Washington. October 3, 1998 - Lecturer. 23. Course: Lateral thalamus and central pain. American Pain Society. San Diego, CA. November 6,

1998 – Lecturer. 24. Course: Movement disorders. American Association of Neurologic Surgeons New Orleans, LA. April

24, 1999– Lecturer. 25. Course: Functional studies of Cortex during epilepsy surgery. American Association of Neurologic

Surgeons. New Orleans, LA. April 26, 1999 - Lecturer. 26. Course: New neurosurgical approaches to the treatment of pain. International Association for the

Study of Pain Meeting. Vienna, Austria. August 24, 1999 – Lecturer. 27. Course: Pathophysiology of central pain secondary to spinal cord injury. International association of

the study of pain. Vienna, Austria. August 25, 1999 – Lecturer. 28. Course: Electrophysiologic studies of nociceptive inputs to cortex. International Association for the

Study of Pain Meeting. Vienna, Austria. August 23, 1999 – Lecturer. 29. Course: Pallidotomy and other surgical treatments of Parkinson’s disease. Congress of Neurologic

Surgeons. Boston, MA. November 3, 1999 - Lecturer. 30. Course: Movement Disorders. American Academy of Neurology. San Diego, CA. April 30, 2000 –

Lecturer. 31. Course: Central Pain. American Pain Society. Atlanta GA. November 2, 2000 – Lecturer. 32. Course: Visceral Pain Pathways. American Pain Society. Atlanta GA. November 5, 2000 – Lecturer.

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33. Course: Phantom Pain. American Pain Society. Atlanta GA. November 5, 2000 – Lecturer. 34. Course:Video Case Discussion: Advanced Parkinson’s disease and Dystonia. Congress of

Neurosurgeons. San Antonio, TX. September 27, 2000, Speaker. 35. Course: Treatment of Central Pain. : Eastern Pain Society. NY, NY. December 8, 2000. Lecturer. 36. Course: Surgical treatment of dystonia. Dystonia Medical Research Council. Atlanta, Georgia,

December 9-10, 2000. – lecturer. 37. Course: International Association for the Study of Pain Research Symposium on Spinal Cord Injury

Pain. Phoenix, Arizona, April 16-19, 2001 – Lecturer. 38. Course: IASP Symposium on Hyperalgesia. Erlangen, Germany. September 18, 2003 - Invited

Presentation. 39. Course: State of the art pain imaging. Congress of Neurological Surgeons. San Francisco, California.

October 19, 2004 – lecturer. 40. Course: Mechanisms and treatments of central pain. The 11th annual Kentucky Spinal Cord and

Head Injury Research Trust Symposium. Louisville, Kentucky. June 8-10 2005 - Lecturer. 41. Course: Surgical approaches to the treatment of Parkinson’s disease. National Parkinson’s

Foundation Course. Baltimore, Maryland. November 4, 2005. 42. Course: Surgical Approaches to the treatment of Essential tremor. International Essential Tremor

Foundation. Baltimore MD. November 2006. 43. Course: Brain pacemakers for treatment of neurologic and psychiatric disorders. Office on Disability:

Dept of Health and Human Services, & Cleveland Clinic. Washington DC, May 6 2008. Mentoring (pre- and post-doctoral):

- M. Seike MD, Postdoctoral Fellow Research 1990-91. Current position: Assistant Professor, Attending Neurosurgeon – Functional stereotaxis, Department of Neurosurgery Kochi Medical School. Nankoku-City, Kochi 781-51, Japan.

- Yan Chong Lin MD, Postdoctoral Fellow Research 90-92 Deceased 1997, last position: Assistant Professor Department of Neurosurgery Wenzhou Medical College. - Attending Neurosurgeon - Functional stereotaxis. No.1 Hospital Wenzhou, Zhejiang, People's Republic of China.

- Isham Khoja MD, Postdoctoral Fellow Research 1991-92. Current position: Attending Neurosurgeon, Erie General Hospital, Erie, New York, USA. C.J. Jaeger MD, Pre- and Postdoctoral Fellow Part time Research 1991-97. Current position: Hospitalist, Inpatient Managers Medical group, California Pacific Medical Center San Fransisco, California

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- A.E. Hillis PhD, MD, Pre- and Postdoctoral Trainee Part time Research 93-97. Current position: - Attending Neurologist, Johns Hopkins Hospital - Professor of Neurology, Johns Hopkins University.

- M. Rhios MD, Postdoctoral research fellow during clinical epilepsy fellowship With with R.R. Lesser 1994-96.

- Attending Neurologist, Director of Pediatric Epilepsy San Juan Hospital - Academic Staff, University of Puerto Rico. - T.A. Zirh MD, Postdoctoral fellow

Research 1995-96. - Assistant Professor, Department of Neurosurgery, Koq University - Attending Neurosurgeon - Functional Stereotaxis, American Hospital Istanbul, Turkey.

- J.I.Lee MD, Postdoctoral fellow Research 1997-99

- Current position: Assistant Professor, Department of Neurosurgery Sungkyunkwan University.

- Attending Neurosurgeon - Functional Stereotaxis, Samsung Medical Center Seoul, Korea.

- E. Leemstra MD, Predoctoral fellow Research 1999 Current position: Resident in Neurology Academic Medical Center and The Netherlands Institute for Brain Research Amsterdam, Netherlands -S. Ohara, Postdoctoral fellow - Research 2000-02

Current position: Associate professor, Chief, Division of Neurosurgery, Neuroscience

Center, Fukuoka Sanno Hospital, Fukuoka, Japan

2009–present.

- IM Garonzik, MD, Postdoctoral Trainee Research 2000-2002. Current position: Part time Assistant Professor.

Dept of Neurosurgery Johns Hopkins School of Medicine

- S. Hua, MD PhD, Postdoctoral Trainee Research Fellow 2003-2004. Current position: Assistant Professor Department of Neurosurgery University of Southern California

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- N Weiss MD, Postdoctoral Trainee

Research Fellow 2001-2004. Current position: Assistant Professor Department of Neurosurgery Mount Sinai School of Medicine, New York, New York.

- HC Lawson Research Fellow 2004-2006. Current Position: Attending Neurosurgeon. Department of Neurosurgery Greater Baltimore Medical Center.

- HT Lee Research Fellow 2005-2006 Current position: Instructor National Defence Medical Center Taichung (407), Taiwan, R.O.C. - W.S. Anderson, MD, Postdoctoral Trainee

Research and Clinical Fellow 2005-2007. Current position: Associate Professor Department of Neurosurgery JHU-SOM

- D Veldhuijzen PhD, research fellow 2005-2006, Division of Perioperative Care and Emergency Medicine, Rudolf Magus Institute of Neuroscience, Pain Clinic, University Medical Center Utrecht, Utrecht, Netherlands.

- Jong-Hyun Kim Research Fellow 2006-2009. Current position: Assistant Professor of Neurosurgery

Department of Neurosurgery, Korea University Guro Hospital,

Seoul, Korea.

- K Kobayashi. Research Fellow 2007-2009. Current position: Assistant Professor of Neurosurgery, Department of Neurological Surgery, Division of Applied Systems Neuroscience, and Department of Advanced Medical Science, Nihon University, Tokyo, Japan.

- CC Liu Post Doctoral Fellow 2009-2012. Current position: Assistant Prof of Neurosurgery JHU SoM.

- JJ Cheng PDF 2013-14 Current position: Instructor, Dept of Neurosurgery, Kansas University,

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Kansas City, Kansas.

- JH Kim Visiting Scientist 2013-2014. Current position: Assistant Professor of Neurosurgery Department of Neurosurgery, Korea University, Guro Hospital, Seoul, Korea.

- JH Chien Post Doctoral Fellow 2012-2016. Current Position: Institute of Biomedical Engineering – Nanomedicine (JHC), National Health

Research Institutions, Institute of Biomedical Engineering – Nanomedicine, – Nanomedicine (JHC).

- AC Schmid

Post Doctoral Research Fellow 2012-2016 Current Associate: Research Associate: Brain Imaging and NeuroStimulation (BINS) Laboratory University Medical Center Hamburg-Eppendorf Hamburg, Germany.

- E Bordbar Post Doctoral Research Fellow 2015-2016 Research Associate, Department of Neurology, Massachusetts General Hospital. Boston. Nicole Emerson. PhD. Post Doctoral Research Fellow 2016 - 2017.

Associate FDA Center for Pharmacologic Approaches to Opiate Addiction. Washington DC.

Tim Meeker. PhD. Post Doctoral Research Fellow 2017 to present. Johns Hopkins Neurosurgical Pain Research Institute.

Mark Saffer PhD. PDF 2018 to Present in Lenz Lab. Johns Hopkins Neurosurgical Pain Research Institute.

Editorial Activities: Peer Review Service: Editorial Boards:

- Journal of the American Pain Society, 1991-95 - Pain Forum, 1994-2000. - European Journal of Pain, 1996-2002. - The Journal of Pain, 1999-2003. - Thalamus and related systems, 2000 - 2005. - Pain – Journal of the International Assoc. for the Study of Pain. Associate Editor, 2004 -.present. - IEEE transactions on Neuro-engineering and Rehabilitation. Editorial Board: Senior Advisor. 2005. - Associate Editor, European Journal of Pain, 2008- present. - Honorary Editor, International Journal of Pain. 2008- present. - Associate Editor, PLoS ONE, 2012- present. - CME course on The 20th Annual Meeting of the American Pain Society, April 18-22, 2001 – Course

Director and Editor of the Proceedings, Medscape. NY: NY.

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- Editor for Neurosurgery: Encyclopedia of Pain, WD Willis and R Schmidt (eds). 2002 and 2014` - Associate Editor of Journal of Neurophysiology 2017 – present.

Ad hoc member of Study Section: - National Science Foundation, 1989. - International Science Foundation, 1993. - Medical Research Council of Canada, 1995.

- NIH-NINDS-IFCN-4, 1998-2000. - NIH-NINDS-BDCN-2, 2001. - NIH-NINDS-ZRG1 (IFCN-3) 05 S, 2002. - National Academy of Sciences - BRRT. 2004-2006. - National Research Council of Canada - WCI, 2004-2006. - Burroughs Wellcome Fund – 2006 -.present. - Special emphasis panels: - : ZRG1 IFCN-E (11), Parent SBIR [R43/R44]). 2007. - NINDS ZRG1 IFCN-A (58)R. 2009. - SCS reviewer Nov 2008 to June 2011 - NINDS ZNS1 SRB-E Brain Initiative U01 Review May 2018.

Regular Member of Study Section or other NIH/federal panel.

- NIH-NINDS-IFCN-4, 2000-2004. - NIH-NINDS-RFA-NS99006. - Member of DSMB of the GDNF/PSP trial of the NIH-NINDS-ETB 2000-2004. - Neurological Devices Panel-MDA Comm-Center DRH-FDA – 2003 to 2006. - ZRG1 ETTN-B (03) F, 2008-2009. Ad hoc reviewer of manuscripts, books etc: - Journal of Neurophysiology. - Pain. - Harvard University Press. - Journal of Neuroscience. - Nature (Medicine). - Experimental Brain Research. - European Journal of Pain. - Annals of Neurology. - Brain Research. - Pain Medicine Journal Club Journal. - Proceedings of the US National Academy of Sciences. - Journal of Physiology (Lond.). - Biomed Central Neuroscience. - Brain. - The Lancet. - Brain Research Interactive. - Clinical Neurophysiology. - Neuroscience. - Neuroscience Letters. - Pain Practice - Neurology (Minn.). - Movement Disorders. - Journal of Neuroscience Methods. - Journal of Neurology, Neurosurgery and Psychiatry.

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- Movement Disorders Clinical Practice. - The Lancet Neurology. - Pain medicine. - Neuroreport. - Neuromodulation. - Behavioral brain research. - New England Journal of Medicine. - IASP Press. - IEEE Transactions on Biomedical Engineering. - IEEE Transactions on Neuro-engineering. - IEEE Engineering in Medicine and Biology Society - IEEE Journal of Biomedical and Health Informatics - Experimental Neurology - Physical Review Litt. - European Journal of Neuroscience. - Progress in Neurobiology. - Neurotherapeutics. - Neurosurgery - Journal of Rehabilitation Medicine - PLoS ONE, PLOS Biology - Experimental Diabetes Research - Journal of Neural Engineering (IOP) - Pain Research and Management - Proceedings of the New York Academy of Sciences. - Molecular Pain - Acta Neurologica Scandanavica - Neuron - Pain Research and Management - Trends in Cognitive Neuroscience - Nature: Scientific Reports. - Neuroimage - Neural Plasticity - Brain Stimulation - Somatosensory and Motor Research.

Clinical Activities

Certification: 1987 Written Exam of the American Board of Neurological Surgery (94th %tile) 1987 FRCS(C) Specialist Certificate of the Royal College of Surgeons of

Canada in Neurological Surgery. 1993 Board Certified - American Board of Neurological Surgery. Activities related to Organizations: Professional Societies (membership, committees, dates, role): - New York Academy of Medicine, Member- Elsberg Scholarship Committee.

- 1996-2001. - American Pain Society, Scientific Program Committee. - 1992-1993. - American Pain Society, Nominating Committee – 1995-96. - DC Chapter of the National Parkinson Foundation, Governor

- 1995-98.

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- Johns Hopkins University Neurosciences Appointment and Promotions Committee, Member

- 1992-2001. - American Academy of Neurology TTA Committee on 'Surgical Treatment of Parkinson’s disease', Member.

- Chairman: Subcommittee on Thalamotomy. - 1996 - 2000.

- International Association for the Study of Pain Committee on Research. - 2000 – present.

- Canadian Association for Neuroscience. - Congress of Neurosurgeons. - Canadian Neurosurgical Society. - Fellow of the Royal College of Surgeons of Canada (awarded 1987). - Fellow of the American Board of Neurosurgery (awarded 1993) - Society of Neuroscience. - International Association for the Study of Pain. - American Association of Neurological Surgeons. - Movement Disorder Society.

- ‘Senior’ Society of Neurological Surgeons.

RECOGNITION

Academic Awards: 1973-74 John Melady Admission Award University of Toronto Medical School. 1979-83 Medical Research Council of Canada Fellowship.

1981 Academy Award of the American Academy of Neurosurgeons Resident Research Award – Runnerup.

1982 MacKenzie Award The Canadian Neurosurgical Society and the Royal College of Physicians and Surgeons- Canada.

1982-83 Schering Scholar The American College of Surgeons. 1985 MacKenzie Award The Canadian Neurosurgical Society, The Royal College of

Physicians and Surgeons- Canada, and the International Federation of Neurosurgical Societies.

1987 Medical Research Council of Canada Fellowship (ranked 2nd out of 346 applicants).

1988 Elsberg Award New York Academy of Medicine.

1988 Neuroscience Fellowship The Charles A. Dana Foundation.

2005 Grass Foundation Award of the ‘Senior’ Society of Neurological Surgeons - Career award for research accomplishments in Neurological Surgery.

2005-14 Best Doctors in America: Neurological Surgery. Best Doctors Inc. Aiken SC.

2009 John Loeser Lecture and Award of AANS annual meeting.

Awards for presentations at meetings etc.

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1. Poster Award of the Movement Disorder Society. Single unit and crosscorrelation analysis of thalamic neuronal and EMG signals in in dystonia. Lenz, F.A., Seike, M.S., Jaeger, C.J., Lin, Y.C., DeLong, M.R., Tasker, R.R., Vitek, J. Triennial meeting of the Movement Disorder Society, Munich, June1992.

2. A human thalamic nucleus mediating taste and other sensations related to ingestive behavior (Zirh, T.A. with Lenz, F.A., Gracely, R.H., Rowland, L.H., Leopold, D.A., Dougherty, P.M.) Twelfth Meeting of the World Society of Stereotactic and Functional Neurosurgery, Lyon, France. July 4, 1997 - Leksell Award Paper.

3. Nirit Weiss, Shinji Ohara, Frederick A. Lenz. Human Thalamic Vim is Involved in Motor Imagery. AANS annual meeting. Poster Award of the American Association of Neurological Surgery, Annual meeting, 2003.

4. S Hua, FA Lenz. Ventral Lateral Thalamic Activity in Essential Tremor Differs from Cerebellar Intention Tremor. Poster Award of the American Association of Neurological Surgery, Annual meeting, Annual meeting. 2004.

5. H. Chen, S. Hua, FA Lenz, R Shadmehr. Thalamotomy and Thalamic DBS in a voltage dependent manner impairs motor adaptation in patients with essential tremor. Poster Award of the American Association of Stereotactic and Functional Neurosurgery, Triennial meeting, 2004.

Invited Talks, Panels (title, date, venue, sponsor): 1. Central nervous system activity in patients with deafferentation and central pain. Pain

against man - Symposium of the Menarini Foundation. Florence, Italy (May 1, 1990) - Invited Presentation.

2. Thalamic mechanisms of somatic sensation and pain. Physiology Seminar Series - Visiting Professor: Department of Physiology, University of Wurzburg, FRG. May 3, 1990 - Invited Presentation.

3. Thalamic activity recorded during operative procedures for the treatment of movement disorders and pain. Visiting Professor: Department of Neuroscience, University of Heidelburg, FRG. May 5, 1990 - Invited Presentation.

4. Responses to microstimulation in the area of human ventrocaudal nucleus. Visiting Professor: Department of Physiology - University of Wurzburg, FRG. April 5, 1992 - Invited Presentation.

5. Electrophysiologic studies of human thalamus during stereotactic procedures for movement disorders and pain. Visiting Professor: German Basal Ganglia Society, Freiburg, FRD. April 10, 1992 - Invited Presentation.

6. Electrophysiologic studies of human thalamus in patients with movement disorders and pain. NINDS Grand Rounds, Bethesda, Maryland. June 5, 1992 - Invited Presentation.

7. Studies of human thalamus in acute and chronic pain. Neurology Seminar Series - Visiting Professor: Department of Neurology, Linkoping University, Sweden. June 29, 1992 - Invited Presentation.

8. Electrophysiologic and psychophysical studies of human thalamus. Annual Meeting of the American Pain Society, San Diego, CA. October 24, 1992 - Invited Presentation.

9. Symposium: Thalamic Mechanisms of Nociception. (with Jones, E.G., Apkarian, A.V. and Bushnell, M.C.) Annual Meeting of the Society of Neuroscience. October 29, 1992 – Invited presentation.

10. Thalamic activity related to movement disorders. Visiting Professor: Neurology and Neurosurgery Grand Rounds. SUNY Syracuse Health Science Center. September 15, 1993 - Invited presentation.

11. Thalamic activity in acute and chronic pain. Visiting Professor: Neuroscience

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Seminar Series. SUNY Syracuse Health Science Center. September 17, 1993 - Invited presentation.

12. Reorganization of thalamus in patients with lesions of the nervous system. Symposium honoring Ulf Lindblom, retiring Chair in Neurology, The Karolinska Institute: Touch, temperature, and pain sensation in health and disease. Wenner-Gren Foundation, Stockholm, Sweden. October 6-10, 1993 - Invited presentation.

13. Studies of human thalamus in acute and chronic pain. In: ‘New Vistas in Central Pain Mechanisms' - Symposium at the Triennial Meeting of the International Brain Research Organization (IBRO), Kyoto, Japan. July 12, 1995 - Invited Presentation.

14. Relationship between Thalamic Neuronal and EMG activities recorded in patients with Movement Disorders. Symposium at the Tenth Biennial Meeting of the International Society for Clinical Neurophysiology and Electromyography, Kyoto, Japan. October 19, 1995 - Invited Presentation.

15. The role of thalamo-corticolimbic connections in the affective dimension of acute pain. in 'Forebrain areas involved in pain processing' Symposium of the Association pour la Neuro Psycho Pharmacologie and L'Institute de Recherche International Servier. Dinard, France. May 28-30, 1995 - Invited Presentation.

16. Mechanism of the therapeutic effect of Vim stimulation upon tremor. In: 'Surgical therapies for Parkinson’s disease' - Symposium of the Movement Disorder Society. San Sebastion, Spain. June 24, 1995 - Invited Presentation.

17. Stereotactic procedures for movement disorders. Snodgrass Visiting Lecturer, Department of Neurosurgery and the Marine Biological Institute, University of Texas Medical Branch at Galveston. March 11-13, 1996 - Invited Presentation.

18. Symposium: Thalamotomy/Thalamic stimulation. Biennial International meeting of the Movement Disorder Society, Vienna, Austria. June 21, 1996 - Invited Presentation.

19. Thalamotomy for the treatment of essential tremor: An assessment using blinded measures of outcome (with Zirh, T.A., with Lenz, F.A., Reich, S.G., Rowland, L.H., Dougherty, P.M.) Plenary presentation - Annual meeting of the American of Neurological Surgeons, April 15, 1997. - Invited Presentation.

20. Human thalamic activity related to the sensory and affective dimension of pain. Symposium: Pain from molecules to perception. XXXIII International Congress of Physiological Sciences, St Petersburg, Russia. July 5, 1997 - Invited Presentation.

21. CNS activity in patients with tremor. Tremor - Symposium of the Movement Disorder Society, Kiel, FRD. July 10, 1997 - Invited Presentation.

22. Leksell Award Paper: A human thalamic nucleus mediating taste and other sensations related to ingestive behavior (Zirh, T.A. with Lenz, F.A., Gracely, R.H., Rowland, L.H., Leopold, D.A., Dougherty, P.M.) Twelfth Meeting of the World Society of Stereotactic and Functional Neurosurgery, Lyon, France. July 4, 1997 - Plenary Presentation.

23. Thalamotomy for tremor. Visiting Professor, Mayo Clinic, Rochester Minnesota, July 30, 1997 - Invited Presentation.

24. Reorganization of thalamic and pallidal activity in patients with dystonia (with Hallett, M., Byl, N., Nudo, R.). Society for Neuroscience Plenary Symposium: Reorganization of sensorimotor maps in dystonia. Los Angeles, CA. November 6, 1998 - Invited Presentation.

25. Mechanisms of Dystonia: Sensory Reorganization of the Motor System. Visiting Professor: Neurology/Neurosurgery Grand Rounds, Temple University. Philadelphia, PA. January 29, 1999 - Invited Presentation.

26. The sensory limbic model of pain memory. International Association for the Study of Pain Meeting satellite symposium on ‘Nervous system plast icity and pain. ’

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Heidelberg, FRD, August 15, 1999 - Invited Presentation. 27. Microelectrode recording f rom subcort ical sensory structures.

Symposium at the XII Biennial Meeting of the International Society for Clinical Neurophysiology and Electromyography, Prague, Czechoslovakia. September 6, 1999 - Invited Presentation.

28. Thalamic pacemakers in parkinsonian tremor. Symposium on ‘The thalamus and basal ganglia.’ The Burdenko Institute of Neurosurgery, Moscow, Russia. May 30, 2000 – Invited presentation.

29. Physiology of VA, VL and VP thalamus in patients with dystonia. Symposium on the thalamus and basal ganglia. The Burdenko Institute of Neurosurgery, Moscow, Russia. May 31, 2000 – Invited presentation.

30. Physiologic localization of Vim. Deep brain stimulation for the treatment of movement disorders. Symposium of the Movement Disorder Society. Salzau, Kiel, FRD. June 3-7, 2001 – invited presentation.

31. Human CNS pain-related activity. Dept of Anesthesiology, University of Iowa, Iowa City:Iowa. March 5-6, 2002 - Invited Presentation.

32. Human CNS activity related to movement disorders. Dept of Neuroscience, Dalhousie University, Halifax. February 25-26, 2002- Invited Presentation.

33. Human Thalamo-Cortical Pain Mechanisms - Jasper Lecturer. World Federation of Clinical Neurophysiology. San Francisco. September 8, 2003 - Invited Presentation.

34. Mechanisms of DBS for tremor and chronic pain. Visiting Professor: Clinic im Park, Zurich, Switzerland, June 3, 2004 - Invited Presentation.

35. Mechanisms of Forebrain Pain Processing. Plenary Lecture, International Pain Clinic World Society of Pain Clinicians. Tokyo, Japan, July 14, 2004 - Invited Presentation.

36. Mechanisms of DBS for movement disorders and chronic pain. Visiting Professor: FDA Staff College (CDRH), Rockville MD, July 28, 2004 - Invited Presentation.

37. Single neuron analysis of the thalamus and pallidum in patients with dystonia: somatosensory reorganization and dystonia related activity. Visiting Professor at Grand Rounds, Department of Neurosurgery, George Washington University, Washington DC. January 11, 2005 – Invited Presentation.

38. Thalamic neuronal activity related to parkinsonian symptoms of tremor and dystonia is characterized by disordered somatosensory feedback. Symposium on Parkinson’s disease – Basic Mechanisms and Therapies. Cold Spring Harbor Laboratory, Long Island, NY. January 16-18, 2005 – Invited Presentation.

39. Human brain pain-related activity: binary channels, analog channels and memory. 13th Annual Rachidian Society Meeting, Kona, Hawaii. February 27, 2005 – invited presentation.

40. Human brain dystonia-related activity: activity-dependent changes in function, sensori-motor mismatch, and phase lags. 13th Annual Rachidian Society Meeting, Kona, Hawaii. March 3, 2005 – invited presentation.

41. Human Forebrain Pain-related Activity: pathways and networks. Grass Lecturer. The ‘Senior’ Society of Neurological Surgeons. Palo Alto, California. May 22 2005 – plenary presentation.

42. Forebrain Pain-related activity: pathways, networks and neuromodulation. Congress of International Society of Reconstructive Neurosurgery. Seoul, Korea. September 2, 2005 – plenary presentation.

43. ‘Neuronal activity in patients with Essential Tremor’ NIH Consensus Conference on Essential Tremor. Bethesda Maryland, USA, October 20, 2005 – Invited Presentation.

44. ‘Stimulation of the Brain: Deep Brain Stimulation for PD: Targets and Review’ North American Neuromodulation Society. Washington DC November 11, 2005 - Invited

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Plenary Presentation. 45. ‘Human forebrain mechanisms of Dystonia.’ Presentation at ‘The neural control of

abnormal movement.’ April 30 to May 2, 2006, Key Biscayne, FL, A satellite meeting preceeding the Neural Control of Movement Society Meeting – Invited Presentation.

46. ‘Overflow of muscle activation in dystonia explained by sensor-motor mismatch resulting from reorganization of forebrain sensory maps’ NIH-NINDS Grand Neurology Rounds. May 9, 2006, Bethesda MD – Invited Presentation.

47. ‘Forebrain pain related pathways and networks.’ Heller Lecture Series, Faculty of Medicine, Hebrew University, Jerusalem, Israel. March 6, 2007 – invited presentation.

48. ‘Forebrain pain related pathways and networks.’ Symposium Series for the Institute for Computational Neuroscience, Faculty of Medicine, Hebrew University, Jerusalem, Israel. March 8, 2007 – invited presentation.

49. ‘Human forebrain activity related to central pain’ Bienniel meeting of the Asian Society of Steretotactic, Functional, and Computer-assisted Neurosurgery. May 22, 2007. Mount Fuji Resort, Yamanashi, Japan – Invited Presentation.

50. ‘Human pain pathways and networks.’ Brain Science Institute Forum - RIKEN Institute. May 24 2007, Wakoshi, Tokyo, Japan – Invited Presentation.

51. Pain processing in Human S1 Cortex: Traditional and Emerging Perspectives. at symposium on ‘S1 and Pain’. Triennial World Congress of the International Assoc for the Study of Pain. August 18, 2008, Glasgow UK. – Invited Presentation.

52. Forebrain networks mediating pain related activity. Walter E. Dandy Lecture. Johns Hopkins University, Baltimore Maryland. November 20, 2008. – Invited Lecture

53. ‘Distributed cortical processing of thermal and pain sensations in humans.’ John D. Loeser lecturer and Honored Guest, Section on Pain, American Assoc. of Neurologic Surgeons. May 5, 2009, San Diego, California, – Invited Presentation.

54. Pain pathways and networks as the basis for sensory, cognitive and affective dimensions. Special Guest Lecturer 50th Anniversary of Department of Neurosurgery, Korea University, Seoul, Korea. May 30, 2009. – Invited Presentation.

55. Human pain pathways, processors and networks. 6th Ken Casey Visiting Professor, Department of Neurology, University of Michigan, Ann Arbor. September 15, 2009 – Invited Professor.

56. Thalamic discharge patterns as a gate for nociceptive transmission to cortex and cortical binding. Symposium on Discharges and Evoked Potentials in Pain. Biennial World Congress of the International Assoc for the Study of Pain. Sept 2, 2010, Montreal. – Invited Presentation.

57. Plenary Symposium: Chronic pain and anomalous brain physiology. Annual Meeting of the Society for Neuroscience. C Saab, MC Bushnell, A Keller, FA Lenz, RR Llinas. Washington DC, October 2011 – Invited Presentation. .

58. Invasive methods of brain stimulation for the Treatment of pain. at the International Assoc for the Study of Pain Symposium on Transcranial Magnetic stimulation for the treatment of pain. Radcliffe College, Boston. October 8, 2013. – Invited Presentation.

59. Keynote Lecture on Surgery for Movement Disorders: Why does the same small lesion of the thalamus treat all types if tremor? 72nd Annual Meeting of the Japanese Neurosurgical Society. Yokohama,, Japan. October 17, 2013. - Invited Presentation.

60. Special Lecture: Pain Pathways and Networks. 72nd Annual Meeting of the Japanese Neurosurgical Society. Yokohama, Japan. October 17, 2013. - Invited Presentation.

61. IASP Symposium: Labeled lines? Tracking somatotopy of nociceptive input through the central nervous system. at the IASP biennial meeting in Buenos Aires. October 2014, with U Baumgartner, M Fitzgerald. - Invited Presentation.

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62. The Physiology of Essential Tremor. Essential Knowledge Gaps in the Field of Essential Tremor. NINDS: NIH, Bethesda MD. May 11-12, 2015. - Invited Presentation.

63. Human Forebrain Pain systems. Pain Rox Seminar Series, FMRIB University of Oxford. October 18, 2015. - Invited Presentation.

64. The Pathophysiology of Movement Disorders. University of Calgary Neurology Neurosurgery Combined Grand Rounds. Calgary January 28 2016. - Invited Presentation.

65. Thalamic discharge patterns as carriers of pain signals to cortex and mediators of cortical connectivity: the long view. Research Seminars, Hodgkiss Brain Institute. Calgary January 28, 2016. - Invited Presentation.

66. Human CNS mechanisms of Attention to and Fear of Pain. Neuroscience Seminar. NYU ECNU Center, Shangai PRC. April 13, 2016. - Invited Presentation.

67. Possibilities of Research with Recordings of Local Field Potentials through Electrodes implanted for the Investigation of Epilepsy. Neuroscience Seminar. NYU ECNU Center, Shangai PRC. April 13, 2016. - Invited Presentation.

68. Functional Neurosurgery at Johns Hopkins Hospital. Neurosurgical Grand Rounds. Shanghai Huashan Hospital, Fudan University, April 12, 2016. - Invited Presentation.

69. Pathways and Thalamocortical Networks for Pain in the Human Forebrain. Dept of Biomedical Engineering and McGovern Brain Institute, Tsinghua University, Beijing, PRC. April 2016. - Invited Presentation.

70. Pain Pathways and Networks. Institute for Biomedical Sciences of Pain & Institute for Functional Brain Disorders. The Fourth Military Medical University. Xi’an, PRC, April 21 2016. - Invited Presentation.

71. NANS Neural Interfaces 2016 Symposium New stimulation paradigms for pain. with Drs Z. Kiss, D. deRidder, J. Henderson. Baltimore MD. June 27 2016 - Invited Presentation.

72. Pain in the Brain: as studied by Recordings from the Human Brain during Awake Surgeries, NIH Pain SIG, Bethesda, MD. November 10, 2016. - Invited Presentation.

Patents: US Patent 6,589,190 (July 8, 2003). Title of Invention: Quantitative Assessment of Muscle Tone in the Wrist JHUSOM Office of technology licensing no. DM-3434 Name of Lead Inventor: deLateur , B. J. Additional Inventors: Kanderian, S.J., Goldberg, R., Rieflin, K., Whitcomb, L.L., Lenz, F.A.

curriculum vitae frederick arthur lenz emographic … · curriculum vitae _____ frederick arthur...

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