CURRICULUM VITAE

Director, Connective Tissue Biochemistry Laboratory Department of Orthopaedic Surgery

University of California San Diego

Joy Lyons, Nov. 27, 1966 U.S. Citizenship: 967

DAVID AMIEL, Ph.D. Professor of Orthopaedics

School of Medicine

Birthdate: October 25, 1938 Birthplace: Alexandria, Egypt Married: Nancy

1 Education

Institution Degree Year Major Lycee Francais B re accalau ate 1943-1955 Mathematics

lexandria, Egypt

1958-1962 Chem Engineer

russels, Belgium Chimiste Ph.D.

A University of Brussels B.Sc. 1955-1958 Chemistry, Institut Meurice-Chimie Diplome d'Ingenieur B Research and Professional Experience Professor of Orthopaed Department of Orthopaedics ics

nia at San Diego irector, Connect Tiss Biochem La Jolla, California

nia at San Diego irector, Orth Biochem Lab La Jolla, California

tation nia at San Diego

irector, Orth Biochem Lab La Jolla, California

tation nia at San Diego

irector, Orth Biochem Lab La Jolla, California

tation nia at San Diego

uly 1970 to June 1975 La Jolla, California

cs e 197 ton

Seattle, Washington

atories July 1966 to October 1968 Seattle, Washington

July 1992 to present University of CaliforD Associate Professor Department of Orthopaedics July 1986 to June 1992 University of CaliforD Assistant Professor Division of Orthopaedics and Rehabili July 1983 to June 1986 University of CaliforD Specialist in Orthopaedics Division of Orthopaedics and Rehabili July 1975 to June 1983 University of CaliforD Associate Specialist Division of Orthopaedics and Rehabili in Orthopaedics University of CaliforJ Associate in Orthopaedics Department of Orthopaedi November 1968 to Jun 0 University of Washing Chief Chemical Engineer Laucks Testing Labor

Prof. David Amiel

aedics Nov. 1964 to June 1966 University of Washington

eer Laucks Testing Laboratories

aboratories June 1962 to Dec. 1962 Boeing Aerospace Division

iewer for the Follo

Assoc in Orthopaedics Department of Orthop Seattle, Washington Chemical EnginJan. 1963 to October 1964 Seattle, Washington Chemical Engineer Polymers Research L Renton, Washington Rev wing Journals

American Journal Sports Medicine

eering

heumatism

nited Kingdom)

h

onnective Tissue Research

Surgery

search

ce in Sports and Exercise

rtilage, Editorial Board

Tissue Engineering

American Journal of Physiology

Annals of Biomedical Engin

Arthritis and R

Arthroscopy

Bone (ed J Kanis, U

Bone and Mineral

Cell and Tissue Researc

Cells, Tissues, Organs

Clinical Orthopaedics

Comparative Biochemistry

C

Gene Therapy

Journal of Applied Physiology

Journal of Bone and Joint

Journal of Hand Surgery

Journal of Orthopaedic Re

Journal of Rheumatology

Medical Science Monitor

Medicine and Scien

Molecular Therapy

Osteoarthritis and Ca

University Committees

Academic Senate Committee on Academic Personnel (CAP) UCSD 2003-2004

, 1997-present , 2000-2004

iences 1995 lanning, 1996

ine UCSD 1988-1991 ent

Academic Senate Committee on Research (COR), 2000-2001 Academic Senate Health Sci Subcommittee Chairman 1999-2001 Academic Senate Member, Representative Assembly UCSD 1992Academic Senate Orthopaedic Delegate UCSD 1995-1999Academic Senate One-Unit Undergraduate Seminar UCSD 1996 Academic Senate Subcommittee on Research 2002-2003 Ad Hoc Review Committee Academic Personnel UCSD 1993-present Ad Hoc Committee, School of Medicine, for the Future of Basic ScBudget Committee, Vice Chancellor Resource Management and PClinical Affairs Committee, Dept Orthopaedics UCSD 1992-1993 Defense Conversion Committee, School of Medicine UCSD 1993 Electives Committee ISP Reviewer, School of Medicine UCSD 1987-1993 Executive Committee, Dept Surgery, School of MedicExecutive Committee, Dept Orthopaedics, School of Medicine UCSD 1993-pres

Prof. David Amiel

t ent

1993-present esent

CSD 1993-present

2000 1993-present

, 1st Edition Participant 2005 04-2005

mics Rvwr, 1999 993, 1997-1998

D 1989-1992 4-2003

chool of Medicine, La Jolla Stem Cell Initiative Program 2005 School of Medicine Hlth Sci Division of Development, Endowment Presentation 2005

Nominee, Health Sci Faculty Rights and Welfare Committee 2005

Appointments

Faculty, Basic Biomedical Science/Physiology 1996 Faculty, Sam and Rose Stein Inst for Research on Aging UCSD 1992-presenGlycobiology Research and Training Center Member 1998-presInstitute for Biomedical Engineering Committee UCSD 1990-present JCAHO On-Site Survey, Dept Orthopaedics Space Committee UCSD 1995 Little Orthopaedic Club, Dept Orthopaedics UCSD 1995-1996 Long Range Planning Committee Orthopaedic Research UCSD 1990-1993 Orthopaedic Clinical Research Committee, Dept Orthopaedics UCSDOrthopaedic Committee Research Goals and Directions, Chairman, 2001-prOrthopaedic Research Advisory Committee (ORAC), Dept Orthopaedics UOrthopaedic Resident Committee, Dept Orthopaedics, 1999-present Orthopaedic Resident Research Day 2000 Planning Committee 1999-Orthopaedic Space Committee, Dept Orthopaedics UCSDOrthopaedic Surgery Newsletter, Osteochondral Allograft ProgramOrthopaedic Traveling Fellows Co-Host, Japan and ICRS 20Orthopaedic Voluntary Clinical Faculty Committee, 1998 Preclinical Steering Committee, Dept Orthopaedics UCSD 1991 San Diego Institute for Musculoskeletal Regeneration 2005 School of Med Burroughs Wellcome Appl Innovation Awards in Functional GenoSchool of Medicine Introduction to Laboratory Research 1School of Medicine Independent Study Project Committee UCSSchool of Medicine Recruitment and Admissions Committee (RAC) 199School of Medicine Global Space Committee 1996-1999 School of Medicine Subcommittee on Research 1997-present School of Medicine Subcommittee on Research Chairman 1999-2000 S

School of Medicine,

d Research - 1983-2005

rs ation - 1989-1992

cine, Japan 2000-present

Board of Directors Bone and Joint Disease Foundation - 1983-1985 Board of Directors Malcolm and Dorothy Coutts Institute of Joint Reconstruction an Board of DirectoAmerican College of Sports Medicine Found Editorial Board Osteoarthritis and Cartilage - 1992-present Program Committee Orthopaedic Research Society - 1996-1997 Adjunct Faculty Advisor Chiba University School of Medicine, Japan 2000-present Adjunct Faculty Advisor Kyoto Prefectural Univ School of Medi

Prof. David Amiel

edical and Scientific Advisory Board ard/Round Table

steoarthritis Research Society International - 2003-present

ife Member Intl Soc for Hyalu

Diego, 2005

Agency Committees

MClinical Advisory BoArthroCare Corporation - 2001-present Board of Directors O L

ronan Sciences (ISHAS), 2005 Founding Member, Tissue Engineering Center San

Services to Educational and Government Granting

in Functional Genomics Review Committee, 1999

ew Comm

Committee

ittee 1997-2003

ew Committee

ndon, Research Leave Fellowship Committee 1997-present

Scholarships and Honors

Arthritis Society, Canada Grant Review Committee

Katholieke Universiteit Leuven Research Council, Belgium 2004

Medical Research Council, London Grant Review Committee 1997

Burroughs Wellcome Appl Innovation Awards

Natl Institutes of Health, Orthopedics and Musculoskel Study Section NIAMS Grant Revi

Natl Institutes of Health, Osteoarthritis Study Section NIAMS Grant Review

Natl Science Foundation, SBRI Grant, 2003

Orthopaedic Research and Education Foundation Grant Review Comm

Swiss National Science Foundation Grant Review Committee 1998-2003

Univ Calif Discovery Grant Review Committee 2003

U.S. Government Veterans Administration Ad Hoc Revi

Wellcome Trust, Ltd, Lo

Awards

Scholarship from the Belgium Government 1956-1962 Graduated cum laude

967

oc Sports Med), 1983

86

Coauthor of Nicolas Andry Award-winning paper, 1965 Coauthor of Kappa Delta Award-winning paper, 1 Honorary Member Western Orthopaedic Association, 1980 Invited to New York Academy of Sciences, 1981 Award for Excel in Basic Sci Research (Amer Orth S Kappa Delta Award Paper for Outstanding Orthopaedic Research, 1986 Visiting Professor, North Carolina, Chapel Hill 19

Prof. David Amiel

ward for Excel in Basic Sci Research (Amer Orth Soc Sports Med), 1986

mer College Sports Med Citation Award, 1987

ellow, Amer College Sports Medicine, May, 1988-present

isiting Professor, Alberta Heritage Scholar, Univ Calgary, July, 1988

o-Investigator, NIH MERIT Award for Ant Cruciate Ligament, 1989-1999

oauthor, O'Donoghue Award (Amer Orth Soc for Sports Med), 1990

Am Spine Soc: The AcroMed Award for Outstanding Spine Research, 1993

oauthor, Amer Orth Assoc Zimmer Travel Award, 1994

oauthor, So Biomed Engrng Conf First Resident's Award, 1994

oauthor, Orth Res and Educ Found, CH Herndon Residency Res Award, 1995

Coauthor, Marshall Urist Young Investigator Award, 1996

oauthor, Arthroscopy Association of North America Research Award, 1996

oc Intl de Recherche Orthop et de Traumatol (SIROT) Research in Orthopaedics Award, 1999

ociete Francaise d’Arthroscopie, La Baule, France, Best Basic Science Paper Award, 2001.

oauthor, Vernon P. Thompson Award, Western Orthopaedic Association, 2001

oauthor, Vernon P. Thompson & Lloyd W. Taylor Awards, Western Orthopaedic Association, 2002

ristol Myers Excellence in Orthopaedic Rsrch Awd, Orthop Rsrch and Educ Found (OREF), 1996-2002

oauthor, California Orthopaedic Association (COA) OREF Res Award, 2003

oauthor, Esch Award and Best Paper Award, UCSD Orthopaedic Resident Research Day, 2003

oauthor, Smith and Nephew Resident Research Competition Awards, 2004

ife Member, Intl Soc Hyaluronan Sciences, 2005

oauthor, Lloyd W. Taylor Award, Western Orthopaedic Association (WOA), 2003, 2004, 2005, 2006

oauthor, Osteoarth Rsrch Soc Intl (OARSI) Young Investigator Award, 2003 and 2006 Coauthor, Calif Orthopaedic Assoc (COA) DePuy Orthopaedic Research Award, 1997, 2003 and 2008 Coauthor, Western Orthopaedic Association (WOA) Resident Award, 2005 and 2008

A A F V C C N C C C

C S

S C C B C C C L C C

Prof. David Amiel

al So eties

Membership in Profession ci

t 1978-present

-1986

t e Traum tologi

m Coll ge Sp ts Meion 995

resent

t

2. Cartilage Repair Society 1998 23. Intl Cartilage Repair So

. Who's Who in the World, 15 -17 and 20 -24 Editions 1998-2007 07

. Who’s Who in America, 55 -63 Edition 2001-2009

Serving as a Committee Member of Professional Societies

1. American Chemical Society 1962 2. Belgium Chemical Engineers Society 1962 3. Western Connective Tissue Society 1974-presen 4. Orthopaedic Research Society 5. American Society of Biomechanics 1978-1986 6. American Society for Bone and Mineral Research 1979 7. (Fellow 1988) American College of Sports Medicine 1979-present 8. (Honorary Member) Western Orthopaedic Association 1980-present 9. (Invited) The New York Academy of Sciences 1981-2000 10. Who's Who in California 1984 11. SIROT Soc Intl de Recherche Orth e d a e 1989-present 12. Amer Soc for Gravitation and Space Biology 1990-1997 13. The Wound Healing Society 1991-present 14. Gollnick Memorial Lecture Adv Comm, A e or d 1991-present 15. Who's Who in Science and Engineering, 1st-3rd Edit 1992-116. Osteoarthritis Research Society 1992-p17. Institute for Biomedical Engineering 1992-present 18. Who's Who in American Education, 4th Edition 1993 19. Who's Who in the West, 24th and 25th Edition 1993-1995 20. International Society for Matrix Biology 1994-presen21. Capital Campaign, Amer College Sports Medicine 1995 2

ciety (ICRS) 1999-present24. Intl Soc Hyaluronan Sciences (ISHAS), Life Member 2005

th th th th2526. Who's Who in Medicine and Healthcare, 2nd-6th Editions 1999-20

th rd27

ittee to NASA

1991-present

000

Ligament and Tendon Biology. Moderator, Orthop Res Soc Mtng, Anaheim, February 1, 1999

Amer Inst Biol Sci (AIBS) Space Medicine Peer Review Panel Comm Gollnick Memorial Lecture Committee, Amer College Sports Med Editorial Board, Osteoarthritis and Cartilage 1992-present Capital Campaign Committee, Amer College Sports Medicine 1995 Program Committee, Orthopaedic Research Society 1996-1997

Wellcome Trust, Ltd, London, Research Leave Fellowship Committee 1997-1998

Amer Acad Orthopaedic Surgeons, Gene Therapy Panel, Research Agenda Comm 2

Prof. David Amiel

Teaching Commitments

Intl Cart Repair Soc (ICRS) ad hoc Committee Pre-Clinical Models of Cartilage Repair 2005

ICRS (Intl Cart Repair Soc) Organizing Comm, 6th Annl Symposium Jan 9-11, 2006

eeks.

sses to the Navy/Univ orthopaedic research residents and e clinical faculty. February-June.

he molecular basis of disease. Osteoarthritis and other connective tissue disorders. Undergrad Biol 116.

s of connective tissue, calcium metabolism and e stud s, r esidents (incl. Navy and

94

, PhD apan 1996-1998 , PhD

8-2000 0

PhD 99-2001

0-2001 hD

b MD , MD

P D D

MD, Ph an 2004-2006 -2005

HS) 2004-2005 ermany 2005-2009

ost-Doctoral Fellow Yasushi Oshima, MD Kyoto Prefectural Univ, Japan 2003-2007

Winter Quarter: Connective tissue courses to orthopaedic research residents and fellows. Seven w Spring Quarter: Orthopaedic biochemistry clath T Summer Quarter: Series of lectures on biochemi tryconnective tissue genetic disorders to graduat ent esearch fellows and rUCSD) and to the clinical faculty. Five weeks. Orthopaedic Research Residents All year Post-Doctoral Fellow Monica Wiig, MD Uppsala, Sweden 1987-1990 Post-Doctoral Fellow Chandra Nagineni, PhD India 1989-1991 Post-Doctoral Fellow Anna Monosov, PhD Russia, 1992-1994 Post-Doctoral Fellow Makoto Yoshioka, MD, PhD Kyoto Prefectural Univ, Japan 1992-19Post-Doctoral Fellow Yuichi Wada, MD, PhD Chiba University, Japan 1993-1996 Post-Doctoral Fellow Choji Shimizu, MD, PhD Kyoto Prefectural Univ, Japan 1994-1996 Post-Doctoral Fellow Masaki Sonoda MD, PhD Chiba University, Japan 1995-1997 Post-Doctoral Fellow Kenji Takahashi MD Kyoto Prefectural Univ, JPost-Doctoral Fellow Myung Chul Lee, MD Seoul Natl Univ, Korea 1996-1998 Post-Doctoral Fellow Kohei Kobayashi MD, PhD Chiba University, Japan 1997-1999 Post-Doctoral Fellow Kenji Yamada, MD, PhD Nagoya University, Japan 199Post-Doctoral Fellow Hajime Mishima, MD, PhD Tsukuba University, Japan 1998-200Post-Doctoral Fellow Toru Morihara, MD, Kyoto Prefectural Univ, Japan 19Post-Doctoral Fellow Toru Toyoguchi, MD, PhD Chiba University, Japan 1999-2001 Post-Doctoral Fellow Alex Giurea, MD Univ Vienna 2000-2001 Post-Doctoral Fellow Virgil Medlock, MD Univ Texas Southwestern 200Post-Doctoral Fellow Kenji Kobayashi, MD, P Nagoya University, Japan 2000-2002Post-Doctoral Fellow Michael Gustavel, MD Univ Washington, 2001-2002 Post-Doctoral Fellow Takahisa Sasho, MD, PhD Chiba University, Japan 2001-2003 Post-Doctoral Fellow Adrian Obuch, MD Univ Southern Calif 2001-2003 Post-Doctoral Fellow Tsuyoshi Watana e, Nagoya University, Japan 2002-2004 Post-Doctoral Fellow Jeffrey R Cummings Loma Linda Univ 2003-2004 Post-Doctoral Fellow Kevin P Hansen, MD Loma Linda Univ 2003-2004 Post-Doctoral Fellow Sakae Sano, MD, h Chiba University, Japan 2003-2005 Post-Doctoral Fellow Norimasa Takahashi, M Chiba University, Japan 2004-2005 Post-Doctoral Fellow Hirohito Mitsuyama, D Nagoya University, JapPost-Doctoral Fellow Thomas Turgeon, MD Univ Western Ontario, Canada 2004Post-Doctoral Fellow John Locke, MD Uniformed Services Univ (USUPost-Doctoral Fellow Simon Gortz, MD Bayerische J-M Univ, GP

Prof. David Amiel

Kyoto Prefectural Univ, Japan 2005-2007 Post-Doctoral Fellow Nobuy hiba U ity, Japan 2006-2007 Post-Doctoral Fellow Mark J niv Io 06-2007 Post-Doctoral Fellow Ryo M hiba U ity, Japan 2007-2008 Post-Doctoral Fellow Sean W Un ago, 2007-2008 Post-Doctoral Fellow Bryan C Irvi 8-2009 Ph.D. Thesis Defense Comm

Ph

., P D ary

anda K, PhD 2001-2002 2004 2005

Zak, Beverly, PhD 2003-2006 evin B, PhD 2004-2005 h R, PhD 2005-2007

2006-2007

Chang, Douglas, MD, PhD 1999 , MD, PhD 2006

edical Students Introduction to Laboratory Research SM248

Undergraduate Students 199 research ndergraduate Students Biology 116. The Molecular Basis of Disease

Underg istry of Connective Tissue

. Physical and Chemical Properties of the Polyurethane Foams, Chemical Engineer Thesis,

. Akeson, W.H., Amiel, D. and LaViolette, D.: The Connective Tissue Response to Immobility: A

83-197, 1967. (Nicholas Andry Award-winning Paper).

Post-Doctoral Fellow Atsuo Inoue, MDasu Ochiai, MD C nivers Ritter, MD U wa, 20urata, MD, PhD C niversC Tracy, MD N iv Chic Leek, MD U ne, 200

ittees Lee, Ann A, PhD 1996 Chen, Albert C, PhD 1997 Gallagher, Ann Marie, PhD 1997 Ahsan, Tabassum, D 1998 Chang, Douglas G, MD, PhD 1999 DiMicco, Michael A h 2001 Joanne Archambault, PhD 2001 U CalgKurtis-Micou, Melissa S, PhD 999-2001 Herrmann, Keith L, PhD 2000-2002 Williamson, AmBae, Won C, PhD 2002-Temple-Wong, Michele, PhD 2003-

McGowan, KGratz, KennetWilliams, Gregory M, PhD

M.D., Ph.D. Thesis Defense Committees Zak, Beverly Medical Students Surgery 296-16 ISPMedical Students Orthopaedics 299 ISP MMedical Students Foreign Ferdinand Wagner, Universität Regensburg SOM, Germany 2004-2005

UUndergraduate Students AMES 281

raduate Students Revelle 90. Biochem Distinguished Lecturer School of Medicine. Tissue Engineering of Articular Cartilage. May 20, 1999

PUBLICATIONS

1University of Brussels, Belgium, 1962.

2Study of the Chondroitin-4 and -6 Sulfate and Dermatan Sulfate Changes in Periarticular Connective Tissue of Control and Immobilized Knees of Dogs. Clin Orthop 51:1

Prof. David Amiel

968

. Akeson, W.H., Amiel, D., LaViolette, D. and Secrist, D.: The Connective Tissue Response to

5. iyashita, C., Taylor, T., LaViolette, D. and Amiel, D.: Experimental Arthroplasty of

the Canine Hip: Extracellular Matrix Composition in Cup Arthroplasty. J Bone Joint Surg

6. .: Cartilage Destruction in

Experimentally Produced Staphylococcus Aureus Joint Infections: In Vivo Study. Surg Forum

7. and Daniel, D.: The Connective Tissue

Response to Immobility: Biochemical Changes in Periarticular Connective Tissue of the

8. s, R.D., Matthews, J.V. and Amiel, D.: Potential

Application of Graphite Fiber and Methylmethacrylate Resin Composites as Internal Fixation

9. Biochemical Changes

in the Periarticular Connective Tissue During Contracture Development in the Immobilized Rabbit

10. miel, D.:

Quantitative Histological Evaluation of Early Fracture Healing of Cortical Bones Immobilized by

1. Woo, S.L-Y, Matthews, J.V., Akeson, W.H., Amiel, D. and Convery, F.R.: Connective Tissue

5.

12. marthrosis

ol on the

14. d Amiel, D.: rtical Bone Atrophy Secondary to Fixation with Plates with Large

Differences in Bending Stiffness. J Bone Joint Surg 58-A(2):190-195, 1976.

15. less Steel and Composite Plates in the Healing of Diaphyseal Osteo-

tomies of the Dog Radius: Report on a Short Term Study. Orthop Clin North Am

6. Akeson, W.H., Woo, S.L-Y, Rutherford, L., Coutts, R.D., Gonsalves, M. and Amiel, D.: The

3. Akeson, WH, Miyashita, C, Taylor, T, Amiel, D: Experimental Arthroplasty of the Canine Hip: Extracellular Matrix Composition in Non-Interpositional Arthroplasty. J Surg Res 8:26-40, l

4Immobility: An Accelerated Aging Response? Exp Gerontol 3:289-30l, 1968.

Akeson, W.H., M

51A(1):149-164, 1969. (Kappa Delta Award-winning Paper.)

Daniel, D., Boyer, J., Green, S., Amiel, D. and Akeson, W.H

479-481, 1973.

Akeson, W.H., Woo, S.L-Y, Amiel, D., Coutts, R.D.

Immobilized Rabbit Knee. Clin Orthop 93:356-362, 1973.

Woo, S.L-Y, Akeson, W.H., Levenetz, B.L., Coutt

Plates. J Biomed Mater Res 8(5): 321-338, 1974.

Akeson, W.H., Woo, S.L-Y, Amiel, D. and Matthews, J.: Biomechanical and

Knee. Connect Tissue Res 2(4):315-323, 1974.

Akeson, W.H., Woo, S.L-Y, Coutts, R.D., Matthews, J.V., Gonsalves, M. and A

Stainless Steel and Composite Plates. Calcif Tissue Res 19:27-37, 1975.

1Response to Immobility: Correlative Study of Biomechanical and Biochemical Measurements of Normal and Immobilized Rabbit Knees. Arthritis Rheum 18(3):257-264, 197

Convery, F.R., Woo, S.L-Y, Akeson, W.H., Amiel, D. and Malcom, L.: Experimental Hein the Knee of the Mature Canine. Arthritis Rheum 19(1):59-67, 1976.

13. Akeson, W.H., Woo, S.L-Y, Amiel, D., Doty, D. and Rutherford, L.: Value of 17 ßoestradi

Prevention of Contracture Formation. Ann Rheum Dis 35:429-436, 1976. Woo, S.L-Y, Akeson, W.H., Coutts, R.D., Rutherford, L., Doty, D., Jemmott, G. an A Comparison of Co

Coutts, R.D., Akeson, W.H., Woo, S.L-Y, Matthews, J.V., Gonsalves, M. and Amiel, D.: Comparison of Stain

7(1):223-229, 1976.

1Effects of Rigidity of Internal Fixation Plates on Long Bone Remodeling. Acta Orthop Scand 47:241-249, 1976.

Prof. David Amiel

17. Boyer, J.: Lavage of Septic Joints in Rabbits: Effects of Chondrolysis. J Bone Joint Surg 58-A(3):393-395, 1976.

18. n

9. Akeson, W.H., Woo, S.L-Y, Amiel, D. and Doty, D.: Rapid Recovery from Contracture in

0. Akeson, W.H., Amiel, D., Mechanic, G.L., Woo, S.L-Y, Harwood, F.L. and Hamer, M.L.:

ilized

3. Fronek, K., Bloor, C.M., Amiel, D. and Chvapil, M.: Effect of Long-Term Sympathectomy on

24. ible

onnective Tissue of the Rabbit Knee after Nine Weeks of Immobilization. Biochem of Normal and Path Conn Tissues. VIth Colloquium of

25.

6. Amiel, D., Woo, S.L-Y and Akeson, W.H.: Studies of the Biomechanical Joint Stiffness and

t

1979. 7. Amiel, D., Akeson, W.H., Harwood, F.L. and Mechanic, G.L.: The Effect of Immobilization on

es

, 1980.

Daniel, D., Akeson, W.H., Amiel, D., Ryder, M. and

Boyer, J., Daniel, D., Akeson, W.H., Amiel, D. and Ryder, M.: Effect of Salicylate Therapy oCartilage Destruction in Experimental Pyarthrosis. Clin Orthop 126:302-304, 1977.

1Rabbit Hindlimb. Clin Orthop 122:359-365, 1977.

2Collagen Cross-Linking Alterations in Joint Contractures: Changes in the Reducible Cross-Links in Periarticular Connective Tissue Collagen after Nine Weeks of Immobilization. Conn Tissue Res 5:15-19, 1977.

21. Convery, F.R., Minteer, M.A., Amiel, D. and Connett, K.L.: Polyarticular Disability:

A Functional Assessment. Arch Phys Med Rehab 58:494-498, 1977. 22. Amiel, D., Akeson, W.H., Harwood, F.L., Schmidt, D.A. and Mechanic, G.L.: Effect of Low

Dosage Schedule of D-Penicillamine on Collagen Cross-Linking in a Nine-Week ImmobRabbit Knee. Conn Tissue Res 5:179-183, 1977.

2the Arterial Wall in Rabbits and Rats. Exp Mol Pathol 28:279-289, 1978.

Amiel, D., Akeson, W.H. and Mechanic, G.: Quantitative Determinations of Stable ReducCross-Link Formation in Periarticular C

the Eur Conn Tissue, France, 305-306, 1978.

Woo, S.L-Y, Kuei, S.C., Gomez, M.A., Winters, J.M., Amiel, D. and Akeson, W.H.: The Effect of Immobilization and Exercise on the Strength Characteristics of Bone-Medial Collateral Ligament-Bone Complex. 1979 Amer Soc of Mech Engineers, Biomech Sym-posium, AMD, 32:67-70, June, 1979.

2Biochemical Changes in Connective Tissue during the Formation and Development of a JoinContracture. Digest of Combined Meeting of 12th Int'l Conf. on Medical and Biological Engineering, and 5th Int'l Conf on Medical Physics. Jerusalem, Part 10, August,

2the Types of Collagen Synthesized in Periarticular Connective Tissue. Conn Tissue R8:27-32, 1980.

28. Woo, S.L-Y, Ritter, M.A., Amiel, D., Sanders, T.M., Gomez, M.A., Garfin, S.W. and Akeson,

W.H.: The Biomechanical and Biochemical Properties of Swine Tendons - Long Term Effects of Execise on the Digital Extensors. Conn Tissue Res 7:177-183

29. Akeson, W.H., Amiel, D. and Woo, S.L-Y: Immobility Effects on Synovial Joints: The

Pathomechanics of Joint Contracture. Biorheology 17:95-110, 1980.

Prof. David Amiel

arolina, 105-114, 1980.

Flexor

3. Woo, S.L-Y, Kuei, S.C., Amiel, D., Gomez, M.A., Hayes, W.C., White, F. and Akeson, W.H.:

4. Gelberman, R.H., Amiel, D., Gonsalves, M., Woo, S.L-Y and Akeson, W.H.: The Influence of

,

-

o CA 153-161, 1981.

al

op Scand 52:615-622, 1981.

38. tion on Healing Canine Flexor Tendons. J Hand Surg 7(2):

170-175, 1982.

39. l Correlation. Acta

Orthop Scand 53:325-332, 1982.

n Immobilization. Clin Orthop 172: 265-270, 1983.

l d

11(6):379-389, 1983. (Basic Science Award Paper.)

30. Akeson, W.H., Amiel, D. and Woo, S.L-Y: Biological and Biochemical Consideration of JointContracture. Resources for Basic Science Educators - III. Amer Academy of Orth Surg, Comm on Basic Sciences, Hilton Head South C

31. Gelberman, R.H., Amiel, D., Rudolph, R.M. and Vance, R.M.: Dupuytren's Contracture - An

Electron Microscopic, Biochemical and Clinical Correlative Study. J Bone Joint Surg 62-A(3):425-432, 1980.

32. Woo, S.L-Y, Gomez, M.A., Amiel, D. Ritter, M.A., Gelberman, R.H. and Akeson, W.H.: The

Effects of Exercise on the Biomechanical and Biochemical Properties of Swine Digital Tendons. J Biomed Eng 103(1):51-56, 1981.

3The Effect of Prolonged Physical Training on the Properties of Long Bone - A Study of Wolff's Law. J Bone Joint Surg 63-A:780-787, 1981.

3Protected Passive Mobilization on the Healing of Flexor Tendons: A Biochemical and Microangiographic Study. The Hand (British Society for Surgery of the Hand) 13(2):120-1281981.

35. Akeson, W.H., Amiel, D. and Woo, S.L-Y: Cartilage Architecture: Its Functional Relevance

IV Resources for Basic Science Educators, Amer Acad of Orth Surg, Comm. on Basic Sciences, San Dieg

36. Woo, S.L-Y, Gelberman, R.H., Cobb, N.G., Amiel, D., Lothringer, K. and Akeson, W.H.: The

Importance of Controlled Passive Mobilization on Flexor Tendon Healing: A BiomechanicStudy. Acta Orth

37. Gershuni, D., Amiel, D., Gonsalves, M. and Akeson, W.H.: The Biochemical Response of

Rabbit Articular Cartilage Matrix to an Induced Talcum Synovitis. Acta Orthop Scand 52:599-603, 1981.

Gelberman, R.H., Woo, S.L-Y, Lothringer, K., Akeson, W.H. and Amiel, D.: Effects of EarlyIntermittent Passive Mobiliza

Amiel, D., Woo, S.L-Y, Harwood, F.L. and Akeson, W.H.: The Effect of Immobilization onCollagen Turnover in Connective Tissue: A Biochemical-Biomechanica

40. Coutts, R.D., Woo, S.L-Y, Boyer, J., Doty, D. Gonsalves, M., Amiel, D. and Akeson, W.H.: The Effect of Delayed Internal Fixation on Healing of the Osteotomized Dog Radius. Clin Orthop 163:254-260, 1982.

41. Amiel, D., Akeson, W.H., Harwood, F.L. and Frank, C.B.: Stress Deprivation Effect on

Metabolic Turnover of the Medial Collateral Ligament Collagen: A Comparison betweeNine- and 12-Week

42. Frank, C.B., Woo, S.L-Y, Amiel, D., Harwood, F.L., Gomez, M. and Akeson, W.H.: Media

Collateral Ligament Healing. A Multidisciplinary Assessment in Rabbits. Am J Sports Me

Prof. David Amiel

43. Ligament of the Knee - A Morphological and Biochemical Assessment in Rabbits. Acta Orthop Scand

4. Amiel, D., Frank, C.B., Harwood, F.L., Fronek, J. and Akeson, W.H.: Tendons and Liga-

45. and Akeson, W.H.: Technical Aspects of

Perichondrial Grafting in the Rabbit. Eur Surg Res 16(5): 322-328, 1984.

46. on. Clin Orthop 185:113-125, 1984.

al and Biochemical Assessment. J Orth Res 2(4):425-431, 1984.

48. nd

Consensus, New York City, May, l984.

49. Akeson, W.H.: Value of Hyaluronic Acid in the Prevention of Contracture Formation. Clin Orthop 196:15-25, 1985.

50. rtilage Defects: A Morpho-

logical and Biochemical Assessment in Rabbits. J Bone Joint Surg 67A:911-920, 1985.

51.

52. Amiel, D., Harwood, F.L., Abel, M. and Akeson, W.H.: Collagen Types in Neo-Cartilage Tissue Resulting from Rib Perichondrial Graft in an Articular Defect - A Rapid Semi-Quantitative Methodology. Coll Relat Res 5(4): 337-347, 1985.

53. Amiel, D., R.D. Coutts and W.H. Akeson: Perichondrial Autografts: Potential for Biological

Resurfacing? Invited paper by 1st Atlantic Congress on the Future of Collagen and Other Connective Tissue Components as Biomaterials. Lyon, France, 155-164, September, 1985.

Frank, C.B., Amiel, D. and Akeson, W.H.: Healing of the Medial Collateral

54:917-923, 1983.

4ments: A Morphological and Biochemical Comparison. J Orth Res 1(3):257-265, 1984.

Coutts, R.D., Amiel, D., Woo, S.L-Y, Woo, Y-K

Frank, C.B., Akeson, W.H., Woo, S.L-Y, Amiel, D. and Coutts, R.D.: Physiology and Therapeutic Value of Passive Joint Moti

47. Coutts, R.D., Amiel, D., Harwood, F.L., Bradley, G. and Akeson, W.H.: Characterization of

Arthroplasty Tissue after 14 Years Post-Cup Arthroplasty: A Morphologic

Akeson, W.H., Amiel, D., Woo, S.L-Y. and Garfin, S.R.: Immobilization Versus Continuous Passive Motion. Proc. of Bristol Meyers-OREF Workshop on Fracture Repair Conflicts a

Amiel, D., Frey, C., Woo, S.L-Y, Harwood, F. and

Amiel, D., Coutts, R.D., Abel, M., Stewart, W., Harwood, F., and Akeson, W.H.: Rib Perichondrial Grafts for the Repair of Full-Thickness Articular Ca

Frank, C.B., Amiel, D., Woo, S. L-Y. and Akeson, W.H.: Normal Ligament Properties and Ligament Healing. Clin Orthop 196:15-25, 1985.

Dr. David Amiel

20

54. Harwood, F.L. and Amiel, D.: Semiquantitative HPLC Analysis of Types I and III Collagen in Soft Tissues. LC Magazine 4(2):122-126, 1986.

55. Amiel, D., Abel, M.F., Kleiner, J.B., and Akeson, W.H.: Synovial Fluid Nutrient Delivery in the

Diarthrial Joint: An Analysis of Rabbit Knee Ligaments. J Orth Res 4:90-95, 1986. 56. Gelberman, R.H., Manske, P.R., Akeson, W.H., Woo, S.L-Y., Lundborg, G. and Amiel, D.: Flexor

Tendon Repair. J Orth Res 4:119-128, March, 1986. (E. W. Lanier Kappa Delta Award for Outstanding Orthopaedic Research)

57. Amiel, D., Kleiner, J.B., Coutts, R.D., Harwood, F.L. and Akeson, W.H.: The Early Course of Rib

Perichondrial Implants for Coverage of Articular Defects: A Morphological and Biochemical Assessment. Annual Mtng of Arthroscopy Assoc of North America, San Francisco, March 20-23, 1986.

58. Amiel, D., Kleiner, J.B., Roux, R.D., Harwood, F.L. and Akeson, W.H.: The Phenomenon of

"Ligamentization": Anterior Cruciate Ligament (ACL) Reconstruction with Autogenous Patellar Tendon (PT). J Orth Res 4(2):162-172, 1986.

59. Amiel, D., Kleiner, J.B. and Akeson, W.H.: The Natural History of the Anterior Cruciate Ligament

Autograft of Patellar Tendon Origin. Amer Orth Soc for Sports Med, Amer J Sports Med 14(6):449-462, 1986. (Basic Science Excellence in Research Award)

60. Amiel, D., Akeson, W.H., Renzoni, S., Harwood, F. and Abel, M.: Nutrition of Cruciate Ligament

Reconstruction by Diffusion: Collagen Synthesis Studied in Rabbits. Acta Orthop Scand 57:201-203, 1986.

61. Kleiner, J.B., Amiel, D., Roux, R.D. and Akeson, W.H.: The Origin of Replacement Cells for the

Anterior Cruciate Ligament Autograft. J Orthop Res 4(4):466-474, 1986.

62. Amiel, D., Frank, C.B., Harwood, F.L., Akeson, W.H. and Kleiner, J.B.: Collagen Alteration in Medial Collateral Ligament Healing in a Rabbit Model. Connect Tissue Res 16:357-366, 1987.

63. Akeson, W.H., Amiel, D., Abel, M.F., Garfin, S.R. and Woo, S.L-Y.: Effects of Immobilization on

Joints. Pathophysiology of Joint Contractures and Their Correction. Clin Orthop 219:28-37, 1987. 64. Amiel, D.: Biochemistry of Connective Tissue. Proceedings of West Coast Orthopaedic Review

Course, May, 1988. 65. Harper, J., Amiel, D. and Harper, E.: Collagenase Production by Rabbit Ligaments and Tendon.

Connect Tissue Res 17:253-259, 1988. 66. Amiel, D., Coutts, R.D.C., Harwood, F.L., Ishizue, K.K. and Kleiner, J.B.: The Chondrogenesis of

Rib Perichondrial Grafts for Repair of Full Thickness Articular Cartilage Defects in a Rabbit Model: A One Year Postoperative Assessment. Connect Tiss Res 18:27-39, 1988.

67. Kleiner, J.B., Amiel, D., Harwood, F.L. and Akeson, W.H.: Metabolic, Histologic and

Vascular Assessment of Anterior Cruciate Ligament Reconstruction During the Early Post Operative Period. Zimmer's Trav Res Fellowship, AOA Mtng, South Carolina, 1988.

Dr. David Amiel

21

8. Gomez, M.A., Woo, S.L-Y., Inoue, M., Amiel, D., Harwood, F.L. and Kitabayashi, L.: Medial

lar

0. Amiel, D., Ishizue, K.K., Harwood, F.L., Kitabayashi, L. and Akeson, W.H.: Injury of the Anterior

,

.:

3. Amiel, D., Harwood, F.L., Hoover, J.A. and Meyers, M.: A Histological and Biochemical Assessment

ve

5. Inoue, M., Woo, S.L-Y., Gomez, M.A., Amiel, D., Ohland, K.J. and Kitabayashi, L.R.: Effects of

6. Wiig, Monica E., Amiel, D., VandeBerg, J., Kitabayashi, L. and Harwood, F.L.: The Early Effect of

n

th

8. Ishizue, K.K., Amiel, D., Lyon, R.M. and Woo, S.L-Y.: Acute Hemarthrosis: A Histological,

9. Billings, E., Jr., von Schroeder, H.P., Mai, M.T., Aratow, M., Amiel, D., Woo, S.L-Y. and Coutts, R.D.:

-

e

2. Gelberman, R.H., Siegel, D.B., Woo, S.L-Y., Amiel, D., Takai, S., and Lee, D.: Healing of Digital

6Collateral Ligament Healing Subsequent to Different Treatment Regimens. J Appl Physiology 66(1):245-252, 1989.

69. Kleiner, J.B., Amiel, D., Harwood, F.L. and Akeson, W.H.: Early Histologic, Metabolic, and Vascu

Assessment of Anterior Cruciate Ligament Autografts. J Orthop Res 7(2):235-242, 1989.

7Cruciate Ligament: The Role of Collagenase in Ligament Degeneration. J Orthop Res 7(4):486-4931989.

71. Amiel, D., Ishizue, K., Billings, E., Jr., Wiig, M., Gelberman, R., VandeBerg, J., and Akeson, W.H

Hyaluronan in Flexor Tendon Repair. J Hand Surg 14A(5):837-844, 1989. 72. Harper, J., Amiel, D. and Harper, E.: Collagenases from Periarticular Ligaments and Tendon:

Enzyme Levels During the Development of Joint Contracture. Matrix 9(3):200-205, 1989.

7of the Cartilage Matrix Obtained from In Vitro Storage of Osteochondral Allografts. Connect TissueRes 23:89-99, 1989.

74. Amiel, D., Foulk, R.A., Harwood, F.L. and Akeson, W.H.: Quantitative Assessment by Competiti

ELISA of Fibronectin (Fn) in Tendons and Ligaments. Matrix 9(6)421-427, 1989.

7Surgical Treatment and Immobilization on the Healing of the Medial Collateral Ligament: A Long Term Multidisciplinary Study. Connect Tissue Res 25:13-26, 1990.

7High Molecular Weight Hyaluronan (Hyaluronic Acid) on Anterior Cruciate Ligament Healing: AExperimental Study in Rabbits. J Orthop Res 8:(3):425-434, 1990.

77. Gelberman, R.H., Woo, S.L-Y., Amiel, D., Horibe, S. and Lee, D.: Influences of Flexor Shea

Continuity and Early Motion on Tendon Healing in Dogs. J Hand Surg 15A(1)69-77, 1990.

7Biochemical and Biomechanical Correlation of Early Effects on the Anterior Cruciate Ligament in a Rabbit Model. J Orthop Res 8:(4)548-554, 1990.

7 Cartilage Resurfacing of the Rabbit Knee: The Use of an Allogeneic Demineralized Bone Matrix Autogeneic Perichondrium Composite Implant. Acta Orthop 61(3):201-206, 1990.

80. Amiel, D., Billings, E., Jr. and Harwood, F.L.: Collagenase Activity in Anterior Cruciate Ligament

(ACL): The Protective Role of the Synovial Sheath. J Appl Phys 69(3):902-906, 1990. 81. Wayne, J.S., Amiel, D., Kwan, M.K., Woo, S.L-Y., Fierer, A. and Meyers, M.H.: Long Term Storag

Effects on Canine Osteochondral Allografts. Acta Orthop Scand 61(6):539-545, 1990.

8Flexor Tendons: Importance of the Interval from Injury to Repair. A Biomechanical, Biochemical and Morphological Study in Dogs. J Bone Joint Surg 73(A):66-75, 1991.

Dr. David Amiel

22

aments 2, 1991

ies

Maturation Study in the Rabbit. J Gerontol 46(4):B159-165, 1991.

86. rwood, F.L. and Siegel, D.: Fibronectin in Healing Flexor Tendons Subjected to Immobilization or Early Controlled Passive Motion. Matrix 11(3): 184-189, 1991.

87. nd

cts l Collateral Ligaments. Am J Sports Med 19(4):347-354,

1991 Winner of 1990 O'Donoghue Sports Injury Research Award.

89. 91, 1991.

ces

Invest Radiol 27(1):84-90, 1992.

92. nd Kwan, M.K.: Rib Perichondrial Autografts in Full-Thickness Articular Cartilage Defects in Rabbits. Clin Orthop 275:263-273, 1992.

94. Surg 17A:551-558, 1992.

ced Osteochondral Defects in Horses. J Vet Res 53(6):1038-1047, 1992.

96. its ):257-261, 1992.

83. von Schroeder, H.P., Kwan, M.K., Amiel, D. and Coutts, R.D.: The Use of Polylactic Acid Matrix and

Periosteal Grafts for the Reconstruction of Rabbit Knee Articular Defects. J Biomed Mater Res 25(3):329-339, 1991.

84. Wiig, M.E., Amiel, D., Ivarsson, M., Nagineni C, Wallace CD and Arfors, K-E.: Type I Pro-collagen

mRNA Levels in Normal and Early Healing of the Medial Collateral and Anterior Cruciate Ligin Rabbits: An In Situ Hybridization Study. J Orthop Res 9(3):374-38

85. Amiel, D., Kuiper, S.D., Wallace, C.D., Harwood, F.L. and VandeBerg, J.S.: Age-Related Propert

of Medial Collateral Ligament and Anterior Cruciate Ligament: A Morphologic and Collagen

Amiel, D., Gelberman, R., Ha

Gelberman, R.H., Steinberg, D. and Amiel, D.: Fibroblast Chemotaxis After Tendon Repair. J HaSurg 16A(4):686-693, 1991.

88. Gomez, M.A., Woo, S.L-Y., Amiel, D., Harwood, F.L., Kitabayashi, L. and Matyas, J.R.: The Effe

of Increased Tension on Healing Media

Wallace, C.D. and Amiel, D.: Vascular Assessment of the Periarticular Structures of the RabbitKnee. J Orthop Res 9:787-7

90. Lyon, R., Akeson, W.H., Amiel, D., Woo, S.L-Y. and Kitabayashi, L.: Ultrastructural Differen

Between the Cells of the Medial Collateral Ligament and the Anterior Cruciate Ligament. Clin Orthop 272:279-286, 1991.

91. Ho, C., Cervilla, V., Kjellin, I., Haghigi, P., Amiel, D., Trudell, D. and Resnick, D.: Magnetic

Resonance Imaging in Assessing Cartilage Changes in Experimental Osteoarthritis of the Knee.

Coutts, R.D., Woo, S.L-Y., Amiel, D., von Schroeder, H.P. a

93. Harwood, F.L., Amiel, D.: Differential Metabolic Responses of Periarticular Ligaments and Tendon

to Joint Immobilization. J Appl Phys 14:1687-1691, 1992.

Gelberman, R.H., Amiel, D. and Harwood, F.L.: Genetic Expression for Type I Pro-Collagen in the Early Stages of Flexor Tendon Healing. J Hand

95. Vachon, A.M., McIlwraith, C.W., Powers, B.E., McFadden, P.R. and Amiel, D.: Morphologic and

Biochemical Study of Sternal Cartilage Autografts for Resurfacing Indu

Harper, J., Amiel, D. and Harper,E.: Inhibitors of Collagenase in Ligaments and Tendons of RabbImmobilized for 4 Weeks. Connect Tissue Res 28(4

Dr. David Amiel

23

he Cell

nd Medial Collateral Ligaments of Human and Rabbit. J Orthop Res 10(4):596-599, 1992.

99. g 4A(8):1207-1216, 1992.

J Plast Reconstr Surg Hand Surg 26(3):257-264, 1992.

01. Lane, J.G., McFadden, P., Bowden, K. and Amiel, D.: The Ligamentization Process: A 4-Year Case 53, 1993.

102. 3:49-55, 1993

mic Mice. Cancer Res (53):4890-4895, 1993.

nect Tissue Res 30:215-224, 1994.

105. M.: n Expression by Human Articular Chondrocytes. Arthritis Rheum 37:537-544, 1994.

2-165, 1994.

107. 94.

., and air

in Horses. Am J Vet Res 55(8):1158-1167, 1994.

ript Award. Spine 19(16):1809-1814, 1994.

110. uciate Ligament of the Rabbit Knee. Iowa Orthop J 14:134-140, 1994.

97. Nagineni, C.N., Amiel, D., Green, M.H., Berchuck, M. and Akeson, W.H.: Characterization of tIntrinsic Properties of the Anterior Cruciate and Medial Collateral Ligament Cells: An In VitroCulture Study. J Orthop Res 10(4):465-475, 1992.

98. Gesink, D.S., Pacheco, H.O., Kuiper, S., Schreck, P.J., Amiel, D., Akeson, W.H. and Woods,

V.L., Jr.: Immunohistochemical Localization of ß1 Integrins in Anterior Cruciate a

Gelberman, R.H., Chu, C.R., Williams, C.S., Seiler, J.G. III, and Amiel, D.: Angiogenesis in HealinAutogenous Flexor Tendon Grafts. J Bone Joint Surg 7

100. Gelberman, R.G., Seiler, J.G. III, Rosenberg, A.E., Heyman, P. and Amiel, D.: Intercalary Flexor

Tendon Grafts: A Morphological Study of Intrasynovial and Extrasynovial Donor Tendons. Scand

1

Study Following ACL Reconstruction with a Semitendinosis Graft. Arthroscopy 9(2):149-1

Amiel, D. and Nimni, M.E.: The Collagen in Normal Ligaments. Iowa Orthop J 1 103. Berlin O., Samid D., Donthineni-Rao, R., Akeson, W.H., Amiel, D. and Woods, V.L., Jr.:

Development of a Novel Spontaneous Metastasis Model of Human Osteosarcoma Transplanted Orthotopically into Bone of Athy

104. Geiger, M.H., Green, M.H., Monosov, A.Z., Akeson, W.H. and Amiel, D.: An In Vitro Assay of

Anterior Cruciate Ligament (ACL) and Medial Collateral Ligament (MCL) Cell Migration. Con

Woods, V.L., Jr., Schreck, P.J., Gesink, D.S., Pacheco, H.O., Amiel, D., Akeson, W.H., and Lotz, Integri

106. Chu, C.R., Monosov, A.Z., Coutts, R.D. and Amiel, D.: Attachment and Survival of Perichondrocytes

in a Porous Polylactic Acid (PLA) Matrix: An In Vitro Study. J Long-Term Eff Med Imp 16

Ark J.W., Gelberman, R.H., Abrahamsson, S-O., Seiler, J.G. III and Amiel, D.: Cellular Survival and Proliferation in Autogenous Flexor Tendon Grafts. J Hand Surg 19A(2): 249-258, 19

108. Howard, R.D., McIlwraith, C.W., Trotter, G.W., Powers, B.E., McFadden, P.R., Harwood, F.L

Amiel, D.: Long-Term Fate and Effects of Exercise on Sternal Cartilage Autografts Used for Repof Large Osteochondral Defects

109. Abitbol, J.J., Lincoln, T.L., Lind, B.I., Amiel, D., Akeson, W.H. and Garfin, S.R.: Preventing

Postlaminectomy Adhesion: A New Experimental Model. NASS/AcroMed Manusc

Amiel, D., Wallace, C.D. and Harwood, F.L.: The Effects of Immobilization on the Maturation of theAnterior Cr

111. Abrahamsson, S-O, Gelberman, R.H., Amiel, D., Winterton, P. and Harwood, F.L.: Autogenous

Flexor Tendon Grafts: Fibroblast Activity and Matrix Remodeling in Dogs. J Orthop Res 13(1):58-66, 1995.

Dr. David Amiel

24

112. grin Display Increases in the Wounded Rabbit Medial Collateral Ligament but not the Wounded Anterior Cruciate

113. D., Nagineni, C.N., Choi, S.H. and Lee, J.: Intrinsic Properties of ACL and MCL Cells and

Their Responses to Growth Factors. Med Sci Sports Exerc 27(6):844-851, 1995.

114. Orthop Res 13:435-441,

1995.

115.

cid

d

of Stress-Deprived Rabbit Anterior Cruciate and Medial Collateral Ligaments. J Orthop Res 13:594-601, 1995.

118. miel, D. and Convery, F.R.: Effect of Tissue Culture Storage on the In Vivo Survival of Canine Osteochondral Allografts. J Orthop Res 13:562-

119. ticular Cartilage. Invited manuscript,

Current Opinion in Orthopaedics 6(VI):52-60, 1995.

120. in Biodegradable Polylactic Acid Polymer Matrices. Winner, First Resident's Award, Biomed Engrng Conf,

121. Hacker, S.A.: Characterization of a Model of

Osteoarthritis in the Rabbit Knee. Osteoarthritis and Cartilage, 4(2):87-98, 1996.

122. nd Their Responses to Growth Factors (bFGF and TGF-ß): An In Vitro Cell Culture

Study. J Orthop Sci 1(2):157-168, 1996.

123. osov, A.Z: Long-Term Survival of Chondrocytes in an Osteochondral Articular Cartilage Allograft. J Bone Joint Surg 78A(7):1082-

24. Sung, K-L.P., Whittemore, D.E., Yang, L., Amiel, D. and Akeson, W.H.: Signal Pathways and

Schreck, P.J., Kitabayashi, L.R., Amiel, D., Akeson, W.H. and Woods, V.L. Jr.: Inte

Ligament. J Orthop Res 13(2):174-183, 1995.

Amiel,

Lee, J., Green, M.H. and Amiel, D.: Synergistic Effect of Growth Factors on Cell Outgrowth fromExplants of Rabbit Anterior Cruciate and Medial Collateral Ligaments. J

Amiel, D., Harwood, F.L., Gelberman, R.H., Chu, C.R., Seiler, J.G. III and Abrahamsson, S.: Autogenous Intrasynovial and Extrasynovial Tendon Grafts: An Experimental Study of Pro αI(I)Collagen mRNA Expression in Dogs. J Orthop Res 13:459-463, 1995.

116. Chu, C.R., Coutts, R.D., Yoshioka, M., Harwood, F.L., Monosov, A.Z. and Amiel, D.: Articular

Cartilage Repair Using Allogeneic Perichondrocyte Seeded Biodegradable Porous Polylactic A(PLA): A Tissue Engineering Study. Winner, AOA-Zimmer Travel Awards Competition for Orthopedic Residents, 1994. J Biomed Mater Res, 29(9)1147-1154, 1995

117. AbiEzzi, S.S., Gesink, D.S., Schreck, P.J., Amiel, D., Akeson, W.H. and Woods, V.L., Jr.: Increase

Expression of the ß1, α5, and αv Integrin Adhesion Receptor Subunits Occurs Coincident with Remodeling

Oates, K.M., Chen, A.C., Young, E.P., Kwan, M.K., A

569, 1995.

Sah, R.L., Amiel, D. and Coutts, R.D.: Tissue Engineering of Ar

Chu, C.R., Monosov, A.Z. and Amiel, D.: In Situ Assessment of Cell Viability With

Washington DC, 1994. Biomaterials 16(18):1381-1384, 1995.

Yoshioka, M., Coutts, R.D., Amiel, D. and

Amiel, D.: Intrinsic Properties of anterior cruciate ligament (ACL) and medial collateral ligament (MCL) Cells a

Convery, F.R., Akeson, W.H., Amiel, D., Meyers, M.H. and Mon

1088, 1996.

1Ligament Cell Adhesiveness. J Orthop Res 14:729-735, 1996.

Dr. David Amiel

25

26. Berry, S.M., Green, M.H. and Amiel, D.: Hyaluronan: A Potential Carrier for Growth Factors for the

127. alili, R.B., Yoshioka, M., Amiel, D. and Coutts, R.D.:

Physical Properties of Rabbit Articular Cartilage after Transection of the Anterior Cruciate Ligament.

28. AbiEzzi, S.S., Foulk, R.A., Harwood, F.L., Akeson, W.H. and Amiel, D.: Decrease in Fibronectin

ed

29. Yoshioka, M., Shimizu, C., Harwood, F.L., Coutts, R.D. and Amiel, D.: The Effects of Hyaluronan

30. Wada, Y., Amiel, M., Harwood, F. and Amiel, D: Architectural Remodeling of Fresh Meniscal

pair

32. Lane, J.G., Amiel, M.E., Monosov, A.Z. and Amiel, D.: Matrix Assessment of the Articular Cartilage

97. 133. Imanishi, J., Teshima, R. and

Hirasawa, Y.: Analysis of Heat Shock Proteins and Cytokines Expressed During Early Stages of

134. ., Iverson, E.P., Schinagl, R.M., Sonoda, M., Amiel, D., Coutts, R.D. and Sah, R.L.:

Quantitation and Localization of Cartilage Degeneration Following the Induction of Osteoarthritis in

135. F.L., Wada, Y., Moriya, H. and Amiel, D.: The Effects of Hyaluronan on the

Meniscus and on the Articular Cartilage After Partial Meniscectomy. Am J Sports Med 25(6):755-

136.

ssessment of Glycosaminoglycans in Articular Cartilage. J Orthop Res 15(5):670-674, 1997.

137. ndon rist Award for 1996, for

Cutting-Edge Research in Tissue Regeneration. Assoc Bone Joint Surg 1996. Clin Orthop

138. ., Goomer, R.S., Harwood, F.L., Khatod, M., Coutts, R.D. and Amiel, D.:

Chondrogenic Phenotype of Perichondrium-Derived Chondroprogenitor Cells is Influenced by

125. Lieber, R.L., Amiel, D., Kaufman, K.R., Whitney, J. and Gelberman, R.H.: Relationship Between Joint Motion and Flexor Tendon Force in the Canine Forelimb. J Hand Surg 21A(6):957-962, 1996.

1Healing of Ligamentous Tissues. Wound Repair and Regen 5(1):33-38, 1997.

Sah, R.L., Yang, A.S., Chen, A.C., Hant, J.J., H

J Orthop Res 15:197-203, 1997.

1Occurs Coincident with the Increased Expression of its Integrin Receptor α5ß1 in Stress-DeprivLigaments. Iowa Orthop J 17:102-109, 1997.

1During the Development of Osteoarthritis. Osteoarth and Cart 5(4):251-260, 1997.

1Allograft Transplantation in a Rabbit Joint: Its Long- Term Protective Effect on Articular Cartilage. J Orthop Sci Japan 2:171-179, 1997.

131. Chu, C.R., Dounchis, J.S., Yoshioka M., Sah R.L., Coutts, R.D. and Amiel, D.: Osteochondral Re

Using Perichondrial Cells: A 1-Year Study in Rabbits. Clin Orthop 340:220-229, 1997.

1Surface After Chondroplasty With the Holmium:YAG Laser. Am J Sports Med 25(4):560-569, 19

Takahashi, K., Kubo, T., Goomer, R.S., Amiel, D., Kobayashi, K.,

Osteoarthritis in a Mouse Model. Osteoarth and Cart 5:321-329, 1997.

Chang, D.G

the Rabbit Knee. Osteoarthritis and Cartilage 5:357-372, 1997.

Sonoda, M., Harwood,

762, 1997.

Shimizu, C., Coutts, R.D., Healey, R.M., Kubo, T., Hirasawa, Y. and Amiel, D.: Method of Histomorphometric A

Seiler, J.G. III, Chu, C.R., Amiel, D., Woo, S.L-Y. and Gelberman, R.H.: Autogenous Flexor TeGrafts: Biologic Mechanisms for Incorporation. Winner, Marshall R. U

345:239-247, 1997.

Dounchis, J.S

Transforming Growth Factor-Beta 1. J Orthop Res 15:803-807, 1997.

Dr. David Amiel

26

39. Shimizu, C., Yoshioka, M., Coutts, R.D., Harwood, F.L., Kubo, T., Hirasawa, Y. and Amiel, D.: Long

40. Wada, Y., Amiel, M., Harwood, F., Moriya, H. and Amiel, D.: Architectural Remodeling in Deep

41. Goomer, R.S., Maris, T.M. and Amiel, D.: Age-Related Changes in the Expression of Cadherin-11,

2-

is and 6-

998.

it

44. Shimizu, C., Kubo, T., Hirasawa, Y., Coutts, R.D. and Amiel, D.: Histomorphometric and

45. Harwood, F.L., Monosov, A.Z., Goomer, R.S., Gelberman, R.H., Winters, S.C., Silva, M.J. and

ovial Flexor 8.

46. Lieber, R.L., Silva, M.J., Amiel, D. and Gelberman, R.H.: Wrist and Digital Joint Motion Produce

147. M. and Amiel, D.: Articular Cartilage

Transplantation: Clinical Results in the Knee. Winner, Clin Orthop Soc Resident Research

148. , K., Goomer, R.S., Harwood, F., Kubo, T., Hirasawa, Y. and Amiel, D.: The Effects of

Hyaluronan on Matrix Metalloproteinase-3 (MMP-3), Interleukin-1ß (IL-1ß), and Tissue Inhibitor of

t -

50. Amiel, D., Chu, C.R., Sah, R.L. and Coutts, R.D.: Tissue Engineering of Articular Cartilage:

151.

n Orthopaedics Award, Societe Internationale de Recherché Orthopedique et de Traumatologie (SIROT) 99 Sydney Inter-Meeting, Freund Publ Co.,

1Term Effects of Hyaluronan on Experimental Osteoarthritis in the Rabbit Knee. Osteoarthritis Cart 6:1-9, 1998.

1Frozen Meniscal Allografts After Total Meniscectomy. Arthroscopy: The J Arthros and Rel Surg 14(3):250-257, 1998.

1the Mesenchyme Specific Calcium-Dependent Cell Adhesion Molecule. Calcif Tissue Intl 62(6):53537, 1998.

142. Hashimoto, S., Takahashi, K., Amiel, D., Coutts, R.D. and Lotz, M.: Chondrocyte Apoptos

Nitric Oxide Production During Experimentally Induced Osteoarthritis. Arthritis Rheum 41(7):1261274, 1

143. Lee, J., Harwood, F.L. Akeson, W.H. and Amiel, D.: Growth Factor Expression in Healing Rabb

Medial Collateral and Anterior Cruciate Ligaments. Iowa Orthop J 18:19-25, 1998.

1Biochemical Effect of Various Hyaluronans on Early Osteoarthritis. J Rheum 25(9):1813-1819, 1998.

1Amiel, D.: Integrin Expression Is UpRegulated During Early Healing In a Canine IntrasynTendon Repair and Controlled Passive Motion Model. Connect Tissue Res 39(4):309-316, 199

1Unique Flexor Tendon Force and Excursion in the Canine Forelimb. J Biomech 32(2):175-181, 1999.

Chu, C.R., Convery, F.R., Akeson, W.H., Meyers,

Award. Clin Orthop 360:159-168, 1999.

Takahashi

Metalloproteinase-1 (TIMP-1) Gene Expression During the Development of Osteoarthritis. Osteoarthritis and Cartilage 7(2):182-190, 1999.

149. Hart, R.A., Akeson, W.H., Spratt, K. and Amiel, D.: Collagen Fibril Diameter Distributions in Rabbi

Anterior Cruciate and Medial Collateral Ligaments: Changes with Maturation. Iowa Orthop J 19:6670, 1999.

1Perichondrial Cells in Osteochondral Repair. Cells and Materials 8:(1):161-174, 1999.

Amiel, D. and Goomer, R.S.: A Non-Viral Ex-Vivo Gene Therapy for the Repair of Full-Thickness Articular Cartilage Defects. Winner, Research i

pp. 3-20, 1999.

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2. Amiel D., Lee M-C. and Goomer, R.S.: Study of the Age-Related and Transforming Growth Factor lls.

--541, 1999.

Cells. Wound Repair and Regen 7(5):381-388, 1999

ation-ruciate Ligament. J Orthop

Res 17(5):745-747, 1999.

, R.H.:

57. Ahsan, T., Lottman, L.M., Harwood, F., Amiel, D. and Sah. R.L.: Integrative Cartilage Repair:

58. Kobayashi, K., Healey, R.M., Sah, R.L., Clark, J.J., Tu, B.P., Goomer, R.S. Akeson, W.H.,

air bbit Model. Am J Sports Med 28(1):90-97, 2000.

hological

Perichondrial Cells: An In Vitro Study. Iowa Orthop J 20:11-16, 2000.

163. onan on Chondrocyte Apoptosis and Nitric Oxide Production in Experimentally Induced Osteoarthritis. J

164. D.: Cartilage Repair with

Autogenic Perichondrium Cell and Polylactic Acid Grafts. Clin Orthop 377:248-264, 2000.

15Beta 1 (TGF-β1) Effect on the Proliferation and Chondrogenicity of Perichondrium-Derived CeSociete Internationale de Recherché Orthopedique et de Traumatologie, SIROT 99 Sydney InterMeeting, Freund Publ Co., pp. 534

153. Harwood, F.L., Goomer, R.S., Gelberman, R.H., Silva, M.J., Amiel, D.: Regulation of αvβ3 and α5β1

Integrin Receptors by Basic Fibroblast Growth Factor and Platelet-Derived Growth Factor-BB in Intrasynovial Flexor Tendon

154. Hashimoto, S., Takahashi, K., Ochs, R.L., Coutts, R.D., Amiel, D. and Lotz, M.: Nitric Oxide

Production and Apoptosis in Cells of the Meniscus During Experimental Osteoarthritis. Arthritis Rheum 42(10):2123-2131, 1999.

155. Goomer, R.S., Maris, T., Ostrander, R. and Amiel, D.: PT-12, a Putative ras Activated, Prolifer

dependent Gene, is Expressed in Patellar Tendon and Not in Anterior C

156. Silva, M.J., Brodt, M.D., Boyer, M.I., Morris, T.S., Dinopoulos, H., Amiel, D. and Gelberman

Effects of Increased In Vivo Excursion on Digital Range of Motion and Tendon Strength FollowingFlexor Tendon Repair. J Orthop Res 17(5):777-783, 1999.

1Inhibition by ß-Aminoproprionitrile. J Orthop Res 17(6):850-857, 1999.

1Moriya, H., and Amiel, D.: A Novel Method for the Quantitative Assessment of Cell Migration: A Study on the Motility of Anterior Cruciate and Medial Collateral Ligament Cells. Tissue Engineering 6(1):29-38, 2000.

159. Sonoda, M., Harwood, F.L., Amiel, M.E., Moriya, H., Temple, M., Chang, D.G., Lottman, L.M., Sah,

R.L. and Amiel, D.: The Effects of Hyaluronan on Tissue Healing After Meniscus Injury and Repin a Ra

160. Fujii, T., Takai, S., Arai, Y., Kim, W., Amiel, D. and Hirasawa, Y.: Microstructural Properties of the

Distal Growth Plate of the Rabbit Radius and Ulna: Biomechanical, Biochemical and MorpStudies. J Orthop Res 18(1):87-93, 2000.

161. Sonoda, M., Harwood, F.L., Amiel, M.E., Moriya, H. and Amiel, D.: The Effect of Hyaluronan on the

Meniscus in the Anterior Cruciate Ligament Deficient Knee. J Orthop Sci, Japan 5(2):157-164, 2000.

162. Lee, M.C., Goomer, R.S., Takahashi, K., Harwood, F.L., Amiel, M. and Amiel, D.: Transforming

Growth Factor Beta One (TGF-β1) Enhancement of the Chondrocytic Phenotype in Aged

Takahashi, K., Hashimoto, S., Kubo, T., Hirasawa, Y., Lotz, M. and Amiel, D.: Effect of Hyalur

Rheum 27(7):1713-1720, 2000.

Dounchis, J.S., Bae, W.C., Chen, A.C., Sah, R.L., Coutts, R.D. and Amiel,

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165. iel, D.: Cartilage Repair with Autogenic Perichondrium Cell/Polylactic Acid Grafts: A Two Year Study in Rabbits. J Orthop Res 18(3):512-515, 2000.

166. ffects of Hyaluronan During Development of Osteoarthritis Following Partial

Meniscectomy in a Rabbit Model. Osteoarthritis Cart 8(5):359-365, 2000.

167.

Orthop 379S, S189-

69. Goomer, R.S., Johnson, K.A., Burton, D.W., Amiel, D., Maris, T.M., Gurjal, A., Deftos, L.J. and

f PTHrP

70. Goomer, R.S., Deftos, L.J., Terkeltaub, R., Maris, T., Lee, M.C., Harwood, F.L., and Amiel, D.: High

Orthop Res 19(3):500-503, 2001.

172. dial

Meniscus Following Partial Meniscectomy. J Orthop Res 19(5):213-219, 2001.

173. pair Clin Orthop 389:228-237, 2001.

R.L., anical Assessment of Short Term Effects of

Osteochondral Autograft Plug Transfer in an Animal Model. Arthroscopy 17(8):856-863, 2001.

175. ehabilitation Force on Collagen Content and Maturation at the Intrasynovial

Flexor Tendon Repair Site. J Hand Surg 26(5):841-846, 2001.

176.

age Med

Dounchis J.S., Coutts, R.D. and Am

Kobayashi, K., Amiel, M., Harwood, F.L., Healey, R.M., Sonoda, M., Moriya, H. and Amiel, D.: The Long-Term E

Goomer, R.S. and Amiel, D.: Repair of Articular Cartilage Defects by Ex-Vivo Gene Therapy. Curr Opin Orthop 11(5):378-382, 2000.

168. Goomer, R.S., Maris, T., Gelberman R., Boyer, M., Silva, M. and Amiel, D.: Non-Viral In-Vivo Gene

Therapy for Tissue Engineering of Articular Cartilage and Tendon Repair. ClinS200, 2000.

1Terkeltaub, R.: The Tetrabasic KKKK147-150 Motif Determines Intracrine Regulatory Effects o1-173 on Chondrocyte PPi Metabolism and Matrix Synthesis. Endocrinology 141:4613-4622, 2000.

1Efficiency Non-Viral Transfection of Primary Chondrocytes and Perichondrial Cells for Ex-Vivo Gene Therapy to Repair Articular Cartilage Defects. Osteoarthritis Cartilage 9(3):248-256, 2001.

171. Takahashi, K., Hashimoto, S., Kubo, T., Hirasawa, Y., Lotz, M. and Amiel, D.: Hyaluronan

Suppressed Nitric Oxide Production in the Meniscus and Synovium of Rabbit Osteoarthritis Model. J

Kobayashi, K., Mishima, H., Hashimoto, S., Goomer, R.S., Harwood, F.L., Lotz, M., Moriya, H. and Amiel, D.: Chondrocyte Apoptosis and Regional Differential Expression of Nitric Oxide in the Me

Ostrander, R.V., Goomer, R.S., Tontz, W.L., Khatod, M., Harwood, F.L., Maris, T.M. and Amiel, D.: Donor Cell Fate in Tissue Engineering for Articular Cartilage Re

174. Lane, J.G., Tontz, W.L., Jr., Ball, S.T., Massie, J.B., Chen, A.C., Bae, W.C., Amiel, M.E., Sah,

Amiel, D.: A Morphological, Biochemical and Biomech

Goldfarb, C.A., Gelberman, R.H., Harwood, F., Amiel, D., Silva, M.J. and Boyer, M.I.: The Effect of Variations in Applied R

Coutts, R.D., Healey, R.M., Ostrander, R., Sah, R.L., Goomer, R. and Amiel, D.: Matrices for Cartilage Repair. Clin Orthop 391S:S271-279, 2001.

177. Lane, J.G., Amiel, M.E., Greenfield, R. and Amiel, D.: Matrix Assessment of the Articular Cartil

Surface After Chondroplasty with the Holmium:YAG Laser: A Long Term Study. Am J Sports 29(6):704-708, 2001.

Dr. David Amiel

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is Cartilage 10(3):180-187, 2002.

ee

181. Kobayashi, K., Mishima, H., Harwood, F., Hashimoto, S., Toyoguchi, T., Goomer, R., Moriya, H. and

-41, 2002. 182. ra, T., Harwood, F., Goomer, R., Hirasawa, Y. and Amiel, D.: Tissue Engineered Repair of

Osteochondral Defects: Effects of the Age of Donor Cells and Host Tissue. Tissue Eng 8(6):921-

183. er, R.S., Coutts, R.D., Akeson, W.H. Amiel, D. and Sah,

R.L.: Adhesion of Perichondrial Cells to a Polylactic Acid Scaffold. J Orthop Res 21(4):584-589,

184. miel, D., Gelberman, R.H. and Silva, M.J.: Two-Portal Repair

of Canine Flexor Tendon Insertion Site Injuries: Histologic and Immunohistochemical

185. Amiel, D., Toyoguchi, T., Kobayashi, K., Bowden, K., Amiel, M.E. and Healey, R.M.: Long-Term

186.. Williams, S.K., Amiel, D., Ball, S.T., Allen, R.T., Wong, V.W., Chen, A., Sah, R.L. and Bugbee, W.D.:

03.

pl 1}:213-223, 2003.

189. ects of

an Osteochondral Allografts. Clin Orthop 418:246-252, 2004

178. Silva, M.J., Boyer, M.I., Ditsios, K., Burns, M.E., Harwood, F.L., Amiel, D. and Gelberman, R.H.: The Insertion Site of the Canine Flexor Digitorum Profundus Tendon Heals Slowly Following Injury and Suture Repair. J Orthop Res 20(3):447-453, 2002.

179. Hashimoto, S., Creighton-Achermann, L., Takahashi, K., Amiel, D., Coutts, R.D. and Lotz, M.:

Development and Regulation of Osteophyte Formation During Experimental Osteoarthritis. Osteoarthrit

180. Yamada, K., Healey, R., Amiel, D., Lotz, M. and Coutts, R.D.: Subchondral Bone of the Human Kn

Joint in Aging and Osteoarthritis. Osteoarthritis Cartilage 10:360-369, 2002.

Amiel, D.: The Suppressive Effect of Hyaluronan on Nitric Oxide Production and Cell Apoptosis in the Central Region of Meniscus Following Partial Meniscectomy. Iowa Orthop J 22:39

Moriha

929, 2002.

Giurea, A., Klein, T.J., Chen, A.C., Goom

2003.

Boyer, M.I., Harwood, F., Ditsios, K., A

Characterization of Healing During the Early Postoperative Period. J Hand Surg 28(3):469-474, 2003.

Effect of Sodium Hyaluronate (Hyalgan®) on Osteoarthritis Progression in a Rabbit Model. Osteoarth & Cart 11(9):636-643, 2003.

Prolonged Storage Effects on the Articular Cartilage of Fresh Human Osteochondral Allografts. J Bone Joint Surg 85:2111-2120, 2003.

187. Bae, W.C., Temple, M.M., Amiel, D., Coutts, R.D., Niederauer, G.G. and Sah, R.L.: Indentation

Testing of Human Cartilage: Sensitivity to Articular Surface Degeneration. Arthritis Rheum 48(12):3382-3394, 20

188. Tasto, J.P., Cummings, J., Medlock, V., Harwood, F., Hardesty, R. and Amiel, D.: The Tendon

Treatment Center: New Horizons in the Treatment of Tendinosis. Arthroscopy 19(10){Sup

Ball, S.T., Amiel, D., Williams, S.K., Tontz, W., Chen, A.C., Sah, R.L., Bugbee, W.D.: The EffStorage on Fresh Hum

190. Ball, S.T., Goomer, R., Ostrander, R., Tontz, W., Williams, S.K. and Amiel, D.: Pre-Incubation of

Perichondrial Cells in a Polylactic Acid Scaffold Enhances Donor Cell Retention. Clin Orthop 420:276-285, 2004.

191. Bae, WC, Law, AW, Amiel, D, Sah, RL: Sensitivity of Indentation Testing to Step-Off Edges and

Interface Integrity in Cartilage Repair. Annals Biomed Eng (ABME) 32(3):360-369, 2004

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192. : Chondrocyte Viability and Metabolic Activity After Treatment of

Bovine Articular Cartilage With Bipolar Radiofrequency (RF). An In Vitro Study. Arthroscopy

193. Lane, J.G., Massie, J.B., Ball, S.T., Amiel, M. E., Chen, A.C., Bae, W.C., Sah, R.L. and Amiel, D.:

194. Allen, R.T., Robertson, C.M., Harwood, F.L., Sasho, T, Williams, S.K., Pomerleau, A.C. and Amiel,

Chondrocyte Apoptosis. Osteoarth Cart 12:917-923, 2004.

195. ent rosc Rev 12(4):210-219, 2004.

sho, T. rimental

Osteoarthritis. Annals Rheum Dis 64:89-94, 2005.

197. uces Less Hypersensitivity than Cross-Linked Hyaluronan. Clin Orthop 434:239-245, 2005.

198. s

thesis In Vitro. J Hand Surg 30A(3):441-447, 2005.

199.

05.

etics of Collagen Crosslinking in Adult Bovine Articular Cartilage. Osteoarth Cart 13(8):709-715, 2005.

201.

.L. and Amiel, D.: Analysis of Stored Osteochondral Allografts at the Time of Surgical Implantation. Am J Sports Med 33(10):1479-1484, 2005.

202.

Storage of Fresh Human Osteochondral Allografts by Gene Array Analysis. Clin Orthop 442:260-266, 2005.

203.

204. gner, F., Harwood, F.L., Bugbee, W.D. and Amiel, D.: Does

Subchondral Bone Affect the Fate of Osteochondral Allografts During Storage? Am J Sports Med

205. Debridement with

an Arthroscopic Radiofrequency Wand Vs and Arthroscopic Shaver: Comparative Effects on Menisci

Amiel, D., Ball, S.T. and Tasto, J.P.

20(5):503-510, 2004.

Follow-up of Osteochondral Plug Transfers in a Goat Model: A 6-Month Study. Am J Sports Med 32(6):1440-1450, 2004.

D.: Characterization of Mature versus Aged Rabbit Articular Cartilage: Analysis of Cell Density, Apoptosis-Related Gene Expression and Mechanisms Controlling

Tasto, J.P., Cummings, J., Medlock, V., Harwood, F., Hardesty, R. and Amiel, D.: Tendon TreatmCenter. Sports Med Arth

196. Shikhman, A.R., Amiel, D., D’Lima, D., Hwang, S-B, Hu, C., Hashimoto, S., Kobayashi, K., Sa

and Lotz, M.K.: Chondroprotective Activity of N-Acetylglucosamine in Rabbits with Expe

Goomer, R.S., Leslie, K., Maris, T. and Amiel, D.: Native Hyaluronan Prod

Thomopoulos S, Harwood FL, Silva MJ, Amiel D, Gelberman RH. Effect of Several Growth Factoron Canine Flexor Tendon Fibroblast Proliferation and Collagen Syn

Tasto, J.P., Cummings, J., Medlock, V., Hardesty, R. and Amiel, D.: Microtenotomy using a Radiofrequency Probe to Treat Lateral Epicondylitis. Arthroscopy 21(7):851-860, 20

200. Ahsan, T., Harwood, F., McGowan, K.B., Amiel, D. and Sah, R.L.: Kin

Allen, R.T., Robertson, C.M., Pennock. A.T., Bugbee, W.D., Harwood, F.L., Wong, V.W., Chen, A.C., Sah, R

Robertson, C.M., Allen, R. T., Bugbee, W.D., Harwood, F.L., Healey, R.M. and Amiel, D.: Upregulation of Apoptotic and Matrix Related Genes During Prolonged

Amiel, D.: Letter to the Editor, Am J Sports Med 34(2):315-316, 2006

Pennock, A.T., Robertson, C.M., Wa

34:586-591, 2006.

Allen, R.T., Tasto, J.P., Cummings, J., Robertson, C.M. and Amiel, D.: Meniscal

and Underlying Articular Cartilage. Arthroscopy 22(4):385-393, 2006.

Dr. David Amiel

31

., :

anically and Histologically Inferior to Surface Repair in a Canine Model. J Orthop Res, 24(5):990-1000, 2006.

207. Following Induction of

Osteoarthritis in Mature and Aged Rabbits. Osteoarth Cart 14(5):471-476, 2006.

208. fts: Does the Addition of Fetal Bovine Serum Improve Chondrocyte Viability? J

Knee Surg 19(4):265-272, 2006.

209. Aging Rather than Osteoarthritis. Osteoarth Cart

15(5):559-565, 2007.

210. totic

During Development of Osteoarthritis. Arth Rheum 56(5):1529-1536, 2007.

211. lief ter Radiofrequency Application. Am J Sports Med (AJSM)

35(5):805-810, 2007.

212. e, W.D.: Fresh Osteochondral Allografting in the Treatment of Osteochondritis Dissecans of the Femoral Condyle.

213. iyama-Elbert, S.

and Gelberman, R.H.: PDGF-BB Released in Tendon Repair Using a Novel Delivery System

214.

ated Biomechanical Weakening of Human Articular Cartilage of the Femoral Condyle. Osteoarth Cart 15:1042-1052, 2007.

215. n after Radiofrequency Application. Am J Sports Med 35(11):1940-1944, 2007.

216. ery, .D.: Analysis of Cartilage Tissue on a Cellular Level in Fresh

Osteochondral Allograft Retrievals. Am J Sports Med 35(12):2022-2032, 2007.

217. Spinal Growth Modulation with an Anterolateral Flexible

Tether in an Immature Bovine Model: Disc Health and Motion Preservation. Spine 33(7):724-733,

218. miel, D.: The Protective Effect of OP-1 on

Articular Cartilage in the Development of Osteoarthritis. Osteoarth Cart 16(5):600-606, 2008.

206. Silva, M.J., Thomopoulos, S., Kusano, N., Zaegel, M.A., Harwood, F.L., Matsuzaki, H., Havlioglu, NDovan, T.T., Amiel, D. and Gelberman, R.H.: Early Healing of Flexor Tendon Insertion Site InjuriesTunnel Repair is Mech

Robertson, C.M., Pennock, A.T., Harwood, F.L., Pomerleau, A., Allen, R.T., and Amiel, D.: Characterization of Pro-Apoptotic and Matrix Degradative Gene Expression

Pennock, A.T., Wagner, F., Harwood, F.L., Bugbee, W.D. and Amiel, D.: Prolonged Storage of Osteochondral Allogra

Mitsuyama, H., Healey, R.M., Terkeltaub, R.A., Coutts, R.D. and Amiel, D.: Calcification of Human Articular Knee Cartilage is Primarily an Effect of

Pennock, A.T., Robertson, C.M., Emmerson, B.C., Harwood, F.L., Amiel, D.: The Role of Apopand Matrix-Degrading Genes in Articular Cartilage and Meniscus of Mature and Aged Rabbits

Takahashi, N., Tasto, J.P., Ritter, M., Ochiai, N., Ohtori, S., Moriya, H. and Amiel, D.: Pain ReThrough an Anti-Nociceptive Effect af

Emmerson, B.C., Gortz, S., Jamali, A.A., Chung, C., Amiel, D. and Bugbe

Am J Sports Med (AJSM) 35(6):907-914, 2007.

Thomopoulos, S., Zaegel, M., Das, R., Harwood, F.L., Silva, M.J., Amiel, D., Sak

Promotes Cell Proliferation and Collagen Remodeling. J Orthop Res 25(10):1358-1368, 2007.

Temple, M.M., Bae, W.C., Chen, M.Q., Amiel, D., Coutts, R.D. and Sah, R.L.: Age- and Site-Associ

Ochiai, N., Tasto, J.P., Ohtori, S., Takahashi, N., Moriya, H. and Amiel, D.: Nerve Regeneratio

Williams, S.K., Amiel, D., Ball, S.T., Allen, R.T., Tontz, W.L., Emmerson, B.C., Badlani, N., EmS.C., Haghighi P, Bugbee, W

Newton, P.O., Farnsworth, C.L., Faro, F.D., Mahar, A.T., Odell, T.R., Mohamad, F., Breisch, E.A., Fricka, K.B., Upasani, V.V. and Amiel, D.:

2008.

Badlani, N., Inoue, A., Healey, R., Coutts, R. and A

Dr. David Amiel

32

19. Campbell, P.H., Hunt, D.L., Jones, Y., Harwood, F., Amiel, D., Omens, J.H. and McCulloch, A.D.: llular

20. Sakiyama-Elbert, S., Das, R., Gelberman, R.H., Harwood, F., Amiel, D. and Thomopoulos, S.:

221. a, M., Sakiyama-Elbert, S., Harwood, F., Zampiakis, E., Kim, H-M.,

Amiel, D. and Gelberman, R.: Enhanced Flexor Tendon Healing Through Sustained Delivery of

2. Badlani, N., Oshima, Y., Healey, R., Coutts, R. and Amiel, D.: Use of Bone Morphogenic Protein-7

as a Treatment for Osteoarthritis. Clin Orthop 467(12):3221-3229, 2009.

.

.

man Articular Cartilage of the Femoral Condyle. Osteoarth Cart 17(11):1469-1476, Nov 2009.

225. in 9

. PUBLICATIONS IN PROGRESS

. Lane, J.G., Healey, R.M., Sah, R.l., Chen, A.C-S. and Amiel, D.: Can Osteochondral Grafting be

Augmented with Microfracture in an Extended Sized Lesion of Articular Cartilage. Accepted, Am J Sports Med, AMJSPORTS/2009/068486, December 2009.

2. Tracy, S.C., Tasto, J.P., Oshima, Y., Murata, R., Garcia, J. and Amiel, D.: The Effect of Butyric Acid

on Normal Tendons: A Potential Stimulus of Extracellular Matrix Compression. Submitted to Am J Orthop, January 2010.

3. Thomopoulos, S., Kim, H.M., Das, R., Silva, M.J., Sakiyama-Elbert, S., Amiel, D. and Gelberman,

R.H.: The Effects of Exogenous bFGF on Intrasynovial Flexor Tendon Healing: A Biomechanical, Biochemical and Histological Study in Canines. Accepted with revisions, J Bone Joint Surg, MS#S09-02324, January 2010.

2Effects of Biglycan Deficiency on Myocardial Infarct Structure and Mechanics. Molec CeBiomech 5(1):27-36, 2008.

2Controlled Release Kinetics and Biologic Activity of PDGF-BB for Use in Flexor Tendon Repair. J Hand Surg [Am] 33(9):1548-1557, 2008.

Thomopoulos, S., Das, R., Silv

PDGF-BB. J Orthop Res 27(9):1209-1215, 2009.

22

223 Lane, J.G., Healey, R. and Amiel, D.: Changes in Condylar Coefficient of Friction after Osteochondral Graft Transplantation and Modulation with Hyaluronan. Arthroscopy: J Arthrosc, 25(12):1401-1407, 2009.

224 Temple-Wong, M.T., Bae, W.C., Chen, M.Q., Bugbee, W.D., Amiel, D. Coutts, R.D., Lotz, M. and

Sah, R.L.: Biomechanical, Structural and Biochemical Indices of Degenerative and Osteoarthritic Deterioration of Adult Hu

Oshima, Y., Harwood, F.L., Coutts, R.D., Kubo, T. and Amiel, D.: Variation of Mesenchymal Cells Polylactic Acid Scaffold in an Osteochondral Repair Model. Tiss Eng 15(4):595-604, Dec 200

1