curriculum vitae daniel g. remick, md 617-414 …...daniel remick, m.d., cv november 2018 curriculum...

Daniel Remick, M.D., CV November 2018 Curriculum Vitae

Daniel G. Remick, MD 670 Albany Street, Rm., 407

617-414-7043 [email protected]

ACADEMIC TRAINING: 1982 MD Mayo Medical School Rochester, MN 1978 BS University of Minnesota Duluth, MN

POSTDOCTORAL TRAINING: 7/1984-6/1986 Fellow, Immunopathology, University of Michigan Ann Arbor, MI, 7-1982-6/1984 Resident, Pathology, University of Michigan, Ann Arbor, MI

ACADEMIC APPOINTMENTS: 9/2006-Present Chair and Professor, Boston University School of Medicine 9/1998-8/31/06 Professor, Department of Pathology, University of Michigan Medical School 9/1992-8/1998 Associate Professor, Department of Pathology, University of Michigan Medical

School 9/1988-8/1992 Assistant Professor, Department of Pathology, University of Michigan Medical

School 9/1986-8/1988 Instructor University of Michigan Medical School OTHER PROFESSIONAL POSITIONS AND MAJOR APPOINTMENTS 9/2002-8/31/06 Assistant Dean of Admissions, University of Michigan Medical School, 1987-2006 Director, Autopsy Service University of Michigan Health Systems 6/1985-8/31/06 Deputy Medical Examiner, Washtenaw County, MI Washtenaw County, MI

HOSPITAL APPOINTMENTS: 2006-Present Staff Pathologist, Boston Medical Center

AWARDS, HONORS AND NAMED LECTURER: 2018 Gustave Dammin Lecture, Brigham & Women’s Hospital, Boston MA 2017 President, American Society of Investigative Pathology 2014 American Society of Investigative Pathology, Elected Council Member 2014 Elected Chair, Research Committee, Association of Pathology Chairs 2013 Keynote speaker, 11th Annual Advances in Inflammation Research, Brown

University, The roles of adenosine and antibodies in sepsis 2013 Chair and invited speaker, 46th Annual Meeting of the Society for Leukocyte

Biology, Providence Rhode Island, Leukocytes and mediators that influence survival 2013 Keynote Speaker, 15th Congress of the European Shock Society, Vienna Austria,

Sepsis, When you die we want to know why 2013 Meet the Expert, Ludwig Boltzmann Institute of Traumatology, Vienna Austria 2013 Selected as Program Chair, 2014 Society for Leukocyte Biology Annual Meeting 2013 Elected Chair, Research Committee, Association of Pathology Chair 2012 President elect, New England Society of Pathologists 2012 Presented annual John F. Sander and Nancy K. Dunkel Lecture, Michigan State

University, The Inflammatory Response in Sepsis 2011 Mentor for Kendra Iskander, M.D., recipient Travel Award Shock Society 2011 Mentor for Rituparna Moitra, finalist New Investigator Award, Shock Society

mailto:[email protected]

Daniel Remick, M.D. July 2018 page 2

2011 Mentor for Jacqueline Bouchard, graduate student, recipient of ASIP travel award 2011 Elected to Council, American Society of Investigative Pathology 2011 Nominated, Robbins Teaching Award 2010 Elected Chair, Advocacy Committee, Association of Pathology Chairs 2010 Presented 8th Annual John Spitzer Distinguished Lecture, Louisiana State University

Health Sciences Center, March 25. Sepsis Complex Inflammation for a Complex Disease

2010 Mentor for Bryan Belikoff, MD\PhD student, Travel Award from American Society of Investigative Pathology

2010 Elected to council, Society of Leukocyte Biology 2009 President, Shock Society 2009 Selected by the BUSM class of 2012 to serve on the Appeals Committee for

Academic Promotion 2009 Mentor for Florin Craciun, graduate student, recipient of Shock Society’s Travel

Award 2008 President-elect, Shock Society 2008 Distinguished Service Award, Shock Society 2006 Mentor - Marcin Osuchowski, recipient of the Shock Society’s Young Investigator

Award 2006 American Red Cross Certificate of Appreciation for Extraordinary Personal Action 2003 Mentor - Liyu Xing, Ph.D., recipient of American Society of Investigative Pathology

Travel Award 2001 Medical Student Teaching Award for Teaching Excellence, University of Michigan

Medical School 1999 Mentor - Douglas Call, Ph.D., recipient of American Society of Investigative

Pathologists Experimental Pathologist in Training Award 1996 Burroughs Welcome Visiting Professor, St. George’s Hospital, London England 1994 Supervisor for Laura DeForge, Ph.D., recipient of American Society of Investigative

Pathology Experimental Pathologist in Training Award 1980-82 Class Representative, Mayo Medical School 1980-82 Alworth Memorial Scholarship Recipient 1980-82 Honors in Chemistry 1978 BS Summa Cum Laude LICENSES AND CERTIFICATION: 10/02/06 Massachusetts #230385 State of Michigan, #4301046219

BOARD CERTIFICATION: 2012 - 2022 Voluntary recertification, American Board of Pathology 1986 Board Certification, Anatomic Pathology, American Board of Pathology 1983 Board Certification, Diplomate of National Board of Medical Examiners

DEPARTMENTAL AND UNIVERSITY COMMITTEES: Boston University: 2017 Member, Cardiff University site visit team for Boston University 2017-2019 Member LCME site visit preparation team 2017 – 2018 Chair, Standard 9 LCME site visit preparation team 2016-2017 Chair, Search Committee, Shipley Prostate Cancer Research Professor


2016 Member, Search Committee, Amyloid Center Director 2016 Member, Search Committee, Department of Surgery Chair 2015 – 16 Chair, Search Committee M.D., Ph.D. Director 2014 Member, Search Committee Milunsky Endowed Professorship 2009-2013 Student Appeals Committee 2009-2010 Conflict of Interest Committee, individual and institutional committees 2009 Chair, Search Committee for Chief of Pulmonary Center 2008-2009 Medical School Bylaws Revision Task Force 2008-present Microarray Core Advisory Committee 2008 Ad hoc committee for faculty evaluation 1/08 Ad hoc Committee, Review of Structure of Graduate Medical Sciences 2007 Academy of Advisors Member 11/07 - 2010 Task Force, BU Medical School in Abu Dhabi 10/1/07-06/08 Chair, Search Committee to select Dean of the Goldman School of Dental Medicine 1/1/2007 Basic Science Review Committee, Education Sub Committee 2006-present MD\PhD Admissions committee 11/1/2006 Search Committee, Hematology Oncology Section Chi 10/1/2006 Search Committee, Whitaker Cardiovascular Institute 2006-present Graduate Medical Sciences Executive Committee 9/1/2006 Executive Committee Boston Medical Center: 2016 Chair, Office of Research Integrity Inquiry 2016 Member, Search Committee, Chair of Surgery 2015 Member, Search Committee, Chair of Radiology 2012 Member, Search Committee, Department of Obstetrics and Gynecology Chair 2011 Member, Search Committee, Department of Surgery Chair 2011 Elected member, Finance Committee, Physicians Organization 2010-2011 Co-chair, Research Integration Task Force, Boston Medical Center and Boston

University 2006-present Medical Executive Committee - Member 2007-2009 New Technologies Committee – Member 2006-present BMC patent committee 2006 Search Committee, Chief of Cardiothoracic Surgery–Member University of Michigan Medical School: 2001-2006 Member, Selection Committee for the Paul Gikas, M.D. scholarship for medical

school from the Department of Pathology 2001-2004 Member, University of Michigan Faculty Senate 2001-2003 Curriculum Policy Committee, Medical School 2000-2006 Admissions Executive Committee, Medical School 2000-2004 Member, Department of Emergency Medicine Committee on Appointments,

Promotions and Tenure 2000-2001 Member, Faculty Space Planning Committee 1999-2006 Program in Biological Sciences, Admissions Committee 1999-2000 Chair, ACAPT 1998-2001 Chair, University Committee on Use and Care of Animals 1997-2001 University Committee on Use and Care of Animals


1997-2000 Advisory Committee on Appointments, Promotions and Tenure, Instructional Tract (ACAPT)

1996-1997 Senate Assembly 1995-2006 Reviewer, Biomedical Research Council grants 1995-2006 Reviewer, Department of Surgery grants 1993-2001 Director, Electron Microscopy Laboratory, The University of Michigan, Ann Arbor,

Michigan 1990-2006 Medical School Admissions Committee 1987-2006 Director, Autopsy Service, Department of Pathology, The University of Michigan,

Ann Arbor, Michigan University of Michigan Hospital: 2002- 2006 Task Force on End of Life Care 1996-2006 Trauma/Burn Conference

TEACHING EXPERIENCE AND RESPONSIBILITIES:

Boston University 2018 Faculty Marshall, Graduation, Graduate Medical Sciences Division, Boston

University School of Medicine 2018 Grand Marshall, Graduation Boston University School of Medicine 2013 – present Participant, Responsible Conduct of Research Workshops, 4 contact hours per year 2015 – present Spotlight lectures (2) on immunology for respiratory and oncology 2013-present Co-Director MS131 and PA510 Medical Immunology 2011-present Boston University MD520 A1 (Dental School Pathology), Acute and Chronic

Inflammation, 2 lectures 2011-present Boston University PA600/700 General Pathology, Acute and Chronic Inflammation 2011-present Boston University MS 223 Diagnosis and Therapy, Mechanisms of Autoimmune

Diseases 2010-present Diagnosis and Therapy Course, Acute and Chronic Inflammation 2 lectures 2008-present Boston University Diagnosis and Therapy M2 course, Disorders of vascular flow and

shock 2007-present Diagnosis and Therapy MS 223, CNS infections 2007-present Course Co-Director PA 801 Special Topics Pharmacologic inhibition of the

inflammatory response, presented 2 lectures 2007-present Two lectures, MI 713 Comprehensive Immunology Cytokines 2006 Integrated Problems Pathology 600 University of Michigan: 2001 Medical Student Teaching Award, University of Michigan 1999-2006 Pathology 581 Tissue, cellular and Molecular Basis of Disease 1999-2002 Course Director, Pathology 850 Research Seminar Series in Pathology 1997-1999 Laboratory Instructor, Pathology 585, medical illustrators 1996-2006 Laboratory Instructor, Pathology 630, M2 pathology course, lab instructor 1994-2006 Laboratory Instructor, Histopathology Laboratory for M1 students 1994-2006 Lecturer, Pathology 600 Course 1994-present Lectures to Pathology House Officers in Anatomic and Clinical Pathology


1994 Instructor, Research Colloquium in Experimental Pathology (Pathology 850), The University of Michigan Medical School

1993 Lecturer, Statistics of Pathology, Department of Pathology House Officers, University of Michigan Medical Center, Ann Arbor, Michigan

1993-1996 Lecturer, Infectious Disease Sequence, Sophomore Medical Students, The University of Michigan Medical School, Ann Arbor, Michigan

1987-2006 Twice weekly Gross Conference, Autopsy Service, The University of Michigan Medical School, Ann Arbor, Michigan

1985-2006 Mentor, Fourth Year Medical Student Clerkship, The University of Michigan Medical School, Ann Arbor, Michigan

1985-1991 Course Director, Pathology for Sophomore Dental Students (Pathology 631), The University of Michigan Medical School, Ann Arbor, Michigan

1982-1984 Laboratory Instructor, Sophomore Pathology Course (Pathology 600), The University of Michigan Medical School, Ann Arbor, Michigan

MAJOR MENTORING ACTIVITIES: K08 mentees

Saman Arbabi, M.D., M.P.H Professor of Surgery U of Washington GM 69437 Mark Hemmila, M.D. Associate Professor of Surgery U of Michigan GM 78610 Jean Nemzek, D.V.M Assistant Professor of Laboratory Animal

Medicine, U of Michigan GM 65486

Rebecca Minter, M.D. Associate Professor of Surgery. U of Michigan GM 74678 Catherine Valentine, M.D. Assistant Professor of Medicine, Boston University GM 100090

Prior trainees in academic medicine, in addition to K08 awardees

Devina Prakash, M.D. Associate Professor of Pediatrics, Stony Brook University School of Medicine Douglas Call, Ph.D. Professor, Department of Veterinary Microbiology and Pathology, and

Caroline Engle Faculty Fellow, Washington State University Mark Eskandari, M.D. Professor, Northwestern University Feinberg School of Medicine, James S. T.

Yao Professor Education in Vascular Surgery, Chief of Vascular Surgery Stewart Wang, M.D., Ph.D.

Endowed Professor of Surgery, University of Michigan Medical School

Devin Horton, Ph.D. Assistant Professor of Biology, Fort Valley State University Marcin Osuchowski, D.V.M., Ph.D.

Investigator – Ludwig Institute of Traumatology, Vienna Austria (this is a private research institute with basic science investigators led by Heinz Redl, and is the equivalent of working at a US research institute such as the Trudeau Institute)

Louis Vaickus, M.D., Ph.D.

Assistant Professor of Pathology, Dartmouth School of Medicine (effective July 1, 2016)

Graduate students trained: 2016 Terry Hsieh, returned to medical school 2014 Evan Chiswick, Ph.D., Postdoctoral Fellow MIT 2013 Dominic Beal, Ph.D. 2013 David Stepien, M.D., Ph.D., Resident in reconstructive surgery U of Michigan 2012 Jacqueline Bouchard, Ph.D., Staff Scientist Abbott Labs 2012 Ritruprana Moitra, Ph.D., post-doctoral fellow, National Institutes of Health


2010 Louis Vaickus, MD\PhD Assistant Professor of Pathology, Dartmouth School of Medicine

2010 Bryan Belikoff, MD\PhD Radiology Residency Washington University 2010 Florin Craciun, post-doctoral fellow, Brigham and Women’s Hospital 2009 Sudha Natarajan, Post doctoral fellow, Boston University through August 2012.

Currently enrolled in Nurse Practitioner program at MGH Institute for Health Professions.

2009 Devin Horton, Assistant Professor, Fort Valley State University 2005 Laura McKinley, Wyeth Pharmaceuticals (2008) 2004 Andrew Merry, Yale University (2005) Graduate Students or Medical Students Trained: Thesis Committee – graduated students 2004 Erin Gatza, Program in Immunology, University of Michigan 2004 Victor Mwaspa, School of Public Health, Department of Epidemiology, University

of Michigan 2002 Jill Murtha, Department of Pathology, University of Michigan 2001 Jian Zhang, Department of Pathology, Role of osteoprotegrin in osteoclastogenesis

in prostate cancer 1997 Jami Lou-Martin Foreback, Department of Pathology PBMC cytokine production

following stimulation by IgG subclasses or IgA 1993 Carole Ann Winegardner Conn, Department of Physiology The effects of exercise

and food restriction on the acute phase response Thesis Committees - University of Michigan 2005 Yoko Kamotani, College of Engineering 2002 Kelli Breen, candidate, Department of Physiology U of Michigan Thesis Committees - Boston University 2018 Jessica Kenison, Department of Pathology 2018 Gregory Hall, D.V.M., Department of Pathology 2017 Mark Wojnarowicz, Department of Pathology 2017 Nisma Mujahid, Department of Pathology 2017 Elizabeth Moses, Department of Pathology 2015 Jason Sutin, Department of Pathology 2013 Martin Steinbuck, Department of Pathology - Chair 2013 Melody Lun, Department of Pathology - Chair 2012 Nicole Stauffer, Department of Pathology 2012 Clarissa Koch, Department of Pathology 2012 Parul Agothi, Department of Pathology 2011 Jillian Richmond, Department of Pathology 2011 Tim Hanley, M.D., Ph.D, student, Department of Microbiology 2010 Louis Vaickus, M.D., Ph.D. student, Department of Pathology 2010 Bryan Belikoff, M.D., Ph.D. student, Department of Pathology 2009 John Meyers, Department of Pathology 2009 David Davis, Department of Pathology 2009 Jillian Richmond, Department of Pathology 2009 Heather Cohen, Department of Pathology


2008 Jennifer Burke, Department of Pathology Previous students in the laboratory Years in lab Student’s name, Current Position 2002 Elizabeth Orlowski, Pathology resident Vanderbilt 1998 Sunir Garg, ophthamalogist 1996-97 Robert Cohen, now Medical Student, Wayne State 1996-99 David Newcomb, Emergency Medicine Resident, U of Michigan 1994 Angela Dyer, D.V.M. student from MSU 1986-91 Eskandari, M., Chief of Vascular Surgery, Northwestern University Post-doctoral fellows trained Years in lab Fellow’s name, Current Position 2013 – 2016 Bethany Lussier, M.D. 2012 – 2014 Elizabeth King, M.D. 2011 – 2013 Guastavo Bauza, M.D. 2011 – 2013 Juan Mella, M.D. 2010 – 2013 Kendra Iskander, M.D., M.P.H. 2011-2012 Sudha Natarajan, Ph.D. 2008 Robin Craig, Ph.D. 2005-2007 Marcin Osuchowschi, D.V.M., Ludwig Institute of Traumatology, Vienna Austria 2004-2006 Michelle Law, Ph.D. 2002-05 Ekram El Laban, M.D., Ph.D. 2001-04 Hong Yan Xiao, M.D., now Post-Doctoral Fellow, U of Michigan 2000-03 Liyu, Xing, now Research Associate II, U of Michigan 1999-2002 Kim, John, now Research Assistant Professor, Boston University 1997-2000 Nemzek, Jean, D.V.M., now Associate Professor, U of Michigan 1997-99 Pia Nybom, Ph.D., now Ciphergen 1997-99 Call, Douglas, now Professor, Department of Veterinary Microbiology and

Pathology, and Caroline Engle Faculty Fellow, Washington State University 1996-99 Ebong, Samuel, now Post-doctoral fellow, NIH 1993-96 Villarete, Lorelie, now Director of Research, Calypte Inc. 1993-95 Prakash, Devina, now SUNY Stony Brook, Assistant Professor 1992-95 Wollenberg, Gordon, now Merck 1989-92 DeForge, Laura, now Scientist, Genetech

Current Patents US Patent 7,056,503 B2. Date of issue June 6, 2006 Enclosures for housing cell-coated supports for treating tumors. Inventors Riley Rees, Jiyoun Kim, Daniel Remick and Belinda Adamson. Assignee Regents of the University of Michigan MAJOR ADMINISTRATIVE RESPONSIBILITIES:

2006-present Chair, Department of Pathology and Laboratory Medicine 2006-present President, Boston University Mallory Pathology Associates, Inc. 2011- 2014 Chair, Finance Committee, Faculty Practice Plan, Boston Medical Center and Boston

University

OTHER PROFESSIONAL ACTIVITIES:


PROFESSIONAL SOCIETIES: MEMBERSHIPS, OFFICES, AND COMMITTEE ASSIGNMENTS Regional Dates Committee 2013-2014 President, New England Society of Pathologists 2004-2006 Executive Committee to the Center for Statistical Consultation and Research 1998-2006 Member, Michigan Coalition on Donation 1997-2001 Chair, Michigan Association of Medical Examiners 1997-2001 Member, Michigan Medical Examiner Database Project, Michigan Public 1995-1997 Secretary, Michigan Association of Medical Examiners 1994, 1995 Program Chair, Michigan Association of Medical Examiners Annual Meeting, 1993-2006 Executive Committee, Michigan Association of Medical Examiners 1989-1998 Co-Chair, Michigan Department of Health Dementia Committee, Michigan

Dementia Post-Mortem Network Health Institute National Dates Committee 2018 Representative to the Co-operating Societies, American Board of Pathology 2017-2018 President, American Society of Investigative Pathology 2014 – 2016 Moderator, Pathology Roundtable All major pathology organizations participate in

discussions concerning common pathology issues 2014 – 17 Chair, Research Committee, Association of Pathology Chairs 2014 Program Chair, Society for Leukocyte Biology Annual Meeting 2011-2013 Chair, Advocacy Session Association of Pathology Chairs Annual Meeting 2011–2015 Elected Council Member, Society for Leukocyte Biology 2011–2017 Elected Council Member, American Society for Investigative Pathology 2011 Chair, Advocacy Session at the Association of Pathology Chairs. Recruited Dora

Hughes, M.D., Scientific Counselor to the Secretary of Health and Human Services as Keynote Speaker

2010-2013 Chair, Advocacy Committee, Association of Pathology Chairs 2010-2011 Chair, Shock Society Strategic Planning Committee 2009-present Member, Research Committee, Association of Pathology Chairs 2008-present Member, Advocacy Committee, Association of Pathology Chairs 2008-2013 Member of Council, Shock Society 2006 Program Chair, Shock Society’s Annual Meeting, Denver CO 2002-present Member, Education Committee, American Society of Investigative Pathologists 2001- 2005 Shock Society, Organizer, Young Investigator Research Forum 2001- present Shock Society, Program Committee 1998-2004 Shock Society, Honors and Award Committee 1985 – present American Society of Investigative Pathology, member Editorial Boards Dates Journal 2015 – 2016 Guest Editor, Journal of Leukocyte Biology 2013 – 2018 Editorial Board, American Journal of Pathology 2012 - 2016 Section Editor, Journal of Immunology 2007-Present Editor, Microbes and Infection 2006-Present Associate Editor, Shock


2001 – Present Editorial Board, J of Infectious Diseases 2001-2006 Editorial Board, Journal of Investigative Surgery 1999-2001 Associate Editor, Journal of Immunology 1998-2006 Executive Editor, Cross Section (Official Newsletter of the Michigan, Association of

Medical Examiner Memberships, Offices, Professional Societies: United States and Canadian Academy of Pathology Shock Society American Association of Immunologists Association of Pathology Chairs American Society of Investigative Pathology Society for Leukocyte Biology SCIENTIFIC ACTIVITIES

2018 Panel member, American Society of Investigative Pathology PISA meeting, Maximizing Biospecimen Resources

2017 Chair, Search Committee for new Executive Officer, American Society of Investigative Pathology

2017 Wiggers-Bernard Conference Participant, Ludwig Boltzmann Institute of Experimental and Clinical Traumatology, Vienna Austria, Pre-clinical Modeling in Sepsis

2016 Invited participant, NIH workshop on physician scientist workforce 2016 External Reviewer, Department of Pathology, University of Iowa 2015 - present External Reviewer, GBMed, Graz Austria Government/University/Private enterprise

to evaluate biomarkers 2015 Board of Scientific Review, National Institute of Arthritis, Musculoskeletal and Skin

Diseases – ad hoc reviewer 2014–18 Charter Member National Heart, Lung and Blood Institute Mentored Clinical and

Basic Science Review Committee 2007 - Present Shriner’s Grant Review Panel, Burn Grants, Tampa Florida 2012 Jun Chair, P50 Review panel 2012 Feb Lung, Cellular and Molecular Immunology Study Section 2011 Dec Member, NIH study section on ancillary use grants 2011 Sept Member, NIH review committee SBIR grants 2011 August Member, NIH special emphasis panel 2011 June NIH P50 Review Panel 2011 March Chair, NIH P50 Review Panel 2011 February NASA grant review 2010 Jun NIH K08 review panel 2010 Jun NASA grant review 2010–4 Reviewer, Charles King Trust Fellowship grants 2009 Oct NIH Special Emphasis Panel 2009 June NIH Challenge grant review 2009 August Air Force grant review 2009 February NIH Special Emphasis Panel 2008 July CDC Biodefense grant review, Atlanta Georgia 2008 May NASA grant review, Washington DC


2008 February NIH Special Emphasis Panel 2007 August Chair, NIH Special Emphasis Panel, Review Of Program Project Grants For General

Medical Sciences 2007 May On Site Reviewer Oklahoma Medical Research Foundation NIH U19 grant 2006 Jun On Site Reviewer Oklahoma Medical Research Foundation NIH U19 grant 2006 Jun Chair, NIH Special Emphasis Panel, Surgery, Anesthesiology and Trauma 2006 Jan Chair, NIH Special Emphasis Panel, Surgery Anesthesiology and Trauma 2005 Nov Chair, NIH Program Project Review, Newark, New Jersey 2005 Nov Chair, NIH Special Emphasis Panel, Surgery Anesthesiology and Trauma 2005 Jul Chair, NIH Special Emphasis Panel, Review Of Program Project Grants For General

Medical Sciences 2005 Jul Chair, NIH Special Emphasis Panel, Surgery, Anesthesiology and Trauma 2005 Jun On Site Reviewer Oklahoma Medical Research Foundation NIH U19 grant. 2005 Jan Chair, NIH Special Emphasis Panel 2004 Dec NIH Special Emphasis Panel 2004 Jun Chair, NIH Special Emphasis Panel 2004 Feb Chair, NIH Special Emphasis Panel 2003 Sep Chair, NIH Special Emphasis Panel 2002 Oct NIH Special Emphasis Panel 2002 Jun NIH Special Emphasis Panel 2002 Feb NIH Special Emphasis Panel 2001-3 Chair, NIH Surgery, Anesthesiology and Trauma Study Section 2001 Nov NIH Special Emphasis ZRG 1 IFCN-4 2001 June Chair, NIH Special Study Section ZRG1-SSSW 2001 Feb Chair, NIH Special Study Section ZRG1-SSSW 1998-2001 National Institutes of Health, Surgery, Anesthesiology, Trauma Study Section,

regular member 1997 Ad-hoc Reviewer, NIH, Surgery, Anesthesiology, Trauma Study Section 1997 NIH Site Visit, Trauma primes cells, Principal Investigator: Alden Harkin, M.D.

Denver Colorado 1996 Ad-hoc Reviewer, NIH, Surgery, Anesthesiology, Trauma Study Section 1993 NIH Reverse Site Visit, Case Western Reserve SCOR Grant, February. 1993 NIH Review Section, Expression of TB in the Lung, Bethesda, Maryland. 1992 NIH Telephone Site Visit, Supplement to Dr. John Spitzer's Program Project, LSU

Medical Center 1991 Ad-hoc Reviewer, NIH, Surgery, Anesthesiology, Trauma Study Section 1989-98 Co-Chair, Michigan Department of Public Health Postmortem Examination

Workgroup 1989 NIH Site Visit, LSU Medical Center Program Project, January

Current Other Support: 7/01/2010-6/30/2021 T32 GM86308, (Remick, PI), Immunobiology of Trauma, The grant will provide 2

years of training for 2 physician scientists each year. 09/05/2017-08/31/2018 R01GM117519, Remick, PI. $150,000 direct costs Mechanisms of augmented host defenses after mild brain injury.

Recent Other Support:


9/11/2011-8/31/2016 1.8 calendar months, NIH/R01 GM 97320 (Remick, contact PI) NIGMS, $250,000. Title: Adenosine and Oxygen Modulate Antimicrobial Defenses. This grant explores the role of extracellular oxygen and adenosine in phagocytic cell function during sepsis.

3/05/2014-2/29/2016 R21 AA022122, Remick, PI, $150,000 annually Title”Alcohol Triggered Asthma: Mechanisms of Neuronal Control. This grant will

study how drinking alcohol will trigger asthma in mice, using a cockroach allergen model.

07/1/14 – 6/30/16 R21 AI112887, Remick PI $150,000 annually Title: Mechanisms of phagocytic cell defects induced by inhibitory IgG. This grant

will study how a specific inhibitory IgG blocks the killing of bacteria in an animal model.

4/01/2009-3/31/2014 1.8 calendar months, R01 GM82962-01 (Remick, PI), NIH/NIGMS $250,000. Role

of Cytokines in Sepsis and Trauma. The major goals of this grant are to define the immunological alterations in sepsis that lead to multi-organ injury and death, to define treatments which may be more effective.

9/01/06- 8/31/11 1.2 calendar, R01 ES0113538-01 (Remick, PI) , NIH/NIEHS, $304,945. Endotoxin,

Allergens and Pollutants in Asthma. The major goals of this grant are to explore the inflammatory response to a novel model of murine asthma like pulmonary inflammation.

12/01/05-11/30/10 2.40 calendar, 5, R01 GM050401 (Remick, PI), NIH/NIGMS, $225,000,

Regulation of Ongoing Inflammation. The major goals of this project are to decipher the molecular pathways regulating ongoing inflammation.

5/15/05-04/30/09 P01 GM067189-01A2 (Remick, PI), NIH/NIGMS, Immunopathology of Sepsis,

Project #1, Role of cytokines in Sepsis and Trauma , Project Leader, $157,486,. 3.00 calendar, Core B Cytokine Measurement Core, Core Director , $191,091, 60 calendar. This program project examines the inflammatory response in patients who have suffered a traumatic injury.

1990-2004 30% effort, National Institutes of Health, GM44918 - The Role of Cytokines in

Sepsis and Trauma - Principal Investigator - 4 years; $906,182 - direct costs. 1998 – 2004 National Institutes of Health, Michigan Center for the Environment & Health,

ES09589 project #2, Chemokines in the Pathogenesis of Asthma, Principal Investigator, 5 years, $1,181,250 direct costs., 10% effort

2001-2004 Michigan Life Sciences Initiative N002518, Can Paraxonase be Used to Treat

Endotoxemia and Sepsis, Principal Investigator Bert Ladu, M.D., Ph.D., Co-Investigator Daniel Remick, $150,000 direct costs, 0% effort


2000- 2003 National Institutes of Health, HD040112, Neuroimmunology/Cytokine Alterations In Vulvodynia, Principal Investigator, Barbara Reed, Co-Investigator Daniel Remick, $375,000, 0% effort.

2000-2001 National Institutes of Health, TW 00908, Training Med School Faculty to Tackle

Malaria in Malawi, subcontract, Principal Investigator Daniel Remick, $12,000 direct costs.

1997-2000 Upjohn-Pharmacia, Immunomodulatory properties of sulphasalazine, Principal

Investigator, $49,920, total costs.. 1996-97 Schering-Plough Corporation IL-10 in the treatment of the Jarisch-Herxhemier

reaction, Principal Investigator 1 year, $12,000, direct costs. 1996 -1997 Novartis - PMX binding of endotoxin, Principal Investigator, direct costs $6,500. 1994-96 Schering Plough Corporation - IL-10, Principal Investigator, direct costs $31,500.

G. Burroughs Wellcome Travel Fund, Principal Investigator, direct costs $3,890, 1995

1992- 1993 Pfizer, Measurement of Cytokines in Human Whole Blood - Principal Investigator direct costs $26,000.

1991-1995 National Institutes of Health - Hepatic Ischemia Induced TNF and Multi-organ Injury - Principal Investigator - $1,059,537 - Direct Costs.

1990-1995 National Institutes of Health - Monokine Gene Expression/Regulation in Lung Injury - Co-investigator - 5 years.

1990-1993 National Institutes of Health - Myocardial Preconditioning in Conscious Dogs and Pigs - Co-Investigator - $131,792 - Direct Costs.

1991-1993 Cutter Biological - Measurement of Cytokines in Sepsis Syndrome - Principal Investigator $360,000 - Direct Costs.

1990-1991 Michigan Memorial Phoenix Project - Role of Tumor Necrosis Factor in Sepsis and Trauma -Principal Investigator - direct costs $3,000.

1990-1991 Rackham Graduate School of Medicine, The University of Michigan - Role of Tumor Necrosis Factor in Sepsis and Trauma -Principal Investigator, direct costs $10,000.

1989-1991 American Heart Association of Michigan - The Role of TNF and PAF in Septic Shock - Principal Investigator - 2 years - $43,500 - Direct Costs.

1988- 1991 NIH GM39339 FIRST Award -Granulomatous Inflammation and Interleukin 2 -Principal Investigator - direct costs, $350,000; - Note: This award was terminated early to allow activation of an RO1 grant from NIH.

1987-1988 Biomedical Research Council of the University of Michigan - Modulation of IL-2 Production - Principal Investigator - direct costs $4000.

1987- 1988 Rackham Graduate School of Medicine, The University of Michigan - Granulomatous Inflammation and Interleukin 2 - Principal Investigator - direct costs $10,000.

1987-1988 Michigan Memorial Phoenix Project - Granulomatous Inflammation and Interleukin 2 - Principal Investigator - direct costs Total Award $5,000.

1987 NIH Small Equipment Support Grant for purchase of Sterilizer - Principal Investigator - direct costs $23,000.

1987-1988 The University of Michigan Cancer Research Center - Role of Tumor Necrosis Factor in Pulmonary Malignancies - Principal Investigator - direct costs $7,500.


1984-1994 National Institutes of Health - Inflammatory Cells and Lung Injury - Co-Investigator - 5 years - $48,595 - Direct Costs.

Invited Lectures and Presentations 2018 University of Iowa Department of Pathology Annual Research Day, Keynote speaker 2018 University of New York – Stony Brook, Department of Pathology Research

Symposium, Keynote speaker 2018 Participant, Pathology Advocating for Academic Pathology Discussion Group,

Association of Pathology Chairs 2018 annual meeting 2018 Invited Speaker, New Pathology Chairs Bootcamp, When, Why, and How to

Transition from Being a Chair 2018 Presidential Symposium, Experimental Biology, Mild Traumatic Brain Injury

Augments Innate Immunity 2018 Damin Lecture, Brigham and Women’s Hospital, Boston MA, Heterogeneity in the

Septic Response 2018 Grand Rounds, University of Pittsburgh Department of Pathology, Pittsburgh PA,

Sepsis Heterogeneity 2017 Invited speaker, Cardiff University, Cardiff, Wales, Mild Traumatic Brain Injury

Augments Innate Immunity 2017 Chair, Organ Injury Working Group on Preclinical Models of Sepsis, 9th Wiggers-

Bernard Conference at the Ludwig Bolzmann Institute in Vienna, Austria. 2017 Invited Speaker, American Thoracic Society’s annual meeting in Washington DC.

Heterogeneity in the Septic Inflammatory Response 2017 Invited speaker, Department of Neurology Grand Rounds, Boston Medical Center 2017 Invited speaker, Houston Methodist Hospital First Annual Resident Research Day,

Mild Traumatic Brain Injury Augments Innate Immunity 2016 Grand Rounds Speaker, Yale School of Medicine, Department of Pathology,

Traumatic Brain Injury Augments Hose Defenses 2016 Grand Rounds Speaker, Boston Medical Center, Department of Internal Medicine,

Sepsis: A Moving Target 2016 Invited Speaker, Pathology Leadership Academy, Unique Leadership Challenges in

the Research Mission 2016 Workshop organizer, Association of Pathology Chairs, Biorepository Management

Workshop 2016 Organizer, Association of Pathology Chairs annual meeting, research session, You

Won’t Believe Your Eyes – 21st Century Optics in Pathology 2016 Chair, 39th Annual Conference on Shock, Austin TX, Pro-con debate Is

Coagulopathy an Appropriate Target during Critical Illness. 2016 Invited Speaker – Shock Society – Preparation of a CV and Mock Interview 2015 Invited speaker, Institute of Neuroscience & Physiology Sahlgrenska Academy -

University of Gothenberg, Mild traumatic brain injury augments host responses 2015 Invited speaker, Satellite Symposium on Alcohol and Immunology, Raleigh NC:

Acute ethanol ingestion triggers asthma 2015 Chair, 38th Annual Conference on Shock, Denver CO. Pro-Con Debate: Is the

Inflammatory Response a Worthy Target in Sepsis 2015 Keynote Address, 12th Annual Forum on Sepsis at the Latin-American Institute for

Sepsis, Sao Paulo Brazil, Pathophysiologic Mechanisms in Septic Shock


2015 Thematic Session – Therapeutic Interventions, 12th Annual Forum on Sepsis at the Latin-American Institute for Sepsis, Sao Paulo Brazil, Do Inhibitory Immunoglobulins Decrease Pathogen Killing and Increase Sepsis Mortality

2015 Thematic Session, Special Situations in Sepsis, 12th Annual Forum on Sepsis at the Latin-American Institute for Sepsis, Sao Paulo Brazil, Brain Injury and Pneumonia Prevention

2015 Keynote Address, University of Damman, Saudi Arabia, 1st Annual Scientific Research Update – Traumatic Brain Injury Augments Pulmonary Host Responses to Bacteria: Molecules and Mechanisms

2015 Specialized Workshop, King Fahd Hospital University of Damman, Saudi Arabia, Immunopathology of Sepsis - 2015

2014 Grand Rounds, Department of Surgery at Loyola University Medical Center – Brain Injury Prevents Pneumonia – Who knew?

2014 Invited Lecture, Department of Pathology at Loyola University Medical Center Physician Scientist Pathway in Pathology

2014 Dr. Remick as an invited speaker at the Burn and Shock Trauma Research Institute at Loyola University – Chicago Inhibitory IgG Increases Sepsis Mortality

2014 Invited Moderator, Shock Society workshop Finding Your Scientific Niche and Establishing Yourself as an Independent Investigator

2013 Keynote speaker, European Shock Society, Vienna, Austria 2013 Visiting Professor, Brown University, Department of Surgery 2013 Invited speaker, Shock Society, Oxidant regulation of chemokine gene expression 2013 Invited speaker, Society for Leukocyte Biology, Macrophage Plasticity in Innate

Immunity 2012 Invited participant, Grant writing workshop, Society for Leukocyte Biology 2012 Chair, Society for Leukocyte Biology Plenary Session, The Interplay between Innate

and Th2 Immunity 2012 Invited speaker, Louisiana State University College of Veterinary Medicine,

Department of Pathobiologic Sciences and Comparative Biomedical Science, Mechanisms of Organ Injury in Sepsis

2012 Invited speaker, Brown University Pathobiology Retreat, Macrophages, Antibodies and Adenosine Interactions in Sepsis Survival

2011 Visiting Professor, Wayne State University, Alcohol Exacerbated Asthma 2011 Visiting Professor, University of Cincinnati, Immunopathology of Trauma 2011 Visiting Professor, Xavier University, What chemicals cause asthma, Cockroaches,

Pollution, Alcohol 2010 Chair – American Society of Investigative Pathologists –Experimental Biology

Meeting April, Genetics and Molecular Biomarkers of Disease and Nanotechnology 2010 Moderator – Shock Society Thirty-Third Annual Conference on Shock June, Mini-

symposium: Organ Dysfunction – Mechanisms and Therapies 2010 Co-Chair – Shock Society Thirty-Third Annual Conference on Shock June, Where

are they now? Reports from previous young investigator award winners 2010 Grand Rounds – Temple University Department of Pathology, June, Sepsis and the

Complex Inflammatory Response 2010 Grand Rounds – Boston Medical Center, Boston MA, Pathogenesis of Cockroach

Allergen Induced Asthma 2010 Invited Presentation, 8th Congress on Trauma, Shock, Injury and Sepsis, Munich

Germany, Lessons Learned from Experimental Peritonitis Models


2010 Invited Presentation, 8th Congress on Trauma, Shock, Injury and Sepsis, Munich Germany, Pulmonary Endotoxin Tolerance – Spare the Lung but Kill the Bacteria

2010 8th Congress on Trauma, Shock, Injury and Sepsis, Munich Germany, Moderator for session: Immune Dysfunction in Sepsis in Injury Animals/Patients: Update on Immunopathogenesis and Pathophysiolog 15.

2010 Grand Rounds, Brigham and Women’s Hospital, Boston MA, Sepsis, The Inflammatory Response

2010 8th Annual John Spitzer Distinguished Lecture, Louisiana State University Health Sciences Center, March 25, Sepsis Complex Inflammation for a Complex Disease

2010 Invited presentation, Northeast American Association for Clinical Chemistry, Waltham MA, Sepsis Biomarkers

2009 Co-Chair, Coagulation and Inflammation Symposium, Shock Society Meeting, San Antonio Tx

2009 Professor, University of Vermont Department of Pathology, Sepsis, What We Don’t Know May Kill you

2009 Grand Rounds, Johns Hopkins University, Immunopathology of Sepsis 2008 Invited Speaker, American Society of Investigative Pathologist Summer Academy,

Washington D.C, Immunopathology of Systemic Inflammation 2008 Invited Speaker, 31st Annual Shock Society Meeting, Cologne Germany, Multiplex

immunoprofiling of sepsis patients 2008 Invited Speaker, Forsythe Institute, Boston MA, Sepsis Understanding the

inflammatory Response 2008 Invited Speaker, University of Massachusetts Medical School, Immunopathology of

Sepsis 2008 Invited Speaker, Eisai Research Institute, Andover Massachusetts, The Inflammatory

Response in Lethal and Non-lethal Sepsis 2008 Invited Speaker, Society of Critical Care Medicine, Honolulu, Hawaii, Chemokines

in Sepsis and other Inflammatory Disorders 2008 Invited Speaker, Society of Critical Care Medicine, Honolulu, Hawaii, Cecal

Ligation and Puncture, Gold Standard or Inadequate Surrogate 2007 Visiting Professor, Massachusetts General Hospital, Sepsis: What we do not know

may kill you. 2007 Visiting Professor, Brown University, Immunopathology of Sepsis 2007 Invited Speaker, Scientific Sleuthing of Human Disease for High School Teachers,

American Society of Investigative Pathologists, Washington D.C., Pathogenesis of Asthma

2007 Invited Speaker, Trauma, Shock, Injury and Sepsis, Munich Germany, Animal Models of Peritonitis

2007 Invited Speaker, Trauma, Shock, Injury and Sepsis, Munich Germany, Class prediction with high throughput proteomics

2007 Invited Speaker, Society of Critical Care Medicine, Orlando Florida, If I had 100 million dollars, the future of sepsis research

2007 Visiting Professor, Sackler Graduate School Tufts University, Sepsis What we don’t know may harm you

2006 Keynote Speaker, European Shock Society, Ulm, Germany, Biomarkers of Sepsis 2006 Invited Speaker, Shock Society, Broomfield CO, Six at Six 2006 Keynote Speaker, Wound Healing Society, Phoenix, AZ, Quantitative Protein Chip

Microarrays


2006 Visiting Professor, Oklahoma Medical Research Foundation, The Complex Immunopathology of Sepsis

2006 Site reviewer for Paul Knight, M.D., Ph.D., SUNY – Buffalo, SCOR grant on lung injury

2006 Site reviewer Daniel Traber, Ph.D., NIH Program Project Pathophysiology of Lung Injury by Smoke Inhalation, University of Texas Medical Branch Galveston

2006 Invited Speaker, Society of Critical Care Medicine, San Francisco, Interleukin 6 Serves as a Sensitive and Specific Biomarker of Sepsis

2005 Invited Speaker, American Association of Medical Colleges, Washington D.C, Using Internet Chat Rooms to Communicate with Medical School Applicants

2005 Invited Panelist, American Association of Medical Colleges, Washington D.C., Forging Relationships Between Admission Offices and Development Officers

2005 Visiting Professor, Mayo Clinic, Rochester, MN, Understanding the Inflammatory Response in Sepsis

2005 Consultant, Blantyre Malaria Project, Blantyre, Malawi (Africa) Pathogenesis of Human Cerebral Malaria

2005 Invited Speaker, Society for Critical Care Medicine, Phoenix, AZ, Sepsis and Cytokines

2005 Invited Speaker, Association of University Anesthesiologists, Baltimore, MD, Making the Grant Reviewer Your Friend

2004 Panel Member, Minority Student Recruitment Fair, University of Florida, Gainesville, FL

2004 Invited Speaker, American Association of Medical College Annual Meeting, Boston, MA, Admissions Decisions and Disabilities

2004 Member Panel Discussion, American Association of Medical College Annual Meeting, Boston, MA, Michigan Affirmative Action, One Year Later

2004 International Sepsis Forum, Oak Island Resort, Canada, Acute Pancreatitis, Models, Markers, and Mediators

2003 Member Panel Discussion, American Association of Medical Colleges Annual Meeting, Washington D.C., Disabilities in Medical School

2003 Expert Panel Discussion, Michigan Association of Medical Examiners 2003 Symposium Chair, Shock Society Annual Meeting, Magic Bullets for the Treatment

of Sepsis 2003 Chair, Experimental Biology Poster Discussion Session 2003 Invited speaker, Keystone Symposium on Sepsis, Lake Tahoe, California 2003 Keynote Speaker, State University of New York at Buffalo, Research Day, The

Inflammatory Response of Sepsis 2003 Faculty Forum Speaker, Camp Michigania 2003 Organizer and Moderator, Magic Bullets for the Treatment of Sepsis Shock Society

meeting 2002 Faculty presenter, Camp Michigania 2002 Invited Speaker, State of Michigan Response to Bioterrorism, Michigan Association

of Medical Examiners, Mt. Clemens, Michigan 2002 External Reviewer, SCCOR grant, SUNY – Buffalo, Buffalo, New York 2002 Moderator, Therapies in Treatment of Shock, Shock Society Meeting, Big Sky

Montana 2002 Chair Experimental Biology Poster Discussion Session, Vascular Biology, New

Orleans


2002 Chair, Experimental Biology Poster Discussion Session Pulmonary Inflammation, New Orleans

2002 Visiting Professor, Washington State University, Pullman, Washington, Understanding the Inflammatory Response to Sepsis to Guide Therapy

2001 Visiting Professor, North Shore University Hospital, Manhasset, New York, Six at Six, Understanding the Inflammatory Response to Guide Therapy

2001 Visiting Professor, Department of Pathology, State University of New York, Stony Brook, Understanding the Inflammatory Response in Sepsis to Guide Patient Therapy

2001 Invited presentation, Esperion Therapeutics, Ann Arbor, Michigan The Immunopathology of Sepsis

2001 Visiting Professor, Institute Mario Negri, Milan, Italy, Using the Inflammatory Response to Sepsis to Guide Therapy

2000 Invited Speaker, Experimental Biology, Molecular Analysis of Lung Injury Minisymposium, Genetic Redundancy and the Inflammatory Response

2000 Visiting Professor, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma, The Immunopathology of Sepsis, Why doesn’t anything work?

2000 Invited Speaker, 5th International Congress on the Immune Consequences of Shock, Inflammation, and Sepsis, Munich, West Germany, Combination Immunotherapy With Soluble Tnf Receptors (Tnf-Sr) Plus Interleukin 1 Receptor Antagonist (Il-1ra) Decreases Sepsis Mortality

2000 Visiting Professor, Cleveland Clinic Foundation, Department of Immunology Cleveland, Ohio, Too Much Is Never Enough, The Inflammatory Response to Sepsis

2000 Visiting Professor, Washington University School of Medicine, Department of Surgery, St. Louis, MO, Sepsis, Nothing Works, But Have We Learned Anything?

1999 Invited presentation, Pioneer High School Health Occupations Class, Ann Arbor, Michigan, Value of Autopsies in Modern Society

1999 Visiting Professor, University of Natal, Durban South Africa, Department of Pathology, Cytokine regulation by reactive oxygen and reactive nitrogen intermediates.

1999 Invited Speaker, Shanghai Institute of Materia Medica, Shanghai, China Regulation of Cytokine Gene Expression

1999 Visiting Professor, Beijing Medical University, Institute of Vascular Medicine, Beijing, China, Reactive oxygen and the regulation of chemokines

1999 Visiting Professor, Michigan State University Department of Surgery, Lansing Michigan, Role of Reactive Oxygen Intermediates and Reactive Nitrogen Intermediates in Chemokine Gene Expression

1999 Visiting Professor, Michigan State University Department of Surgery, Lansing Michigan Sepsis – Nothing Works

1998 Invited Speaker, Children’s Environmental Health and Disease Prevention Research Centers, Research Triangle Park, North Carolina, Murine Chemokines in Asthma

1998 Keynote Speaker, Michigan Dementia Postmortem Network Conference, Michigan State University, The Value of Autopsy in Modern Society

1998 Visiting Professor, Norwegian University of Science and Technology, Trondheim, Cytokines and Sepsis, the Evolving Story

1997 Participant, G-CSF, Amgen Inc, Santa Monica, California 1996 Visiting Professor, Case Western Reserve University, Cleveland Ohio, The role of

cytokines in inflammatory bowel disease, Nov 18 - 19, 1996.


1996 Participant, G-CSF, Amgen Inc, Santa Monica, California 1996 Participant, Lysofylline, Cell Therapeutics Incorporated, San Francisco 1996 Speaker, Anti-TNF antibodies reduces the lethality of sepsis but not true sepsis,

Sepsis/SIRS, reducing the mortality to patients and suppliers, Washington D.C. 1996 Visiting Professor, Cytokine Gene Expression in the Jarisch Herxheimer Reaction,

St. George’s Medical School, London, England 1996 Visiting Professor, Oxidant Regulation of Cytokine Gene Expression, Royal

Hammersmith Hospital, London, England 1995 Participant, Washtenaw County Medical Examiners Roundtable Discussion, Ann

Arbor, Michigan 1995 Speaker, Animal Models of Sepsis, Michigan Laboratory Animal Medicine Society,

Ann Arbor, Michigan 1995 Program Director, 1995 Michigan Association of Medical Examiners Meeting,

Midland Michigan 1995 Participant, Washtenaw County Medical Examiner’s Roundtable Discussion 1995 Visiting professor “The Role of Cytokines in Infectious Disease”, University of

Illinois 1995 Speaker “Strategies for Use of Cytokine Inhibitors”, Deaconess Hospital Course 1995 Speaker “Measurement of Cytokines, Protein and mRNA”, Michigan Society for

Clinical Laboratory Science 1994 Organizer and participant, Michigan Association of Medical Examiners Annual

Meeting, Midland, MI 1994 Speaker “Update on Cytokines”, American Society of Clinical Pathology 1993 Speaker, Immunomodulation of Cytokines, Amgen, Thousand Oaks, California 1993 Speaker, Michigan State Medical Society, Update on Dementia 1993 Speaker, Cellular, Biochemical and Molecular Aspects of Reperfusion Injury, New

York Academy of Sciences, New York City, New York 1993 Speaker, Malnutrition in the Hospitalized Patient, Harvard Medical School, Boston,

Massachusetts 1993 Speaker, Modulation of Cytokine Toxicity and Control of Malignant Inflammation,

St. Louis University School of Medicine, St. Louis, Missouri 1993 Chair, Anti-Oxidant Defense Session, FASEB, New Orleans, Louisiana 1992 Participant, Quantitation of Human Anti-Mouse Antibodies, Miles, Inc., New Haven,

Connecticut 1992 Participant, Anti-TNF Therapy in Sepsis Syndrome, Cutter Biological, San

Francisco, California 1992 Speaker, Hyperalimentation: A Practical Approach, Harvard Medical School,

Boston, Massachusetts 1992 Visiting Professor Speaker, Regulation of Cytokine Gene Expression - Program of

Critical Care Medicine, St. Paul's Hospital, Vancouver, British Columbia, Canada 1992 Visiting Professor, Regulation of Cytokine Gene Expression - Program of Critical

Care Medicine, Vancouver General Hospital, Vancouver, British Columbia, Canada 1992 Speaker, Mediators of Inflammation - Wound Healing Society, Richmond, Virginia 1992 Speaker, Regulation of Tumor Necrosis Factor - 3M Company, St. Paul, Minnesota 1992 Speaker, Workshop on Cytokine and Growth Factor Pathology, Basel, Switzerland 1991 Speaker, Immunopathology Series, Cytokines - American Society of Clinical

Pathologists, New Orleans


1991 Lecturer, Regulation of Tumor Necrosis Factor - Department of Surgery, New York Medical Center

1990 Lecturer, Tumor Necrosis Factor - Department of Surgery, Michigan State University, Lansing, Michigan

1989 Lecturer, Regulation of Tumor Necrosis Factor - Pfizer Pharmaceutical, Groton, Connecticut

1988 Lecturer, Rusch Science Seminar, Concordia College, Ann Arbor, Michigan, 1988 Lecturer, Upjohn Corporation, Sterile Motrin I.V. Sepsis Study Group, Chicago,

Illinois 1988 Lecturer, Tumor Necrosis Factor - Proximal Mediator of Septic Shock, Department

of Surgery, Hershey Medical Center, Hershey, Pennsylvania 1988 Lecturer, Tumor Necrosis Factor - Mediator of Septic Shock, Department of

Pathology, University of Minnesota, Duluth, Minnesota 1983 Lecturer, MTP 400, Pathophysiology, Eastern Michigan University, Ypsilanti,

Michigan

Bibliography:

ORIGINAL, PEER REVIEWED ARTICLES:

H-INDEX = 75 (WEB OF SCIENCE)

RELATIVE CITATION RATIO 1.64, TOTAL PEER-REVIEWED PUBLICATIONS =282

MYNCBI:HTTP://WWW.NCBI.NLM.NIH.GOV/MYNCBI/BROWSE/COLLECTION/40490213/?SORT=DATE&DIRECTION=DESCENDING

1. Remick DG, Ayala A, Chaudry I, Coopersmith CM, Deutschman C, Hellman J, Moldawer L, Osuchowski M. Premise for Standardized Sepsis Models. Shock. 2018. PubMed PMID: 29877959.

2. Reed BD, Plegue MA, Sen A, Haefner HK, Siddiqui J, Remick DG. Nerve Growth Factor and Selected Cytokines in Women With and Without Vulvodynia. J Low Genit Tract Dis. 2018;22(2):139-46. PMID: 29570566.

3. Kasotakis G, Starr N, Nelson E, Sarkar B, Burke PA, Remick DG, Tompkins RG, Inflammation, Host Response to Injury I. Platelet transfusion increases risk for acute respiratory distress syndrome in non-massively transfused blunt trauma patients. Eur J Trauma Emerg Surg. 2018. PMID: 29627883.

4. Alekseyev YO, Fazeli R, Yang S, Basran R, Maher T, Miller NS, Remick D. A Next-Generation Sequencing Primer-How Does It Work and What Can It Do? Acad Pathol. 2018;5:2374289518766521. PMID: 29761157; PMCID: PMC5944141.

5. Kasotakis G, Galvan M, King E, Sarkar B, Stucchi A, Mizgerd JP, Burke PA, Remick D. Valproic acid mitigates the inflammatory response and prevents acute respiratory distress syndrome in a murine model of Escherichia coli pneumonia at the expense of bacterial clearance. J Trauma Acute Care Surg. 2017;82(4):758-65. PMID: 28099388; PMCID: PMC5360476

6. Hsieh T, Vaickus MH, Remick DG. Enhancing Scientific Foundations to Ensure Reproducibility: A New Paradigm. Am J Pathol. 2018;188(1):6-10. PMID: 28958817; PMCID: PMC5745519

7. Kasotakis G, Galvan MD, Osathanugrah P, Dharia N, Bufe L, Breed Z, Mizgerd JP, Remick DG. Timing of valproic acid in acute lung injury: prevention is the best therapy? J Surg Res. 2017;220:206-12. PubMed PMID: 29180183; PMCID: PMC5726455

8. Mella JR, Chiswick E, Stepien D, Moitra R, Duffy ER, Stucchi A, Remick D. Antagonism of the Neurokinin-1 Receptor Improves Survival in a Mouse Model of Sepsis by Decreasing Inflammation


and Increasing Early Cardiovascular Function. Crit Care Med. 2017;45(2):e213-e21. PMID: 27632670; PMCID: PMC5243197

9. Osuchowski MF, Thiemermann C, Remick DG. Sepsis-3 on the Block: What Does It Mean for Preclinical Sepsis Modeling? Shock. 2017;47(5):658-60. PMID: 28410332

10. Hsieh T, Vaickus MH, Stein TD, Lussier BL, Kim J, Stepien DM, Duffy ER, Chiswick EL, Remick DG. The Role of Substance P in Pulmonary Clearance of Bacteria in Comparative Injury Models. Am J Pathol. 2016;186(12):3236-45. doi: 10.1016/j.ajpath.2016.08.014. PubMed PMID: 27876152

11. Iskander KN, Vaickus M, Duffy ER, Remick DG. Shorter Duration of Post-Operative Antibiotics for Cecal Ligation and Puncture Does Not Increase Inflammation or Mortality. PLoS One. 2016;11(9):e0163005. PMID: 27669150; PMCID: PMC5036876

12. Xu H, Remick DG. Pathology: A Satisfying Medical Profession. Acad Pathol. 2016;3:2374289516661559. PMID: 28725775; PMCID: PMC5497859

13. Fan SL, Miller NS, Lee J, Remick DG. Diagnosing sepsis - The role of laboratory medicine. Clin Chim Acta. 2016;460:203-10

14. Cannon AR, Morris NL, Hammer AM, Curtis B, Remick DG, Yeligar SM, et al. Alcohol and inflammatory responses: Highlights of the 2015 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol. 2016;54:73-7

15. Chiswick EL, Mella JR, Bernardo J, Remick DG. Acute-Phase Deaths from Murine Polymicrobial Sepsis Are Characterized by Innate Immune Suppression Rather Than Exhaustion. J Immunol. 2015;195(8):3793-802. PMID: 26371253; PMCID: PMC4592823

16. Bauza G, Remick D. Caffeine Improves Heart Rate Without Improving Sepsis Survival. Shock. 2015;44(2):143-8. PubMed PMID: 25944789; PMCID: PMC4504769

17. Byrne-Dugan CJ, Cederroth TA, Deshpande A, Remick DG. The Processing of Surgical Specimens With Forensic Evidence: Lessons Learned From the Boston Marathon Bombings. Arch Pathol Lab Med. 2015;139(8):1024-7. PMID: 25521801

18. Drechsler S, Weixelbaumer KM, Weidinger A, Raeven P, Khadem A, Redl H, van Griensven M, Bahrami S, Remick D, Kozlov A, Osuchowski MF. Why do they die? Comparison of selected aspects of organ injury and dysfunction in mice surviving and dying in acute abdominal sepsis. Intensive Care Med Exp. 2015;3(1):48. PMID: 26215812; PMCID: PMC4513036

19. Yang S, Stepien D, Hanseman D, Robinson B, Goodman MD, Pritts TA, Caldwell CC, Remick DG*, Lentsch AB*: Substance p mediates reduced pneumonia rates after traumatic brain injury, Crit Care Med 2014, 42:2092-2100, PMID: 25014065 *=co-senior authors

20. Mella JR, Chiswick EL, King E, Remick DG: Location, Location, Location: Cytokine Concentrations are Dependent on Blood Sampling Site, Shock 2014, PMID: 25004061

21. Osuchowski MF, Remick DG, Lederer JA, Lang CH, Aasen AO, Aibiki M, Azevedo LC, Bahrami S, Boros M, Cooney R, Cuzzocrea S, Jiang Y, Junger WG, Hirasawa H, Hotchkiss RS, Li XA, Radermacher P, Redl H, Salomao R, Soebandrio A, Thiemermann C, Vincent JL, Ward P, Yao YM, Yu HP, Zingarelli B, Chaudry IH: Abandon the Mouse Research Ship? Not Just Yet!, Shock 2014, PMID: 24569509

22. King EG, Bauza GJ, Mella JR, Remick DG: Pathophysiologic mechanisms in septic shock, Lab Invest 2014, 94:4-12, PMID: 24061288

23. Craciun FL, Iskander KN, Chiswick EL, Stepien DM, Henderson JM, Remick DG: Early murine polymicrobial sepsis predominantly causes renal injury, Shock 2014, 41:97-103, PMID: 24300829

24. Bauza G, Moitra R, Remick D: Adenosine receptor antagonists effect on plasma-enhanced killing, Shock 2014, 41:62-66, PMID: 24089004

25. Yang SH, Gustafson J, Gangidine M, Stepien D, Schuster R, Pritts TA, Goodman MD, Remick DG, Lentsch AB: A murine model of mild traumatic brain injury exhibiting cognitive and motor deficits, J Surg Res 2013, 184:981-988, PMID: 23622728


26. Natarajan S, Remick DG: ELISA rescue protocol: recovery of sample concentrations from an assay with an unsuccessful standard curve, Methods 2013, 61:69-72, PMID: 22982520

27. Beal DR, Stepien DM, Natarajan S, Kim J, Remick DG: Reduction of eotaxin production and eosinophil recruitment by pulmonary autologous macrophage transfer in a cockroach allergen-induced asthma model, Am J Physiol Lung Cell Mol Physiol 2013, 305:L866-877, PMID: 24077949

28. Iskander KN, Osuchowski MF, Stearns-Kurosawa DJ, Kurosawa S, Stepien D, Valentine C, Remick DG: Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding, Physiol Rev 2013, 93:1247-1288, PMID: 23899564

29. Bouchard JC, Beal DR, Kim J, Vaickus LJ, Remick DG: Chemokines mediate ethanol-induced exacerbations of murine cockroach allergen asthma, Clin Exp Immunol 2013, 172:203-216, PMID: 23574317

30. Ahyi AN, Quinton LJ, Jones MR, Ferrari JD, Pepper-Cunningham ZA, Mella JR, Remick DG, Mizgerd JP: Roles of STAT3 in protein secretion pathways during the acute-phase response, Infect Immun 2013, 81:1644-1653, PMID: 23460517

31. Barth K, Remick DG, Genco CA: Disruption of immune regulation by microbial pathogens and resulting chronic inflammation, J Cell Physiol 2013, PMID 23255141

32. Finnerty CC, Jeschke MG, Qian WJ, Kaushal A, Xiao W, Liu T, Gritsenko MA, Moore RJ, Camp DG, 2nd, Moldawer LL, Elson C, Schoenfeld D, Gamelli R, Gibran N, Klein M, Arnoldo B, Remick D, Smith RD, Davis R, Tompkins RG, Herndon DN: Determination of burn patient outcome by large-scale quantitative discovery proteomics, Crit Care Med 2013, 41:1421-1434 PMID 23507713

33. Iskander KN, Craciun FL, Stepien DM, Duffy ER, Kim J, Moitra R, Vaickus LJ, Osuchowski MF, Remick DG: Cecal ligation and puncture-induced murine sepsis does not cause lung injury*, Crit Care Med 2013, 41:154-165, PMID: 3531667

34. Osuchowski MF, Craciun F, Weixelbaumer KM, Duffy ER, Remick DG: Sepsis Chronically in MARS: Systemic Cytokine Responses Are Always Mixed Regardless of the Outcome, Magnitude, or Phase of Sepsis, J Immunol 2012, 189:4648-4656, PMID: 3478412

35. Natarajan S, Remick DG: ELISA rescue protocol: Recovery of sample concentrations from an assay with an unsuccessful standard curve, Methods 2012, PMID:

36. Belikoff BG, Vaickus LJ, Sitkovsky M, Remick DG: A2B adenosine receptor expression by myeloid cells is proinflammatory in murine allergic-airway inflammation, J Immunol 2012, 189:3707-3713, PMID: 3448803

37. Richmond JM, Duffy ER, Lee J, Kaboli K, Remick DG, Kornfeld H, Cruikshank WW: Mannose-Capped Lipoarabinomannan from Mycobacterium tuberculosis Induces Soluble Tumor Necrosis Factor Receptor Production through Tumor Necrosis Factor Alpha-Converting Enzyme Activation, Infection and immunity 2012, 80:3858-3868, PMID: 348603

38. Vaickus LJ, Bouchard J, Kim J, Natarajan S, Remick DG: Cockroach allergens induce biphasic asthma-like pulmonary inflammation in outbred mice, The Journal of Asthma 2012, 49:510-521, PMID: 22540923

39. Bouchard JC, Kim J, Beal DR, Vaickus LJ, Craciun FL, Remick DG: Acute oral ethanol exposure triggers asthma in cockroach allergen-sensitized mice, Am J Pathol 2012, 181:845-857, PMID: 22796441

40. Winfield RD, Delano MJ, Cuenca AG, Cendan JC, Lottenberg L, Efron PA, Maier RV, Remick DG, Moldawer LL, Cuschieri J: Obese Patients Show a Depressed Cytokine Profile Following Severe Blunt Injury, Shock 2012, PMID: 22266966


41. Natarajan S, Kim J, Bouchard J, Cruikshank W, Remick DG: Pulmonary Endotoxin Tolerance Protects against Cockroach Allergen-Induced Asthma-Like Inflammation in a Mouse Model, Int Arch Allergy Immunol 2012, 158:120-130, PMID: 22269653

42. Moitra R, Beal DR, Belikoff BG, Remick DG: Presence of preexisting antibodies mediates survival in sepsis, Shock 2012, 37:56-62, PMID: 21921828

43. Chiswick EL, Duffy E, Japp B, Remick D: Detection and quantification of cytokines and other biomarkers, Methods Mol Biol 2012, 844:15-30, PMID: 22262432

44. Kim J, Natarajan S, Vaickus LJ, Bouchard JC, Beal D, Cruikshank WW, Remick DG: Diesel exhaust particulates exacerbate asthma-like inflammation by increasing CXC chemokines, Am J Pathol 2011, 179:2730-2739, PMID: 21967814

45. Asimaki A, Tandri H, Duffy ER, Winterfield JR, Mackey-Bojack S, Picken MM, Cooper LT, Wilber DJ, Marcus FI, Basso C, Thiene G, Tsatsopoulou A, Protonotarios N, Stevenson WG, McKenna WJ, Gautam S, Remick DG, Calkins H, Saffitz JE: Altered desmosomal proteins in granulomatous myocarditis and potential pathogenic links to arrhythmogenic right ventricular cardiomyopathy, Circ Arrhythm Electrophysiol 2011, 4:743-752, PMID: 21859801

46. Kong X, Thimmulappa R, Craciun F, Harvey C, Singh A, Kombairaju P, Reddy SP, Remick D, Biswal S: Enhancing Nrf2 Pathway by Disruption of Keap1 in Myeloid Leukocytes Protects Against Sepsis, Am J Respir Crit Care Med 2011, PMID: 21799073

47. Kim J, Natarajan S, Bae H, Jung SK, Cruikshank W, Remick DG: Herbal medicine treatment reduces inflammation in a murine model of cockroach allergen-induced asthma, Ann Allergy Asthma Immunol 2011, 107:154-162, PMID: 21802024

48. Belikoff B, Hatfield S, Sitkovsky M, Remick DG: Adenosine Negative Feedback on A2A Adenosine Receptors Mediates Hyporesponsiveness in Chronically Septic Mice, Shock 2011, 35:382-387, PMID: 21192284

49. Belikoff BG, Hatfield S, Georgiev P, Ohta A, Lukashev D, Buras JA, Remick DG, Sitkovsky M: A2B adenosine receptor blockade enhances macrophage-mediated bacterial phagocytosis and improves polymicrobial sepsis survival in mice, J Immunol 2011, 186:2444-2453, PMID: 21242513

50. Natarajan S, Kim J, Bouchard J, Cruikshank W, Remick DG: Reducing LPS content in cockroach allergens increases pulmonary cytokine production without increasing inflammation: A randomized laboratory study, BMC Pulm Med 2011, 11:12, PMID: 21345191

51. Stearns-Kurosawa DJ, Osuchowski MF, Valentine C, Kurosawa S, Remick DG: The Pathogenesis of Sepsis, Annu Rev Pathol 2011, 6:19-48, PMID: 20887193

52. Vaickus LJ, Bouchard J, Kim J, Natarajan S, Remick DG: Inbred and outbred mice have equivalent variability in a cockroach allergen-induced model of asthma, Comp Med 2010, 60:420-426, PMID: 21262127

53. Craciun FL, Schuller ER, Remick DG: Early enhanced local neutrophil recruitment in peritonitis-induced sepsis improves bacterial clearance and survival, J Immunol 2010, 185:6930-6938, PMID: 21041722

54. Vaickus LJ, Bouchard J, Kim J, Natarajan S, Remick DG: Oral Tolerance Inhibits Pulmonary Eosinophilia in a Cockroach Allergen Induced Model of Asthma: A Randomized Laboratory Study, Respir Res 2010, 11:160, PMID: 21092270

55. Vaickus LJ, Bouchard J, Kim J, Natarajan S, Remick DG: Assessing pulmonary pathology by detailed examination of respiratory function, Am J Pathol 2010, 177:1861-1869, PMID: 20724595

56. Uddin J, Gonzalez AE, Gilman RH, Thomas LH, Rodriguez S, Evans CA, Remick DG, Garcia HH, Friedland JS: Mechanisms regulating monocyte CXCL8 secretion in neurocysticercosis and the effect of antiparasitic therapy, J Immunol 2010, 185:4478-4484, PMID: 20826750


57. Osuchowski MF, Craciun FL, Schuller E, Sima C, Gyurko R, Remick DG: Untreated type 1 diabetes increases sepsis-induced mortality without inducing a prelethal cytokine response, Shock 2010, 34:369-376, PMID: 20610941

58. Natarajan S, Kim J, Remick DG: Chronic pulmonary LPS tolerance induces selective immunosuppression while maintaining the neutrophilic response, Shock 2010, 33:162-169, PMID: 19487981

59. Cuschieri J, Bulger E, Schaeffer V, Sakr S, Nathens AB, Hennessy L, Minei J, Moore EE, O'Keefe G, Sperry J, Remick D, Tompkins R, Maier RV: Early Elevation in Random Plasma Il-6 after Severe Injury Is Associated with Development of Organ Failure, Shock 2010, 34:346-351, PMID: 20844410

60. Zhou B, Xu W, Herndon D, Tompkins R, Davis R, Xiao W, Wong WH, Toner M, Warren HS, Schoenfeld DA, Rahme L, McDonald-Smith GP, Hayden D, Mason P, Fagan S, Yu YM, Cobb JP, Remick DG, Mannick JA, Lederer JA, Gamelli RL, Silver GM, West MA, Shapiro MB, Smith R, Camp DG, 2nd, Qian W, Storey J, Mindrinos M, Tibshirani R, Lowry S, Calvano S, Chaudry I, Cohen M, Moore EE, Johnson J, Moldawer LL, Baker HV, Efron PA, Balis UG, Billiar TR, Ochoa JB, Sperry JL, Miller-Graziano CL, De AK, Bankey PE, Finnerty CC, Jeschke MG, Minei JP, Arnoldo BD, Hunt JL, Horton J, Brownstein B, Freeman B, Maier RV, Nathens AB, Cuschieri J, Gibran N, Klein M, O'Keefe G: Analysis of factorial time-course microarrays with application to a clinical study of burn injury, Proc Natl Acad Sci U S A 2010, 107:9923-9928, PMID: 20479259

61. Draganov D, Teiber J, Watson C, Bisgaier C, Nemzek J, Remick D, Standiford T, La Du B: PON1 and Oxidative Stress in Human Sepsis and an Animal Model of Sepsis, Adv Exp Med Biol 2010, 660:89-97, PMID: 20221873

62. Horton DL, Remick DG: Delayed addition of glucocorticoids selectively suppresses cytokine production in stimulated human whole blood, Clin Vaccine Immunol 2010, 17:979-985 PMID: 20445007

63. Rosenzweig M, Seldin DC, Remick DG, Skinner M, Quillen K, Oran B, Finn KT, Sanchorawala V: Febrile reactions occurring with second cycle of high-dose melphalan and SCT in patients with AL amyloidosis: a 'melphalan recall' reaction, Bone Marrow Transplant 2010, 45:21-24, PMID: 19421171

64. Osuchowski MF, Teener J, Remick D: Noninvasive model of sciatic nerve conduction in healthy and septic mice: reliability and normative data, Muscle Nerve 2009, 40:610-616, PMID: 19618431

65. Osuchowski MF, Connett J, Welch K, Granger J, Remick DG: Stratification is the key: inflammatory biomarkers accurately direct immunomodulatory therapy in experimental sepsis, Crit Care Med 2009, 37:1567-1573, PMID: 19325479.

66. Minter RM, Bi X, Ben-Josef G, Wang T, Hu B, Arbabi S, Hemmila MR, Wang SC, Remick DG, Su GL: LPS-binding protein mediates LPS-induced liver injury and mortality in the setting of biliary obstruction. Am J Physiol Gastrointest Liver Physiol 2009, 296:G45-54, PMID: 18948440.

67. Natarajan S, Kim J, Remick DG: Acute pulmonary lipopolysaccharide tolerance decreases TNF-alpha without reducing neutrophil recruitment. J Immunol 2008, 181:8402-8408.

68. Sperry JL, Friese RS, Frankel HL, West MA, Cuschieri J, Moore EE, Harbrecht BG, Peitzman AB, Billiar TR, Maier RV, Remick DG, Minei JP: Male gender is associated with excessive IL-6 expression following severe injury, J Trauma 2008, 64:572-578, PMID: 18332795.

69. Natarajan S, Remick DG: The ELISA Standard Save: Calculation of sample concentrations in assays with a failed standard curve, J Immunol Methods 2008, 336:242-245.

70. Finnerty CC, Jeschke MG, Herndon DN, Gamelli R, Gibran N, Klein M, Silver G, Arnoldo B, Remick D, Tompkins RG: Temporal Cytokine Profiles In Severely Burned Patients: A Comparison Of Adults And Children, Mol Med 2008, 1076-1551


71. Ipaktchi K, Mattar A, Niederbichler AD, Kim J, Hoesel LM, Hemmila MR, Su GL, Remick DG, Wang SC, Arbabi S: Attenuating burn wound inflammation improves pulmonary function and survival in a burn-pneumonia model, Crit Care Med 2007, 35:2139-2144.

72. Xing L, Remick DG: Promoter elements responsible for antioxidant regulation of MCP-1 gene expression, Antioxid Redox Signal 2007, 9:1979-1989 PMID 17949278.

73. Kim J, Remick DG: Tumor necrosis factor inhibitors for the treatment of asthma, Curr Allergy Asthma Rep 2007, 7:151-156

74. Remick DG: Pathophysiology of sepsis, Am J Pathol 2007, 170:1435-1444: PMID: 17456750 75. Xing L, Remick DG: Mechanisms Of Oxidant Regulation Of Monocyte Chemotactic Protein 1

Production In Human Whole Blood And Isolated Mononuclear Cells, Shock 2007, 28:178-85 76. Osuchowski MF, Welch K, Yang H, Siddiqui J, Remick DG: Chronic sepsis mortality

characterized by an individualized inflammatory response, J Immunol 2007, 179:623-630 77. Ipaktchi K, Mattar A, Niederbichler AD, Hoesel LM, Hemmila MR, Su GL, Remick DG, Wang

SC, Arbabi S: Topical p38MAPK inhibition reduces dermal inflammation and epithelial apoptosis in burn wounds, Shock 2006, 26:201-209

78. Hemmila MR, Kim J, Sun JM, Cannon J, Arbabi S, Minter RM, Su GL, Remick DG, Wang SC: Gene therapy with lipopolysaccharide binding protein for gram-negative pneumonia: respiratory physiology, J Trauma 2006, 61:598-605; discussion 605-596, PMID: 16966994

79. Ipaktchi K, Mattar A, Niederbichler AD, Hoesel LM, Vollmannshauser S, Hemmila MR, Su GL, Remick DG, Wang SC, Arbabi S: Attenuating burn wound inflammatory signaling reduces systemic inflammation and acute lung injury, J Immunol 2006, 177:8065-8071

80. Osuchowski MF, Welch K, Siddiqui J, Remick DG: Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality, J Immunol 2006, 177:1967-1974 PMID 16849510.

81. McKinley L, Kim J, Bolgos GL, Siddiqui J, Remick DG: Allergens induce enhanced bronchoconstriction and leukotriene production in C5 deficient mice, Respir Res 2006, 7:129

82. Xiao H, Siddiqui J, Remick DG: Mechanisms of mortality in early and late sepsis, Infect Immun 2006, 74:5227-5235.

83. Brownstein, B.H., Logvinenko, T., Lederer, J.A., Cobb, J.P., Hubbard, W.J., Chaudry, I.H., Remick, D.G., Baker, H.V., Xiao, W., and Mannick, J.A. 2006. Commonality and differences in leukocyte gene expression patterns among three models of inflammation and injury. Physiol Genomics 24:298-309.

84. Osuchowski, M.F., and Remick, D.G. 2006. The repetitive use of samples to measure multiple cytokines: The sequential ELISA. Methods 38:304-311.

85. Kim J, McKinley L, Natarajan S, Bolgos GL, Siddiqui J, Copeland S, Remick DG. 2006. Anti-tumor necrosis factor-alpha antibody treatment reduces pulmonary inflammation and methacholine hyper-responsiveness in a murine asthma model induced by house dust. Clin Exp Allergy 36(1):122-132.

86. Remick, D.G., Xioa, H. 2006. Hypothermia and sepsis. Front Biosci Jan 1;11:1006-13. 87. Granger, J., J. Siddiqui, S. Copeland, and D. Remick. 2005. Albumin depletion of human plasma

also removes low abundance proteins including the cytokines. Proteomics 5(18):4713-8. 88. Scumpia, P. O., P. F. McAuliffe, K. A. O'Malley, R. Ungaro, T. Uchida, T. Matsumoto, D. G.

Remick, M. J. Clare-Salzler, L. L. Moldawer, and P. A. Efron. 2005. CD11c+ dendritic cells are required for survival in murine polymicrobial sepsis. J Immunol 175(5):3282-6.

89. Minter, R. M., M. H. Fan, J. Sun, A. Niederbichler, K. Ipaktchi, S. Arbabi, M. R. Hemmila, D. G. Remick, S. C. Wang, and G. L. Su. 2005. Altered Kupffer cell function in biliary obstruction. Surgery 138(2):236-45.


90. Granger, J., and D. Remick. 2005. Acute pancreatitis: models, markers, and mediators. Shock 24 Suppl 1:45-51

91. Remick, D.G., Ward P.A. 2005. Evaluation of endotoxin models for the study of sepsis. Shock, Dec;24 Suppl 1:7-11.

92. McKinley, L., J. Kim, G. L. Bolgos, J. Siddiqui, and D. G. Remick. 2005. CXC chemokines modulate IgE secretion and pulmonary inflammation in a model of allergic asthma. Cytokine 32(3-4):178-85.

93. Steinstraesser, L., O. Burkhard, M. H. Fan, F. Jacobsen, M. Lehnhardt, G. Su, A. Daigler, H. U. Steinau, D. Remick, and S. C. Wang. 2005. Burn wounds infected with Pseudomonas aeruginosa triggers weight loss in rats. BMC Surg 5:19.

94. El-Sawy, T., J. A. Belperio, R. M. Strieter, D. G. Remick & R. L. Fairchild. 2005. Inhibition of polymorphonuclear leukocyte-mediated graft damage synergizes with short-term costimulatory blockade to prevent cardiac allograft rejection. Circulation, 112, 320-31.

95. De A.K, Miller-Graziano C.L., Calvano, S.E., Laudanski, K., Lowry, S.F., Moldawer L.L., Remick, D.G., Rajicic N., Schoenfeld D., Tompkins R.G. 2005. Selective activation of peripheral blood T cell subsets by endotoxin infusion in healthy human subjects corresponds to differential chemokine activation. J Immunol, 1;175(9):6155-62.

96. Hemmila, M. R., M. H. Fan, J. Kim, J. M. Sun, L. Steinstraesser, K. Q. Gong, S. Arbabi, R. M. Minter, D. G. Remick, G. L. Su & S. C. Wang. 2005. Improved survival in mice given systemic gene therapy in a gram negative pneumonia model. J Trauma, 58, 1110-8; discussion 1118.

97. Osuchowski, M. F., J. Siddiqui, S. Copeland & D. G. Remick. 2005. Sequential ELISA to profile multiple cytokines from small volumes. J Immunol Methods, 302, 172-81.

98. Remick, D. G., G. Bolgos, S. Copeland & J. Siddiqui. 2005. Role of interleukin-6 in mortality from and physiologic response to sepsis. Infect Immun, 73, 2751-7.

99. Xing, L., Remick, D.G., 2005 Mechanisms of dimethyl sulfoxide augmentation of IL-1 beta production. J Immunol, 174, 6195-202.

100. Zeng, X. K., Y. F. Guan, D. G. Remick & X. Wang. 2005. Signal pathways underlying homocysteine-induced production of MCP-1 and IL-8 in cultured human whole blood. Acta Pharmacol Sin, 26:85-91

101. Copeland, S., H. S. Warren, S. F. Lowry, S. E. Calvano, and D. Remick. 2005. Acute inflammatory response to endotoxin in mice and humans. Clin Diagn Lab Immunol 12:60-67.

102. Cobb, J. P., M. N. Mindrinos, C. Miller-Graziano, S. E. Calvano, H. V. Baker, W. Xiao, K. Laudanski, B. H. Brownstein, C. M. Elson, D. L. Hayden, D. N. Herndon, S. F. Lowry, R. V. Maier, D. A. Schoenfeld, L. L. Moldawer, R. W. Davis, R. G. Tompkins, H. V. Baker, P. Bankey, T. Billiar, B. H. Brownstein, S. E. Calvano, D. Camp, I. Chaudry, J. P. Cobb, R. W. Davis, C. M. Elson, B. Freeman, R. Gamelli, N. Gibran, B. Harbrecht, D. L. Hayden, W. Heagy, D. Heimbach, D. N. Herndon, J. Horton, J. Hunt, K. Laudanski, J. Lederer, S. F. Lowry, R. V. Maier, J. Mannick, B. McKinley, C. Miller-Graziano, M. N. Mindrinos, J. Minei, L. L. Moldawer, E. Moore, F. Moore, R. Munford, A. Nathens, G. O'Keefe, G. Purdue, L. Rahme, D. Remick, M. Sailors, D. A. Schoenfeld, M. Shapiro, G. Silver, R. Smith, G. Stephanopoulos, G. Stormo, R. G. Tompkins, M. Toner, S. Warren, M. West, S. Wolfe, W. Xiao, and V. Young. 2005. Application of genome-wide expression analysis to human health and disease. Proc Natl Acad Sci U S A 102:4801-4806

103. Su, G. L., K. Q. Gong, M. H. Fan, W. M. Kelley, J. Hsieh, J. M. Sun, M. R. Hemmila, S. Arbabi, D. G. Remick, and S. C. Wang. 2005. Lipopolysaccharide-binding protein modulates acetaminophen-induced liver injury in mice. Hepatology 41:187-195.

104. Xiao, H., and D. G. Remick. 2005. Correction of perioperative hypothermia decreases experimental sepsis mortality by modulating the inflammatory response. Crit Care Med 33:161-167.


105. Zeng, X. K., Y. F. Guan, D. G. Remick, and X. Wang. 2005. Signal pathways underlying homocysteine-induced production of MCP-1 and IL-8 in cultured human whole blood. Acta Pharmacol Sin 26:85-91.

106. Kim, J., L. McKinley, J. Siddiqui, G. L. Bolgos, and D. G. Remick. 2004. Prevention and reversal of pulmonary inflammation and airway hyperresponsiveness by dexamethasone treatment in a murine model of asthma induced by house dust. Am J Physiol Lung Cell Mol Physiol 287:L503-509.

107. Xing, L., Remick, D.G. 2004. Neutrophils as firemen, production of anti-inflammatory mediators by neutrophils in a mixed cell environment. Cell Immunol Sep-Oct; 231(1-2):126-32.

108. Zeng, X. K., D. G. Remick, and X. Wang. 2004. Homocysteine induces production of monocyte chemoattractant protein-1 and interleukin-8 in cultured human whole blood. Acta Pharmacol Sin 25:1419-1425.

109. Nemzek, JA, Xiao HY, Minard AE, Bolgos GL, Remick DG. 2004. Humane endpoints in shock research. Shock 21: 17-25.

110. Xiao, H, Kovics R, Jackson V, Remick DG. 2004. Effects of platelet inhibitors on propyl gallate-induced platelet aggregation, protein tyrosine phosphorylation, and platelet factor 3 activation. Blood Coagul Fibrinolysis 15: 199-206.

111. Woodford, NL, Call DR, Remick DG, Rochford R. 2004. Model of angiogenesis in mice with severe combined immunodeficiency (SCID) and xenoengrafted with Epstein-Barr virus-transformed B cells. Comp Med 54: 209-15.

112. McKinley, L, Kim J, Bolgos GL, Siddiqui J, Remick DG. 2004. Reproducibility of a novel model of murine asthma-like pulmonary inflammation. Clin Exp Immunol 136: 224-31.

113. Knight, PR, Sreekumar A, Siddiqui J, Laxman B, Copeland S, Chinnaiyan A, Remick DG. 2004. Development of a sensitive microarray immunoassay and comparison with standard enzyme-linked immunoassay for cytokine analysis. Shock 21: 26-30.

114. Hirano, S, Rees RS, Yancy SL, Welsh MJ, Remick DG, Yamada T, Hata J, Gilmont RR. 2004. Endothelial barrier dysfunction caused by LPS correlates with phosphorylation of HSP27 in vivo. Cell Biol Toxicol 20: 1-14.

115. Copeland, S, Siddiqui J, Remick D. 2004. Direct comparison of traditional ELISAs and membrane protein arrays for detection and quantification of human cytokines. J Immunol Methods 284: 99-106.

116. Remick DG, Bolgos GE, Siddiqui J. 2003. Inflammatory status in sepsis alters efficacy of interleukin-18 binding protein therapy. Crit Care Med 31: 2096-101.

117. Trout, D, Weissman DN, Lewis D, Brundage RA, Franzblau A, Remick D. 2003. Evaluation of hypersensitivity pneumonitis among workers exposed to metal removal fluids. Appl Occup Environ Hyg 18: 953-60.

118. Siddiqui, J, Remick DG. 2003. Improved sensitivity of colorimetric compared to chemiluminescence ELISAs for cytokine assays. J Immunoassay Immunochem 24: 273-83.

119. Xing, L., and Remick, D.G. 2003. Relative cytokine and cytokine inhibitor production by mononuclear cells and neutrophils. Shock 20:10-16.

120. Zeng, X., Dai, J., Remick, D.G., and Wang, X. 2003. Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes. Circ Res 93:311-320.

121. Steinstraesser, L., Burghard, O., Nemzek, J., Fan, M.H., Merry, A., Remick, D.G., Su, G.L., Steinau, H.U., and Wang, S.C. 2003. Protegrin-1 increases bacterial clearance in sepsis but decreases survival. Crit Care Med 31:221-226.

122. Remick, D.G. 2003. Cytokine therapeutics for the treatment of sepsis: why has nothing worked? Curr Pharm Des 9:75-82.


123. Wang, X., S. J. Ebong, D. R. Call, D. E. Newcomb, G. R. Bolgos, and D. G. Remick. Calcitonin gene-related peptide partially reverses decreased production of chemokines KC and MIP-2 following murine sepsis. Inflammation 2002:26, 167-74.

124. Fan, M. H., R. D. Klein, L. Steinstraesser, A. C. Merry, J. A. Nemzek, D. G. Remick, S. C. Wang, and G. L. Su. An essential role for lipopolysaccharide-binding protein in pulmonary innate immune responses. Shock 2002:18, 248-254.

125. Nemzek, J. A., S. J. Ebong, J. Kim, G. L. Bolgos, and D. G. Remick. Keratinocyte growth factor pretreatment is associated with decreased macrophage inflammatory protein-2alpha concentrations and reduced neutrophil recruitment in acid aspiration lung injury. Shock 2002:18,501-6.

126. Su GL, Goyert SM, Fan MH, Aminlari A, Gong KQ, Klein RD, Myc A, Alarcon WH, Steinstraesser L, Remick DG, Wang SC: Activation of human and mouse Kupffer cells by lipopolysaccharide is mediated by CD14. American Journal of Physiology Gastrointestinal & Liver Physiology 2002, 283.

127. Xiao H, Jepkorir CJ, Harvey K, Remick DG: Thrombin-induced platelet microparticles improved the aggregability of cryopreserved platelets. Cryobiology 2002, 44:179-188.

128. Remick DG, Bolgos GR, Siddiqui J, Shin J, Nemzek JA: Six at six: interleukin-6 measured 6 h after the initiation of sepsis predicts mortality over 3 days. Shock 2002, 17:463-467 PMID 12069181.

129. Steinstraesser L, Tack BF, Waring AJ, Hong T, Boo LM, Fan MH, Remick DG, Su GL, Lehrer RI, Wang SC: Activity of novispirin G10 against Pseudomonas aeruginosa in vitro and in infected burns. Antimicrob Agents Chemother 2002, 46:1837-1844.

130. Kim J, Merry AC, Nemzek JA, Bolgos GL, Siddiqui J, Remick DG: Eotaxin Represents the Principal Eosinophil Chemoattractant in a Novel Murine Asthma Model Induced by House Dust Containing Cockroach Allergens. J Immunol 2001, 167(5):2808-2815 PMID 11509626.

131. Miura M, Fu X, Zhang QW, Remick DG, Fairchild RL: Neutralization of Gro alpha and macrophage inflammatory protein-2 attenuates renal ischemia/reperfusion injury. Am J Pathol 2001, 159:2137-2145.

132. Moon SE, Dame MK, Remick DG, Elder JT, Varani J: Induction of matrix metalloproteinase-1 (MMP-1) during epidermal invasion of the stroma in human skin organ culture: keratinocyte stimulation of fibroblast MMP-1 production. Br J Cancer 2001, 85:1600-1605.

133. Steinstraesser L, Fohn M, Klein RD, Aminlari A, Remick DG, Su GL, Wang SC. Feasibility of biolistic gene therapy in burns. Shock 2001, 15:272-7.

134. 97.Steinstraesser L, Klein RD, Aminlari A, Fan MH, Khilanani V, Remick DG, Su GL, Wang SC. Protegrin-1 enhances bacterial killing in thermally injured skin. Crit Care Med 2001, 29:1431-7.

135. Mosher B, Dean R, Harkema J, Remick D, Palma J, Crockett E. Inhibition of Kupffer cells reduced CXC chemokine production and liver injury. J Surg Res 2001, 99:201-10.

136. Nemzek JA, Siddiqui J, Remick DG. Development and optimization of cytokine ELISAs using commercial antibody pairs. J Immunol Methods 2001, 255:149-57.

137. Stern SA, Wang X, Mertz M, Chowanski ZP, Remick DG, Kim HM, Dronen SC. Under-resuscitation of near-lethal uncontrolled hemorrhage: effects on mortality and end-organ function at 72 hours. Shock 2001, 15:16-23.

138. Ebong SJ, Goyert SM, Nemzek JA, Kim J, Bolgos GL, Remick DG. Critical role of CD14 for production of proinflammatory cytokines and cytokine inhibitors during sepsis with failure to alter morbidity or mortality. Infection & Immunity 2001, 69:2099-106.


139. Nemzek, J.A., Bolgos, G.L., Williams, B.A., and Remick, D.G. 2001. Differences in normal values for murine white blood cell counts and other hematological parameters based on sampling site. Inflammation Research 50:523-527.

140. Call DR, Nemzek JA, Ebong SJ, Bolgos GR, Newcomb DE, Wollenberg GK, Remick DG. Differential local and systemic regulation of the murine chemokines KC and MIP2. Shock 2001, 4:278-284.

141. Call DR, Nemzek JA, Ebong SJ, Bolgos GR, Newcomb DE, Remick DG. Ratio of local to systemic chemokine concentrations regulates neutrophil recruitment. American Journal of Pathology 2001, 158:715-721.

142. Remick DG, Call DR, Ebong SJ, Newcomb DE, Nybom P, Nemzek JA, Bolgos GE. Combination immunotherapy with soluble tumor necrosis factor receptors plus interleukin 1 receptor antagonist decreases sepsis mortality. Critical Care Medicine 2001, 29:473-481.

143. De Plaen IG, Tan XD, Chang H, Wang L, Remick DG, Hsueh W: Lipopolysaccharide activates nuclear factor kappaB in rat intestine: role of endogenous platelet-activating factor and tumour necrosis factor. Br J Pharmacol 2000, 129:307-314.

144. Call DR, Jacoby M, Rudolph KM, Bolgos GL, Robbins CT, Remick DG: Detecting Wildlife Orthologues for Tumor Necrosis Factor (TNF) and Interleukin 6 (IL-6). Northwest Science 74:240-345, 2000

145. Kronfol Z, Remick D.G: Cytokines and the Brain: Implications for Clinical Psychiatry. Am J Psychiatry 2000, 157: 683-694 PMID 10784457

146. Remick, D. G., D. E. Newcomb, G. L. Bolgos, and D. R. Call. Comparison of the mortality and inflammatory response of two models of sepsis: lipopolysaccharide vs. cecal ligation and puncture 2000, Shock. 13:110-6 PMID 10670840.

147. Nemzek, J. A., D. R. Call, S. J. Ebong, D. E. Newcomb, G. L. Bolgos, and D. G. Remick. Immunopathology of a two-hit murine model of acid aspiration lung injury American Journal of Physiology; Lung Cellular and Molecular Physiology. 2000, 278:L512-L520.

148. Su, G.L., R.D. Klein, A. Aminlari, H. Y. Zhang, L. Steinstraesser, W.H. Alarcon, D.G. Remick, and S.C. Wang. Kupffer cell activation by lipopolysaccharide in rats: role for lipopolysaccharide binding protein and toll-like receptor 4 Hepatology. 2000, 31:932-6.

149. Cooper, P. J., D. Fekade, D. G. Remick, P. Grint, J. Wherry, and G. E. Griffin. Recombinant human interleukin-10 fails to alter proinflammatory cytokine production or physiologic changes associated with the Jarisch-Herxheimer reaction J Infect Dis. 2000, 181:203-9.

150. Nemzek, J.A., Newcomb, D.E., Call, D.R., Remick, D.G. Plasma interference in an enzyme-linked immunosorbant assay using a commercial matched antibody pair. Immunological Investigations 1999, 28: 209-21.

151. Ebong, S.J., Call, D.R., Bolgos, G.L., Newcomb, D.E., Granger, J.I., O'Reilly, M., Remick, D.G. Immunopathologic responses to non-lethal sepsis. Shock 1999, 12:118-126.

152. Granger, J., Remick, D., Call, D., Ebong, S., Taur, A., Williams, B., Nauss, M., Millican, J., O'Reilly, M. A sandwich enzyme-linked immunoabsorbent assay for measurement of picogram quantities of murine granulocyte colony-stimulating factor. Journal of Immunological Methods 1999, 225:145-56.

153. Hennein, H.A., Kiziltepe, U., Barst, S., Bocchieri, K.A., Hossain, A., Call, D.R., Remick, D.G., Gold, J.P. Venovenous modified ultrafiltration after cardiopulmonary bypass in children: a prospective randomized study. Journal of Thoracic & Cardiovascular Surgery 1999, 117:496-505.

154. Cooper, P.J., Awadzi, K., Ottesen, E.A., Remick, D., Nutman, T.B. Eosinophil sequestration and activation are associated with the onset and severity of systemic adverse reactions following the treatment of onchocerciasis with ivermectin. Journal of Infectious Diseases 1999, 179:738-42.


155. Evans, C.A., Jellis, J., Hughes, S.P., Remick, D.G., Friedland, J.S. Tumor necrosis factor-alpha, interleukin-6, and interleukin-8 secretion and the acute-phase response in patients with bacterial and tuberculous osteomyelitis. Journal of Infectious Diseases 1998, 177:1582-7.

156. Call, DR and Remick, DG. Low molecular weight heparin is associated with greater cytokine production in a stimulated whole blood model, Shock, 1998 10:192-197.

157. Newcomb, D, Bolgos, G, Green, L, and Remick DG, Antibiotic treatment influences outcome in murine sepsis: mediators of increased morbidity, Shock, 1998, 10:110-117.

158. Remick DG, Garg SJ, Newcomb DE, Huie TK, Bolgos GL. Exogenous interleukin 10 fails to decrease the mortality or morbidity of sepsis Crit Care Med 1998, 26:895 – 904.

159. Hunter B, French D, Warner J, Remick D. Correlation of body mass index with thoracic and abdominal Am. J. Forensic Sciences, 1998, 43:427-30.

160. Shanley TP, Foreback JL, Remick DG, Ulich TR, Kunkel SL, Ward PA. Regulatory effects of interleukin 6 in immunoglobulin G immune-complex-induced lung injury. Am. J. Path. 1997, 151:193-203.

161. Wang H, Tan X, Chang H, Gonzalez-Crussi F, Remick DG, Hsueh W. Regulation of platelet-activating factor receptor gene expression in vivo by endotoxin, platelet-activating factor and endogenous tumour necrosis factor. Biochem J 1997; 322 ( Pt 2):603-608.

162. Villarete LH, Remick DG. Nitric oxide regulation of interleukin-8 gene expression. Shock 1997; 7:29-35.

163. Zhang K, Gharaee-Kermani M, McGarry B, Remick DG, Phan SH. TNF-alpha-mediated lung cytokine networking and eosinophil recruitment in pulmonary fibrosis. J Immunol 1997; 158:954-959.

164. Gilmont RR, Dardano A, Engle JS, Adamson BS, Welsh MJ, Li T Remick, DG, Smith DJ and Rees RS. TNF-alpha potentiates oxidant and reperfusion-induced endothelial cell injury. J Surg Res 1996; 61:175-182.

165. Yi ES, Remick DG, Lim Y, Tang W, Nadzienko CE, Bedoya A, Yin S, Ulich TR. The intratracheal administration of endotoxin: X. Dexamethasone downregulates neutrophil emigration and cytokine expression in vivo. Inflammation 1996; 20:165-175.

166. Yi ES, Bedoya A, Lee H, Chin E, Saunders W, Kim SJ, Danielpour D, Remick D., Yin S, Ulich TR. Radiation-induced lung injury in vivo: expression of transforming growth factor-beta precedes fibrosis. Inflammation 1996; 20:339-352.

167. Friedland JS, Porter JC, Daryanani S, Bland JM, Screaton NJ, Vesely MJ, Bennet ED and Remick, DG. Plasma proinflammatory cytokine concentrations, Acute Physiology and Chronic Health Evaluation (APACHE) III scores and survival in patients in an intensive care unit. Crit Care Med 1996; 24:1775-1781.

168. Cooper PJ, Guderian RH, Prakash D, Remick DG, Espinel I, Nutman TB, Griffin G. RANTES in onchocerciasis: changes with ivermectin treatment. Clin Exp Immunol 1996; 106:462-467.

169. Yi ES, Lee H, Suh YK, Tang W, Qi M, Yin S, Remick, DG, Ulich TR.. Experimental extrinsic allergic alveolitis and pulmonary angiitis induced by intratracheal or intravenous challenge with Corynebacterium parvum in sensitized rats. Am J Pathol 1996; 149:1303-1312.

170. Villarete LH, Remick DG. Transcriptional and post-transcriptional regulation of interleukin-8. Am J Pathol 1996; 149:1685-1693 PMID 8909257.

171. Remick DG, Negussie Y, Fekade D, Griffin G. Pentoxifylline fails to prevent the Jarisch-Herxheimer reaction or associated cytokine release. J Infect Dis 1996; 174:627-630.

172. Balazovich KJ, Suchard SJ, Remick DG, Boxer LA. Tumor necrosis factor-alpha and FMLP receptors are functionally linked during FMLP-stimulated activation of adherent human neutrophils. Blood 1996; 88:690-696.


173. Remick DG, Villarete LH Regulation of cytokine gene expression by reactive oxygen and reactive nitrogen intermediates. J Leukoc Biol 1996; 59:471-5.

174. Tang WW, Yi ES, Remick DG, Wittwer A, Yin S, Qi M, Ulich TR: Intratracheal injection of endotoxi and cytokine. IX Contribution of CD11a/ICAM-1 to neutrophil emigration. Am. J. Physiol. 1995 L653-L659.

175. Remick DG: Cytokines: a primer for plastic surgeons. Ann Plast Surg 1995; 35:549-59. 176. Biswas S, Friedland JS, Remick DG, Davies EG, Sharland M: Elevated plasma interleukin

8 in respiratory syncytial virus bronchiolitis. Pediatr Infect Dis J 1995; 14:919.140. 177. Villarete, L.H. and D.G. Remick: Nitric oxide regulation of IL-8 expression in human

endothelial cells. Biochem. Biophys. Res. Commun. 1995; 211:671-676. 178. Ulich, T.R., S.C. Howard, D.G. Remick, A. Wittwer, E.S. Yi, S. Yin, K. Guo, J.K. Welply,

and J.H. Williams: Intratracheal administration of endotoxin and cytokines. VI Antiserum to CINC inhibits acute inflammation. Am. J. Physiol. 1995; 268:L245-50.

179. Rogy, M.A., T. Auffenberg, N.J. Espat, R. Philip, D. Remick, G.K. Wollenberg, E.M. Copeland, III, L.L. Moldawer, and E. M. Copeland: Human tumor necrosis factor receptor (p55) and interleukin-10 gene transfer in the mouse reduces mortality to lethal endotoxemia and also attenuates local inflammatory responses. J. Exp. Med. 1995; 181:2289-2293.

180. Remick, D.G., P. Manohar, G. Bolgos, J. Rodriguez, L. Moldawer, and G. Wollenberg: Blockade of tumor necrosis factor reduces lipopolysaccharide lethality, but not the lethality of cecal ligation and puncture. Shock. 1995; 4:89-95.

181. Olson, A.D., E.A. DelBuono, K.N. Bitar, and D.G. Remick: Anti-serum to tumor necrosis factor and failure to prevent murine colitis. J.Pediatr. Gastroenterol. Nutr. 1995; 21:410-418.

182. Hsi, E. and D.G. Remick: Monocytes are the major producers of interleukin-1 beta in an ex vivo model of local cytokine production. J. Interferon. Cytokine. Res. 1995; 15:89-94.

183. Brieland, J.K., D.G. Remick, P.T. Freeman, M.C. Hurley, J.C. Fantone, and N.C. Engleberg: In vivo regulation of replicative Legionella pneumophila lung infection by endogenous tumor necrosis factor alpha and nitric oxide. Infect. Immun. 1995; 63:3253-3258.

184. Brieland, J.K., C.M. Flory, M.L. Jones, G.R. Miller, D.G. Remick, J.S. Warren, and J.C. Fantone: Regulation of monocyte chemoattractant protein-1 gene expression and secretion in rat pulmonary alveolar macrophages by lipopolysaccharide, tumor necrosis factor-alpha, and interleukin-1 beta. Am. J. Respir. Cell Mol. Biol. 1995; 12:104-109.

185. Ulich, T.R., S.C. Howard, D.G. Remick, E.S. Yi, T. Collins, K. Guo, S. Yin, J.L. Keene, J.J. Schumke, C.N. Steininger, and et al: Intratracheal administration of endotoxin and cytokines: VIII. LPS induces E-selectin expression; anti-E-selectin and soluble E-selectin inhibit acute inflammation. Inflammation 1994; 18: 389-398.

186. Ulich, T.R., M.J. Fann, P.H. Patterson, J.H. Williams, B. Samal, J. del Castillo, S. Yin, K. Guo, and D.G. Remick: Intratracheal injection of LPS and cytokines. V. LPS induces expression of LIF and LIF inhibits acute inflammation. Am. J. Physiol. 1994; 267: L442-6.

187. Scales, W.E., D.A. Campbell, Jr., M.E. Green, and D.G. Remick: Hepatic ischemia/reperfusion injury: importance of oxidant/tumor necrosis factor interactions. Am. J. Physiol. 1994; 267:G1122-7.106.

188. Waage, A., Remick, D.G., Steinshamm, S., DeForge, L., and Lamvik, J. Interleukin-8 in serum in granulocytopenic patients with infections. British Hournal of Haematology 1994;86:36-40.

189. Remick, D.G., Colletti, L.M., Scales, W.A., McCurry, K.R., and Campbell, D.A., Jr., Cytokines and extrahepatic sequelae of ischemia-reperfusion injury to the liver. Ann.N.Y.Acad.Sci. 1994;723:271-283.

190. Remick, D.G. Cytokines and septic shock. Clinical Infectious Diseases 1994;1:37-50.


191. Griffin, G.E., Negussie, Y., Fekade, D., Morlese, J., Forrester, T., and Remick, D.G. The Jarisch-Herxheimer reaction:a paradigm of the cytokine cascade in man. Clinical Infectious Diseases 1994;1:65-74.

192. Garner, W.L., Rodriguez, J.L., Miller, C.G., Till, G.O., Rees, R.S., Smith, D.J. and Remick, D.G. Acute skin injury releases neutrophil chemoattractants. Surgery 1994;116:42-48.

193. Doherty, J.F., Golden, M.H., Remick, D.G. and Griffin, G.e. Production of interleukin-6 and tumour necrosis factor-alpha in vitro is reduced in whole blood of severely malnourished children. Clin.Sci(Colch). 1994;86:347-351.

194. DeForge, L.E., Takeuchi, E., Nguyen, D.T., and Remick, D.G. Immunological priming attenuates the in vivo pathophysiological response to lipopolysaccharide. Comparison of cytokine production, tissue injury, and lethality in complete Freund's adjuvant-primed mice and in unprimed mice. Am.J.Pathol. 1994; 144:599-611.

195. Colletti, L.M., Remick, D.G., and Campbell, D.A., Jr. LPS pretreatment protects from hepatic ischemia/reperfusion. J.Surg.Res. 1994;57:337-334.

196. Saravolatz, L.D., Wherry, J.C., Spooner, C., Markowitz, N., Allred, R., Remick, D., Fournel, M., and Pennington, J.E.: Clinical safety, tolerability, and pharmacytokinetics of murine monoclonal antibody to human tumor necrosis factor-α. J. Infec. Dis., 1994; 169:214-217.

197. Colletti, L.M., Remick, D.G., Kunkel, S.L., and Campbell, D.A.. Jr.: Desferal, protects against the pulmonary and hepatic injury following hepatic ischemia/reperfusion and attenuates TNF release. J. Surg. Res .1994; 57:447-53.

198. Remick, D.G.: Lung and gut injury induced by tumour necrosis factor. Res. in Immunol. 1993; 144:326-331.

199. McCurry, K.R., Campbell, D.A. Jr., Warren, J.S., Scales, W.E., and Remick, D.G.: TNF, IL-6 and the acute phase response following hepatic ischemia/reperfusion. J. Surg. Res. 1993; 54:49-54.

200. DeForge, L.E., Preston, A.M., Takeuchi, E., Kenney, J., Boxer, L.A., and Remick, D.G.: Regulation of interleukin 8 gene expression by oxidant stress. J. Biol. Chem. 1993; 268:12-13 PMID 8244994.

201. Wollenberg, G.K., DeForge, L.E., Bolgos, G., and Remick, D.G.: Differential expression of tumor necrosis factor and interleukin-6 by peritoneal macrophages in vivo and in culture. Am. J. Pathol. 1993; 143:1121-1130.

202. Seekamp, A., Warren, J.S., Remick, D.G., Till, G.O., and Ward, P.A.: Requirements for tumor necrosis factor-alpha and interleukin-1 in limb ischemia/reperfusion injury and associated lung injury. Am. J. Pathol .1993; 143:453-463.

203. Hsi, E.D. and Remick, D.G.: Rapid determination of cell-associated tumor necrosis factor by flow cytometry. Lab. Invest. 1993; 69:740-745.

204. Ulich, T.R., Yin, S., Remick, D.G., Russell, D., Eisenberg, S.P., and Kohno, T.: Intratracheal administration of endotoxin and cytokines. IV. The soluble tumor necrosis factor receptor type I inhibits acute inflammation. Am. J. Pathol., 1993; 142:1335-1338.

205. Tait, A.R., Davidson, B.A., Johnson, K.J., Remick, D.G., and Knight P.R.: Halothane inhibits the intra-alveolar recruitment of neutrophils, lymphocytes, and macrophages in response to influenza virus infection in mice. Anesth. Analg. 1993; 76:1106-1113.

206. Rodriguez, J.L., Miller, C.G., Garner, W.L., Till, G.O., Guerrero, P., Moore, N.P., Corridore, M., Normolle, D.P., Smith, D.J., and Remick, D.G.: Correlation of the local and systemic cytokine response with clinical outcome following thermal injury. J. Trauma 1993; 34:684-694; Discussion 694-695.

207. Lelli, J.L., Drongowski, R.A., Gastman, B., Remick, D.G., and Coran, A.G.: Effects of coenzyme Q10 on the mediator cascade of sepsis. Cir. Res. 1993; 39:178-187.


208. Friedland, J.S., Ho, M., Remick, D.G., Bunnag, D., White, N.J., and Griffin, G.E.: Interleukin-8 and Plasmodium falciparum malaria in Thailand. Trans. R. Soc. Trop. Med. Hyg. 1993; 87:54-55.

209. Atluru, D., Hansen, J., Remick, D.G., O'Donnell, M.P. Kasiske, B.L., and Keane, W.F.: Effects of cyclosporin A, FK-506 and Genistein on IL-6, IL-8 production and gene expression by human mononuclear cells. Biochem. Arch. 1993; 147-155.

210. Remick, D.G. and Kunkel, S.L.: Pathophysiologic alterations induced by tumor necrosis factor. Int. Rev. Exp. Pathol. 1993; 34B:7-25.

211. Karmiol, S., D.G. Remick, S.L. Kunkel, and S.H. Phan: Regulation of rat pulmonary endothelial cell interleukin-6 production by bleomycin: effects of cellular fatty acid composition. Am. J. Respir. Cell Mol. Biol. 1993; 9:628-636.

212. Friedland, J.S., Shattaock, R., Remick, D.G. and Griffin, G.E.: Mycobacterial 65 kD heat shock protein induces release of proinflammatory cytokines from human monocytic cells. Clin. Exp. Immunol., 1993; 91:58-62.

213. Friedland, J.S., Shattock, R.J., Johnson, J.D., Remick, D.G, Holliman, R.E., and Griffin, G.E.: Differential cytokine gene expression and secretion after phagocytosis by a human monocyte cell line of Toxoplasma gondii compared with Mycobacterium tuberculosis. Clin. Exp. Immunol., 1993; 91:282-286.

214. Rodriguez, J.L., Miller, C.G., DeForge, L.E., Kelty, L., Shanley, C., Bartlett, R.H., and Remick, D.G.: Local production of interleukin-8 is associated with nosocomial pneumonia. J. Trauma. 1992; 33:74-81.

215. DeForge, L.E., Fantone, J.C., Kenney J.S., and Remick, D.G.: Oxygen radical scavengers selectively inhibit interleukin-8 production in human whole blood. J. Clin. Invest., 1992; 90:2123-2129 PMID 1331181.

216. Friedland, J.S., Remick, D.G., Shattuck, R., and Griffin, G.E.: Secretion of interleukin-8 following phagocytosis of Mycobacterium tuberculosis by human monocyte cell lines. Eur. J. Immunol., 1992; 1373-1378.

217. Coran, A.G., Drongowski, R.A., Paik, J.J., and Remick, D.G.: Ibuprofen intervention in canine septic shock: Reduction of pathophysiology without decreased cytokines. J. Surg. Res., 1992; 53:272-279.

218. Remick, D.G., DeForge, L.E., Sullivan, J.F., and Showell, H.J.: Profile of cytokines in synovial fluid specimens from patients with arthritis. Immunol. Invest., 1992; 321-327.

219. Sharma, R.J., Macallan, D.C., Sedgwick, P., Remick, D.G., and Griffin, G.E.: Kinetics of endotoxin-induced acute-phase protein gene expression and its modulation by TNF-alpha monoclonal antibody. Am. J. Physiol. 1992; 262:R786-R793.

220. Negussie, Y., Remick, D.G., DeForge, L.E., Kunkel, S.L., Eynon, A., and Griffin, G.E.: Detection of plasma tumor necrosis factor, interleukins 6, and 8 during the Jarisch-Herxheimer Reaction of relapsing fever. J. Exp. Med. 1992; 175:1207-1212.

221. Lin, H., Chensue, S.W., Strieter, R.M., Remick, D.G., Gallagher, K.P., Bolling, S.F., and Kunkel, S.L.: Antibodies against tumor necrosis factor prolong cardiac allograft survival in the rat. J. Heart Lung Transplant 1992; 11:330-335.

222. Friedland, J.S., Suputtamongkol, Y., Remick, D.G., Chaowagul, W., Strieter, R.M., Kunkel, S.L., White, N.J., and Griffin, G.E.: Prolonged elevation of interleukin-8 and interleukin-6 concentrations in plasma and of leukocyte interleukin-8 mRNA levels during septicemic and localized Pseudomonas pseudomallei infection. Infect. Immun. 1992; 60:2402-2408.

223. Fischer E, Marano, M.A., Van Zee, K.J., Rock, C.S., Hawes, A.S., Thompson, W.A., DeForge, L., Kenney, J.S., Remick, D.G., Bloedow, D.C., Thompson, R.C., Lowry, S.F., and Moldawer, L.L.: Interleukin-1 receptor blockade improves survival and hemodynamic performance


in E. coli septic shock, but fails to alter host responses to sublethal endotoxemia. J. Clin. Invest., 1992; 89:1551-1557.

224. Eskandari, M.K., Bolgos, G., Miller, C., Nguyen, D.T., DeForge, L.E., and Remick, D.G.: Anti-tumor necrosis factor antibody therapy fails to prevent lethality after cecal ligation and puncture for endotoxemia. J. Immunol. 1992; 148:2724-2730 PMID 1315357.

225. DeForge, L.E., Kenney, J.S., Jones, M.L., Warren, J.S., and Remick, D.G.: Biphasic production of IL-8 in lipopolysaccharide (LPS)-stimulated human whole blood. Separation of LPS- and cytokine-stimulated components using anti-tumor necrosis factor and anti-IL-1 antibodies. J. Immunol. 1992; 148:2133-2141.

226. DeForge, L.E., Tracey, D.E., Kenney, J.S., and Remick, D.G.: Interleukin-1 receptor antagonist protein inhibits interleukin-8 expression in lipopolysaccharide-stimulated human whole blood. Am. J. Pathol. 1992; 140:1045-1054.

227. Guice, K.S., Oldham, K.T., Remick, D.G., Kunkel, S.L., and Ward, P.A.: Anti-tumor necrosis factor antibody augments edema formation in caerulin-induced acute pancreatitis. J. Surg. Res. 1991; 51:495-499.

228. Martin, L.F., Vary, T.C., Davis, P.K., Munger, B.L., Lynch, J.C., Spangler, S., and Remick, D.G.: Intravascular plastic catheters. How they potentiate tumor necrosis factor release and exacerbate complications associated with sepsis. Arch. Surg. 1991; 126:1087-1093.

229. Ulich, T.R., Yin, S., Guo, K., Yi, E.S., Remick, D.G., and del Castillo, J.: Intratracheal injection of endotoxin and cytokines. II. Interleukin-6 and transforming growth factor beta inhibit acute inflammation. Am. J. Pathol. 1991; 138:1097-1101.

230. Van Zee, K.J., DeForge, L.E., Fischer, E., Marano, M.A., Kenney, J.S., Remick, D.G., Lowry, S.F., and Moldawer, L.: IL-8 in septic shock, endotoxemia, and after IL-1 administration. J. Immunol. 1991; 146:3478-3482.

231. Kunkel, S.L., Strieter, R.M. Chensue, S.W., Campbell, D.A. Jr., and Remick, D.G.: The role of TNF in diverse pathologic processes. Biotherapy. 1991; 3:135-141.

232. Caty, M.G., Guice, K.S., Oldham, K.T., Remick, D.G., and Kunkel, S.L.: Evidence for TNF-related pulmonary microvascular injury following intestinal ischemia-reperfusion injury. Ann. Surg. 1991; 212:694-700.

233. Elner, V.M., R.M. Streiter, M.A. Pavilack, S.G. Elner, D.G. Remick, J.M. Danforth, and S.L. Kunkel: Human corneal interleukin-8. IL-1 and TNF-induced gene expression and secretion. Am. J. Pathol. 139:977-988, 1991.

234. Wharram, B.L., Fitting, K., Kunkel, S.L., Remick, D.G., Merritt, S.E., and Wiggins, R.C.: Tissue factor expression in endothelial cell/monocyte co-cultures stimulated by lipopolysaccharide and/or aggregated IgG. Mechanisms of cell:cell communication. J. Immunol. 1991; 146:1437-1445.

235. Chensue, S.W., Terebuh, P.D., Remick, D.G., Scales, W.E., and Kunkel, S.L.: In vivo biologic and immunohistochemical analysis of interleukin-1a,b and tumor necrosis factor during experimental endotoxemia. Kinetics, Kupffer cell expression, and glucocorticoid effects. Am. J. Pathol. 1991; 138:395-402.

236. Ulich, T.R., Guo, K., Remick, D., del Castillo, J., and Yin, S.: Endotoxin-induced cytokine gene expression in vivo. J. Immunol. 1991; 146:2316-2323.

237. DeForge, L.E., and Remick, D.G.: Sandwich ELISA for detection of picogram quantities of interleukin-8. Immun. Invest. 1991; 20:89-97.

238. DeForge, L.E. and Remick, D.G.: Kinetics of TNF, IL-6, and IL-8 gene expression in LPS-stimulated human whole blood. Biochem. Biophys. Res. Commun. 1991; 174:18-24.

239. Eskandari, M.K., Nguyen, D.T., Kunkel, S.L., and Remick, D.G.: WEHI 164 Subclone 13 assay for TNF: Sensitivity, Specificity, and Reliability. Immuno. Invest. 1990; 19:69-79.


240. Ulich, T.R., Guo, K.Z., Irwin, B., Remick, D.G., and Davatelis, G.N.: Endotoxin-induced cytokine gene expression in vivo: II: Regulation of tumor necrosis factor and interleukin-1a,b expression and suppression. Am. J. Pathol. 1990; 137:1173-1185.

241. Kunkel, S.L., Strieter, R.M., Chensue, S.W., Basha, M., Standiford, T., Ham, J., and Remick, D.G.: Tumor necrosis factor-alpha, interleukin-2, and chemotactic cytokines. Prog. Clin. Biol. Res. 1990; 349:433-44.

242. Colletti, L.M., Remick, D.G., Burtch, G.D., Kunkel, S.L., Strieter, R.M., and Campbell, D.A. Jr.: The role of tumor necrosis factor-a in the pathophysiologic alterations following hepatic ischemia/reperfusion injury in the rat. J. Clin. Invest. 1990; 85:1936-43 PMID 2161433.

243. DeForge, L.E., Nguyen, D.T., Kunkel, S.L., and Remick, D.G.: Regulation of the pathophysiology of tumor necrosis factor. J. Lab. Clin. Med. 1990; 116:429-38.

244. Nguyen, D.T., Eskandari, M.K., DeForge, L.E., Raiford, C.L., Strieter, R.M., Kunkel, S.L., and Remick, D.G.: Cyclosporin A modulation of tumor necrosis factor gene expression and effects in vitro and in vivo. J. Immunol. 1990; 144:3822-08.

245. Spengler, R.N., Allen, R.M., Remick, D.G., Strieter, R.M., and Kunkel, S.L.: Stimulation of alpha-adrenergic receptor augments the production of macrophage-derived tumor necrosis factor. J. Immunol. 1990; 145:1430-4.

246. Strieter, R.M., Remick, D.G., Ham, J.M., Colletti, L.M., Lynch, J.P. III, and Kunkel, S.L.: Tumor necrosis factor-alpha gene expression in human whole blood. J. Leuk. Biol. 1990; 47:366-70.

247. Colletti, L.M., Burtch, G.D., Remick, D.G., Kunkel, S.L., Strieter, R.M., Guice, K.S., Oldham, K.T., and Campbell, D.A.: Production of tumor necrosis factor-a and the development of capillary injury following hepatic ischemia/reperfusion. Transplantation 1990; 49:268-272.

248. Kunkel, S.L., Chensue, S.W., Strieter, R.M., Lynch, J.P., and Remick, D.G.: Cellular and molecular aspects of granuloma formation. Am. J. Respir. Cell. Molec. Biol. 1989; 1:439-447.

249. Bagavandoss, P., Wiggins, R.C., Kunkel, S.L., Remick, D.G., and Keyes, P.L.: Tumor necrosis factor production and accumulation of inflammatory cells in the corpus luteum of pseudopregnancy and pregnancy in rabbits. Biol. Reprod. 1990; 42:367-376.

250. Remick, D.G., Strieter, R.M., Eskandari, M.K., Nguyen, D.T., Genord, M.A., Raiford, C.L., and Kunkel, S.L.: Role of tumor necrosis factor-a in lipopolysaccharide-induced pathologic alterations. Am. J. Pathol. 1990; 136:46-60.

251. Remick, D.G., Kunkel,S.L., Holbrook, E.A., and Hanson, C.A.: Theory and applications of the polymerase chain reaction. Am. J. Clin. Pathol. 1990; 93:549-553.

252. Strieter, R.M., Remick, D.G., Lynch, J.P., III, and Kunkel, S.L.: The role of tumor necrosis factor-alpha (TNF) in multiple organ injury: A cellular and molecular analysis. Chest 1989; 95(Suppl):233S-234S.

253. Warren, J.S., Yabroff, K.R., Remick, D.G., Kunkel, S.L., Kunkel, R.G., Johnson, K.J., and Ward, P.A.: Tumor necrosis factor participates in the pathogenesis of acute immune complex alveolitis in the rat. J. Clin. Invest. 1989; 84:1873-1882.

254. Podrazik, R.M., Obedian, R.S., Remick, D.G., Zelenock, G.B., and D'Lacey, L.G.: Attenuation of structural and functional damage from acute renal ischemia by the 21-amino steroid U74006F in rats. Current Surgery 1989; 46:287-292.

255. Davis, P.K., Remick, D.G., Parascandola, S.A., Spangler, S., Wise, R.K., and Martin, L.F.: Intravascular plastic catheters potentiate tumor necrosis factor release and cardiac dysfunction secondary to infection. Current Surgery 1989; 46:486-489.

256. Spengler, R.N., Spengler, M., Lincoln, P., Remick, D.G., Strieter, R.M., and Kunkel, S.L.: Dynamics of dibutyryl cyclic AMP and prostaglandin E2-mediated suppression of


lipopolysaccharide-induced tumor necrosis factor-a gene expression. Infect. Immun. 1989; 57:2837-2841.

257. Strieter, R.M., Phan, S.H., Showell, H.J., Remick, D.G., Lynch, J.P., Genord, M., Raiford, C., Eskandari, M., Marks, R.M., Kunkel, S.L.: Monokine-induced neutrophil chemotactic factor gene expression in human fibroblasts. J. Biol. Chem. 1989; 264:10621-10626.

258. Strieter, R.M., Wiggins, R., Phan, S.H., Wharram, B.L., Showell, H.J., Remick, D.G., Chensue, S.W., and Kunkel, S.L.: Monocyte chemotactic protein gene expression by cytokine-treated human fibroblasts and endothelial cells. Biochem. Biophys. Res. Commun. 1989; 162:694-700.

259. Remick, D.G., Strieter, R.M., Lynch, J.P. III, Nguyen, D., Eskandari, M. and Kunkel, S.L.: In vivo dynamics of murine tumor necrosis factor-a gene expression: Kinetics of dexamethasone-induced suppression. Lab. Invest. 1989; 60:766-771.

260. Strieter, R.M., Remick, D.G., Lynch, J., III, Kunkel, S.L.: Differential regulation of tumor necrosis factor-alpha in human alveolar macrophages and peripheral blood monocytes: A cellular and molecular analysis. Respir. Cell and Mole. Biol. 1:57-63, 1989.

261. Spengler, R.N., Spengler, M.L., Strieter, R.M., Remick, D.G., Larrick, J.W., and Kunkel, S.L.: Modulation of tumor necrosis factor-alpha gene expression: Desensitization of prostaglandin E2-induced suppression. J. Immunol. 142:4346-4350, 1989.

262. Remick, D.G., Nguyen, D.T., Eskandari, M.K., Strieter, R.M., and Kunkel, S.L.: Cyclosporine A inhibits TNF production without decreasing TNF mRNA levels. Biochem. Biophys. Res. Commun. 161:551-555, 1989.

263. Eskandari, M.K., Kunkel, S.L., and Remick, D.G.: Effects of arachidonic acid metabolites and other compounds on the CTLL assay for interleukin-2. J. Immunol. Meth. 118:85-89, 1989

264. Strieter, R.M., Kunkel, S.L., Showell, H.J., Remick, D.G., Phan, S.H., Ward, P.A., and Marks, R.M.: Endothelial cell gene expression of a neutrophil chemotactic factor by TNF-a, LPS, and IL-1b. Science 243:1467-1469, 1989 PMID 2648570.

265. Kunkel, S.L. and Remick, D.G.: Toxic effects of cytokines in vivo. Lab. Invest. 60:317-319, 1989.

266. Strieter, R.M., Remick, D.G., Lynch, J.P., Spengler, R.N., and Kunkel, S.L.: Interleukin-2 induced tumor necrosis factor-alpha (TNF) gene expression in human alveolar macrophages and blood monocytes. Am. Rev. Respir. Dis. 139:335-342, 1989.

267. Chensue, S.W., Remick, D.G., Shmyr-Forsch, C., Beals, T., and Kunkel, S.L.: Immunohistochemical demonstration of cytoplasmic and membrane-associated tumor necrosis factor in murine macrophages. Am. J. Pathol. 133:564-572, 1988.

268. Remick, D.G., Scales, W.E., May, M.A., Spengler, M., Nguyen, D., and Kunkel, S.L.: In situ hybridization analysis of macrophage-derived tumor necrosis factor and interleukin-2 mRNA. Lab. Invest. 59:809-816, 1988.

269. Strieter, R.M., Remick, D.G., Ward, P.A., Spengler, R.N., Lynch, J.P., III, Larrick, J., and Kunkel, S.L.: Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxifylline. Biochem. Biophys. Res. Commun. 1988; 155:1230-1236.

270. Kunkel, S.L., Spengler, M., May, M., Spengler, R.S., Larrick, J.W., and Remick, D.G.: Prostaglandin E regulates macrophage-derived tumor necrosis factor gene expression. J. Biol. Chem., 1988; 263:5380-5384 PMID 3162731.

271. Remick, D.G., Kunkel S.L., Higashi, G.I., and Hiserodt, J.C.: Specific suppression of natural killer cell cytolytic activity in mice undergoing pulmonary granulomatous inflammation. J. Immunol., 1988; 140:2225-2230.


272. Kunkel, S.L., M. Spengler, G. Kwon, M.A. May, and D.G. Remick: Production and regulation of tumor necrosis factor alpha. A cellular and molecular analysis. Methods.Achiev.Exp.Pathol. 1988; 13:240-259.

273. Remick, D.G., Chensue, S.W., Hiserodt, J.C., Higashi, G.I., and Kunkel, S.L.: Flow cytometric evaluation of lymphocyte subpopulations in synchronously developing Schistosoma mansoni egg and Sephadex bead pulmonary granulomas. Am. J. Pathol. 1988; 131:298-307.

274. Remick, D.G., Larrick, J.W., Nugyen, D.T., and Kunkel, K.L.: Stimulation of prostaglandin E2 and thromboxane B2 production by human monocytes in response to interleukin-2. Biochem. Biophys. Res. Commun. 1987; 147:86-93.

275. Remick, D.G., Larrick, J., and Kunkel, S.L.: Acute in vivo effects of recombinant tumor necrosis factor. Lab. Invest. 1987; 56:583-590 PMID 3599906.

276. Remick, D.G., Larrick, J., and Kunkel, S.L.: Tumor necrosis factor-induced alterations in circulating leukocyte populations. Biochem. Biophys. Res. Commun. 1986; 141:818-824.

277. Chensue, S.W., Remick, D.G., Higashi, G.I., Boros, D.L. , and Kunkel, S.L.: Modulation of murine Schistosomiasis mansoni by exogenously administered prostaglandins. Am. J. Pathol. 1986; 125:28-34.

278. Chensue, S.W., Davey, M.P., Remick, D.G., and Kunkel, S.L.: Release of interleukin 1 by peripheral blood mononuclear cells in patients with tuberculosis and active inflammation states. Infect. & Immun. 1986; 52:341-343.

279. Remick, D.G. and Kumar, N.B.: Benign polyps with prostatic type epithelium of the urethra and the urinary bladder: A suggestion of histogenesis based on histologic and immunohistochemical studies. Am. J. Surg. Path. 1984; 8:333-840.

280. Remick, D.G. and Flint, A.: Metastatic squamous cell carcinoma: Diagnosis by synovial fluid aspiration. Acta Cytologica. 1984; 28:776-777.

281. Remick, D.G. and Oberman, H.A.: Rabies: Treatment and Diagnosis. American Society of Clinical Pathologists Check Sample, Anatomic Pathology, 1984; AP 84-2:1-6.

CASE REPORTS, REVIEWS, CHAPTERS AND EDITORIALS Reviews and Book Chapters

1. Remick, D.G. L. Villarete, and DeForge, L.E.: Oxidant regulation of cytokine gene expression in Clerch, L.B and Massaro, D.J (eds) Oxygen, Gene Expression and Cellular Function Marcel Dekker, Inc, 1997, 243 - 278.

2. Remick, D. G. and DeForge, L.E.: Cytokines and pulmonary fibrosis. In, Phan, S.H. and Thrall, R.S. (eds). Pulmonary Fibrosis, Marcel Dekker, Inc.., 1995, 599-615.

3. Remick, D.G.: Macrophage-derived cytokines. In, van Oss, C. J. and van Regenmortel, M.H. (eds). Immunochemistry, Marcel Dekker, Inc., 1994, 995-1017.

4. Eskandari, M.K. and Remick, D.G.: Quantitation of the biological activities of cytokines. In, Kunkel, S.L. and Remick, D.G. (eds). Cytokines in Health and Disease, Marcel Dekker, Inc., 1992; 1-14.

5. Colletti, L.M., Remick, D.G., Burtch, G.D., Strieter, R.M., Kunkel, S.L., and Campbell, D.A.: The role of TNF in local and systemic organ injury following hepatic ischemia/reperfusion. In, Dinarello, C.A., Kluger, M.J., Powanda, M.C., Oppenheim, J.J. (eds). The Physiological and Pathological Effects of Cytokines, Wiley-Liss, Inc., pp. 207-212, 1990.

6. Ward, P.A. and Remick, D.G.: The role of immune mechanisms in lung injury. In, A.P. Fishman (Ed.) Pulmonary Disease and Disorders, McGraw-Hill Publishers, New York, New York, pp. 607-619, 1989.


7. W.E., Strieter, R.M., Chensue, S.W., Spengler, R.N., and Remick, D.G.: Modulation of tumor necrosis factor-a and interleukin-1 gene expression. In, Otterness, I., (Ed.) The Therapeutic Control of Inflammatory Diseases, Elsevier, New York, New York, 1989.

8. Kunkel, S.L., Strieter, R.M., Chensue, S.W., and Remick, D.G.: Regulation of tumor necrosis factor and neutrophil activating protein-1 gene expression: Potential role of cytokine-directed cell communication during multiple organ injury. In, Brigham, K., and Stalhman, M. (Eds.) Respiratory Distress Syndrome: Molecules to Man, Vanderbilt Press, Nashville, TN, 1989.

9. Remick, D.G., Scales, W.E., Chensue, S.W., and Kunkel, S.L.: The pathophysiology of interleukins and tumor necrosis factors. In, Sayeed, M. (ed.) Focus on Cellular Pathophysiology, Vol. I, CRC Press Inc., Boca Raton, Florida, pp 41-89, 1989.

10. Ward, P.A., Warren, J.S., Remick, D.G., Varani, J., Gannon, D., and Johnson, K.J.: Cytokines and oxygen radical-mediated tissue injury. Chapter 6, In Biharia, D.J. and Cerra, F.B. (eds) New Horizons: Multiple Organ Failure, Society of Critical Care Medicine, pp 93-100, 1989.

11. Kunkel, S.L., Remick, D.G., Spengler, M., and Chensue, S.W.: Modulation of macrophage-derived interleukin-1 and tumor necrosis factor by prostaglandin E2. In, B. Samuelsson, R. Paoletti, and P.W. Ramwell (Eds.) Advances in Prostaglandin, Thromboxane, and Leukotriene Research, Raven Press, New York, New York, 1987.

Editorials and Critical Reviews

Non-peer reviewed published work (Editorials etc.) 1. Remick D: Use of animal models for the study of human disease-a shock society debate, Shock

2013, 40:345-346, PMID: 24045419 2. Remick D: What's new in shock? August 2013, Shock 2013, 40:79-80, PMID: 23860580 3. Remick D, Duffy J: Editorial for "cytokine methods", Methods 2013, 61:1-2, PMID: 23764649 4. Remick DG: Let the treatment fit the disease, Crit Care Med 2011, 39:1549-1550, PMID:

21610616 5. Remick D.G.: Old friends: pneumonia and interleukin-6, Crit Care Med 2009, 37:1809-1810 6. Remick D.G.: What's new in Shock, February 2009? Shock 2009, 31:111-112 7. Remick D. G. 2008. What's new in Shock, May 2008? Shock 29:541-542 8. Remick D. G. 2008. What's new in Shock, July 2008? Shock 30:1-2 9. Remick, D. G. 2006. What's new in Shock, April 2006? Shock 25:319-320 10. Remick, D. G. 2005. What's new in Shock, November 2005. Shock 24(5):405-6. 11. Remick, D. G. 2005. What's new in shock, December 2005. Shock 24(6):503-4. 12. Remick, D. G. 2005. Interleukin-8. Crit Care Med 33(12 Suppl):S466-7 13. Remick, D. G. 2004. Do not get sick when you are sick: the impact of comorbid conditions. Crit

Care Med 32(10):2147-8 14. Remick, D.G.: Significance of in vivo detection of tumor necrosis factor. Lab. Invest. (Editorial)

1991; 65:259-261 15. Remick, D.G., W.E. Scales, S.W. Chensue, and S.L. Kunkel: The pathophysiology of interleukins

and tumor necrosis factors. In.M.Sayeed (ed):Cellular Pathophysiology. Boca Raton, FL: CRC Press. 41-89, 1989.

16. Kunkel, S.L., Remick, D.G., Strieter, R.M., and Larrick, J.W.: Mechanisms that regulate the production and effects of tumor necrosis factor-alpha. CRC Reviews in Immunology, 9:93-117, 1989. Other (Electronic programs, Web-based articles, etc.) Chairman’s Blog – an ongoing blog about pathology.


http://www.bumc.bu.edu/busm-pathology/chairmans-blog Textbook Chapters: Books Edited 1. Remick, D.G. and Friedland, J.F. (eds) Cytokines in Health and Disease, Second Edition Revised

and expanded, Marcel Dekker, Inc. 1997. 2. Kunkel, S.L. and Remick, D.G. (eds). Cytokines in Health and Disease, Marcel Dekker, Inc.,

1992.

curriculum vitae daniel g. remick, md 617-414 …...daniel remick, m.d., cv november 2018 curriculum...

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