curriculum vitae -carlo gaetano-november_18th_ 2015_new

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Goethe‐Universität Frankfurt am Main

Medizinische Klinik III: Kardiologie,

Angiologie/Hämostaseologie,

Nephrologie

Division of Cardiovascular Epigenetics,

Bldg 25B, 5th floor, Room 549‐549

Theodor‐Stern‐Kai 7

Hessen, 60896

Germany

[email protected]

[email protected]‐frankfurt.de

Married to: Antonella Farsetti‐Gaetano

Two sons: Massimo Gaetano, born in 1993;

Rodolfo Gaetano, born in 1999.

Current family address: Bertha von Suttner Ring 22

60598, Frankfurt am Main, Germany.

Phone (home): 0049 (69) 26093285

Phone (work): 0049 (69) 630187963

Mobile: +491733273839

Fax: 0049 (0) 69 630185277

Website: www.researchgate.net/profile/Carlo_Gaetano

Prof. Carlo Gaetano M.D, FAHA. http://www.cgt‐frankfurt.de/CGTEN/Research/Verzeichnis040/Verzeichnis107/

https://www.researchgate.net/profile/Carlo_Gaetano

Education

Nov 1981 – Oct 1986 Sapienza University of Rome

Degree in Medicine, Immunology

Rome, Italy

Jan 1988 – Mar 1992 Sapienza University of Rome

Specialization in Clinical Pathology

Rome, Italy

Research Experience

Nov 1980 – Oct 1986 Student (Medicine)

Università degli Studi di Roma ʺLa Sapienzaʺ,

Rome, Italy

Jan 1989 – Jan 1992 PostDoc Position

NIH/National Cancer Institute, Bethesda, USA.

Jan 1992 – Jun 1995 PostDoc Position

Istituto Regina Elena ‐ Istituti Fisioterapici Ospitalieri,

Rome, Italy

Jun 1995 – Oct 1996 Visiting Scientist

NIH/National Cancer Institute ,

Bethesda, USA.

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Aug 1999 – Aug 2000 Visiting Associate Professor

McMaster University, Hamilton (ON), CA

Nov 1996 – Apr 2012 Senior Researcher

Istituto Dermopatico dellʹImmacolata,

Rome, Italy

Jan 2005 – Dec 2011 Consultant, Centro Cardiologico Monzino, Milan, Italy

Jun 2012 – present

Associate (W2) Professor of Stem Cells Biology

Director, Division of Cardiovascular Epigenetics, Medizinische Klinik III:

Kardiologie, Angiologie/Hämostaseologie, Nephrologie, Göethe‐Universität,

Frankfurt am Main, Germany

Metrics

RG Score 41.71

Publications 120

Total Impact Points 715.15

Views 12k

Downloads 5000

Citations 3424

H index 34

i10 index 63

Awards & Grants

AWARDS

Dec 1986 Award: ʺAnna Villa‐Rusconiʺ fellowship

Jan 1989 Award: Pasteur Cenci‐Bolognetti fellowship

Jan 1990 Award: Fogarty International fellowship (USA)

Jan 1992 Award: Associazione Italiana Ricerca sul Cancro fellowship

Jun 1995 Award: National Cancer Institute Visiting Scientist fellowship (USA)

GRANTS (last three years)

Jun 2012‐Jun 2017 Core Grant from the State of Hessen (DE) in the context of a Research

Excellence Initiative. Project title: “Development of a Cardiovascular

Epigenetics Research Platform”. PI: Prof. Carlo Gaetano. Amount granted :

$ 1.650.000

Jan 2013‐ Jan 2014 Grant from the Cell and Gene Therapy Center (CGT) Frankfurt. Project title

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“Identification of functional long non coding RNAs crucial for human

stromal cell reprogramming to vascular and cardiac precursors in response to

nitric oxide”. PI: Francesco Spallotta, PhD, Postdoctoral Fellow in Gaetano’s

lab; Co‐PI: Prof. Gaetano. Amount granted:

$ 49.500

Jan 2014‐Jan 2017 Grant from German Research Foundation (DFG). Grant number SFB834‐

B11N. Project title: “Role of the P300/CBP associated factor in endothelial

signaling”. PI: Prof. Carlo Gaetano. Amount granted:

$ 250.000

Dec 2014‐Dec 2015

Grant from the Cell and Gene Therapy Center (CGT) Frankfurt. Project title:

“Identification of zinc‐finger protein Castor 1 (Casz1) targets important

during cardiac mesenchymal stromal cell reprogramming into cardiomyocyte

precursors”. PI Francesco Spallotta PhD, Postdoctoral fellow in Gaetanoʹs lab.

Co‐PI Prof. Carlo Gaetano. Amount granted:

$ 45.000

Dec 2014‐Dec 2016

Grant from German Science Foundation & Cardio‐Pulmonary Research

Cluster of Excellence (ECCPS). Grant title: “Epimetabolic Assessment of

Human Cardiac Stromal Cells as “Sensors” of the Heart micro‐environment”.

PI Francesco Spallotta PhD, Postdoctoral Fellow in Gaetanoʹs lab. Co‐PI Prof.

Carlo Gaetano. Amount granted:

$ 165.000

Skills & Activities

Skills Molecular Biology, Cell Biology, Acetylation, Cancer Biology, Endothelial

Cells, Biomarkers, Epigenetics, Chromatin, microRNA, Cardiology, Vascular

Diseases, Transcription, Gene Expression, Chromatin Remodeling, Cell

Culture, Gene Regulation, Gene Expression and Chromatin Biology, RNA,

Regulation of Gene Expression, DNA, DNA Methylation, Cloning,

Transcriptional Regulation, Histone Modification, Molecular Cloning,

Chromatin Structure, Chromatin Biology, Methylation, Histone Proteins,

Quantitative Gene Regulation.

Languages Italian (mother tongue), English (fluent).

Scientific Memberships

& Review board panels

2006‐present : Member of the Italian Society for Life Science.

2010‐present: Member of the BCVS Council‐American Heart

2011‐present : Fellow of the American Heart Association.

2014‐present: Member of the Functional Genomics and Translational Biology

Scientific Council‐American Heart Association.

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2014‐2016: Functional Genomics and Translational Biology Scientific Council‐

American Heart Association Leadership Committee Member‐at‐large.

2014‐present: Member of the European Association for the Study of Diabetes.

2014‐ Member of the “Regenerative Medicine”panel review board, EU

projects, Horizon 2020 research program. Brussels (BE).

2014‐2015‐Project Reviewer for the “Agence Nationale de la Recherche”:

recherche translationnelle en santé. Paris (FR).

2015-Project Reviewer for the “Czech Health Research Council”, Praha (CZ)

2015‐ Chairman of the Italian Ministry of Health Review Board panel for

“Health Research Projects”, Rome (Italy).

Conference organization/ Teaching Experience (last three years)

Oct 2013: Organizer

Goethe‐Universität Frankfurt am Main ∙ Medizinische Klinik III: Kardiologie,

Angiologie/Hämostaseologie, Nephrologie, Frankfurt am Main, Germany

First ʺVilla Vigoniʺ International Conference on ʺCells, genes and molecules for cardiac and

vascular regenerationʺ, Menaggio, Italy

Sep 2014: Organizer

IBSA International Symposium on aging: ʺAging, is it a disease?ʺ, Unklinikum, Frankurt am

Main, Germany.



June 2015: Organizer

Cell and Gene Therapy Center (CGT), Frankfurt am Main, Germany. First CGT international

workshop on DNA methylation.

Oct 2015: Organizer



Second ʺVilla Vigoniʺ International Conference on ʺCells, genes and molecules for cardiac and

vascular regenerationʺ, Menaggio, Italy

Nov 2014: Teacher

Master in Molecular Medicine Lesson title: Stem cell therapy in cardiovascular diseases.

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Angiologie/Hämostaseologie, Nephrologie, ∙ Frankfurt am Main, Germany

Jul 2014: Teacher

IRTG Lecture Series:ʺGenetic principles of vascular diseasesʺ

Goethe‐Universität Frankfurt am Main, Medizinische Klinik III: Kardiologie,


Jun 2014: Presenter

Workshop on ʺMolecular basis of Epigeneticsʺ

Goethe‐Universität Frankfurt am Main, Medizinische Klinik III: Kardiologie,


Oct 2015: Organizer

Summer School of the LOEWE Centre for Cell and Gene Therapy 2015

PhD School Program, Goethe University, October 8th and 9th, 2015

Paul‐Ehrlich‐Institute (PEI), Langen, Germany

Nov 2015: Teacher

Master in Molecular Medicine. Lesson title: Molecular basis of cellular reprogramming.


Angiologie/Hämostaseologie, Nephrologie, ∙ Frankfurt am Main, Germany

Current research interest (last three years)

About main objectives and goals associated to my Professorship

Introduction

Since June 2012 I hold a non‐tenured Professorship (contract term: June 2012‐June 2017) at the Cell

and Gene Therapy Centre (CGT) of the Johannes Wolfgang Goethe University. This professorship it is

for research‐only and does not imply teaching or clinical activity. However, during this period I had

the honour to became Faculty Member of the Excellence Cluster in Cardio‐Pulmonary Research

(ECCPS) sponsored by the German Science Foundation (German equivalent of the National Institutes

of Health in USA) and I was allowed to teach monographic lessons or to present data in specialized

workshops. In addition, I co‐organized four international conferences: the first (October 2013) and

second (October 2015) “Villa Vigoni” meeting on “cardiac and vascular regeneration”; the IBSA

International Conference on Aging held at Goethe University on September 2014; and The “First

International CGT meeting on DNA methylation” has been organized in June 2015.

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Scientific Research

I have a long standing research interest in cardiovascular epigenetics. Since I am at Goethe University

(May 2012) my main research activity has been focused on human subjects and specifically on the

characterization of epigenetic mechanisms important for the homeostasis of the human vascular and

cardiac districts with special attention paid to pathophysiological conditions that may affect cellular

and organ function including dysmetabolism and diabetes. My laboratory is currently focused on the

understanding of molecular cues at the basis of epigenetic memory and metabolic alterations in

human patients undergoing major cardiac surgery. Special attention is given to the metabolomics

profile of those metabolites important for epigenetic processes including DNA methylation and

subsequent modification of methylated cytosines including formation of hydroxymethyl‐, formyl‐ and

carboxyl‐cytosine. These modifications are currently determined in cardiac biopsis, in isolated cardiac

auricles, in isolated primary cardiac fibroblasts and in peripheral blood samples. In addition, I started

the characterization of a number of new epigenetically active molecules targeting epigenetic enzymes

important for DNA methylation control including DNA methyl transferases and DNA demethylases

alias Ten‐Eleven‐Translocation proteins (TETs). Specific aim of this research activity is to understand

the potential application of novel small molecule pro‐drugs to relevant human cardiovascular diseases

and cardiovascular risk factors including metabolic syndrome and diabetes. In brief, human cardiac

fibroblasts may be considered important to evaluate the effect metabolic alterations potentially

affecting adult cardiac stem cell function. Since, I started my current appointment at Goethe

University (May 2012) a number of human primary cardiac fibroblast preparations (about 50) have

been generated in close collaboration with Prof. Andreas M. Zeiher (Director of the Dept. of

Cardiology at Goethe University Hospital) and Prof. Andres Beiras‐Fernandez of the Thoracic Surgery

Clinic of the Goethe University Hospital. These cells have been used for investigations aimed at

understanding whether an altered metabolism, possible consequence of diabetes, may subsist as a cell

autonomous defect realizing a condition able to permanently alter the intracellular environment,

preventing or reducing the proliferation and differentiation potential of these cells. This research is

still in progress, however, our manuscript published in Diabetes on January 2014, indicates the

presence of horizontally inherited epigenetic defects in human cardiac stromal cells leading to the

accumulation of abnormal DNA methylation in cell obtained from patients with clinical history of

Diabetes. These alterations are detectable ex vivo and in well controlled metabolic conditions. Our

study is now focused on the results of an integrated metabolomic, transcriptomic, genomic approach

in order to understand at which level the alteration is most evident and at what extent. Parallel to this

research, in collaboration with other Institutions in Europe and US we started to characterize new

small molecules targeted to specific epigenetic enzymes deputed at DNA methylation regulation

including DNA methyl‐trasferases (DNMTs) and Ten‐eleven‐translocation (TET) enzymes. This

research recently led to the identification of new lead compounds capable of modulate the content of

methylated DNA in cardiac stromal cells rescuing, at least partially, the intrinsic functional defect. In

addition, in collaboration with Prof. Evelyn Ullrich of the Pediatric Oncology Clinic at KGU, I started a

to evaluate the effect of epigenetically active drugs on the proliferation of human Natural Killer cells

suited for antitumor activity. This activity is currently ongoing.

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Specific Results:

Identification of the histone acetylase activator SPV106 as a potential activator of cellular

proliferation which has been now reported by us as effective on metabolically compromised

cardiac mesenchymal cell isolated from diabetic patients restoring function (1).

Evaluation of SPV106 effect of human natural killer cells proliferation and request for patent

regarding the use of SPV106 for the activation of primary human cell functions have been

approved by Goethe University. The final patent application is now submitted to the

European Patent Office (Application N. 14 179 989.0).

Characterization of new epigenetically active molecules, targeting DNA methylases and

demethylases (TET proteins). 5 compounds selected for further investigation. One of these

molecules received a first positive evaluation for the patent attorney and it is currently

preparing for a second evaluation by the Goethe University Patenting Committee in 2015 (see

attached document).

Isolation and characterization of 50 cardiac human fibroblast primary cultures obtained from

diabetic and non‐diabetic patients undergoing cardiac surgery.

Identification of altered DNA methylation content in human cardiac cells and peripheral

blood obtained from diabetic donors undergoing cardiac surgery for CABG.

Patents

1. “Use of SPV‐106 for ex‐vivo expansion of immune cells in cellular therapy” PATENT

PENDING APPLICATION AT THE EUROPEAN PATENT OFFICE (NO. 14 179 989.0)

2. “Use of ten‐eleven proteins modulators in Diabetes complications” IN PREPARATION

Top Publications

1. M Fiorilli, M Carbonari, B Scarpati, G Scano, C Gaetano, F Aiuti: Immunoglobulins in the

acquired immunodeficiency syndrome. Annals of Internal Medicine 07/1985; 102(6):862‐3.

2. M Carbonari, M Cherchi, R Paganelli, G Giannini, E Galli, C Gaetano, C Papetti, M Fiorilli:

Relative increase of T cells expressing the gamma/delta rather than the alpha/beta receptor in ataxia‐

telangiectasia. New England Journal of Medicine 02/1990; 322(2):73‐6.

3. C Gaetano, G Scano, M Carbonari, G Giannini, I Mezzaroma, F Aiuti, L Marolla, A M Casadei,

E Carapella: Delayed and defective anti‐HIV IgM response in infants. The Lancet 04/1987;

1(8533):631. DOI:10.1016/S0140‐6736(87)90272‐8

4. C Gaetano, T Matsuo, C J Thiele: Identification and characterization of a retinoic acidregulated

human homologue of the unc‐33‐like phosphoprotein (hUlip) from neuroblastoma cells. Journal of

Biological Chemistry 06/1997; 272(18):12195‐201. DOI:10.1074/jbc.272.18.12195

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5. B Illi, P Puri, L Morgante, M C Capogrossi, C Gaetano: Nuclear factor‐kappaB and cAMP

response element binding protein mediate opposite transcriptional effects on the flk‐1/KDR gene

promoter. Circulation Research 07/2000; 86(12):E110‐7. DOI:10.1161/01.RES.86.12.e110

6. D DʹArcangelo, F Facchiano, L M Barlucchi, G Melillo, B Illi, L Testolin, C Gaetano, M C

Capogrossi: Acidosis Inhibits Endothelial Cell Apoptosis and Function and Induces Basic Fibroblast

Growth Factor and Vascular Endothelial Growth Factor Expression. Circulation Research 03/2000;

86(3):312‐8. DOI:10.1161/01.RES.86.3.312

7. Carlo Gaetano, Alfonso Catalano, Barbara Illi, Angelina Felici, Saverio Minucci, Roberta

Palumbo, Francesco Facchiano, Antonella Mangoni, Salvatore Mancarella, Judith Mühlhauser,

Maurizio C. Capogrossi: Retinoids Induce Fibroblast Growth Factor‐2 Production in Endothelial

Cells via Retinoic Acid Receptor α Activation and Stimulate Angiogenesis In Vitro and In Vivo.

Circulation Research 04/2001; 88(4):E38‐47. DOI:10.1161/01.RES.88.4.e38

8. Barbara Illi, Simona Nanni, Alessandro Scopece, Antonella Farsetti, Paolo Biglioli, Maurizio C

Capogrossi, Carlo Gaetano: Shear stress‐mediated chromatin remodeling provides molecular basis

for flow‐dependent regulation of gene expression. Circulation Research 08/2003; 93(2):155‐61.

9. Germana Zaccagnini, Fabio Martelli, Pasquale Fasanaro, Alessandra Magenta, Carlo Gaetano,

Anna Di Carlo, Paolo Biglioli, Marco Giorgio, Ines Martin‐Padura, Pier Giuseppe Pelicci,

Maurizio C Capogrossi: p66(ShcA) modulates tissue response to hindlimb ischemia. Circulation

07/2004; 109(23):2917‐23. DOI:10.1161/01.CIR.0000129309.58874.0F

10. G C Minetti, C Colussi, R Adami, C Serra, C Mozzetta, V Parente, S Fortuni, S Straino, M

Sampaolesi, M Di Padova, B Illi, P Gallinari, C Steinkühler, M C Capogrossi, V Sartorelli, R

Bottinelli, C Gaetano, P L Puri: Functional and morphological recovery of dystrophic muscles in mice

treated with deacetylase inhibitors. Nature Medicine 11/2006; 12(10):1147‐50.

11. Barbara Illi, Claudio Dello Russo, Claudia Colussi, Jessica Rosati, Michele Pallaoro, Francesco

Spallotta, Dante Rotili, Sergio Valente, Gianluca Ragone, Fabio Martelli, Paolo Biglioli,

Christian Steinkuhler, Paola Gallinari, Antonello Mai, Maurizio C Capogrossi, Carlo Gaetano:

Nitric oxide modulates chromatin folding in human endothelial cells via protein phosphatase 2A

activation and class II histone deacetylases nuclear shuttling. Circulation Research 02/2008;

102(1):51‐8.

12. Claudia Colussi, Chiara Mozzetta, Aymone Gurtner, Barbara Illi, Jessica Rosati, Stefania

Straino, Gianluca Ragone, Mario Pescatori, Germana Zaccagnini, Annalisa Antonini, Giulia

Minetti, Fabio Martelli, Giulia Piaggio, Paola Gallinari, Christian Steinkuhler, Christian

Steinkulher, Emilio Clementi, Carmela DellʹAversana, Lucia Altucci, Antonello Mai, Maurizio

C Capogrossi, Pier Lorenzo Puri, Carlo Gaetano: HDAC2 blockade by nitric oxide and histone

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deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment..

Proceedings of the National Academy of Sciences 01/2009; 105(49):19183‐7.

13. Simona Nanni, Valentina Benvenuti, Annalisa Grasselli, Carmen Priolo, Aurora Aiello,

Stefania Mattiussi, Claudia Colussi, Vittoria Lirangi, Barbara Illi, Manuela DʹEletto, Anna

Maria Cianciulli, Michele Gallucci, Piero De Carli, Steno Sentinelli, Marcella Mottolese, Paolo

Carlini, Lidia Strigari, Stephen Finn, Elke Mueller, Giorgio Arcangeli, Carlo Gaetano,

Maurizio C Capogrossi, Raffaele Perrone Donnorso, Silvia Bacchetti, Ada Sacchi, Alfredo

Pontecorvi, Massimo Loda, Antonella Farsetti: Endothelial NOS, estrogen receptor β, and HIFs

cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer.

The Journal of Clinical Investigation 05/2009; 119(5):1093‐108. DOI:10.1172/JCI35079

14. Jessica Rosati, Francesco Spallotta, Simona Nanni, Annalisa Grasselli, Annalisa Antonini, Sara

Vincenti, Carlo Presutti, Claudia Colussi, Carmen DʹAngelo, Anna Biroccio, Antonella

Farsetti, Maurizio C Capogrossi, Barbara Illi, Carlo Gaetano: Smad‐interacting protein‐1 and

microRNA 200 family define a nitric oxide‐dependent molecular circuitry involved in embryonic stem

cell mesendoderm differentiation. Arteriosclerosis Thrombosis and Vascular Biology 01/2011;

31(4):898‐907.

15. Claudia Colussi, Jessica Rosati, Stefania Straino, Francesco Spallotta, Roberta Berni, Donatella

Stilli, Stefano Rossi, Ezio Musso, Emilio Macchi, Antonello Mai, Gianluca Sbardella, Sabrina

Castellano, Cristina Chimenti, Andrea Frustaci, Angela Nebbioso, Lucia Altucci, Maurizio C

Capogrossi, Carlo Gaetano: Nε‐lysine acetylation determines dissociation from GAP junctions and

lateralization of connexin 43 in normal and dystrophic heart. Proceedings of the National

Academy of Sciences 02/2011; 108(7):2795‐800.

16. Claudia Colussi, Alessandro Scopece, Serena Vitale, Francesco Spallotta, Stefania Mattiussi,

Jessica Rosati, Barbara Illi, Antonello Mai, Sabrina Castellano, Gianluca Sbardella, Antonella

Farsetti, Maurizio C Capogrossi, Carlo Gaetano: P300/CBP Associated Factor Regulates

Nitroglycerin‐Dependent Arterial Relaxation by N{varepsilon}‐Lysine Acetylation of Contractile

Proteins. Arteriosclerosis Thrombosis and Vascular Biology 08/2012; 32(10):2435‐43.

17. Francesco Spallotta, Chiara Cencioni, Stefania Straino, Simona Nanni, Jessica Rosati, Simona

Artuso, Isabella Manni, Claudia Colussi, Giulia Piaggio, Fabio Martelli, Sergio Valente,

Antonello Mai, Maurizio C Capogrossi, Antonella Farsetti, Carlo Gaetano: A Nitric Oxide‐

dependent Crosstalk Between Class I and III Histone Deacetylases Accelerates Skin Repair. Journal of

Biological Chemistry 03/2013.

18. Matteo Vecellio, Francesco Spallotta, Simona Nanni, Claudia Colussi, Chiara Cencioni, Anja

Derlet, Beatrice Bassetti, Manuela Tilenni, Maria Cristina Carena, Antonella Farsetti, Gianluca

Sbardella, Sabrina Castellano, Antonello Mai, Fabio Martelli, Giulio Pompilio, Maurizio C

Capogrossi, Alessandra Rossini, Stefanie Dimmeler, Andreas M Zeiher, Carlo Gaetano: The

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Histone Acetylase Activator Pentadecylidenemalonate 1b Rescues Proliferation and Differentiation in

Human Cardiac Mesenchymal Cells of Type 2 Diabetic Patients. Diabetes 01/2014;

Journal covers

1. Barbara Illi, Alessandro Scopece, Simona Nanni, Antonella Farsetti, Liliana Morgante,

Paolo Biglioli, Maurizio C Capogrossi, Carlo Gaetano: Epigenetic histone modification and

cardiovascular lineage programming in mouse embryonic stem cells exposed to laminar shear

stress. Circulation Research 04/2005; 96(5):501‐8. DOI:10.1161/01.RES.0000159181.06379.63

2. Annalisa Grasselli, Simona Nanni, Claudia Colussi, Aurora Aiello, Valentina Benvenuti,

Gianluca Ragone, Fabiola Moretti, Ada Sacchi, Silvia Bacchetti, Carlo Gaetano, Maurizio

C Capogrossi, Alfredo Pontecorvi, Antonella Farsetti: Estrogen Receptor‐α and Endothelial

Nitric Oxide Synthase Nuclear Complex Regulates Transcription of Human Telomerase.

Circulation Research 07/2008; 103(1):34‐42. DOI:10.1161/CIRCRESAHA.107.169037.

3. C Colussi, C Banfi, M Brioschi, E Tremoli, S Straino, F Spallotta, A Mai, D Rotili, M C

Capogrossi, C Gaetano: Proteomic profile of differentially expressed plasma proteins from

dystrophic mice and following suberoylanilide hydroxamic acid treatment. Proteomics ‐ Clinical

Applications 01/2010; 4(1):71‐83. DOI:10.1002/prca.200900116.

4. Simona Nanni, Carmen Priolo, Annalisa Grasselli, Manuela DʹEletto, Roberta Merola,

Fabiola Moretti, Michele Gallucci, Piero De Carli, Steno Sentinelli, Anna Maria Cianciulli,

Marcella Mottolese, Paolo Carlini, Diego Arcelli, Mauro Helmer‐Citterich, Carlo Gaetano,

Massimo Loda, Alfredo Pontecorvi, Silvia Bacchetti, Ada Sacchi, Antonella Farsetti:

Epithelial‐Restricted Gene Profile of Primary Cultures from Human Prostate Tumors: A

Molecular Approach to Predict Clinical Behavior of Prostate Cancer. Molecular Cancer

Research 03/2006; 4(2):79‐92. DOI:10.1158/1541‐7786.MCR‐05‐0098.

Invited Reviews/Editorials

1. Barbara Illi, Carlo Gaetano, Maurizio C Capogrossi: How senescent vascular cells lose their Clock

age‐dependent impairment of circadian rhythmicity in smooth muscle cells. Circulation Research

04/2006; 98(4):450‐2. DOI:10.1161/01.RES.0000214331.90904.aa

2. Carlo Gaetano, Claudia Colussi, Maurizio C Capogrossi: PEDF, PPAR‐gamma, p53: Deadly

circuits arise when worlds collide. Cardiovascular Research 12/2007; 76(2):195‐6.

DOI:10.1016/j.cardiores.2007.08.011

3. C Colussi, C Gaetano, MC Capogrossi: AAV‐dependent targeting of myostatin function: follistatin

strikes back at muscular dystrophy. Gene therapy 09/2008; 15(15):1075‐6. DOI:10.1038/gt.2008.95

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4. Antonella Farsetti, Annalisa Grasselli, Silvia Bacchetti, Carlo Gaetano, Maurizio C Capogrossi:

The telomerase tale in vascular aging: Regulation by estrogens and nitric oxide signaling. Journal of

Applied Physiology 12/2008; 106(1):333‐7. DOI:10.1152/japplphysiol.91360.2008

5. Barbara Illi, Claudia Colussi, Annalisa Grasselli, Antonella Farsetti, Maurizio C Capogrossi,

Carlo Gaetano: NO sparks off chromatin: Tales of a multifaceted epigenetic regulator. Pharmacology

& Therapeutics 09/2009; 123(3):344‐52. DOI:10.1016/j.pharmthera.2009.05.003

6. Claudia Colussi, Barbara Illi, Jessica Rosati, Francesco Spallotta, Antonella Farsetti, Annalisa

Grasselli, Antonello Mai, Maurizio C Capogrossi, Carlo Gaetano: Histone deacetylase inhibitors:

Keeping momentum for neuromuscular and cardiovascular diseases treatment. Pharmacological

Research 03/2010; 62(1):3‐10. DOI:10.1016/j.phrs.2010.02.014

7. Carlo Gaetano, Maurizio C. Capogrossi, Maurizio Fanciulli, Patrizia Filetici, Giulia Piaggio:

Epigenetics in Rome: Breaking news from the Chromatin Remodeling and Human Disease

Workshop. Epigenetics: official journal of the DNA Methylation Society 04/2010; 5(3).

DOI:10.4161/epi.5.3.11200

8. Barbara Illi, Claudia Colussi, Jessica Rosati, Francesco Spallotta, Simona Nanni, Antonella

Farsetti, Maurizio C Capogrossi, Carlo Gaetano: NO points to epigenetics in vascular

development. Cardiovascular Research 90: 447‐456. Cardiovascular Research 02/2011; 90(3):447‐

56. DOI:10.1093/cvr/cvr056

9. Alessandra Magenta, Simona Greco, Carlo Gaetano, Fabio Martelli: Oxidative Stress and

MicroRNAs in Vascular Diseases. International Journal of Molecular Sciences 09/2013;

14(9):17319‐46. DOI:10.3390/ijms140917319

10. Chiara Cencioni, Francesco Spallotta, Fabio Martelli, Sergio Valente, Antonello Mai, Andreas

M Zeiher, Carlo Gaetano: Oxidative Stress and Epigenetic Regulation in Ageing and Age‐Related

Diseases. International Journal of Molecular Sciences 09/2013; 14(9):17643‐63.

DOI:10.3390/ijms140917643

11. Simona Greco, Carlo Gaetano, Fabio Martelli: HypoxamiR Regulation and Function in Ischemic

Cardiovascular Diseases. Antioxidants & Redox Signaling 09/2013; 21(8).

DOI:10.1089/ars.2013.5403

12. Alessandra Magenta, Simona Greco, Maurizio C Capogrossi, Carlo Gaetano, Fabio Martelli:

Nitric Oxide, Oxidative Stress, and p66 Shc Interplay in Diabetic Endothelial Dysfunction. Biomed

Res Int. 2014:193095. doi: 10.1155/2014/193095

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13. Chiara Cencioni, Francesco Spallotta, Simona Greco, Fabio Martelli, Andreas M Zeiher, Carlo

Gaetano: Epigenetic mechanisms of hyperglycemic memory. The International Journal of

Biochemistry & Cell Biology 04/2014; 51(1). DOI:10.1016/j.biocel.2014.04.014

14. Chiara Cencioni, Francesco Spallotta, Antonello Mai, Fabio Martelli, Antonella Farsetti,

Andreas M Zeiher, Carlo Gaetano: Sirtuin function in aging heart and vessels. Journal of

Molecular and Cellular Cardiology 01/2015; 83. DOI:10.1016/j.yjmcc.2014.12.023

Peer Reviewed Journal Publications (full list)

1. M Fiorilli, M Carbonari, B Scarpati, G Scano, C Gaetano, F Aiuti: Immunoglobulins in the

acquired immunodeficiency syndrome. Annals of Internal Medicine 07/1985; 102(6):862‐3.

2. Massimo Fiorilli, Marco Crescenzi, Maurizio Carbonari, Letizia Tedesco, Giandomenico

Russo, Carlo Gaetano, Fernando Aiuti: Phenotypically immature IgG‐bearing B cells in patients

with hypogammaglobulinemia. Journal of Clinical Immunology 12/1985; 6(1):21‐25.

DOI:10.1007/BF00915360

3. P Rossi, M Carbonari, R Bonomo, M Galli, P E Manconi, B Scarpati, G Scano, C Gaetano, B

Ensoli, F Aiuti: Epidemiological aspects of HTLV‐III infection in Italy. European Journal of

Epidemiology 01/1986; 1(4):288‐93. DOI:10.1007/BF00237104

4. C Gaetano, G Scano, M Carbonari, G Giannini, I Mezzaroma, F Aiuti, L Marolla, A M Casadei,

E Carapella: Delayed and defective anti‐HIV IgM response in infants. The Lancet 04/1987;

1(8533):631. DOI:10.1016/S0140‐6736(87)90272‐8

5. M Crescenzi, M Napolitano, M Carbonari, A Antonelli, P Petrinelli, C Gaetano, M Fiorilli:

Establishment of a new Epstein‐Barr virus‐immortalized cell line from chronic lymphocytic leukemia

with trisomy of chromosome 12 that produces monoclonal IgM against a sheep RBC antigen. Blood

02/1988; 71(1):9‐12.

6. Maurizio Carbonari, Michela Cherchi, Roberto Paganelli, Giuseppe Giannini, Elena Galli,

Carlo Gaetano, Claudia Papetti, Massimo Fiorilli: Relative Increase of T Cells Expressing the

Gamma/Delta Rather Than the Alpha/Beta Receptor in Ataxia‐Telangiectasia. New England Journal

of Medicine 02/1990; 322(2):73‐6. DOI:10.1056/NEJM199001113220201

7. A Farsetti, A Pontecorvi, I Antonozzi, M Andreoli, C Gaetano: Cytofluorometric analysis of

lymphocyte subsets in thyroid aspirates from patients with autonomously functioning nodule. Clinical

Endocrinology 06/1990; 32(6):729‐38.

8. C Gaetano, K Matsumoto, C J Thiele: Retinoic acid resistant neuroblastoma cells and the expression

of insulin‐like growth factor‐II. Progress in clinical and biological research 02/1991; 366:165‐72.

13

9. C Gaetano, K Matsumoto, C J Thiele: Retinoic acid negatively regulates p34cdc2 expression during

human neuroblastoma differentiation. Cell growth & differentiation: the molecular biology

journal of the American Association for Cancer Research 11/1991; 2(10):487‐93.

10. K Matsumoto, C Gaetano, W H Daughaday, CJ Thiele: Retinoic acid regulates insulin‐like growth

factor II expression in neuroblastoma cell line. Endocrinology 07/1992; 130(6):3669‐76.

DOI:10.1210/en.130.6.3669

11. C Gaetano, K Matsumoto, C J Thiele: In vitro activation of distinct molecular and cellular

phenotypes after induction of differentiation in a human neuroblastoma cell line. Cancer Research

09/1992; 52(16):4402‐7.

12. CJ Thiele, C Gaetano, K Matsumoto: Coordinate regulation of oncogenes, suppressor genes and cell

cycle genes in human neuroblastoma cell lines sensitive to retinoic acid and its disruption in NB cells

constitutively expressing IGF‐II. Biomedicine & Pharmacotherapy 12/1992; 46(5‐7).

DOI:10.1016/0753‐3322(92)90187‐C

13. Carlo Gaetano, Antonella Melchiori, Adriana Albini, Robetto Benelli, Rita Falcioni, Andrea

Modesti, A. Modica, Susanna Scarpa, Ada Sacchi: Retinoic acid negatively regulates β4 integrin

expression and suppresses the malignant phenotype in a Lewis lung carcinoma cell line. Clinical and

Experimental Metastasis 01/1994; 12(1):63‐72. DOI:10.1007/BF01784335

14. K Matsumoto, E Lucarelli, C Minniti, C Gaetano, CJ Thiele: Signals transduced via insulin‐like

growth factor I receptor (IGF(R)) mediate resistance to retinoic acid‐induced cell growth arrest in a

human neuroblastoma cell line. Cell Death and Differentiation 08/1994; 1(1):49‐58.

15. Pamela Cohen, JJ Letterio, C Gaetano, J Chan, K Matsumoto, MB Sporn, CJ Thiele: Induction of

transforming growth factor beta 1 and its receptors during all‐trans‐retinoic acid (RA) treatment of

RA‐responsive human neuroblastoma cell lines. Cancer Research 1995 Jun 1;55(11):2380‐6. PMID:

7757990.

16. C Gaetano, I Manni, G Bossi, G Piaggio, S Soddu, A Farina, L J Helman, A Sacchi: Retinoic acid

and cAMP differentially regulate human chromogranin A promoter activity during differentiation of

neuroblastoma cells. European Journal of Cancer 02/1995; 31A(4):447‐52. DOI:10.1016/0959‐

8049(95)00038‐K

17. G Piaggio, A Farina, D Perrotti, I Manni, P Fuschi, A Sacchi, C Gaetano: Structure and Growth‐

Dependent Regulation of the Human Cyclin B1 Promoter. Experimental Cell Research 03/1995;

216(2):396‐402. DOI:10.1006/excr.1995.1050

18. A Farina, C Gaetano, M Crescenzi, F Puccini, I Manni, A Sacchi, G Piaggio: The inhibition of

cyclin B1 gene transcription in quiescent NIH3T3 cells is mediated by an E‐box. Oncogene 10/1996;

13(6):1287‐96.

14

19. C Gaetano, Y Kitajima, K. Matsumoto, T Matsuo, CJ Thiele: Identification of a Novel Thyroid

Hormone Receptor Responsive Element in the Human trk‐B Promoter. European Journal of Cancer

01/1997; 33(12). DOI:10.1016/S0959‐8049(97)00415‐2

20. C Gaetano, T Matsuo, C J Thiele: Identification and characterization of a retinoic acidregulated

human homologue of the unc‐33‐like phosphoprotein (hUlip) from neuroblastoma cells. Journal of

Biological Chemistry 06/1997; 272(18):12195‐201. DOI:10.1074/jbc.272.18.12195

21. D DʹArcangelo, F Facchiano, L M Barlucchi, G Melillo, B Illi, L Testolin, C Gaetano, M C

Capogrossi: Acidosis Inhibits Endothelial Cell Apoptosis and Function and Induces Basic Fibroblast

Growth Factor and Vascular Endothelial Growth Factor Expression. Circulation Research 03/2000;

86(3):312‐8. DOI:10.1161/01.RES.86.3.312

22. C Giampietri, M Levrero, A Felici, A DʹAlessio, M C Capogrossi, C Gaetano: E1A stimulates

FGF‐2 release promoting differentiation of primary endothelial cells. Cell Death and Differentiation

04/2000; 7(3):292‐301. DOI:10.1038/sj.cdd.4400654

23. B Illi, P Puri, L Morgante, M C Capogrossi, C Gaetano: Nuclear factor‐kappaB and cAMP

response element binding protein mediate opposite transcriptional effects on the flk‐1/KDR gene

promoter. Circulation Research 07/2000; 86(12):E110‐7. DOI:10.1161/01.RES.86.12.e110

24. Diana Bellavia, Antonio F. Campese, Edoardo Alesse, Alessandra Vacca, Maria Pia Felli, Anna

Balestri, Antonella Stoppacciaro, Cecilia Tiveron, Laura Tatangelo, Mirella Giovarelli, Carlo

Gaetano, Luigi Ruco, Eric S. Hoffman, Adrian C. Hayday, Urban Lendahl, Luigi Frati, Alberto

Gulino, Isabella Screpanti: Constitutive activation of NF‐B and T‐cell leukemia/lymphoma in Notch3

transgenic mice. The EMBO Journal 07/2000; 19(13):3337‐3348. DOI:10.1093/emboj/19.13.3337

25. R Palumbo, C Gaetano, G Melillo, E Toschi, A Remuzzi, M C Capogrossi: Shear Stress

Downregulation of Platelet‐Derived Growth Factor Receptor‐ and Matrix Metalloprotease‐2 Is

Associated With Inhibition of Smooth Muscle Cell Invasion and Migration. Circulation 08/2000;

102(2):225‐30. DOI:10.1161/01.CIR.102.2.225

26. C Gaetano, A Catalano, R Palumbo, B Illi, G Orlando, G Ventoruzzo, F Serino, M C

Capogrossi: Transcriptionally active drugs improve adenovirus vector performance in vitro and in

vivo. Gene Therapy 11/2000; 7(19):1624‐30. DOI:10.1038/sj.gt.3301296

27. Carlo Gaetano, Alfonso Catalano, Barbara Illi, Angelina Felici, Saverio Minucci, Roberta

Palumbo, Francesco Facchiano, Antonella Mangoni, Salvatore Mancarella, Judith Mühlhauser,

Maurizio C. Capogrossi: Retinoids Induce Fibroblast Growth Factor‐2 Production in Endothelial

Cells via Retinoic Acid Receptor α Activation and Stimulate Angiogenesis In Vitro and In Vivo.

Circulation Research 04/2001; 88(4):E38‐47. DOI:10.1161/01.RES.88.4.e38

15

28. Roberta Palumbo, Carlo Gaetano, Annalisa Antonini, Giulio Pompilio, Enrico Bracco, Lars

Rönnstrand, Carl‐Henrik Heldin, Maurizio C Capogrossi: Different effects of high and low shear

stress on platelet‐derived growth factor isoform release by endothelial cells ‐ Consequences for smooth

muscle cell migration. Arteriosclerosis Thrombosis and Vascular Biology 03/2002; 22(3):405‐11.

DOI:10.1161/hq0302.104528

29. Paolo Turrini, Carlo Gaetano, Alessia Antonelli, Maurizio C Capogrossi, Luigi Aloe: Nerve

growth factor induces angiogenic activity in a mouse model of hindlimb ischemia. Neuroscience

Letters 04/2002; 323(2):109‐12. DOI:10.1016/S0304‐3940(02)00090‐3

30. Irene Massari, Alessia Donnini, Katy Argentati, Stefania Straino, Antonella Mangoni, Carlo

Gaetano, Claudio Viticchi, Maurizio C. Capogrossi, Mauro Provinciali: Age‐dependent effects of

repeated immunization with a first generation adenovirus vector on the immune response and

transgene expression in young and old rats. Experimental Gerontology 06/2002; 37(6):823‐31.

DOI:10.1016/S0531‐5565(02)00011‐6

31. Daniela DʹArcangelo, Carlo Gaetano, Maurizio C Capogrossi: Acidification prevents endothelial

cell apoptosis by Axl activation. Circulation Research 10/2002; 91(7):e4‐12.

DOI:10.1161/01.RES.0000036753.50601.E9

32. Raffaella Cincinelli, Sabrina Dallavalle, Lucio Merlini, Sergio Penco, Claudio Pisano, Paolo

Carminati, Giuseppe Giannini, Loredana Vesci, Carlo Gaetano, Barbara Illi, Valentina Zuco,

Rosanna Supino, Franco Zunino: A Novel Atypical Retinoid Endowed with Proapoptotic and

Antitumor Activity. Journal of Medicinal Chemistry 04/2003; 46(6):909‐12.

DOI:10.1021/jm025593y

33. Barbara Illi, Simona Nanni, Alessandro Scopece, Antonella Farsetti, Paolo Biglioli, Maurizio C

Capogrossi, Carlo Gaetano: Shear stress‐mediated chromatin remodeling provides molecular basis

for flow‐dependent regulation of gene expression. Circulation Research 08/2003; 93(2):155‐61.

DOI:10.1161/01.RES.0000080933.82105.29

34. Corrado Cirielli, Francesco Serino, Stefania Straino, Gabriele Toietta, Damiano Abeni, Giorgio

Ventoruzzo, Giuseppe Orlando, Paola Mazzanti, Guido Melillo, Thomas J Whickham, Imre

Kovesdi, Paolo Biglioli, Carlo Gaetano, Maurizio C Capogrossi: Adenovirus vectors targeting αV

integrin or heparan sulfate receptors display different distribution of transgene activity after

intramuscular injection. The Journal of Gene Medicine 03/2004; 6(3):309‐16.

DOI:10.1002/jgm.521

35. Stefania Mattiussi, Paolo Turrini, Lucia Testolin, Fabio Martelli, Germana Zaccagnini,

Antonella Mangoni, Laura M Barlucchi, Annalisa Antonini, Barbara Illi, Corrado Cirielli, Julio

Padron, Chiara Nicolò, Roberto Testi, Francesco Osculati, Paolo Biglioli, Maurizio C

Capogrossi, Carlo Gaetano: p21(Waf1/Cip1/Sdi1) mediates shear stress‐dependent antiapoptotic

function. Cardiovascular Research 04/2004; 61(4):693‐704. DOI:10.1016/j.cardiores.2003.12.008

16

36. Barbara Illi, Alessandro Scopece, Simona Nanni, Antonella Farsetti, Maurizio C. Capogrossi,

Carlo Gaetano: Shear stress modulates chromatin structure and acts as a vascular phenotype

determinant in mouse embryonic stem cells. Cardiovascular Pathology 05/2004; 13(3):190‐191.

DOI:10.1016/j.carpath.2004.03.573

37. Daniela DʹArcangelo, Valeria Ambrosino, Gianluca Ragone, Maria Giannuzzo, Maurizio C

Capogrossi, Carlo Gaetano: Axl activation mediates laminar shear stress antiapoptotic effects in

human endothelial cells. Cardiovascular Pathology 05/2004; 13(3):194‐194.

DOI:10.1016/j.carpath.2004.03.585

38. Stefania Mattiussi, Fabio Martelli, Maurizio C. Capogrossi, Carlo Gaetano: Impairment of

paxillin function inhibits laminar shear stress sensing in human endothelial cells. Cardiovascular

Pathology 05/2004; 13(3):191‐191. DOI:10.1016/j.carpath.2004.03.575

39. Carlo Gaetano, Germana Zaccagnini, Linda Della Pietra, Simona Nanni, Maurizio C.

Capogrossi, Antonella Farsetti: Activation of telomerase through vegf signaling triggers

angiogenesis in response to hind‐limb ischemia. Cardiovascular Pathology 05/2004; 13(3):179‐180.

DOI:10.1016/j.carpath.2004.03.541

40. Germana Zaccagnini, Fabio Martelli, Pasquale Fasanaro, Alessandra Magenta, Carlo Gaetano,

Anna Di Carlo, Paolo Biglioli, Marco Giorgio, Ines Martin‐Padura, Pier Giuseppe Pelicci,

Maurizio C Capogrossi: p66(ShcA) modulates tissue response to hindlimb ischemia. Circulation

07/2004; 109(23):2917‐23. DOI:10.1161/01.CIR.0000129309.58874.0F

41. Barbara Illi, Alessandro Scopece, Simona Nanni, Antonella Farsetti, Liliana Morgante, Paolo

Biglioli, Maurizio C Capogrossi, Carlo Gaetano: Epigenetic histone modification and

cardiovascular lineage programming in mouse embryonic stem cells exposed to laminar shear stress.

Circulation Research 04/2005; 96(5):501‐8. DOI:10.1161/01.RES.0000159181.06379.63

42. Germana Zaccagnini, Carlo Gaetano, Linda Della Pietra, Simona Nanni, Annalisa Grasselli,

Antonella Mangoni, Roberta Benvenuto, Manuela Fabrizi, Silvia Truffa, Antonia Germani,

Fabiola Moretti, Alfredo Pontecorvi, Ada Sacchi, Silvia Bacchetti, Maurizio C Capogrossi,

Antonella Farsetti: Telomerase Mediates Vascular Endothelial Growth Factor‐dependent

Responsiveness in a Rat Model of Hind Limb Ischemia. Journal of Biological Chemistry 05/2005;

280(15):14790‐8. DOI:10.1074/jbc.M414644200

43. Yoon‐La Choi, Chong Jai Kim, Tatsuya Matsuo, Carlo Gaetano, Rita Falconi, Yeon‐Lim Suh,

Seok‐Hyung Kim, Young Kee Shin, Seong Hoe Park, Je Geun Chi, Carol J Thiele: HUlip, a

human homologue of unc‐33‐like phosphoprotein of Caenorhabditis elegans; Immunohistochemical

localization in the developing human brain and patterns of expression in nervous system tumors.

Journal of Neuro‐Oncology 06/2005; 73(1):19‐27. DOI:10.1007/s11060‐004‐3013‐3

44. Simona Nanni, Carmen Priolo, Annalisa Grasselli, Manuela DʹEletto, Roberta Merola, Fabiola

Moretti, Michele Gallucci, Piero De Carli, Steno Sentinelli, Anna Maria Cianciulli, Marcella

17

Mottolese, Paolo Carlini, Diego Arcelli, Mauro Helmer‐Citterich, Carlo Gaetano, Massimo

Loda, Alfredo Pontecorvi, Silvia Bacchetti, Ada Sacchi, Antonella Farsetti: Epithelial‐Restricted

Gene Profile of Primary Cultures from Human Prostate Tumors: A Molecular Approach to Predict

Clinical Behavior of Prostate Cancer. Molecular Cancer Research 03/2006; 4(2):79‐92.

DOI:10.1158/1541‐7786.MCR‐05‐0098

45. Barbara Illi, Carlo Gaetano, Maurizio C Capogrossi: How senescent vascular cells lose their Clock

age‐dependent impairment of circadian rhythmicity in smooth muscle cells. Circulation Research

04/2006; 98(4):450‐2. DOI:10.1161/01.RES.0000214331.90904.aa

46. Stefania Mattiussi, Kazue Matsumoto, Barbara Illi, Fabio Martelli, Maurizio C Capogrossi,

Carlo Gaetano: Papilloma protein E6 abrogates shear stress‐dependent survival in human endothelial

cells: Evidence for specialized functions of paxillin. Cardiovascular Research 07/2006; 70(3):578‐88.

DOI:10.1016/j.cardiores.2006.02.008

47. Daniela DʹArcangelo, Valeria Ambrosino, Maria Giannuzzo, Carlo Gaetano, Maurizio C

Capogrossi: Axl receptor activation mediates laminar shear stress anti‐apoptotic effects in human

endothelial cells. Cardiovascular Research 10/2006; 71(4):754‐63.

DOI:10.1016/j.cardiores.2006.06.002

48. G C Minetti, C Colussi, R Adami, C Serra, C Mozzetta, V Parente, S Fortuni, S Straino, M

Sampaolesi, M Di Padova, B Illi, P Gallinari, C Steinkühler, M C Capogrossi, V Sartorelli, R

Bottinelli, C Gaetano, P L Puri: Functional and morphological recovery of dystrophic muscles in mice

treated with deacetylase inhibitors. Nature Medicine 11/2006; 12(10):1147‐50.

DOI:10.1038/nm1479

49. Carlo Gaetano, Claudia Colussi, Maurizio C Capogrossi: PEDF, PPAR‐gamma, p53: Deadly

circuits arise when worlds collide. Cardiovascular Research 12/2007; 76(2):195‐6.

DOI:10.1016/j.cardiores.2007.08.011

50. Barbara Illi, Claudio Dello Russo, Claudia Colussi, Jessica Rosati, Michele Pallaoro, Francesco

Spallotta, Dante Rotili, Sergio Valente, Gianluca Ragone, Fabio Martelli, Paolo Biglioli,

Christian Steinkuhler, Paola Gallinari, Antonello Mai, Maurizio C Capogrossi, Carlo Gaetano:

Nitric Oxide Modulates Chromatin Folding in Human Endothelial Cells via Protein Phosphatase 2A

Activation and Class II Histone Deacetylases Nuclear Shuttling. Circulation Research 02/2008;

102(1):51‐8. DOI:10.1161/CIRCRESAHA.107.157305

51. Aymone Gurtner, Paola Fuschi, Fiorenza Magi, Claudia Colussi, Carlo Gaetano, Matthias

Dobbelstein, Ada Sacchi, Giulia Piaggio: NF‐Y Dependent Epigenetic Modifications Discriminate

between Proliferating and Postmitotic Tissue. PLoS ONE 02/2008; 3(4):e2047.

DOI:10.1371/journal.pone.0002047

52. Elisa Sala, Luca Mologni, Silvia Truffa, Carlo Gaetano, Gideon E Bollag, Carlo Gambacorti‐

Passerini: BRAF Silencing by Short Hairpin RNA or Chemical Blockade by PLX4032 Leads to

18

Different Responses in Melanoma and Thyroid Carcinoma Cells. Molecular Cancer Research

06/2008; 6(5):751‐9. DOI:10.1158/1541‐7786.MCR‐07‐2001

53. Annalisa Grasselli, Simona Nanni, Claudia Colussi, Aurora Aiello, Valentina Benvenuti,

Gianluca Ragone, Fabiola Moretti, Ada Sacchi, Silvia Bacchetti, Carlo Gaetano, Maurizio C

Capogrossi, Alfredo Pontecorvi, Antonella Farsetti: Estrogen Receptor‐α and Endothelial Nitric

Oxide Synthase Nuclear Complex Regulates Transcription of Human Telomerase. Circulation

Research 07/2008; 103(1):34‐42. DOI:10.1161/CIRCRESAHA.107.169037

54. C Colussi, C Gaetano, MC Capogrossi: AAV‐dependent targeting of myostatin function: follistatin

strikes back at muscular dystrophy. Gene therapy 09/2008; 15(15):1075‐6. DOI:10.1038/gt.2008.95

55. Antonella Farsetti, Annalisa Grasselli, Silvia Bacchetti, Carlo Gaetano, Maurizio C Capogrossi:

The telomerase tale in vascular aging: Regulation by estrogens and nitric oxide signaling. Journal of

Applied Physiology 12/2008; 106(1):333‐7. DOI:10.1152/japplphysiol.91360.2008

56. Claudia Colussi, Chiara Mozzetta, Aymone Gurtner, Barbara Illi, Jessica Rosati, Stefania

Straino, Gianluca Ragone, Mario Pescatori, Germana Zaccagnini, Annalisa Antonini, Giulia

Minetti, Fabio Martelli, Giulia Piaggio, Paola Gallinari, Christian Steinkuhler, Christian

Steinkulher, Emilio Clementi, Carmela DellʹAversana, Lucia Altucci, Antonello Mai, Maurizio

C Capogrossi, Pier Lorenzo Puri, Carlo Gaetano: HDAC2 blockade by nitric oxide and histone

deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment.

Proceedings of the National Academy of Sciences 01/2009; 105(49):19183‐7.

DOI:10.1073/pnas.0805514105

57. Stefania Mattiussi, Chiara Lazzari, Silvia Truffa, Annalisa Antonini, Silvia Soddu, Maurizio C

Capogrossi, Carlo Gaetano: Homeodomain Interacting Protein Kinase 2 Activation Compromises

Endothelial Cell Response to Laminar Flow: Protective Role of p21. PLoS ONE 02/2009; 4(8):e6603.

DOI:10.1371/journal.pone.0006603

58. Simona Nanni, Valentina Benvenuti, Annalisa Grasselli, Carmen Priolo, Aurora Aiello,

Stefania Mattiussi, Claudia Colussi, Vittoria Lirangi, Barbara Illi, Manuela DʹEletto, Anna

Maria Cianciulli, Michele Gallucci, Piero De Carli, Steno Sentinelli, Marcella Mottolese, Paolo

Carlini, Lidia Strigari, Stephen Finn, Elke Mueller, Giorgio Arcangeli, Carlo Gaetano,

Maurizio C Capogrossi, Raffaele Perrone Donnorso, Silvia Bacchetti, Ada Sacchi, Alfredo

Pontecorvi, Massimo Loda, Antonella Farsetti: Endothelial NOS, estrogen receptor β, and HIFs

cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer.

The Journal of Clinical Investigation 05/2009; 119(5):1093‐108. DOI:10.1172/JCI35079

59. Claudia Colussi, Aymone Gurtner, Jessica Rosati, Barbara Illi, Gianluca Ragone, Giulia

Piaggio, Maurizio Moggio, Costanza Lamperti, Grazia DʹAngelo, Emilio Clementi, Giulia

Minetti, Chiara Mozzetta, Annalisa Antonini, Maurizio C Capogrossi, Pier Lorenzo Puri,

Carlo Gaetano: Nitric oxide deficiency determines global chromatin changes in Duchenne muscular

dystrophy. The FASEB Journal 05/2009; 23(7):2131‐41. DOI:10.1096/fj.08‐115618

19

60. Barbara Illi, Claudia Colussi, Annalisa Grasselli, Antonella Farsetti, Maurizio C Capogrossi,

Carlo Gaetano: NO sparks off chromatin: Tales of a multifaceted epigenetic regulator. Pharmacology

Therapeutics 09/2009; 123(3):344‐52. DOI:10.1016/j.pharmthera.2009.05.003

61. Simona Greco, Marco De Simone, Claudia Colussi, Germana Zaccagnini, Pasquale Fasanaro,

Mario Pescatori, Rosanna Cardani, Riccardo Perbellini, Eleonora Isaia, Patrizio Sale, Giovanni

Meola, Maurizio C Capogrossi, Carlo Gaetano, Fabio Martelli: Common micro‐RNA signature in

skeletal muscle damage and regeneration induced by Duchenne muscular dystrophy and acute

ischemia. The FASEB Journal 07/2009; 23(10):3335‐46. DOI:10.1096/fj.08‐128579

62. Roberta Melchionna, Marta Romani, Valeria Ambrosino, Daniela DʹArcangelo, Chiara

Cencioni, Daniele Porcelli, Gabriele Toietta, Silvia Truffa, Carlo Gaetano, Antonella Mangoni,

Ombretta Pozzoli, Claudia Cappuzzello, Maurizio C Capogrossi, Monica Napolitano: Role of

HIF‐1alpha in proton‐mediated CXCR4 down‐regulation in endothelial cells. Cardiovascular

Research 12/2009; 86(2):293‐301. DOI:10.1093/cvr/cvp393

63. C Colussi, C Banfi, M Brioschi, E Tremoli, S Straino, F Spallotta, A Mai, D Rotili, M C

Capogrossi, C Gaetano: Proteomic profile of differentially expressed plasma proteins from dystrophic

mice and following suberoylanilide hydroxamic acid treatment. Proteomics ‐ Clinical Applications

01/2010; 4(1):71‐83. DOI:10.1002/prca.200900116

64. Claudia Colussi, Roberta Berni, Jessica Rosati, Stefania Straino, Serena Vitale, Francesco

Spallotta, Silvana Baruffi, Leonardo Bocchi, Francesca Delucchi, Stefano Rossi, Monia Savi,

Dante Rotili, Federico Quaini, Emilio Macchi, Donatella Stilli, Ezio Musso, Antonello Mai,

Carlo Gaetano, Maurizio C Capogrossi: The histone deacetylase inhibitor suberoylanilide

hydroxamic acid reduces cardiac arrhythmias in dystrophic mice. Cardiovascular Research 02/2010;

87(1):73‐82. DOI:10.1093/cvr/cvq035

65. Claudia Colussi, Barbara Illi, Jessica Rosati, Francesco Spallotta, Antonella Farsetti, Annalisa

Grasselli, Antonello Mai, Maurizio C Capogrossi, Carlo Gaetano: Histone deacetylase inhibitors:

Keeping momentum for neuromuscular and cardiovascular diseases treatment. Pharmacological

Research 03/2010; 62(1):3‐10. DOI:10.1016/j.phrs.2010.02.014

66. Francesco Spallotta, Jessica Rosati, Stefania Straino, Simona Nanni, Annalisa Grasselli, Valeria

Ambrosino, Dante Rotili, Sergio Valente, Antonella Farsetti, Antonello Mai, Maurizio C

Capogrossi, Carlo Gaetano, Barbara Illi: Nitric Oxide Determines Mesodermic Differentiation of

Mouse Embryonic Stem Cells by Activating Class IIa Histone Deacetylases: Potential Therapeutic

Implications in a Mouse Model of Hindlimb Ischemia. Stem Cells 03/2010; 28(3):431‐42.

DOI:10.1002/stem.300

67. Carlo Gaetano, Maurizio C. Capogrossi, Maurizio Fanciulli, Patrizia Filetici, Giulia Piaggio:

Epigenetics in Rome: Breaking news from the Chromatin Remodeling and Human Disease

20

Workshop. Epigenetics: official journal of the DNA Methylation Society 04/2010; 5(3).

DOI:10.4161/epi.5.3.11200

68. Barbara Illi, Claudia Colussi, Jessica Rosati, Francesco Spallotta, Simona Nanni, Antonella

Farsetti, Maurizio C Capogrossi, Carlo Gaetano: NO points to epigenetics in vascular

development. Cardiovascular Research 90: 447‐456. Cardiovascular Research 02/2011; 90(3):447‐

56. DOI:10.1093/cvr/cvr056

69. Claudia Colussi, Jessica Rosati, Stefania Straino, Francesco Spallotta, Roberta Berni, Donatella

Stilli, Stefano Rossi, Ezio Musso, Emilio Macchi, Antonello Mai, Gianluca Sbardella, Sabrina

Castellano, Cristina Chimenti, Andrea Frustaci, Angela Nebbioso, Lucia Altucci, Maurizio C

Capogrossi, Carlo Gaetano: Nε‐lysine acetylation determines dissociation from GAP junctions and

lateralization of connexin 43 in normal and dystrophic heart. Proceedings of the National

Academy of Sciences 02/2011; 108(7):2795‐800. DOI:10.1073/pnas.1013124108

70. Alessandra Rossini, Caterina Frati, Costanza Lagrasta, Gallia Graiani, Alessandro Scopece,

Stefano Cavalli, Ezio Musso, Marco Baccarin, Marina Di Segni, Francesco Fagnoni, Antonia

Germani, Eugenio Quaini, Manuel Mayr, Qingbo Xu, Andrea Barbuti, Dario DiFrancesco,

Giulio Pompilio, Federico Quaini, Carlo Gaetano, Maurizio C Capogrossi: Human cardiac and

bone marrow stromal cells exhibit distinctive properties related to their origin. Cardiovascular

Research 02/2011; 89(3):650‐60. DOI:10.1093/cvr/cvq290

71. Simona Nanni, Annalisa Grasselli, Valentina Benvenuti, Aurora Aiello, Valentina Pantisano,

Agnese Re, Carlo Gaetano, Maurizio C. Capogrossi, Silvia Bacchetti, Alfredo Pontecorvi,

Antonella Farsetti: The role of nuclear endothelial nitric oxide synthase in the endothelial and prostate

microenvironments. Hormone molecular biology and clinical investigation 03/2011; 5(2).

DOI:10.1515/HMBCI.2011.011

72. Jessica Rosati, Francesco Spallotta, Simona Nanni, Annalisa Grasselli, Annalisa Antonini, Sara

Vincenti, Carlo Presutti, Claudia Colussi, Carmen DʹAngelo, Anna Biroccio, Antonella

Farsetti, Maurizio C Capogrossi, Barbara Illi, Carlo Gaetano: Smad‐Interacting Protein‐1 and

MicroRNA 200 Family Define a Nitric Oxide‐Dependent Molecular Circuitry Involved in Embryonic

Stem Cell Mesendoderm Differentiation. Arteriosclerosis Thrombosis and Vascular Biology

03/2011; 31(4):898‐907. DOI:10.1161/ATVBAHA.110.214478

73. Ilaria Burba, Gualtiero I Colombo, Lidia Irene Staszewsky, Marco De Simone, Paolo Devanna,

Simona Nanni, Daniele Avitabile, Fabiola Molla, Simona Cosentino, Ilaria Russo, Noeleen De

Angelis, Annarita Soldo, Antonella Biondi, Elisa Gambini, Carlo Gaetano, Antonella Farsetti,

Giulio Pompilio, Roberto Latini, Maurizio C Capogrossi, Maurizio Pesce: Histone Deacetylase

Inhibition Enhances Self Renewal and Cardioprotection by Human Cord Blood‐Derived CD34+ Cells.

PLoS ONE 07/2011; 6(7):e22158. DOI:10.1371/journal.pone.0022158

74. Chiara Cencioni, Roberta Melchionna, Stefania Straino, Marta Romani, Claudia Cappuzzello,

Valentina Annese, Joseph C Wu, Giulio Pompilio, Angela Santoni, Carlo Gaetano, Monica

21

Napolitano, Maurizio C Capogrossi: Ex vivo acidic preconditioning enhances bone marrow ckit+ cell

therapeutic potential via increased CXCR4 expression. European Heart Journal 07/2011; 34(26).

DOI:10.1093/eurheartj/ehr219

75. Alessandra Giuliani, Caterina Frati, Alessandra Rossini, Vladimir S Komlev, Costanza

Lagrasta, Monia Savi, Stefano Cavalli, Carlo Gaetano, Federico Quaini, Adrian Manescu,

Franco Rustichelli: High‐resolution X‐ray microtomography for three‐dimensional imaging of cardiac

progenitor cell homing in infarcted rat hearts. Journal of Tissue Engineering and Regenerative

Medicine 08/2011; 5(8):e168‐78. DOI:10.1002/term.409

76. Viviana Meraviglia, Matteo Vecellio, Annalisa Grasselli, Marco Baccarin, Antonella Farsetti,

Maurizio C Capogrossi, Giulio Pompilio, Domenico A Coviello, Carlo Gaetano, Marina Di

Segni, Alessandra Rossini: Human chorionic villus mesenchymal stromal cells reveal strong

endothelial conversion properties. Differentiation 03/2012; 83(5):260‐70.

DOI:10.1016/j.diff.2012.02.006

77. Claudia Colussi, Alessandro Scopece, Serena Vitale, Francesco Spallotta, Stefania Mattiussi,

Jessica Rosati, Barbara Illi, Antonello Mai, Sabrina Castellano, Gianluca Sbardella, Antonella

Farsetti, Maurizio C Capogrossi, Carlo Gaetano: P300/CBP Associated Factor Regulates

Nitroglycerin‐Dependent Arterial Relaxation by N‐epsilon‐Lysine Acetylation of Contractile Proteins.

Arteriosclerosis Thrombosis and Vascular Biology 08/2012; 32(10):2435‐43.

DOI:10.1161/ATVBAHA.112.254011

78. Lucia Cicchillitti, Valeria Di Stefano, Eleonora Isaia, Luca Crimaldi, Pasquale Fasanaro,

Valeria Ambrosino, Annalisa Antonini, Maurizio C Capogrossi, Carlo Gaetano, Giulia

Piaggio, Fabio Martelli: Hypoxia‐inducible Factor 1‐α Induces miR‐210 in Normoxic Differentiating

Myoblasts. Journal of Biological Chemistry 11/2012; 287(53). DOI:10.1074/jbc.M112.421255

79. Matteo Vecellio, Viviana Meraviglia, Simona Nanni, Andrea Barbuti, Angela Scavone, Dario

Difrancesco, Antonella Farsetti, Giulio Pompilio, Gualtiero I Colombo, Maurizio C

Capogrossi, Carlo Gaetano, Alessandra Rossini: In Vitro Epigenetic Reprogramming of Human

Cardiac Mesenchymal Stromal Cells into Functionally Competent Cardiovascular Precursors. PLoS

ONE 12/2012; 7(12):e51694. DOI:10.1371/journal.pone.0051694

80. Francesco Spallotta, Chiara Cencioni, Stefania Straino, Simona Nanni, Jessica Rosati, Simona

Artuso, Isabella Manni, Claudia Colussi, Giulia Piaggio, Fabio Martelli, Sergio Valente,

Antonello Mai, Maurizio C Capogrossi, Antonella Farsetti, Carlo Gaetano: A Nitric Oxide‐

dependent Crosstalk Between Class I and III Histone Deacetylases Accelerates Skin Repair. Journal of

Biological Chemistry 03/2013; 288(16). DOI:10.1074/jbc.M112.441816

81. Simona Nanni, Aurora Aiello, Agnese Re, Alessandro Guffanti, Valentina Benvenuti, Claudia

Colussi, Luis Jaime Castro‐Vega, Armando Felsani, Arturo Londono‐Vallejo, Maurizio C

Capogrossi, Silvia Bacchetti, Carlo Gaetano, Alfredo Pontecorvi, Antonella Farsetti: Estrogen‐

22

Dependent Dynamic Profile of eNOS‐DNA Associations in Prostate Cancer. PLoS ONE 05/2013;

8(5):e62522. DOI:10.1371/journal.pone.0062522

82. Francesco Spallotta, Silvia Tardivo, Simona Nanni, Jessica D Rosati, Stefania Straino,

Antonello Mai, Matteo Vecellio, Sergio Valente, Maurizio C Capogrossi, Antonella Farsetti,

Julie Martone, Irene Bozzoni, Alfredo Pontecorvi, Carlo Gaetano, Claudia Colussi: Detrimental

Effect of Class Selective Histone Deacetylase Inhibitors During Tissue Regeneration Following Hind‐

limb Ischemia. Journal of Biological Chemistry 07/2013; 288(32). DOI:10.1074/jbc.M113.484337

83. Germana Zaccagnini, Biagina Maimone, Valeria Di Stefano, Pasquale Fasanaro, Simona Greco,

Alessandra Perfetti, Maurizio C Capogrossi, Carlo Gaetano, Fabio Martelli: Hypoxia‐Induced

miR‐210 Modulates Tissue Response to Acute Peripheral Ischemia. Antioxidants & Redox

Signaling 08/2013; 21(8). DOI:10.1089/ars.2013.5206

84. Alessandra Magenta, Simona Greco, Carlo Gaetano, Fabio Martelli: Oxidative Stress and

MicroRNAs in Vascular Diseases. International Journal of Molecular Sciences 09/2013;

14(9):17319‐46. DOI:10.3390/ijms140917319

85. Chiara Cencioni, Francesco Spallotta, Fabio Martelli, Sergio Valente, Antonello Mai, Andreas

M Zeiher, Carlo Gaetano: Oxidative Stress and Epigenetic Regulation in Ageing and Age‐Related

Diseases. International Journal of Molecular Sciences 09/2013; 14(9):17643‐63.

DOI:10.3390/ijms140917643

86. Francesco Spallotta, Chiara Cencioni, Stefania Straino, Gianluca Sbardella, Sabrina Castellano,

Maurizio C Capogrossi, Fabio Martelli, Carlo Gaetano: Enhancement of lysine acetylation

accelerates wound repair. Communicative & integrative biology 09/2013; 6(5):e25466.

DOI:10.4161/cib.25466

87. Simona Greco, Carlo Gaetano, Fabio Martelli: HypoxamiR Regulation and Function in Ischemic

Cardiovascular Diseases. Antioxidants & Redox Signaling 09/2013; 21(8).

DOI:10.1089/ars.2013.5403

88. Emily Borretto, Loretta Lazzarato, Francesco Spallotta, Chiara Cencioni, Yuri DʹAlessandra,

Carlo Gaetano, Roberta Fruttero, Alberto Gasco: Synthesis and Biological Evaluation of the First

Example of NO‐Donor Histone Deacetylase Inhibitor. ACS Medicinal Chemistry Letters 10/2013;

4(10):994‐9. DOI:10.1021/ml400289e

89. Matteo Vecellio, Francesco Spallotta, Simona Nanni, Claudia Colussi, Chiara Cencioni, Anja

Derlet, Beatrice Bassetti, Manuela Tilenni, Maria Cristina Carena, Antonella Farsetti, Gianluca

Sbardella, Sabrina Castellano, Antonello Mai, Fabio Martelli, Giulio Pompilio, Maurizio C

Capogrossi, Alessandra Rossini, Stefanie Dimmeler, Andreas M Zeiher, Carlo Gaetano: The

Histone Acetylase Activator Pentadecylidenemalonate 1b Rescues Proliferation and Differentiation in

Human Cardiac Mesenchymal Cells of Type 2 Diabetic Patients. Diabetes 01/2014; 63(6).

DOI:10.2337/db13‐0731

23

90. Armando Felsani, Bjarki Gudmundsson, Simona Nanni, Elena Brini, Anna Moles, Hans

Guttormur Thormar, Peter Estibeiro, Carlo Gaetano, Maurizio Capogrossi, Antonella Farsetti,

Jon Johannes Jonsson, Alessandro Guffanti: Impact of different ChIP‐Seq protocols on DNA

integrity and quality of bioinformatics analysis results. Briefings in Functional Genomics 02/2014;

14(2). DOI:10.1093/bfgp/elu001

91. Alessandra Magenta, Simona Greco, Maurizio C Capogrossi, Carlo Gaetano, Fabio Martelli:

Nitric Oxide, Oxidative Stress, and p66 Shc Interplay in Diabetic Endothelial Dysfunction. Biomed

Res Int. 2014:193095. doi: 10.1155/2014/193095

92. Chiara Cencioni, Francesco Spallotta, Simona Greco, Fabio Martelli, Andreas M Zeiher, Carlo

Gaetano: Epigenetic mechanisms of hyperglycemic memory. The International Journal of

Biochemistry & Cell Biology 04/2014; 51(1). DOI:10.1016/j.biocel.2014.04.014

93. Alessandra Perfetti, Simona Greco, Enrico Bugiardini, Rosanna Cardani, Paola Gaia, Carlo

Gaetano, Giovanni Meola, Fabio Martelli: Plasma microRNAs as biomarkers for myotonic

dystrophy type 1. Neuromuscular Disorders 06/2014; 24(6). DOI:10.1016/j.nmd.2014.02.005

94. Mario Baumgart, Marco Groth, Steffen Priebe, Aurora Savino, Giovanna Testa, Andreas Dix,

Roberto Ripa, Francesco Spallotta, Carlo Gaetano, Michela Ori, Eva Terzibasi Tozzini,

Reinhard Guthke, Matthias Platzer, Alessandro Cellerino: RNA‐seq of the aging brain in the

short‐lived fish N. furzeri – conserved pathways and novel genes associated with neurogenesis. Aging

cell 07/2014; DOI:10.1111/acel.12257

95. Zhihui Liu, Wenling Li, Xuefei Ma, Nancy Ding, Francesco Spallotta, Eileen Southon, Lino

Tessarollo, Carlo Gaetano, Yoh‐Suke Mukoyama, Carol J Thiele: Essential Role of the Zinc

Finger Transcription Factor Casz1 for Mammalian Cardiac Morphogenesis and Development. Journal

of Biological Chemistry 09/2014; 289(43). DOI:10.1074/jbc.M114.570416

96. Viviana Meraviglia, Valerio Azzimato, Luca Piacentini, Mattia Chiesa, Rupesh K Kesharwani,

Caterina Frati, Maurizio C Capogrossi, Carlo Gaetano, Giulio Pompilio, Gualtiero I Colombo,

Alessandra Rossini: Syngeneic Cardiac and Bone Marrow Stromal Cells Display Tissue‐Specific

microRNA Signatures and microRNA Subsets Restricted to Diverse Differentiation Processes. PLoS

ONE 09/2014; 9(9):e107269. DOI:10.1371/journal.pone.0107269

97. Chiara Cencioni, Francesco Spallotta, Antonello Mai, Fabio Martelli, Antonella Farsetti,

Andreas M Zeiher, Carlo Gaetano: Sirtuin function in aging heart and vessels. Journal of

Molecular and Cellular Cardiology 01/2015; 83. DOI:10.1016/j.yjmcc.2014.12.023

98. Francesca Prandi, Marco Piola, Monica Soncini, Claudia Colussi, Yuri D’Alessandra, Eleonora

Penza, Marco Agrifoglio, Maria Cristina Vinci, Gianluca Polvani, Carlo Gaetano, Gianfranco

Beniamino Fiore, Maurizio Pesce: Adventitial Vessel Growth and Progenitor Cells Activation in an

24

Ex Vivo Culture System Mimicking Human Saphenous Vein Wall Strain after Coronary Artery

Bypass Grafting. PLoS ONE 02/2015; DOI:10.1371/journal.pone.0117409

99. Viviana Meraviglia, Valerio Azzimato, Claudia Colussi, Maria Cristina Florio, Anna Binda,

Alice Panariti, Khaled Qanud, Silvia Suffredini, Laura Gennaccaro, Michele Miragoli, Andrea

Barbuti, Paul D Lampe, Carlo Gaetano, Peter P Pramstaller, Maurizio C Capogrossi, Fabio A

Recchia, Giulio Pompilio, Ilaria Rivolta, Alessandra Rossini: Acetylation mediates Cx43 reduction

caused by electrical stimulation. Journal of Molecular and Cellular Cardiology 08/2015;

DOI:10.1016/j.yjmcc.2015.08.001

100. A Re, S Nanni, A Aiello, S Granata, C Colussi, G Campostrini, S Mattiussi, C D’Angelo, A

Biroccio, A Rossini, A Barbuti, D Di Francesco, F Trimarchi, A Pontecorvi, C Gaetano, and A

Farsetti: Anacardic acid and thyroid hormone enhance cardiomyocytes production from

undifferentiated mouse ES cells along functionally distinct pathways. Endocrine 2015, (in press).

101. Germana Zaccagnini, Anna Palmisano, Tamara Canu, Biagina Maimone, Francesco M. Lo

Russo, Federico Ambrogi, Carlo Gaetano, Francesco De Cobelli, Alessandro Del Maschio,

Antonio Esposito, Fabio Martelli: Magnetic resonance imaging allows the evaluation of tissue

damage and regeneration in a mouse model of critical limb ischemia. Plos One 2015 (in press).

102. Viviana Meraviglia, Jianyan Wen, Luca Piacentini, Giulia Campostrini, Cheng Wang, Maria

Cristina Florio, Valerio Azzimato, Lorenzo Fassina, Martin Langes, Johnson Wong, Michele

Miragoli, Carlo Gaetano, Giulio Pompilio, Andrea Barbuti, Dario DiFrancesco, Deborah

Mascalzoni, Peter P. Pramstaller, Gualtiero I. Colombo, Huei‐Sheng Vincent Chen, Alessandra

Rossini: Higher cardiogenic potential of iPSCs derived from cardiac versus skin stromal cells.

Frontiers in Biosciences 2015 ( in press).

Manuscripts submitted

1. Valente Sergio, Mellini Paolo, Spallotta Francesco, Carafa Vincenzo, Nebbioso Angela, Polletta

Lucia, Carnevale Ilaria, Saladini Serena, Trisciuoglio Daniela, Gabellini Chiara, Tardugno

Maria, Zwergel Clemens, Cencioni Chiara, Atlante Sandra, Moniot Sébastien, Steegborn

Clemens, Budriesi Roberta, Tafani Marco, Del Bufalo Donatella, Altucci Lucia, Gaetano Carlo,

Mai Antonello: 1,4‐Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair

and Mitochondrial Function, and Exhibit Inhibition of Proliferation in Cancer Cells. Submitted,

2015.

2. Davide Garella, Sandra Atlante, Emily Borretto, Mattia Cocco, Marta Giorgis, Annalisa

Costale, Antonella Di Stilo, Gianluca Miglio, Chiara Cencioni, Eli Fernández‐de Gortari, José L.

25

Medina‐Franco, Francesco Spallotta, Carlo Gaetano, Massimo Bertinaria: Chemical modulation

of NSC137546 scaffold toward improved inhibitors of DNA methylation. Submitted, 2015.

Invited Lectures (Selected)

1. 1995 Invited Speaker, UCSF, Host: Prof. Mark Israel, San Francisco, Ca, USA.

2. 1996 Invited Speaker, European Institute of Oncology (IEO), Host: Prof. PierPaolo Di Fiore,

Milan, Italy

3. 1999 Invited Speaker, Favaloro University, Host: Prof. René G. Favaloro, Buenos Aires,

Argentina.

4. 2005 Invited Speaker, The British Society for Cardiovascular Research Conference, Host: Prof.

Qingbo Xu, Oxford, UK

5. 2007 Invited Speaker, King´s College London, Host: Prof. Qingbo Xu, London, UK

6. 2008 Invited Speaker, Seminari Biologici Series, Catholic University, Host: Prof. Tommaso

Galeotti, Rome, Italy

7. 2009 Invited Speaker, Medical Research Council‐University College London, Host: Dr.

Antonella Riccio, London, UK

8. 2009 Organizer & Lecturer, National Cancer Institute Regina Elena, Workshop “Epigenetics

in Rome: Breaking news from the Chromatin Remodeling and Human Disease”, Rome, Italy

9. 2010 Invited Speaker, Burnham Institute, Host: Prof. Vincent Chen, S. Diego, Ca, USA

10. 2010 Invited Speaker, Royal Bristol Infirmary, Bristol University, Bristol, UK

11. 2011 Invited Speaker FASEB Meeting Histone Deacetylases & Reversible Acetylation in

Signaling & Disease, Steamboat Springs, Colorado USA

12. 2011 Invited Speaker, European Society of Cardiology (ESC) Congress 2011,Paris, France

13. 2012 Invited Speaker, University of Fribourg, “Vascular Progenitors in Biology and Medicine

Meeting”, Fribourg, Switzerland

14. 2013 Invited Speaker, San Donato Hospital IRCCS, Host: Dr. Fabio Martelli, Milan, Italy

26

15. 2013 Invited Speaker, Leiden University, Host: Prof. Paul Quax, Leiden, The Netherland

16. 2014 Invited Speaker, NIH/National Cancer Institute, Host: Prof. Carol J. Thiele, Bethesda,

USA

17. 2014 Chairman, German Centre for Cardiovascular Research (DZHK), Symposium on

Epigenetics, Host: Prof. Andreas Zeiher, Berlin, Germany

18. 2015 Invited Speaker, German Heart Center at the TU Munich, Symposium on ʺRedox stress

and epigenetics in cardiovascular diseasesʺ, Host: Prof. Agnes Görlach, Munich, Germany

19. 2015 Invited Speaker, IFOM‐IEO Campus, Host: Prof. PierPaolo Di Fiore, Milan, Italy

20. 2015 Invited Speaker Euro Global Diabetes Summit and Medicare Expo, Host: Prof. Massimo

Collino, Valencia, Spain

Contribution to American Heart Scientific Sessions (Accepted abstracts)

(1‐31)

1. Palumbo, R., Gaetano, C., Melillo, G., Toschi, E., Remuzzi, A., and Capogrossi, M. C. (2000)

Shear Stress Downregulation of Platelet-Derived Growth Factor Receptor-β and Matrix

Metalloprotease-2 Is Associated With Inhibition of Smooth Muscle Cell Invasion and

Migration. Circulation 102, 225-230

2. Zaccagnini, G., Martelli, F., Fasanaro, P., Magenta, A., Gaetano, C., Di Carlo, A., Biglioli, P.,

Giorgio, M., Martin-Padura, I., Pelicci, P. G., and Capogrossi, M. C. (2004) p66ShcA Modulates

Tissue Response to Hindlimb Ischemia. Circulation 109, 2917-2923

3. Colussi, C., Illi, B., Straino, S., Capogrossi, M. C., and Gaetano, C. (2007) Abstract 1274:

Altered Chromatin Landscape Provides Molecular Basis for Endothelial Dysfunction in

Duchenne Muscle Dystrophy. Circulation 114, II_240

4. Grasselli, A., Nanni, S., Colussi, C., Sacchi, A., Gaetano, C., Pontecorvi, A., Capogrossi, M. C.,

and Farsetti, A. (2007) Abstract 1396: Nitric Oxide is Required for Estrogen Regulation of

hTERT Expression and Telomerase Activity in Human Endothelial Cells. Circulation 114,

II_266-II_267

5. Illi, B., Colussi, C., Martelli, F., Capogrossi, M. C., and Gaetano, C. (2007) Abstract 354: Nitric

Oxide Regulates Chromatin Folding in Human Endothelial Cells via PP2A activation and

HDAC-4 Nuclear Shuttling. Circulation 114, II_45-II_46

27

6. Illi, B., Spallotta, F., Mattiussi, S., Capogrossi, M. C., and Gaetano, C. (2007) Abstract 301:

Epigenetic Reprogramming during SS-dependent Differentiation of Mouse Embryonic Stem

Cells: Role of Nitric Oxide and Histone Deacetylases. Circulation 114, II_32

7. Illi, B., Spallotta, F., Rosati, J., Mattiussi, S., Nanni, S., Rotili, D., Valente, S., Mai, A., Farsetti,

A., Capogrossi, M. C., and Gaetano, C. (2007) Abstract 692: Class II HDACs Are Required

During Early Stage Mouse Embryonic Stem Cell Differentiation in Response to Nitric Oxide.

Circulation 116, II_129

8. Rossini, A., Scopece, A., Pozzoli, O., Pompilio, G., Gaetano, C., Capogrossi, M. C., and

Germani, A. (2007) Abstract 1015: Human Heart Contains A Stem Cell Population With

Mesenchymal Properties. Circulation 116, II_202

9. Colussi, C., Berni, R., Bocchi, L., Savi, M., Delucchi, F., Stilli, D., Quaini, F., Musso, E.,

Capogrossi, M. C., and Gaetano, C. (2008) Abstract 3861: Histone Deacetylase Inhibitors

Ameliorate Cardiac Electrical Competence In Dystrophic Mice. Circulation 118, S_494

10. Colussi, C., Straino, S., Illi, B., Rosati, J., Vitale, S., Capogrossi, M. C., and Gaetano, C. (2008)

Abstract 1822: Epigenetic Parallelism Between Hindlimb Ischemia And Duchenne Muscular

Dystrophy Revealed By Global Histone Modification Profiling. Circulation 118, S_392

11. Rosati, J., Spallotta, F., Vincenti, S., Arcelli, D., Presutti, C., Capogrossi, M. C., Gaetano, C.,

and Illi, B. (2008) Abstract 3832: Mir429 Regulates NO-dependent Differentiation Of Mouse

Embryonic Stem Cells. Circulation 118, S_493

12. Rossini, A., Scopece, A., Pompilio, G., Gaetano, C., and Capogrossi, M. C. (2008) Abstract 302:

Cardiac Stromal Cells Response to Lineage-Specific Differentiation Signals Reveals

Commitment to a Cardiovascular Differentiation Default Program. Circulation 118, S_280-

S_281

13. Gaetano, C., Colussi, F. C., Scopece, M. A., Mattiussi, S., Vitale, S., Rosati, J., Illi, B., and

Capogrossi, M. C. (2009) Abstract 5648: Epigenetic Basis of Nitrate Tolerance: Fundamental

Role of Protein Acetylation. Circulation 120, S1133-S1134

14. Rosati, J., Spallotta, F., Vincenti, S., Presutti, C., Capogrossi, M. C., Gaetano, C., and Illi, B.

(2009) Abstract 2111: SIP1/ZEB2 Targeting by the Nitric Oxide-dependent miR200 Family is

28

Important for Early Mesodermic/Cardiovascular Commitment of Mouse Embryonic Stem

Cells. Circulation 120, S595

15. Rossini, A., Frati, C., Lagrasta, C., Graiani, G., Scopece, A., Cavalli, S., Pompilio, G., Quaini, F.,

Gaetano, C., and Capogrossi, M. C. (2009) Abstract 3230: Cardiac Stromal-derived Cells

Reveal Higher Proficiency to Myocardial Regeneration Than Bone Marrow Mesenchymal

Cells With Identical Genetic Background. Circulation 120, S766

16. Rossini, A., Vecellio, M., Scopece, A., Di Rocco, G., Pompilio, G., Capogrossi, M. C., and

Gaetano, C. (2009) Abstract 3224: MicroRNA Profiling of Cardiac and Bone Marrow Stromal

Cells With Identical Genetic Background Reveals Distinctive Signatures Unmodulated by

Differentiation Stimuli. Circulation 120, S764

17. Spallotta, F., Rosati, J., Straino, S., Ambrosino, V., Rotili, D., Valente, S., Mai, A., Capogrossi,

M. C., Gaetano, C., and Illi, B. (2009) Abstract 5852: Nitric Oxide Determines Mesodermic

Differentiation of Mouse Embryonic Stem Cells Activating Class II Histone Deacetylases:

Consequences for Post-ischemia Hindlimb Regeneration. Circulation 120, S1162

18. Burba, I., Colombo, G. I., Staszewsky, L. I., Devanna, P., De Simone, M., Avitabile, D., Molla,

F., Russo, I., De Angelis, N., Gambini, E., Spada, D., Biondi, A., Gaetano, C., Pompilio, G.,

Latini, R., C. Capogrossi, M., and Pesce, M. (2010) Abstract 14311: Enhanced Cardioprotection

by Histone Deacetylase Inhibitor Valproic Acid-preconditioned Human Cord Blood (UCB)-

Derived CD34+ Cells. Circulation 122, A14311

19. Colussi, C., Rosati, J. D., Straino, S., Spallotta, F., Berni, R., Stilli, D., Rossi, S., Musso, E.,

Macchi, E., Mai, A., Altucci, L., Quaini, F., Tremoli, E., Capogrossi, M. C., and Gaetano, C.

(2010) Abstract 10140: Lysine Acetylation Determines Dissociation From GAP-Junctions and

Lateralization of Connexin 43 in Normal and Dystrophic Heart. Circulation 122, A10140

20. Vecellio, M., Pompilio, G., Di Rocco, G., Capogrossi, M. C., Gaetano, C., and Rossini, A. (2010)

Abstract 12218: In Vitro Production of Niche-like Precursors by Epigenetic Reprogramming of

Stroma-Derived Cardiac Cells. Circulation 122, A12218

21. Colussi, C., Rosati, J., Tardivo, S., Mai, A., Capogrossi, M. C., and Gaetano, C. (2011) Abstract

10655: Fundamental Role for Class IIa Histone Deacetylases in the Regulation of Myo-miRs

Expression Following Hind-Limb Ischemia and Muscle Regeneration. Circulation 124, A10655

29

22. Nanni, S., Re, A., Benvenuti, V., Aiello, A., Rosati, J., Colussi, C., Gaetano, C., Bacchetti, S.,

Pontecorvi, A., Capogrossi, M. C., and Farsetti, A. (2011) Abstract 12662: A Genome-Wide

Analysis of eNOS-Binding DNA Regions Reveals Unprecedented Regulatory Elements

Important for Estrogen Transcriptional Response in Human Endothelial Cells. Circulation 124,

A12662

23. Vecellio, M., Florio, M. C., Nanni, S., Farsetti, A., Pompilio, G., Di Francesco, D., Barbuti, A.,

Capogrossi, M. C., Rossini, A., and Gaetano, C. (2011) Abstract 11827: Cardiac Stromal Cell

Reprogramming to Functional Cardiovascular Precursors via Epigenetic Intervention.

Circulation 124, A11827

24. Vecellio, M., Pompilio, G., Spallotta, F., Colussi, C., Sbardella, G., Castellano, S., Mai, A.,

Capogrossi, M. C., Rossini, A., and Gaetano, C. (2011) Abstract 11858: Epigenetic Reversion of

Metabolic Memory Alterations in Human Cardiac Stromal Cells Isolated from Type-2 Diabetic

Patients. Circulation 124, A11858

25. Colussi, C., Spallotta, F., Nanni, S., Rosati, J. D., Tardivo, S., Straino, S., Mai, A., Capogrossi, M.

C., Farsetti, A., and Gaetano, C. (2012) Abstract 12479: Class I and II Histone Deacetylases

Orchestrate Muscle Regeneration Program Following Hind-limb Ischemia. Circulation 126,

A12479

26. Meraviglia, V., Azzimato, V., Kesharwani, R. K., Capogrossi, M. C., Gaetano, C., Pompilio, G.,

Colombo, G. I., and Rossini, A. (2013) Abstract 14715: Syngeneic Cardiac and Bone Marrow

Stromal Cells Display Tissue-Specific microRNA Signatures and microRNA Subsets Restricted

to Diverse Differentiation Processes. Circulation 128, A14715

27. Prandi, F., Piola, M., Soncini, M., Colussi, C., Penza, E., Agrifoglio, M., Polvani, G. L., Gaetano,

C., Fiore, G. B., and Pesce, M. (2013) Abstract 11456: Pressure-Driven Remodeling in Human

Saphenous Veins: Evidences of Mechano-Epigenetic Effects in Intima Hyperplasia Associated

to Coronary Artery By-Pass Grafting. Circulation 128, A11456

28. Azzimato, V., Meraviglia, V., Colussi, C., Florio, M. C., Panariti, A., Qanud, K., Gaetano, C.,

Pramstaller, P. P., Capogrossi, M. C., Pompilio, G., Recchia, F. A., Rivolta, I., and Rossini, A.

(2014) Abstract 13799: Electrical Pacing Inhibits Gap Junction-Mediated Cardiac Cell -Cell

Communication by Promoting Cx43-Acetylation. Circulation 130, A13799

30

29. Cencioni, C., Savoia, M., Spallotta, F., Kuenne, C., Guenther, S., Zeiher, A. M., and Gaetano,

C. (2014) Abstract 13123: Noncoding RNAs in Early Mouse Embryonic Stem Cell Commitment

to Cardiovascular Precursors. Circulation 130, A13123

30. Meraviglia, V., Wen, J., Piacentini, L., Campostrini, G., Wang, C., Azzimato, V., Wong, J.,

Gaetano, C., Pompilio, G., Barbuti, A., DiFrancesco, D., Pramstaller, P. P., Colombo, G. I.,

Chen, V. H., and Rossini, A. (2014) Abstract 12965: Higher Cardiac Differentiation Properties

are Evident in Long Term Cultured Induced Pluripotent Stem Cells Obtained From Atrial

Mesenchymal Cells Compared to Skin Mesenchymal Cells. Circulation 130, A12965

31. Spallotta, F., Cencioni, C., Farsetti, A., Zeiher, A. M., and Gaetano, C. (2014) Abstract 18405:

Epidrug Treatment Rescues Proliferation and Differentiation in Human Cardiac Mesenchymal

Cells of Type 2 Diabetic Patients: A Case of Epimetabolic Memory. Circulation 130, A18405

Contribution to American Heart Scientific Sessions

(Sessionorganizer/Moderator/Invited presenter)

2008‐ Session Organizer & presenter: Epigenetics and Cardiovascular System

2009‐ Session Moderator: Genetics, Genomics and Congenital CV Disorders

2010‐ Invited presenter: Genetic and Epigenetic Specification of Cardiovascular Diseases

curriculum vitae -carlo gaetano-november_18th_ 2015_new

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