Curriculum vitae : Alexey Zaikin, Dr.rer.nat.habil., PhD

Personal Name: Zaikin, Alexey Languages: English, German, Russian, Spanish Nationality: Russian Address: Institute for Women’s Health and

Dep. of Mathematics University College London, Gower Street London, WC1E 6BT, UK

Email: alexey.zaikin@ucl.ac.uk Tel.: +44 20 76794375 Web: http://www.zaikinlab.com

Education 05.2003 Habilitation, Theoretical Physics, Potsdam University, Germany, "Noise-induced transitions and

resonant effects in nonlinear systems". 02.1998 Ph.D. Physics&Mathematics, Moscow State University, Russia,"Noise-induced phase transitions

and control of turbulence in submerged jets by acoustical influence", Advisor: Prof. P.S. Landa. 01.1995 M.S. Physics (with distinction), Moscow State University, Russia, "Nonlinear dynamics of

resonators and flows under acoustical influence", Advisor: Prof. O.V. Rudenko. 09.1989 School 711, Moscow, (with distinction). Positions 09.2008- Chair, Professor of Systems Medicine and Applied Mathematics, Institute for Women’s Health

and Department of Mathematics, University College London, UK 01.2007-08.2008 Senior lecturer in Systems Biology, Departments of Biological and Department of Mathematical

Sciences, Essex University, UK. 01.2005-12.2008 Project leader “Stochastic modeling of the proteasome and its application to cancer therapy",

funded by VW-foundation, Potsdam University, Germany. 01.2004-12.2004 Lecturer in Applied Mathematics, Department of Mathematics, Exeter University, UK. 06.2003-12.2003 Postdoc, Institute of Biochemistry, Charité, Humboldt University, Berlin, Germany. 01.2001-06.2003 Postdoc, Potsdam University, European Space Agency project: "2D and 3D Quantification of Bone

Structure and its Changes in Microgravity Condition by Measures of Complexity", Germany. 2000,01,02,06 Visiting scientist(1-2 mths/year) HPC-EU-program, Universitat Politecnica de Catalunya, Spain. 01.1999-12.2000 Postdoctoral Researcher, Max-Planck-Gesellschaft Fellowship, Potsdam University, Germany. 01.1997-12.1998 Visiting scientist, Humboldt University in Berlin, Prof. L. Schimansky-Geier, Germany. 04.1995-12.1996 Visiting scientist, Potsdam University, Prof. J. Kurths, Germany. 03.1995-02.1998 PhD student, Moscow State University, Prof. P.S. Landa, Russia. Research Interests Computational and Systems Medicine, Systems Biology, Synthetic Biology, Biomedicine, Theoretical Biophysics, Applied Mathematics, Statistical Physics, Nonlinear Dynamics and Stochastic Modeling in Biology, in particular: 2008-present Systems medicine of women’s cancer, modeling genetic networks, data analysis of –omics data, 2005-present Systems immunology, Modelling proteasome function and Proteasomal splicing, 2003-present Application of stochastic modeling and nonlinear dynamics in molecular biology, especially to model

gene expression, epigenetic cell differentiation, circadian and synthetic genetic oscillators, 2000-2003 Nonlinear dynamics and stochastic modeling in medicine: quantification of bone structures with

structural complexity measures, modeling of bone reconstruction, 1995-present Stochastic processes, noise-induced phenomena in spatially extended systems, stochastic resonance,

phase transitions, coherence resonance, doubly stochastic effects, system size effects, ratchets, control of turbulence, stochastic phenomena in neural models, noise-induced effects in electronic circuits (also experimentally),

1993-1996 Nonlinear acoustics, Turbulence and Hydrodynamics, Cognitive Complexity, Polyrhythm generation.

Teaching (13.06.2013: over 459 lectures in UK/Germany/Russia) 2010- Lectures (3 modules of 24 lectures), Probability and Statistics for Systems Biology, CoMPLEX, UCL 2008- Lectures (9 semester modules) Biomathematics, Population Genetics and Evolutionary Games , UCL 2007-2008 Lectures (5 semester modules) e.g. "Basic Molecular Biology", different math. courses, Essex 2004 Lectures (3 semester modules) and tutorials at the University of Exeter, e.g. "Advanced Differential

Equations and Chaos", “Calculus”, “Dynamics, Numerics and Control”. 2002 Lectures "Stochastische Prozesse und stochastische Differentialgleichungen in der Biologie,

Erdsystem-Modellierung und Ökonomie", Potsdam University (in German). 2001/2002 Lectures "Noise-induced order in nonlinear systems", MPI Golm School on Biomimetic Systems. 2001 Seminars on theoretical physics, Potsdam University, 2000/2001 Lectures "Noise-induced order in nonlinear systems", Potsdam University, 2000 Tutorship on theoretical physics, Potsdam University, 1996 Tutorship in acoustical lab, Moscow State University, Awards and Grants 2012 UCL CR-UK Cancer Centre Development Fund, with Stephen Pollard (£20,000) 2011- CR-UK and Eve Appeal grant, “Risk Stratification, Early Detection and Diagnosis of Ovarian Cancer”,

Co-I, PI - Prof. I. Jacobs, (total £1.6M) 2010 Co-A of Master program in Synthetic Biology (2010 onwards, lead by Prof.J. Ward), funded by BBSRC 2010 LMS Scheme 2 Grant, visit of Prof. E. Volkov (£1000) 2005-2007 PI, “Stochastic modeling of the proteasome and its application to cancer therapy”, VW-grant (191.500 Euro) 2000-2006 (26 weeks) EU program, HPC-Europa Access grant to visit Cesca-Cepba centre in Spain ( 13.000 Euro) 1999 Max-Planck-Gesellschaft fellowship 1998 Best Paper Award, Int. Conference on Computing Anticipatory Systems, Liege, Belgium 1996 DAAD-Prize for outstanding research, Potsdam University 1995 Khokhlov Award for Excellence in Research, Moscow State University 1989 Silver medal, School 711, Moscow Supervision of Ph.D students: 2008- R. Heussen, Y. Borg, T. Bartlett, UCL, (currently supervised). 2008-2013 R. Bilal, UCL, “Dynamics of gene regulatory networks in the immune system” 2009-2012 E.A.G. Long, UCL,”Modelling microdomain-mediated protein sorting in immunological signaling”. 2009-2011 N.R. Nene, UCL, “Intracellular network attractor selection and the problem of cell fate decision”. 2005-2008 M. Ruskoni, Potsdam University, “Stochastic modelling of bone formation and adaptation". 2005-2007 A. Koseska, Potsdam University, “Control of gene expression in ensemble of genetic oscillators". 2001-2004 E. Ullner, (with distinction), Potsdam University, “Noise-induced phenomena…".

Partial supervision: E. Glatt (Darmstadt university), C. Tessone (Palma de Mallorca), A. Mitra (Potsdam) Conference Presentations >100 (31 invited) in UK, Germany, Russia, Italy, Spain, France, USA, Australia, Benelux, Sweden, India. Publications 91 scientific publications (77 in refereed journals), h-index=21(Google), 20 (Scopus) 19 (Web), in particular: 5 selected in Systems Biology and Medicine (IF-impact factor): 1. J. Liepe, M. Mishto, K. Textoris-Taube, K. Janek, C. Keller, P. Henklein, P.M. Kloetzel, and A. Zaikin, “The 20S

Proteasome Splicing Activity Discovered by SpliceMet”, PLOS Computational Biology, Vol. 6, e1000830 (2010). IF-5.8.

2. M. Widschwendter, A.N. Rosenthal, S. Philpott, M.I. Rizzuto, L. Fraser, J. Hayward, M.P. Intermaggio, C.K. Edlund, S.J. Ramus, S. A. Gayther, L. Dubeau, E.O. Fourkala, A. Zaikin, U. Menon, and I. J. Jacobs, “The sex hormone system in BRCA1/2 mutation-carriers: a case-control study”, The Lancet Oncology 14, 1226 (2013), IF=25.11.

3. E. Ullner, A. Zaikin, E.I. Volkov,and J. Garcia-Ojalvo, "Multistability and Clustering in a Population of Synthetic Genetic Oscillators via Phase-Repulsive Cell-to-Cell Communication", Phys.Rev.Lett. 99, 148103 (2007). IF-7.3.

4. N. Nene, J. Garcia-Ojalvo, and A. Zaikin, “Speed-dependent cellular decision making in nonequilibrium genetic circuits”, PLoS ONE 7, e32779 (2012), IF=4.09.

5. M. Ruskoni, A. Zaikin, N. Marwan, and J. Kurths, "Effect of Stochastic Resonance on Bone Loss in Osteopenic Conditions” Phys. Rev. Lett. 100, 128101 (2008). IF-7.3.

5 selected in Applied Mathematics and Statistical Physics, all about noise-induced phenomena (CI-citation index): 1. A. Zaikin, J. Kurths, and L. Schimansky-Geier, Phys. Rev. Lett. 85, 227(2000), IF-7.3, CI-78. 2. A. Zaikin, J. Garcia-Ojalvo, R.Bascones, E. Ullner, and J. Kurths, Phys. Rev. Lett. 90, 030601(2003), IF-7.3, CI-33. 3. E. Ullner, A. Zaikin, J. Garcia-Ojalvo, and J. Kurths, Phys. Rev. Lett. 91, 180601(2003), IF-7.3, CI-44. 4. A. Zaikin, J. Garcia-Ojalvo, L. Schimansky-Geier, and J. Kurths, Phys. Rev. Lett. 88,010601(2002), IF-7.3, CI-39. 5. A. Pikovsky, A.Zaikin, and M.A. de la Casa, Phys. Rev. Lett. 88, 050601(2002), IF-7.3, CI-81.