ct, mri and ultrasound of the orbit€¦ · magnetic resonance imaging diagnostic ultrasound pixel...
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CT, MRI and Ultrasound of the Orbit
GABRIELA S SEILER DR.MED.VET. DECVDI, DACVR
PROFESSOR OF RADIOLOGY
NORTH CAROLINA STATE UNIVERSITY
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Orbital imagingPrinciples and Indications of Computed Tomography and Magnetic Resonance Imaging
Relevant Imaging Parameters
Imaging of Orbital Diseases with Case Examples
www.intechopen.com
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Tomographic Benefit
148533M
Exopthalmos, OSSquamous cell carcinoma
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Mixbreed dog, 1 year history of nasal and ocular discharge, initially responded to antibiotics
radiograph CT image
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Cross‐Sectional ImagingComputed Tomography
Magnetic Resonance Imaging
Diagnostic Ultrasound
Pixel ‐ picture elementVoxel ‐ volume element
Pixel
Voxel
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Principles of Cross‐sectional imaging
MODALITY
SPATIAL
RESOLUTION
CONTRAST RESOLUTION
Radiography <1 mm Good
Ultrasound 1-2mm Better
CT 0.4 mm Even better
MRI 1-3 mm Best!
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Computed Tomography “Cat Scan”
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Computed Tomography
First CT scanner was built by Sir Godfrey Hounsfield at the EMI Research Laboratories in 1972
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Anatomy of a CT scanner
X‐ray detectors
X‐ray tube
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Most CTs are helical or spiral CTs
X‐ray tube and an array of receptors rotate around the patient
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Image Reconstruction
Images acquired by rapid rotation of X‐ray tube 360°around patient as couch moves.
The transmitted radiation is then measured by a ring of radiation sensitive ceramic detectors.
An image is generated from these measurements
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Image ReconstructionComplex mathematical algorithms allow each voxel to
be assigned a numerical value based on the x ray attenuation within that volume of tissue.
Known as Hounsfield Unit
Sir Godfrey Hounsfield (1919‐2004)
1979 Nobel Laureate in Medicine
‘for the development of
computer assisted tomography’.
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The Hounsfield Scale
A 12‐bit number defines the scale. 212 = 4,096
Water is assigned a value of 0,
Air is assigned a value of ‐1,024.
Range is ‐1,024 for air (lung) to +3,071 for the densest object that can be measured by the CT scanner (compact bone).
Tissues of most clinical interest range from ‐100 to +100.
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Hounsfield Unit Measurements
Tissue HU
Bone 300 to 3000
Mineralized disc 100 to 300
Acute hemorrhage 42 to 58
Brain‐ gray matter 35
Brain‐ white matter 30
Water 0
Fat ‐50 to –100
Air ‐1000
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Digital Image DisplayNot all gray scale data can be differentiated by the human eye
Monitors can display 8 bits or 256 + shades of gray (color)
Human eye can perceive about 30‐50 shades of gray
Post processing techniques are applied to CT images to allow optimal evaluation
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Window WidthDescribes the range of Hounsfield Units (HU) displayed.
Lowest number in the window is displayed as black, highest number as white, everything in between is grouped into approximately 30 shades of gray.
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Window LevelDescribes the HU in the center of the window width
Example: ◦ A window level of 50 is centered on soft tissue, with a window width of 300, HU from ‐100 to +200 are displayed.
◦ Everything below ‐100 will be black, everything above will be white.
◦ Soft tissue contrast will be good as every 10HU has a different gray value
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Window level and width
WL: 50, WW: 300
Soft tissue window
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Image acquisition and display
Bone: WL 500, WW 2000 Soft tissue: WL 40, WW 400
CT images can be acquired with different kernels
Shades of gray can be re‐distributed in CT images by changing window level and width to better display bones or soft tissue
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Contrast medium administrationAlways use pre‐ and post contrast image series for brain and ocular imaging
Exception: orbital fracture evaluation, particularly in large animals
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Contrast resolution muchgreater than CTImage appearance dependent upon chemical compositionWater (free or in tissues)
Fat
No ionizing radiationImage in any plane
No reformatting
Longer scan times
Magnetic Resonance Imaging (MRI)
MRI
97331
CT
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MRI – how does it work?
Patient is placed in magnet
Radiowaves are pulsed in
Patient emits a signal
Signal is used to construct an image
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1.5 T = 15,000 Gauss (G) Earth’s magnetic field 0.5G(150 x stronger than a refrigerator magnet) – safety
concerns!
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MRI facts – all you need to know
We are imaging hydrogen protons (water, tissue, fat)
Protons themselves can act like mini magnets (moving nuclear proton induces a magnetic field – Faraday’s law of electromagnetic induction)
In “field free” space
randomly oriented
In the absence ofan external magnetic field, a proton rotates about its own axis and generates a magnetic field
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If you apply an external magnetic field to protons, the Net Magnetic Vector (NMV ~ average proton orientation) aligns with the magnetic field. The protons precess relative to the magnetic field strength.
Inside magnetic field
oriented with or against B0
M = net magnetization
M
B0
In an external magnetic field, B0 a proton rotates on its own axis and wobbles (precess) about the main magnetic field
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MRI – T1 Relaxation
Overall Magnetic Field
Signal
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MRI – T2 Decay
Signal
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A radiofrequency pulse is applied at a specific frequency. Some aligned protons absorb that energy (resonate) and align against the magnetic field.
When the pulse is turned off, the absorbed energy is released in the form of a radiofrequency pulse. The character of the energy release is determined by the tissue type (fluid vs fat vs grey matter etc) the H+ is in.
Numerous ‘pulse sequences’ are run modifying tissue excitation and signal capture (listening) parameters. From this data, images are created.
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Basic Sequences
T2 – fat, fluid and most pathology is bright (juicy)
Proton Density – anatomy + some pathology
T1 – fat is bright, fluid is dark – good anatomy
T1 – post C+ ‘enhancement’
T2 PD T1
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T1‐weigthed post contrast images
Pre Post – brainstem meningioma
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FLAIR = Fluid Attenuated Inversion Recovery
◦ Remove signal from true fluid (CSF, vitreous, urine etc)
◦ Increases conspicuity of periventricular pathology
T2 FLAIR
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Fat saturated imagesIn most sequences, fat is bright. Removing fat signal increases conspicuity of pathology
2 methods to remove fat signal ◦ STIR Short Tau Inversion Recovery
◦ Fat suppression
Equine distal metacarpal bone:
T2 ‐ normal
STIR – bone bruise visible as signal from marrow fat is suppressed.
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Common MRI Sequences
Name Signal Based On:
Water FAT
Proton Density
All Protons hyperintense hyperintense
T1 Protons in FAT hypointense hyperintense
T2 Protons in all WATER and
FAT
hyperintense hyperintense
FLAIR(Fluid Attenuated
Inversion Recovery)
Nulls signal from water
hypointense hyperintense
STIR(Short Tau Inversion Recovery)
Nulls signal from fat
hyperintense hypointense
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MRIUnparalleled contrast resolution
Modality of choice for most all neuro
disorders
Basic images are T2, PD and T1, but lots of image sequence options
High field magnets superior to low field
Physics is really complicated!
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Protocols for orbital imaging
CT MRI
Thin slices with bone algorithm
Thicker slices with soft tissue algorithm
Pre‐ and post contrast
Reformat images as needed
Minimum sequences:
T1 pre‐ and post contrast, at least one image plane with fat saturation – dorsal for orbit!
T2
Proton Density (PD)
FLAIR
Gradient echo for hemorrhage
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Slice alignment with the orbit improves sensitivity for subtle changes
Dorsal oblique=30‐33 deg to the hard palate
Oblique sagittal=33 deg (dog), 28 deg (cat) from sagittal
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CT vs. MRI
Good for osseous detail: ◦ Trauma (peracute intracranial hemorrhage )
◦ Aggressive bone lesions
◦ Dental disease
Good for nasal tumors with orbital extension◦ Because inherent contrast in nasal cavity
Insensitive/poor for soft tissue contrast/pathology
Highly insensitive for intracranial lesions
Best soft tissue contrast and highlights pathology◦ Best for intracranial extension of disease
◦ Involvement of the cranial nerves
Insensitive for subtle bone lesions
Thicker slices = less spatial resolution
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Orbital fractures MR vs. CT
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CT/MRI VS. ULTRASOUND
CT/MRI:
1. More global overview of the orbital structures
2. Can use contrast medium to differentiate tissues
3. CT‐guided aspirates
Ultrasound:
1. Limited window into the pterygopalatine fossa
2. No anesthesia required
3. Tissue sampling may be possible
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Dalmatian, 3rd eyelid prolapse, ocular reddening, reduced retropulsion of the right eye, EPISTAXIS
Ultrasound: retrobulbar mass
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Dalmatian, 3rd eyelid prolapse, ocular reddening, reduced retropulsion of the right eye, EPISTAXIS
CT: retrobulbar mass with bone lysis and extension into the nasal cavity
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Ocular diseases
CT and MRI are limited in image resolution and detail
Ultrasound is the method of choice
CT and MRI often chosen when other clinical signs are present as well
OS OD
Bilateral posterior lenticonus
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Ultrasound of retrobulbar abnormalitiesUse lower frequencies to look “deep” or adjacent to the eye
Uses: Masses, inflammation, foreign bodies….
Don’t forget to look at bone surface for lysis or proliferation
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Case – Two year old Bloodhound, acute onset of pain over right eye, mild exophthalmos
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Aspirate for culture results
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Guided aspirates or biopsy
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9 year old Mixed breed dog
Acute onset redness of right eye
Exophthalmos
Intraocular structures normal
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9 year old Mixed breed dog
Acute onset redness of right eye
Exophthalmos
Intraocular structures normal
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9 year old Mixed breed dog
Acute onset redness of right eye
Exophthalmos
Intraocular structures normal
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9 year old Mixed breed dog
Acute onset redness of right eye
Exophthalmos
Intraocular structures normal
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Zygomatic sialoadenitis
Zygomatic salivary gland adjacent to the eye
Normally these are difficult to see as they are small and inaccessible
Dog improved on antibiotics
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Labrador retriever 9y mcPresented for exophthalmos OD
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Zygomatic Sialadenitis and Pterygoid Myositis
Pituitary Mass
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CT and MRI of the orbit– image interpretationTake your time!
Know normal anatomy
Use symmetry to identify and interpret abnormalities
Look for:◦ Contrast enhancement
◦ Muscle atrophy
◦ Bone destruction
◦ Lymph node enlargement
◦ Disease extension into adjacent spaces – nasal cavity and brain
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CT and MRI of retrobulbar diseasesAbscess / Foreign bodies
Masticatory and extraocular muscle myositis
Sialadenitis/sialoceles
Neoplasia
Orbital fractures
Tooth root abscesses
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Labrador retriever male 5yMild exophthalmos and swelling behind the eye OS
Ocular discharge OS
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Pre‐contrast Post‐contrast
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Reformatted images
Reformatted images are very helpful to detect a geometrical shape of a suspected foreign body
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Wirehair pointer, mc, 3y
Had an encounter with a porcupine 4 months ago…Since then RDVM had been removing migrated quills from the head
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last 2 months progressive exophthalmos OD, pawing at face and sneezing
thickened scleraproptosis retrobulbar abscess
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Multiple contrast‐enhancing tracts in the right temporal muscle that are consistent with inflammatory tracts associated with porcupine quill penetration
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5yo Labrador Retriever, mc4 week history of nasal discharge, first clear then mucoid
Progressively worse
Now ocular discharge on the right
Mild epistaxis
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CT nose – bone window
Large amount of turbinate destruction
No mass seen
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CT +C
Periocular swelling
Thickened sclera and choroid
Increased density of the vitreous
Detached retina
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CT findingsBilateral destructive rhinitis, most consistent with fungal disease (aspergillosis)
Right ophthalmitis, chorioretinitis, vitreous body inflammation or hemorrhage, retinal detachment – suspect ocular aspergillosis
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Ocular aspergillosis
Can cause chorioretinitis and retinal detachment
Cellular infiltrates posterior to the detached retina have also been associated with other fungal diseases such as blastomycosis
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Norwegian forest cat, mc, 4y.
Upper airway noise
Reduced airflow from both nostrils
Left eye retropulses less than right
Suspicion of a nasal mass
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Bone algorithm: multifocal lysis
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Soft tissue algorithm: soft tissue in nasopharyx and nasal passages
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Contrast enhancement:
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Summary and OutcomeDestructive nasal mass invading the pterygopalatine fossa and the brain
Owners elect euthanasia
Necropsy: ◦ Severe diffuse pyogranulomatous rhinitis with multifocal bone necrosis with numerous intrahistiocytic and free fungal yeasts (Cryptococcus neoformans)
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Feline sinonasal disease
Erosive lesions of orbital lamina present◦ Unilaterally◦ 24‐75% cats with neoplasia
◦ 36% cats with non‐neoplastic dz
◦ Bilaterally◦ Only neoplastic processes
Exophthalmos present with neoplasia
Schoenborn WC, et al. Retrospective assessment of CT imaging of feline sinonasal disease in 62 cats. Vet Radiol & Ultrasound 2003Troblee TC, et al. Association between clinical, CT characteristics and histologic diagnosis for cats with sinonasaldisease. Vet Radiol & Ultrasound 2006
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Domestic Shorthair cat, 13yo, MCChronic rhinitis
Now Horner’s syndrome and swollen left eye
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T2W, fat saturation• Diffuse enhancement
of retrobulbar structures
• Muscle and fascialplane inflammation
• Left medial retropharyngeal lymphomegaly
• The tympanic bulla is fluid‐filled
.
MR appearance is most consistent with retrobulbar cellulitis and inflammation
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MRI findings T1 post contrast
Nasal cavity and frontal sinus inflammation with secondary turbinate destruction and distortion. Left otitis media and extensive left retrobulbar inflammation, with probable intracranial extension via the optic canal.
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Maine coon cat mc 12yAnisocoria, exophthalmos, nasal discharge
T2 hyperintense, contrast enhancing mass in the right retrobulbarspace, extending into the calvarium through the orbital fissure and into the retropharyngeal space
T2 T1+C
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Maine coon cat mc 12yAnisocoria, exophthalmos, nasal discharge
Bilateral otitis media, meningeal enhancement
Final diagnosis: lymphoma
T2 T1+C
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Lacrimal Duct Cyst
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Mixbreed dog 2y mc2 month history of intermittently pain on opening its mouth
Intermittent exophthalmos and reddening of eye
No abnormalities seen on radiographs of the skull
Mild muscle atrophy along the head and jaw
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Normal head post C 2 yo Mixbreed dog post C
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Pterygoid muscle
Temporal muscle
Masseter muscle
Digastric muscles
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Summary and outcome
Temporal muscle biopsy:◦ Masticatory myositis
◦ Inhomogeneous enhancement pattern results from areas of inflammation with increased vascularity and interspersed hypoattenuating areas of necrosis
Reiter AM, Schwarz T. Computed tomographic appearance of masticatory myositis in dogs: 7 cases (1999‐2006). JAVMA 2007.
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Masticatory muscle myositisAutoantibodies against masticatory muscle type 2M fibers
◦ The serum 2M antibody test is both highly sensitive (85% to 90%) and specific (100%) for diagnosis of masticatory muscle myositis
◦ Ocular signs present in 44% of patients with MMM with exophthalmos in the acute phase, and possible blindness due to stretching of the optic nerve
◦ Differential Diagnosis Extraocular myositis
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8 yo FS Golden Retriever3 month history of ocular discharge, 1 mo behavior change, painful on retropulsion OD, nonpainful when opening mouth, possible deficits in CN 5‐7
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T2W and FLAIR
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T1W AND T1C
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FindingsMRI report: Extensive right nasal‐intracranial tumor with regional bone effacement, right ocular displacement and compression of right optic neurovascular bundle, right nasofrontal obstruction with secondary sinusitis, and secondary brain edema; tumor is consistent with olfactory neuroblastomabut other etiologies are possible and biopsy will be needed for diagnosis.
Retrobulbar aspirates: carcinoma with chronic suppuration
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Communicating, fluid‐filled cavities with small areas of solid tissues, occasionally complex and multiloculated
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FLAIR T2
T1 T1 post contrast
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Myxoma/myxosarcoma‐primitive fibroblastic origin
Present for exophthalmos, third eyelid protrusion
Large breed dogs, middle aged to geriatric, retropulsion painless, fluctuant soft tissue swelling periocular tissues
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Orbital myxoma/myxosarcomaIn all five dogs, involvement of TMJ present, suggesting a resemblance to human juxta‐articular form (knee in humans)
Osteolysis present in dogs, but not humans, suggesting more aggressive behavior
Zygomatic sialocele is main ddx, with anechoic fluid filled structure◦ Uncommon, usually associated with trauma
Abscess or hematoma other differentials to consider
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Orbital fractures – ct modality of choice
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Multiplanar reconstructions
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Tooth root abscess and osteomyelitis
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CT And MRI of Optic Nerve and Intracranial DiseaseOptic nerve neuritis
Granulomatous meningoencephalitis
Optic nerve neoplasia
Cavernous sinus syndrome
Brain lesions affecting vision
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Anatomy
Optic nerve
Optic tract
Lateral geniculate nucleus
Optic radiations
Occipital cortex
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Skull foramina anatomy
II
III
IV
V opht
V max
V mand
VI
VII
VIII
IX,X,XI
XII
V
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Optic nerve imagingMRI best modality
Fat in the pterygopalatine fossa can obscure pathology – need fat suppressed sequences!
T2 T2 fat sat
T2 T2
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Schipperke fs 4yAcute Blindness
Suspect optic nerve lesion
156521
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Thickened optic nervesMeningitis
T1 +C
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Jack Russell terrier fs 7yOne week history of acute blindness and dilated pupils
208578
Optic nerve and optic chiasm thickening, regional meningitis
T1 +C
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Jack Russell terrier fs 7y
T2 hyperintense forebrain lesions
T2
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Jack Russell terrier fs 7y
Extraocular muscle and optic nerve enhancement
T1+C ‐ no fat saturation T1 +C ‐ fat saturation
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Jack Russell terrier fs 7y
T2 hyperintense forebrain lesions, optic nerve and optic chiasm thickening, regional meningitis, extraocular muscle enhancement –most consistent with granulomatous meningoencephalitis, round cell neoplasia is considered as well T1 +C
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Lymphoplasmacytic and pyogranulomatous meningitis, choroiditis and optic neuritis in a cat – FIP suspected
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Optic Cone Imaging – Need Fat Saturated Dorsal Plane Images!
2 year old German Shepherd dog, blind OS, cranial nerve deficits
T1 +C ‐ no fat saturation T2 ‐ fat saturation
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Suprasellar mass with invasion of the optic chiasm and orbital fissure
Optic cone imaging – need fat saturated dorsal plane images!
T1 +C ‐ no fat saturation
T2 ‐ fat saturation
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Mixbreed dog fs 6yComplete internal and partial external ophthalmoplegia
Mass lesion in the region of the oculomotor nerve
T1 +C T2
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Mixbreed dog fs 11yExophthalmos OS
Blind OS
No menace response OD
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Optic nerve and chiasm thickening
Meningioma of the optic nerve
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German Shepherd, fs, 7y
cranial nerve abnormalities; blepharospasms and ptosis of the right eye
mass effacing the pituitary gland and cavernous sinus.
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FindingsRelatively intensely contrast enhancing mass within the floor of the calvariumeffacing the pituitary gland and cavernous sinus. The mass is primarily on the right side but crosses midline.
A meningioma is a likely diagnosis but other differentials include histiocytic sarcoma, lymphoma and possibly a pituitary carcinoma.
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Cavernous sinusCavernous sinuses paired channels in middle fossa, drain orbit and brain, flank hypophyseal fossa & dorsum sella
Communicate w/ ophthalmic plexus through orbital fissure (rostrally) and caudally into ventral petrosal sinuses through petrooccipital foraminaCN III, IV, VI and ophthalmic branch of V course through cavernous sinus before exiting orbital fissure
Cavernous sinus syndrome:◦ CN III‐VI dysfunction—extraocular motor deficits, mydriasis, ptosis, corneal hyper‐ or analgesia, absent PLR
◦ +/‐exophthalmosTidwell AS, et al. CT and MRI of cavernous sinus enlargement in a dog with unilateral exophtalmos. Vet Radiol & Ultrasound 1997
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Weimaraner MC, 11yAcute blindness
Weimaraner Comparison dog
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Weimaraner, acute blindness
Sphenoid bone mass with compression/infiltration of the optic nerves
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Cairn terrier fs 10yelevated liver enzymes, lethargy, seizures, blindness and change in behavior
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T1 pre‐contrast images
Mass effect with displacement of neurosecretory granules (T1 hyperintense) of the pituitary gland
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T1 post contrast
Meningioma extending into sella, pituitary, cavernous sinus and optic chiasm
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Thank you!