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Centex Regenerative Therapies LLC.

A member of the

The images and information contained are the intellectual property of CRT and MiMedx they are not intended for reuse or redistribution

Christopher Francis SGM (Ret.) [email protected] 254-466-8669

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• CRT Description/Vision/ Mission • Goals• MiMedx Overview• Why Placenta Tissue/Placenta Donation Process• FDA Certification Letter• Scientific studies, Chorion Advantage, Stem Cell

Recruitment• Surgical Application• Questions

Table of Contents

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• A DV owned strategically positioned small business • CRT is committed to the advancement of military

healthcare technologies. • CRT is dedicated to providing Fort Hood world class

healthcare support.


Vision/ Mission

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• To improve medical deployability rates and Military Healthcare efficiency as well as the patient’s quality of life.

• Lower per patient healing costs • CRT will ensure Fort Hood and III Corps has

access to healing innovations which are currently available outside the gate and at the largest medical facilities in the DoD and VA health systems.

Goals

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CRT is the primary distributor of MiMedx regenerative healing products proudly

serving Fort Hood.


MiMedx Overview

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• Established in 2006 MiMedx® is the global premier processor, marketer, and distributor of human amniotic tissue.

• Over 25 clinical and scientific papers in peer reviewed journals. (clinical trials.gov)

• Over 20 patents and 80 additional patents pending. • MiMedx ®products are governed by FDA Section 361

HCT/P , 21 CFR 1271 C and D, American Association of Tissue Banks (AATB).

MiMedx Overview


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FDA Certification

“Requires FDA compliance with 21 CFR 1271 part C. DONOR ELIGIBILITY and part D. CURRENT GOOD TISSUE PRACTICE ”

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• American of Association of Tissue Bank guidelines

• Full-term planned Caesarean section donors• Blood testing (HIV, HLTV, Syph, CMV, Hep B+C)• http://www.placentadonation.com/


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• Structural Integrity• Metabolically Active• Continuous growth

without scarring• Immunologically

Privileged• Natural barrier• Both amnion and

chorion


Why Placenta Tissue

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Over 220 known regulators of inflammation and healing, including 57 growth factors, cytokines, and hormones.

Chorion Advantage

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Easy to use membrane-0r micronized for injectionsNo immune response,Reduces scar tissue,Speeds recovery

Application Methods

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Modulate Inflammation,Promote Vascularization,Reduce Scarring

Stem Cell Recruitment

https://www.youtube.com/watch?v=nwTlbEZuyt4&ebc=ANyPxKpvUoQRKtk8nNBKOhxDW0oDYsGiWtS34Zvt0m7HT1TPvHMLgw1RiG1-I509r2SpQrOTNz9bimFZXWgUrQG9oo2kdwpL8g

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• Dr Li, Dr Gurtner –Angiogenic Properties of DHACM

• Published in Vascular Cell 2014• In vitro proof of 9 specific angiogenic growth

factors and demonstrated amplification cues• Proven in vivo to progressively develop blood

vessels to the quantity of normal skin over a 28 day study from nothing to normal in 4 weeks

The Science of DHACM

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• MiMedx ® has distributed over 500,000 amniotic tissue grafts worldwide with zero reportable adverse reactions.

• Profound clinical outcomes in multiple therapeutic areas.

Amniofix


Diabetic and Chronic Wound care

https://www.youtube.com/watch?v=d179Y8kAbJ8&index=1&list=PL66DF8E2FBAD1A6D7

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• What types of procedures are performed?

• Which patients are the most challenging?

• Anastomotic leak repair

• Dehisced wounds

Where DHACM


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• Modulates Inflammation

• Acts as a natural barrier

• Enhances soft tissue healing

• Reduces scar tissue formation

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• Questions


crt.1 surgical

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