BY:MOHAMMED AFFAF US SALEEM

RIMS ADILABAD

CROHN’S DISEASE IS A CHRONIC,RELAPSING

AND REMITTING DISEASE THAT INVOLVES

TRANSMURAL INFLAMMATION OF THE INTESTINE.

USUALLY CONFINED TO DISTAL SMALL INTESTINE AND COLON.

THE DISEASE REFLECTS A FAILURE TO DOWN-

REGULATE INFLAMMATORY RESPONSES TO

NORMAL COMMENSAL MICROBIOTA.

IN GENETICALLY SUSCEPTIBLE INDIVIDUALS, MUTATIONS IN GENES

CONTROLLING INNATE IMMUNE RESPONSE

REGULATORS OF ACQUIRED IMMUNITY APPEARS TO PREDISPOSE TO

DISEASE WHEN INDIVIDUALS ARE EXPOSED TO APPROPRIATEENVIRONMENTAL FACTORS,

The pattern recognition receptors(PRRs)

May be intracellular, such as the NOD

protein

One of the NOD protein the NOD-2

encoding gene may undergo mutation

which leads to crohn’s disease

NOD -2 protein

The mainstay of treatment remains high-dose corticosteroids to suppress

inflammation nonspecifically.

Surgery may be required to treat strictures,

fistulas and abscesses.

Probiotics therapeutic microorganisms can

be used to maintain healthy microbiota

The cascade is selectively implicated in

individuals patients with different genetic

backgrounds .

probiotics

corticosteroids

The end