critical care in obstetrics oaa november 2015 · critical care in obstetrics oaa november 2015...
TRANSCRIPT
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Critical care in obstetricsOAA November 2015
Andre VercueilConsultant in critical care and obstetric
anaesthesiaKing’s College London
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Critical care in obstetrics
• The scale of the problem• Definitions and Confidential enquiries• MBRRACE-UK - causes of maternal death and
morbidity• Who needs intensive care?• Why women need it• How to deliver ICU care
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Millenium development goals
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MMR < 20/100 000 live births… BUT
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Data is difficult to find… most recent comparators up to 2004
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Deaths and MMR 2003/4 U.K MMR @ 7.7/100 000 BIRTHS higher than average
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We have a problem… large discrepancies
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And we know even less about ICU admission…
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What is obstetric critical care -definitions
•Severe morbidity due to any cause related to or aggravated by pregnancy or its management but not due to accidental or incidental causes regardless of the site or duration of the pregnancy, up to 42 days from delivery
• Paruk F, Moodley J. Severe obstetric morbidity. Curr Opin Obstet Gynecol 2001;13(6):563–8.
•A woman who nearly died but survived a complication that occurred during pregnancy, childbirth or within 42 days of termination of pregnancy
– Cecatti JG, Souza JP, Oliveira Neto AF, et al. Pre validation of the WHO organ dysfunction based criteria for identification of maternal near miss. Reprod Health 2011;8:22.
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What proportion of women with severe morbidity receive critical care?
1. > 75%
2. > 66%
3. > 50%
4. >33%
5. None of the above
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Surrogates for severe obstetric morbidity
• ITU admission– Related to workload – the busier the less likely
• Zwart et al
– ‘HDU’ in up to 50%• Zeeman et al
– Only ~ one third of women with severe morbidity receive ITU treatment (Scotland, Netherlands)
• Worse in developing countries• ICU admission unlikely to be comparable across settings
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ICU admission ICU transfer most common in Asia
Haemorrhage and hypertensive disordersmost common reason in Europe
Best Practice & Research Clinical Obstetrics and Gynaecology 27 (2013) 789
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Clinical criteria for severe morbidity
Europe has low death to morbidity ratio –Few deaths, significant morbidity
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Confidential enquiries
• Since 1952 in U.K– ‘Gold standard’– Three yearly until 2014, now annually
• MBRRACE-UK: Mothers and Babies: Reducing Risk through Audits and Confidential Enquiries across the UK
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90 per 100,000maternities
1952-54
Maternal Mortality in the UK
11 per 100,000maternities
2006-08
2009-12
10 per 100,000maternities
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Maternal death rate 2003-12(Three year rolling averages)
0
2
4
6
8
10
12
14
16
2004 2005 2006 2007 2008 2009 2010 2011
Rate
per
100
000
mat
erni
ties
Mid-year of each three-year period
27% reduction in maternal death rate, p<0.001
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Maternal death rate 2003-12(Three year rolling averages)
0
2
4
6
8
10
12
14
16
2004 2005 2006 2007 2008 2009 2010 2011
Rate
per
100
000
mat
erni
ties
Mid-year of each three-year period
Direct and Indirect maternal death rate
Direct maternal death rate
Indirect maternal death rate
48% reduction in direct maternal death rate, p<0.001No significant decrease in indirect maternal deaths, p=0.73
Is this from improved haemorrhage and eclampsia management?
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Maternal mortality in The Netherlands, France, the UK and Ireland
Sources: Dutch Maternal Mortality Committee 2014, MBRRACE-UK 2014,CNEMM 2013, MDE 2014
0
1
2
3
4
5
6
7
8
Netherlands 2009-12 France 2007-09 UK 2010-12 Ireland 2010-12
Direct
Indirect
Rate
per
100
,000
Why is there this difference?
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Causes of maternal death
DIRECT:HaemorrhageThrombosisPre-eclampsiaSepsisAFE
INDIRECT:Heart diseaseSuicideInfluenzaSepsis StrokeCancerDiabetes
Sepsis is increasingly important…
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Causes of direct maternal death• Thrombosis and thromboembolism is now the
leading cause of direct maternal death
• Significant decrease in the maternal mortality rate from pre-eclampsia and eclampsia – now the lowest ever rate – 0.38 per 100,000 maternities
• The mortality rate from genital tract sepsis has more than halved between 2006-8 and 2010-12;– a statistically significant decrease – RR 0.44; 95% CI 0.22-0.87, p=0.016
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Causes of indirect maternal death
• Major contribution from influenza and other non-genital tract sepsis deaths
• Overall rate of maternal mortality from infectious causes in 2009-12 was 2.0 per 100,000 maternities (95%CI 1.6-2.6)
• Cardiac disease remains the largest single cause of indirect maternal deaths; rate more than doubled since 1985-87 (RR 2.2, 95%CI 1.4-3.6)
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Why are so few women with indirect causes admitted, when this is what people die from?
11.4% pregnant or recently pregnant80% post-partumNon-obstetric pathology in 20%
Up to 5% of deliveries require level 2 care
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This is an obstetric emergency… is it managed as one?20% septic shock, though few deaths.
365 cases, 4.7/10 000 maternities (729 674 BIRTHS IN 2012)
For each sepsis death, 50 women have life-threatening morbidity…
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78% REQUIRE ICU ADMISSION…
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Causative organism according to septic shock diagnosis
0
5
10
15
20
25
30
35
40
45
50
E.coli Group Astrep
Group Bstrep
Other strep Staph Mixed Other Unknown No Labconfirmedinfection
Prop
ortio
n of
wom
en (%
)
Septic shock No shock
Acosta CD, Kurinczuk JJ, Lucas DN, Tuffnell DJ, et al. (2014) Severe Maternal Sepsis in the UK, 2011–2012: A National Case-Control Study. PLoS Med 11(7): e1001672. doi:10.1371/journal.pmed.1001672
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Time course SIRS to sepsis
• Fast! – 245 (83%) severe sepsis <24hrs– 49 (85%) septic shock <24hrs
• Group A Strep– 16 (50%) < 2hrs– 24 (75%) < 9hrs– most common cause of post-partum maternal death
worldwide– Postpartum women have 20x increased incidence of
Group A Strep disease compared to non-pregnant women
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Risk factors for severe sepsis
• A priori– BAME – we see this in Sweden as well – Primip – Pre-existing medical condition– Febrile illness/antibiotics in previous 2 weeks
• Postpartum sepsis– Operative vaginal delivery (even though almost all
receive prophylactic antibiotics)– Caesarian section (before or after labour)
PROM was not significant…
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Absolute risk (95% CI) of all sepsis and severe sepsis/septic shock as a function of the number
of a priori risk factors.
Acosta CD, Knight M, Lee HC, Kurinczuk JJ, et al. (2013) The Continuum of Maternal Sepsis Severity: Incidence and Risk Factors in a Population-Based Cohort Study. PLoS ONE 8(7): e67175. doi:10.1371/journal.pone.0067175
We should worry, knowing who our patients are…
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• 83 women died from sepsis between 2009 and 2012– 20 deaths from genital tract sepsis– 63 deaths from other infections
• 36 due to influenza• 27 due to other infections
• 12 of the deaths were late deaths (>42 days)
Summary of Deaths from Sepsis
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Mortality Rates from Genital Tract Sepsis: 1985 - 2011
Significant decrease in mortality rate from genital tract sepsis from 1.13 maternal deaths per 100,000 maternities in 2006-8 to 0.50 per 100,000
in 2010-12
0.00
0.20
0.40
0.60
0.80
1.00
1.20
1.40
1.60
1.80
1985-87 1988-90 1991-93 1994-96 1997-99 2000-02 2003-05 2006-08 2009-11
Rate
per
100
,000
mat
erni
ties
Triennium
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Genital Tract Sepsis: Delays in Management
• Delay in identification of the source of infection• When recognised as genital tract – not fully investigated or
monitored • Over-reliance on antibiotics to control the infection at
source• Poor recourse to imaging & repeated imaging – MRI / CT
scan• Reluctance to take surgical measures - appropriate
drainage of collections or surgical excision of infected tissue
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Other causes of sepsis
• H1N1• Between 2009 to 2012, 36 pregnant women died from influenza (comprising 43%
all deaths from infection)• Of these,
• 27 had confirmed H1N1• 5 had probable H1N1 • 1 had Influenza A (not confirmed if H1N1 variant)• 3 had Influenza B
• Pneumococcal disease• 9 women died
• Five from pneumococcal meningitis • One from a pneumococcal brain abscess.• One from pneumococcal pneumonia and invasive pneumococcal
infection • Two from pneumonia of unclear cause
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Was that data (though we didn’t have it) a wake-up call?
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Recommendations for midwifery practice as set out in Chapter 13 of ‘Saving Mothers’ Lives’
Recognise and act on symptoms suggestive of serious illness, including sepsis, as outlined in the ‘Back to Basics’ chapter of the full Report.Provide pregnant women and new mothers with information about the prevention and signs and symptoms of possible genital tract sepsis and the need to seek advice early if concerned, as well as the importance of good personal hygiene. Assess risk adequately throughout the continuum, re-assessing as needed if circumstances change.Refer and escalate concerns to a medical colleague of appropriate seniority.Make early referral to psychiatric services of women with serious mental health problems.Ensure the availability and use of interpreting services.Provide continuity of care for vulnerable women.Carry out, record and act on basic observations for both low and high risk women.
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Interfaces of care are crucial in this patient group!
Much will depend on local geography…
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How many UK obstetric units offer dedicated ‘obstetric HDU’?
1. < 33%
2. < 50%
3. < 66%
4. <75%
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Of those, who can manage invasive monitoring?
1. < 33%
2. <50%
3. <66%
4. <75%
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Staff in 87% of obstetric units not able to look after central or arterial lines…
Only 40% able to offer dedicated obstetric ‘HDU’
• Training requirements VERY SIGNIFICANT…
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• S
• Sepsis now leading direct cause of death
• Indirect causes on the increase– Older population– Co-morbidities– Medical conditions previously incompatible with
pregnancy– Social deprivation and immigration
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CEMD – “unacceptable levels of suboptimal care…”
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Comparison between women who died and women who survived
Classification of care received
Percentage of women who died
Percentage of women who survived
Good care 23% 26%
Improvements to care which would have made no difference to outcome
14% 53%
Improvements to care which may have made a difference to outcome
63% 21%
Incredibly concerning….
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£££…
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So does this carry the correct prescription for improvement?
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26 pages of them….
Multiple handovers…
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Important given what MBRRACE tells us…
Senior decision-making!
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Deciding if this mother need intensive care? The King’s 7 T’s
• Type (of problem)• Timing (relative to baby coming out, onset of
illness, hospital admission)• Tempo (how rapidly is the pathophysiology
developing)• Trajectory (where are thinks likely to be in say 1
hour, 6 hours)• Triage (physiological and operational)• Trial (& error)- need frequent review• Treatment responsiveness-need frequent review
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Should this mother be admitted
• Yes… if you are considering it– Especially if indirect!
• End of the bed assessment by experienced obstetrician, anaesthetist or intensivist as good as any predictive model– Standard ICU systems not calibrated for this group
• Move the patient before they get too sick
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Themes• Delay in diagnosis• Incomplete assessment• Immediate management• Antibiotics• Lactate• Fluid management• Assessment & deterioration• Care setting• Communication• Governance
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How do I get her there?
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Are critically ill obstetric patients special?
• Not really…• Still need basic principle of intensive care
– Early antibiotics– Imaging and source control
• Still need to avoid iatrogenic injury• Still need to apply evidence based
supportive care (sedation holds; CVC care; safe ventilation)
• But...
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General characteristics of critically ill mothers
• Generally high extra-vascular fluid• Worth measuring pulmonary pressures and
examining right ventricular function. • Circulatory characteristics are difficult, especially if
pre-eclampsia is present - can be dynamic.
• Coagulopathy- poorly understood dynamic condition and probably need near-patient testing.– In general pro-coagulant, whatever the INR or platelet
count.– Need discussion with obstetric team - balance of risk
between haemorrhage and VTE.
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Management
• Remember the 7 T’s for decision making and management
• Remember the key bits of transfer that maximise safety
• Is obstetric critical illness different- yes and no• Talk to your ICU. Plan ahead. Joint M&M. Rotate
midwives through the ICU• And...rotate the ICU nurses through your obstetric
HDU (they do actually enjoy it)• MDT simulation including transport and angiographic
interventions• ICU doctors like being on labour ward
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Summary
• Scale of obstetric near-misses is uncertain• Direct vs indirect causes of mortality differ across
Europe– ICU admission primarily for direct (haemorrhage and
eclampsia)• Sepsis is an increasing problem in both groups• Early diagnosis and treatment with senior review
essential• Difficult (in the U.K) to adequately manage this
outside of ICU– There is plenty of work for all!
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Challenges for the future
• Obesity, maternal age and co-morbidity
• Intensivists increasingly physician-trained
• CCMDS and CCG’s (£££)
• CQC scrutiny
• Maintaining skills– On labour ward– Within ITU