critical care coma, seizures. coma neurologist's favorite consultation history, straightforward...
TRANSCRIPT
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Critical Care
Coma, Seizures
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Coma
Neurologist's favorite consultation History, straightforward Neurologic examination, focused Differential diagnosis, limited
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Neurologic examination + battery of tests Initial stabilization → specific causative
condition → Tx Recognition of reversible causes of coma
BAO, nonconvulsive status epilepticus, and herniation
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Classification of Levels of Consciousness 3 A’s of consciousness
awake ( fully roused and thus not asleep ) alert ( able to pay attention ) aware ( understanding of oneself )
3 A’s = alert Awake and alert = demeted Awake = dilirious -3 A’s = coma Excellent and easily reproducible way of assessing
level of consciousness
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Unresponsive Patient
Fully conscious but is unable or unwilling to respond verbally (Aphasia)
Waxing-and-waning level of wakefulness (dilirium)
Comatose
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Initial Stabilization
Stabilize the patient by addressing the ABCs of resuscitation
Endotracheal intubation (neuro xm b4 intubation)
Avoid D5W
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Clinical Evaluation
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Focused Neurologic Examination
Reasons for neurologic examination coma patient Glasgow Coma Scale (GCS) yield important diagnostic information
Complete and exhaustive neurologic examination is totally unnecessary
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Focused Neurologic Examination
Spontaneous movements (~ 15 seconds) Papillary response (~ 15 seconds) Ocular motility (~ 15 seconds), and Motor response (~ 15 seconds)
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Spontaneous movements should be observed Generalized seizures
Tonic (sustained contractions with upper-extremity flexion and lower-extremity extension)
Tonic-clonic movements (tonic contractures alternating with periods of muscle atonia, resulting in rhythmic contractions)
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Pupillary responses distinguishes structural from metabolic coma
Pupils are generally resistant to metabolic insult
Indicate the integrity of the brain stem
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Minimal or absent eye movement in conjunction with reactive pupils also typically signifies a metabolic process
Gaze deviation may indicate a stroke: Cortical stroke will cause the eyes to look
toward the damaged side of the brain
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Whereas a pontine stroke will cause the eyes to look away from the damaged side of the pons
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Vertical disconjugation of the eyes (skew deviation) is indicative of brain stem disease and frequently occurs during basilar artery thrombosis
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General Physical Examination
Blood pressure, heart rate, and cardiac rhythm are key to the diagnosis of the various cardiovascular and hemodynamic causes of coma
Hypothermia is noted in cases of exposure, drowning, methanol poisoning, and septic shock
Hyperthermia is obviously suggestive of an ongoing infectious process
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Rise in intracranial pressure (ICP) occurs with any space-occupying lesion
Signs of rising ICP include increasing blood pressure decreasing heart rate slowing or periodic respiration (Cushing
phenomenon)
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General Measures, Triage, and Test Battery Serum electrolyte, calcium, magnesium,
phosphorus, blood urea nitrogen (BUN), and creatinine levels, as well as liver function tests
A complete blood count (CBC), a urinalysis, and a urine toxicity screen should also be obtained
Lumbar puncture should be performed only if meningitis
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Coma cocktail consisting of dextrose naloxone thiamine—is administered if the cause of
coma is not immediately apparent from the brief history and physical examination
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Administering dextrose to a thiamine-depleted patient may precipitate the Wernicke-Korsakoff syndrome.
As a rule, therefore, thiamine should always be given before dextrose.
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When drug overdose or toxin ingestion is suspected, activated charcoal, 50 to 100 mg (with or without gastric lavage), should be given to prevent systemic absorption.
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Management of Specific Causes of Coma
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Basilar Artery Occlusion
Uncommon cause of stroke Caused by embolism Intrinsic atherothrombosis Frequently presents with a stepwise
accumulation of neurologic deficits that culminates in a coma.
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Comatose patient with BAO usually manifests obvious clinical signs of brain stem injury, such as quadriparesis, skew deviation, and diminished gag reflex
Management of BAO should be aimed at immediate recanalization of the occluded artery
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Thrombolysis, either intravenous (with tissue plasminogen activator) or intra-arterial (with urokinase or mechanical clot disruption), may be lifesaving
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Seizures
Cause coma in two different ways coma may be the initial manifestation of the
immediate postictal state after a generalized seizure
coma may develop when multiple generalized seizures occur in succession and there is not enough time between seizures to allow patients to recover
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Tonic-clonic seizure begins with a tonic contraction that lasts as
long as 30 seconds, followed by several minutes of repeated muscle contractions, loss of pupillary response to light, sweating, tachycardia, excessive bronchial secretion, and marked hypertension
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Aim is not to stop the body from convulsing but to stop the abnormal cerebral electrical activity immediately
Lorazepam Goal of therapy is to achieve a burst-
suppression pattern on electroencephalography for 12 to 24 hours before any attempt is made to taper medications
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Increased Intracranial Pressure
Head of the patient's bed should be elevated to an angle of 30° to 45° to facilitate venous return from the head
Hyperventilation Mannitol, 0.25 mg/kg every 4 to 6 hours
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Metabolic Derangements
Intoxication overdose of alcohol, narcotics, sedatives, or
some combination induce depression of respiration and
cardiovascular function
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Hypoglycemic coma plasma glucose levels fall below 45 mg/dl jitteriness with palpitations diaphoresis focal neurologic symptoms mimicking
ischemic stroke to frank coma Most common cause is diabetes; other
common causes include alcoholism, hepatic failure, and renal failure.
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Urgent restoration of the patient to a euglycemic state
Ampule (50 ml) of a 50% solution
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Diabetic ketotic coma Key components of the management of
diabetic ketoacidosis Replacement of fluid losses (the average fluid
loss is approximately 7 L). Normalization of electrolyte levels and careful
monitoring of serum potassium. Restoration of acid-base balance (bicarbonate
infusion is reserved for severe cases).
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Correction of insulin deficiency (4 to 6 U/hr). Replenishment of energy stores (e.g., through
dextrose infusion with insulin coverage until the patient can resume oral feeding).
Investigation to identify an underlying cause (infection is common