crispr patent landscape - ipstudies · eu horizon2020 expert on innovation in smes 2013-2015 •...
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![Page 1: CRISPR PATENT LANDSCAPE - IPStudies · EU Horizon2020 expert on Innovation in SMEs 2013-2015 • ICT Technology Expert for various licensing facilitators and aggregators in France,](https://reader035.vdocuments.us/reader035/viewer/2022062923/5f0b01267e708231d42e61f0/html5/thumbnails/1.jpg)
CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-2017 IPStudies SARL
CRISPRPATENTLANDSCAPEAugust2017
Intangibleassets deserve closer scrutiny
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CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-2017
Copyright
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CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-2017
Ourteam
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CorinneLEBUHAN,PhDICTExpertIPStrategy&Management
• FundedIPStudiesin2010tohelpSwiss&EUhigh-techSMEsdevelopandexecutetheirIPvaluationplansusingthelatestpatentanalyticstoolsandtrends
• 15yearsexperienceinIPstrategyandmanagement– formerVPKnowledgeManagementofNagravision-Kudelski Group,inchargewithpatents(200families),standards,R&Dcollaborations,licensingandtechnicalpublicationsportfolios
• TeachesinternationallicensingpracticesandIPstrategyatIEEPI–EUHorizon2020expertonInnovationinSMEs2013-2015
• ICTTechnologyExpertforvariouslicensingfacilitatorsandaggregatorsinFrance,GermanyandtheUS
• Universitypostgraduateinmanagementofinnovationandintellectualproperty(UniversityofStrasbourg,2008),PhDinCommunicationsScience(EPFL,1998),MsC inElectricalEngineering(INSARennes,1994)
• ExperiencedwithPatbase,EPO/RegisterPlus,USPTO/PAIR
• InternationalnetworkofIPpractitionersandlicensingmanagers-MemberLES,IEEE,AROPI,AAIEEPI
FabienPALAZZOLI,PhDLifeSciencesExpertPatentAnalysis&Landscapes
• JoinedIPStudies in2013todeveloptheIPanalyticsofferinginlifesciences&biotechnology
• 9+yearsexperienceintechnologytransfers,patentmapping/landscapingandFTO-drivenresearchintelligencefortheFrenchpublicsectorandbiotechSMEs- formerIPanalyticssalesmanagerforFISTSA,theCNRStechnologytransferoffice
• Author/co-authorof18scientificandtechnicalpublications/communications,aswellasonebookchapter
• Lifesciencespatentanalystforvariousbiotech/medtech SMEsinSwitzerlandandinEurope
• PhDinLifeSciences(Exploitationofpatentinformationinapublicresearchlaboratory:identificationoftechnologicalnichesinbioproduction andgenetherapy,UniversityofTours,2011),MsC inBiotechnologyandLaw(UniversityofTours,2007)
• ExperiencedwithOrbit,Patbase,Intellixir,patentofficesdatabases
• Internationalnetworkofpatentinformationanalysts
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CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-2017
Tableofcontents
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• Methodology
• OveralltrendsoftheCRISPRpatentdatabase• Temporaldistributionofpatentfilings(2002-2017)• Temporaldistributionofpatentfilingsbytypeofplayers(2002-2017)• Worldmapofpriorityfilings• Temporaldistributionofpriorityfilings(2002-2017)• Worldmapofpatentextensions• Mainpatentapplicants/assigneesandtemporaldistributionoftheirfilings• Co-filingsbetweenapplicants/assignees
• BreakdownoftheCRISPRpatentdatabase• BreakdownbyClaimcoverageofpatentfamilies
• Breakdownofthepatentportfolio• Temporaldistributionoffilings• Positioningofapplicants/assignees
• BreakdownbyComponents• Breakdownofthepatentportfolio• Temporaldistributionoffilings• Positioningoftheapplicants/assignees
• BreakdownbyChimericproteins• Breakdownofthepatentportfolio• Temporaldistributionoffilings• Positioningofapplicants/assignees
• Mainforwardcitedpatentfamilies• Appendice1– Licensingannouncements• Appendice2– Affiliationmappingofplayerspresentinthepatentlandscape
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CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-20175
Temporaldistributionofpatentfilingsbytypeofplayers(2002-2017)
Ø 1043 filings by institutional applicants/assignees (60.5%),Ø 553 filings by industrial applicants/assignees (32.1%),Ø 74 filings by individual inventors (4.3%),Ø 57 co-filings between industrial applicants/assignees and institutional applicants/assignees (3.3%).Ø The years 2016 and 2017 are not complete due to the delay of publication of 18 months.
1724patentfamilies
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CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-20176
Mainpatentapplicants/assignees (≥12patentfamilies)
Institutional applicant/assignee
Industrial applicant/assignee
Ø Affiliates & subsidiaries have been gathered under their parent company (Danisco with DuPont…). Co-filings arecounted for each co-owner: a patent application co-filed between the MIT, the Harvard University and theBroad Institute is counted once for each of this applicant.
Ø The patent portfolio of DuPont comprises historical patent families on CRISPR sequences dealing with the typingof bacterial strains, cultures with improved phage resistance and applications for preparing food.
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CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-2017
Temporaldistributionoffilingsofmainapplicants/assignees(≥12patentfamilies)
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CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-2017
Co-filingsbetweenapplicants/assignees(≥2co-filings)
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Number ofpatentfamiliesintheportfolio
Co-filing(s)betweenthetwo applicants
Ø The co-filing map shows the co-filings between applicants/assignees. The same type of link can be found whenan assignment occurred between two players, giving the historical applicants as well as the new owners.
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CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-20179
BreakdownoftheCRISPRpatentdatabase(1)
Ø A patent family can be classified in several categories (e.g. ‘Genome Editing’ and ‘Therapeutic application’and ‘Human cell-subject’ and ‘CRISPR-Cas system’…).
• Genomeediting
• Transcriptional-epigeneticregulation
• Otherapplication
• Therapeutics-Diagnostics
• Bioproduction
• Drugscreening
• Modifiedcell
• Modifiedanimal
• Modifiedplant
Applications
• Humancell-subjet
• Mammaliancell-organism
• Otheranimalcell-organism
• Plantcell-organism
• Fungi-algae-yeast
• Eukaryoticcell-organism
• Prokaryoticcell
• Otherorganism
• Undefinedcell-organism
Cells/Organisms
• Nuclease
• ZFNuclease-ZFP
• Meganuclease
• TALENuclease-TALEP
• gRNA-guidesequence
• Cas-CRISPRenzyme
• CRISPRsystem
• Otherchimericprotein
• Vector-Delivery
• CRISPRsequence
‘Moleculartools’
‘CLAIMCOVERAGE’
The1724patentfamilies havebeenmanually classified
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CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-201710
BreakdownoftheCRISPRpatentdatabase(2)
Ø A patent family can be classified in several categories (e.g. ‘Genome Editing’ and ‘Therapeutic application’and ‘Human cell-subject’ and ‘CRISPR-Cas system’…).
COMPONENTS CHIMERICPROTEINS
Chimericnucleases
• Undefinednucleases
• ZFNucleases
• Meganucleases
• TALENucleases
• RNA-GuidedNucleases
• Otherchimericnucleases
Otherchimericproteins
The1724patentfamilies havebeenmanually classified
• Cas-CRISPRenzyme
• MutatedCas - nickase
• dCas
• Cas9
• mutatedCas9- nickase
• dCas9
• OtherCas
• OthermutatedCas
• Cpf1-mutatedCpf1
• gRNA
• sgRNA-chiRNA
• crRNA
• tracrRNA
• Nuclease-Nickase
• Meganuclease
• Integrase
• Recombinase
• Repressor-Activator
• Acetyltransferase
• Deacetylase
• Methyltransferase
• Demethylase
• Kinase
• Othercatalyticdomain
• Undefinedcatalyticdomain
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CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-2017
BreakdownbyClaimcoverageofpatentfamiliesBreakdownofthepatentportfolio
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Applications Cell /Organism ‘Covered molecular tools’
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CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-2017
BreakdownbyClaimcoverageofpatentfamiliesPositioningofmainapplicants/assignees(≥12patentfamilies)
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CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-2017
BreakdownbyComponentsBreakdownofthepatentportfolio
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CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-2017
BreakdownbyComponentsPositioningofmainapplicants/assignees(≥12patentfamilies)
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CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-2017
BreakdownbyChimericproteinsBreakdownofthepatentportfolio
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Nucleases including chimeric nucleases Other chimeric proteins
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CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-2017
BreakdownbyChimericproteinsPositioningofmainapplicants/assignees(≥12patentfamilies)
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CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-201717
Licenseannouncements(samplepage4)
Licensor Scope Licensee Date
Toolgen
Worldwidelicense&sublicensesrightsforresearchapplicationsincludingthedevelopmentandsaleofreagents,celllines,andanimalmodels,aswellasrightsforhighthroughputscreening,diagnostics,andbioproduction.ToolGen retainsitsrightsinbroadareasincludinghighthroughputscreening,diagnostics,bioproduction,plantbiotechnologyandgene/celltherapy.
ThermoFisher Scientific 2015/03
VilniusUniversityExclusiverights tothe Cas9-mediatedgenomeeditingintellectualpropertyownedbyVilniusUniversityforallcommercialuses,includinginagriculture.
DuPont 2015/06
UniversityofMinnesota
Exclusiveworldwiderights toanAAVgenetherapyandintellectualpropertyfromtheUniversityofMinnesotatotreatpatientswithFanconianemia(FA)disorderandotherrareblooddiseasesusingtheCRISPR/cas9technology platform.
AbeonaTherapeuticsInc 2015/06
CaribouBiosciencesDupont(incl.VilniusUniversity)
Multi-faceted agreementincludes thecross-licensing ofkeyIP,aresearch collaboration,andfinancial investments byDuPont inCariboutodevelopandutilizeCRISPR-Castechnologyforproductdevelopmentinmultiplefieldsincludinghumanandanimaltherapeutics,diagnostics,industrialbiotechnology,researchtools,andcertainagriculturesegments.TheDuPontlicensetoCaribouincludesrightstotheCas9-mediatedgenomeediting IPownedbyVilniusUniversityandexclusivelylicensedtoDuPont inmultiplefields and exclusiveaccess intheresearch tools field.
CaribouBiosciencesDuPont(incl.VilniusUniversity)
2015/10
CrisprTherapeutics
$105millionupfront—$75millionincash,$30millionequityinvestment- futuredevelopment,regulatoryandsalesmilestonesofupto$420millionforeachofuptosixCRISPR-Cas9-basedtreatmentsforwhichVertexhasagreedtolicenseexclusivedevelopmentrights (incl.cystic fibrosis).Royaltiesonfuturesales.
Vertex 2015/10
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CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-2017
Furtheranalyticsforyourspecificneedswiththeonlinedatabase
• Zoomonpatentportfoliosofspecificapplicants
• Zoomonpatentsfiledinacountry/region(US,EP,CN…),withinatimeperiod
• Zoomonpatentscoveringanapplication,adedicatedtechnology,aspecificationorafunctionalsubset
• Linktoonlinepatentofficeregisterstoreviewlatestlegalstatus
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CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-2017
Accesstotheinteractive“navigate,zoom,clickandshowpatent”database
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CRISPR Patent Landscape – SAMPLE – August 2017 ©2014-2017
Order
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This is only a sample report with partial data. Our fulloffer includes:• ananalysisofthepatentlandscape,covering1724patentfamilies,worldwide• asynthesisofIPstrategyfindings,tovisualizekeytrendsintermsofpatentapplicants,collaborationnetworks,competitortechnologypositioning,keyinventorsandR&Dwhitespacesoutofthelandscape• anon-lineaccesstothe1724patentfamiliesset,soyoucanvisualize,navigate,focusandextractthemostrelevantpatentdataaccordingtoyourspecificneeds.
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