1. Crestor TabletsCrestor Tablets (Rosuvastatin calcium) is a syntheticlipid-lowering agent used in combination with exercise,diet, and weight-loss to treat high cholesterol andrelated conditions. It is also indicated for risk reductionof MI, stroke, and arterial revascularization proceduresin patients without clinically evident CHD, but withmultiple risk factors. The Swiss Pharmacy, Geneva Switzerland

2. Crestor TabletsActive IngredientThe active pharmaceutical ingredientcontained in Crestor Tablets isRosuvastatin calcium. The Swiss Pharmacy, Geneva Switzerland 3. Crestor TabletsChemical Structure The Swiss Pharmacy, Geneva Switzerland 4. Crestor TabletsIndicationsCrestor Tablets (Rosuvastatin calcium) are used as anaddition to diet when the response to diet and exerciseis inadequate.Prevention of Major Cardiovascular events:In adult patients without documented history ofcardiovascular or cerebrovascular events, but with atleast two conventional risk factors for cardiovasculardisease, Crestor Tablets (Rosuvastatin calcium) areused to:Reduce the risk of nonfatal myocardial infarctionReduce the risk of nonfatal strokeReduce the risk of coronary artery revascularisation The Swiss Pharmacy, Geneva Switzerland 5. Crestor TabletsIndicationsHypercholesterolaemia:Reduce elevated LDL-C, totalcholesterol, triglycerides and toincrease HDL cholesterol in patientswith primary hypercholesterolaemia(heterozygous familial and nonfamilial) and mixed dyslipidaemia. The Swiss Pharmacy, Geneva Switzerland 6. Crestor TabletsRecommended DosageCrestor Tablets may be given at any time of theday, with or without food. The dosage of Crestorfor various indications is given below:Prevention Of Major Cardiovascular Events:A dose of 20 mg once daily has been found toreduce the risk of major cardiovascular events.Hypercholesterolaemia:The usual dose range is 10 - 40 mg orally once aday. The dosage of Crestor should beindividualised according to the goal of therapyand patient response. The majority of patients arecontrolled at the start dose. The Swiss Pharmacy, Geneva Switzerland 7. Crestor TabletsRecommended DosagePrimary hypercholesterolaemia, mixeddyslipidaemia and isolatedhypertriglyceridaemia:The usual start dose is 10 mg once a day. Forpatients with severe hypercholesterolaemia, astart dose of 20 mg may be considered.Homozygous familialhypercholesterolaemia:For patients with homozygous familialhypercholesterolaemia a start dose of 20 mgonce a day is recommended. The Swiss Pharmacy, Geneva Switzerland 8. Crestor TabletsContraindicationsCrestor Tablets are contraindicated inpatients with the following conditions:Hypersensitivity to Rosuvastatin calcium, orany inactive component of this medication.In pregnant women, while breast-feeding and inwomen of child-bearing potential not usingappropriate contraceptive measures.In patients with active liver disease orpersistent, unexplained elevations intransaminases.In patients with pre-disposing factors formyopathy/rhabdomyolysis. The Swiss Pharmacy, Geneva Switzerland 9. Crestor TabletsSide Effects of Crestor Tablets(Rosuvastatin calcium)The most frequent side effects includeHeadache, myalgia, asthenia, constipation,dizziness, nausea, abdominal pain. Theuncommon side effects include Pruritus, rashand urticaria.Rare side effects include Myopathy (includingmyositis), hypersensitivity reactions (includingangioedema), rhabdomyolysis, pancreatitis. The Swiss Pharmacy, Geneva Switzerland 10. Crestor TabletsWarnings And PrecautionsLiver: Liver function tests should be performedbefore initiation of treatment and periodicallythereafter.Skeletal Muscle: As with other HMG-CoA reductaseinhibitors, effects on skeletal muscle eg.uncomplicated myalgia, myopathy and, rarely,rhabdomyolysis, have been reported in patientstreated with rosuvastatinRace: Pharmacokinetic studies show an increase inexposure in Asian subjects compared withCaucasians The Swiss Pharmacy, Geneva Switzerland 11. Crestor TabletsWarnings And PrecautionsDiabetes Mellitus: There is sufficient evidence to supportan association between statin use and new onset type 2diabetes mellitus; however the risk appears to be mainly inpatients already at increased risk of developing type 2diabetes. Risk factors for the development of type 2diabetes include raised fasting blood glucose, history ofhypertension, raised triglycerides and raised body massindex.Interstitial Lung Disease: Exceptional cases of interstitiallung disease have been reported with some statins,especially with long term therapy. Presenting features caninclude dyspnoea, non-productive cough and deteriorationin general health (fatigue, weight loss and fever). The Swiss Pharmacy, Geneva Switzerland 12. Crestor TabletsWarnings And PrecautionsChildren And Adolescents 10 To 17 Years Of Age: Theevaluation of linear growth (height), weight, BMI (bodymass index), and secondary characteristics of sexualmaturation by Tanner staging in paediatric patients takingCrestor is limited to a one year periodEffect On Ability To Drive And UseMachines:Pharmacology testing revealed no evidence of asedative effect of crestor. From the safety profile, Crestoris not expected to adversely affect the ability to drive oruse machines.Pregnancy And Lactation: The safety of Crestor Tablets(Rosuvastatin calcium) during pregnancy and whilst breastfeeding has not been established. Women of child-bearingpotential should use appropriate contraceptive measures. The Swiss Pharmacy, Geneva Switzerland 13. Crestor TabletsOverdose TreatmentThere is no specific treatment in theevent of overdose of Crestor Tablets(Rosuvastatin calcium). In the event ofoverdose, the patient should be treatedsymptomatically and supportivemeasures instituted as required.Haemodialysis is unlikely to be ofbenefit. The Swiss Pharmacy, Geneva Switzerland 14. Crestor TabletsCrestor Tablets manufactured byAstra Zeneca UKFor more information click here The Swiss Pharmacy, Geneva Switzerland