We attended the 10th National Conference for

Clinical Research 2016 (NCCR). The objectives of this conference were to (1) discover the usage of ‘Big Data’ – its impact and challenges in research and healthcare, (2) examine its potential and discover the profound benefits to patient and population, (3) consider the enhancement to clinical outcomes and healthcare and (4) present health economics and use of Big Data. Twenty speakers from Malaysia, USA, United Kingdom, Singapore, Australia, Korea and Taiwan were invited to communicate their passion and struggles to inspire the new generation. This year, more than 500 participants from all over the world attended this conference. This conference was held on 27th and 28th July 2016 at Hotel Istana, Kuala Lumpur. Apart of the lectures, the highlight of the conference was the research award competition consisting of Oral and poster presentation. Two of our CRC staff, Yang

Su Lan (pharmacist) and Lilyiana Pengui (CRC Admin Manager) were selected to participate in the poster presentation. (Futher details on big Data will be discuss in next page: continuing medical learning section).

N a t i o n a l c o n f e r e n c e o f

c l i n i c a l r e s e a r c h 2 0 1 6

I N S I D E T H I S

I S S U E :

Highlights 1

Tuesday CME

Study Design 2

Big Data Forum 2

National EQ-5D sym-

posiums 3

Research update 4

Upcoming Workshops 4

H O S P I T A L Q U E E N E L I Z A B E T H I I

CRC Newsletter PAGE 1 Issue 3,JULY-AUGUST 2016

Lilyiana presenting her poster to QEH2 hospital director

CRC HQE2 group photos

(from left) Su Lan, Siow Yen, Dr Yen, Dr Hj Razak, Dr Liew HB (from left) Dr Yen, Dr Hj Razak, Dr Khairie, Su Lan, Lilyiana, Siow Yen, Wong KK, Izzati

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Continuing medical education (Tuesday CME Corner)

21st century is an information era. We are surrounded by data and information. In the healthcare industry, with the constant influx of information, healthcare professionals are constantly inundated by heaps data, also known as big data. All this data collected but unable to be fully utilized, to pro-vide meaningful value to guide clinician or decision-makers or policymaker. Other than policymaking and guidance to clinician decision, big data can also help the researchers to speed up the process of their research. Thus, the theme for this year’s Malaysia National conference for Clinical Re-search (NCCR), “Big Data Driving Clinical Research for health”.

What is Big data?

Big data is a term that describe the large volume of

data both structured, semi –structured and unstructured. It often means `dirty data' and the fraction of data inaccu-racies increases with data volume growth." It can be characterized by 3Vs (Volume, Variety, Velocity)- the ex-treme volume of data, must be processed to become mean-ingful information.

Ministry of Health, Malaysia plan on big data

Ministry of Health Malaysia collaborates with health informatics center to create a system for Malaysia Health Data Warehouse (MyHDU). The intention is to col-

Adopted from Introduction to Genetic Epidemiology - Lesson 4: Analytic Study Designs

www.pitt.edu/~super7/33011-34001/33681.ppt

Big data driving clinical research: National Conference of Clinical Research 2016

Reference: NCCR 2016 Big data Driving clinical research for health NCCR speakers’ Abstract (page 26) http://arvensystech.com/img/prd3.jpg

lect all data at every visits in all healthcare facilities and for future linkages. All healthcare facilities include all facil-ities belonging to Ministry of Health, Ministry of Educa-tion, Minisitry of Defense and Private Hospital. The cover-age of visits data will include wellness and screening. Within the clinical coverage there will be registries, drugs, medication, procedure and clinical support activities like physiotherapy.

Computer science and “Big data” will be the transformation of healthcare system. In Malaysia, we need more talents to support and invest in this area, to make “dirty data” meaningful for policymaker and clini-cian in order to facilitate decision making.

Definition: A study design is a specific plan or protocol for conducting study which allows the investigator to translate the

conceptual hypothesis into a operational.

Type of study design:

Different between cross-section, cohort, case con-trol. Time is the key element for this 3 study design.

Written by, Dr. Yen CH, Sulan HQE ll CRC

Study Design

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N a t i o n a l e q - 5 d

s y m p o s i u m

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In conjunction with the launching of EQ-5D validation

project, the EQMYS committee organized the first na-

tional EQ-5D symposium in Penang. The objective of the

symposium was to introduce and sensitize Malaysian

healthcare professionals on the use of EQ5D question-

naire. EQ-5D is a standardised instrument to measure

quality of life as health outcome. Unlike the disease-

specific scoring instrument, EQ5D result is comparable

across multiple diseases and able to facilitate the deci-

sion making. EQ5D is particularly useful in cost-utility

analysis (CUA) and recently NICE has enforced the sub-

mission of CUA data prior to approval of new drug subsi-

dy.

EQ5D has been validated in more than 100 lan-

guages in various countries and questionnaire is availa-

ble freely for academic use. This questionnaire is user-

friendly, hassle-free and time-saving. There is also an

EQ5D-youth version where the questionnaire is aimed

for paediatric subjects. Besides introducing the develop-

ment and application EQ5D, this symposium also had a

panel discussion on the challenges of bringing cost-utility

analysis into healthcare decision-making in Malaysia.

This workshop was a collaboration of National CRC and

Clindata. This workshop covers extensively on the follow-

ing topics:

-Study design

-Randomization design and process

-Sample size determination

-Case report form design

-Essential elements of protocol (to follow the interna-

tional standard)

Learning aside, this workshop serves as a networking

platform. CRC Staff from different states came

(experienced and new) to exchange ideas and experiences

with each other. We learnt that each CRC has their own

interesting researches and there might be a chance of

collaboration in future for a national research.

I n t r o d u c t i o n o f

c l i n i c a l T r i a l

Written by, Sulan (HQE ll CRC pharmacist )

Picture Adopted from http://pharmatips.doyouknow.in/images/2012.10/

Introduction-Of-Clinical-Research-Clinical-Trial-011046437520983.png

Adopted from https://s-media-cache-ak0.pinimg.com/564x/03/

f1/76/03f17613c0d367d52e560ed3a697aba0.jpg

Comic Conner:

Adopted from https://s3.amazonaws.com/lowres.cartoonstock.com/

education-teaching-education-educator-teachers-students-learning-

mbcn610_low.jpg

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RESEARCH CONSULTATION CLINIC

This Research Consultation Clinic is aim to assist re-searchers in:

1. Literature review search

2. NMRR registration

3. Protocol development

4. Protocol review

and many more.

Please do not hesitate to contact us for more infor-mation.

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Research Update

NO ISR STUDY

1 RELAX ASIA 1 ODYSSEY

2 COMMANDER 2 FOURIER

3 LIMUS-DCB 3 DEB

4 ASIAN-HF 4 QUALIFY

5 DES ISAR 5 MIRAGE

6 STENTYS 6 REDUCE

7 VICTORIA 7 MASCOT

8 SPIRE ADIA 8 VERIFY NOW

9 ACOSYM

COMING ISR

1.Pan Asia burden study

2.Pre DM with CVD

IIR STUDY

1 BIA of fibrinolytic therapy

2 Heart failure cost analysis

3 Heart failure self care behaviour

4 TOE audit

5 HF Ramadhan

6 CRHD

7 BIA of platelet function test

IIR MONTHLY UPDATE:

Factors associated with self-care behaviors among heart

failure patients

This is single centre, cross-sectional study designed to assess the

factors associated with heart failure self care behaviors among pa-

tients in Queen Elizabeth Hospital ll and to evaluate the association

between self care behaviors and sociodemographic variables, psy-

chosocial variables and heart failure knowledge.

Study started 1st February 2016

Recruit target 160

Recruitment until 31st August 2016 99 (61%)

UPCOMING WORKSHOPS

Budget Impact Analysis 22—23th October 2016 (Saturday & Sunday)

Scientific Writing Workshop 5—6th November 2016 (Saturday & Sunday)

Research Camp 19-20th November 2016 (Saturday & Sunday)

Introduction to clinical audit

28-29th November 2016 (Monday & Tuesday)

Please visit our website e CRC for more details.

Please scan here to register our workshop and

booking research consultation clinic

Contact: Tel: 088—324 600 (ext 2019) Email: rcc.crchqe2@gmail.com SCAN ME