craig e. taplin, md division of endocrinology and … a fitness program improve hba1c? ... training...
TRANSCRIPT
![Page 1: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/1.jpg)
Craig E. Taplin, MDDivision of Endocrinology and Diabetes
Seattle Children’s Hospital
![Page 2: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/2.jpg)
1. Review some basic assumptions about exercising with T1DM
2. How much should those with T1DM exercise, and are those guidelines being followed?
3. How does T1DM affect physical fitness?4. How does physical activity affect HbA1c?5. How does physical activity affect cardiovascular
risk factors in T1DM?6. Why does exercise cause high and low blood
sugars?7. How can that be prevented/treated?
![Page 3: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/3.jpg)
Exercise is good for T1DM◦ It’s fun!
◦ Improves cardiovascular health
◦ Weight control
◦ Help maintain healthy blood pressure
◦ Improves cholesterol profile
◦ Good way to handle stress
◦ It is often outside - vitamin D
![Page 4: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/4.jpg)
“… participate daily in 60 minutes or more of moderate to vigorous physical activity…”
![Page 5: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/5.jpg)
Same effect on blood sugar???
![Page 6: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/6.jpg)
![Page 7: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/7.jpg)
So, youth with type 1 diabetes exercise at least as much as their non-diabetic peers.
This is a huge success story in and of itself!
But… Is physical fitness affected by T1DM in children? And does T1DM affect physical fitness?
What does recent data tell us?
![Page 8: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/8.jpg)
Copyright restrictions may apply.
Herbst, A. et al. Arch Pediatr Adolesc Med 2006;160:573-577.
Is exercise associated with HbA1c in youth?
1-2 x week>2 x week
19,143 patients
![Page 9: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/9.jpg)
2012 UK study - 60 young people with T1DM, mean age 12.5 years, mean HbA1c 8.4% and 37 controls (siblings)
•no difference in fitness at baseline•no difference in degree of physical activity
Moderate–vigorous physical activity(but not fitness) predicted1/3 of the variance in HbA1c, even when accounting for confounding variables such as insulin dose, age, weight, puberty stage…
![Page 10: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/10.jpg)
What about the other way around…
◦ What is the effect of type 1 diabetes on fitness and exercise performance?
![Page 11: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/11.jpg)
“Eurofit physical fitness test”◦ Nine tests- motor and cardiorespiratory fitness tests (VO2
max estimated by shuttle run test)**
◦ Performed by PE teachers
◦ Between 8am and 10am
◦ BGL had to be between 90-180 mg/dL** not validated as a measure in T1DM
![Page 12: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/12.jpg)
106 youth with T1DM, 130 controls◦ Mean HbA1c 8.2-8.9% (depending on group)
T1DM group just as active as the controls
Decreased fitness (VO2 max) in girls and pubertal boys with T1DM c/w controls
![Page 13: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/13.jpg)
In those without diabetes:◦ ↑age, skinfold thickness, ↓physical activity and female sex
were all associated with ↓VO2 max
In those with diabetes◦ All of the above, plus ↑HbA1c associated with ↓VO2 max
What about the other way around?
In multiple regression, VO2 max was the only predictor of ↓ HbA1c.
![Page 14: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/14.jpg)
Adult (trained) athletes
◦ A1c <7% were as fit or fitter than those without T1DM
◦ A1c>7% less fit
![Page 15: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/15.jpg)
High blood sugars
Decreased physical fitness
??
![Page 16: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/16.jpg)
Or…
This is not at all clear, as most data is cross-sectional
![Page 17: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/17.jpg)
Perhaps we should consider cardiovascular health as well as HbA1c when considering the data on physical activity and exercise?
What does that data tell us?
![Page 18: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/18.jpg)
Influence of Physical Activity on Vascular Health
![Page 19: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/19.jpg)
![Page 20: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/20.jpg)
Diabetes, Obesity and MetabolismVolume 13, Issue 4, pages 382-384, 23 FEB 2011 DOI: 10.1111/j.1463-1326.2011.01361.xhttp://onlinelibrary.wiley.com/doi/10.1111/j.1463-1326.2011.01361.x/full#f1
![Page 21: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/21.jpg)
Adult (trained) athletes
◦ A1c <7% no cardiac dysfunction c/w controls
◦ A1c>7% decreased cardiac function
![Page 22: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/22.jpg)
Diabetes Care, October 2012
Mean HbA1c 8.7%T1DM for 6 years
![Page 23: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/23.jpg)
What else might be going on to explain these findings?
Nadeau K et al, JCEM 2010
![Page 24: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/24.jpg)
Insulin resistance predicted exercise performance in T1DMNadeau K et al, JCEM 2010
Fit
ter
Insulin sensitivity
![Page 25: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/25.jpg)
Children with T1DM exercise as much as their non-diabetic counterparts
◦ this is a huge success story in and of itself
The data is mixed on whether children with T1DM have overall reduced fitness-and it may be time spent exercising as much as absolute fitness that matters
The higher the HbA1c, the poorer the physical fitness (does not prove causality)
We do not have good data on acute performance and glycemia
Does a fitness program improve HbA1c?
◦ The jury is out but in cross sectional studies fitness, or activity, predicts HbA1c
Children with T1DM who are less active have an adverse cardiovascular profile◦ … but those who are active may not
Training can improve fitness in T1DM and vascular health
Children with T1DM appear to be insulin resistant – this may be a critical link to pursue
![Page 26: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/26.jpg)
![Page 27: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/27.jpg)
“I think the worst thing imaginable is to get really low and pass out”
Jay Cutler, NFL quarterback
Denver Broncos, Chicago Bears
![Page 28: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/28.jpg)
![Page 29: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/29.jpg)
Resistance versus Aerobic
High Intensity vs low intensity
Early vs Late effects
![Page 30: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/30.jpg)
12 adults, mean HbA1c 7.1%
45 minutes of weight lifting or 45 minutes of cardio on treadmill
Diabetes Care 2013;36:537-542
Higher sugars during and
immediately after resistance
exercise
![Page 31: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/31.jpg)
Maximal session, or Intense Intervals, induce more of:◦ Adrenaline◦ Noradrenaline◦ Growth Hormone◦ Cortisol
This has been shown to be preserved in people with T1D
Together, these hormones cause glucose to rise (or stay the same) by increasing glucose output from liver, and making the body resistant to insulin◦ The effect is short lived, though…
![Page 32: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/32.jpg)
![Page 33: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/33.jpg)
Diabetes Care 2013, Davey et al
So:1. Aerobic exercise at submaximal effort causes a slow and
steady drop in blood sugar2. Intense exercise such as all out efforts, or intervals, or
resistance (weights) doesn’t have the same effect, and may raise blood sugar acutely
3. But there is still a risk later on of a low blood sugar (overnight)
![Page 34: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/34.jpg)
![Page 35: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/35.jpg)
Frequent specific factor in etiology of severe hypoglycemia is exercise, particularly aerobic exercise◦ Bhatia, Wolfsdorf Pediatrics 1991 – exercise caused 71% of episodes◦ Davis, Jones et al, Diabetes Care 1997 – 75% of events occurred at night
and most were related to increased activitiy
Fear of hypoglycemia is significant barrier to exercise in T1DM.◦ Diab Care 2008 2109-9, Ped Diab 2007 362-8
*** The unifying management goal in T1DM is the lowest possible HbA1c for that individual patient WITHOUT excessive hypoglycemia
![Page 36: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/36.jpg)
For 130 lb. person; 15 grams of CHO every…
Cycling: 15 minutesSoccer: 10 minutesBasketball: 10 minutesRunning: 10 minutesWalking: 30 minutes
To maintain a steady blood glucose…
ISPAD Guidelines
![Page 37: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/37.jpg)
Diabetes Care. 2006 Oct;29(10):2200-4.
![Page 38: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/38.jpg)
75
100
125
150
175
200
2 PM 4 PM 6 PM 8 PM 10 PM 12 AM 2 AM 4 AM 6 AM
Me
an
Glu
co
se
(m
g/d
L)
Sedentary day
Exercise day
Overnight glucose levels after
afternoon exercise
Exercise Period
4:00 – 5:15 PMmean BGL 154
28% had lows
mean BGL 131
48% had lows
Impact of exercise on overnight glycemic control in children with type 1 diabetes mellitus. J Pediatr. 2005 Oct;147(4):528-34.
![Page 39: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/39.jpg)
Midday Exercise in Adolescents – higher risk for low sugars for the next 11 hours
45 minutes cycling at 95% lactate threshold starting at noon
11pm
![Page 40: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/40.jpg)
20 grams of glucose more was needed for the hour of exercise, and 2-3 grams more per hour up until 11 hours later
Midday bought of exercise – 45 minutes at 95% lactate threshold
![Page 41: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/41.jpg)
Remember the duration of action of rapid acting insulin – 3 to 4 hours
Try and minimize peaking boluses during exercise◦ Peak is at 90 minutes
Eat early enough so you can bolus to help fill energy stores
Eating within 2 hours of exercise may require a bolus reduction, and/or basal reduction
Eating afterward may require a bolus reduction
![Page 42: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/42.jpg)
Adjusting post-exercise meal bolus- how much?
Diabetes Care 2013 Campbell et al
Full bolus
50% bolus
75% bolus
![Page 43: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/43.jpg)
“Hypo” unawareness is common in children
Antecedent exercise and antecedent hypoglycemia are known risk factors (Cryer, Diab Care 2008)
![Page 44: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/44.jpg)
Hypoglycemia on nights following exercise:
◦ peripheral glucose utilization is increased by exercise
◦ counterregulatory hormone responses are impaired by sleep
◦ insulin concentrations are unchanged because of the treatment regimen (but could be)
Tamborlane W, JCEM 2007
![Page 45: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/45.jpg)
1. Address the increased insulin sensitivity Reduce the insulin (easier with pumps)
2. Address the autonomic failure to counterregulate Give medications that ↑ glucose
3. Eat more food/snacks? perhaps counterproductive (weight)
increased glucose requirement occurs later in the night
not very effective in adult studies
![Page 46: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/46.jpg)
Overnight Blood Glucose Measurements
150
175
200
225
250
275
300
21:00
22:30
23:30
0:30
1:30
2:30
3:30
4:30
5:30
Time
Blo
od
Glu
co
se (
mg
/dl)
'
Terbutaline
Basal Reduction
Control
![Page 47: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/47.jpg)
For some, ceasing the pump during exercise may be sufficient to prevent a nocturnal event
An overnight basal rate reduction◦ physiologically logical, sensible and safe◦ Some high sugars undesirable
![Page 48: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/48.jpg)
What to recommend for those not on a pump?
Predictive alarms and closed loop systems?
![Page 49: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/49.jpg)
![Page 50: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/50.jpg)
Diagrammatic representation of clinical study procedures.
Sherr J L et al. Dia Care 2013;36:2909-2914
Copyright © 2011 American Diabetes Association, Inc.
![Page 51: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/51.jpg)
Episodes of overnight treatable hypoglycemia (reference blood glucose <60 mg/dL) during
OL and CL.
Sherr J L et al. Dia Care 2013;36:2909-2914
Copyright © 2011 American Diabetes Association, Inc.
![Page 52: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/52.jpg)
A: Overnight insulin delivery in units/h 7–11 h postexercise (10:00 p.m. to 2:00 a.m.), with CL
associated with lower insulin delivery (P = 0.008).
Sherr J L et al. Dia Care 2013;36:2909-2914
Copyright © 2011 American Diabetes Association, Inc.
![Page 53: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/53.jpg)
Different Kinds of Exercise do Different Things to Blood Sugars acutely◦ But all increase risk of lows many hours later
Consider pump suspension during exercise as one option to prevent lows (and/or basal rate reduction beforehand)◦ But beware of highs if this is done with intense or interval exercise!
Consider minimizing the amount of rapid acting insulin on board during exercise and then snack to maintain sugar level
Beware of hormonal responses (excitement/nerves) that might quickly wane (highs followed by lows)
Consider decreasing the post-meal bolus, and also night time insulin to prevent night time low blood sugars (this is what the artificial pancreas seems to do
Check blood glucose often – this is the best management strategy of all!
![Page 54: Craig E. Taplin, MD Division of Endocrinology and … a fitness program improve HbA1c? ... Training can improve fitness in T1DM and vascular health ... Jay Cutler, NFL quarterback](https://reader031.vdocuments.us/reader031/viewer/2022030418/5aa4b58c7f8b9a517d8c43f5/html5/thumbnails/54.jpg)
“If only exercise for children with diabetes could just be child’s play”
Editorial, Journal of Pediatrics, Nov 2010 (Laffel L)
Thank you.