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John S. Rumsfeld, MD PhD FACC Chief Science Officer & Chief Innovation Officer, American College of Cardiology Professor of Medicine, University of Colorado School of Medicine COVID-19 and Beyond ACC and Clinical Research

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Page 1: COVID-19 and Beyond/media/Non-Clinical/Files-PDFs-Excel-MS-Word-etc/2020/05/27/...May 27, 2020 · CV Care in COVID era. Delays in / avoidance of CV care. COVID-19 treatments / RCTs

John S. Rumsfeld, MD PhD FACCChief Science Officer & Chief Innovation Officer, American College of Cardiology

Professor of Medicine, University of Colorado School of Medicine

COVID-19 and BeyondACC and Clinical Research

2020

March April May

RAASMyocardial damageHQC / Long QTPPEProning teams

2020

March

April May

ThrombosisKawasaki-like syndromeCV Care in COVID eraDelays in / avoidance of CV careCOVID-19 treatments / RCTsRe-opening

Page 6: COVID-19 and Beyond/media/Non-Clinical/Files-PDFs-Excel-MS-Word-etc/2020/05/27/...May 27, 2020 · CV Care in COVID era. Delays in / avoidance of CV care. COVID-19 treatments / RCTs

2020

March April May

>150 trials launched

Page 9: COVID-19 and Beyond/media/Non-Clinical/Files-PDFs-Excel-MS-Word-etc/2020/05/27/...May 27, 2020 · CV Care in COVID era. Delays in / avoidance of CV care. COVID-19 treatments / RCTs

multinational registry671 hospitals; 6 continents96,032 COVID-19 patients

risk of mortalityrisk of ventricular arrythmias

Page 10: COVID-19 and Beyond/media/Non-Clinical/Files-PDFs-Excel-MS-Word-etc/2020/05/27/...May 27, 2020 · CV Care in COVID era. Delays in / avoidance of CV care. COVID-19 treatments / RCTs

Page 11: COVID-19 and Beyond/media/Non-Clinical/Files-PDFs-Excel-MS-Word-etc/2020/05/27/...May 27, 2020 · CV Care in COVID era. Delays in / avoidance of CV care. COVID-19 treatments / RCTs

Page 12: COVID-19 and Beyond/media/Non-Clinical/Files-PDFs-Excel-MS-Word-etc/2020/05/27/...May 27, 2020 · CV Care in COVID era. Delays in / avoidance of CV care. COVID-19 treatments / RCTs

Page 13: COVID-19 and Beyond/media/Non-Clinical/Files-PDFs-Excel-MS-Word-etc/2020/05/27/...May 27, 2020 · CV Care in COVID era. Delays in / avoidance of CV care. COVID-19 treatments / RCTs

Has COVID-19 changed the way you think about clinical evidence?

What are the largest challenges and opportunities for clinical research?

What are the key questions we should should be addressing?

How can ACC lead?

Test in 2by2 tables, RCTs, and power - pku.edu.cn

P173857 CV COVID - SEP · Web viewThe Cabo Verde COVID-19 Preparedness and Response Project STAKEHOLDER ENGAGEMENT PLAN (SEP) Introduction/Project Description The Cabo Verde Covid-19

Efficacy of statins in primary and secondary prevention of CV events - well established Meta-analyses of RCTs : - demonstrated dramatic reductions in

Introduction to Study Design and RCTs Simon Thornley

COVID-19 AND THE CV SERVICE LINE –Part 5€¦ · • 501(c)(3) with

The COVID-19 and Cardiovascular Nexus · 2020-04-13 · COVID-19 and Cardiovascular Disease • Patients with CV disease are very susceptible • CV Disease pts have more severe illness

Criteria for Assessing The Feasibility of RCTs. RCTs in Social Science: York September 2006 Today’s Headlines: “Drugs education is not working” “ having

RCTs - Hydrocephalus 2000 / Sydney Randomized Controlled Trials

Biostatistics in cancer RCTs

Cardiovascular Trials Over 2 Decades: Progress on Pragmatism? · –598 CV RCTs, 3 major journals (1986-2015); increased from 21% in 1986-1990 to 33% in 2011-2015 –RCTs supporting

Randomised controlled trials (RCTs)

Analyzing RCTs

Implementing RCTs: What Agency Administrators Need to Know

9 e rcts of metals & metal cmpds (boardworks)

Avoiding bias in RCTs

CV 215 thuc hiên quyêt liệt phòng chống dịch Covid-19

COVID-19 · 4/14/2020 · • $2.2 million Community Development Block Grant COVID-19 (CDBG-CV) • $1.1 million Emergency Solutions Grant COVID-19 (ESG-CV) • GR Business Assistance

Criteria for Assessing The Feasibility of RCTs

P173857 CV COVID - SEPdocuments.worldbank.org/...Engagement-Plan-SEP-Cabo..… · Web viewThe Cabo Verde COVID-19 Preparedness and Response Project . STAKEHOLDER ENGAGEMENT PLAN

RCTs references

U COVID‑19 omparativ y ot SARS‑CV‑2, SARS SARS ......SARS‑CV‑2, SARS SARS‑ oronaviruses RajanishjGiri1k j·kTaniyajBhardwaj 1j·kMeenakshijShegane1j·kBhuvaneshwarijR.jGehi1j·kPrateekjKumar1j·k

MDG-Relevant J-PAL RCTs Review

Revised 2 Manuscript Interventions for PwD Final · observation by clinicians and carers were eligible. If the review included both RCTs and non-RCTs, the pooled effect size for RCTs

Introduction to Study Design and RCTs

Energy change during chemical rcts

Drug-Eluting Stents in AMI (RCTs)

Statistical Analysis of Composite Endpoints in …hbiostat.org/papers/RCTs/multEndpoints/luMao/ASASC5.pdfEndpoint: All-cause mortality or CV hospitalization (time to first event) Results

Microcredit RCTs in Development: Miracle or Mirage? Health

Dental Implants in Edentulism - ams.edu.sg 1+ Well conducted meta-analyses, systematic reviews of RCTs, or RCTs with a low risk of bias 1-Meta-analyses, systematic reviews of RCTs,

Causality, RCTs and Impact Evaluations · Et cetera. Peter van der Windt Causality, RCTs and Impact Evaluations. Causal Inference and RCTs Measurement Practical Things The Fundamental

Nimble RCTs - World Bankpubdocs.worldbank.org/en/.../Nimble-RCTs...v4.pdf · Nimble RCTs A Powerful ... Colombia. Active users ... Content Combining reminders with lottery incentive

A Presentation for Pos of Rcts

CDBG-CV (COVID EMERGENCY FUNDING) · 2020-05-01 · CDBG-CV (COVID EMERGENCY FUNDING) Applications Due: Wednesday, May 20, 2020 . 2020 Subrecipient Funding Application 2 President

RCTs: Lessons from ECMO

OptimalityofMatched-PairDesignsinRandomizedControlledTrialsAbstract Thispaperstudiestheoptimalityofmatched-pairdesignsinrandomizedcontrolledtrials(RCTs).Matched-pairdesignsareexamplesofstratiﬁedrandomization