“corneal cxl for the treatment of non- responding infectious keratitis ” cristian a. cartes, md...
TRANSCRIPT
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“Corneal CXL for the Treatment of Non-Responding Infectious Keratitis ”Cristian A. Cartes, MD ; Miguel Srur, MD; Leonidas Traipe, MD
Fundación Oftalmológica los Andes, Santiago, Chile.
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The authors have no financial
interest in the subject matter of
this research
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Purpose
To report the use of corneal collagen crosslinking in the treatment of infective keratitis not responding to antimicrobial therapy.
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Methods
Retrospective, case series of patients with infectious keratitis unresponsive to antimicrobial therapy. Patients were treated by instilling riboflavin 0.1% solution for 10 minutes to saturate the cornea, followed by exposure to UVA light for 20 minutes. The primary outcome was the time to resolution of the epithelial defect.
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Results
• Eleven patients (13 eyes) were
included.
• After riboflavin and UV collagen
crosslinking therapy, there was a
rapid decrease of pain.
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Results
Patient EyeGende
rVA pre
VA post
Epithelization
Melting
Emergency PKP
1 R f light light 172 no no
2 L f 0.05 0.05 Neurotrophic ulcer no no3 L f light light 142 no no4 R f cf 0.03 21 no no5 R f n.a no yes yes
L f n.a no yes yes6 L m cf cf 112 no no7 R m hm hm 22 no no8 R m 0.05 0.1 3 no no
9 L f hm cf Neurotrophic ulcer no no10 R f hm hm 45 no no
L f cf cf 82 no no11 L m n.a no yes yes
Hm: hand motion, cf: counting fingers, n.a.: not availabe
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Results
38%
23%
8%
31%
Etiology
Protozoal Bacterial Fungal Unknown
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Conclusion
• This serie suggests the positive effects of
riboflavin and UV collagen crosslinking on
infectious keratitis unresponsive to antimicrobial
therapy.
• We think this treatment should be considered in
refractive keratitis.
• Randomized studies are needed to further
evaluate efficacy.
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“Corneal CXL for the Treatment of Non-Responding Infectious Keratitis ”Cristian A. Cartes, MD (Presenting Author); Miguel Srur, MD; Leonidas
Traipe, MD
Fundación Oftalmológica los Andes, Santiago, Chile.
Mail to: [email protected]