cord blood banking: ambiguous policy

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Panorama Wednesday, November 5, 2014 DECCAN HERALD 11 Copper may help prevent Ebola spread. P12 » Benefits of sanitation immense, but task ahead is tough By Naresh Kapoor P rime Minister Narendra Modi’s Swachh Bharat campaign is a well- thought out move. It needs to be im- plemented seriously. Human excreta are the potential source of transmitting many infectious diseases such as cholera, ty- phoid, infectious hepatitis, polio, cryp- tosporidiosis, and ascariasis. Ensuring that people have access to safe drinking water is another critical dimension of sanitation. Unsafe water, poor sanitation and hy- giene leads to under nutrition, pneumonia, worm infestations, reduced physical growth, weakened physical fitness and impaired cog- nitive function, particularly for children un- der the age of five. Heavy metals, toxic or- ganic and inorganic substances also can pose serious threats to human health and environment, particularly when industrial wastes are added to the waste stream. Therefore, benefits of sanitation are im- mense, but the task ahead is not so easy! The PM has given the countrymen a task to be achieved in a holistic manner. Sani- tation is not only about maintaining clean- liness around human habitats. If looked at in totality, sanitation is all about ensuring a healthy environment to all living crea- tures, which can come by self-realisation and awareness on good health. A survey conducted by the National Sample Survey Office (NSSO), Union Ministry of Statistics and Programme Implementation between July 2012 and December 2012 had made some startling observations, which were based on the findings covering 4,475 vil- lages in rural areas and 3,522 urban blocks spread over all states and Union Territo- ries. About 88.5 per cent households in ru- ral India had improved source of drinking water while the corresponding figure was 95.3 per cent in urban India. Among rural households, 85.8 per cent had sufficient drinking water and for urban India the cor- responding figure was 89.6 per cent. This means that making available safe drinking water to Indian masses is not a difficult task. It just needs one major push, which will bring the whole populace within the ambit of pure and safe drinking water supply chain. It will also tremendously help animal husbandry as well. By providing safe drinking water, we will only save our people suffering from water borne dis- eases. To have pure source of water, overall sanitation needs to be improved upon. What about latrines? The survey shows that 59.4 per cent and 8.8 per cent house- holds in rural and urban India, respectively, had no latrine facilities. It needs to be ad- dressed on a priority basis. A healthy India needs toilet facilities for all. About 38.8 and 89.6 per cent households in rural and ur- ban India, respectively, had access to ‘im- proved’ type of latrine. Providing airy accommodation is anoth- er important dimension of sanitation goals. If we force a large populace to live in com- pressed accommodation, then most of them will end up picking up many ailments. We will never have healthy children from these areas. It is a major problem in urban India, where a chunk of people are con- strained to live in slums against all odds and health hazards. If one goes by the sur- vey, then only 26.3 and 47.1 per cent house- holds in rural India and urban India, re- spectively, had dwelling units with ‘good ventilation.’ As much as 31.7 per cent of ru- ral households and 82.5 per cent of urban households had ‘improved drainage’facility in the environment of their dwelling units. It is not that people do not want to move out of slums or squatter settlements, but they need to be provided with opportuni- ties to do so. At all India level, 70.8 per cent of households had cited ‘better ac- commodation’ as the main reason for which they thought to move out of slum or squatter settlement whereas 11.7 per cent households had identified ‘proximity to place of work’ as the main reason. Best practice models There is a need to spread awareness on sanitation related issues and opting for the ‘best practice’ models. We must under- stand that sanitation is a cross-cutting issue and has implications for a variety of devel- opment areas. To attain the target of total sanitation, we need to work as well-knit unit. Total sanitation has to go beyond just toilets. Urban women use sanitary napkins but in rural areas, women use a piece cloth and have no private space to dry the piece of cloth in sun. It is used while still wet. This has health and hygiene implications. Sanitation has also a strong connection with human dignity and well-being, public health, nutrition and even education. Which is why Mahatma Gandhi once said: “Sanitation is more important than inde- pendence.”Sanitation issues should be giv- en priority in our development policy ap- proaches. Its implications need deep study and greater understanding. The role of community leadership in changing old habits and ways of thinking will be crucial as our own experience has shown. Simi- larly, sanitation has to be located in an in- tegrated framework of public health policy to ensure that sanitation activities are in- deed adequately funded. For example, hand washing with soap can reduce the in- cidence of acute respiratory infections (ARI’s) by around 23 per cent according to the World Health Organisation. There is also a need to develop sanitation technologies for diverse eco-systems. New technologies have to be affordable and sus- tainable. Traditional water systems had been engineered in our villages to optimise scarce resources including the use of water. We must use scientific ingenuity to take In- dia to the next generation of sanitation tech- nologies. Human waste should be treated as a resource to be recycled. With more ur- banisation and industrialisation, this chal- lenge will gain importance. We have to strive for sanitation for dignity and health. Good sanitation should be a birthright of every citizen of India. Total health will only come through total sanitation. (The writer is Director, BLK Super Special- ity Hospital, New Delhi) By Jad Mouawad S pace travel has long been the preserve of governments and sci-fi fans, but in recent years a crop of new commercial ventures, often backed by billionaire entrepreneurs, has sought to get into the race. The list of so-called thrillonaires has only grown, along with their ambitions: Jeff Bezos, the Amazon founder who set up Blue Origin to lower the cost of space technology; Elon Musk, who founded SpaceX with the aim of going to Mars one day; and Richard Branson, who start- ed the space tourism company Virgin Galactic. But two recent accidents involving commer- cial rockets have underscored the high risks and soaring costs involved in any spaceflight. Last Friday, a Virgin Galactic space plane exploded during a test flight over the Mojave Desert, killing one pilot and injuring another. Days earlier, an Orbital Sciences rocket carrying a supply vessel to the International Space Sta- tion blew up seconds after it was launched. Both accidents are under investigation. Al- though they were unrelated, their occurrence just days apart was a stark reminder that the path to space is just as arduous for private com- panies as it is for government-funded pro- grammes. “The engineering and physics of space tend to be unforgiving, no matter who is doing this,” said Scott Pace, director of the Space Policy In- stitute at George Washington University and a former assistant administrator at the National Aeronautics and Space Administration. The common thread between these new space initiatives is that they all are looking for ways to sharply cut the cost of spaceflight. With- out that, analysts say, there is no realistic prospect of making spaceflights both routine and affordable in the future. “What you are seeing playing out are differ- ent experiments, by different groups, trying different approaches,” Pace said. “To me, this does not call into question the basic logic of re- lying more on the private sector.” The push to privatise spaceflight is in part borne of necessity. After pioneering space exploration and landing on the moon with programmes like Mercury, Gemini and Apollo, NASA has had to adapt to tighter budgets and redefine its mission. Today, one of its main goals is to encourage and fund the development of commercial space entities. Lori B. Garver, a former deputy administra- tor at NASA and one of the most prominent advocates for commercial space during her tenure, said that public funds should focus on activities that advance technology and provide public benefits to all, like planetary science. At the same time, she said, the government should encourage private companies to move ahead and find innovative ways of reducing costs. “In my view, the private sector has the same incentive, or even more, to get things right as the government does,” Garver said. “If we only trusted risky things to the government, we would only fly in government-owned and oper- ated airplanes.” Many of the current commercial operations have some form of government support. Orbital Sciences is operating under a $1.9 billion con- tract from NASA to deliver cargo to the space station. Its Antares rocket exploded on the third of eight resupply missions. The same is true of SpaceX, which was re- cently awarded $2.4 billion by NASA to build a transportation system for astronauts within the next three years. SpaceX was also the recipient of an earlier $1.4 billion contract to deliver cargo to the space station. Boeing also won a NASA contract for $4.6 billion to build a spacecraft ca- pable of flying astronauts to the space station. SpaceX and Orbital Sciences have sought to reduce costs in different ways. Orbital’s rockets use a pair of refurbished engines built in the Soviet Union in the 1960s and 1970s. The en- gines were intended for Soviet rockets destined for the moon, but were never used and lay in storage for decades. The engines were refur- bished by an American company and incorpo- rated into the Antares rocket by Orbital. SpaceX, by contrast, builds its engines for its Falcon 9 rocket and aims to reduce costs, in the long term, by reusing the rocket. The com- pany has succeeded in firing a test rocket called Grasshopper, having it hover at around 2,400 feet and then returning it to its point of launch. But its efforts to land Falcon 9 rockets have so far been unsuccessful, though the company says it is getting closer. In August, a bigger test rocket trying a high-altitude test was destroyed shortly after takeoff. No one was injured. NASA is “looking for cheaper access to space,” said Marco A. Caceres, a space analyst at the Teal Group, a consulting firm in Virginia. The trouble is that reliability and price are often tied together. “It may be unreasonable to expect to pay under a certain amount to get a reliable vehicle,”Caceres said. “That comes at a cost.” To the edge of space Virgin Galactic is an exception to the model of government-funded launchers. The company has been working on an experimental vessel to take paying passengers to the edge of space and back. The craft, called SpaceShipTwo, was de- signed to be launched from a plane, then rocket up to its apogee at about 62 miles, an altitude considered the boundary of outer space. At the top of its ascent, two tail booms would rotate upward into a so-called feathered position in- tended to create more drag and stability, and allow the plane to descend gently back into the atmosphere. Federal accident investigators said that the plane had shifted early into this high-drag con- figuration shortly before its accident on Friday for reasons that are still unclear. The investiga- tors said it was far too soon to draw any conclu- sions about the crash. Investigators have located almost all of the important pieces of the space plane, which had fallen along a debris field five miles long. That included the fuel tanks and the engine, which were “intact, showed no signs of burn through, no signs of being breached,” said Christopher A. Hart, acting chairman of the National Trans- portation Safety Board. “There is much more we don’t know, and our investigation is far from over,”Hart said during a news conference Sun- day night at the Mojave Air and Space Port in California. In a statement Sunday, Virgin Galactic re- sponded to criticism that the design of Space- ShipTwo was flawed and that the test flights were reckless. “At Virgin Galactic, we are dedi- cated to opening the space frontier, while keep- ing safety as our ‘North Star,’” the company said. “This has guided every decision we have made over the past decade, and any suggestion to the contrary is categorically untrue.” Caceres said the new space entrepreneurs were good at creating excitement about their ventures. Before Friday’s accident, about 700 people had reserved seats on Virgin Galactic, with tickets costing $250,000 each. “You are talking about a brand new era of space,” Caceres said. “You have personalities like Richard Branson and Elon Musk and Jeff Bezos, who are not engineers. These are dif- ferent kinds of people and they can generate a lot of excitement and capital investors who are willing to give you a lot of money.” However, he added, “the downside is that if you have prob- lems, you have all this attention focused on you.” International New York Times Risk and cost in travelling to stars Two back-to-back explosions are a stark reminder that the path to space is arduous for private companies UNFORTUNATE OCCURENCES: The wreckage of the Virgin Galactic’s SpaceShipTwo, which crashed into the Mojave Desert, killing one pilot and injuring another on Friday. (INSET) An unmanned Orbital Sciences rocket exploded after liftoff in Virginia last Tuesday. AFP/AP Third hand smoke to have lingering effect Third hand smoke con- tinues to harm health even hours after smok- ing ends, scientists at the US Department of Energy’s Lawrence Berkeley National Laboratory have found. They looked at the levels of more than 50 volatile organic compounds and airborne parti- cles for 18 hours after smoking had taken place. Hugo Destaillats said that in the US, the home is where nonsmokers are most exposed to second and third hand smoke and the goal of their study is to provide information supporting effective protective measures in the home. Destaillats added that many smokers know sec- ondhand smoke is harmful, so they don’t smoke when their kids are present, but if, for example, they stop smoking at 2 pm and the kids come home at 4 pm, up to 60 per cent of the harm from inhaling thirdhand smoke remains. The study found that the total integrated harm rises sharply in the first five hours after a ciga- rette has been smoked, continues to rise for an- other five hours, and doesn’t start to level off until after 10 hours. Switch to healthy diet doesn’t nullify impact of earlier habits A new research has revealed that earlier poor eating habits may impact health even after diet is improved. The scientists used mice to show that even after successful treatment of atherosclero- sis, lowering of blood cholesterol and a change in dietary habits, the effects of an unhealthy lifestyle still affect the way the immune system functions. This change in function occurs largely because poor eating habits alter the way genes express themselves, including genes related to immunity and this change in gene expression (epigenetics) ultimately keeps the risk of cardiovascular disor- ders higher than it would be had there been no exposure to unhealthy foods in the first place. Researcher Erik van Kampen said that this demonstrates the importance of diet-induced changes in the epigenome and encourages fur- ther research into the interaction between di- etary patterns, DNA methylation and disease. John Wherry, Deputy Editor of the Journal of Leukocyte Biology said that the ability of nutri- tional history to have durable affects on immune cells demonstrated in this new report could have profound implications for treatment of diseases with immune underpinnings. ‘Mindfulness’ meditation good for breast cancer survivors Practicing “mindful- ness” meditation or be- ing involved in a sup- port group has a positive physical im- pact at the cellular lev- el in breast cancer survivors, a study conducted by Alberta Health Services’ Tom Baker Cancer Centre and the University of Calgary Department of Oncology has demonstrated. The study points out that telomeres – protein complexes at the end of chromosomes – maintain their length in breast cancer survivors who prac- tise meditation or are involved in support groups, while they shorten in a comparison group with- out any intervention. Linda E. Carlson, lead research, said that they already knew that psychosocial interventions like mindfulness meditation would help one feel bet- ter mentally, but now for the first time they had evidence that they could also influence key as- pects of their biology. A total of 88 breast cancer survivors of around 55 years of age were involved in the study. Most participants had ended treatment two years prior and to be eligible they also had to be experiencing significant levels of emotional distress. All partici- pants had their blood analysed and telomere length measured before and after interventions. WHAT’S THE BUZZ By Shashank S Tiwari I n the interim Union Budget 2014, then finance minister P Chidambaram had an- nounced exemption of service tax on cord blood banking serv- ices. In his budget speech, he had said that “(the) Ministry of Health and Family Welfare has requested that services provid- ed by cord blood banks are also healthcare services and should be exempt from service tax. I propose to accept the request.” The request from the min- istry is a clear indication of con- flict between biomedical agen- cies in India at the level of policy formulation. Given that, in the revised 2013 stem cell research guidelines, the Indian Council of Medical Research (ICMR) has raised concerns over the commercialisation of private cord blood banking in India. It is worth mentioning here that the newly elected BJP-led gov- ernment also did not indicate rolling back of that decision. Cord blood banking is a process of collecting and storing a new born cord blood for har- vesting stem cell. Cord blood is one of the richest sources of stem cell which is widely seen as a potential to treat many in- curable diseases such as spinal injury, muscular dystrophy, Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, dia- betes, retinal pigmentosa etc. There are two types of cord blood banking as per their na- ture: a) public, and b) private cord blood banking. In the for- mer, expectant parents pay a fee to preserve their child’s cord blood while in the latter, the na- ture is altruism. There are more than 15 private cord blood banks in India. The private cord blood banking is seen as a commercial venture which is largely based on hope and hype and raises many ethical, social and gover- nance concerns. The ICMR, jointly with the Department of Biotechnology, updated the 2007 stem cell guidelines in December 2013. In Section 12.1 of stem cell guide- lines, it is stated that “procure- ment and banking of various bi- ological tissues such as umbilical cord blood, placenta, extracted tooth, adipose tissue and other sources of stem cells, with the specific objective of their isolation and/or ex vivo ex- pansion, is increasingly becom- ing a commercial activity”. Further, Section 12.2.2 em- phasises that “there are ethical concerns about the promotional advertisements by private banks offering storage of cord blood for possible future use. Such ad- vertisements are often mislead- ing for the public and lack com- prehensive and accurate information. It may be men- tioned that there is no scientific basis for preservation of cord blood for future self-use and this practice is not recommended.” However, despite these con- cerns, one of the departments of the Ministry and Family Wel- fare requested the government for service tax exemption on cord blood banking services. Self use of cord blood The legitimate question arises whether the ICMR has acknowl- edged that there is not enough scientific evidence in favour of future self-use of the preserved cord blood. It is worth highlight- ing that for biomedical gover- nance, there are two key agen- cies in India working under the Ministry of Health and Family Welfare – ICMR and Central Drugs Standard Control Organ- isation (CDSCO). The ICMR works as an advi- sory body while CDSCO is a reg- ulatory body that primarily oversees manufacturing, sale and distribution of drugs. The CDSCO also approves new drugs and monitors clinical tri- als. It is the licensing authority for cord blood banks in the country. Given the ICMR posi- tion in 2013 stem cell research guidelines, it appears that CD- SCO has requested government for the service tax exemption on cord blood banking services. With the contradictory state- ment of the former FM and the 2013 stem cell research guide- lines, one can infer a serious pol- icy conflict between biomedical agencies in India. This needs to be addressed soon as the pro- liferation of private cord blood banking leads to possible eco- nomic exploitation of expectant parents in the name of ‘biologi- cal insurance’. However, the chances that a particular child will develop a condition requiring cord blood transplantation are very slim. It has been observed that 0.04 per cent (1/2,500) of cord blood units stored would ever be used for autologous transplantation. The reason is that the occur- rence of diseases currently treated with cord blood is small, and many patients would not be eligible for autologous cord blood, including those with ge- netic disorders and leukaemia. In addition, no one knows, whether CDSCO ensures stor- age conditions and quality con- trol especially while shipping the stored cord blood from hos- pitals to banking firms. Since Union health minister Harsh Vardhan is a clinician by pro- fession, one can expect a robust policy regime and an effective monitoring mechanism for cord blood banking in India. (The writer, a scholar of Science and Technology Studies, is based in the USA) Cord blood banking: Ambiguous policy

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Page 1: Cord Blood Banking: Ambiguous Policy

Panorama

Wednesday, November 5, 2014 DECCAN HERALD11

Coppermayhelpprevent

Ebola spread. P12 »

Benefits of sanitation immense, but task ahead is toughByNareshKapoor

Prime Minister Narendra Modi’sSwachh Bharat campaign is a well-thought out move. It needs to be im-

plemented seriously. Human excreta arethe potential source of transmitting manyinfectious diseases such as cholera, ty-phoid, infectious hepatitis, polio, cryp-tosporidiosis, and ascariasis. Ensuring thatpeople have access to safe drinking wateris another critical dimension of sanitation.

Unsafe water, poor sanitation and hy-giene leads to under nutrition, pneumonia,worminfestations,reducedphysicalgrowth,weakenedphysicalfitnessandimpairedcog-nitivefunction,particularlyforchildrenun-der the age of five. Heavy metals, toxic or-ganic and inorganic substances also canpose serious threats to human health andenvironment, particularly when industrialwastes are added to the waste stream.Therefore, benefits of sanitation are im-mense, but the task ahead is not so easy!

ThePMhasgiventhecountrymenataskto be achieved in a holistic manner. Sani-tation is not only about maintaining clean-

liness around human habitats. If looked atin totality, sanitation is all about ensuringa healthy environment to all living crea-tures, which can come by self-realisationand awareness on good health. A surveyconducted by the National Sample SurveyOffice (NSSO), Union Ministry of Statisticsand Programme Implementation betweenJuly 2012 and December 2012 had madesome startling observations, which werebased on the findings covering 4,475 vil-lages in rural areas and 3,522 urban blocksspread over all states and Union Territo-ries. About 88.5 per cent households in ru-ral India had improved source of drinkingwater while the corresponding figure was95.3 per cent in urban India. Among ruralhouseholds, 85.8 per cent had sufficientdrinking water and for urban India the cor-responding figure was 89.6 per cent.

This means that making available safedrinking water to Indian masses is not adifficult task. It just needs one major push,which will bring the whole populace withinthe ambit of pure and safe drinking watersupplychain.Itwillalsotremendouslyhelpanimal husbandry as well. By providing

safe drinking water, we will only save ourpeople suffering from water borne dis-eases. To have pure source of water, overallsanitation needs to be improved upon.What about latrines? The survey showsthat 59.4 per cent and 8.8 per cent house-holdsinruralandurbanIndia,respectively,had no latrine facilities. It needs to be ad-dressed on a priority basis. A healthy Indianeeds toilet facilities for all. About 38.8 and89.6 per cent households in rural and ur-ban India, respectively, had access to ‘im-

proved’ type of latrine.Providingairyaccommodationisanoth-

erimportantdimensionofsanitationgoals.If we force a large populace to live in com-pressed accommodation, then most ofthemwillenduppickingupmanyailments.We will never have healthy children fromthese areas. It is a major problem in urbanIndia, where a chunk of people are con-strained to live in slums against all oddsand health hazards. If one goes by the sur-vey,thenonly26.3and47.1percenthouse-holds in rural India and urban India, re-spectively, had dwelling units with ‘goodventilation.’As much as 31.7 per cent of ru-ral households and 82.5 per cent of urbanhouseholdshad‘improveddrainage’facilityin the environment of their dwelling units.

It is not that people do not want to moveout of slums or squatter settlements, butthey need to be provided with opportuni-ties to do so. At all India level, 70.8 percent of households had cited ‘better ac-commodation’ as the main reason forwhich they thought to move out of slumor squatter settlement whereas 11.7 percent households had identified ‘proximity

to place of work’ as the main reason.

Best practicemodelsThere is a need to spread awareness onsanitation related issues and opting for the‘best practice’ models. We must under-standthatsanitationisacross-cuttingissueand has implications for a variety of devel-opment areas. To attain the target of totalsanitation, we need to work as well-knitunit. Total sanitation has to go beyond justtoilets. Urban women use sanitary napkinsbut in rural areas, women use a piece clothand have no private space to dry the pieceof cloth in sun. It is used while still wet.This has health and hygiene implications.

Sanitation has also a strong connectionwith human dignity and well-being, publichealth, nutrition and even education.Which is why Mahatma Gandhi once said:“Sanitation is more important than inde-pendence.”Sanitation issues should be giv-en priority in our development policy ap-proaches. Its implications need deep studyand greater understanding. The role ofcommunity leadership in changing oldhabits and ways of thinking will be crucial

as our own experience has shown. Simi-larly, sanitation has to be located in an in-tegrated framework of public health policyto ensure that sanitation activities are in-deed adequately funded. For example,hand washing with soap can reduce the in-cidence of acute respiratory infections(ARI’s) by around 23 per cent accordingto the World Health Organisation.

Thereisalsoaneedtodevelopsanitationtechnologies for diverse eco-systems. Newtechnologieshavetobeaffordableandsus-tainable. Traditional water systems hadbeenengineeredinourvillagestooptimisescarceresourcesincludingtheuseofwater.Wemustusescientific ingenuitytotakeIn-diatothenextgenerationofsanitationtech-nologies. Human waste should be treatedas a resource to be recycled. With more ur-banisation and industrialisation, this chal-lenge will gain importance. We have tostrive for sanitation for dignity and health.Good sanitation should be a birthright ofevery citizen of India. Total health will onlycome through total sanitation.(The writer is Director, BLK Super Special-ity Hospital, New Delhi)

By JadMouawad

Space travel has long been the preserve ofgovernments and sci-fi fans, but in recentyearsacropofnewcommercialventures,

often backed by billionaire entrepreneurs, hassought to get into the race.

The list of so-called thrillonaires has onlygrown, along with their ambitions: Jeff Bezos,the Amazon founder who set up Blue Origin tolower the cost of space technology; Elon Musk,who founded SpaceX with the aim of going toMarsoneday;andRichardBranson,whostart-ed the space tourism company Virgin Galactic.

But two recent accidents involving commer-cial rockets have underscored the high risksand soaring costs involved in any spaceflight.

Last Friday, a Virgin Galactic space planeexploded during a test flight over the MojaveDesert, killing one pilot and injuring another.Daysearlier,anOrbitalSciencesrocketcarryinga supply vessel to the International Space Sta-tion blew up seconds after it was launched.

Both accidents are under investigation. Al-though they were unrelated, their occurrencejust days apart was a stark reminder that thepathtospaceisjustasarduousforprivatecom-panies as it is for government-funded pro-grammes.

“The engineering and physics of space tendto be unforgiving, no matter who is doing this,”said Scott Pace, director of the Space Policy In-stitute at George Washington University and aformer assistant administrator at the NationalAeronautics and Space Administration.

The common thread between these newspace initiatives is that they all are looking forwaystosharplycutthecostofspaceflight.With-out that, analysts say, there is no realisticprospect of making spaceflights both routineand affordable in the future.

“What you are seeing playing out are differ-ent experiments, by different groups, tryingdifferent approaches,” Pace said. “To me, thisdoes not call into question the basic logic of re-lying more on the private sector.” The push toprivatisespaceflightisinpartborneofnecessity.Afterpioneeringspaceexplorationandlandingon the moon with programmes like Mercury,Gemini and Apollo, NASA has had to adapt totighterbudgetsandredefineitsmission.Today,one of its main goals is to encourage and fundthe development of commercial space entities.

Lori B. Garver, a former deputy administra-tor at NASA and one of the most prominentadvocates for commercial space during hertenure, said that public funds should focus onactivities that advance technology and providepublic benefits to all, like planetary science. Atthesametime,shesaid,thegovernmentshouldencourage private companies to move aheadand find innovative ways of reducing costs.

“In my view, the private sector has the sameincentive, or even more, to get things right asthe government does,”Garver said. “If we onlytrusted risky things to the government, wewould only fly in government-owned and oper-ated airplanes.”

Many of the current commercial operationshavesomeformofgovernmentsupport.OrbitalSciences is operating under a $1.9 billion con-tract from NASA to deliver cargo to the spacestation.ItsAntaresrocketexplodedonthethirdof eight resupply missions.

The same is true of SpaceX, which was re-cently awarded $2.4 billion by NASA to build atransportationsystemforastronautswithinthenext three years. SpaceX was also the recipientofanearlier$1.4billioncontracttodelivercargoto the space station. Boeing also won a NASAcontractfor$4.6billiontobuildaspacecraftca-pable of flying astronauts to the space station.

SpaceX and Orbital Sciences have sought toreducecostsindifferentways.Orbital’srocketsuse a pair of refurbished engines built in theSoviet Union in the 1960s and 1970s. The en-gineswereintendedforSovietrocketsdestinedfor the moon, but were never used and lay instorage for decades. The engines were refur-bished by an American company and incorpo-rated into the Antares rocket by Orbital.

SpaceX, by contrast, builds its engines for itsFalcon 9 rocket and aims to reduce costs, inthe long term, by reusing the rocket. The com-panyhassucceededinfiringatestrocketcalledGrasshopper, having it hover at around 2,400feet and then returning it to its point of launch.

But its efforts to land Falcon 9 rockets haveso far been unsuccessful, though the companysays it is getting closer. In August, a bigger testrockettryingahigh-altitudetestwasdestroyed

shortly after takeoff. No one was injured.NASA is “looking for cheaper access to

space,” said Marco A. Caceres, a space analystattheTealGroup,aconsultingfirminVirginia.Thetroubleisthatreliabilityandpriceareoftentiedtogether.“Itmaybeunreasonabletoexpectto pay under a certain amount to get a reliablevehicle,”Caceres said. “That comes at a cost.”

To theedgeof spaceVirgin Galactic is an exception to the model ofgovernment-funded launchers. The companyhas been working on an experimental vessel totake paying passengers to the edge of spaceand back.

The craft, called SpaceShipTwo, was de-signedtobelaunchedfromaplane,thenrocketup to its apogee at about 62 miles, an altitudeconsidered the boundary of outer space. At thetop of its ascent, two tail booms would rotateupward into a so-called feathered position in-tended to create more drag and stability, andallow the plane to descend gently back into theatmosphere.

Federal accident investigators said that theplane had shifted early into this high-drag con-figuration shortly before its accident on Fridayfor reasons that are still unclear. The investiga-tors said it was far too soon to draw any conclu-sions about the crash.

Investigators have located almost all of theimportantpiecesofthespaceplane,whichhadfallen along a debris field five miles long. That

included the fuel tanks and the engine, whichwere “intact, showed no signs of burn through,no signs of being breached,” said ChristopherA.Hart,actingchairmanoftheNationalTrans-portation Safety Board. “There is much morewedon’tknow,andourinvestigationisfarfromover,”Hart said during a news conference Sun-day night at the Mojave Air and Space Port inCalifornia.

In a statement Sunday, Virgin Galactic re-sponded to criticism that the design of Space-ShipTwo was flawed and that the test flightswere reckless. “At Virgin Galactic, we are dedi-catedtoopeningthespacefrontier,whilekeep-ing safety as our ‘North Star,’” the companysaid. “This has guided every decision we havemadeoverthepastdecade,andanysuggestionto the contrary is categorically untrue.”

Caceres said the new space entrepreneurswere good at creating excitement about theirventures. Before Friday’s accident, about 700people had reserved seats on Virgin Galactic,with tickets costing $250,000 each.

“You are talking about a brand new era ofspace,” Caceres said. “You have personalitieslike Richard Branson and Elon Musk and JeffBezos, who are not engineers. These are dif-ferent kinds of people and they can generate alot of excitement and capital investors who arewilling to give you a lot of money.”However, headded, “the downside is that if you have prob-lems,youhaveallthisattentionfocusedonyou.”InternationalNewYorkTimes

Risk and cost intravelling to stars

Twoback-to-backexplosionsareastarkreminderthatthepathtospaceisarduousforprivatecompanies

UNFORTUNATEOCCURENCES:Thewreckageof theVirginGalactic’sSpaceShipTwo,whichcrashed into theMojaveDesert,killingonepilotand injuringanotheronFriday. (INSET)AnunmannedOrbitalSciencesrocketexplodedafter liftoff inVirginia lastTuesday.AFP/AP

Thirdhandsmoke to

have lingeringeffectThird hand smoke con-tinues to harm healtheven hours after smok-ing ends, scientists atthe US Department ofEnergy’s LawrenceBerkeley National Laboratory have found.

They looked at the levels of more than 50volatile organic compounds and airborne parti-cles for 18 hours after smoking had taken place.

Hugo Destaillats said that in the US, the homeis where nonsmokers are most exposed to secondand third hand smoke and the goal of their studyis to provide information supporting effective

protective measures in the home.Destaillats added that many smokers know sec-

ondhand smoke is harmful, so they don’t smokewhen their kids are present, but if, for example,they stop smoking at 2 pm and the kids comehome at 4 pm, up to 60 per cent of the harm frominhaling thirdhand smoke remains.

The study found that the total integrated harmrises sharply in the first five hours after a ciga-rette has been smoked, continues to rise for an-other five hours, and doesn’t start to level off untilafter 10 hours.

Switchtohealthydietdoesn’t

nullify impactofearlierhabitsA new research has revealed that earlier pooreating habits may impact health even after diet is

improved. The scientists used mice to show thateven after successful treatment of atherosclero-sis, lowering of blood cholesterol and a change indietary habits, the effects of an unhealthy lifestylestill affect the way the immune system functions.

This change in function occurs largely becausepoor eating habits alter the way genes expressthemselves, including genes related to immunityand this change in gene expression (epigenetics)ultimately keeps the risk of cardiovascular disor-ders higher than it would be had there been noexposure to unhealthy foods in the first place.

Researcher Erik van Kampen said that thisdemonstrates the importance of diet-inducedchanges in the epigenome and encourages fur-ther research into the interaction between di-etary patterns, DNA methylation and disease.

John Wherry, Deputy Editor of the Journal ofLeukocyte Biology said that the ability of nutri-

tional history to have durable affects on immunecells demonstrated in this new report could haveprofound implications for treatment of diseaseswith immune underpinnings.

‘Mindfulness’meditationgood

forbreastcancersurvivorsPracticing “mindful-ness” meditation or be-ing involved in a sup-port group has apositive physical im-pact at the cellular lev-el in breast cancer survivors, a study conductedby Alberta Health Services’ Tom Baker CancerCentre and the University of Calgary Departmentof Oncology has demonstrated.

The study points out that telomeres – proteincomplexes at the end of chromosomes – maintaintheir length in breast cancer survivors who prac-tise meditation or are involved in support groups,while they shorten in a comparison group with-out any intervention.

Linda E. Carlson, lead research, said that theyalready knew that psychosocial interventions likemindfulness meditation would help one feel bet-ter mentally, but now for the first time they hadevidence that they could also influence key as-pects of their biology.

A total of 88 breast cancer survivors of around55 years of age were involved in the study. Mostparticipants had ended treatment two years priorand to be eligible they also had to be experiencingsignificant levels of emotional distress. All partici-pants had their blood analysed and telomerelength measured before and after interventions.

WHAT’S THE BUZZ

By Shashank S Tiwari

In the interim Union Budget2014, then finance ministerP Chidambaram had an-

nounced exemption of servicetaxoncordbloodbankingserv-ices. In his budget speech, hehad said that “(the) Ministry ofHealth and Family Welfare hasrequested that services provid-ed by cord blood banks are alsohealthcare services and shouldbe exempt from service tax. Ipropose to accept the request.”

The request from the min-istry is a clear indication of con-flict between biomedical agen-ciesinIndiaatthelevelofpolicyformulation. Given that, in therevised 2013 stem cell researchguidelines, the Indian Councilof Medical Research (ICMR)has raised concerns over thecommercialisation of privatecord blood banking in India. Itis worth mentioning here thatthe newly elected BJP-led gov-ernment also did not indicaterolling back of that decision.

Cord blood banking is aprocessofcollectingandstoringa new born cord blood for har-vesting stem cell. Cord blood isone of the richest sources ofstem cell which is widely seenas a potential to treat many in-curable diseases such as spinalinjury, muscular dystrophy,Parkinson’sdisease,Alzheimer’sdisease, multiple sclerosis, dia-betes, retinal pigmentosa etc.

There are two types of cordblood banking as per their na-ture: a) public, and b) privatecord blood banking. In the for-mer,expectantparentspayafeeto preserve their child’s cordblood while in the latter, the na-tureisaltruism.Therearemorethan15privatecordbloodbanksin India. The private cord bloodbankingisseenasacommercialventure which is largely basedon hope and hype and raisesmany ethical, social and gover-nance concerns.

The ICMR, jointly with theDepartment of Biotechnology,updated the 2007 stem cellguidelines in December 2013.InSection12.1ofstemcellguide-lines, it is stated that “procure-mentandbankingofvariousbi-ological tissues such asumbilical cord blood, placenta,extracted tooth, adipose tissueand other sources of stem cells,with the specific objective oftheirisolationand/orexvivoex-pansion, is increasingly becom-ing a commercial activity”.

Further, Section 12.2.2 em-phasises that “there are ethicalconcernsaboutthepromotionaladvertisementsbyprivatebanksoffering storage of cord bloodforpossiblefutureuse.Suchad-vertisementsareoftenmislead-ing for the public and lack com-prehensive and accurateinformation. It may be men-

tioned that there is no scientificbasis for preservation of cordbloodforfutureself-useandthispractice is not recommended.”

However, despite these con-cerns, one of the departmentsoftheMinistryandFamilyWel-fare requested the governmentfor service tax exemption oncord blood banking services.

Self useof cordbloodThe legitimate question ariseswhethertheICMRhasacknowl-edged that there is not enoughscientific evidence in favour offuture self-use of the preservedcordblood.Itisworthhighlight-ing that for biomedical gover-nance, there are two key agen-cies in India working under theMinistry of Health and FamilyWelfare – ICMR and CentralDrugsStandardControlOrgan-isation (CDSCO).

The ICMR works as an advi-sorybodywhileCDSCOisareg-ulatory body that primarilyoversees manufacturing, saleand distribution of drugs. TheCDSCO also approves newdrugs and monitors clinical tri-als. It is the licensing authorityfor cord blood banks in thecountry. Given the ICMR posi-tion in 2013 stem cell researchguidelines, it appears that CD-SCOhasrequestedgovernmentfor the service tax exemptiononcordbloodbankingservices.

Withthecontradictorystate-mentoftheformerFM andthe2013 stem cell research guide-lines,onecaninferaseriouspol-icyconflictbetweenbiomedicalagencies in India. This needs tobe addressed soon as the pro-liferation of private cord bloodbanking leads to possible eco-nomicexploitationofexpectantparents in the name of ‘biologi-cal insurance’.

However, the chances that aparticular child will develop acondition requiring cord bloodtransplantationareveryslim.Ithasbeenobservedthat0.04percent (1/2,500) of cord bloodunitsstoredwouldeverbeusedforautologoustransplantation.The reason is that the occur-rence of diseases currentlytreatedwithcordbloodissmall,and many patients would notbe eligible for autologous cordblood, including those with ge-netic disorders and leukaemia.

In addition, no one knows,whether CDSCO ensures stor-age conditions and quality con-trol especially while shippingthestoredcordbloodfromhos-pitals to banking firms. SinceUnion health minister HarshVardhan is a clinician by pro-fession,onecanexpectarobustpolicy regime and an effectivemonitoring mechanism forcord blood banking in India.(The writer, a scholar of ScienceandTechnologyStudies,isbasedin the USA)

Cord blood banking:Ambiguous policy