copyright rib-x, inc. 2005 – all rights reserved susan froshauer, ph.d. president and ceo

Copyright Rib-X, Inc. 2005 – All Rights Reserved

Susan Froshauer, Ph.D.

President and CEO


Our MissionOur Mission

To Rapidly Design and Develop theNext Generation

of Antibiotics Active Against Drug

Resistant Bacteria

Many Antibiotics Inhibit the RibosomeMany Antibiotics Inhibit the Ribosome

50S30S

Zithromax

Biaxin

Zyvox

Ketek

Cleocin

Chloromycetin

Synercid

InhibitorsInhibitors

Aminoglycosides

Tetracyclines

mRNA Decoding Peptide bond formation


Rib-X Business PlanRib-X Business Plan

• Fully exploit Rib-X research and development capability to build a sustainable company

• Establish a strong pipeline of differentiable drugs

• Partnerships to leverage our assets and to expand outreach and global potential

• Revenue via such commercialization partnerships and ultimately a focused Rib-X sales force


Waves of Programs Build PipelineWaves of Programs Build Pipeline

2004 2005 2006 2007

Clinical TrialsPhase 2

Clinical Trials Phase 1

LatePreclinical



CommercialPartnership

IND

IND

IND

2004 2005 2006Copyright Rib-X Inc. 2005 – All Rights Reserved

NCEDevelopmentR02

2007

New Programs

CommercialPartnership

DrugCandidates

DrugCandidates

R03

LatePreclinicalR01

NCE Development

LatePreclinical


Clinical TrialsPhase 3


Business HighlightsBusiness Highlights

• Research Initiated, June, ‘01

• $ 9.5 MM, Series A, Dec., ‘01

• $ 63.5 MM, Series B, May ’03

• Multiple, Parallel & Distinct Drug Dev Programs

• Clinic with 1st Program during 2005

• Commercial Partnerships in Phase I/II


Rib-X CultureRib-X Culture

• 50 Employees

• 42 Ph.D.s, 1 MBA, 3 Specialized Training

• Local Institutions- Yale, Large Pharma

• US Biotech Companies and other Academic Institutions

• International


Rib-XBenefits from CT

Rib-XBenefits from CT

Nucleation and Cash Flow


Scientific FoundersScientific Founders

Thomas A. Steitz, Ph.D. • SAB Chair and Co-founder• Yale University

Peter B. Moore, Ph.D.• Co-founder• Yale University

Harry F. Noller, Ph.D.• Co-founder• University of California,

Santa Cruz

John N. Abelson, Ph.D.• Co-founder• California Institute

of Technology

William L. Jorgensen, Ph.D.• Co-founder• Yale University


Yale Technology TransferYale Technology Transfer

Exclusive Licenses to:

• Ribosome Crystal Structure

Patent

Know-how

• Computational Chemistry Software & Code


Private Equity Investors, Including CT Venture CapitalPrivate Equity Investors, Including CT Venture Capital

• ABS Ventures

• Axiom Venture Partners

• Cardinal Partners

• Connecticut Innovations

• EuclidSR Partners

• Oxford Bioscience Partners

• S.R. One, Limited

• Warburg Pincus (Series B Lead)

• Zero Stage Capital


Connecticut Innovations Valuable to Rib-XConnecticut Innovations Valuable to Rib-X

• Connecticut Innovations Private Equity Fund

Seed Investors ($ 1.2 MM)

• Connecticut Innovation’s Lab Space

Science Park Incubator Space

Modest interest loan to build 29,000 square ft George Street Laboratory Facilities ($ 3.1 MM, 5yrs)


Connecticut Benefits- Increase Rib-X RunwayConnecticut Benefits- Increase Rib-X Runway

• R & D Tax Credit

• Preferential Personal Property Tax

• New Haven Enterprise Zone


Rib-X Outreach to Organizations Smoothes the WayRib-X Outreach to Organizations Smoothes the Way• Yale

SOM Library Fee for Service- Equipment, Keck Facility Scientific Community Educated Workforce

• CBIA Bulk buying power (health insurance) HR Resources/Information Training and Key Certifications

• CURE On-line info (permitting requirements) Promotion of Biotech Cluster Build


CT Might Do More….CT Might Do More….

Patient Money and Incentives


Stimulating the Biotech Cluster Stimulating the Biotech Cluster

• $$ Seed Funding Mezzanine

• Diversity of Business Plans- Synergies- Benefits

• Involve Local Pharma/Biotech- Define Needs

• Administrative Resources

• Connected, Committed, Savy Mentors

• Visionary Facilities- High Cost Equipment


Susan Froshauer, Ph.D.President & CEO(203) [email protected]

Thank you.

copyright rib-x, inc. 2005 – all rights reserved susan froshauer, ph.d. president and ceo

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