copyright 2008 © mattioli engineering all rights reserved dermoelectroporation®: the only one us...
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Copyright 2008 © Mattioli Engineering All rights reserved
DDermoelectroporation®ermoelectroporation®: the : the only one US FDA approved only one US FDA approved
alternative to injectionalternative to injection
MMattioli Engineeringattioli Engineering
Copyright 2008 © Mattioli Engineering All rights reserved
DDermoelectroporation®ermoelectroporation®
The only top No.1 The only top No.1 technology alternative to technology alternative to
injectionsinjections
Copyright 2008 © Mattioli Engineering All rights reserved
Dermoelectroporation® is a technology that allows Dermoelectroporation® is a technology that allows product delivery into the various layers of the skin or product delivery into the various layers of the skin or subcutaneous tissues. subcutaneous tissues.
Any water soluble ingredients can be inserted into the Any water soluble ingredients can be inserted into the skin without additional carrying Gels.skin without additional carrying Gels.
Dermoelectroporation® utilizes the skin water basedDermoelectroporation® utilizes the skin water basedchannels to allow product penetration due tochannels to allow product penetration due tocontrolled current pulses delivered to the patient.controlled current pulses delivered to the patient.
DDermoelectroporation® ermoelectroporation®
Copyright 2008 © Mattioli Engineering All rights reserved
Mattioli Engineering microdermabrasion leader since Mattioli Engineering microdermabrasion leader since 1991 1991
Empowering Skin Care specialists across the world with Empowering Skin Care specialists across the world with revolutionary technologies to treat skin. revolutionary technologies to treat skin.
Additional opportunities to further enhance delivery of Additional opportunities to further enhance delivery of active ingredients into the skin was sought.active ingredients into the skin was sought.
Combining the concept of Meso therapy (by Dr. Pistor, Combining the concept of Meso therapy (by Dr. Pistor, 1952) and Mattioli Engineering’s technical expertise led 1952) and Mattioli Engineering’s technical expertise led to development of Dermoelectroporation.to development of Dermoelectroporation.
WWhy Dermoelectroporation® hy Dermoelectroporation®
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WWhat Dermoelectroporation is nothat Dermoelectroporation is not
MicrodermabrasionMicrodermabrasion GalvanicGalvanic IonthophoresisIonthophoresis Ultrasound / SonophoresysUltrasound / Sonophoresys AquaphoresysAquaphoresys Massagers Massagers Laser deviceLaser device
Transderm® is the ONLY and REAL alternative to injections. Transderm® is the ONLY and REAL alternative to injections.
Copyright 2008 © Mattioli Engineering All rights reserved
EExistingxisting Technolog Technologies for deliveryies for delivery
MicrodermabrasionMicrodermabrasion
Medical and Aesthetic applicationMedical and Aesthetic application – 11stst transdermal pathway transdermal pathway– Skin surface action onlySkin surface action only– No current appliedNo current applied
– Small sized molecules onlySmall sized molecules only– Low delivery rate Low delivery rate
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EExistingxisting Technolog Technologiesies
Low Dc current level applied
Traditional Galvanic (1to 5mA)Traditional Galvanic (1to 5mA)
Aesthetic applicationAesthetic application – Pushes ions into the skin.Pushes ions into the skin.– Low Dc current level applied.Low Dc current level applied.
– Ineffective for high weight molecules.Ineffective for high weight molecules.– Pre-charged compounds needed.Pre-charged compounds needed.– Small sized molecules only.Small sized molecules only.– Substance PH will change.Substance PH will change.– Electrolysis (product separation).Electrolysis (product separation).
Copyright 2008 © Mattioli Engineering All rights reserved
EExistingxisting Technolog Technologies for deliveryies for delivery
Traditional Pulsed IonthophoresisTraditional Pulsed Ionthophoresis (1to 5mA)(1to 5mA)
Medical and Aesthetic applicationMedical and Aesthetic application – Pushes ions into the skin.Pushes ions into the skin.– Low Ac current level applied.Low Ac current level applied.
– Ineffective for high weight molecules.Ineffective for high weight molecules.– Pre-charged compounds needed.Pre-charged compounds needed.– Small sized molecules only.Small sized molecules only.– Substance PH may change.Substance PH may change.– Electrolysis (product separation).Electrolysis (product separation).
Sinus Low Ac current level applied
Alternative Low Ac current level applied
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EExistingxisting Technolog Technologies for deliveryies for delivery
Electroporation Electroporation
In lab application onlyIn lab application only
– MacromoleculesMacromolecules delivery delivery
– High peak currents needed High peak currents needed
to porate the external skinto porate the external skin
layers (18,000volts)layers (18,000volts)– High risk of High risk of permanent permanent
skin damageskin damage– Many Many Adverse effectsAdverse effects
High peak currents
Ionthophoresys currents
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EExistingxisting Technolog Technologies for deliveryies for delivery
High Frequency vibration 3MHz or higher
UltrasoundsUltrasounds
Medical and Aesthetic applicationMedical and Aesthetic application
– No current appliedNo current applied – High vibration frequency on the skinHigh vibration frequency on the skin
– Ineffective Ineffective for high weight moleculesfor high weight molecules– Small sized molecules Small sized molecules onlyonly
Copyright 2008 © Mattioli Engineering All rights reserved
EExistingxisting Technolog Technologies for deliveryies for delivery
High Frequency vibration Lower than 3 MHz
Sonophoresys (Sound)Sonophoresys (Sound)
Medical and Aesthetic applicationMedical and Aesthetic application
– Low frequency UltrasoundLow frequency Ultrasound
– Ineffective Ineffective for high weight moleculesfor high weight molecules– Small sized molecules Small sized molecules onlyonly
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EExistingxisting Technolog Technologies for deliveryies for delivery
AquaphoresysAquaphoresys (1to 5mA)(1to 5mA)
Medical and Aesthetic applicationMedical and Aesthetic application
– Ultrasounds + current stimulationUltrasounds + current stimulation– Low Ac current Low Ac current – High freq. UltrasoundsHigh freq. Ultrasounds
– Ineffective Ineffective for high weight moleculesfor high weight molecules– Small sized molecules Small sized molecules onlyonly– Ionic drug solutions PH may changeIonic drug solutions PH may change– Electrolysis (ionic separation)Electrolysis (ionic separation)
Low Ac current level applied
Copyright 2008 © Mattioli Engineering All rights reserved
DDermoelectroporation®ermoelectroporation®
Is a Proprietary Patented Technology from Mattioli Engineering Engineering.
The only US FDA Cleared Device as alternative to injections (Top n.1) Micro-molecules and MACRO-molecules are safely delivered. Using the skin’s water based “channels” (aquaporins). Low and controlled current pulses delivered to the skin No skin damage, no adverse effects, no contraindications No effect on the substance being inserted/”injected”. Faster than traditional Ionthophoresis / Galvanic devices (same
amount of product)
Copyright 2008 © Mattioli Engineering All rights reserved
DDermoelectroporation®ermoelectroporation®
What the Technology is What the Technology is used for?used for?
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FOR EDUCTIONAL PURPOSES ONLY
Dermatology treatments.Dermatology treatments.Skin rejuvenation and bio revitalization. Skin rejuvenation and bio revitalization. Cellulite treatments.Cellulite treatments.Fat depositsFat depositsHyperHidrosis (Botulinum toxine administration)HyperHidrosis (Botulinum toxine administration)Acne pathologies.Acne pathologies.Hormone replacement treatmentsHormone replacement treatmentsPre laser treatments.Pre laser treatments.Pre and post plastic surgery sessions.Pre and post plastic surgery sessions.Replacing injections for Mesotharapy applications.Replacing injections for Mesotharapy applications.
Transderm® Meso® System®Transderm® Meso® System®
Copyright 2008 © Mattioli Engineering All rights reserved
FOR EDUCTIONAL PURPOSES ONLY
Transderm® Meso® System ®Transderm® Meso® System ®
Meso-Botulinum Toxine applications.Meso-Botulinum Toxine applications.Wrinkles treatments.Wrinkles treatments.Stretch mark treatments.Stretch mark treatments.Actinic Keratosis applications.Actinic Keratosis applications.Steroids applicationsSteroids applicationsPain managementPain managementRheumatic and post rheumatic pathologies.Rheumatic and post rheumatic pathologies.Sports medicine (F.C. Juventus)Sports medicine (F.C. Juventus)
Copyright 2008 © Mattioli Engineering All rights reserved
DDermoelectroporation®ermoelectroporation®
Who is this Top No.1 Who is this Top No.1 technology available for?technology available for?
Copyright 2008 © Mattioli Engineering All rights reserved
Dermoelectroporation® is available for:Dermoelectroporation® is available for:
Skin Care Specialists that want to optimize the delivery of a Skin Care Specialists that want to optimize the delivery of a high range of ingredients and not only a very few of high range of ingredients and not only a very few of them…..them…..
Clinics/salons that realize the limitation of conventional Clinics/salons that realize the limitation of conventional beauty treatments and want to offer additional beauty treatments and want to offer additional treatments with a significant improvement in efficacy to treatments with a significant improvement in efficacy to move ahead off common level clinics / salon….move ahead off common level clinics / salon….
..Providing a wide range of applications in only one device ..Providing a wide range of applications in only one device and/or improving existing protocols on use.and/or improving existing protocols on use.
DDermoelectroporation® ermoelectroporation®
Copyright 2008 © Mattioli Engineering All rights reserved
MMattioli Engineering’s Solutionattioli Engineering’s Solution
Scientific principleScientific principle
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Dermoelectroporation® utilizes the skin water basedDermoelectroporation® utilizes the skin water basedchannels to allow ionic drug solutions to penetrate due tochannels to allow ionic drug solutions to penetrate due tocontrolled current delivered to the patient.controlled current delivered to the patient.
((Dermoelectroporation® stimulates the opening of the existing water based Dermoelectroporation® stimulates the opening of the existing water based channels to channels to
create a transdermal passage to deliver drugs deep into the derma.)create a transdermal passage to deliver drugs deep into the derma.)
DDermoelectroporation® ermoelectroporation®
Copyright 2008 © Mattioli Engineering All rights reserved
SScientific principlecientific principle
-Reproduces transient changes in skin microstructure Reproduces transient changes in skin microstructure
-Current flowing through the extra cellular matrix -Current flowing through the extra cellular matrix
(mainly composed by water, ions, and glycosaminoglycans) to make the (mainly composed by water, ions, and glycosaminoglycans) to make the
--Long-chained glycosaminoglycans to ,transiently, orient themselves to Long-chained glycosaminoglycans to ,transiently, orient themselves to create “channels” create “channels” (Water based ones)(Water based ones) allowing the delivery of allowing the delivery of Macromolecules Macromolecules through the skin. through the skin.
No cell injury No cell injury (i.e. fragmentation of cytoplasm or nucleus, abnormalities of (i.e. fragmentation of cytoplasm or nucleus, abnormalities of plasma membrane due to low current intensity used).plasma membrane due to low current intensity used).
((V., Ruggiero, M., and Magnelli, L.: Angiogenesis and the unique nature of tumor matrix. Mol. Biotech. 21: 85-90, 2002.).V., Ruggiero, M., and Magnelli, L.: Angiogenesis and the unique nature of tumor matrix. Mol. Biotech. 21: 85-90, 2002.).
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Cells
SScientific principlecientific principle
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MMattioli Engineering’s Solutionattioli Engineering’s Solution
Substances drivenSubstances driventthroughhrough
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Transderm® Meso® System ®Transderm® Meso® System ®
FOR EDUCTIONAL PURPOSES ONLY
What substances are driven?What substances are driven?•Collagen•Hyaluronic Acid•Lidocaine•L-Carnitine•Vitamins•Amino Acids•Heparin•Elastine•Mesotharapy Procedures•Glutathione
•Hormone Replacement•Phosphatidylcoline•Aminophylline•Hyaluronidase•MTE-4•Ionic skin tissue growth gel•Steroids•Botulinum toxine (Studies available from May 2007)(Studies available from May 2007)•Growth Factors•Lymidiral•Veno-M•Placentex•Diclofenac
•And many other “cocktails”…..
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EExistingxisting Technolog Technologiesies
Why Transderm has been Why Transderm has been indicated as alternative to indicated as alternative to
injectioninjection
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MMattioli Engineering’s Solutionattioli Engineering’s Solution
Dermoelectroporation®: Dermoelectroporation®: Delivery pulses principleDelivery pulses principle
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DDelivery pulses principles elivery pulses principles
Dermoelectroporation (0 - 5mA)Human use
– Low and controlled current - No skin damage– Macro molecules deliverable– No adverse effects– No Contraindications– To be used on human beings Low and controlled Low and controlled
current level appliedcurrent level applied
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DDermoelectroporation®ermoelectroporation®
Practicing with Practicing with Dermoelectroporation®.Dermoelectroporation®.
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MMattioli Engineering’s Solutionattioli Engineering’s Solution
Dermoelectroporation is a 2 steps Procedure:Dermoelectroporation is a 2 steps Procedure:
It forsees a preventive Microdermabrasion to reduce the skin It forsees a preventive Microdermabrasion to reduce the skin impedance and to optimize the useimpedance and to optimize the use
ofof
Transderm® Meso® System ® for transdermal delivery of productsfor transdermal delivery of products
Copyright 2008 © Mattioli Engineering All rights reserved
MMattioli Engineering’s Solutionattioli Engineering’s Solution
Copyright 2008 © Mattioli Engineering All rights reserved
MMattioli Engineering’s Solutionattioli Engineering’s Solution
Dermoelectroporation®: Dermoelectroporation®: Features,Advantages & Features,Advantages &
BenefitsBenefits
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FeaturesFeatures of Dermoelectroporation® of Dermoelectroporation®
- Capability to transdermally deliver ionic drug solutions
- Capability to transdermally deliver both micro and macromolecules (greater than 800,000Dalton)
- No electrolysis of ionic drug solution or variation in the ionic drug solution pH
- Both positive and negative ions of the drug are transdermally delivered at the same time
- Performing Microdermabrasion first promotes the transdermal delivery rate
- Reproducibility of dose delivered
- Non-invasive
- No trauma from injections
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-Transderm fits perfectly in already existing protocols to improve -Transderm fits perfectly in already existing protocols to improve and shorten outcome and shorten outcome (compatibility)(compatibility)..
-Transderm allows users to have so many different applications in -Transderm allows users to have so many different applications in only one device.only one device.(substances delivered)(substances delivered)
-Transderm cancel completely the fear of needles and other -Transderm cancel completely the fear of needles and other invasive treatments.invasive treatments.(Needles free injection system)(Needles free injection system)
-Transderm is the Top N.1 technology FDA cleared as “alternative -Transderm is the Top N.1 technology FDA cleared as “alternative to injections”.to injections”.
AdvantagesAdvantages of Dermoelectroporation® of Dermoelectroporation®
Copyright 2008 © Mattioli Engineering All rights reserved
The Growth of non surgical procedures. (source (source Aesthetic Buyers Aesthetic Buyers
Guide 2006 )Guide 2006 )
“Growth of non-surgical aesthetic procedures is outpacing surgical
procedures by a margin of three to one, with dermal fillers being only
second to Botox in this category. This demonstrates that the consumer
shift towards less invasive correction and heavily towards the non
invasive segment.”
“The global dermal fillers market was valued at $442 million in 2005 – an
increase of 25% from the previous year.”
AdvantagesAdvantages of Dermoelectroporation® of Dermoelectroporation®
Copyright 2008 © Mattioli Engineering All rights reserved
BODY SHAPING MARKET
Aesthetic Buyers Guide 2006 –
“The global market for body shaping devices continues to expand strongly. Over
the next five years, overall sales of body shaping systems will rise 25.1% per year,
from $182.8 million in 2005 to an estimated $559.9 million in 2010.”
“In 2005, almost 69% of procedure fees were represented by liposuction, asurgical technique that offers virtually guaranteed removal of small fat
deposits ina single procedure. However, risks associated with surgery and relatively
longrecovery times will result in minimal procedure growth of just 3.5% per
year forliposuction, while newer, non-invasive therapies will expand rapidly.”
AdvantagesAdvantages of Dermoelectroporation® of Dermoelectroporation®
Copyright 2008 © Mattioli Engineering All rights reserved
Benefits Benefits of Dermoelectroporation®of Dermoelectroporation®
Some of the Benefits Some of the Benefits Dermoelectroporation®Dermoelectroporation® can give: can give:
1)1) Patients are not more afraid of any “was-invasive” procedurePatients are not more afraid of any “was-invasive” procedure2)2) No psychological shock in getting the treatment done No psychological shock in getting the treatment done 3)3) No risk of contamination hazard due to needlesNo risk of contamination hazard due to needles4)4) Increasing number of treatments per day/month because…Increasing number of treatments per day/month because…
Copyright 2008 © Mattioli Engineering All rights reserved
Benefits Benefits of Dermoelectroporation®of Dermoelectroporation®
TransdermTransdermIncreases theIncreases thenumber ofnumber ofhappy patient’s! happy patient’s!
..word of mouth!!..word of mouth!!
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MMattioli Engineering’s Solutionattioli Engineering’s Solution
Dermoelectroporation®: Dermoelectroporation®: ResultsResults
Copyright 2008 © Mattioli Engineering All rights reserved
Courtesy of Dr. Jaggy Rao, MD University of Edmonton ,Alberta,CanadaCourtesy of Dr. Jaggy Rao, MD University of Edmonton ,Alberta,Canada
Before
RRhythids - Canadahythids - Canada
After
2 sessions – 2 weeks apart each other3ml Hyaluronic acid 15mg/ml
Copyright 2008 © Mattioli Engineering All rights reserved
Stratum CorneumStratum Corneum
EpidermisEpidermis
DermisDermis
HypodermisHypodermis
1.700.000dalton Hyaluronic acid delivery through the dermis to hypodermis using Transderm® ionto system1.700.000dalton Hyaluronic acid delivery through the dermis to hypodermis using Transderm® ionto system
Courtesy of Dr. Jaggy Rao, MD University of Edmonton ,Alberta,CanadaCourtesy of Dr. Jaggy Rao, MD University of Edmonton ,Alberta,CanadaBBiopsy on HA - Canadaiopsy on HA - Canada
Copyright 2008 © Mattioli Engineering All rights reserved
CCellulite treatment - Italyellulite treatment - Italy
Mattioli Engineering © All rights reserved – Do not distribute – For internal use only
FOR EDUCTIONAL PURPOSES ONLY
AfterBefore
Hairdresser , 44 years oldHairdresser , 44 years old
Courtesy of Prof. Massirone, Courtesy of Prof. Massirone, President A.M.E , A.M.I.Est. -. Milan ItalyPresident A.M.E , A.M.I.Est. -. Milan Italy
11 patients - 11 patients - Females.Females.
II, III and IV level II, III and IV level cellulite.cellulite.
8 consecutive weeks, 8 consecutive weeks, once per week once per week session.session.
1 ml Aminophylline + 1 ml Aminophylline + 2 ml Lymdiaral + 2 ml 2 ml Lymdiaral + 2 ml Veno-N. Veno-N.
Copyright 2008 © Mattioli Engineering All rights reserved
CCellulite treatment - Italyellulite treatment - Italy
Mattioli Engineering © All rights reserved – Do not distribute – For internal use only
FOR EDUCTIONAL PURPOSES ONLY
AfterBefore
Shopkeeper, 34 years oldShopkeeper, 34 years old
Courtesy of Prof. Massirone, Courtesy of Prof. Massirone, President A.M.E , A.M.I.Est. -. Milan ItalyPresident A.M.E , A.M.I.Est. -. Milan Italy
11 patients - 11 patients - Females.Females.
II, III and IV level II, III and IV level cellulite.cellulite.
8 consecutive weeks, 8 consecutive weeks, once per week once per week session.session.
1 ml Aminophylline + 1 ml Aminophylline + 2 ml Lymdiaral + 2 ml 2 ml Lymdiaral + 2 ml Veno-N. Veno-N.
Copyright 2008 © Mattioli Engineering All rights reserved
CCellulite & Adiposity Treatment -ellulite & Adiposity Treatment -USAUSA
FOR EDUCTIONAL PURPOSES ONLY
before
after
Cellulite Treatment Protocol:Delivered every 1-2 weeks until desired result is achieved (usually 3-8 treatments) Areas are referred to as abdomen, thighs, etc.Per 5 cc syringe:4 cc Hyaluronidase 300 units/mL+ 4 cc L-carnitine 500 mg/mL+2 cc Phosphatidylcholine 100 mg/mL4 syringes used per session.
Courtesy of Dr. suneil JainCourtesy of Dr. suneil Jain -. Scottsdale AZ - USA -. Scottsdale AZ - USA
Copyright 2008 © Mattioli Engineering All rights reserved
PPost-liposuction correction for ost-liposuction correction for abnormal fat deposition-USAabnormal fat deposition-USA
FOR EDUCTIONAL PURPOSES ONLY
before
after
Courtesy of Dr. suneil JainCourtesy of Dr. suneil Jain -. Scottsdale AZ - USA -. Scottsdale AZ - USA
Body Sculpting Protocol: Delivered every 1-2 weeks until desired result is achieved (usually 2-10 treatment) Areas are referred to as abdomen, lateral thigh, medial thigh & back.Per 5 cc syringe: 2 cc L-carnitine 500 mg/mL + 3 cc Phosphatidylcholine 100 mg/mL4 syringes used per session.
Copyright 2008 © Mattioli Engineering All rights reserved
Courtesy of Dr. Chuah, MD Kuala Lumpur - MalaysiaCourtesy of Dr. Chuah, MD Kuala Lumpur - Malaysia
LLifting - Malaysiaifting - Malaysia
Delivered once for total Delivered once for total of 1 treatment.of 1 treatment.
Prepare solution using a 5cc5cc syringe filled by Hyaluronic Acid cocktails through Super Super PLDPLD.
Ultrapeel Ultrapeel microdermabrasionmicrodermabrasion - arm test, 2 passes mid lvl power -followed by hand gommage. Deliver transdermally HA cocktail 10mins10mins each side medium time using TransdermTransderm® ® technology.
Apply Calmin MaskMask for 10 minutes
Apply BasicBasic cream and SPF SPF cream
Copyright 2008 © Mattioli Engineering All rights reserved
Stratum CorneumEpidermisDermisHypodermis
800.000dalton Hyaluronic acid delivery 800.000dalton Hyaluronic acid delivery throughthrough the dermis to hypodermis using Transderm® ionto system the dermis to hypodermis using Transderm® ionto system
BBiopsy with Hyaluronic acidiopsy with Hyaluronic acidCourtesy of Dr. Stefania Pacini, MD University of Florence,ItalyCourtesy of Dr. Stefania Pacini, MD University of Florence,Italy
Copyright 2008 © Mattioli Engineering All rights reserved
Test of minor on an untreated part
FOR EDUCTIONAL PURPOSES ONLY
BBotulinum toxine for HyperHydrosisotulinum toxine for HyperHydrosisCourtesy of Dr. M.CavalliniCourtesy of Dr. M.Cavallini , Plastic surgery specialist , Milan , Italy , Plastic surgery specialist , Milan , Italy
Before
After
6 cases – all female patients6 cases – all female patients Sweating measurement with Test of minorSweating measurement with Test of minor Delivery of 50 units of botulinum toxine per axilla Delivery of 50 units of botulinum toxine per axilla
(diluted with 2ml saline solution)(diluted with 2ml saline solution) Time of treatment: 10 minutesTime of treatment: 10 minutes Control after 2 weeksControl after 2 weeks Test of minorTest of minor to quantify the result after 14 – 20 to quantify the result after 14 – 20
days.days.
Copyright 2008 © Mattioli Engineering All rights reserved
–Botulinum Toxin magnificationBotulinum Toxin magnification
150.000dalton Botulinum Toxin transdermal delivery till muscles using Transderm® ionto system150.000dalton Botulinum Toxin transdermal delivery till muscles using Transderm® ionto system
Courtesy of Dr. Stefania Pacini, MD University of Florence , ItalyCourtesy of Dr. Stefania Pacini, MD University of Florence , Italy
BBiopsy with Botulinum toxineiopsy with Botulinum toxine
Stratum CorneumStratum Corneum
EpidermisEpidermis
DermisDermis
Deep HypodermisDeep Hypodermis
MusclesMuscles
Scientific complete doocumentation available from April 2007Scientific complete doocumentation available from April 2007
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MMattioli Engineering’s Solutionattioli Engineering’s Solution
Dermoelectroporation®: Dermoelectroporation®: Summarizing……Summarizing……
Copyright 2008 © Mattioli Engineering All rights reserved
InIn other words…. other words….
Dermoelectroporation technology ……
– utilizesutilizes the skin’s water based “channels” – IncreaseIncrease the skin permeabilitypermeability to allow transdermal delivery of
micro-molecules and macro-moleculesmacro-molecules – ControlledControlled electrical pulsespulses delivery ((Average current value on the patient is zero)Average current value on the patient is zero)..
– No modificationNo modification of the ionic drug solutions pHpH and nono electrolysiselectrolysis effect of the ionic solution itself.
– Dermoelectroporation is fasteris faster than traditional Ionthophoresis devices to deliver the same amount of ionic drug solution.
– Dermoelectroporation does not needdoes not need any skin pH-Compensating patch, nor pre-charged compounds, nor carrying Gel nor others media to get the drug successfully delivered.