Editorial GroupBruce D. Cheson, MD, EditorGeorgetown UniversityWashington, DC

Bernard A. Mason, MD, Associate EditorUniversity of PennsylvaniaPhiladelphia, Pennsylvania

AuthorsFrederick R. Appelbaum, MDFred Hutchinson Cancer Research CenterSeattle, Washington

Ernest C. Borden, MDCleveland Clinic FoundationCleveland, Ohio

Otis W. Brawley, MDEmory UniversityAtlanta, Georgia

Jan Buckner, MDMayo ClinicRochester, Minnesota

Edward P. Gelmann, MDGeorgetown UniversityWashington, DC

Parkash Gill, MDUniversity of Southern California, Norris Cancer CenterLos Angeles, California

Gabriel N. Hortobagyi, MD, FACPM.D. Anderson Cancer CenterHouston, Texas

Charles Loprinzi, MDMayo ClinicRochester, Minnesota

Robert Maki, MD, PhDMemorial HospitalNew York, New York

Maurie Markman, MDM.D. Anderson Cancer CenterHouston, Texas

John Marshall, MDGeorgetown UniversityWashington, DC

Joanne Mortimer, MDUniversity of California, San DiegoSan Diego, California

David G. Pfister, MDMemorial Sloan-Kettering Cancer CenterNew York, New York

Howard I. Scher, MDMemorial Sloan-Kettering Cancer CenterNew York, New York

Joan Schiller, MDUniversity of WisconsinMadison, Wisconsin

Lynn M. Schuchter, MDUniversity of Pennsylvania Cancer CenterPhiladelphia, Pennsylvania

Associate AuthorRichard J. Robbins, MDMemorial Sloan-Kettering Cancer CenterNew York, New York

ReviewersAlaa H. Addasi, MDUniversity of MinnesotaMinneapolis, Minnesota

G. Thomas Budd, MDCleveland Clinic FoundationCleveland, Ohio

Paul B. Chapman, MDMemorial Sloan-Kettering Cancer CenterNew York, New York

Gary I. Cohen, MD, FACPGreater Baltimore Medical CenterBaltimore, Maryland

Dale H. Cowan, MD, JDCleveland Clinic FoundationIndependence, Ohio

David Cunningham, MD, FRCPRoyal Marsden HospitalSurrey, England

Russell F. DeVore III, MDEast Tennessee Oncology/HematologyNashville, Tennessee

Contributors

v

Peter D. Eisenberg, MDCalifornia Cancer CareGreenbrae, California

Paul F. Engstrom, MDFox Chase Cancer CenterPhiladelphia, Pennsylvania

Nancy R. Feldman, MDOlive View-University of California, Los Angeles,Medical CenterSylmar, California

Patrick J. Flynn, MDMinnesota Oncology Hematology, PAMinneapolis, Minnesota

Arlene A. Forastiere, MDThe Sidney Kimmel Comprehensive Cancer Center atJohns Hopkins Baltimore, Maryland

Stephen J. Forman, MDCity of HopeDuarte, California

William J. Gradishar, MDNorthwestern UniversityChicago, Illinois

Stuart A. Grossman, MDJohns Hopkins UniversityBaltimore, Maryland

William N. Hait, MD, PhDUniversity of Medicine and Dentistry of New JerseyNew Brunswick, New Jersey

Orion M. Howard, MDNorthwest Connecticut Hematology/OncologyAssociatesTorrington, Connecticut

Karen L. Kelly, MDUniversity of ColoradoDenver, Colorado

Catherine E. Klein, MDDenver Veterans Administration Hospital Denver, Colorado

Corey J. Langer, MD, FACPFox Chase Cancer CenterPhiladelphia, Pennsylvania

Stuart M. Lichtman, MD, FACPNorth Shore University HospitalManhasset, New York

Laurie J. Lyckholm, MDVirginia Commonwealth UniversityRichmond, Virginia

Jewraj G. Maheshwari, MDOwensboro Cancer CenterOwensboro, Kentucky

Edith A. Perez, MDMayo Clinic Jacksonville, Florida

John E. Pippen, Jr., MD, FACPBaylor Sammons Cancer CenterDallas, Texas

Nicholas J. Robert, MDFairfax/Northern VA Hem/OncFairfax, Virginia

Mace L. Rothenberg, MDVanderbilt-Ingram Cancer CenterNashville, Tennessee

Scott M. Schuetze, MD, PhDUniversity of WashingtonSeattle, Washington

Jennifer E. Schwartz, MDIndiana UniversityIndianapolis, Indiana

Michael Schwartz, MDMt. Sinai Comprehensive Cancer CenterMiami Beach, Florida

Visaharan Sivasubramaniam, MDUniversity of KentuckyLexington, Kentucky

Marvin J. Stone, MDBaylor Sammons Cancer CenterDallas, Texas

Christopher J. Sweeney, MBBSIndiana UniversityIndianapolis, Indiana

Martin S. Tallman, MDNorthwestern UniversityChicago, Illinois

James Tate Thigpen, MDUniversity of Mississippi School of MedicineJackson, Mississippi

Robert F. Todd, MD, PhDUniversity of Michigan Medical CenterAnn Arbor, Michigan

Alan P. Venook, MDUniversity of California, San Francisco, Cancer CenterSan Francisco, California

vi

Charles F. von Gunten, MD, PhDSan Diego HospiceSan Diego, California

Jeffrey L. Wolf, MDAltaBates Comprehensive Cancer CenterBerkeley, California

ConsultantsLaura K. UlepicProgram Management ConsultantChicago, Illinois

Charles RossiAmerican College of PhysiciansPhiladelphia, Pennsylvania

ASCO StaffContent Development and Continuing MedicalEducationAmy SchermerhornAssistant Director, Career Development

Fran StiglianoCME Programs Administrator

Mandy Davis-AitkenProgram Coordinator

Editorial and Publisher ServicesLisa Guttman GreavesDeputy Director, Publications

Lori Alexander, MTPW, ELSAssistant Director, Publications

Fiona HorganEditorial Assistant

ProductionVictoria VaughnProduction Director

Dana MonziProduction Administrator

The American Society of Clinical Oncology acknowledges thatmany other individuals contributed to the development and pro-duction of this publication. Without the dedicated efforts ofthose named and unnamed, this publication would not havebeen possible. Special appreciation goes to CharmaineCummings, RN, PhD, Director of the ASCO Education,Science, and Career Development Department; Deb Whippen,Senior Director of the ASCO Publications Department andExecutive Editor; and Sean McKinney, Director of Self-Assessment Programs at the American College of Physicians,for their collective leadership in making this project a success.

vii