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Contraception for Women and Couples with HIV

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Page 1: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Contraception for Women and Couples with HIV

Page 2: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Introduction

1. HIV/AIDS epidemic disproportionately affects women

2. Role of family planning in alleviating the burden of HIV

3. Reproductive choices and decisions for clients with HIV

4. ARV therapy basics in the context of family planning

5. Ensuring that services meet the needs of clients with HIV

6. Contraceptive options for women and couples with HIV

7. Family planning counselling for clients with HIV

Page 3: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

HIV/AIDS Epidemic Disproportionately Affects Women

Page 4: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

In sub-Saharan Africa,women make up 57% of HIV Cases

Burden on Women

Source: UNAIDS, 2004.

Page 5: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Young Women Are Disproportionately Affected

HIV among 15- to 24-year-olds in sub-Saharan Africa

Source: UNAIDS, 2004.

75% young women

25% young men

Page 6: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Example: Prevalence of HIV in Kenya

5

9

12.911.7 11.8

9.5

5.9

0.4

2.4

7.56.6

8.4 8.8

5.2

0

5

10

15

15-19 20-24 25-29 30-34 35-39 40-44 45-49

Women Men

Source: Kenya DHS, 2003.

Percentage of population by sex and age

Page 7: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Pregnant Women Share Burden

In many countries of southern Africa, one in five pregnant women are HIV infected.

Source: UNAIDS, 2002; CIDA, 2004.

Page 8: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

HIV in Children

Source: UNAIDS, 2004.

Among children, 640,000 new HIV infections worldwide in 2004

Sub-Saharan Africa

Rest of the world

560,000 cases560,000 cases sub-Saharan Africasub-Saharan Africa

Page 9: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Children Orphaned by AIDS

Consequences:

• psychosocial impact

• health risks

• nutritional deficiencies

• economic deprivation

• increase in HIV infection risk

Page 10: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Why Are Women Vulnerable?

Cultural and societal factors• gender inequities• limited opportunities• economic dependence on men• imbalance in sexual relationships

Possible biological factors• large vaginal surface allows more exposure • cervical ectopy may facilitate acquisition

Page 11: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Role of Family Planning in Alleviating the Burden of HIV

Page 12: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Role of FP in HIV Prevention

Support for Support for mother and mother and familyfamily

Prevention Prevention of trans-of trans-mission mission from an HIV-from an HIV-infected infected woman to woman to her infanther infant

Prevention Prevention of of unintended unintended pregnancies pregnancies in HIV-in HIV-infected infected women women

Prevention Prevention of HIV in of HIV in women, women, especially especially young young womenwomen

Source: WHO, 2002.

Family Family planning and planning and

effective use of effective use of contraceptivescontraceptives

Page 13: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

FP Complements Other Programs to Reduce Infant Infections/Deaths

Source: USAID, 2003.

Benefits of integrating family planning and nevirapine programs – annual projection of infections and deaths averted

0

20,000

40,000

60,000

80,000

Nevirapine alone FP plus nevirapine

Child infections averted

Child deaths averted

Page 14: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Benefits of Providing FP Services

For women and couples with HIV:

• improves health/well-being of families and communities– spacing/limiting births

• prevents unintended pregnancies, thus reducing:– number of infants born

infected

– number of future orphans

Page 15: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Unmet Need for Family Planning is High

0

5

10

15

20

25

30

35

40

Ethiopia2000

Kenya2003

Malawi2000

Rwanda2000

Tanzania1999

Uganda2001

Zambia2001

Contraceptive useUnmet need

Percentage of married women of reproductive age

Source: Population Reference Bureau and DHS, 1999 – 2003.

Page 16: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Unmet RH Needs of Young Women

Evidence:• high STI/HIV rates• unintended pregnancy• mortality/morbidity from

unsafe abortion

Causes include lack of:• information/education/communication skills• access to adolescent-friendly RH services

Page 17: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Reproductive Choices and Decisions for Clients with HIV

pregnancy

pregnancychildbearing

childbearing

contraceptioncontraception

Page 18: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Pregnancy in Women with HIV

Positive developments: • ARV therapy improves health/longevity• PMTCT reduces vertical transmission• Wider availability of support and care services

• Does not accelerate disease

• One-third pass HIV to newborn during pregnancy, delivery, and breastfeeding

• Possible increased risk of stillbirth and low birth weight

Page 19: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Clients with HIV:

Reasons to Consider Pregnancy

• Emotional need

• Pressure to have children

• Fear that older children may die

• Concern about infertility

• Reassured by PMTCT

• Optimism about ARV

• Avoid generating suspicions

• Apprehension about disclosing status

Source: Preble, 2003.

Page 20: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Clients with HIV:

Reasons to Avoid Childbearing

• Similar concerns to women without HIV: – economic status– desired family size– ideal spacing

• Concerns about health and quality of life

• Fear of transmitting HIV

• Anxiety about leaving orphans

• Concerns about limited access to help

Page 21: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Access to Information/Services is Key

• Consider reproductive choices

• Plan for the future

• Avoid unintended pregnancy

• Reduce HIV transmission to children

• Reduce transmission to partners

Page 22: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Many Women with HIV Want to Use FP

Source: King, 1995.

0

5

10

15

20

25

Before After

FP services offered

Pregnancyrate among

women with HIV in

Rwandan study

22%

9%

During this period, contraceptive use increased from 16% to 24%.

Page 23: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

ARV Therapy Basics in the Context of Family Planning

Page 24: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

ARV Therapy Overview

• Inhibits replication of the virus

• Slows disease progression; improves quality of life

• Different drugs attack virus at different stages of replication

• Combine three drugs into HAART “cocktail” for best results

decrease decrease viral loadviral load

improveimproveimmuneimmune functionfunction

Page 25: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Classes of ARV Drugs

• NRTIs – Nucleoside reverse transcriptase inhibitors

• NtRTIs – Nucleotide reverse transcriptase inhibitors

• NNRTIs – Non-nucleoside reverse transcriptase inhibitors

• PIs – Protease inhibitors

• Entry inhibitors (other new classes under development)

Page 26: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

HAART Therapy Regimens

=+NR

TI

NNRTINNRTI

NR

TI

PI

ORStandard HAART

Regimen

ARV therapy is complex and should ARV therapy is complex and should only be offered by trained providers.only be offered by trained providers.

Source: WHO, 2002.

Page 27: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Use of ARV Drugs for HIV Prophylaxis

• Prevent mother-to-child transmission (PMTCT)– drug regimen depends on availability, cost,

resistance, possible side effects– reduces vertical transmission by 34% to 50%

• Postexposure prophylaxis (PEP) – start as soon as possible; continue 2 to 4 weeks– multidrug therapy is more effective

• Other uses under study

Source: Dabis, 2000.

Page 28: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Why ARV Clients Benefit from Contraception

• Reduce stress related to unintended pregnancy

• Avoid complicated pregnancy (ARVs can aggravate anaemia and insulin resistance, which are common in pregnancy)

• Have access to wider range of ARV drugs if not pregnant or at risk of pregnancy (some ARVs have potential harmful effects on foetus)

““EFZ should not be given to women of childbearing EFZ should not be given to women of childbearing potential unless effective contraception can be assured.”potential unless effective contraception can be assured.”

– – WHO, 2003WHO, 2003

Page 29: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Ensuring That Services Meet the Needs of Clients with HIV

Page 30: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Choices for Clients with HIV

1. Fertility decision: desire pregnancy?

PregnancyPregnancy desireddesired

NoNo YesYes

2. Informed decision(s):contraceptive method? HIV/STI prevention?

Intended Intended pregnancypregnancy

PregnancyPregnancycounsellingcounselling

ContraceptiveContraceptive counsellingcounselling

Ongoing HIVOngoing HIVcounsellingcounselling

Safe/effectiveSafe/effectivecontraceptioncontraception

3. Treatment decision(s): ARV therapy for self and partner? PMTCT?

PMTCTPMTCT servicesservices

NoNoYesYes

ARVARVtreatmenttreatment

NoNoYesYes

Adapted from: Cates, 2001.

Page 31: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Clients’ Family Planning Rights

All individuals and couples have the right to:

• access information and services

• a variety of methods from which to choose

• make an informed, voluntary choice of contraceptive method

• receive their method of choice

Clients should be supported in exercising their Clients should be supported in exercising their reproductive rights, regardlessreproductive rights, regardless of their HIV status. of their HIV status.

Page 32: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Ensuring Informed Choice

Effective counsellors:

• listen carefully

• empathize with client

• help clients make their own decisions

• are not influenced by personal biases

• provide accurate information

Page 33: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Clients seeking HIV-related services

Why Integrate HIV and FP Services

Share common needs and concerns:• are often sexually active and fertile• are at risk of HIV infection or might be infected • need to know their HIV status • need access to contraceptives

Clients seeking FP services

AND

Page 34: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Why Integrate HIV and FP Services

• more attractive to potential clients– increases access to wider range of services– helps overcome HIV stigma

• opportunities for follow-up and support for drug or method adherence

continued...

Creates programmatic synergies including:

Page 35: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Benefits of Involving Men

• Encourages partner counselling, testing, and disclosure

• Helps women act on prevention messages

• Helps couples make informed decisions on reproductive goals and prevention strategies

• Improves client satisfaction and adoption, continuation, and successful method use

Integrated RH services can provide a valuable Integrated RH services can provide a valuable opportunity to involve men in a meaningful way.opportunity to involve men in a meaningful way.

Page 36: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Contraceptive Options for Women and Couples with HIV

Page 37: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Factors Affecting Decision to Use Contraception

• Health/well-being of self, partner, children

• Access to ARV therapy

• Fears related to disclosing HIV status (rejection, violence, financial loss)

• Knowledge about contraceptives (including cultural myths and misconceptions)

• Gender issues/partner opposition

• Stigma regarding condom use

Page 38: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Factors Affecting Method Choice

Women with HIV may consider:

• safety and effectiveness of the method

• whether it is short-term, long-term, or permanent

• possible side effects

• ease of use

• cost and access to resupply

• effect on breastfeeding (if postpartum)

Page 39: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Factors Affecting Method Choice

continued...

• how it interacts with other medications, including ARVs

• whether it provides protection from HIV/STI transmission and acquisition

• whether partner involvement or negotiation is required

Page 40: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Medical Eligibility for Contraceptives

• evidence-based recommendations

• expert periodic reviews

• 19 contraceptive methods

• variety of medical conditions including HIV infection, presence of AIDS, and use of ARV therapy

Page 41: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Unacceptable health risk

Risks generally outweigh benefits

Benefits generally outweigh risks

No restriction for use

Description

Method not to be used 4

Use of method not usually recommended, unless other methods

are not available/acceptable

3

Generally use the method

2

Use the method under any circumstances

1

When clinical judgment is

availableCategory

WHO Eligibility Criteria

Source: WHO, 2004.

Page 42: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

WHO Eligibility Criteria

Source: WHO, 2004.

4Do not use the method

3

When clinical judgment is limitedCategory

2Use the method

1

Page 43: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

WHO Eligibility Criteria: Examples

Source: WHO, 2004.

current breast cancer

breastfeeding a baby less than 6 weeks postpartum

anaemia

uterine fibroids

Medical Condition/ Characteristic

4

3

2

1

Category

hormonal implants

DMPA

IUD

COCs

Contraceptive Method

Page 44: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Contraceptive Method Options

• barrier methods

• oral contraceptive pills

• injectables

• implants

• intrauterine device (IUD)

• female and male sterilization

• lactational amenorrhoea method (LAM)

• fertility awareness-based methods

Couples with HIV have a wide range of methods from Couples with HIV have a wide range of methods from which to choose.which to choose.

Page 45: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Pregnancy Rates by Method

Source: Hatcher, 2004.

Oral contraceptives

Percentage of women pregnant in first year of use

Rate during typical use

Rate during perfect use

Female condom

Female sterilization

Norplant

Depo-Provera

Spermicides

Diaphragm w/spermicides

Male condom

IUD (TCu-380A)

0 10 15 20 255 30

Page 46: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Condoms

• Prevent both pregnancy and STIs/HIV when used consistently and correctly

• In real-life situations, correct and consistent use may be difficult to achieve

Source: Hatcher, 2004.

21%15%typical use

5%2%perfect use

Male FemalePregnancy rates:

Page 47: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Condoms Prevent HIV/STI Transmission

• Typical use: 80% reduction in HIV incidence

• Consistent use: infection rate less than 1% per year in discordant couples

• With infected partner: inconsistent condom use is as risky as using no condom at all

• Prevents STIs transmitted through body fluids– less effective for skin-to-skin contact STIs

Source: Weller, 2003; Deschamps, 1996; Hatcher, 2004.

Page 48: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Condom Use by Clients with HIV

• Prevent STI/HIV transmission

• Prevent possible superinfection with a different HIV strain

• Are less effective in typical use than some other methods for pregnancy prevention

• Consistent and correct use should be encouraged

WHO Eligibility CriteriaWHO Eligibility Criteria

ConditionCondition CategoryCategory

HIV-HIV-infectedinfected 11

AIDSAIDS 11

ARV ARV TherapyTherapy 11

Source: WHO, 2004.

Page 49: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Why Encourage Dual Method Use

Reduces:

• risk of unintended pregnancy

• transmission of HIV between partners

• risk of acquiring or transmitting other STIs

Use condoms to protect against HIV/STIs and another Use condoms to protect against HIV/STIs and another method to prevent pregnancy.method to prevent pregnancy.

Dual method use may not be easy to achieve.Dual method use may not be easy to achieve.

Page 50: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Counselling about Dual Method Use

Encourage clients to consider:

• limitations of a single-method approach

• their individual risk of pregnancy

• whether partners have HIV or other STIs

• the negative consequences that may result

Users of more effective methods may be less likely to Users of more effective methods may be less likely to use condoms.use condoms.

Page 51: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Counselling about Dual Method Use

continued...

Teach clients:

• to negotiate condom use

• how to use condoms

• importance of using condoms consistently with all partners

Encourage dual method use for all clients with HIV Encourage dual method use for all clients with HIV who wish to protect themselves.who wish to protect themselves.

Page 52: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Hormonal Contraceptives

• Combined oral contraceptive pills (COCs)

• Progestin-only oral contraceptive pills (POPs)

• Injectables (Depo-Provera/DMPA)

• Implants (Norplant, Jadelle, Implanon)

Page 53: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Hormonal Methods:

Appropriate for Women with HIV

• Very effective

• Easy to use

• Suitable for short- or long-term use

• Reversible

• Non-contraceptive health benefits

• Serious complications extremely rare

Page 54: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Overview: Theoretical Concerns About Hormonal Methods

For women with HIV:

• ARVs may reduce method effectiveness or increase side effects

• contraceptives may affect ARV efficacy

• hormonal methods may possibly affect– infectivity

– disease progression

More research is needed before reviewing clinical practices.More research is needed before reviewing clinical practices.

? ???

?

4

Page 55: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

How ARVs Interact with COCs

• May cause an increase or decrease of hormone levels

• Some ARVs speed up liver metabolism and could lower oestrogen blood levels, may reduce method effectiveness

• Not all ARV classes interact with contraceptive hormones (e.g., NRTIs)

Page 56: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Interactions between COCs and NNRTIs

Non-nucleoside reverse Non-nucleoside reverse transcriptase inhibitorstranscriptase inhibitors

Contraceptive Contraceptive hormone levels hormone levels

in bloodin blood

ARV levelsARV levels in blood in blood

Nevirapine Nevirapine (NVP)(NVP) No changeNo change

Efavirenz Efavirenz (EVF or EFZ) (EVF or EFZ) No changeNo change

Delavirdine Delavirdine (DLV)(DLV) ? ? No dataNo data

teratogen

Source: WHO, 2004; Mildvan, 2002.

Page 57: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Interactions between COCs and PIs

Source: WHO, 2004; Ouellet, 1998; GlaxoSmithKline, 2002.

Protease inhibitorsProtease inhibitorsContraceptive Contraceptive

hormone levels hormone levels in bloodin blood

ARV levels ARV levels in bloodin blood

Nelfinavir Nelfinavir (NFV)(NFV) No dataNo data

Ritonavir Ritonavir (RTV)(RTV) No dataNo data

Lopinavir Lopinavir (LPV)(LPV)/ / Ritonavir Ritonavir (RTV)(RTV)

No dataNo data

Atazanavir Atazanavir (ATV)(ATV) No dataNo data

Amprenavir Amprenavir (APV)(APV)

Indinavir Indinavir (IDV)(IDV) No dataNo data

Saquinavir Saquinavir (SQV)(SQV) No dataNo data No changeNo change

Page 58: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Clinical Significance of COC/ARV Interaction Is Unknown

• Not clear that effectiveness of contraceptives is affected by ARVs

• No studies of clinical outcomes completed (i.e., pregnancy rates, ovulation indicators)

• No data on interaction between ARVs and hormonal contraceptives other than COCs

More research is needed before reviewing clinical practices.More research is needed before reviewing clinical practices.

? ???

?

4

Page 59: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Hormonal Use: Increases Risk of Cervical Infection

DMPADMPA COCsCOCs

Increased risk of chlamydiaIncreased risk of chlamydia 3.13.1 2.2*2.2*

Increased risk of cervicitisIncreased risk of cervicitis 1.61.6 2.3 2.3

Source: Lavreys, 2004.

* not statistically significant when adjusted for demographic factors

Page 60: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Hormonal Use:

May Increase HIV Shedding

• HIV shedding may increase risk of HIV transmission to partner

• In one study, modest increase in cervical shedding of HIV-infected cells but no free virus

• Impact on infectivity is uncertain

? ???

?

4

Page 61: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Relationships Require Further Research

Cervical STI Cervical STI infections may also infections may also increase cervical increase cervical shedding of HIVshedding of HIV

More HIV virus More HIV virus may increase may increase risk of transmis-risk of transmis-sion to partnersion to partner

Using hormonal Using hormonal contraceptives contraceptives may increase: may increase: • risk of acquiring risk of acquiring

cervical STIs cervical STIs • cervical shedding cervical shedding

of HIV virusof HIV virus

More research is needed before reviewing clinical practices.More research is needed before reviewing clinical practices.

? ???

?

4

Page 62: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Hormonal Use:Theoretically May Affect Disease Progression

Use of hormonal contraceptives near the time of HIV acquisition is associated with:

• higher viral load set point (indicator of disease progression)

• infection with multiple subtypes of HIV, resulting in faster CD4 decline

Source: Lavreys, 2004; Sagar, 2003.

More research is needed before reviewing clinical practices.More research is needed before reviewing clinical practices.

? ???

?

4

Page 63: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

OC Use by Women with HIV

• Women with HIV/AIDS can use without restrictions

• May not be best choice for women on ARVs

• Using low-dose COC is reasonable if taken correctly by women on ARVs

• Dual method use should be encouraged

WHO Eligibility CriteriaWHO Eligibility Criteria

ConditionCondition CategoryCategory

HIV-HIV-infectedinfected 11

AIDSAIDS 11

ARV ARV TherapyTherapy 2

Source: WHO, 2004.

Page 64: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

ECP Use by Women with HIV

• Use to prevent pregnancy after unprotected intercourse – progestin-only and combined oestrogen-progestin regimens

(reduce risk of pregnancy by 75%)

– start as soon as possible; counsel to adopt regular method

• Use if regular method was used incorrectly, failed, or was not used

• Safe for all women (including women with HIV/AIDS and taking ARV drugs)

There is no evidence to justify changes to emergency There is no evidence to justify changes to emergency contraceptive pill regimens for ARV clients.contraceptive pill regimens for ARV clients. Source: Hatcher, 2004; WHO, 2004.

Page 65: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Injectable Use by Women with HIV

• Women with HIV/AIDS can use without restrictions

• Nevirapine reduces blood progestin level by ~20%

• DMPA dose provides wide margin of effectiveness

• Encourage to receive injections on time

• Dual method use should be encouraged

WHO Eligibility CriteriaWHO Eligibility Criteria

ConditionCondition CategoryCategory

HIV-HIV-infectedinfected 11

AIDSAIDS 11

ARV ARV TherapyTherapy 2

Source: WHO, 2004; Mildvan, 2002; Said, 1986.

Page 66: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Implant Use by Women with HIV

• Women with HIV/AIDS can use without restrictions

• Nevirapine reduces blood progestin level by ~20%

• Implants provide consistent dose of hormone over time

• No evidence that lower dose may be less effective

• Dual method use should be encouraged

WHO Eligibility CriteriaWHO Eligibility Criteria

ConditionCondition CategoryCategory

HIV-HIV-infectedinfected 11

AIDSAIDS 11

ARV ARV TherapyTherapy 2

Source: WHO, 2004; Mildvan, 2002.

Page 67: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Hormonal Use and HIV:

What Providers Should Do

• Counsel clients that some ARV drugs may reduce the efficacy of some hormonal contraceptives (e.g., COCs)

• When there is a choice, prescribe ARV drugs that do not interact with hormonal methods

• Encourage correct and consistent use of contraceptive method

• Keep abreast of updates to guidelines

Page 68: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Intrauterine Device

• Highly effective, long-term, reversible method

• Remains in place up to 12 years

• Almost 100 percent effective

• Has no effect on fertility when used by nulliparous women

• Attractive method for women with HIV who desire very reliable pregnancy protection

Copper T-380A

Source: Hatcher, 2004.

Page 69: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

IUDs Safe for Women with HIV

Source: Morrison, 2001.

Percentage of women in Kenyan study

Little difference in complications between IUD acceptors with and without HIV.

Page 70: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

IUD Use Does Not Increase HIV Transmission

Theoretical concern:

• IUD use by women with HIV may increase risk of transmission to partner

Research has found:

• no post-insertion increase in cervical shedding

• no increased risk of partner exposure to higher dose of virus

Source: Richardson, 1999.

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Page 71: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

IUD Use by Women with HIV

• Safe for majority of women with HIV

• Initiation not recommended if woman has AIDS and is not on ARV therapy

• Dual method use should be encouraged

WHO Eligibility CriteriaWHO Eligibility Criteria

ConditionConditionCategoryCategory

InitiateInitiate ContinueContinue

HIV-infectedHIV-infected 2 2AIDSAIDS(without ARVs)(without ARVs) 3 2

ARV ARV TherapyTherapy(clinically well)(clinically well)

2 2

Source: WHO, 2004.

Page 72: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Spermicides

• Provide limited protectionwith pregnancy rates: – 18% perfect use – 29% typical use

• Provide no STI protection

• May increase risk of HIV (with frequent use)

Source: Hatcher, 2004; Wilkinson, 2002; WHO, 2002; Van Damme 2002.

Page 73: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Diaphragms

• Diaphragm used with spermicide– 6% failure rate in perfect use– 20% failure rate in typical use

• May offer limited protection from STI/HIV– blocks cervix as entry point for

gonorrhoea, chlamydia, and HIV– studies are under way

Source: Hatcher, 2004; Moench, 2001; Hu, 2000.

Page 74: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Spermicide/Diaphragm:

Use By Women with HIV

• Use not recommended

• May increase the risk of HIV transmission

• If a woman desires reliable pregnancy protection, encourage consideration of other methods

• Encourage dual method use

Source: WHO, 2004; Gottlieb, 2004.

Page 75: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Surgical Sterilization

• Good for couples who want no more children

• Safe, simple surgical procedure

• Considered permanent

• Very effective; pregnancy rates:

– Female: 0.5% after one year, increasing to 1.85% over ten years

– Male: 0.1% - 0.15% (possibly higher)

Female

Source: Hatcher, 2004.

Male

Page 76: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

• No medical reasons to deny sterilization to clients with HIV

• Procedure may be delayed in event of acute HIV-related infection

• Encourage condom use

Sterilization Use by Clients with HIV

Source: WHO, 2004.

Page 77: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Lactational Amenorrhoea Method

• Temporary contraceptive option

• Used by postpartum women who:– are less than six months

postpartum– are fully or nearly fully

breastfeeding – have no menses

• Safe, convenient, effective

Source: Hatcher, 2004.

Page 78: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

LAM Use by Women with HIV

• Advise that children can become infected– risk of acquisition through breast milk ~16%

• Exclusive breastfeeding during first six months may reduce risk of acquisition by infant (compared to mixed feeding)

• Exclusive use of formula or other substitutes eliminates risk of transmission through breast milk (often not possible)

Source: WHO, 2004; Nduati, 2000; De Cock, 2000.

Page 79: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Fertility Awareness-based Methods

• Identify fertile days of the menstrual cycle– observe fertility signs – monitor cycle days (calendar method)

• Can be used in combination with abstinence or barrier methods during the fertile time

• Pregnancy rate: – perfect use 2% to 5%; typical use 12% to 22%

Counsel clients with HIV who do not want more Counsel clients with HIV who do not want more children about more reliable methods.children about more reliable methods.

Source: Hatcher, 2004.

Page 80: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

FAB Methods Use by Women with HIV

Women who have HIV with/without AIDS and those on ARV therapy:

• can use without restrictions (calendar method relies on regular menstrual cycles)

• should be encouraged to use condoms

Source: WHO, 2004.

Page 81: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Summary of Contraceptive Choices

• Use two methods concurrently (condoms plus another contraceptive method)

• Use one method and understand its limitations (prevent pregnancy versus prevent transmission) – effective pregnancy prevention but no STI/HIV protection

– condoms protect from STIs/HIV but typically less effective preventing pregnancy than other methods

• Use no method and abstain from sexual intercourse

Page 82: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Family Planning Counselling for Clients with HIV

Page 83: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Essential Counselling Skills

• Be sensitive to circumstances of women and couples with HIV

• Respect clients’ rights

• Ensure that all women, regardless of HIV status, are free to make informed choices about pregnancy and contraception

• Assure privacy and confidentiality

Page 84: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Essential Counselling Skills

continued...

• Help clients consider how HIV affects individual circumstances and needs

• Tailor counselling session to needs of client

• Facilitate partner involvement and offer partner counselling

• Provide comprehensive, factual, unbiased information

• Support client’s FP decisions, even if you disagree

Avoid any type of coercion.Avoid any type of coercion.

Page 85: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Counselling about Pregnancy

Providers should discuss:

• pregnancy does not accelerate HIV disease

• condom use to prevent STI/HIV transmission between partners

• risks/rates of mother-to-child transmission

• ARV drugs reduce transmission at delivery

Page 86: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Counselling about Pregnancy

continued...

• artificial feeding or exclusive breastfeeding reduces postpartum transmission

• implications of rearing a child with HIV

• availability of family support

• location/logistics of care and treatment

Page 87: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Counselling about Contraception

Providers should discuss:

• characteristics of contraceptive methods

• possible side effects and complications

• method effectiveness and ability to use correctly

• implications/drug interactions for women with HIV who choose hormonal contraception and: – are on ARV therapy– are taking rifampicin (co-infection with TB)

Page 88: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Counselling about Contraception

continued...

• limitations of methods with regard to prevention of pregnancy and STI/HIV transmission

• advantages of dual protection, including dual method use

• partner’s willingness to use condoms, condom negotiation strategies

• when to return and where to access services

Page 89: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

ARVs and Hormonal Contraception

For women using ARV drugs and hormonal contraception, providers should discuss:

• need to take pills on schedule

• need to return for DMPA injection on time

• possibility of using condoms to provide additional protection from pregnancy

(in case hormonal contraceptive effectiveness is compromised by ARVs)

Page 90: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Additional Counselling Topics

• Importance of knowing partner’s HIV status – encourage partner testing if status is unknown

– discuss health implications/prevention strategies for discordant/concordant couples

• Considerations in disclosing HIV status– risk of abandonment

– violence

– loss of financial support

Page 91: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

• Discuss available support systems: – family– community– social

– legal– nutritional– child health

continued...

• Offer referrals to other RH services as needed: – STI management and treatment – postpartum, postabortion, antenatal care– HIV care and treatment

Additional Counselling Topics

Page 92: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Program Requirements

To address contraceptive needs of clients with HIV, programs should:

• ensure providers have necessary skills

• ensure availability of FP commodities/supplies

• provide adequate counselling and storage facilities

• ensure supervision/management support

• have referral system in place

Page 93: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Role of Contraceptive Services

Contraceptive services can:

• be sources of information and methods

• assist with preventing HIV transmission

• help clients consider effect of HIV on family health

• assist clients to make informed RH choices

Page 94: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Conclusion

With very limited exceptions, almost any method of With very limited exceptions, almost any method of contraception can be used by clients with HIV.contraception can be used by clients with HIV.

Page 95: Contraception for Women and Couples with HIV. Introduction 1.HIV/AIDS epidemic disproportionately affects women 2.Role of family planning in alleviating

Produced by Family Health International in collaboration with the ACQUIRE Project.

Financial support provided by the United States Agency for International Development, Regional Economic Development Services Office for

East and Southern Africa (REDSO/ESA).