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8/19/2016 1 Contemporary Psychiatric-Mental Health Nursing Third Edition CHAPTER Contemporary Psychiatric-Mental Health Nursing, Third Edition Carol Ren Kneisl • Eileen Trigoboff 7 The Science of Psychopharmacology Contemporary Psychiatric-Mental Health Nursing, Third Edition Carol Ren Kneisl • Eileen Trigoboff Figure 7-1 Important Dates in the Treatment of Mental Disorder with Psychopharmacology. Photo source top to bottom by column: Philosophical Library; Smock, Timothy K., Physiological Psychology: A Neuroscience Approach, 1st Ed., ©1999. Reprinted and electronically reproduced by permission of Pearson Education, Inc., Upper Saddle River, New Jersey; Everett Collection; Shutterstock; Eileen Trigoboff; Shutterstock; Eileen Trigoboff; Pearson; Pearson; Pearson; Pearson; suravid/Shutterstock. Contemporary Psychiatric-Mental Health Nursing, Third Edition Carol Ren Kneisl • Eileen Trigoboff Figure 7-1 (continued) Important Dates in the Treatment of Mental Disorder with Psychopharmacology. Photo source top to bottom by column: Philosophical Library; Smock, Timothy K., Physiological Psychology: A Neuroscience Approach, 1st Ed., ©1999. Reprinted and electronically reproduced by permission of Pearson Education, Inc., Upper Saddle River, New Jersey; Everett Collection; Shutterstock; Eileen Trigoboff; Shutterstock; Eileen Trigoboff; Pearson; Pearson; Pearson; Pearson; suravid/Shutterstock.

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Page 1: Contemporary Psychiatric-Mental Health Nursing · Contemporary Psychiatric-Mental Health Nursing Third Edition CHAPTER Contemporary Psychiatric-Mental Health Nursing, Third Edition

8/19/2016

1

Contemporary Psychiatric-MentalHealth Nursing

Third Edition

CHAPTER

Contemporary Psychiatric-Mental Health Nursing, Third EditionCarol Ren Kneisl • Eileen Trigoboff

7The Science ofPsychopharmacology

Contemporary Psychiatric-Mental Health Nursing, Third EditionCarol Ren Kneisl • Eileen Trigoboff

Figure 7-1 Important Dates in the Treatment of Mental Disorder with Psychopharmacology. Photo source top to bottom by column: Philosophical Library; Smock, Timothy K., Physiological Psychology: A Neuroscience Approach, 1st Ed., ©1999. Reprinted and electronically reproduced by permission of Pearson Education, Inc., Upper Saddle River, New Jersey; Everett Collection; Shutterstock; Eileen Trigoboff; Shutterstock; Eileen Trigoboff; Pearson; Pearson; Pearson; Pearson; suravid/Shutterstock.

Contemporary Psychiatric-Mental Health Nursing, Third EditionCarol Ren Kneisl • Eileen Trigoboff

Figure 7-1 (continued) Important Dates in the Treatment of Mental Disorder with Psychopharmacology. Photo source top to bottom by column: Philosophical Library; Smock, Timothy K., Physiological Psychology: A Neuroscience Approach, 1st Ed., ©1999. Reprinted and electronically reproduced by permission of Pearson Education, Inc., Upper Saddle River, New Jersey; Everett Collection; Shutterstock; Eileen Trigoboff; Shutterstock; Eileen Trigoboff; Pearson; Pearson; Pearson; Pearson; suravid/Shutterstock.

Page 2: Contemporary Psychiatric-Mental Health Nursing · Contemporary Psychiatric-Mental Health Nursing Third Edition CHAPTER Contemporary Psychiatric-Mental Health Nursing, Third Edition

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Contemporary Psychiatric-Mental Health Nursing, Third EditionCarol Ren Kneisl • Eileen Trigoboff

Figure 7-1 (continued) Important Dates in the Treatment of Mental Disorder with Psychopharmacology. Photo source top to bottom by column: Philosophical Library; Smock, Timothy K., Physiological Psychology: A Neuroscience Approach, 1st Ed., ©1999. Reprinted and electronically reproduced by permission of Pearson Education, Inc., Upper Saddle River, New Jersey; Everett Collection; Shutterstock; Eileen Trigoboff; Shutterstock; Eileen Trigoboff; Pearson; Pearson; Pearson; Pearson; suravid/Shutterstock.

Contemporary Psychiatric-Mental Health Nursing, Third EditionCarol Ren Kneisl • Eileen Trigoboff

Figure 7-1 (continued) Important Dates in the Treatment of Mental Disorder with Psychopharmacology. Photo source top to bottom by column: Philosophical Library; Smock, Timothy K., Physiological Psychology: A Neuroscience Approach, 1st Ed., ©1999. Reprinted and electronically reproduced by permission of Pearson Education, Inc., Upper Saddle River, New Jersey; Everett Collection; Shutterstock; Eileen Trigoboff; Shutterstock; Eileen Trigoboff; Pearson; Pearson; Pearson; Pearson; suravid/Shutterstock.

Contemporary Psychiatric-Mental Health Nursing, Third EditionCarol Ren Kneisl • Eileen Trigoboff

Figure 7-2 The great success of biologic psychiatry. This graph illustrates the dramatic decrease in psychiatric inpatient numbers since the inception of psychopharmacology.

Page 3: Contemporary Psychiatric-Mental Health Nursing · Contemporary Psychiatric-Mental Health Nursing Third Edition CHAPTER Contemporary Psychiatric-Mental Health Nursing, Third Edition

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Contemporary Psychiatric-Mental Health Nursing, Third EditionCarol Ren Kneisl • Eileen Trigoboff

Table 7-1 Medications and Their Cross-Diagnostic Uses

Contemporary Psychiatric-Mental Health Nursing, Third EditionCarol Ren Kneisl • Eileen Trigoboff

Box 7-1 CATIE Study Summary

Contemporary Psychiatric-Mental Health Nursing, Third EditionCarol Ren Kneisl • Eileen Trigoboff

Table 7-2 Antipsychotic Medications

Page 4: Contemporary Psychiatric-Mental Health Nursing · Contemporary Psychiatric-Mental Health Nursing Third Edition CHAPTER Contemporary Psychiatric-Mental Health Nursing, Third Edition

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Contemporary Psychiatric-Mental Health Nursing, Third EditionCarol Ren Kneisl • Eileen Trigoboff

Table 7-2 (continued) Antipsychotic Medications

Contemporary Psychiatric-Mental Health Nursing, Third EditionCarol Ren Kneisl • Eileen Trigoboff

Table 7-3 Antidepressant Medications

Contemporary Psychiatric-Mental Health Nursing, Third EditionCarol Ren Kneisl • Eileen Trigoboff

Figure 7-3 Structure of the synapse. The synapse on this slide has many specialized characteristics. The electron micrograph shows the vesicles containing the synaptic transmitter, the abundance of mitochondria necessary for energy production, and the abundance of protein in the presynaptic and postsynaptic densities. Photo courtesy of Photo Researchers, Inc., Don W. Fawcett.

Page 5: Contemporary Psychiatric-Mental Health Nursing · Contemporary Psychiatric-Mental Health Nursing Third Edition CHAPTER Contemporary Psychiatric-Mental Health Nursing, Third Edition

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Contemporary Psychiatric-Mental Health Nursing, Third EditionCarol Ren Kneisl • Eileen Trigoboff

Figure 7-3 Structure of the synapse. This slide shows incoming axons (purple) contacting dendrites (yellow) with nonneural cells nearby (green). Photo courtesy of Photo Researchers, Inc.

Contemporary Psychiatric-Mental Health Nursing, Third EditionCarol Ren Kneisl • Eileen Trigoboff

Figure 7-4 Serotonin neurotransmission. (a) A highly schematic model of normal serotonin (5-HT) neurotransmission. (b) In depression, there may be a shortage of 5-HT in the synapse. (c) The action of an antidepressant medication blocking 5-HT reabsorption (reuptake).

Contemporary Psychiatric-Mental Health Nursing, Third EditionCarol Ren Kneisl • Eileen Trigoboff

Table 7-4 Generic and Trade Names of Benzodiazepines and Nonbenzodiazepines

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Contemporary Psychiatric-Mental Health Nursing, Third EditionCarol Ren Kneisl • Eileen Trigoboff

Table 7-4 (continued) Generic and Trade Names of Benzodiazepines and Nonbenzodiazepines

Contemporary Psychiatric-Mental Health Nursing, Third EditionCarol Ren Kneisl • Eileen Trigoboff

Table 7-4 (continued) Generic and Trade Names of Benzodiazepines and Nonbenzodiazepines