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Receptor tyrosine kinase identification/quantification using LC/MSMS MS2plex applied to oncogenic recpetors

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Rational for proteomic quantification (MS2plex®) in cancer management

Tumor heterogeneity is now well demonstrated and a critical issue (between/within patients)

This impairs the rational selection a therapeutic strategy

Identification of subtypes is achieved by Molecular Biology (not directly linked to protein expression/function) and through antibodies (with specificity and throughput issues)

MS2plex®, new alternative to allow the measurement of up to 21 different markers in a single run

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3 - 06/02/2017

Proteomic quantification (MS2plex®*) principle

*Exclusive Technologie developed by Terasaki Tetsuya, Tohoku University, Sendai, Japan

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4 - 06/02/2017

Membrane proteins in plasma membrane fraction expression levels of tumor tissues useful for an appropriate drug selection for the individual treatment of brain tumor

Patient having an anaplastic meningioma with metastatic lesion remaining after surgery & radiotherapy

* Platelet derived growth factor receptor

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Biomarker applications: identifying accurate target receptor (clinical study case)

NeuropathologyandAppliedNeurobiology(2012),38,105–110

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5 - 06/02/2017

Biomarker applications: identifying accurate target receptor (clinical study case)

Sunitinib (marketed as Sutent), an oral SMI of multi-targeted receptor tyrosine kinase approved for the treatment of renal cell carcinoma used as adjuvant chemotherapy

NeuropathologyandAppliedNeurobiology(2012),38,105–110

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Solutions

Central lab to quantify TKR & other membrane protein in your samples

Supplyer of kit ready-to-use

Prerequisits: mg of biopsis (frozen samples) Sensitivity in fmol range

Thank you for your attention!

For additional details, we remain at your entire service

Take a chance to visit our website:

bertinpharma.com

Thank you for your attention!

For additional details, we remain at your entire service

Take a chance to visit our website: