conference of the north american section of ishr€¦ · hemal patel, university of california, san...

36th Annual

Conference of the North American Section of ISHR

New Orleans, Louisiana

Hilton Riverside Hotel May 30 - June 2

2017

International Society for Heart Research North American Section

2

XXXVI North American Section

TABLE OF CONTENTS

PROGRAM AGENDA 3 - 13

TUESDAY, MAY 30th

3

WEDNESDAY, MAY 31st

4

THURSDAY, JUNE 1

st 8

FRIDAY, JUNE 2

nd 12

3

TUESDAY

30th

may

TIME ROOM & LOCATION ACTIVITY

8:00am Registration Desk ECI Registration opens.

8:30am - Chart Room ECI Symposium

10:30am - Quarterdeck Room Coffee Break.

10:45am - Chart Room Career Development Panel

12:00pm -

2:00pm

Drago’s Seafood

Restaurant

ECI Luncheon

2:30pm -

4:00pm

Chart Room Young Investigator Competition (Junior Science)

4:00pm -

5:30pm

Chart Room Young Investigator Competition (Senior Science)

6:00pm Chart Room Opening Keynote Lecture Chair: Jeffery D. Molkentin, Cincinnati Children’s Hospital Medical Center

6:00pm Eric Olson, University of Texas, Southwestern Medical Center “The Molecules and Mechanisms of Heart Development, Disease and Regeneration”

7:15pm -

9:00pm

River/Port/Starboard

Room

Welcome Reception and Poster Session I

4

WEDNESDAY

31st

may


7:30am Registration Desk Registration

8:00am River/Port/Starboard

Room

Research Achievement Award: Chair: Gary Lopaschuk, University of Alberta Co-chair: Metin Avkiran, King’s College London

8:00am Rong Tian, University of Washington TBD


Room

Session 1: Post-Translational Modification of the Cardiac Proteome. Chair: Traci T. Goodchild, Louisiana State University Health Sciences Center, New Orleans Co-chair: Frederica del Monte, Beth Isreal Deaconess Medical Center - Harvard, Boston

9:00am 1. PROTEIN DYNAMICS IN HEART Peipei Ping, University of California, Los Angeles

9:30am 2. O-GLCNACYLATION IN HEART FAILURE Steven Jones, University of Louisville

10:00am 3. ACETYLATION OF TRANSCRIPTION FACTORS IN THE HEART Ravichandran Ramasamy, New York University

10:30am 4: S-NITROSYLATION: INSIGHTS FROM THE FEMALE HEART Mark Kohr, John Hopkins University

9:00am Chart Room Session 2: New Targets for Heart Failure Chair: Lea Delbridge, University of Melbourne, Australia Co-chair: Livia Hool, University of Western Australia

9:00am 1. EPIGENETIC CONTROL OF HEART FAILURE Joseph A. Hill, University of Texas Southwestern

9:30am 2. TBA

10:00am 3. AMINO ACID CATABOLISM REPROGRAMMING IN HEART FAILURE Yibin Wang, University of California, Los Angeles

10:30am 4. TARGETING MITOCHONDRIAL IRON Hossein Ardehali, Northwestern University

10:30am -11:00am

Quarterdeck Room Coffee Break.

5

WEDNESDAY

31st

may



Room

Session 3: Stem Cells and Stem Cell Derived Factors Chair: Thomas Eschenhagen, Medical Center Hamburg-Eppendorf, Germany Co-Chair: Steven Houser, Temple University, Philadelphia

11:00am 1. EXOSOMES FOR HEART DISEASE Eduardo Marban, Cedars-Sinai, Los Angeles

11:30am 2. TBA

12:00pm 3. STEM CELL THERAPY FOR HEART FAILURE Roberto Bolli, University of Louisville

12:30pm 4. IPSCS FOR PRECISION CARDIOVASCULAR MEDICINE Joseph Wu, Stanford Medicine

11:00am Chart Room Session 4: Mitochondrial Quality Control in Health and Disease Chair: Tish Murphy, National Institutes of Health Co-Chair: Christopher P. Baines, University of Missouri

11:00am 1. MITOCHONDRIAL DYNAMICS Gerald Dorn, Washington University, St. Louis

11:30am 2. MITOCHONDRIAL BIOGENESIS Dan Kelly, Sanford Burnham Prebys Medical Discovery Institute

12:00pm 3. NON-CANNONICAL MITOPHAGIC PATHWAYS Asa Gustafsson, University of California, San Diego

12:30pm 4. MITOCHONDRIAL QUALITY CONTROL Richard Youle, National Institutes of Health

12:30pm- Quarterdeck Room Lunch and Poster Session I

2:00pm River/Port/Starboard

Room

Session 5: Novel Targets in Cell Death and Survival Chair: Evripidis Gavathiotis, Albert Einstein College of Medicine Co-chair: Lorrie Kirshenbaum, University of Manitoba, Canada

2:00pm 1. MITOCHONDRIAL PERMEABILITY TRANSITION-MOLECULAR MAKEUP AND THERAPEUTIC TARGET Paolo Bernardi, University of Padova, Italy

6

WEDNESDAY

31st

may


2:30pm 2. NECROTIC CELL DEATH AND BIOLOGY OF INFLAMMATION Michael Lotze, University of Pittsburgh

3:00pm 3. NOVEL THERAPEUTIC APPROACHES IN CELL DEATH Richard Kitsis, Albert Einstein College of Medicine

3:30pm 4. REDOX SIGNALING IN CARDIAC RENEWAL Hesham Sadek, University of Texas Southwestern

2:00pm Chart Room Session 6: Signaling Mechanisms in Heart Failure Chair: Imran Mungrue, Louisiana State University Health Sciences Center, New Orleans Co-chair: TBA

2:00pm 1. DJ-1 SIGNALING IN HEART FAILURE John W. Calvert, Emory University

2:30pm 2. CAM KINASE II REGULATION OF INFLAMMATION AND FIBROSIS Joan Heller Brown, University of California, San Diego

3:00pm 3. MACROPHAGE MEDIATED SIGNALING Sumanth Prabhu, University of Alabama, Birmingham

3:30pm 4. RELAXIN SIGNALING AND MYOCARDIAL PROTECTION Fadi Salloum, Virginia Commonwealth University

3:30pm - Quarterdeck Room Coffee Break.


Room

Session 7: Stem Cell Mediated Myocardial Regeneration Chair: TBA Co-chair: Doris Taylor, Texas Heart Institute Timothy J. Kamp, University of Wisconsin - Madison

4:00pm 1. C-KIT STEM CELL MEDIATED MYOCARDIAL REPAIR Jop Van Berlo, University of Minnesota

4:30pm 2. PLOIDY: WE ARE SO MUCH MORE THAN DIPLOID Mark A. Sussman, San Diego State University

5:00pm 3. MESENCHYMAL STEM CELLS Joshua Hare, University of Miami Health System

5:30pm 4. LINEAGE TRACING OF CARDIAC PROGENITOR CELLS Jeff Molkentin, Cincinnati Children’s Hospital Medical Center

7

WEDNESDAY

31st

may


4:00pm Charter Room Session 8: Cardiac Myofilament Proteins Chair: Pieter DeTombe, Loyola University, Chicago Co-Chair: Jill Tardiff, University of Arizona

4:00pm 1. DIASTOLIC DYSFUNCTION IN INHERITED AND ACQUIRED CARDIOMYOPATHIES Richard Moss, University of Wisconsin, Madison

4:30pm 2. TITIN AND CARDIOMYOPATHIES Henk Granzier, University of Arizona

5:00pm 3. S-GLUTATHIONYLATION OF MYOSIN BINDING PROTEIN C Michelle Monasky, Case Western Reserve University

5:30pm 4. REGULATION OF TROPONIN IN HEAT FAILURE Jian-Ping Jin, Wayne State University, Detroit

5:30pm - Quarterdeck Room Reception and Poster Session II.

7:30pm -

9:30pm

Napoleon House ECI Social Event

8

THURSDAY

1st

june


7:30am Registration Desk Registration


Room

Peter Harris Award Lecture Chair: David Eisner, University of Manchester, UK Co-chair: TBA

8:00am John Solaro, University of Illinois, Chicago “Sarcomeres as Hubs of Signaling in the Heart”


Room

Session 9: Proteotoxicity and Cardiovascular Disease Chair: Johannes Backs, Heidelberg University Hospital, Germany Co-Chair: Suresh Palaniyandi, Henry Ford Hospital, Detroit Monte Willis, University of North Caolina

9:00am 1. PROTEIN AGGREGATES AND AUTOPHAGY IN HEART FAILURE Jeffrey Robbins, Cincinnati Children’s Hospital Medical Center

9:30am 2. AMYLOID CARDIOMYOPATHIES Ronglih Liao, Harvard University, Boston

10:00am 3. PROTEIN DEGRADATION IN HEART FAILURE X.J. Wang, University of South Dakota

10:30am 4. PTMS AND CARDIOVASCULAR DISEASE Jenny Van Eyk, Cedars-Sinai, Los Angeles

9:00am Chart Room Session 10: Calcium Regulation in Heart Failure Chair: Salvatore Pepe, Murdoch Children’s Research Institute, Australia Co-chair: Don Bers, University of California, Davis

9:00am 1. CAMKII SIGNALING Mark Anderson, Johns Hopkins University

9:30am 2. TBA

10:00am 3. DYNAMIC MITOCHONDRIAL CA2+ AND ROS SIGNALING Shey-Shing Sheu , Thomas Jefferson University

10:30am 4. MOLECULAR REGULATION OF MITOCHONDRIAL CA2+ IN DISEASE John Elrod, Temple University, Philadelphia

9

THURSDAY

1st

june


10:30am- Quarterdeck Room Breakfast.


Room

Session 11: Epigenetic Regulation in Cardiovascular Disease Chair: Thomas Vondriska, University of California, Los Angeles Co-chair: Susan Howlett, Dalhousie University, Canada

11:00am 1. CHROMATIN BIOLOGY IN CARDIAC STRESS Sarah Franklin, University of Utah

11:30am 2. GENOME WIDE MAPPING OF CARDIAC AND FIBROBLAST ENHANCERS Izhak Kehat, Technion - Israel Institute of Technology, Israel

12:00pm 3. HEMATOPOIETIC CELL REGULATION OF CARDIOVASCULAR DISEASE Kenneth Walsh, Boston University

12:30pm 4. TBA

11:00am Chart Room Session 12: Myocardial Protection Chair: Dan Kapusta, Louisiana State University Health Sciences Center , New Orleans Co– chair: Kurt Varner, Louisiana State University Health Sci-ences Center, New Orleans

11:00am 1. AMPK MEDIATED CARDIOPROTECTION Lawrence Young, Yale School of Medicine

11:30am 2. REMOTE ISCHEMIC POSTCONDITIONING Karin Przyklenk, Wayne State University, Detroit

12:00pm 3. CAVEOLIN REGULATION OF METABOLISM: IMPLICA-TIONS FOR CARDIAC STRESS ADAPTATION IN MULTIPLE PATHOLOGIES Hemal Patel, University of California, San Diego

12:30pm 4. MICRORNAS, MITOCHONDRIA, AND MYOCARDIAL SALVAGE Charles Steenbergen, John Hopkins University

10

THURSDAY

1st

june


12:30pm

-2:00pm

Quarterdeck Room Break and Poster Session II


Room

Session 13: Heart Failure with Preserved Ejection Fraction Chair: Thomas Thum, Hannover Medical School, Germany Co-chair: Jeff Madwed, Merck, New Jersey

2:00pm 1. TBA

2:30pm 2. PDE SIGNALING IN HFPEF David A. Kass, The Johns Hopkins University Medical Institutions, Baltimore

3:00pm 3. NITRIC OXIDE BASED THERAPEUTICS FOR HFPEF Barry A. Borlaug, Mayo Clinic, Rochester, Minnesota

3:30pm 4. VASCULAR RAREFACTION IN HFPEF Frank W. Smart, Louisiana State University Health Sciences Center, New Orleans

2:00pm Chart Room Session 14: Hypertrophy and Cardiomyopathy Chair: Chen Gao, University of California, Los Angeles Co-chair: Yoshihiko Saito, Nara Medical University, Japan

2:00pm 1. MALADAPTIVE SIGNALING IN CARDIAC HYPERTROPHY Jun Sasoshima, Rutgers New Jersey Medical School

2:30pm 2. COMMON CARDIOMYOPATHY SIGNALING PATHWAYS Jeffrey A. Towbin, Le Bonheur Children’s Hospital, Memphis

3:00pm 3. SARCOMERES AND CARDIAC HYPERTROPHY Leslie A. Leinwand, University of Colorado, Boulder

3:30pm 4. HYPERTROPHIC CARDIOMYOPATHY MUTATIONS IN IPSCS J. Carter Ralphe, University of Wisconsin Health


Room

Session 15: Non-Myocytes in Heart Failure Chair: Merry Lindsay, University of Mississippi Medical Center Co-chair: Jason Gardner, Louisiana State University Health Sciences Center, New Orleans

4:00pm 1. MYOFIBROBLASTS IN CARDIAC DISEASE Jennifer Davis, University of Washington

11


4:30pm 2. NOVEL STRATEGIES TO LIMIT FIBROBLAST ACTIVATION Timothy McKinsey, University of Colorado, Denver

5:00pm 3. THERAPEUTIC TARGETING OF ORGAN FIBROSIS Burns Blaxall, Cincinnati Children’s Hospital Medical Center

5:30pm 4. TBA

4:00pm Chart Room Session 16: Cardiac Gene Therapy Chair: Co-chair: Michael Kapiloff, University of Miami Health System

4:00pm 1. SERCA2 GENE THERAPY Roger Hajjar, Icahn School of Medicine at Mount Sinai, New York

4:30pm 2. TBA

5:00pm 3. GENETIC CORRECTION STRATEGIES FOR MYOPATHIES Elizabeth McNally, Northwestern University, Chicago

5:30pm 4. GRK2 GENE THERAPY FOR HEART FAILURE Joseph Rabinowitz, Temple University, Philadelphia

6:00pm Hilton Riverside Front

Entrance

Aboard Buses to Banguet to Champion Square at the Mercedes - Benz Superdome

6:30pm -

8:30pm

Mercedes - Benz

Superdome, Champion

Square

Encore Room

Dinner Reception and Awards Banquet

8:30pm - Club XLIV Social Celebration

11:30pm Back Entrance of

Encore Room

Aboard Buses to Return to Hilton Riverside Hotel

THURSDAY

1st

june

12

FRIDAY

2nd

june


7:30am Registration Desk Regestration


Room

Plenary Lecture - Pfeffer Distinguished Lecture Chair: Richard Vander Heide, Louisiana State University Health Sciences Center, New Orleans Co-chair: Martin Vila - Petroff, University of La Plata, Argentina

8:00am Tesuji Miura, Sapporo Medical University School of Medicine, Japan “Diabetic Cardiomyopathy -- Adaptation and Maladaptation of Pro-Survival Signals and Metabolism


Room

Session 17: Cardiac Metabolism Chair: Jianyi Zhang, University of Alabama, Birmingham Co-chair: E. Douglas Lewandowski, Sanford Burnham Prebys Medical Discovery Institute, Orlando

9:00am 1. LIPOTOXICITY AND MITOCHONDRIAL DYNAMICS E. Dale Abel, University of Iowa, Carver College of Medicine

9:30am 2. CARDIAC LIPOTOXICITY Ira Goldberg, New York University, Langone Medical Center

10:00am 3. TBA

10:30am 4. TBA Rui-Ping Xiao, Peking University, Institute of Molecular Medicine, China

9:00am Chart Room Session 18: Non-coding and Extracellular RNAs Chair: TBA Co-chair: Gangjian Qin, Northwestern University, Chicago

9:00am 1. REGULATION OF RNAS BY IL-10 Raj Kishore, Temple University, Philadelphia

9:30am 2. IMPACT OF THE TRANSCRIPTION FACTOR GATA2 IN ENDOTHELIAL CELLS ON CARDIAC FAILURE THROUGH REGULATION OF TWO SECRETED LONG NON-CODING RNAS Joerg Heineke, Hannover Medical School, Germany

10:00am 3. LONG NONCODING RNAS REGULATE ENERGY METAB-OLISM IN MICE AND HUMANS Haiming Cao, NHLBI, National Institutes of Health

10:30am 4. THERAPEUTIC POTENTIAL OF NON-CODING RNAS IN HEART FAILURE Rusty Montgmery, miRagen Therapeutics, Boulder

13

FRIDAY

2nd

june


10:30am- 11:00am

Quarterdeck Room Coffee Break.


Room

Session 19: Cardiac Signaling Pathways Chair: Randi Parks, NIH National Heart, Lung, and Blood Insti-tute, Maryland Co-chair: TBA

11:00am 1. TBA

11:30am 2. NOVEL CARDIOPROTECTIVE SIGNALS Kika Sucharov, University of Colorado, Denver

12:00pm 3. EXOSOME MEDIATED CARDIOPROTECTION Geoffrey De Couto, Cedars-Sinai, Los Angeles

12:30pm 4. MITOCHONDRIAL SIGNALING AND CELL SURVIVAL Brian O’Rourke, John Hopkins School of Medicine, Baltimore

11:00am Chart Room Session 20: Aging and Heart Failure Chair: Mohsin Khan, Temple University, Philadelphia Co-chair: Emma Monte, Stanford School of Medicine

11:00am 1. DYSTROPHIN AND AGE-RELATED CARDIAC FAILURE Joseph Metzger, University of Minnesota

11:30am 2. AGING OF THE HEART Marcello Rota, New York Medical College

12:00pm 3. CARDIAC PROGENITOR CELL THERAPY AND AGING Annarosa Leri, Harvard Medical School

12:30pm 4. CARDIAC MYOCARDIAL DYSFUNCTION IN THE AGED HEART Edward Lesnefsky, Virginia Commonwealth University Medical Center


Room

Outstanding Investigator Award Chair: Litsa Kranias, University of Cincinnati College of Medi-cine Co-chair: TBA

12:30pm Xander Wehrens, Baylor College of Medicine, Houston “Calcium Release Unit Defects - Source of Many Cardiac Evils?”

1:30pm Meeting Adjournment.

14

On Tuesday, May 30th at noon, we’re hosting the ECI Luncheon at Drago’s Seafood Restaurant, conveniently located in-

side the first floor of the Hilton Riverside Hotel. Famously known for their charbroiled oysters, Drago’s is the perfect setting

for a “speed dating” lunch with Senior Investigators. Live, learn, and bon appetit!

On Thursday, June 1st at 6:30pm, a Dinner Reception and

Award Banquet will be held at the Mercedes - Benz Super-

dome’s Champion Square. Following this event will be a Social

Celebration in the adjacent room, Club XLIV. Buses will be avail-

able for transportation at the front entrance of the Hilton Riverside

Hotel and will be departing promptly at 6pm. Bus transportation

will also be available at the end of the event and will depart at

11:30pm. Let the good times roll

and celebrate safely.

On Wednesday, May 31st at 7:30pm, we’re

hosting the ECI Social at the Napoleon House

located in the French Quarter on 500 Chartres

Street. Feel free to take a streetcar to this

event. There is a Riverfront Streetcar Depot

located near the front entrance of the Hilton

Riverside Hotel. For only a $1.25 you can

experience New Orleans’ famous streetcar and

enjoy the Mississippi River views. Please

depart at the Toulouse Street stop to arrive to

Napoleon House, which is a block and a half from this stop. Don’t forget to

try Napoleon House’s famous Pimm’s Cup beverage and enjoy socializing

with Pokemon Go!

Social Events & Dinner Reception

Information

Compass

Escalator

Ch

art

River/ Port/

Starboard

Mississippi River

Windward

Leeward

Reg

istr

atio

n

Bridge

Pelican

Qu

arter Deck

Crescent City

Marketplace

Steering

Kabacoff

Riverside Complex

Conference Area

First Level

Escalator

Esc

alat

or

Gift Shop

Guest Room

Elevators Concierge

Front Entrance

Riverfront Streetcar Depot

Grand Salon

Grand Ballroom

World Trade Center

Parking Garage

Po

yd

ras

Str

eet

1st Floor Check-In Counters

Hilton Riverside Hotel

Floorplan

conference of the north american section of ishr€¦ · hemal patel, university of california, san...

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