conference and exhibition · 2007. 3. 16. · penetration enhancer: effects of vehicles and ......
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UB/TIB Hannover 16.Pharmaceutical
TechnologyConference and Exhibition
Divani Caravel HotelAthens, Greece
Volume 2
WednesdayApril 16th 1997
April 15th, 16th and 17th 1997, Athens, Greece
PharmaizeuflbalfTechnBlogg
Conference and. ExhibitionRthens,' 'Greece:,
Plenary Lecture: OLYMPIA HALL
8.30-9.30 COMPARISON BETWEEN FLUID BEDGRANULATORS AND HIGH SHEARGRANULATORSDr Ole Worts, Glatt Norden ApS, Allerod,Denmark.
9.30-9.50 COFFEE
Research Papers
CONTROLLED DRUG DELIVERY:OLYMPIA HALL
9.50-10.20 AN INVESTIGATION OF POLY- 12CAPROLACTONE COPOLYMER BLENDSS. Berrill, K. Viras, J.P.A. Fairclough, C. Booth, S.Brown, D. Attwood and J.H. Collett, Universities ofManchester, U.K. and Athens, Greece, UMIST,Manchester and Sanofi Winthrop, U.K.
10.20-10.50 EVALUATION OF PEMULEN TR-1, A 22POLYACRYLIC ACID COPOLYMER ASMUCOADHESIVE AGAINST LICHEN PLANUSMUCOSAE ORIS USING A COMPOSITE DESIGNAS AN OPTIMISATION TECHNIQUEM. Brisaert & J.A. Plaizier-Vercammen, FreeUniversity of Brussels, Belgium.
10.50-11.20 HOT-MELT COATING TECHNOLOGY: 31INFLUENCE OF COMPRITOL 888 ATO ANDGRANULE SIZE ON THEOPHYLLINE RELEASEA. Faham, P. Prindere, E. Cauture, G. Kalantzis, N.Farah, Ph. Barthelemy & J. Joachim, University ofMarseille, Gattefosse, Saint Priest, France andHoechst Hellas ABEE, Athens, Greece.
11.20 -11.50 NEW TABLET DESIGN FOR THE BIMODAL 38RELEASE OF DRUGSL. Maggi and U. Conte, University of Pavia, Italy.
11.50 -12.20 A DEFINITIVE METHOD TO EVALUATE 46ENTERIC DELIVERY SYSTEMS TARGETINGTHE PROXIMAL SMALL INTESTINEE.P. Sandefer & G.A. Digenis, University ofKentucky, U.S.A.
UB/TIB Hannover 89119 055 848
InternationalAdvisory Board
F. CarliTrieste, Italy.
O.I. CorriganDublin, Ireland
j . CucalaBarcelona, Spain.
M.A. DonsmarkCopenhagen, Denmark
J.L. FordLiverpool, United Kingdom
M.J. GrovesChicago, USA.
A.M. Guyot-HermannLille, France.
T.M. JonesLondon, United Kingdom.
K.A. KhanNottingham, United Kingdom.
|.W. McGinityAustin, USA.
|. RakBratislava, Slovak Republic
D.M. RekkasAthens, Greece ' •
H. RupprechtRegensbuig, Germany.
A. StammStrasbourg, France.
Conference Co-ordinator
M.H. RubinsteinLiverpool, United Kingdom.
Conference Address:
24 Menlove Gardens North,Liverpool LI 8 2E],United Kingdom
Telephone:National 0151 737 1993,lnternational+44 151 737 1993
FaxNational 0151 737 1070,International +44 151 737 1070
April 15th, 16th and 17th 1997, Athens, Greece
•"•';• f f A R G E T E D DRUG DELIVERY:0'.. OLYMPIA HALL
12.20-12.50 PECTIN/CHITOSAN COATINGS FOR COLONIC 70DRUG DELIVERYM.J. Femandez-Hervas & J.T. Fell, University ofSeville, Spain and University of Manchester, U.K.
12.50 -14.00 LUNCH: ATHENS VIEW ROOM
9.30-12.50 TABLE-TOP EXHIBITION:14.00 -17.00 OLYMPIA FOYER
14.00 - 16.00 POSTER-SESSION: OLYMPIA HALL
16.00-16.30 STUDIES ON PHYSICAL PROPERTIES OF 80MIXED PECTIN/ETHYLCELLULOSE FILMSINTENDED FOR COLONIC DRUG DELIVERYG.S. Macleod, J.T. Fell & J.H. Collett, University ofManchester, U.K.
TRANSDERMAL DRUG DELIVERY:OLYMPIA HALL
16.30-17.00 EFFECT OF FATTY ACIDS ON THE 95ALBUTEROL SULPHATE DIFFUSIONTHROUGH CELLULOSE MEMBRANE,HAIRLESS MOUSE SKIN AND HUMANCADAVER SKINN. Ali Chisty, R.A. Bellantone, D.R. Taft & F.M.Plakogiannis, Long Island University, U.S.A.
17.00-17.30 N-DODECYL-2-PYRROLIDONE AS A DERMAL 97PENETRATION ENHANCER: EFFECTS OFVEHICLES AND MODEL DRUGSB.B. Michniak, D.A. Godwin & J.W. Sowell Sr.,University of South Carolina, U.S.A. >
17.30-18.00 THE EFFECT OF DIFFERENT ENHANCERS ON 107THE TRANSDERMAL DELIVERY OFMETAPROTERENOL SULPHATE THROUGHHAIRLESS MOUSE SKIN AND CADAVER SKINA. Komessariou, N. Nicolettos, R. Morgan & F.M.Plakogiannis, Long Island University, U.S.A.
18.00-18.30 IN VITRO EVALUATION OF NIFEDIPINE 108PERMEATION THROUGH HUMAN EPIDERMISUSING EXPERIMENTAL DESIGN TECHNIQUESS.A. Giannakou, P.P. Dallas, DM. Rekkas & N.H.Choulis, University of Athens, Greece.
18.30-19.00 TRANSDERMAL DELIVERY OF TRICYCLIC 124ANTIDEPRESSANTS: AN IN-VITRO STUDYN. Nicolettos, A. KomessariouA F.M. Plakogiannis,
PharmaceuticalTechnology
Conference and ExhibitionRthens,. Greece
InternationalAdvisory Board
F. CarliTrieste, Italy
O.I. CorriganDublin, Ireland.
J. Cucala >
Barcelona, Spain
M.A. DonsmarkCopenhagen, Denmark
J.L FordLiverpool, United Kingdom
M.J. GrovesChicago, USA.
A.M. Guyot-HermannLille, France.
T.M. JonesLondon, United Kingdom
K.A. KhanNottingham, United Kingdom.
J.W. McGinityAustin, USA.
j . RakBratislava, Slovak Republic
D.M. RekkasAthens, Greece
H. RupprechtRegensburg, Germany
A. StammStrasbourg, France
Conference Co-ordinator
M.H. RubinsteinLiverpool, United Kingdom
Conference Address
24 Menlove Gardens North,Liverpool LI 8 2E|,United Kingdom
TelephoneNational 0 I5I 737 1993,International +44 151 737 1993
FaxNational 01 51 737 1070,International 444 151 737 107C
9.30-12.5014.00-17.00
TABLE-TOP EXHIBITION:OLYMPIA FOYER
PharmaceoijcafTephrtplggy
. Conference arid Exhibition
Research Papers
GRANULATION: VERGINA ROOM
9.50 -10.20 DROPLET SIZE MEASUREMENT IN A 125FLUIDISED BED GRANULATORL. Juslin, O. Antikainen, P. Merkku & J. Yliruusi,University of Helsinki and Leiras Oy, Turku,Finland.
10.20-10.50 EVALUATION OF NIR-ABSORPTION FOR 141MOISTURE CONTENT MONITORING OFGRANULES IN A FLUIDISED BEDGRANULATORS. Lehtola, J-P. Mannermaa, P. Ramet & J.Yliruusi, University of Helsinki, Finland.
10.50-11.20 PREPARATION AND EVALUATION OF RAPID- 153RELEASE GRANULES USING A NOVEL HOT-MELT EXTRUSION TECHNIQUEJ.W. McGinity & J.J. Koleng, The University ofTexas at Austin, U.S.A.
11.20-11.50 EVALUATION OF THE MIXTURES OF DIBASIC 155CALCIUM PHOSPHATE ANDMICROCRYSTALLINE CELLULOSE FORPREPARING INITIAL BEADS IN ACENTRIFUGAL GRANULATING PROCESSMd. Harum Ar. Rasid, J. Heinamaki, J. Menna & J.Yliruusi, University of Helsinki, Finland.
11.50-12 20 THE EFFECT OF COLLOIDAL GRADE OF 169MICROCRYSTALLINE CELLULOSE ON THEEXTRUSION RHEOLOGY ANDSPHERONISATION OF CYSTEAMINEHYDROCHLORIDE FORMULATIONSB. Owen, G. Rowley, I.M. Strarkey & M.G.Coulthard, University of Sunderland and RoyalVictoria Infirmary, Newcastle upon Tyne, U.K.
12.20-12.50 RELEASE OF PARACETAMOL FROM 176MICROCRYSTALLINE CELLULOSE UNCOATEDPELLETS PREPARED BY EXTRUSION-SPHERONISATIONB. Bataille, M. Jacob, G. Baylac & P. Yapo,Universities of Montpellier and National CoteD'lvoire, France.
12.50 - 14.00 LUNCH: ATHENS VIEW ROOM
Rthens, Greece
InternationalAdvisory Board
F. CarliTrieste, Italy
O.I. CorriganDublin, Ireland
j . CucalaBarcelona, Spain
M.A. DonsmarkCopenhagen, Denmark
).L. FordLiverpool, United Kingdom.
M.J. GrovesChicago, USA.
A.M. Guyot-HermannLille, France.
T.M. JonesLondon, United Kingdom
K.A. KhanNottingham, United Kingdom.
|.W. McGinityAustin, USA.
j . RakBratislava, Slovak Republic
D.M. RekkasAthens, Greece.
H. RupprechtRegensburg, Germany.
A. StammStrasbourg, France.
Conference Co-ordinator
M.H. RubinsteinLiverpool, United Kingdom.
Conference Address:
24 Menlove Gardens North,Liverpool LI 8 2E|,United Kingdom
lelephone.National 0151 737 1993,International +44 151 737 1993
FaxNational 0151 737 1070,International +44 151 737 1070
Pharmaceytiital
18.30-19.00 THE EFFECT OF SILICON DIOXIDECONCENTRATION ON DRUG RELEASE FROMTRIGLYCERIDE GEL FORMULATIONS, LIQUIDFILLED IN HARD GELATIN CAPSULEST. Benedict, G. Rowley & P.A. Walters, Universityof Sunderland, U.K.
Conference and ExhibitionRthens'Greece•
14.00 - 16.00 POSTER-SESSION: OLYMPIA HALL
GRANULATION: VERGINA ROOM
16.00-16.30 SCALE-UP ON TWO PRODUCTION SCALE 187FIXED BOWL MIXER-GRANULATORSA. Faure, M. Landin, I.M. Grimsey, P. York, M.J.Cliff, R.C. Rowe & A.J. Wigmore, University ofBradford, Zeneca Pharmaceuticals, Macclesfieldand Aeromatic-Fielder Ltd., Eastleigh, U.K.
EXCIPIENTS: VERGINA ROOM
16.30-17.00 STARCH ACETATES: MULTIFUNCTIONAL 192EXCIPIENTS FOR TABLETINGP. Raatikainen, P. Paronen, S. Peltonen, J. Nakari& A. Urtti, University of Kuopio and Primalco Ltd.,Rajamaki, Finland.
17.00-17.30 WATER UPTAKE OF HYDROCOLLOIDS 194G. Bhaskar, J.L. Ford & D.A. Hollingsbee,Convatec (WHRI) and Liverpool John MooresUniversity, U.K.
CAPSULES: VERGINA ROOM
17.30-18.00 RHEOLOGICAL CHARACTERISATION OF 217POLOXAMERS AND POLOXAMER/SILICONDIOXIDE GELS IN RELATION TO LIQUIDFILLING OF HARD GELATIN CAPSULEST. Saeed, G. Rowley & P.A. Walters, University ofSunderland, U.K.
18.00-18.30 EMULSIFYING EFFICIENCY OF SEMI-SOLID 225LIPID EMULSIFYING MATRICES AND ITSIMPLICATION IN DRUG RELEASEL. Halbaut, C. Barbe & M. Aroztegui, University ofBarcelona, Spain.
237
InternationalAdvisory Board
F. CarliTrieste, Italy
O.I. CorriganDublin, Ireland
J. CucalaBarcelona, Spain.
M.A. DonsmarkCopenhagen, Denmark
J.L FordLiverpool, United Kingdom.
M.J. GrovesChicago, USA.
A.M. Guyot-HermannLille, France.
T.M. JonesLondon, United Kingdom
K.A. KhanNottingham, United Kingdom
J.W. McGinityAustin, USA
J. Rak
Bratislava, Slovak Republic
D.M. RekkasAthens, Greece.
H. RupprechtRegensburg, Germany.
A. StammStrasbourg, France
Conference Co-ordinator
M.H. RubinsteinLiverpool, United Kingdom
Conference Address:
24 Menlove Gardens North,Liverpool LI 8 2E|,United Kingdom
TelephoneNational 0151 737 1993,International+44 151 737 1993.
FaxNational 0151 737 1070,International +44 151 737 1070
PharmaceuticalTechnology
Conference and Exhibition •
POSTERS
ON DISPLAY 14.00 - 16.00Olympia Foyer
BIOADHESION
49. CONTINUOUS SHEAR AND TEXTURAL 242ANALYSIS OF BIOADHESIVEPHARMACEUTICAL SEMISOLIDS CONTAININGTETRACYCLINE FOR THE TREATMENT OFPERIODONTITISA.F. Brown, D.S. Jones & A.D. Woolfson, TheQueen's University of Belfast, U.K.
DRUG RELEASE
50. IN-VITRO DISSOLUTION OF CONVENTIONAL 245DILTIAZEM TABLETS IN VARIOUS BUFFERSOLUTIONSI. Ahopelto, J. Yliruusi & E. Kristoffersson,University of Helsinki, Finland.
51. SLOWING DOWN THE RELEASE OF 259DIMEPHOSPHONE INCREASES THEEFFICIENCY OF A DERMATO-COSMETICCREAMS.N. Egorova, L.E. Ziganshina & E.A. Kadirova,Kazan Medical University, Russia.
52. FACTORS INFLUENCING THE DISSOLUTION 264RATE OF NIFEDIPINE/POLYVINYL-PYRROLIDONE CO-PRECIPITATESG. Kalantzis, E. Cauture, P. Prinderre, G. Joachim,Ph. Piccerelle, J.P. Reynier & J. Joachim,University of Marseille, France and Hoechst HellasABEE, Athens, Greece.
53. EFFECT OF DIFFERENT FILLERS ON THE 273DRUG RELEASE OF NITRENDIPINE FROMTABLETSI. Homsek & R. Popovic, ICN Galenika, Belgrade,Yugoslavia
Rthens, ̂ Greece"
InternationalAdvisory Board
F. CarliTneste, Italy
O.I. CorriganDublin, Ireland
J. CucalaBarcelona, Spain
M.A. DonsmarkCopenhagen, Denmark.
J.L. FordLiverpool, United Kingdom
M.J. GrovesChicago, USA
A.M. Guyot-HermannLille, France.
T.M. JonesLondon, United Kingdom.
K.A. KhanNottingham, United Kingdom
J.W. McGinityAustin, USA
J. Rak
Bratislava, Slovak Republic
D.M. RekkasAthens, Greece.
H. RupprechtRegensburg, Germany.
A. StammStrasbourg, France
Conference Co-ordinator
M.H. RubinsteinLiverpool, United Kingdom
Conference Address:
24 Menlove Gardens North,Liverpool LI 8 2EJ,United Kingdom
Telephone.National 0151 737 1993,International +44 151 737 1993
FaxNational 0151 737 1070,International + 44 151 737 1070
Conference andExhibition[•'•'-'•• ''''•<•"•'.'\ •••••" Rthens.'thfeece--
54. THE INFLUENCE OF pH AND AGITATION 277INTENSITY ON DRUG RELEASE FROMTABLETS EVALUATED BY MEANS OFFACTORIAL DESIGNJ. Radovanovic, Z. Duric, M. Jovanovic, L. Nikolic& S. Ibric, Institute For Pharmaceutical Technology,Belgrade, Yugoslavia
55. EVALUATION OF THE PHYSICAL PROPERTIES 286OF A TOLBUTAMIDE/HYDROXYPROPYL-BETA-CYCLODEXTRIN INCLUSION COMPLEXE. Suihko, O. Korhonen, T. Jarvinen, J. Ketolainen,E. Paine & P. Paronen, Universities of Kuopio andTurku, Finland.
56. PHYSICOPHARMACEUTICAL CHARACTER- 295ISATION OF TOLBUTAMIDE/ BETA-CYCLODEXTRIN INCLUSION COMPLEXESF. Veiga & A. Sousa, University of Coimbra,Portugal.
DRUG STRUCTURE
57. DESIGN OF THYROTROPIN ANALOGS USING 297SITE-DIRECTED MUTAGENESIS AND GENETRANSFERF.A. Fares, Carmel Medical Centre and TheRappaport Family Institute for Research in MedicalSciences, Haifa, Israel.
BIOAVAILABILITY
58. A NEW ALGORITHM TO PREDICT DRUG 308BLOOD LEVELS FROM IN VITRO DISSOLUTIONDATA: INTEREST IN PREFORMULATIONP. Odou, C. Barthelemy & H. Robert University ofLille II, France.
STABILITY
InternationalAdvisory Board
F. CarliTrieste, Italy
O.I. CorriganDublin, Ireland.
J. CucalaBarcelona, Spain.
M.A. DonsmarkCopenhagen, Denmark
J.L. FordLiverpool, United Kingdom.
M.J. GrovesChicago, USA
A.M. Guyot-HermannLille, France
T.M. |onesLondon, United Kingdom.
K.A. KhanNottingham, United Kingdom.
J.W. McGinityAustin, USA.
J. RakBratislava, Slovak Republic.
D.M. RekkasAthens, Greece.
H. RupprechtRegensburg, Germany
A. StammStrasbourg, France.
Conference Co-ordinator
M.H. RubinsteinLiverpool, United Kingdom
59. STUDIES OF DIFFERENT INCLUSION 316PROCESSES OF CARBAMAZEPINE WITHHYDROXYPROPYL BETA-CYCLODEXTRIN ANDTHE CHARACTERISATION OF THECOMPLEXESLj. Tasic, J. Milic-Askrabic & D. Rajic, BelgradeUniversity and Military Technical Institute,Belgrade, Yugoslavia.
Conference Address:
24 Menlove Gardens North, •Liverpool LI 8 2EJ,United Kingdom j
telephone. ,'National 0151 737 1993, \International +44 151 737 1993
FaxNational 0151 737 1070, \International +44 151 737 1070
PharmaceuticalTechnology
Conference and ExhibitionRthens: Gret
60. SOLUBILISATION OF TRETINOIN WITH 320SURFACTANTS AND CYCLODEXTRINS ANDTHEIR INFLUENCE ON PHOTO-DEGRADATIONOF TRETINOINM.Brisaert & J. Plaizier-Vercammen, FreeUniversity of Brussels, Belgium
61. THERMAL ANALYSIS IN THE PREDICTION OF 328COMPATIBILITY: RIGHT, WRONG OR NEWAPPROACHES?M. E. Gil Alegre & J.L. Ford, University ofComplutense, Madrid, Spain and Liverpool JohnMoores University, U.K.
62. EFFECT OF SOLVENT ADDITION ON THE 338CHARACTERISTICS OF FREEZE-DRIEDSYNTHETIC PENEM PREPARED USING ANAUTOMATIC PROCESSC. Vecchio, S. De^Luigi Bruschi, M. Varallo & A.gazzaniga, Pharmaceutical Technologies, Veruno,University of Milan and Edwards Alto Vuoto,Trezzano, Italy.
63. CHARACTERISATION OF DRUG/ADDITIVE 346INTERACTIONS USING MODERN ANALYTICALMETHODSL. Colliere, H. Giraud, V. Lavastre & H. Mifsud,Sanofi Recherche, Toulouse, France.
TRANSDERMAL DRUG DELIVERY
64. THE EFFECT OF SKIN PENETRATION 347ENHANCERS ON THE PERMEATION OFDIDEOXYCYTIDINE THROUGH HAIRLESSMOUSE SKIN IN-VITROT.K. Fincher, S.D. Yoo & B.B. Michniak, Universityof South Carolina, U.S.A.
65. IN-VITRO PENETRATION OF ANIONIC, 353CATIONIC AND ZWITTERIONIC LIPOSOMALLYENCAPSULATED ANTISENSEOLIGONUCLEOTIDE INTO HAIRLESS MOUSESKINT.W. Ocheltree, R.C. Mehta, B.B. Michniak & J.C.Shah, ISIS Pharmaceuticals, Carlsbad, Universityof South Carolina and Medical University of SouthCarolina, U.S.A.
InternationalAdvisory Board
F. CarliTrieste, Italy
O.I. CorriganDublin, Ireland.
j . CucalaBarcelona, Spain.
M.A. DonsmarkCopenhagen, Denmark.
J.L. FordLiverpool, United Kingdom
M.J. GrovesChicago, USA
A.M. Guyot-HermannLille, France.
T.M. JonesLondon, United Kingdom
K.A. KhanNottingham, United Kingdom.
|.W. McGinityAustin, USA
J. RakBratislava, Slovak Republic
D.M. RekkasAthens, Greece.
H. RupprechtRegensburg, Germany
A. StammStrasbourg, France.
Conference Co-ordinator
M.H. RubinsteinLiverpool, United Kingdom
Conference Address:
24 Menlove Gardens North,Liverpool LI 8 2E),United Kingdom
TelephoneNational 0151 737 1993,International +44 151 737 1993
FaxNational 0151 737 1070,International +44 151 737 1070
TechnologyConference and Exhibition'
• :: Rthens'r Greece I
66.
67.
68.
69.
70.
71.
TRANSDERMAL (DIADERMATIC) DELIVERY OF 366DICLOFENAC SODIUMD. Parashos, F.M. Plakogiannis, M. Mesiha & A.Babar, Long Island University, U.S.A.
EMULSION AND VESICLE FORMATION OF 367ALPHA-TOCOPHEROL AND ALLOPURINOLWITH EGG YOLK PHOSPHATIDYLCHOLINES. Braha, I. Paduraru, M. Pavelescu, E. Brailoiu &E. Braha, lasi University, Rumania.
EMULSIONS
OF 372
382
391
FORMULATION AND RHEOLOGYSUCROESTER EMULSIONSM.F. Bobin, G. Perraud, N. Claudel, J. Pelletier &M.C. Martini, University Claude Bernard, Lyon,France.
FORMULATION AND EVALUATION OF A O/WEMULSION USING EXPERIMENTAL DESIGNP. Prinderre, Ph. Piccerelle, E. Cauture, G.Kalantzis, J.P. Reynier & J. Joachim, University ofMarseille, France and Hoechst Hellas ABEE,Athens, Greece.
OCULAR DELIVERY
INFLUENCE OF PENETRATION ENHANCERSON THE WEIGHT OF DROPS DELIVEREDFROM FLEXIBLE DROPPER BOTTLESL. Van Santvliet & A. Ludwig, University ofAntwerp, Belgium.
NON-IONIC SURFACTANT BASED TIMOLOL 402MALEATE DISCOMES FOR CONTROLLEDOCULAR DELIVERYS.P. Vyas & N. Mysore, Doctor Harisingh GourVishwavidyalaya, Sagar, India.
72. IN-VITRO AND IN-VIVO EVALUATION OF SOME 405ANTIFUNGAL DRUGS FOR OPHTHALMICAPPLICATIONSS.A. Ibrahim, S.S. Tous, A.K. Al-Hussaini, A.A. El-Shanawany, E.A. Daef, A.S. Aly & M. Mahmoud,Assiut University and Al-Azhar University, Egypt.
InternationalAdvisory Board
F. CarliTrieste, Italy
O.I. CorriganDublin, Ireland.
J. CticalaBarcelona, Spain
M.A. DonsmarkCopenhagen, Denmark
J.L. FordLiverpool, United Kingdom
M.J. GrovesChicago, USA.
A.M. Guyot-HermannLille, France.
T.M. (onesLondon, United Kingdom
K.A. KhanNottingham, United Kingdom
J.W. McGinityAustin, USA
J. RakBratislava, Slovak Republic
D.M. RekkasAthens, Greece
H. RupprechtRegensburg, Germany.
A. StammStrasbourg, France.
Conference Co-ordinator
M.H. RubinsteinLiverpool, United Kingdom
Conference Address:
24 Menlove Gardens North,Liverpool LI 8 2E),United Kingdom
TelephoneNational 0151 737 1993,International +44 151 737 1993
FaxNational 01 51 737 1070,International +44 151 7 i7 1070
PharmaceuticalTechnolqgy
Conference and ExhibitionRthens, Greece
ANALYSIS
73. SPECTROPHOTOMETRIC DETERMINATION OF 424MOCLOBEMIDE BY CHARGE-TRANSFERCOMPLEXATIONM.U. Adikwu & K.C. Ofokansi, University of Nigeria,Nstikka, Nigeria.
74. MOBILE PHASE OPTIMISATION AND ASSAY 433OF CALCIPOTRIOL USING HIGHPERFORMANCE LIQUID CHROMATOGRAPHYJ.J.N. Cirunay, Y.V. Heyden & J. Plaizier-Vercammen, Free University Brussels, Belgium.
75. CHARGE TRANSFER COMPLEXATION FOR 443SPECTROPHOTOMETRIC ASSAY OF CERTAINIMIDAZOLE ANTIFUNGAL DRUGSS.R. El-Shabouri, K.E. Emara & A.M. Mohamed,Assiut University, Egypt.
76. DETECTION POSSIBILITIES AND SEPERATION 455OF SODIUM ARTESUNATE AND ARTELINICACID WITH CAPILLARY ZONEELECTROPHORESISM. Gabriels, M. Jimidar & J.A. Plaizier-Vercammen,Free University Brussels, Belgium.
77. DEVELOPMENT AND COMPARISON OF UV- 465SPECTROPHOTOMETRIC AND THIN LAYERCHROMATOGRAPHIC TECHNIQUES APPLIEDTO ARTELINIC ACID AND SODIUMARTESUNATEM. Gabriels & J.A. Plaizier-Vercammen, FreeUniversity Brussels, Belgium.
78. SIMULTANEOUS DETERMINATION OFACETAMINOPHEN AND CODEINE INPHARMACEUTICAL PREPARATIONS BYDERIVATIVE SPECTROPHOTOMETRYJ. Hanaee, Medical Sciences University of Tabriz,Iran.
474
InternationalAdvisory Board
F. CarliTrieste, Italy
O.I. CorriganDublin, Ireland
J. CucalaBarcelona, Spain.
M.A. DonsmarkCopenhagen, Denmark
J.L. FordLiverpool, United Kingdom
M.J. GrovesChicago, USA.
A.M. Guyot-HermannLille, France
T.M. JonesLondon, United Kingdom.
K.A. KhanNottingham, United Kingdom
J.W. McGinityAustin, USA.
J. RakBratislava, Slovak Republic.
D.M. RekkasAthens, Greece.
H. RupprechtRegensburg, Germany
A. StammStrasbourg, France.
Conference Co-ordinator
M.H. RubinsteinLiverpool, United Kingdom
DRYING
79. DRYING OF LACTOSE AND MANNITOLGRANULES MADE IN A LABORATORY SCALEHIGH SHEAR MIXERT. Niskanen, M. Niskanen & J. Yliruusi, OrionCorporation, Espoo and University of Helsinki,Finland.
476 Conference Address:
24 Menlove Gardens North,Liverpool LI 8 2E|,United Kingdom
Telephone.National 0151 737 1993,International +44 151 737 1993
Fax.National 0151 737 1070,International +44 151 737 1070
80.
81.
82.
83.
84.
85. COMPARISON OF DIFFERENT METHODS FORMEASURING THE PARTICLE SIZE OFMETERED DOSE INHALERSM. Nagy, Z. Bokros, E. Barczai, Z. Szabados & M.Gora, EGIS Pharmaceuticals Ltd., Hungary.
SUPPOSITORIES
Conference and Exhibition' ' .'..:.. .r. "Rthehs,- G'reece-
508
UNUSUAL DRYING BEHAVIOUR OF GLUCOSEGRANULESM. Niskanen, T. Niskanen, I. Mattila & J. Yliruusi,Orion Corporation, Espoo and University ofHelsinki, Finland.
EXCIPIENTS
A COMPARISON OF THE COMPRESSIONPERFORMANCE OF AN ALTERNATIVESOURCE OF MICROCRYSTALLINECELLULOSE TO AVICELM.J. Elmer, Abbott Laboratories, U.K.
COMPUTATIONAL ELASTICITY OF 509ANHYDROUS BETA-LACTOSEJ. Paivarinta, A. Poso, J. Gynther, E. Suihko & J.Ketolainen, University of Kuopio, Finland.
PHYSICAL CHARACTERISATION OF SPRAY- 517DRIED LACTOSEY. von Scholz, S.A. Merkle & F.U. Flother, TheR.W. Johnson Pharmaceutical Research Institute,Schaffhausen, Switzerland.
INHALATION TECHNOLOGY
TRIBOELECTRIFICATION AND ADHESION 523DURING THE MIXING OF DRY POWDERINHALER FORMULATIONSF. Bennett, G. Rowley, P. Carter & Y. Dandiker,University of Sunderland, U.K.
528
InternationalAdvisory Board
F. CarliTries te , Italy
O.I. CorriganDublin, Ireland
J. CucalaBarcelona, Spain.
M.A. DonsmarkCopenhagen, Denmark
J.L FordLiverpool, United Kingdom
M.J. GrovesChicago, USA
A.M. Guyot-HermannLille, France.
T.M. JonesLondon, United Kingdom
K.A. KhanNottingham, United Kingdom
|.W. McGinityAustin, USA
J. RakBratislava, Slovak Republic.
D.M. RekkasAthens, Greece.
H. RupprechtRegensburg, Germany.
A. StammStrasbourg, France
Conference Co-ordinator
M.H. RubinsteinLiverpool, United Kingdom
86. GELLING OF A RECTAL SOLUTION 530CONTAINING SHORT-CHAIN FATTY ACIDSV. Astre, C. Tuleu, C. Charrueau & J.C. Chaumeil,University Rene Descartes, Paris, France.
87. RELEASE CHARACTERISTICS OF 538METRONIDAZOLE FROM FATTY AND WATERSOLUBLE BASEST. Kovacevic, M. Zivkovic, S. Popovic & T. Milic,ICN Institute, Belgrade, Yugoslavia.
Conference Address:
24 Menlove Gardens North,Liverpool L18 2E|,United Kingdom
TelephoneNational 0151 737 1993,International +44 151 737 1993
FaxNational 0151 737 1070,International +44 151 737 1070
PharmaceuffcMTectihtiltigff
Conference-and Exhibition.thens," Greece'
88. EFFECT OF MODERN ADDITIVES ON THE IN- 541VITRO DRUG RELEASE OF DIURETIC RECTALSUPPOSITORIESG. Regdon Jr., D. Deak, S. Berko & I. Eros, AlbertSzent-Gyorgyi Medical University, Szeged,Hungary.
MICROBIOLOGY
89. THE INTERACTION OF OPHTHALMIC 547ADHESIVES WITH A QUATERNARYAMMONIUM ANTI-MICROBIAL PRESERVATIVEN. Castellic-Munier, M. Boix & I. Maroteaux,Allergan R & D, Vallauris, France.
90. VAPOUR PHASE HYDROGEN PEROXIDE 548STERILISATION TECHNOLOGY FOR STERILITYTESTINGI. Maroteaux, C. Leccia & L. Foucher, Allergan R &D, Vallauris, France.
91. ANTIBIOTIC RESISTANCE AND THE ROLE OF 549MICROBIAL BIOFILMD.S. Jones, J.G. McGovern, A.D. Woolfson & S.P.Gorman, The Queen's University of Belfast, U.K.
92. NEW MICROBIOCIDAL MECHANISMS WITH 552SKIN PEPTIDES TO TREAT AND PREVENTPARASITIC INFECTIONS: NOVELPHARMACEUTICAL APPROACHI. Vouldoukis, M.C. Venier-Julienne, D. Mazier, M.Gentilini & L. Monjour, School of Medicine Paris VI,CNRS Paris and University of Angers, France
InternationalAdvisory Board
F. CarliTrieste, Italy.
O.I. CorriganDublin, Ireland.
J. CucalaBarcelona, Spain.
M.A. DonsmarkCopenhagen, Denmark.
J.L. FordLiverpool, United Kingdom.
M.J. GrovesChicago, USA.
A.M. Guyot-HermannLille, France.
T.M. JonesLondon, United Kingdom.
K.A. KhanNottingham, United Kingdom.
J.W. McGinityAustin, USA.
|. RakBratislava, Slovak Republic
D.M. RekkasAthens, Greece
H. RupprechtRegensburg, Germany
A. StammStrasbourg, France.
Conference Co-ordinator
M.H. RubinsteinLiverpool, United Kingdom.
Conference Address:
24 Menlove Gardens North,Liverpool LI 8 2E),United Kingdom
Telephone.National 0151 737 1993,International +44 151 737 1993
Fax.National 0151 737 1070,International +44 151 737 1070