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The NIkf Guide announces scient~fic initiatives and provides p~licym d administrative infi)rmation t o indivi duals and organizationswho need t o he kept informed o f opportunities, requirements. and changes in extra­mucil progums administered by the Nationd Inzrirllrr*sofHealth

V o l . 19, No. 13 March 30 , 1990

NIH GUIDE - Vol. 19, No. 13, March 30, 1990

NOTICES

REVISING THE 398 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Division of Research Grants Index: DIVISION OF RESEARCH GRANTS

NOTICES OF AVAILABILITY (RFPs AND RFAs)

EVALUATION IN PRIMATES OF CANDIDATE VACCINES FOR SIMIAN ACQUIREDIMMUNODEFICIENCY SYNDROME (RFP) ............................................. 1 National Institute of Allergy and Infectious Diseases Index: ALLERGY, INFECTIOUS DISEASES

THE EFFECT OF SELF-APPLIED FLUORIDE ON THE INCIDENCE OF ROOT CARIES AND CORONAL CARIES IN AN ADULT POPULATION (RFP) ............................. 2 National Institute of Dental Research Index: DENTAL RESEARCH

PROGRAM PROJECTS ON AUTOIMMUNE MECHANISMS IN DISEASE (RFA AI-90-08) . . . . . . . . . 2 National Institute of Allergy and Infectious Diseases Index: ALLERGY, INFECTIOUS DISEASES

COOPERATIVE AGREEMENT FOR A RESIDENTIAL DRUG ABUSE TREATMENT RESEARCH DEMONSTRATION PROGRAM IN THE DISTRICT OF COLUMBIA (RFA DA-90-12) . . . . . . . . . . . . 4 National I n s t i t u t e on Drug Abuse Index: DRUG ABUSE

CANCER PREVENTION AND CLINICAL RESEARCH IN UNDER-SERVED POPULATIONS (RFA CA-90-14) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 National Cancer Institute Index: CANCER

BEHAVIORAL RESEARCH IN SUPPORT OF AIDS PREVENTION (RFA NR-90-02) . . . . . . . . . . . . 7 National Institutes of Health Index: NATIONAL INSTITUTES OF HEALTH

PERINATAL BEHAVIORAL DEVELOPMENT (RFA 90-HD/MH-08) .......................... 8 National Institute of Child Health and Human DevelopmentNational Institute of Mental Health Index: CHILD HEALTH, HUMAN DEVELOPMENT, MENTAL HEALTH

ONGOING PROGRAM ANNOUNCEMENTS

ADAMHA SMALL INSTRUMENTATION GRANT PROGRAM .................................. 9 Alcohol, Drug Abuse, and Mental Health Administration Index: ALCOHOL, DRUG ABUSE, MENTAL HEALTH

SPECIAL EMPHASIS RESEARCH CAREER AWARD IN LABORATORY ANIMAL SCIENCE . . . . . . . . . 10 National Center for Research Resources Index: RESEARCH RESOURCES

NEUROENDOCRINOLOGY OF HUMAN STRESS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 National Institute of Diabetes, Digestive and Kidney Diseases Index: DIABETES, DIGESTIVE DISEASES, KIDNEY DISEASES

ERRATUM

NOTICE OF SOLICITATION OF PUBLIC COMMENTS FOR THE NATIONAL PANEL FOR RESEARCH IN NEUROLOGICAL DISORDERS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 National Institute of Neurological Disorders and Stroke Index: NEUROLOGICAL DISORDERS, STROKE

d

NOTICES

*8Il,&

1 Id

REVISING THE 398

P.T. 34; K . W . 1014002

D i v i s i o n o f Research Gran t s

An N I H committee, w i t h r e p r e s e n t a t i v e s from o t h e r a g e n c i e s i n t h e P u b l i c H e a l t h S e r v i c e , h a s begun work on r e v i s i n g t h e PHS 398 Research Grant A p p l i c a t i o n K i t . The committee welcomes any s u g g e s t i o n s o r comments from t h e s c i e n t i f i c community o r from o t h e r i n t e r e s t e d p e r s o n s r e g a r d i n g ways t o improve t h e a p p l i c a t i o n k i t . Sugges t ions cou ld concern items such as t h e page l i m i t a t i o n s , appendix material , i n s t r u c t i o n s f o r f i l l i n g i n i tems, s t r u c t u r e o f t h e s c i e n t i f i c p r o p o s a l , a b s t r a c t , use of key words, and t h e a p p l i c a n t ' s p r o f e s s i o n a l a s s o c i a t e s and c o l l a b o r a t o r s . Other areas o f concern cou ld be t h e p e r s o n a l d a t a s e c t i o n , as w e l l as t h e a s s u r a n c e s t h a t are r e q u e s t e d o f t h e a p p l i c a n t o r a p p l i c a n t o r g a n i z a t i o n . Because o f t i m e c o n s t r a i n t s , t h e s e s u g g e s t i o n s or comments must be r e c e i v e d by A p r i l 19, 1990. P l e a s e send them t o :

D r . P a t r i c i a S t r a a t Chief o f t h e Referral S e c t i o n D i v i s i o n o f Research Gran t s N a t i o n a l I n s t i t u t e s o f Hea l th Westwood B u i l d i n g , Room 248 Bethesda, MD 20892

NOTICES OF AVAILABILITY (RFPs AND RFAs)

EVALUATION I N PRIMATES OF CANDIDATE VACCINES FOR SIMIAN ACQUIREDIP1PlUNODE F IC IENCY SYNDROME

RFP AVAILABLE: RFP-NIH-NIAID-DAIDS-91-05

P.T. 34; K.W. 0715008, 0740075, 0201058

N a t i o n a l I n s t i t u t e o f A l l e r g y and I n f e c t i o u s Diseases

The N a t i o n a l I n s t i t u t e o f A l l e r g y and I n f e c t i o u s Diseases ( N I A I D ) h a s a r equ i r emen t t o e s t a b l i s h s imian immunodeficiency v i r u s (SIV) v a c c i n e e v a l u a t i o n u n i t s (SVEUs) t h a t w i l l conduct v a c c i n e c l i n i c a l t r i a l s on c a n d i d a t e SIV v a c c i n e s .

T h i s NIAID-sponsored p r o j e c t w i l l t a k e approx ima te ly f i v e (5 ) y e a r s t o complete . A cost-reimbursement c o n t r a c t i s a n t i c i p a t e d and two (2 ) awards are expec ted t o be made.

T h i s is an announcement for an a n t i c i p a t e d R e q u e s t for Proposal (RFP).RFP-NIK-NIAID-DAIDS-91-05 s h a l l be i s s u e d on o r about A p r i l 1 0 , 1990, w i t h a c l o s i n g d a t e t e n t a t i v e l y s e t f o r May 25, 1990.

Requests f o r t h e RFP s h a l l be d i r e c t e d i n w r i t i n g t o :

John M . O'Brien Con t rac t Management Branch 6 0 0 3 Execu t ive Blvd. Con t ro l Data B u i l d i n g , Room 214P N a t i o n a l I n s t i t u t e of A l l e r g y and I n f e c t i o u s Diseases N a t i o n a l I n s t i t u t e s o f Hea l th Bethesda, MD 20892 Telephone: ( 3 0 1 ) 496-0195

To r c c e i v e a copy o f t h e RFP, p l e a s e supp ly t h i s o f f i c e w i t h two ( 2 )s e l f - a d d r e s s e d l a b e l s . A l l r e s p o n s i b l e s o u r c e s may submit a p r o p o s a l which w i l l be c o n s i d e r e d .

T h i s adve r t i s emen t does n o t commit t h e Government t o award a c o n t r a c t .

N I H G U I D E - Vol. 19, No. 13, March 3 0 , 1990 - Page 1

THE EFFECT OF SELF-APPLIED FLUORIDE ON THE INCIDENCE OF ROOT CARIES AND CORONAL CARIES I N AN ADULT POPULATION

RFP AVAILABLE: NIH-NIDR-2-90-4R

P.T. 34; K . W . 0715148, 0740000, 0411005

N a t i o n a l I n s t i t u t e o f Denta l Research

The N a t i o n a l I n s t i t u t e o f Denta l Research p l a n s t o i s s u e a r e q u e s t f o r p r o p o s a l s (RFP) f o r a f i v e - y e a r c l i n i c a l i n v e s t i g a t i o n t o de t e rmine t h e e f f e c t i v e n e s s o f s e l e c t e d s e l f - a p p l i e d t h e r a p e u t i c a g e n t s i n r educ ing t h e i nc idence o f r o o t and c o r o n a l car ies i n an a d u l t p o p u l a t i o n r e s i d i n g i n a subopt imal o r n o n - f l u o r i d a t e d community. P a r t i c i p a n t s must be s e l e c t e d w i t h care, based upon r e l e v a n t c h a r a c t e r i s t i c s t hough t t o be impor tan t f a c t o r s i n i d e n t i f y i n g a d u l t s a t r i s k f o r co rona l and, e s p e c i a l l y , r o o t c a r i e s . P r o j e c t e d a t t r i t i o n l e v e l s o f p a r t i c i p a n t s a l s o must be cons ide red i n t h e s e l e c t i o n o f a s u i t a b l e s t u d y p o p u l a t i o n . The I n s t i t u t e p l a n s t o make one award from t h i s s o l i c i t a t i o n .

RFP No. NIH-NIDR-2-90-4R w i l l be a v a i l a b l e on approximate ly A p r i l 16, 1990, w i t h a due d a t e f o r p r o p o s a l s o f June 8,. 1990. W r i t t e n r e q u e s t s f o r a copy o f t h e RFP shou ld be s e n t t o :

M s . Marion L . B l e v i n s Cont rac t Management S e c t i o n N a t i o n a l I n s t i t u t e o f Denta l Research N a t i o n a l I n s t i t u t e s o f Hea l th Westwood Bu i ld ing , Room 521 Bethesda, MD 20892

PROGRAM PROJECTS ON AUTOIMMUNE MECHANISMS I N DISEASE

RFA AVAILABLE: AI-90-08

P.T. 34; K.W. 0715015, 0715026, 0755030, 0765033, 0710070, 0710030

N a t i o n a l I n s t i t u t e o f A l l e r g y and I n f e c t i o u s Di seases

Letter o f I n t e n t Rece ip t Date : May 4 , 1990 A p p l i c a t i o n Rece ip t Date: J u l y 10 , 1990

BACKGROUND INFORMATION

The C l i n i c a l Immunology Branch o f t h e D i v i s i o n o f A l l e r g y , Immunology and T r a n s p l a n t a t i o n (DAIT) o f t h e N a t i o n a l I n s t i t u t e o f A l l e r g y and I n f e c t i o u s Diseases ( N I A I D ) s u p p o r t s r e s e a r c h on humoral, c e l l u l a r and molecular mechanisms o f immune system f u n c t i o n s i n h e a l t h and d i s e a s e and t h e a p p l i c a t i o n o f t h i s b a s i c b iomedica l knowledge t o c l i n i c a l l y r e l e v a n t problems. T h i s Request f o r A p p l i c a t i o n s (RFA) is in t ended t o encourage and i n v i t e t h e development o f program p r o j e c t a p p l i c a t i o n s from c o l l a b o r a t i n gb a s i c s c i e n c e r e s e a r c h and c l i n i c a l i n v e s t i g a t i v e groups concerned w i t h i n t e g r a t e d s t u d i e s on autoimmune mechanisms i n d i s e a s e .

RESEARCH GOALS AND SCOPE

Immune system mediated t i s s u e i n j u r y (autoimmunity) is a major area o f endeavor under t h e purview o f t h e N I A I D C l i n i c a l Immunology Branch. Wi th in t h i s s p e c i f i c r e s e a r c h a r e a , t h e g o a l s o f t h e program p r o j e c t s are: 1 )i n c r e a s e d unde r s t and ing o f t h e e t i o l o g y and p a t h o g e n e t i c mechanisms involved i n autoimmune d i s e a s e s ; and 2 ) t h e g e n e r a t i o n o f an expanded knowledge base t h a t can be a p p l i e d t o t h e development o f improved measures o f d i a g n o s i s , t r e a t m e n t , and p r e v e n t i o n o f a wide v a r i e t y o f d i s o r d e r s i n v o l v i n gimmunological ly mediated inf lammatory r e a c t i o n s .

The d e s i g n and scope o f t h e s e program p r o j e c t s are in t ended t o i n c l u d e s t u d i e s on a l l a s p e c t s o f immune r e sponses r e s p o n s i b l e f o r o r a s s o c i a t e d w i t h d i s e a s e s i n v o l v i n g t i s s u e i n j u r y o r damage i n which a r o l e f o r elements o r f u n c t i o n s o f t h e immune system can be i d e n t i f i e d . Broad approaches t o r e s e a r c h on autoimmune mechanisms i n d i s e a s e may i n c l u d e s t u d i e s concerned wi th r e l e v a n t a r e a s o f g e n e t i c s , c e l l and molecular b io logy , b iochemis t ry , phys io logy ,microbio logy , and pharmacology.

O f s p e c i a l i n t e r e s t t o N I A I D are program p r o j e c t s w i t h r e s e a r c h emphasis i n d e f i n e d a r e a s o f i n v e s t i g a t i o n t h a t show promise i n e l u c i d a t i o n o f b a s i c immune mechanisms and t h e i r a p p l i c a t i o n t o c l i n i c a l autoimmune d i s o r d e r s . Recent ev idence i m p l i c a t e s immune-mediated mechanisms i n t h e p a t h o g e n e s i s of

..-

.e

N I H G U I D E - Vol. 19, No. 13 , March 30, 1990 - Page 2

d i s e a s e s of t h e nervous system, s k i n , endoc r ine o rgans and g a s t r o i n t e s t i n a l t r a c t . Thus, i n a d d i t i o n t o s t u d i e s o f w e l l r ecogn ized autoimmune d i s e a s e s , e . g . , s y s t e m i c l u p u s e ry thematosus , rheumatoid a r t h r i t i s , ant ibody-mediatedthrombocytopenia and autoimmune hemoly t i c anemia, N I A I D encouragesi n v e s t i g a t o r s t o d e s i g n and develop s t u d i e s aimed a t c l a r i f y i n g t h e r o l e o f autoimmune mechanisms i n endoc r ine , de rma to log ic , n e u r o l o g i c and g a s t r o i n t e s t i n a l d i s o r d e r s .

The N I H p l a c e s s p e c i a l emphasis on t h e need f o r i n c l u s i o n o f m i n o r i t i e s and women i n s t u d i e s o f d i s e a s e s which d i s p r o p o r t i o n a t e l y a f fec t them and a l s o u r g e s t h a t a p p l i c a n t s g i v e added a t t e n t i o n , where f e a s i b l e and a p p r o p r i a t e , t o t h e i r i n c l u s i o n i n o t h e r c l i n i c a l s t u d i e s . For proposed popu la t ion -baseds t u d i e s which i n c l u d e n e i t h e r women n o r m i n o r i t i e s , a c lear r a t i o n a l e f o r n o t i n c l u d i n g them must be p rov ided . I n a t t e m p t i n g t o i n c l u d e e i t h e r group i n a p a r t i c u l a r s t u d y , a t t e n t i o n must be p a i d t o such i s s u e s as r e s e a r c h d e s i g n and sample s i z e . For f u r t h e r i n fo rma t ion , c o n s u l t t h e s t a t e m e n t s o f N I H p o l i c y on t h e i n c l u s i o n o f m i n o r i t i e s and women i n s t u d y p o p u l a t i o n s t h a t appeared i n t h e N I H Guide f o r Gran t s and C o n t r a c t s . The i s s u e d a t e d September 25, 1987 (Vol . 16, No. 32, pp. 3-41, announced t h e p o l i c y on m i n o r i t i e s ; t h e one on women appeared i n t h e i s s u e d a t e d Janua ry 23, 1987 (Vol . 16, No. 3 ) .

MECHANISM OF SUPPORT

Program p r o j e c t g r a n t s are awarded t o an i n s t i t u t i o n on b e h a l f o f a programd i r e c t o r f o r t h e s u p p o r t o f a b r o a d l y based, m u l t i d i s c i p l i n a r y , long-termr e s e a r c h program t h a t h a s a s p e c i f i c major o b j e c t i v e o r b a s i c theme. A program p r o j e c t g e n e r a l l y i n v o l v e s t h e o rgan ized e f f o r t s o f groups o f i n v e s t i g a t o r s , members o f which conduct r e s e a r c h p r o j e c t s r e l a t e d t o t h e o v e r a l l program o b j e c t i v e . The g r a n t can p r o v i d e s u p p o r t f o r t h e p r o j e c t s and f o r c e r t a i n b a s i c r e s o u r c e s s h a r e d by i n d i v i d u a l s i n t h e program p r o j e c t where t h e s h a r i n g f a c i l i t a t e s t h e t o t a l r e s e a r c h e f f o r t . Each p r o j e c t suppor t edunder a program p r o j e c t g r a n t i s expec ted t o c o n t r i b u t e t o and be d i r e c t l yr e l a t e d t o t h e common theme o f t h e program; t h e p r o j e c t s under t h e d i r e c t i o n o f a p r i n c i p a l i n v e s t i g a t o r shou ld demons t r a t e an e s s e n t i a l e lement o f u n i t yand in t e rdependence . I n FY 1991 t h e N I A I D p l a n s t o award a t l e a s t two programp r o j e c t g r a n t s submi t t ed i n r e sponse t o t h i s RFA and, depending on a v a i l a b i l i t y o f funds and s c i e n t i f i c meri t , more t h a n two. Reques t s f o r s u p p o r t shou ld be l i m i t e d t o no more t h a n $ 5 0 0 , 0 0 0 d i r e c t c o s t s p e r y e a r .

E L I G I B I L I T Y

ONLY DOMESTIC INSTITUTIONS ARE ELIGIBLE TO APPLY.

METHOD OF APPLYING

A p p l i c a t i o n s may be submi t t ed by any domest ic p u b l i c o r p r i v a t e n o n p r o f i t o r pro f i t -mak ing o r g a n i z a t i o n s . Be fo re p r e p a r i n g an a p p l i c a t i o n , t h e p r o s p e c t i v e a p p l i c a n t shou ld r e q u e s t a copy o f t h e N I A I D In fo rma t ion Brochure on ProgramP r o j e c t and Cen te r Gran t s from:

Kamal K . Mi t ta l , D.V.M. , Ph.D. Execu t ive S e c r e t a r y A l l e r g y , Immunology and T r a n s p l a n t a t i o n Research Committee N a t i o n a l I n s t i t u t e o f A l l e r g y and I n f e c t i o u s Diseases N a t i o n a l I n s t i t u t e s of H e a l t h Westwood B u i l d i n g , Room 3A-07 Bethesda, MD 20892 Telephone: ( 3 0 1 ) 496-3528

STAFF CONTACT

A more d e t a i l e d RFA may be o b t a i n e d from:

Howard B . Dicl t ler , M . D . Chie f , C l i n i c a l Immunology Branch D i v i s i o n o f A l l e r g y , Immunology and T r a n s p l a n t a t i o n N a t i o n a l I n s t i t u t e o f A l l e r g y and I n f e c t i o u s Disease Westwood B u i l d i n g , Room 755 Bethesda, MD 20892 Telephone : ( 3 0 1 1 496-71 04 T e l e f a x : (301) 402-0175

P r o s p e c t i v e a p p l i c a n t s are encouraged t o submit a one-page l e t t e r of i n t e n t byMay 4, 1990, t o D r . Mi t ta l t h a t i n c l u d e s a d e s c r i p t i v e t i t l e o f t h e o v e r a l l proposed r e s e a r c h , t h e name o f t h e P r i n c i p a l I n v e s t i g a t o r and a l i s t o f t h e names o f key i n v e s t i g a t o r s and t h e i r i n s t i t u t i o n ( s 1 . The l e t t e r o f i n t e n t i s r e q u e s t e d i n o r d e r t o p r o v i d e an i n d i c a t i o n o f t h e number and scope o f a p p l i c a t i o n s t o be reviewed so as t o a l l o w e a r l y p r e p a r a t i o n s f o r review, as

N I H G U I D E - Vol, 19, No. 13, March 30, 1990 - Page 3

w e l l as t o promote e a r l y i n t e r a c t i o n s between a p p l i c a n t s and N I A I D s t a f f . The l e t t e r o f i n t e n t i s n o t b i n d i n g and does n o t commit t h e s e n d e r t o submit a n a p p l i c a t i o n , n o r i s it a r equ i r emen t f o r submission of a n a p p l i c a t i o n .

THE RFA LABEL AVAILABLE I N THE 10/88 REVISION OF APPLICATION FORM 398 MUST BE AFFIXED TO THE BOTTOM OF THE FACE PAGE. FAILURE TO USE THIS LABEL COULD RESULT I N DELAYED PROCESSING OF YOUR APPLICATION SrJCH THAT I T MAY NOT REACH THE REVIEW COMMITTEE I N TIME FOR REVIEW.

COOPERATIVE AGREEMENT FOR A RESIDENTIAL DRUG ABUSE TREATMENT RESEARCH DE?IONSTRATION PROFIXAM I N THE DISTRICT OF COLUklBIA

RFA AVAILABLE: DA-90-12

P .T . 34; K . W . 0404009, 0403004

N a t i o n a l I n s t i t u t e on Drug Abuse

Le t te r o f I n t e n t Rece ip t Date: May 1 2 , 1990 A p p l i c a t i o n Rece ip t Date: June 12, 1990

PURPOSE

The purpose o f t h i s Request f o r A p p l i c a t i o n s (RFA) i s t o award a c o o p e r a t i v e agreement t o s u p p o r t a d rug abuse t r e a t m e n t r e s e a r c h demons t r a t ion program i n t h e D i s t r i c t o f Columbia. T h i s program w i l l e s t a b l i s h , t e s t and e v a l u a t e t h e e f f e c t i v e n e s s o f a d rug abuse t r e a t m e n t approach based on sho r t - t e rm ( i . e . , 6 months d u r a t i o n ) t r e a t m e n t i n a t h e r a p e u t i c community fo l lowed by i n t e n s i v e a f te rcare i n o r d e r t o examine t h e e f f e c t i v e n e s s o f t h i s approach i n p a r t i c u l a rd i a g n o s t i c and p a t i e n t / p o p u l a t i o n subgroups. The District o f Columbia was s e l e c t e d a s t h e s i t e f o r t h i s model t r e a t m e n t r e s e a r c h demons t r a t ion p r o j e c tbecause o f t h e e x t e n t and i n t e n s i t y o f t h e d rug abuse problem, a v a i l a b i l i t y of c l i e n t s , and because t h e combinat ion o f p a t i e n t subgroups and t y p e s o f d rugabuse problems l e n d s i t s e l f t o a r e s e a r c h demons t r a t ion p r o j e c t t h a t may be a b l e t o b e r e p l i c a t e d i n o t h e r p a r t s o f t h e c o u n t r y . A s p a r t o f t h e N a t i o n a l Drug Con t ro l S t r a t e g y , r e l e a s e d i n September 1989, Washington, D . C . w a s i d e n t i f i e d as t h e f i r s t s i t e f o r a model d rug t r e a t m e n t demons t r a t ion program.

T h i s RFA is a j o i n t i n i t i a t i v e between t h e N a t i o n a l I n s t i t u t e on Drug Abuse ( N I D A ) and t h e Alcohol , Drug Abuse, and Mental Hea l th A d m i n i s t r a t i o n (ADAMHA)O f f i c e f o r Treatment Improvement ( O T I ) . OTI was e s t a b l i s h e d t o p r o v i d en a t i o n a l l e a d e r s h i p f o r t h e F e d e r a l e f f o r t t o enhance approaches and programsf o c u s i n g on t h e t r e a t m e n t o f d rug a b u s e r s as w e l l as a s s o c i a t e d problems o f a l coho l i sm and mental i l l n e s s .

Coopera t ive agreement awards w i l l be made under t h e a u t h o r i t y o f s e c t i o n 301 o f t h e P u b l i c Hea l th S e r v i c e A c t ( 4 2 U.S.C. 2 4 1 ) .

RESEARCH OBJECTIVES

T h i s Coopera t ive Agreement w i l l p r o v i d e s u p p o r t f o r : ( 1 ) a 60-bed r e s i d e n t i a l t r e a t m e n t f a c i l i t y o f f e r i n g a six-month r e s i d e n t i a l t r e a t m e n t program fo l lowed by a six-month a f t e r c a r e program; ( 2 ) a 20-bed cr is is u n i t t o be p a r t o f t h e f a c i l i t y ; and ( 3 ) r e s e a r c h and t r e a t m e n t c o s t s a s s o c i a t e d w i t h t h i s programand comparison s u b j e c t s a s s i g n e d t o o t h e r r e s i d e n t i a l programs i n t h e D . C . a rea . The cr is is u n i t w i l l p r o v i d e sho r t - t e rm i n t e r v e n t i o n f o r p s y c h o l o g i c a l o r f a m i l y crises and b r i e f medical d e t o x i f i c a t i o n i n s e l e c t e d c a s e s b u t i s no t i n t e n d e d t o hand le medical emergencies . The r e s e a r c h demons t r a t ion p r o j e c tw i l l o b t a i n p a t i e n t s t h rough a D i a g n o s t i c , Refer ra l , and Data Management U n i t , t o be e s t a b l i s h e d under a s e p a r a t e Coopera t ive Agreement (DA-90-11).

T h i s demons t r a t ion p r o j e c t w i l l e v a l u a t e t h e comparat ive e f f e c t i v e n e s s o f t h i s t y p e o f r e s i d e n t i a l t r e a t m e n t f o r t h e t y p e s o f d rug abuse c l i e n t s and problemst h a t are found i n t h e D i s t r i c t o f Columbia i n c l u d i n g p s y c h i a t r i c co-morbidi ty .The p r o j e c t w i l l a l s o s e e k t o examine which s e r v i c e s are e s s e n t i a l componentsf o r a c h i e v i n g t h e r a p e u t i c outcomes f o r d i f f e r e n t t y p e s o f c l i e n t s / p r o b l e m s , as w e l l as a number of s u b - s t u d i e s t o e v a l u a t e such f a c t o r s a s d i a g n o s t i c and t r e a t m e n t i s s u e s i n v o l v i n g p a r t i c u l a r c o - m o r b i d i t i e s , and t h e p r e d i c t i v e v a l u e o f p a r t i c u l a r d i a g n o s t i c s u b c l a s s i f i c a t i o n s o r i n s t r u m e n t s w i t h p a r t i c u l a r t y p e s o f c l i e n t s and forms o f s e r v i c e s .

N I D A w i l l p r o v i d e space f o r t h i s f a c i l i t y i n a government-owned o r l e a s e d b u i l d i n g i n Washington, D . C .

I n FY 1990, it i s e s t i m a t e d t h a t $ 2 . 0 m i l l i o n t o $ 2 . 5 m i l l i o n w i l l b e a v a i l a b l e t o s u p p o r t one award under t h i s RFA ( i n c l u d i n g d i r e c t and i n d i r e c t

“P.

N I H G U I D E - Vol. 1 9 , No. 13, March 3 0 , 1990 - Page 4

c o s t s ) . A p p l i c a n t s may r e q u e s t up t o 3 y e a r s of s u p p o r t . Annual awards w i l l be made s u b j e c t t o con t inued a v a i l a b i l i t y o f funds and p r o g r e s s ach ieved .

MECHANISM OF SUPPORT: Coopera t ive Agreement

INCLUSION OF WOMEN I N STUDY POPULATIONS: A p p l i c a n t s a re urged t o c o n s i d e r t h e i n c l u s i o n o f women i n t h e s t u d y p o p u l a t i o n s f o r a l l c l i n i c a l r e s e a r c h e f f o r t s . Excep t ions would be s t u d i e s o f d i s e a s e s t h a t e x c l u s i v e l y a f f e c t males or where involvement o f p regnan t women may expose t h e f e t u s t o undue r i s k s . Gender d i f f e r e n c e s shou ld be no ted and e v a l u a t e d . If women are n o t t o be inc luded , a c lear r a t i o n a l e shou ld be provided f o r t h e i r e x c l u s i o n .

I n o r d e r t o p r o v i d e more prec ise in fo rma t ion t o t h e t r e a t m e n t community, it is recommended t h a t p u b l i c a t i o n s r e s u l t i n g from ADAMHA-supported r e s e a r c h i n which t h e s t u d y p o p u l a t i o n was l i m i t e d t o one s e x f o r any r e a s o n o t h e r t h a n t h a t t h e d i s e a s e or c o n d i t i o n s t u d i e s e x c l u s i v e l y a f f e c t s t h a t sex , shou ld s t a t e , i n t h e a b s t r a c t summary, t h e gender o f t h e p o p u l a t i o n s t u d i e d , e . g . ,"male p a t i e n t s , " "male vo lun tee r s ,11 "female p a t i e n t s , " "female v o l u n t e e r s .I1

INCLUSION OF MINORITIES I N STUDY POPULATIONS: A p p l i c a n t s are urged t o g i v eadded a t t e n t i o n (where f e a s i b l e and a p p r o p r i a t e ) t o t h e i n c l u s i o n o f m i n o r i t i e s i n s t u d y p o p u l a t i o n s f o r r e s e a r c h i n t o t h e e t i o l o g y o f d i s e a s e s , r e s e a r c h i n b e h a v i o r a l and s o c i a l s c i e n c e s , c l i n i c a l s t u d i e s o f t r e a t m e n t and t r e a t m e n t outcomes, r e s e a r c h on t h e dynamics o f h e a l t h care and i ts impact on d i s e a s e , and a p p r o p r i a t e i n t e r v e n t i o n s f o r d i s e a s e p r e v e n t i o n and h e a l t h promotion. If m i n o r i t i e s are n o t i nc luded i n a g iven s t u d y , a clear r a t i o n a l e for t h e i r e x c l u s i o n shou ld be p rov ided .

APPLICATION PROCESS

A p p l i c a n t s shou ld u s e g r a n t a p p l i c a t i o n form PHS 398 (Rev. 10 /88 ) . The number (DA-90-12) and t i t l e o f t h i s RFA, "Cooperat ive Agreement f o r a R e s i d e n t i a l Drug Abuse Treatment Research Demonstration Program i n t h e D i s t r i c t o f Columbia," shou ld be typed i n i t e m 2 on t h e face page o f PHS 398 form. A p p l i c a n t s must a f f i x t h e RFA l a b e l , which i s p rov ided i n t h e PHS 398 a p p l i c a t i o n k i t , t o t h e bottom o f t h e face page o f t h e a p p l i c a t i o n . F a i l u r e t o u s e t h i s l a b e l cou ld r e s u l t i n delayed p r o c e s s i n g o f t h e a p p l i c a t i o n s o t h a t it may n o t r e a c h t h e review committee i n t i m e f o r r ev iew.

A p p l i c a t i o n k i t s c o n t a i n i n g t h e n e c e s s a r y forms may be o b t a i n e d from b u s i n e s s o f f i c e s o r o f f i c e s o f sponsored r e s e a r c h a t most u n i v e r s i t i e s , c o l l e g e s , medical s c h o o l s , and o t h e r major r e s e a r c h f a c i l i t i e s . If such a s o u r c e i s n o t a v a i l a b l e , t h e f o l l o w i n g o f f i c e may be c o n t a c t e d �or t h e n e c e s s a r y a p p l i c a t i o n material: Gran t s Management Branch, Na t iona l I n s t i t u t e on Drug Abuse, 5600 F i s h e r s Lane, Room 8A-54, R o c k v i l l e , Maryland 20857, ( 3 0 1 ) 443-6710.

P r o s p e c t i v e a p p l i c a n t s are asked t o submit a l e t t e r o f i n t e n t . T h i s shou ld be b r i e f b u t i n d i c a t e t h e P r i n c i p a l I n v e s t i g a t o r and C o - I n v e s t i g a t o r s , and shou ld i d e n t i f y c o o p e r a t i n g i n s t i t u t i o n s , i f any. The I n s t i t u t e r e q u e s t s such l e t t e r s o n l y f o r t h e purpose o f p r o v i d i n g an i n d i c a t i o n of t h e number and scope of a p p l i c a t i o n s t o be r e c e i v e d and, t h e r e f o r e , u s u a l l y does not acknowledge t h e i r r e c e i p t . A l e t t e r of i n t e n t is n o t b ind ing and w i l l n o t en te r i n t o t h e review o f any a p p l i c a t i o n subsequen t ly submi t t ed , n o r i s it a n e c e s s a r y requirement f o r a p p l i c a t i o n s . T h i s l e t t e r o f i n t e n t , which shou ld be r e c e i v e d by May 12, 1990, should be s e n t t o :

D r . Michael S . Backenheimer Act ing D i r e c t o r , O f f i c e o f Extramural Program Review N a t i o n a l I n s t i t u t e o f Drug Abuse 5600 F i s h e r s Lane, Room 10-42 R o c k v i l l e , MD 20857

The s i g n e d o r i g i n a l and 5 permanent, l e g i b l e c o p i e s o f t h e completed a p p l i c a t i o n shou ld be s e n t t o :

D i v i s i o n o f Research Gran t s N a t i o n a l I n s t i t u t e s o f H c a l t h Westwood Bu i ld ing , Room 240 Bethesda, MD 20892x3

It i s sugges t ed t h a t a copy o f t h e a p p l i c a t i o n a l s o be sent s e p a r a t e l y t o D r . Michael Backenheimer, a t t h e a d d r e s s shown above, so t h a t a t i m e l y review maybc a r r a n g e d .

REVIEW PROCESS

The D i v i s i o n o f Research Gran t s , N I H , s e r v e s as a c e n t r a l p o i n t �or r e c e i p t of a p p l i c a t i o n s f o r most d i s c r e t i o n a r y PHS g r a n t programs. A p p l i c a t i o n s r e c e i v e d

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under t h i s RFA w i l l b e a s s i g n e d t o a n I n i t i a l Review Group ( I R G ) i n accordance w i t h e s t a b l i s h e d PHS Referral G u i d e l i n e s . The I R G s , c o n s i s t i n g p r i m a r i l y of non-Federal s c i e n t i f i c and t e c h n i c a l e x p e r t s , w i l l review t h e a p p l i c a t i o n s f o r s c i e n t i f i c and t e c h n i c a l m e r i t . N o t i f i c a t i o n of t h e review recommendations w i l l b e s e n t t o t h e a p p l i c a n t a f te r t h e i n i t i a l r ev iew. A p p l i c a t i o n s w i l l r e c e i v e a second- l eve l review by t h e Na t iona l Advisory Counci l on Drug Abuse whose review may be based on p o l i c y c o n s i d e r a t i o n s as w e l l as s c i e n t i f i c meri t . Only a p p l i c a t i o n s recommended f o r approva l by t h e Counci l may be c o n s i d e r e d f o r f u n d i n g .

INTERGOVERNMENTAL REVIEW

The in t e rgove rnmen ta l review requ i r emen t s o f Execu t ive Order 12372, as implemented th rough DHHS r e g u l a t i o n s a t 45 CFR P a r t 1 0 0 , a r e a p p l i c a b l e t o a p p l i c a t i o n s submi t t ed i n r e sponse t o t h i s RFA. Through t h i s p r o c e s s , S t a t e s , i n c o n s u l t a t i o n w i t h l o c a l governments ( o r i n t h i s case, t h e D . C . Government), are p rov ided t h e o p p o r t u n i t y t o review and comment on a p p l i c a t i o n s f o r F e d e r a l f i n a n c i a l a s s i s t a n c e . A p p l i c a n t s shou ld c o n t a c t t h e District o f Columbia S i n g l e P o i n t o f Con tac t (SPOC) l i s t e d below as e a r l y as p o s s i b l e t o de t e rmine t h e a p p l i c a b l e p rocedure : M s . Love t t a Davis , D . C . S t a t e S i n g l e P o i n t o f Contac t , Execu t ive Off ice o f t h e Mayor, Office o f In t e rgove rnmen ta l R e l a t i o n s , Room 416, Dis t r ic t B u i l d i n g , 1350 Pennsy lvan ia Avenue, N . W . , Washington, D . C . 20004, Telephone: (202) 727-9111.

AVAILABILITY OF FUNDS

I n FY 1990, it i s e s t i m a t e d t h a t $2.0 m i l l i o n t o $ 2 . 5 m i l l i o n w i l l be a v a i l a b l e t o s u p p o r t one award under t h i s RFA ( i n c l u d i n g d i r e c t and i n d i r e c t c o s t s 1 .

INQUIRIES

F u r t h e r i n f o r m a t i o n about t h i s p r o j e c t may be o b t a i n e d from:

Frank M . T i m s , Ph.D. Deputy Ch ie f , . Treatment Research Branch D i v i s i o n o f C l i n i c a l Research, N I D A 5600 F i s h e r s Lane, Room 10A-30 R o c k v i l l e , MD 20857 Telephone: (301 1 443-4060

CANCER PREVENTION AND C L I N I C A L RESEARCH I N UNDER-SERVED POPULATIONS

RFA AVAILABLE: CA-90-14

P.T. 34, FF; K.W. 0715035, 0785035, 0745027, 0745035, 0795003, 0710030

N a t i o n a l Cancer I n s t i t u t e

Le t t e r o f I n t e n t Rece ip t Date: May 15, 1990 A p p l i c a t i o n R e c e i p t Date: August 8, 1990

The S p e c i a l P o p u l a t i o n s S t u d i e s Branch o f t h e D i v i s i o n o f Cancer P r e v e n t i o n and C o n t r o l , N a t i o n a l Cancer I n s t i t u t e ( N C I ) , announces t h e a v a i l a b i l i t y o f a Request f o r A p p l i c a t i o n s (RFA) on t h e above s u b j e c t . Awards w i l l n o t be made t o f o r e i g n i n s t i t u t i o n s .

The D i v i s i o n o f Cancer P r e v e n t i o n and Con t ro l IDCPC), N C I , i n v i t e s g r a n ta p p l i c a t i o n s from i n v e s t i g a t o r s i n t e r e s t e d i n conduc t ing a c o o r d i n a t e d and s y s t e m a t i c program i n c a n c e r p r e v e n t i o n and c l i n i c a l r e s e a r c h f o r under-served p o p u l a t i o n s . The term “under-served p o p u l a t i o n s ” refers t o t h o s e p o p u l a t i o n segments t h a t may e x p e r i e n c e , o r are known t o e x p e r i e n c e , h i g h e r t h a n ave rageU . S . g e n e r a l p o p u l a t i o n c a n c e r ra tes and are under-served i n terms o f access t o q u a l i t y comprehensive c a n c e r p r e v e n t i o n , s c r e e n i n g and e a r l y d e t e c t i o n , and t r e a t m e n t s e r v i c e s .

The g o a l o f a c a n c e r c o n t r o l and p r e v e n t i o n r e s e a r c h program f o r under-served p o p u l a t i o n s is t o p r o v i d e a mechanism t o a l l o w t h e implementat ion o f a s y s t e m a t i c and c o o r d i n a t e d r e s e a r c h e f f o r t t o r educe c a n c e r i n c i d e n c e ,m o r t a l i t y and t o improve s u r v i v a l ra tes i n under-served low-income h i g h - r i s kp o p u l a t i o n s . By r a p i d d i s s e m i n a t i o n o f s t a t e - o f - t h e - a r t cance r p r e v e n t i o n and c o n t r o l t echno logy a s i g n i f i c a n t effect can be ach ieved i n r educ ing cance r m o r t a l i t y i n m i n o r i t y and under-served p a t i e n t s t h rough i n c r e a s e d a c c r u a l t o c l i n i c a l t r i a l s and p a r t i c i p a t i o n i n s c r e e n i n g and e a r l y d e t e c t i o n programs.

The term “under-served p o p u l a t i o n s ” refers t o t h o s e p o p u l a t i o n segments t h a t may e x p e r i e n c e , o r are known t o e x p e r i e n c e , h i g h e r t h a n U.S. g e n e r a l

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W

p o p u l a t i o n cance r r a t e s and are under-served i n terms o f access t o q u a l i t ycomprehensive cance r p r e v e n t i o n , s c r e e n i n g and e a r l y d e t e c t i o n , and treatment s e r v i c e s . Under-served p o p u l a t i o n s may i n c l u d e , bu t are n o t l i m i t e d t o , g roups wi th c o n c e n t r a t i o n s o f i n d i v i d u a l s w i th low-income, Blacks , H i span ic s ,Asian r e f u g e e s , American I n d i a n s , e l d e r l y , Hawaiian Na t ives , and Alaskan N a t i v e s . They may a l s o i n c l u d e communities where comprehensive cance r s e r v i c e s a r e u n a v a i l a b l e whether t h e communities a r e i n urban c e n t e r s or i n r u r a l a r e a s . Cons ide ra t ion should be g iven t o an adequate r e p r e s e n t a t i o n o f women w i t h i n t h e s e groups .

Reques ts f o r c o p i e s o f t h e RFA should be addres sed t o :

Chief S p e c i a l Popu la t ions S t u d i e s Branch D i v i s i o n o f Cancer P reven t ion and Con t ro l N a t i o n a l Cancer I n s t i t u t e Execut ive P laza North (EPN), Room 240 9000 Rockv i l l e P ike Bethesda, PID 20892-4200 Telephone: ( 3 0 1 ) 496-8589

BEHAVIORAL RESEARCH I N SUPPORT OF AIDS PREVENTION

RFA AVAILABLE: NR-90-02

P.T. 34; K . W . 0715008, 0404000, 0745027, 0411005, 0404009

N a t i o n a l I n s t i t u t e s o f Hea l th

A p p l i c a t i o n Rece ip t Date: J u l y 10, 1990

Purpose

The Agency f o r I n t e r n a t i o n a l Development ( A . I . D ) , t h e N a t i o n a l Center for Nursing Research ( N C N R ) , t h e Na t iona l I n s t i t u t e on Aging ( N I A ) , and t h e Na t iona l I n s t i t u t e o f Ch i ld Hea l th and Human Development ( N I C H D ) , i n c o n s u l t a t i o n wi th t h e Na t iona l I n s t i t u t e s o f Hea l th Office o f AIDS Research ( O A R ) and t h e Fogar ty I n t e r n a t i o n a l Center (F IC) , i n v i t e a p p l i c a t i o n s f o r b a s i c r e s e a r c h p r o j e c t s t h a t w i l l p rov ide in fo rma t ion conce rn ing h i g h - r i s kb e h a v i o r s and b e h a v i o r a l changes r e l a t i n g t o t h e t r a n s m i s s i o n o f Human Immunodeficiency V i r u s ( H I V ) th roughout t h e l i f e cour se ; and s t r e n g t h e ndeveloping-count ry c a p a b i l i t i e s t o des ign and c a r r y o u t b e h a v i o r a l r e s e a r c h t o reduce t r a n s m i s s i o n o f Human Immunodeficiency V i r u s ( H I V ) i n f e c t i o n .

SCOPE

Research under t h i s Request f o r A p p l i c a t i o n s (RFA) shou ld be t h e o r e t i c a l l ygrounded and conducted i n c o l l a b o r a t i o n wi th deve loping c o u n t r y c o u n t e r p a r t s .Research a r e a s i n c l u d e : s t u d i e s o f m u l t i p l e - p a r t n e r behav io r which would h e l p t o d e f i n e t h e de t e rminan t s , f requency , and d i s t r i b u t i o n o f such behav io r and i d e n t i f y t h o s e aspects of t h e behav io r t h a t are most amenable t o s u s t a i n a b l e change; s t u d i e s of i n t r a v e n o u s d rug use t h a t would h e l p t o d e f i n e t h e c o n t e x t of drug u s e , p a r t i c u l a r l y w i t h r e s p e c t t o need le - sha r ing behav io r s , and t h e r e l a t i o n s h i p s between d rug u s e and s e x u a l t r a n s m i s s i o n ; s t u d i e s o f u s e o f condoms and/or spe rmic ides f o r AIDS p r e v e n t i o n t h a t would d e f i n e a t t i t u d e s and p r a c t i c e s r e l a t e d t o such u s e , p a r t i c u l a r l y i n v a r i o u s c u l t u r a l c o n t e x t s ; and s t u d i e s o f c u l t u r a l p r a c t i c e s t h a t may enhance t h e r i s k o f s e x u a l t r a n s m i s s i o n , a l t e r t h e p r o t e c t i o n o f f e r e d by condoms, o r may affect t h e a b i l i t y t o s u s t a i n r i s k - r e d u c i n g b e h a v i o r s . S t u d i e s shou ld s e e k t o i d e n t i f yapproaches t o behav io r change.

Study p o p u l a t i o n s shou ld i n c l u d e t h o s e most l i k e l y t o be p r a c t i c i n g h i g h - r i s kbehav io r s i n s e l e c t e d developing c o u n t r i e s i n c l u d i n g i n d i v i d u a l s wi th m u l t i p l es e x u a l p a r t n e r s , i n t r a v e n o u s drug u s e r s and t h e i r s e x u a l and need le - sha r ing p a r t n e r s , s e x u a l p a r t n e r s o f pe r sons r e c e i v i n g contaminated blood o r blood p roduc t s , p a t i e n t s from s e x u a l l y t r a n s m i t t e d d i s e a s e c l i n i c s , o r o t h e r s whose b e h a v i o r s p l a c e them a t h i g h r i s k f o r s e x u a l l y t r a n s m i t t i n g H I V i n f e c t i o n or becoming i n f e c t e d . Research t o i d e n t i f y o t h e r undef ined r i s k groups and r e l a t e d b e h a v i o r s shou ld be inc luded . Where f e a s i b l e and a p p r o p r i a t e , a t t e m p t s should be made t o i n s u r e t h a t s t u d y p o p u l a t i o n s i n c l u d e t h e f u l l spectrum o f HIV-infected i n d i v i d u a l s o f t h e s p e c i f i c c u l t u r e where t h e s t u d yi s proposed .

S t u d i e s a r e encouraged t h a t i n c o r p o r a t e i n n o v a t i v e r e s e a r c h methods such as improvements i n methods f o r a s s e s s i n g b e h a v i o r a l de t e rminan t s , f o r mon i to r ing p a t t e r n s o f r i s k behav io r and behav io r change, f o r c o l l e c t i n g and v a l i d a t i n gs e l f - r e p o r t e d b e h a v i o r a l d a t a , and f o r e v a l u a t i n g t h e e f f e c t i v e n e s s o f i n t e r v e n t i o n a c t i v i t i e s .

N I H G U I D E - Vol. 19, No. 13, March 30, 1990 - Page 7

The p r o j e c t s w i l l b e s i n g l e p r o j e c t s t h a t c o n s i s t o f a c t i v i t i e s t o t a k e p l a c e i n two p h a s e s . Phase I w i l l c o n s i s t o f a p r e l i m i n a r y f e a s i b i l i t y s t u d y f o r t h e l a r g e r body of work t o be unde r t aken i n Phase 11. It i s expec ted t h a t Phase I fund ing w i l l be f o r up t o 12 months, and Phase I1 fund ing w i l l be f o r up t o t h r e e a d d i t i o n a l y e a r s . Each Phase shou ld have we l l -de f ined g o a l s , o b j e c t i v e s , and o u t p u t s . Awardees w i l l develop a working r e l a t i o n s h i p w i t h a deve lop ing c o u n t r y c o u n t e r p a r t d u r i n g Phase I and w i l l a l s o e s t a b l i s h t h e t e c h n i c a l and s c i e n t i f i c f e a s i b i l i t y o f s u c c e s s f u l complet ion o f t h e e n t i r e p r o j e c t . MECHANISM AND SCALE OF SUPPORT

Support f o r t h i s program w i l l b e d i v i d e d by phase . Phase I w i l l b e funded byA . I . D . t h rough Family H e a l t h I n t e r n a t i o n a l (FHI) , and s u p p o r t f o r Phase I1 w i l l b e e i t h e r by g r a n t s from t h e I n s t i t u t e s o r C e n t e r s o f t h e N a t i o n a l I n s t i t u t e s o f H e a l t h ( N I H ) o r by A . I . D . t h r o u g h FHI. Awards made by t h e N I H w i l l b e a d m i n i s t e r e d under PHS g r a n t s p o l i c y as s t a t e d i n t h e P u b l i c Hea l th S e r v i c e Gran t s P o l i c y S ta t emen t , DHHS P u b l i c a t i o n No. (OASH) 82-50,000,r e v i s e d J a n u a r y 1, 1987.

It is n o t expec ted t h a t a l l o f t h e awarded Phase I s t u d i e s w i l l b e extended i n t o Phase 11. Ex tens ion w i l l b e based on s u c c e s s i n Phase I ; review procedures and c r i t e r i a f o r e x t e n s i o n are d e s c r i b e d i n t h e RFA. Funding of Phase I1 s t u d i e s w i l l a l s o be based on programmatic r e l e v a n c e t o a p a r t i c u l a r fund ing agency.

Up t o approx ima te ly s i x p i l o t s t u d i e s i n Phase I w i l l b e funded ($50,000 t o $85,000 o f t o t a l c o s t s f o r up t o 12 months) . The a n t i c i p a t e d fund ing l e v e l f o r Phase I1 for t h o s e s t u d i e s approved f o r c o n t i n u a t i o n i s $150,000 t o $200,000 p e r y e a r f o r up t o t h r e e a d d i t i o n a l y e a r s f o r t o t a l ( d i r e c t and i n d i r e c t ) c o s t s . It i s expec ted t h a t up t o s i x Phase I1 p r o j e c t s w i l l b e funded. A l l awards under t h i s RFA are c o n t i n g e n t on t h e a v a i l a b i l i t y of funds , and t h e spec i f i c amount t o be awarded w i l l depend on t h e merit and scope o f t h e a p p l i c a t i o n s received.

APPLICATION

A p p l i c a n t s shou ld submit a s i n g l e p r o p o s a l f u l l y d e s c r i b i n g r e s e a r c h a c t i v i t i e s f o r b o t h Phase I and Phase 11. P o t e n t i a l a p p l i c a n t s are a d v i s e d t o o b t a i n t h e f u l l RFA and a n a p p l i c a t i o n package from:

M s . Nancy HardyFamily Hca l th I n t e r n a t i o n a l 1611 N . Kent S t r e e t S u i t e 903 Rosslyn, VA 22209-2169 Telephone : (7031 243-8510

PERINATAL BEHAVIORAL DEVELOPMENT

RFA AVAILABLE: 90-HD/MH-08

P.T. 34; K . W . 0715020, 0775000, 0414012, 0404004, 0755020

N a t i o n a l I n s t i t u t e of Ch i ld Hea l th and Human DevelopmentN a t i o n a l I n s t i t u t e o f Mental Hea l th

A p p l i c a t i o n Rece ip t Date: J u l y 31, 1990

The Human Learning and Behavior Branch o f t h e Cen te r f o r Research f o r Mothers and C h i l d r e n o f t h e N a t i o n a l I n s t i t u t e o f Ch i ld Hea l th and Human Development( N I C H D ) , N a t i o n a l I n s t i t u t e s o f Hea l th ( N I H ) , and t h e Behav io ra l S c i e n c e s Research Branch o f t h e D i v i s i o n o f Basic B r a i n and Behav io ra l S c i e n c e s o f t h e N a t i o n a l I n s t i t u t e of Mental Hea l th ( N I M H ) , Alcohol , Drug Abuse, and Mental Hea l th A d m i n i s t r a t i o n (ADAMHA), j o i n t l y i n v i t e i n v e s t i g a t o r - i n i t i a t e d r e s e a r c h a p p l i c a t i o n s ( R o l l t o develop new methods, t h e o r i e s , and knowledge on a s p e c t sof b e h a v i o r a l development d u r i n g t h e p e r i n a t a l p e r i o d . The a i m i s t o encourage p s y c h o b i o l o g i c a l s t u d i e s , t h e o r e t i c a l l y e m p i r i c a l l y based, t h e

1 1 4 -

o r on ontogeny o f behav io r ( e . g . , l e a r n i n g , memory, m o t i v a t i o n , a t t achmen t , and senso r imoto r f u n c t i o n i n g ) d u r i n g t h e p r e n a t a l and e a r l y p o s t n a t a l p e r i o d s .Major f o c i are upon t h e use o f animal models and i n t e r d i s c i p l i n a r ymethodo log ica l approaches . S e l e c t e d s t u d i e s o f human p e r i n a t e s w i l l a l s o be c o n s i d e r e d . Up t o s i x a p p l i c a t i o n s may be funded i n connec t ion w i t h t h i s Request f o r A p p l i c a t i o n s (RFA).

T h i s program i s d e s c r i b e d i n t h e Catalogue o f Domestic A s s i s t a n c e number 13.865, Research f o r Mothers and C h i l d r e n and 13.242, D i v i s i o n o f Bas i c B r a i n

N I H GUIDE - Vol. 19, No. 13, March 3 0 , 1990 - Page 8

and Behav io ra l S c i e n c e s . Awards w i l l b e made under t h e a u t h o r i t y o f t h e P u b l i c Hea l th S e r v i c e A c t , T i t l e 11, S e c t i o n 301 ( P u b l i c Law 78-410, as amended; 42 USC 241) and a d m i n i s t e r e d under PAS g r a n t p o l i c i e s and F e d e r a l R e g u l a t i o n s 42 CRF p a r t 52 and 45 CRF 74. T h i s program i s n o t s u b j e c t t o t h e in t e rgove rnmen ta l review requ i r emen t s o f Execu t ive o r d e r 12372 o r Hea l th Systems Agency Review.

W I n q u i r i e s shou ld be d i r e c t e d t o :

Norman A . Krasnegor, Ph.D. C h i e f , Human Learning and Behavior Branch N a t i o n a l I n s t i t u t e o f C h i l d Hea l th and Human DevelopmentExecu t ive P l a z a North, Room 633 9000 R o c k v i l l e P i k e Bethesda, MD 20892 Telephone : ( 3 0 1 1 496-6591

OR

Rodney Cocking, Ph .D . Act ing C h i e f , Behav io ra l S c i e n c e s Research Branch N a t i o n a l I n s t i t u t e o f Ment a 1 Hea l th Parklawn B u i l d i n g , Room 11C10 5600 F i s h e r s Lane R o c k v i l l e , MD 20857 Telephone: ( 3 0 1 ) 443-3566

O N G O I N G PROGRAM ANNOUNCEMENTS

ADAMHA SMALL INSTRUMENTATION GRANT PROGRAM

P.T. 18; K.W. 0735000

Alcohol , Drug Abuse, and Mental Hea l th A d m i n i s t r a t i o n

A p p l i c a t i o n Rece ip t Date: June 1 , 1990

The Alcohol , Drug Abuse, and Mental Hea l th A d m i n i s t r a t i o n (ADAMHA) i s announcing t h e second y e a r o f t h e ADAMHA Small I n s t r u m e n t a t i o n Program (ASIP) .These g r a n t s r e a u t h o r i z e d by Congress f o r FY 1990 i n S e c t i o n 5 0 1 ( m ) o f t h e P u b l i c Hea l th S e r v i c e A c t , as added t o by P . L . 100-690, i n r e sponse t o f i n d i n g s t h a t much o f t h e r e s e a r c h i n s t r u m e n t a t i o n i n t h e N a t i o n ' s p r i n c i p a lu n i v e r s i t i e s i s e i t h e r o b s o l e t e or p o o r l y ma in ta ined . Thesc f i n d i n g s ,documented i n s e v e r a l r e p o r t s , i d e n t i f i e d t h e need f o r upgrading equipmentc u r r e n t l y i n u s e . The most s i g n i f i c a n t nced w a s f o r r e l a t i v e l y low-cost p i e c e s o f equipment. To a d d r e s s t h i s problem, ADAMHA e s t a b l i s h e d t h e Small I n s t r u m e n t a t i o n Program i n FY 1989. Awards a r e made under a u t h o r i t y o f T i t l e s I11 and V o f t h e PHS A c t as amended. Funds w i l l b e p rov ided t o r e s e a r c h - i n t e n s i v e i n s t i t u t i o n s c u r r e n t l y r e c e i v i n g ADAMHA r e s e a r c h support.The ASIP i s n o t i n t e n d e d t o r e p l a c e r e q u e s t s f o r equipment i n a p p l i c a t i o n s f o r i n d i v i d u a l r e s e a r c h p r o j e c t s . Ra the r , it i s in t ended t o h e l p fund items o f equipment t h a t are d i f f i c u l t t o j u s t i f y w i t h i n t h e c o n t e x t o f an i n d i v i d u a l r e s e a r c h p r o j e c t b u t t h a t w i l l upgrade t h e i n s t i t u t i o n ' s r e s e a r c h i n f r a s t r u c t u r e .

The ADAMHA program h a s a similar purpose t o t h e N a t i o n a l I n s t i t u t e s o f Hea l th Small I n s t r u m e n t a t i o n Program b u t w i l l o p e r a t e s e p a r a t e l y and under s l i g h t l yd i f f e r e n t g u i d e l i n e s because o f d i f f e r e n c e s i n t h e i n f z a s t r u c t u r e suppor tmechanisms a v a i l a b l e t o t h e two a g e n c i e s .

The ADAMHA program w i l l be funded i n FY 1990 a t $2,790,000. The programp r o v i d e s awards r a n g i n g from $ 2 0 , 0 0 0 t o $ 1 0 0 , 0 0 0 t o e l i g i b l e i n s t i t u t i o n s . E l i g i b l e i n s t i t u t i o n s a re t h o s e t h a t had f i v e or more a c t i v e ADAMHA r e s e a r c h o r c a r e e r g r a n t s awarded i n FY 1989. A t l e a s t one o f t h e awards m u s t be from t h e f o l l o w i n g t y p e s o f developmental awards: R03, R23, R29, K07, K 0 8 , K 1 1 , K20. The remaining awards may be from t h i s l i s t o f g r a n t mechanisms o r may be R01 o r R37 g r a n t s t o make t h e t o t a l o f f i v e g r a n t awards needed f o r e l i g i b i l i t y . The amount f o r which your i n s t i t u t i o n may app ly w a s c a l c u l a t e d by a formula based on t h e $ 2 , 7 9 0 , 0 0 0 a v a i l a b l e f o r t he program t h i s y e a r and on t h e number o f ADAMHA-sponsored awards i n t h e e l i g i b l e mechanisms a t youri n s t i t u t i o n . Each e l i g i b l e i n s t i t u t i o n may submit ONLY O N E a p p l i c a t i o n t h a t i n c o r p o r a t e s a l l a p p r o p r i a t e equipment r e q u e s t s from t h a t i n s t i t u t i o n . Thus,it is e s s e n t i a l t h a t i n s t i t u t i o n a l o f f i c i a l s p u b l i c i z e t h e a v a i l a b i l i t y of ASIP funds so t h a t ADANHA-supported i n v e s t i g a t o r s i n need o f sma l l r e s e a r c h i n s t r u m e n t s a r e p rov ided t h e o p p o r t u n i t y t o i n d i c a t e t h c i r needs f o r such equipment t o t h e a p p r o p r i a t e i n s t i t u t i o n a l o f f i c i a l .

N I H GUIDE - Vol. 19, No. 13, March 3 0 , 1990 - Page 9

The equipment r e q u e s t e d m u s t b e a v a i l a b l e f o r u s e by more t h a n one p r o j e c te i t h e r c u r r e n t l y o r i n t h e f u t u r e . The pr imary u s e r ( s ) o f t h e equipment must be one o r more p r i n c i p a l i n v e s t i g a t o r s o f a c t i v e ADAMHA-supported r e s e a r c h g r a n t s , and t h e spec i f i c p r o j e c t s must be c i t e d i n t h e a p p l i c a t i o n .I n s t i t u t i o n s are s t r o n g l y urged t o i n c l u d e t h e l i s t e d career developmentalp r o j e c t s ( i . e . , a l l t h o s e o t h e r t h a n R 0 1 and R 3 7 g r a n t s ) i n t h e u s e o f t h e equipment. No i n d i r e c t c o s t s w i l l b e p rov ided and t h e r e w i l l b e no f u t u r e y e a r funding commitment. The r e q u e s t e d funds may be f o r f u l l o r p a r t i a l s u p p o r t of one o r more p i e c e s o f equipment. I n no case, however, may t h e t o t a l pu rchase p r i c e o f a r e q u e s t e d p i e c e o f equipment be less t h a n $5,000 o r more t h a n $100,000 r e g a r d l e s s o f t h e s o u r c e ( s ) o f fund ing . If t h e t o t a l d o l l a r amount o f proposed equipment pu rchases exceeds t h e amount f o r which t h e i n s t i t u t i o n i s e l i g i b l e , a s t a t e m e n t m u s t be submi t t ed which i n d i c a t e s t h a t t h e i n s t i t u t i o n w i l l p r o v i d e t h e d i f f e r e n c e . Support from t h i s program cannot be used t o pu rchase i tems exceeding $100,000 i n c o s t even i f c o s t s a r e s h a r e d . The equipment purchased must be t h e same as t h a t s p e c i f i e d i n t h e ASIP a p p l i c a t i o n .

A p p l i c a t i o n s must be r e c e i v e d by June 1, 1990. D e t a i l e d a p p l i c a t i o np r o c e d u r e s have been s e n t t o e l i g i b l e i n s t i t u t i o n s . A p p l i c a t i o n s w i l l be p e e rreviewed by a s i n g l e ADAMHA-wide committee. The review c r i t e r i a are: Degreeo f adhe rence t o t h e terms o f t h e l e t t e r o f e l i g i b i l i t y and adequacy o f t h e j u s t i f i c a t i o n p rov ided f o r t h e equipment r e q u e s t e d . The r e v i e w e r s w i l l d e t e rmine whether o r n o t t h e a p p l i c a t i o n i s recommended f o r a p p r o v a l ; no p r i o r i t y s c o r e s w i l l b e v o t e d . A p p l i c a t i o n s w i l l be a s s i g n e d t o i n d i v i d u a l ADAMHA I n s t i t u t e s f o r c o n s i d e r a t i o n by t h e i r N a t i o n a l Advisory Counc i l s and f o r fund ing . The I n s t i t u t e s expec t t o make t h e awards i n September.

Q u e s t i o n s conce rn ing t h i s program may be d i r e c t e d t o any o f t h e f o l l o w i n g p e r s o n s :

D r . Les l ie Isaki D i v i s i o n o f Basic Research N a t i o n a l I n s t i t u t e on Alcohol Abuse Room 14C-20 Telephone: (301 ) 443-4223

D r . Stephen S z a r a D i v i s i o n of P r e c l i n i c a l Research N a t i o n a l I n s t i t u t e on Drug Abuse Room 10A-31 Telephone: (301 1 443-6300

M r . James MoynihanD i v i s i o n o f Bas i c B r a i n and Behav io ra l

and Alcoholism

S c i e n c e s N a t i o n a l I n s t i t u t e o f Mental Hea l th Room 11-95 Telephone: (301) 443-3107

The m a i l i n g a d d r e s s f o r t h e above i n d i v i d u a l s is:

5600 F i s h e r s Lane R o c k v i l l e , MD 20857

SPECIAL EMPHASIS RESEARCH CAREER AWARD I N LABORATORY ANIMAL SCIENCE

P.T. 34; K.W. 0201058, 1002027, 0765035, 1002019, 0710070, 1003002

N a t i o n a l Cen te r f o r Research Resources

A p p l i c a t i o n Rece ip t Date: June 1, 1990

T h i s i s t o announce some m o d i f i c a t i o n s and c l a r i f i c a t i o n s t o t h e g u i d e l i n e s f o r t h e S p e c i a l Emphasis Research Career Award (SERCA) i n Labora to ry Animal S c i e n c e s , most r e c e n t l y announced by t h e N a t i o n a l Cen te r f o r Research Resources ( f o r m e r l y D i v i s i o n o f Research Resources ) i n 1989. A summary of t h e s e changes is g i v e n below. Note t h a t t h e r e i s a s i n g l e r e c e i p t d a t e .

AREAS OF CHANGE

1 . The r equ i r emen t f o r p r i o r t r a i n i n g l e x p e r i e n c e h a s been i n c r e a s e d .

2 . An a p p l i c a n t may be e n r o l l e d i n Ph.D. program.

3. A c t i v i t i e s shou ld be focused on a s p e c i f i c r e s e a r c h area.

N I H G U I D E - V o l . 19, No. 13, March 30, 1990 - Page 10

4. The a p p l i c a n t may n o t have been d e s i g n a t e d p r e v i o u s l y as a P r i n c i p a lI n v e s t i g a t o r on any r e s e a r c h p r o j e c t suppor t ed by s o u r c e s o u t s i d e h i d h e r i n s t i t u t i o n .

5 . The major a d v i s o r and l a b o r a t o r y shou ld be d i f f e r e n t f o r p re -ve r suspost-Ph.D. a c t i v i t i e s .

'W 6 . S p e c i f i c c r i t e r i a f o r review have been i n c l u d e d .

ADMINISTRATIVE REQUIREMENTS. The SERCA award i s a f i v e - y e a r , n o n t r a n s f e r a b l e ,non-renewable award. The maximum s a l a r y from t h i s award may n o t exceed $40,000 a y e a r . F r i n g e b e n e f i t s from t h e award w i l l be based on t h e s a l a r yawarded by N I H . S a l a r y supplements are a l l o w a b l e b u t may n o t be made from o t h e r F e d e r a l s o u r c e s . Thc a p p l i c a n t must a g r e e t o devo te a t l e a s t 75 p e r c e n te f f o r t t o r e s e a r c h . Research suppor t may be r e q u e s t e d up t o t h e amount o f $ 8 , 0 0 0 p e r y e a r f o r t h e f i r s t t h r e e y e a r s and $ 1 5 , 0 0 0 p e r y e a r f o r t h e l a s t two y e a r s . The a p p l i c a n t must a g r e e t o keep t h e Animal Resources ProgramCARP), N a t i o n a l Cen te r f o r Xesearch Resources ( N C R R ) , N a t i o n a l I n s t i t u t e s of Hea l th ( N I H ) , informed o f h i s / h e r r e s e a r c h and t r a i n i n g a c t i v i t i e s f o r a p e r i o d o f f i v e y e a r s f o l l o w i n g complet ion o f t h i s s u p p o r t .

APPLICANT E L I G I B I L I T Y REQUIREMENTS. The a p p l i c a n t must ho ld a degree i n v e t e r i n a r y medicinc (D.V.I.1. , V . M . D . , o r e q u i v a l e n t ) ; be a U.S. c i t i z e n ,n o n c i t i z e n U.S. n a t i o n a l , o r a n o n c i t i z e n who h a s been admi t t ed t o t h e U.S. f o r permanent r e s i d e n c e ; and have a t l ea s t t h r e e y e a r s o f post-D.V.M.e x p e r i e n c e t h a t i n c l u d e s t h e e q u i v a l e n t o f a t l c a s t two y e a r s o f f u l l - t i m e ( 8 0 p e r c e n t FTE) t r a i n i n g and/or e x p e r i e n c e i n c l i n i c a l l a b o r a t o r y animal medicine or compara t ive pa tho logy i n an i n s t i t u t i o n engaged i n biomedical i n v e s t i g a t i o n . The SERCA shou ld n o t be c o n s i d e r e d as a mechanism t o o b t a i n t h e Ph.D. d e g r e e . However, t h e r e s e a r c h performed under t h e SERCA may be used t o s a t i s f y t h e t h e s i s r equ i r emen t s f o r a Ph.D. deg ree a f t e r t h e q u a l i f y i n gexamina t ion h a s been p a s s e d . The a p p l i c a n t may n o t have been a P I on anyr e s e a r c h p r o j e c t suppor t ed by s o u r c e s from o u t s i d e h i s l h e r i n s t i t u t i o n .

PROGRAM REQUIREMENTS. The a p p l i c a n t must propose a s e n i o r s c i e n t i s t , w i t h e x p e r i e n c e i n p o s t - d o c t o r a l t r a i n i n g , as an a d v i s o r t o gu ide t h e f i r s t t h r e e y e a r s o f t h e award p e r i o d . The a d v i s o r must a g r e e t o be a v a i l a b l e t o c o u n s e l ,a d v i s e , and monitor t h e a p p l i c a n t ' s r e s e a r c h a t f r e q u e n t i n t e r v a l s . I n a d d i t i o n , t h r e e l e t t e r s o f r e f e r e n c e are r e q u i r e d from i n v e s t i g a t o r s i n t h e a p p l i c a n t ' s f i e l d o f s c i e n t i f i c i n t e r e s t o r i n a c l o s e l y r e l a t e d f i e l d .

u r ~ D i f f e r e n t a d v i s o r s f o r p r e - and p o s t - Ph.D. work shou ld be i d e n t i f i e d .

I n t h e i n i t i a l a p p l i c a t i o n , t h e a p p l i c a n t and a d v i s o r shou ld d e s c r i b e an o v e r a l l concept o r r e s e a r c h h y p o t h e s i s t h a t w i l l be t h e f o c u s o f t h e award and p r o v i d e t h e framework around which t h e d e s i r e d t r a i n i n g w i l l b e o b t a i n e d . A s p e c i f i c , d e t a i l e d p l a n f o r enhancing t h e a p p l i c a n t ' s r e s e a r c h s k i l l s d u r i n g t h e f i r s t t h r e e y e a r s o f t h e award and a w e l l developed o u t l i n e o f a m e r i t o r i o u s r e s e a r c h program f o r t h e f i n a l two y e a r s o f t h e award must be i n c l u d e d . A s p a r t o f t h e annual p r o g r e s s r e p o r t f o r t h e 03 y e a r , t h e awardee must p r o v i d e a d e t a i l e d r e s e a r c h p l a n f o r t h e l a s t two y e a r s ( y e a r s 04 and 0 5 ) . T h i s p r o p o s a l w i l l b e e v a l u a t e d f o r s c i e n t i f i c m e r i t . T h i s e v a l u a t i o n , a l o n g w i t h t h e p r o g r e s s made th roughou t t h e i n i t i a l t h r e e - y e a r p e r i o d , w i l l b e used t o de t e rmine t h e a p p l i c a n t ' s e l i g i b i l i t y f o r con t inued fund ing f o r t h e f o u r t h and f i f t h y e a r s .

C R I T E R I A FOR REVIEW. I n t h e review o f t h e a p p l i c a t i o n f o r s c i e n t i f i c mer i t , p a r t i c u l a r a t t e n t i o n w i l l b e g iven t o t h e c a n d i d a t e ' s p r i o r t r a i n i n g and e x p e r i e n c e , career p o t e n t i a l , r e s e a r c h career development p l a n s , proposed r e s e a r c h , environment , r e f e r e n c e r e p o r t s , and o t h e r r e l e v a n t i n f o r m a t i o n . The a p p l i c a t i o n must c l e a r l y demons t r a t e t h a t t h e award w i l l enhance t h e c a n d i d a t e ' s development as an independent i n v e s t i g a t o r .

A l e t t e r o f i n t e r e s t t o t h e Branch D i r e c t o r , o u t l i n i n g t h e a p p l i c a n t l s t r a i n i n g , r e s e a r c h i n t e r e s t s , and proposed SERCA program, i s n o t a p r e r e q u i s i t e f o r a p p l y i n g b u t i s encouraged. June 1 w i l l b e t h e o n l y a p p l i c a t i o n r e c e i p t d a t e . D e t a i l e d background i n f o r m a t i o n and a p p l i c a t i o n procedures may be o b t a i n e d from:

D i r e c t o r Labora to ry Animal S c i e n c e s Branch, ARP N a t i o n a l Center f o r Research Resources N a t i o n a l I n s t i t u t e s o f Hea l th Westwood B u i l d i n g , Room 857 5333 Westbard Avenue

, l ~ , Bethesda, PID 20892 Telephone : ( 3 0 1 1 496-51 75

N I H GUIDE - Vol. 19, No. 13, March 3 0 , 1990 - Page 1 1

T h i s program i s d e s c r i b e d i n t h e Ca ta log o f F e d e r a l Domestic A s s i s t a n c e No. 13 .306 , Labora to ry Animal S c i e n c e s and P r ima te Research. Awards w i l l b e made under t h e a u t h o r i t y o f t h e P u b l i c Hea l th S e r v i c e A c t , T i t l e 111, S e c t i o n 301 ( P u b l i c L a w 78-410, a s amended; 42 USC 241) and a d m i n i s t e r e d under PHS g r a n tp o l i c i e s and F e d e r a l R e g u l a t i o n s 4 2 CFR P a r t 52, and 45 CFR P a r t 74. T h i s program i s n o t s u b j e c t t o t h e in t e rgove rnmen ta l review requ i r emen t s o f Execu t ive Order 12372 or H e a l t h Systems Agency r ev iew.

NEUROENDOCRINOLOGY OF HUMAN STRESS

P.T. 3 4 ; K.W. 0785105, 0715195, 0710085, 1002008, 1002004, 1002021, 0710070

N a t i o n a l I n s t i t u t e o f D i a b e t e s , D i g e s t i v e and Kidney Diseases

PURPOSE

The N a t i o n a l I n s t i t u t e o f D i a b e t e s , D i g e s t i v e and Kidney Diseases ( N I D D K )i n v i t e s i n v e s t i g a t o r - i n i t i a t e d r e s e a r c h g r a n t a p p l i c a t i o n s (Ro l l t o advance u n d e r s t a n d i n g o f t h e i n t e r a c t i o n of e n d o c r i n e , c e n t r a l nervous system (CNS),and immunological r e s p o n s e ( s ) t o s t r e s s .

DISCIPLINES AND EXPERTISE

I n t e r d i s c i p l i n a r y approaches may be needed f o r t h i s s t u d y w i t h e x p e r t i s er e q u i r e d i n s e v e r a l o f t h e f o l l o w i n g a r e a s : neuroendocrinology, c e l l and molecular b i o l o g y , h i s t o l o g y , neurophysiology, immunology, and p e p t i d e and/ors t e r o i d b i o c h e m i s t r y .

BACKGROUND

C o r t i c o t r o p i n r e l e a s i n g f a c t o r ( C R F ) i s t h e hypothalamic hormone r e s p o n s i b l ef o r s t i m u l a t i n g t h e r e l e a s e o f p i t u i t a r y p reop iomelanocor t in (POMCI-derivedn e u r o p e p t i d e s , i n c l u d i n g ACTH and E-endorphin. I n a d d i t i o n t o i t s well-known r o l e i n i n i t i a t i n g h y p o t h a l a m i c - p i t u i t a r y - a d r e n a l (HPA) a x i s r e s p o n s e s t o a c u t e s t r e s s and modula-ting long-term a d a p t a t i o n t o c h r o n i c stress, CRF h a s been found t o ac t c ; i t h in o t h e r areas o f t h e CNS t o modulate b e h a v i o r s a s s o c i a t e d w i t h t h e r e sponse and a d a p t a t i o n t o stress. I t h a s been sugges t edt h a t CRF a c t s t o i n t e g r a t e t h e o v e r a l l i n t e r r e l a t e d endoc r ine , n e u r a l , and b e h a v i o r a l r e s p o n s e s t o s t r e s s . I n a d d i t i o n , t h e r e i s p r e l i m i n a r y , b u t p r o v o c a t i v e ev idence f o r b i d i r e c t i o n a l communication between t h e immune, e n d o c r i n e , and c e n t r a l nervous systems mediated by p e p t i d e hormones and r e c e p t o r s common t o t h e s e sys t ems . A v a r i e t y o f n e u r a l c e l l s secrete i n t e r l e u k i n s and growth f a c t o r s , w i t h neu rona l c e l l growth and p r o l i f e r a t i o nr e g u l a t e d by t h e s e monokines and growth f a c t o r s . More r e c e n t l y ev idence h a s been p r e s e n t e d t h a t lymphocytes produce n e u r o p e p t i d e s i n c l u d i n g endorph ins ,enlccphal ins , v a s o a c t i v e i n t e s t i n a l p e p t i d e ( V I P ) , s u b s t a n c e P and c o r t i c o t r o p i n , a l t h o u g h t h e p h y s i o l o g i c a l s i g n i f i c a n c e of t h i s c a p a b i l i t y h a s y e t t o bc e s t a b l i s h e d . These c e l l s a l s o e x p r e s s r e c e p t o r s f o r n e u r o p e p t i d e sand respond t o t h e s e hormones. The same p e p t i d e s may r e g u l a t e p r o d u c t i o n o f c o r t i c o t r o p i n i n lymphocytes and i n t h e p i t u i t a r y . T h e r e f o r e , one element o f t h e immune s y s t e m ' s r e sponse t o s t r e s s e s , such as i n f e c t i o n , inf lammation,t o x i n s , tumors , t r a u m a and p o s s i b l y p s y c h o l o g i c a l stress, may i n v o l v e a c t i v a t i o n o f t h e HPA a x i s a t m u l t i p l e l e v e l s . I t h a s become a p p a r e n t t h a t a c u t e i n f e c t i o n a c t s v i a CRF i n i n i t i a t i n g a c t i v a t i o n o f t h e neu roendocr ine system as p a r t o f t h e r e sponse t o t h i s stress. Recent i n f o r m a t i o n i n d i c a t e s t h a t immune system cy to l t i nes , i n c l u d i n g I L ( i n t e r l u e k i n l - 1 , IL-2, thymosin,and thymopo ie t in , i n t e r a c t a t c e n t r a l hypothalamic and/or a n t e r i o r p i t u i t a r ys i t e s t o r e g u l a t e release o f ACTH wi th consequent e f f ec t s on a d r e n a l g l u c o c o r t i c o i d r e l e a s e . These d a t a have been i n t e r p r e t e d t o s u g g e s t t h a t c y t o k i n e a c t i o n a t t h e l e v e l o f CRF r e l e a s e l i n k s t h e a c u t e r e sponse t o inf lammation t o t h e s t r e s s r e s p o n s e . Many q u e s t i o n s remain, i n c l u d i n g t h a t o f t h e c e l l u l a r and molecu la r mechanisms o f a c t i o n o f CRF on CNS c e n t e r s and t h e r o l e ( s ) and mechanism of a c t i o n o f immune e f f e c t o r s on t h e HPA a x i s and v i c e v e r s a . F i n a l l y , demons t r a t ion o f a c lear b i o l o g i c a l r o l e f o r t h e i n t e r r e l a t i o n s h i p between t h e neu roendocr ine and immune systems remains t o be e s t a b l i s h e d .

OBJECTIVES

T h i s s o l i c i t a t i o n i s in t ended t o s t i m u l a t e r e s e a r c h : 1 ) t h a t w i l l r e s u l t i n new u n d e r s t a n d i n g s o f t h e r o l e o f CRF i n modulat ion o f t h e neu roendocr ine and b e h a v i o r a l r e s p o n s e s t o stress; and 2 ) i n t o t h e i n t e r a c t i o n between t h e immune system and t h e neu roendocr ine system i n med ia t ing t h e endoc r ine r e sponse t o a c u t e and c h r o n i c s t r e s s .

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SCOPE

Some examples o f r e s e a r c h t o p i c s t h a t would be c o n s i d e r e d r e s p o n s i v e t o t h i s s o l i c i t a t i o n i n c l u d e t h e f o l l o w i n g :

s t u d i e s o f t h e c e n t r a l nervous system ef fec ts o f CRF, i n c l u d i n gi d e n t i f i c a t i o n o f t h e c e l l u l a r and neurona l cen te r s /ne tworks t h a t are p a r t o f t h e r e s p o n s e ( s 1 t o CRF.

r e g u l a t i o n o f CRF p r o d u c t i o n and/or release by n e u r o p e p t i d e s and/orimmune e f f e c t o r s .

i d e n t i f i c a t i o n o f t h e s p e c i f i c c e l l s i n t h e hypothalamus and/ora n t e r i o r p i t u i t a r y t h a t respond t o immune e f f e c t o r s and t h e r o l e o f CRF and o t h e r n e u r o p e p t i d e s i n modulat ing t h e r e s p o n s e s o f t h e s e c e l l s .

e l u c i d a t i o n o f t h e mechanism(s) o f r e sponse , i n c l u d i n g r e c e p t o r sinvo lved , s i g n a l t r a n s d u c t i o n pathways, and cy top la smic and/orn u c l e a r r e s p o n s e s o f t h e t a r g e t c e l l s .

effects o f n e u r o p e p t i d e s and immune c e l l e f f e c t o r s on POMC-derived p e p t i d e release from t h e p i t u i t a r y .

e f fec ts o f CRF, ACTH, o r a d r e n a l g l u c o c o r t i c o i d s on immune e f f e c t o r c e l l p r o d u c t i o n and/or release o f modulators .

i d e n t i f i c a t i o n o f t h e n e u r o p e p t i d e s produced i n t h e immune system, as w e l l as c h a r a c t e r i z a t i o n o f neu ropep t ide e f f ec t s on t h e immune system and lymphocyt ic f u n c t i o n s .

e s t a b l i s h m e n t o f t h e f u n c t i o n a l s i g n i f i c a n c e o f CNS and neuroendocr ine involvement i n modulat ion o f t h e immune system and v i c e v e r s a .

These areas of i n t e r e s t are n o t l i s t e d i n any o r d e r o r p r i o r i t y . They are o n l y sugges t ed examples o f areas of r e s e a r c h . A p p l i c a n t s are encouraged t o propose o t h e r areas which are r e l a t e d t o t h e o b j e c t i v e s and scope d e s c r i b e d above.

MECHANISM OF SUPPORT

The mechanism o f s u p p o r t f o r t h i s program w i l l b e t h e g r a n t - i n - a i d . The r e g u l a t i o n s (Code o f F e d e r a l Regu la t ion , T i t l e 42, P a r t 52 and, as a p p l i c a b l e t o t h e s t a t e and l o c a l governments, T i t l e 45, P a r t 74) and p o l i c i e s which govern t h e r e s e a r c h g r a n t programs o f t h e Na t iona l I n s t i t u t e s o f Hea l th w i l l p r e v a i l . Although t h i s s o l i c i t a t i o n is inc luded i n t h e sponsor ing I n s t i t u t e ' s fund ing p l a n s f o r F i s c a l Year 1991, suppor t f o r t h i s s o l i c i t a t i o n i s c o n t i n g e n t upon r e c e i p t o f a p p r o p r i a t e d funds f o r t h i s purpose. S i n c e a v a r i e t y o f approaches would r e p r e s e n t v a l i d r e s p o n s e s t o t h i s s o l i c i t a t i o n , it is a n t i c i p a t e d t h a t t h e r e w i l l b e a range o f c o s t s among i n d i v i d u a l g r a n t sawarded. W i t h respect t o post-award a d m i n i s t r a t i o n , t h e c u r r e n t p o l i c i e s and r equ i r emen t s t h a t govern t h e r e g u l a r r e s e a r c h gran t programs o f t h e N I H w i l l p r e v a i l .

REVIEW PROCEDURES AND CRITERIA

Assignment o f A p p l i c a t i o n s

A p p l i c a t i o n s w i l l be r e c e i v e d by t h e N I H , D i v i s i o n o f Research Gran t s ( D R G ) ,r e f e r r e d t o a n a p p r o p r i a t e I n i t i a l Review Group ( I R G ) f o r s c i e n t i f i c merit review, and a s s i g n e d t o i n d i v i d u a l I n s t i t u t e s f o r p o s s i b l e fund ing . Referral d e c i s i o n s w i l l b e governed by normal programmatic c o n s i d e r a t i o n s as s p e c i f i e di n t h e Referral G u i d e l i n e s o f t h e N I H , DRG. Some a p p l i c a t i o n s may r e c e i v e d u a l ass ignment .

Review Procedures

A p p l i c a t i o n s i n r e sponse t o t h i s s o l i c i t a t i o n w i l l be reviewed on a na t ionwide b a s i s i n acco rd w i t h t h e u s u a l N I H p e e r review p r o c e d u r e s . A p p l i c a t i o n s w i l l f i r s t be reviewed f o r s c i e n t i f i c and t e c h n i c a l merit by an I R G composedp r i m a r i l y of non- fede ra l s c i e n t i f i c c o n s u l t a n t s , and t h e n by t h e N a t i o n a l Advisory Counci l o f t h e a p p r o p r i a t e I n s t i t u t e ( s 1 . The review c r i t e r i a c u s t o m a r i l y employed by t h e N I H f o r r e g u l a r r e s e a r c h g r a n t a p p l i c a t i o n s w i l l p r e v a i l .

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Review Cr i te r ia

The f a c t o r s t o be c o n s i d e r e d i n t h e e v a l u a t i o n of s c i e n t i f i c merit o f each a p p l i c a t i o n w i l l b e t h o s e used i n t h e review o f t r a d i t i o n a l r e s e a r c h p r o j e c t g r a n t a p p l i c a t i o n s , i n c l u d i n g t h e n o v e l t y , o r i g i n a l i t y , and f e a s i b i l i t y o f t h e approach; t h e t r a i n i n g , expe r i ence , and r e s e a r c h competence o f t h e i n v e s t i g a t o r ( s 1 ; t h e adequacy o f t h e expe r imen ta l des ign ; t h e s u i t a b i l i t y o f t h e f a c i l i t i e s ; and t h e a p p r o p r i a t e n e s s o f t h e r e q u e s t e d budget t o t h e work proposed .

METHOD OF APPLYING

Format f o r A p p l i c a t i o n s

A p p l i c a t i o n s shou ld b e submi t t ed on form PHS 398 ( r e v . 1 0 / 8 8 ) , which is a v a i l a b l e from an a p p l i c a n t i n s t i t u t i o n ' s Office o f Sponsored Research o r from t h e N I H , DRG. U s e t h e conven t iona l format f o r r e s e a r c h p r o j e c t g r a n t a p p l i c a t i o n s and e n s u r e t h a t t h e p o i n t s i d e n t i f i e d i n t h i s ProgramAnnouncement (PA) i n t h e s e c t i o n on !'Review Procedures and C r i t e r i a " are f u l f i l l e d . To i d e n t i f y t h e a p p l i c a t i o n as a r e sponse t o t h i s PA, check "yes" on i t e m two o f page one o f t h e a p p l i c a t i o n and e n t e r t h e t i t l e "Neuroendocrinology of Human S t r e s s e l '

Deadl ine

A p p l i c a t i o n s w i l l b e accep ted i n accordance w i t h t h e announced r e c e i p t d a t e s f o r new a p p l i c a t i o n s (see r e c e i p t d a t e s and review schedu le i n a p p l i c a t i o n k i t s ) .

A p p l i c a t i o n Procedure

The o r i g i n a l and s i x c o p i e s o f t h e a p p l i c a t i o n shou ld be s e n t o r d e l i v e r e d t o :

A p p l i c a t i o n R e c e i p t D i v i s i o n of Research Grants N a t i o n a l I n s t i t u t e s o f Hea l th Westwood Bu i ld ing , Room 240 Bethesda , MD 20892xx

I n q u i r i e s

For f u r t h e r i n fo rma t ion , i n v e s t i g a t o r s are encouraged t o c o n t a c t :

Ronald N . Margol i s , Ph.D. D i r e c t o r , Endocrinology Research ProgramD i v i s i o n o f D i a b e t e s , Endocrinology, and Metabol ic Diseases NIDDWNIH Westwood Bldg . , Room 605 Bethesda, MD 20892 Telephone: ( 3 0 1 ) 496-7504

T h i s program is d e s c r i b e d i n t h e Ca ta log o f F e d e r a l Domestic A s s i s t a n c e 1 3 . 8 4 6 , A r t h r i t i s , Bone and Sk in Diseases Research and No. 1 3 . 8 4 7 , Diabe te s , Endocrinology, and Metabolism, No. 1 3 . 8 5 5 . Awards w i l l be made under t h e a u t h o r i t y o f t h e P u b l i c Hea l th S e r v i c e A c t , T i t l e 111, S e c t i o n 301 ( P u b l i c Law 78-410, as amended; 42 USC 2 4 1 ) and a d m i n i s t e r e d under PHS g r a n t p o l i c i e s and F e d e r a l R e g u l a t i o n s 42 CFR p a r t 52 and 45 CFR P a r t 7 4 . T h i s program is n o t s u b j e c t t o t h e in t e rgove rnmen ta l review requ i r emen t s o f Execut ive Order 12372 o r Hea l th Systems Agency Review.

ERRATUM

NOTICE OF SOLICITATION OF PUBLIC COMMENTS FOR THE NATIONAL PANEL FOR RESEARCH I N NEUROLOGICAL DISORDERS

P.T. 4 2 ; K.W. 0715138, 0705010, 1002030, 0710030

N a t i o n a l I n s t i t u t e of Neuro log ica l D i s o r d e r s and S t r o k e

T h i s n o t i c e , as p u b l i s h e d i n t h e N I H Guide f o r Gran t s and C o n t r a c t s on March 23 , 1990, Vol. 1 9 , No. 1 2 , c o n t a i n e d an i n c o r r e c t t e l e p h o n e number. The f o l l o w i n g is t h e c o r r e c t i n f o r m a t i o n :

u pM s . Johanna McDonoughTelephone: ( 3 0 1 ) 986-4870

*U.S.COVERNHENT P R I N T I N G OFFICE:1990-261-138:00043

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