computer interpretation of touch dna mixtures seminar for chiefs of police in western pennsylvania...
TRANSCRIPT
![Page 1: Computer interpretation of touch DNA mixtures Seminar for Chiefs of Police in Western Pennsylvania May, 2014 Allegheny County, PA Mark W Perlin, PhD, MD,](https://reader035.vdocuments.us/reader035/viewer/2022070418/56649f315503460f94c4d1ff/html5/thumbnails/1.jpg)
Computer interpretation oftouch DNA mixtures
Seminar for Chiefs of PoliceSeminar for Chiefs of Policein Western Pennsylvaniain Western Pennsylvania
May, 2014May, 2014Allegheny County, PAAllegheny County, PA
Mark W Perlin, PhD, MD, PhD Mark W Perlin, PhD, MD, PhD Cybergenetics, Pittsburgh, PACybergenetics, Pittsburgh, PA
Cybergenetics © 2003-2014Cybergenetics © 2003-2014
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DNA biology
Locus
Chromosome
Nucleus
Cell
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Short tandem repeat
Take me out to the ball gametake me out with the crowdbuy me some peanuts and Cracker JackI don't care if I never get backlet me root root root root root root root root root root for the home team,if they don't win, it's a shamefor it's one, two, three strikes, you're outat the old ball game
"root" repeated 10 times, soallele length is 10 repeats
23 volumes in cell'sDNA encyclopedia
DNA locus paragraph
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DNA genotype
10, 121 2 3 4 5 6 7 8
ACGT
1 2 3 4 5
A genetic locus has two DNA sentences,one from each parent.
locus
Many alleles allow formany many allele pairs. A person's genotype is relatively unique.
motherallele
fatherallele
repeated word
An allele is the numberof repeated words.
A genotype at a locusis a pair of alleles.
9 10
6 7 8 9 101112
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One person, one genotype
7
14
locus
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DNA dataOne or two allele peaks at a locus
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DNA identification pathwayEvidence genotype
Known genotype
7 14
7, 14
7, 14
Lab Infer
Compare
Evidence item
Evidencedata
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Match information
Prob(evidence matches suspect)
Prob(coincidental match)before
data
(population)
after(evidence)
20
=100%
5%
=
At the suspect's genotype,identification vs. coincidence?
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Two people, two genotypes
7
14
10
12
locus
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DNA mixture dataQuantitative peak heights at a locus
peak size
peakheight
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DNA pathway brokenEvidence genotype
Known genotype
???
10, 12
Lab Infer
Compare
Evidence item
Evidencedata
+
7 10 12 14
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Human interpretation issues
• call good data inconclusive• peaks are too low for them• too many contributors to handle• potential examination bias
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TrueAllele® Casework
• preserve data information• use all peaks, high or low• any number of contributors• entirely objective, no bias
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DNA pathway restoredLab InferEvidence
itemEvidence
data
7 10 12 14
+
Known genotype
10, 10 @ 30%10, 12 @ 50%10, 14 @ 20%
10, 12
Compare
Evidence genotype
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Match information preserved
Prob(evidence matches suspect)
Prob(coincidental match)before
data
(population)
after(evidence)
10
= 50%
5%
=
At the suspect's genotype,identification vs. coincidence?
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Leicestershire bank robbery
England
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Black balaclava
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Brown parka
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Black shoes
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Helicopter view
Bank
House
Lutterworth
Broughton Astley
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Brown parka
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Black balaclava
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Black shoes
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Informative peak height patternQuantitative peak heights from parka at locus TH01
peakheight
peak size
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How people use less of the data
Threshold
Over threshold, peaks are labeled as allele events
All-or-none allele peaks,each given equal status
Under threshold, alleles vanish
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DNA lab report: Balaclava
A sample from the inside crown area of the balaclava (item JAS/3) was submitted for DNA profiling tests.
A complex mixed DNA results which appeared to have originated from at least four people was obtained from biological material on the crown.
In my opinion, this result is not suitable for meaningful comparison.
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DNA lab report: Shoes
The inside heel area and the toe area of the left shoe (item PAC/2) were submitted separately for DNA profiling tests.
Mixed DNA results which appeared to have originated from at least three people were obtained from biological material on each of the sampled areas. In my opinion, Leroy Williams could have contributed DNA to these results in that all of the components that make up his DNA profile are represented in the result;
however, due to the overall complexity of the results and the number of contributors to them, a statistical evaluation is not possible.
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DNA lab report: Parka
The left and right cuff areas of the brown parka (item CEG/2) were submitted separately for DNA profiling tests. A complex mixed DNA results which appeared to have originated from at least four people was obtained from biological material on the right cuff. In my opinion, this result is not suitable for meaningful comparison.
A mixed DNA result, which appeared to have originated from at least three people was obtained from biological material recovered from the left cuff of the brown parka (CEG/2). In my opinion Leroy Williams could have contributed DNA to this result; however, the finding is not suitable for statistical evaluation.
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TrueAllele® Technology
ViewStationUser Client
DatabaseServer
Interpret/MatchExpansion
Visual User InterfaceVUIer™ Software
Parallel Processing Computers
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Informative peak height patternQuantitative peak heights from parka at locus TH01
peakheight
peak size
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How the computer thinksConsider every possible genotype solution
Explain thepeak pattern
Better explanationhas a higher likelihood
Allele pair from one person
Another person's Another person's allele pairallele pair
A third person's A third person's allele pairallele pair
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Objective genotype determined solely from the DNA data.
Never sees a comparison reference.
Evidence genotype
99.98%
0.01%0.01%
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DNA match information
Prob(evidence match)
Prob(coincidental match)
How much more does the suspect match the evidencethan a random person?
10x99.98%
11%
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Match information at 10 loci
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Is the suspect in the evidence?
A match between the parka and Leroy Williams is: 10.2 quadrillion times more probable than a coincidental match to an unrelated Black person
A match between the shoe and Leroy Williams is: 13.9 quadrillion times more probable than a coincidental match to an unrelated Black person
A match between the balaclava and Leroy Williams is: 15.7 quadrillion times more probable than a coincidental match to an unrelated Black person
10,000,000,000,000,000
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The TrueAllele option
Objective, reliable truth-seeking tool
• solves the DNA mixture problem• relatives & up to six contributors• handles low-copy and degraded DNA• provides accurate DNA match statistics• easy to understand, easy to explain• automates DNA evidence interpretation
When a report says "a meaningful comparison" or "a statistical evaluation” is not possible,
TrueAllele is often highly effective.
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Reliable: validation studiesPerlin MW, Sinelnikov A. An information gap in DNA evidence interpretation. PLoS ONE. 2009;4(12):e8327.
Perlin MW, Legler MM, Spencer CE, Smith JL, Allan WP, Belrose JL, Duceman BW. Validating TrueAllele® DNA mixture interpretation. Journal of Forensic Sciences. 2011;56(6):1430-47.
Ballantyne J, Hanson EK, Perlin MW. DNA mixture genotyping by probabilistic computer interpretation of binomially-sampled laser captured cell populations: Combining quantitative data for greater identification information. Science & Justice. 2013;53(2):103-14.
Perlin MW, Belrose JL, Duceman BW. New York State TrueAllele® Casework validation study. Journal of Forensic Sciences. 2013;58(6):1458-66.
Perlin MW, Dormer K, Hornyak J, Schiermeier-Wood L, Greenspoon S. TrueAllele® Casework on Virginia DNA mixture evidence: computer and manual interpretation in 72 reported criminal cases. PLOS ONE. 2014:9(3)e92837.
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TrueAllele in criminal trials
Court testimony:• state• federal• military• international
About 200 case reports filed on DNA evidence
Crimes:• armed robbery• child abduction• child molestation• murder• rape• terrorism• weapons
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Blairsville, PA DentistDr. John Yelenic
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State Trooper Arrested
November 2007: Kevin Foley charged with crime
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Fingernail DNA Evidence
93.3% victim + 6.7% DNA component
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Three DNA Match Statistics
Score Method13 thousand inclusion
23 million with victim189 billion TrueAllele
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The Verdict
"John Yelenic provided the most eloquent and poignant evidence in this case," said the prosecutor, senior deputy attorney general Anthony Krastek. "He managed to reach out and scratch his assailant," capturing the murderer's DNA under his fingernails.
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• • •
Pennsylvania Precedent
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Pennsylvania Cases
AlleghenyBeaverBerksButlerCambriaColumbiaDelawareIndianaLuzerneMercerYork
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Allegheny County
Crime Evidence Defendant Outcome Sentence
rape clothing Ralph Skundrich guilty 75 years
murder gun, hat Leland Davis guilty 23 years
rape clothing Akaninyene Akan guilty 32 years
murder shotgun shells James Yeckel, Jr. guilty plea 25 years
murder fingernail Anthony Morgan stipulation life
weapons gun Thomas Doswell guilty plea 1 year
drugs gun Derek McKissick& Steve Morgan
2 guilty pleas 2 1/2 years
murder door handle, shirt sleeves
Calvin Kane guilty plea 20 years
19 cases, 15 reports3 trials, 1 exoneration
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TrueAllele today
Invented math & algorithms 20 years
Developed computer systems 15 years
Support users and workflow 10 laboratories
Used routinely in casework 3 labs
Validate system reliability 20 studies
Educate the community 50 talks
Train & certify analysts 200 students
Go to court for admissibility 5 hearings
Testify about LR results 20 trials
Educate lawyers and laymen 1,000 people
Make the ideas understandable 200 reports
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All the DNA, all the time
TrueAllele applications:
• eliminate DNA backlogs• reduce forensic costs• solve crimes• find criminals• convict the guilty• free the innocent• create a safer society
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http://www.cybgen.com/information
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