complications of pregnancy
DESCRIPTION
Complications of Pregnancy. Author: Evelyn M. Hickson, RN, MSN, CNS, WCC. Objectives. Describe and define the following complications of pregnancy; discuss predisposing factors, and management of: Preterm Labor Premature Rupture of Membranes Diabetes Thrombophelias Pulmonary Edema - PowerPoint PPT PresentationTRANSCRIPT
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Complications of Pregnancy
Author: Evelyn M. Hickson, RN, MSN, CNS, WCC
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ObjectivesDescribe and define the following complications ofpregnancy; discuss predisposing factors, andmanagement of: Preterm Labor Premature Rupture of Membranes Diabetes Thrombophelias Pulmonary Edema Bleeding Complications of Pregnancy (Placenta
previa, Abruption, DIC)
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Preterm Labor
Definition: Persistent uterine contractions that are accompanied by dilatation and/or effacement as detected by digital exam (Gonik and Creasy 1986)
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Preterm Labor One of the most common
complications during pregnancy Issue is the appropriate diagnosis
and monitoring Treatment modalities still have not
been proven to work
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Definitions: Preterm Delivery Any birth, regardless of birth weight,
that occurs before 37 completed weeks from the first day of the last menstrual period
Beginning at 20 weeks and ending at 36 6/7 weeks (Creasy and Resnik, 2004)
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Risk Factors Contributing to Preterm Delivery
Hypertension Systemic infections Pyelonephritis Drug abuse Maternal race Previous preterm birth Low prepregnancy weight Absent or inadequate PNC <18yrs >35yrs Strenuous work High personal stress Anemia Smoking Bacteriuria Genital colonization or infection Cervical injury or abnormality Uterine anomaly Low socioeconomic status
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Risk Factors Contributing to Preterm Delivery
Preterm labor Ruptured membranes Multiple gestation Preeclampsia Abrupto placenta Placenta previa Vaginal bleeding Growth restriction Oligo, polyhydramnios Fetal anomalies Uterine anomalies Chorioamnionitis Incompetent cervix Diabetes Connective tissue disorders Poor nutrition Peridonal disease Fibroids
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Spontaneous Preterm Labor Risk factors
preterm rupture of membranes incompetent cervix amnionitis genital tract infection nonwhite race multiple gestation second trimester bleeding low prepregnancy weight previous preterm birth
About 75% of preterm births fall into the spontaneous category (Creasy and Resnik)
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Epidemiology Poorly understood Recent Studies have theorized: Response to chronic intrauterine
inflammatory insult Influenced by fetal and maternal immune
response Infection induced activation for the fetal
hypothalamic-pituitary-adrenal axis, the fetal membranes and decidua produce cytokines which initiate labor or rupture of membranes.
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Signs and Symptoms-Nonspecific and not necessarily those of
labor at term -Pelvic pressure -Increased vaginal discharge -Backache -Menstrual-like cramps -Painful or painless contractions, different
from Braxton-Hicks only in their persistence
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Difficulty with Accurate Diagnosis Fetal fibronectin test – can improve
accuracy of diagnosis—negative Predictive value with dilatation
<3cm and effacement <80% for delivery
Within 7-14 days good, positive predictive value not good
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Difficulty with Accurate Diagnosis High prevalence of S&S among healthy
women not in preterm labor Imprecision of digital exam Contraction frequency (4 or more per hour
) has low sensitivity and low positive predictive value
Endovaginal ultrasonography cervical length of 30mm or greater has very high negative predictive value in symptomatic women
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Diagnosis
Cervical effacement of 80% or greater
Dilation of more than 2 cm Change in dilation of 1 cm or more Sonographic cervical length under
30mm or a positive fetal fibronectin
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Management Variety of drugs available-no clear first
line drug-clinical situation and physician preference
Antibiotics do not appear to prolong gestation, should be used for GBS prophylaxis if delivery is imminent
Maintenance or repeated acute tocolysis doesn’t improve perinatal outcome used generally
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Managment Tocolytic drugs may prolong pregnancy 2-
7 days which may allow for steroids to improve lung maturity, and transport to a tertiary center
Antenatal corticosteroids significantly reduce the incidence and severity of neonatal RDS. Also reduce incidence of IVH and necrotizing enterocolitis.
Decrease neonatal mortality.
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Tocolytic Agent
Dosage and Administration
Contraindica-tions
Maternal Side Effects
Fetal and Neonatal Side Effects
Betamimetic Terbutaline .25mg sub Q every 20 min to 3 hrs hold for pulse >120
Cardiac arrhythmias
Cardiac arrhythmiaPulmonary edema
Fetal tachycardia HyperinsulinemiaHyperglycemiaMyocardial and septal hypertrophyMyocardial ischemia
Magnesium Sulfate
4-6 g bolus for 20 min, then 2-3 g/hr
Myasthenia gravis Flushing,lethargy,Headache,muscle weakness, diplopia, dry mouth, pulmonary edema, cardiac arrest
Lethargy, hypotonia, respiratory depression prolonged use demineral-ization with
Tocolytics
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Calcium channel blockers
Nifedipine 30mg loading dose, then 10-20mg q 4-6 hr
Cardiac disease, use caution with renal disease, hypotension ,90/50 mm HG avoid concomitant use with magnesium sulfate
Flushing, headache, diaainess, nausea, transient hypotension
None noted
Prostaglandin gynthetase inhibitors
Indomethacin loading dose of 50 mg rectally or 50-100mg orally, then 25-50mg orally every 6hrx48hrs
Sig. Renal or hepatic impairment
Nausea, heartburn Constriction of ductus arteiosus, pulmanary hypertension, reversible decrease in renal function with oligo, IVH, hyperbilirubinemia, necrotizing enterocolitis
Tocolytics
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Nursing Care: Evaluation for Preterm Labor
History (risk factors) S&S of preterm labor S&S UTI S&S vaginitis/cervicitis/STDs S&S viral or bacterial infection S&S PROM
Physical Exam VS Evaluate gestational age Electronic monitor and palpate contractions Electronic monitor of FHR and pattern Abdominal palpation for presentation, position,
multiple gestation, EFW, pain Costovertebral angle tenderness Low back or suprapubic pain
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Evaluation for Preterm Labor
Pelvic Exam Speculum exam for vaginitis,cervicitis,STDs,PROM,
bloody show, meconium Digital exam for cervical changes (not done if PROM
found on spec exam)
Lab tests UA, urine culture and sensitivity Wet mount for Bacterial Vaginosis or Trichomonas GBS cultures and cultures of any lesions GC and chlamydia cultures CBC with differential Nitrazine and ferning if appropriate
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Nursing Care of Woman in Preterm Labor Bedrest, lateral position IV, hydration has not been shown to be
effective in stopping labor and increases risk of pulmonary edema
Continuous uterine and fetal monitoring Medications as ordered Arrange for transport if planned Arrange for care of infant, staffing,
pediatrician, respiratory therapy, equipment
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Premature Rupture of Membranes (PROM) Definition: Rupture of membranes
before the onset of labor Preterm premature rupture of
membranes (PPROM)is rupture of membranes before the onset of labor at <37 weeks gestation
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Term PROM Complicates 8% of pregnancies Generally followed by onset of labor and
delivery In a large randomized study, with
expectant management, and ½ of women with PROM delivered within 5 hours, and 95% delivered within 28 hours.
Risks—intrauterine infection—increases with duration of membrane rupture, umbilical cord compression (ACOG practice bulletin)
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Etiology of Membrane Rupture at Term
Combination of stretching with uterine growth, strain from uterine contractions and fetal movement
Biochemical changes, including a decrease in collagen content
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Management PROM
May induce labor immediately Observe for the onset of
spontaneous labor for up to 24-72 hours (if observing need to avoid digital exams which increase the risk of infection)
Antibiotics if GBS positive or if rupture >18 hours
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Risk Factors Smoking Multiple gestation Abruptio placenta Cocaine use Previous PPROM Previous cervical operations or lacerations Occupational fatigue, long working hours Vitamin C and E deficiencies
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Management Antibiotics—prolongs latency period and
improve perinatal outcome with expectant management prior to 35 weeks
Administration of corticosteroids if <32 weeks (some recommend <34 weeks*)
Avoid digital exams if not in labor and immediate induction is not planned
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Nursing Care
Accurate history: time, amt, color, odor, intercourse
Physical Exam: VS,FHR, contractions, abdominal palpation
Sterile Speculum Exam: vulva, vaginal pooling, fluid from os, cord, fetal part, nitrazine, fFN, amnitoic protein, cervical cultures, GBS
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Nursing Care continued In labor assess temp q2 hrs,
otherwise q 4 hrs Monitor FHR, cord compression or
tachycardia Avoid unnecessary vaginal exams Watch hydration, dehydration can
cause a temp elevation
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Diabetes Mellitus Definition: Gestational Diabetes is the
presence of carbohydrate intolerance of varying degrees of severity with an onset or first recognition during pregnancy. (Varney)
Incidence: Averages about 7%, varies with ethnicity
Increased in Hispanic, African, Native American, South or Eastern Asian, or Pacific Islander
Pregestational Diabetes: Diabetes which antedates the pregnancy
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Pre-Gestational Diabetes
Type I or Type II Type I: True insulin-dependent, typically
develops prior to adolescence, usually diagnosed prior to pregnancy.White classification of B,C,D,F and above
Type II: Not necessarily insulin dependent and usually begins after age 40
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Risk Factors
1. Marked obesity2. Hx GDM prior pregnancy3. Strong family Hx4. Previous infant >4000 gm5. Hx unexplained stillbirth6. Poor OB Hx, SABs, congenital anomalies7. Recurrent glycosuria (2 positive tests)
unexplained by diet
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Physiology Gestational Diabetes Similar to type II Diabetes: Insulin is
available Hormonal changes alter receptivity to
insulin <20 weeks cells more responsive to insulin >20 weeks, as placenta grows, production
of human placental lactogen (HPL) increases
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Physiology of Gestational Diabetes HPL increases cellular resistance to
insulin When production of insulin cannot
keep up with rising need hyperglycemia results
Peak effect of HPL 26 to 28 weeks
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Risks of Diabetes Pregestational Diabetes: Congenital
anomalies,spontaneous AB, stillbirth, IUGR, HTN, preeclampsia
Gestational Diabetes: If early pregnancy blood sugars not elevated, no increase in anomalies, but increase in macrosomic infants, protracted labor, shoulder dystocia, operative delivery HTN and preeclampsia, Type II Diabetes later in life
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Macrosomic Infant
Insulin similar to Human Growth Hormone Glucose crosses the placenta Fetus increases insulin production to
metabolize glucose Hyperplasia and hypertrophy of cells
causing lifelong change increasing risk of obesity as well as diabetes
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Screening tests ADA recommends random
nonfasting 1hour post 50 gram glucola <130-140
(early with risk factors, 24-28 weeks for everyone)
3 hour glucose tolerance test
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Management ADA diet—same nutrition requirements as
nondiabetic women —2000 to 2200k cal diet, may consider caloric restriction in obese women no more than 33%
Balance of calories from carbohydrate, fat and protein
Home glucose monitoring Fasting <95mg/dl, 1 hr <140, 2hr <120
Careful evaluation of fetal size and fluid volume, ultrasound if necessary but poor predictor of EFW
Optimal antenatal testing for diet controlled GDM with no other risk factors not established
Usually recommend DFMC from 34 to 36 wks on at 40 weeks NST or BPP
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Management Mild to moderate exercise If well controlled with diet alone, await
spontaneous labor Insulin or glyburide if poorly controlled with diet Consider C-Section if EFW >4500 gm 6 week postpartum glucose testing Labor management the same as nondiabetic
with higher level of suspicion for shoulder dystocia
IV fluids should not contain glucose
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Nursing Care Same as any woman in labor Notify pediatrician of diabetic mom Anticipate shoulder dystocia and be prepared to
help Avoid glucose containing IV fluids unless on
insulin drip and NPO If on insulin, periodic blood glucose checks and
insulin as ordered Anticipate postpartum uterine atony/hemorrhage
if macrosomic infant Watch vital signs closely and be aware of
increased risk for HTN
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Thrombophilia
Definition: Tendency toward blood clot formation Most common inherited are:
1. Factor V Leiden2. Prothrombin G20210A mutation
Less common inherited are:1. Deficiency of anticoagulants protein C,
proteinS, and antithrombin III
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Thrombophilia
Most common acquired:1. Antiphospholipid antibody syndrome2. Lupus Anticoagulant3. Anticardiolipin antibodies
Less common acquired: 1. Lupus Anticoagulant2. Anticardiolipin Antibodies
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Risk Factors for Deep Vein Thrombosis and Thromboembolic Disorders
Hereditary thrombophilia Acquired thrombophilia Mechanical heart valve Atrial fibrillation Trauma/prolonged immobilization/major
surgery History of deep vein thrombosis Strong family history of thrombosis or
thromboembolic events Pregnancy Oral contraceptive use
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Testing for Thrombophilias
History of thrombosis First degree relative with thrombophilia Recurrent fetal loss History of early or severe preeclampsia Severe unexplained IUGR
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Signs and Symptoms - Superficial Thrombophlebitis
Leg pain Localized heat, tenderness or
inflammation at site Palpation of knot or cord
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Signs and Symptoms DVT Slight temperature elevation Mild tachycardia Abrupt onset with severe leg pain worse
with motion or standing Edema of ankle,leg,thigh Positive Homan’s sign Pain with calf pressure Tenderness along entire course of involved
vessel with palpable cord
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Signs and Symptoms of Pulmonary Embolism
Dyspnea Tachycardia Tachypnea Breath sounds few rales or wheezes Low PO2 and O2 saturation Hemoptysis Pleuritic chest pain
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Pleural friction rub or signs of effusion
Hypoxia Hypotension Cyanosis Jugular venous distention Right ventricular heave (lower left
sternal border)
Signs and Symptoms of Pulmonary Embolism
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Management of Thrombophilias
Appropriate testing for thrombophilias High index of suspicion with risk factors Occasional prophylactic anticoagulation
with sub q heparin injection During labor, if anticoagulant therapy is
required, IV heparin is used Postpartum, switch back to sub q heparin
overlapping with coumadin With some anticoagulants neuraxial
blocks should not be used for 24 hours after last injection
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Nursing Care
Recognize increased risk for thromboembolic events and be prepared
If on anticoagulants, recognize increased risk for bleeding and be prepared
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Pulmonary Edema Usually due to excess capillary pressure
as in cardiomyopathy, mitral stenosis or due to a disruption of alveolar capillary membrane integrity as in pneumonia, ARDS (Gabbe, Niebyl, Simpson, 2002)
Two general causes alveolar flooding: caused by heart failure or permeability edema from alveolar-capillary injury. In many OB cases both are present (Williams OB, 2001)
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Risk Factors for the Development of Pulmonary Edema
Maternal cardiac disease (structural, ischemic or dysrhythmia)
Eclampsia, severe preeclampsia, or other significant hypertensive disease
Antepartum hemorrhage HELLP syndrome Use of tocolytics, Betamimetics, Magnesium Sulfate Fluid overload Infection - occult chorioamnionitis and sepsis Adult Respiratory Distress Syndrome
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Risk Factors/Acute Lung Injury Pneumonia:
Aspiration, bacterial, viral
Sepsis: Chorioamnionitis, pyelonephritis, puerperal infection, septic abortion
Hemorrhage: Shock, massive transfusion therapy
Arsenic poisoning Preeclampsia (Williams OB, 2001)
Embolism: Amnionic fluid, trophoblastic disease, air
Connective-tissue disease Substance abuse: Heroin, methadone Irritant inhalation and burns Pancreatitis Pheochromocytoma
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Signs and Symptoms Dyspnea Cough Orthopnea Tachycardia Hemoptosis (occasionally)
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Management O2 supplementation Diuretics Discontinuation of offending agent Ventilatory support Circulatory support Treatment of underlying cause
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Nursing Care Unless very mild, requires Intensive
Care with invasive hemodynamic monitoring
Labor and Delivery nurses role primarily in close monitoring of patient at risk, early recognition of signs of decompensation, prevention of iatrogenic causes
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Hypertensive Disorders of Pregnancy Chronic Hypertension Gestational Hypertension Preeclampsia Eclampsia HELLP syndrome
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Effects of HTN on Pregnancy Worsening or malignant HTN CNS involvement – stroke,
hemorrhage Cardiac decompensation Renal deterioration or failure Decreased uteroplacental perfusion
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Hypertension in PregnancyChronic HTN: Present before the 20th week of pregnancy or present
before pregnancy Systolic greater than or equal to 140 and/or diastolic
greater than or equal to 90 Mild=140/90 Severe=180/110
Use of antihypertensive meds before pregnancy Persistence of HTN beyond postpartum period
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Hypertension in PregnancyGestational Hypertension Replaces older term PIH
(pregnancy induced hypertension) Describes cases in which elevated
blood pressure without proteinuria develops after 20 weeks and returns to normal after delivery (ACOG Practice Bulletin 33)
25% of these women develop preeclampsia
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Complications of Gestational Hypertension and Pre-eclampsia
At higher risk for pulmonary edema due to dramatic decrease in colloid osmotic pressure
Highest risk is 6-24 hours post-delivery prior to diuresis
S & S of pulmonary edema: Decreased SaO2 Wheezing/SOB Neck vein distention Tachypnea Tachycardia Lungs dull to
percussion Cough (Productive or
Nonproductive) Anxiety
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Nursing Care Monitor: Signs and symptoms of decline in patient
condition Maternal and Fetal Well-being (done by
OB) Strict I & O Respiratory Status - Pulmonary Edema Renal and Hepatic Function Clotting Capability – potential for bleeding Psych-Social Support of patient and family
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Hypertension in PregnancyPreeclampsia Definition: Pregnancy specific syndrome that
usually occurs after 20 weeks (except in trophoblastic disease)
Characterized by: BP elevation of 140 or greater systolic or 90 or greater diastolic in previously normotensive woman, accompanied by proteinuria of .3g or more in 24 hours, or 1+ or greater reading on dipstick
Suspect preeclampsia if elevated BP without proteinuria but with HA, blurred vision, abdominal pain, low platelets, abnormal liver enzymes
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Risk Factors for Preeclampsia Nulliparity Trophoblastic disease Multiple pregnancy CHTN Preexisting renal disease Pregestational diabetes Family history of preeclampsia or eclampsia Hx of preeclampsia in previous pregnancy Multipara with new sexual partner African or Asian ethnicity Thrombophilia
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Signs and Symptoms Persistent HA Dizziness, blurred vision, scotomata Persistent epigastric pain BP elevation Ophthalmic Exam: Papilledema, A-V
nicking, vessel; narrowing, hemorrhagic areas
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Lab Value Changes Platelets - Low
> 100 K is severe disease Serum Uric Acid – High BUN – Normal to High Serum Creatinine – Normal to High Liver Function – Elevated Urine Protein – Increased
3-4+ with 5 Grams/L in 24 hrs = severe disease 2-3+ with 1 Grams/L in 24 hrs diagnostic of
preeclampsia
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Treatment Magnesium Sulfate 4-6 Gram IV load over
20 minutes followed by 2 Grams /hr and maintained for 12-24 hours post partum
Antihypertensive Medications for diastolic >105-110
If still pregnant with viable baby – determine severity of disease, risk to mother and to baby and determine if mom needs to be delivered
If baby has demised, deliver
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Eclampsia Preeclampsia disease process that
progresses to convulsions Most common prior to delivery but
may occur to 10+ days post partum
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Seizure Aura “Worst Headache Ever” Feeling Weird Ringing in ears Visual Disturbance Epigastric / Right Upper Quadrant
Pain
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Seizure Characteristics Fixation of diaphragm during seizure Respirations may cease during seizure Duration vary Cyanosis Fetal Bradycardia (if still pregnant) Potential for: Sudden Death Massive Cerebral Hemorrhage Blindness due to retinal detachment, occipital
lobe ischemia, infarction or edema Cerebral Edema
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Treatment If still pregnant and baby alive and
viable: Reload with Magnesium Sulfate 4-6
Grams Magnesium Sulfate drip rate at 2
Grams/hour No use of Valium – use Ativan Deliver
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HELLP Syndrome
Combination of hemolysis(H), elevated liver enzymes(EL), and low platelets (LP)
Liver involvement in preeclampsia-eclampsia
May occur in as many as 20% of women with severe preeclampsia
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HELLP Syndrome Increased risk of averse outcomes Increased risk of abruptio placenta Renal failure Subcapsular hepatic hematoma Recurrent preeclampsia Preterm delivery Fetal and maternal death
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Signs and Symptoms Upper abdominal pain, epigastric or right
upper quadrant Thrombocytopenia Elevated liver enzymes aspartate
aminotransferase typically less than 200 to 500U/L
Sometimes serum bilirubin is elevated, seldom greater than 2-4 mg/dL
Intrahepatic and subcapsular hemorrhage Liver rupture, fatal hemorrhage
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Signs and Symptoms Most cases obvious preeclampsia Patients either present with or report
having symptoms of “flu” Most have no symptoms relating to liver,
but if there is pain liver more likely involved
Hepatic failure with encephalopathy and consumptive coagulopathy are not usual
Patient may become comatose if HELLP severe enough
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Management
Prompt delivery Lab abnormalities peak by 23-48
hours and begin to normalize in 2-3 days
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References Burrow, G.N., MD; Duffy, T.D., MD (Eds.) (1999). Medical Complications
During Pregnancy fifth edition. Pennsylvania: W.B. Saunders Company. Creasy, R.K., MD; Resnik, R., MD (Eds.) (2004) Maternal-fetal Medicine,
Principles and Practice fifth edition. Pennsylvania: Saunders Cunningham, F.G., Gant, N.F., Leveno, K.J., Gilstrap III, L.C., Hauth, J.C.,
Wenstrom, K.D. (Eds.) (2001) Williams Obstetrics twenty first edition. New York: McGraw-Hill.
Gabbe, S.G., Niebyl, J.R., Simpson J.L. (Eds.) (2002). Obstetrics, Normal and Problem Pregnancies fourth edition. Pennsylvania: Churchhill Livingstone.
Netter, F.H., MD (Ed.) (1965) The CIBA Collection of Medical Illustrations Vol. 2 Reproductive System. New York: CIBA Pharmaceutical Company.
Varney, H.; Kriebs, J.M.; Gegor, C.L., (2004) Varney’s Midwifery fourth edition. Canada: Jones and Bartlett Publishers.
The American College of OB/GYN (Ed.) (2004) 2004 Compendium of Selected Publications. Washington D.C.: The American College of OB/GYN.