COMPASS

ChicagO Multiethnic Prevention And Surveillance Study

Habibul Ahsan

Karen Kim, Doriane Miller, Diane Lauderdale, Michelle Le Beau, Dezheng Huo, Brian Chiu, Andrea King, Funmi Olopade, Sola Olopade, Stacy Lindau, Lainie Ross, Nancy Cox, Marshall Chin, Kathleen Cagney, Lianne Kurina, Ronald Thisted, Mark Lingen, Geoffrey Greene, Muhammad Kibriya, Maria Argos, Briseis Aschebrook-Kilfoy

What is COMPASS?

• Its a health study designed by researchers at the University of Chicago to understand how lifestyle, environment, genetic, and healthcare-related factors affect health of Chicagoans.

• By identifying the determinants of these diseases, we aim to help develop new strategies to prevent cancer and other chronic diseases among Chicago residents.

Rationale

Chronic diseases like cancer, heart disease, stroke, diabetes and respiratory disease are the biggest causes of disability and mortality, days lost at work, lower quality of life and high health care costs.

There is disparity in the distribution of these illnesses, their known causes and care-related factors across population.

Temporal Trends and Black:White Disparity in Cancer Rates in Cook County & US [Women]

Black Females Black Females1990-1994 2005-2009 1990-1994 2005-2009 1990-1994 2005-2009 1990-1994 2005-2009

rate rate % change rate rate % change B:W IRR rate rate % change rate rate % change B:W IRR

Oral and pharynx 6.0 6.2 3.0 8.2 6.3 -23.0 1.02 7.2 6.4 -11.0 7.2 5.7 -21.0 0.89

Esophagus 2.2 2.0 -9.1 5.9 2.9 -50.1 1.45 2.0 1.9 -5.0 5.1 2.8 -45.1 1.47

Stomach 6.5 6.0 -7.7 9.7 8.7 -10.3 1.45 5.1 4.0 -21.6 9.4 8.6 -8.5 2.15

CRC 49.2 41.8 -15.0 54.4 54.6 3.7 1.31 48.8 39.1 -19.9 58.0 50.3 -13.3 1.29

Liver 1.7 2.9 70.6 2.5 4.0 60.0 1.38 1.5 2.5 66.7 2.7 4.6 70.4 1.84

Pancreas 9.1 11.8 29.7 12.4 16.4 32.2 1.39 9.7 10.6 9.3 14.9 15.4 3.4 1.45

Lung & Bronchus 48.3 56.1 16.1 54.9 66.4 20.9 1.18 50.6 54.3 7.3 54.8 57.3 4.6 1.06

Bladder 10.7 10.6 -0.9 7.9 8.5 7.6 0.8 10.2 9.7 -4.9 7.8 7.3 -6.4 0.75

Kidney 7.4 11.4 54.1 6.5 12.8 96.9 1.12 7.7 10.5 36.4 8.0 12.3 53.8 1.17

Brain 5.6 5.4 -3.6 3.6 3.9 8.3 0.72 6.2 6.0 -3.2 3.6 3.9 8.3 0.65

Breast 134.6 124.1 -7.8 113.1 124.4 9.9 1 135.9 130.6 -3.9 120.4 123.5 2.6 0.95

Cervical 11.4 8.5 -25.4 23.0 15.1 -34.3 1.78 9.3 6.5 -30.1 15.0 8.6 -42.7 1.32

Uterine 26.6 29.2 9.8 15.7 24.1 53.5 0.83 25.8 25.8 0.0 16.2 21.6 33.3 0.84

Ovary 17.1 14.5 -15.2 10.9 10.0 -8.3 0.69 15.9 13.4 -15.7 11.3 10.0 -11.5 0.75

Hodgkins 2.8 2.8 0.0 1.9 2.4 26.3 0.86 2.8 2.9 3.6 2.3 2.5 8.7 0.86

NHL 15.3 16.6 8.5 8.5 10.8 27.1 0.64 15.8 17.7 12.0 9.8 13.2 34.7 0.75

MM 3.7 4.2 13.5 8.8 9.5 8.0 2.26 4.3 4.3 0.0 10.8 11.1 2.8 2.58

Leukemia 9.6 10.0 4.0 6.4 7.5 17.0 0.75 10.4 10.6 2.0 8.8 8.1 -8.0 0.76

Rate is per 100,000 woman-years

Cook County USA (SEER) White Females White Females

Temporal Trends and Black:White Disparity in Cancer Rates in Cook County & US [Men]

Black Males Black Males1990-1994 2005-2009 1990-1994 2005-2009 1990-1994 2005-2009 1990-1994 2005-2009

rate rate % change rate rate % change B:W IRR rate rate % change rate rate % change B:W IRR

Oral and pharynx 15.1 15.9 5.0 25.7 19.5 -24.0 1.23 18.0 16.2 -10.0 25.6 15.6 -39.0 0.96

Esophagus 7.8 8.8 12.8 19.4 10.2 -47.4 2.49 7.1 8.4 18.3 17.8 8.0 -55.1 0.95

Stomach 14.1 11.6 -17.7 22.5 20.0 -11.1 1.72 11.9 9.1 -23.5 23.2 17.3 -8.5 2.15

CRC 74.1 57.3 -22.7 72.3 80.0 10.7 1.40 70.5 50.9 -27.8 76.6 63.6 -17.0 1.25

Liver 5.0 10.2 104.0 7.5 14.8 97.3 1.45 4.4 8.5 93.2 8.9 16.8 88.7 1.98

Pancreas 11.7 15.2 29.9 16.4 19.9 21.3 1.31 12.5 14.0 12.0 19.5 18.5 -5.1 1.32

Lung & Bronchus 93.4 76.7 -17.9 132.7 112.3 -15.3 1.46 93.9 71.5 -23.9 139.3 99.0 -28.9 1.38

Bladder 41.2 39.9 -3.2 15.8 21.1 33.5 0.53 40.7 41.1 0.9 20.7 21.0 -6.4 0.51

Kidney 15.6 20.8 33.3 14.6 25.8 76.7 1.24 15.3 20.2 32.0 17.2 26.0 51.1 1.29

Brain 8.7 7.6 -12.6 4.8 4.5 -6.3 0.59 9.0 8.6 -4.4 4.4 4.4 0.0 0.51

Prostate 154.9 145.1 -6.3 216.9 248.7 14.6 1.71 200.8 155.4 -22.6 300.4 249.4 -17.0 1.60

Testis 4.9 6.0 22.4 1.2 1.3 8.3 0.22 6.0 6.9 15.0 0.8 1.4 75.0 0.20

Hodgkins 3.3 3.3 0.0 3.2 3.4 6.3 1.03 3.6 3.6 0.0 2.9 3.5 8.7 0.97

NHL 22.5 24.9 10.7 13.1 15.6 19.1 0.63 24.5 26.0 6.1 19.3 18.9 -2.1 0.73

MM 5.6 6.6 17.9 11.3 13.1 15.9 1.98 6.8 7.1 4.4 14.9 15.0 0.7 2.11

Leukemia 15.2 16.4 8.0 11.7 13.8 18.0 0.84 18.1 17.7 -2.0 13.8 13.7 -1.0 0.77

Rate is per 100,000 man-years

Cook County USA (SEER) White Males White Males

Excess Cancer in Women in Cook CountyWhite Females Black Females

COOK/SEER COOK/SanFranCook/Detroit Cook/Seattle Cook/Atlanta COOK/SEER COOK/SanFranCook/Detroit Cook/Seattle Cook/Atlanta

Esophagus 1.05 1.11 1.11 0.87 1.05 1.04 0.94 0.85 0.97 1.16Stomach 1.50 1.36 1.36 1.71 2.00 1.01 1.13 0.95 1.00 0.98crc 1.07 1.06 1.06 1.11 1.31 1.09 1.11 1.02 1.25 1.09Liver 1.16 0.83 0.83 1.16 1.32 0.87 0.67 0.78 0.45 1.33Pancreas 1.11 1.09 1.09 1.04 1.33 1.06 1.08 0.91 1.21 1.30Lung and Bronchus 1.03 1.17 1.17 0.91 1.14 1.16 1.07 0.95 1.18 1.47Urinary Bladder 1.09 1.13 1.13 1.05 1.39 1.16 1.21 1.05 1.20 1.35Kidney and Renal Pelvis 1.09 1.25 1.25 0.98 1.28 1.04 1.03 0.96 0.96 1.02Brain 0.96 1.02 1.02 0.86 1.13 1.08 1.08 1.03 1.26 1.08Breast 0.95 0.88 0.88 0.87 1.00 1.01 1.00 1.00 1.00 0.97Cervix Uteri 1.31 1.47 1.47 1.21 1.33 1.76 2.56 1.39 2.60 1.74Corpus Uteri 1.13 1.16 1.16 1.14 1.55 1.12 1.16 1.03 1.12 1.29Ovary 1.08 1.02 1.02 1.01 1.04 1.00 0.97 1.00 1.28 0.89Hodgkin 0.97 0.93 0.93 1.00 1.04 0.96 0.75 0.96 0.60 1.09NHL 0.94 0.97 0.97 0.84 1.07 0.82 0.72 0.79 0.78 0.90MM 0.98 0.93 0.93 0.91 1.24 0.86 0.91 0.78 0.81 0.93leukemia 0.97 1.06 1.06 0.86 1.16 0.99 1.01 0.87 0.68 1.14IRR is >= 1.00

Excess Cancer in Men in Cook County

White Males Black MalesCOOK/SEER COOK/SanFranCook/Detroit Cook/Seattle Cook/Atlanta COOK/SEER COOK/SanFranCook/Detroit Cook/Seattle Cook/Atlanta

Esophagus 1.05 1.26 1.26 0.98 1.26 1.28 1.73 1.06 1.89 1.29Stomach 1.27 1.21 1.21 1.41 1.78 1.16 1.18 1.05 1.42 1.32crc 1.13 1.15 1.15 1.16 1.39 1.26 1.26 1.14 1.35 1.34Liver 1.20 0.95 0.95 1.17 1.46 0.88 0.69 0.84 0.58 1.16Pancreas 1.09 1.04 1.04 1.06 1.32 1.08 1.29 0.87 1.24 1.28Lung and Bronchus 1.07 1.36 1.36 1.02 1.18 1.13 1.24 0.95 1.22 1.25Urinary Bladder 0.97 1.02 1.02 0.93 1.16 1.00 0.88 0.87 0.88 1.29Kidney and Renal Pelvis 1.03 1.09 1.09 0.95 1.22 0.99 1.07 0.86 0.72 1.21Brain 0.88 0.94 0.94 0.90 1.04 1.02 1.25 0.88 0.90 1.41Prostate 0.93 0.94 0.94 0.88 0.98 1.00 1.13 0.96 1.05 0.89Testis 0.87 0.91 0.91 0.77 1.05 0.93 0.62 0.87 1.63 1.00Hodgkin 0.92 0.94 0.94 0.87 1.06 0.97 0.85 0.83 1.55 1.06NHL 0.96 0.88 0.88 0.86 1.06 0.83 0.89 0.83 0.86 0.77MM 0.93 0.87 0.87 0.84 1.06 0.87 0.94 0.80 0.73 1.01leukemia 0.93 0.96 0.96 0.84 1.21 1.01 0.95 0.93 1.09 1.14IRR is >= 1.00

COMPASS Broad Goals:

• Novel scientific discovery related to prevention and population

science

• Evaluate preventive interventions

• Evaluate health care and disparity related factors

• Create a long-term public health research resource

• Education and training tool for prevention and population

sciences

• Outreach, community engagement and population translation

• Ultimately improve the health of the population of Chicago and

beyond

Research Scope of COMPASS

Study Design

• Using a longitudinal cohort design.

• This means we will recruit a large random sample of Chicago population, will measure the factors mentioned above, and then follow them into the future for assessing health outcomes.

• We will compare the social, biological and contextual characteristics of the persons who get cancer and other chronic diseases to those who don’t.

COMPASS Pilot Phase [Funded by UCCCC]

• 3,000 residents representing City of Chicago population– 1,350 White– 1,350 African American– 600 Hispanic– 300 Asian

• ≥ 35 years• Ability to complete interview in English• Citizen or permanent resident

• Enrollment from mid-2013 in 40 Chicago Census Tracts

Where will they be recruited?Rogers Parktract 0103, population 6,236 West Ridgetract 0205, population 6,214 tract 0206.02, population 4,340 Lincoln Squaretract 0409, population 1,950 North Centertract 0502, population 4,837 Near North Sidetract 0804, population 4,317 tract 8422, population 2,603 Jefferson Parktract 1104, population 4,352 Albany Parktract 1403.01, population 2,891 Portage Parktract 1503, population 7,198 Irving Parktract 1606.1, population 3,490 Belmont Cragintract 1903, population 5,794 Logan Squaretract 2207.02, population 4,060 West Towntract 2424, population 2,764 Austintract 2521.02, population 6,438 North Lawndaletract 2909, population 4,530 tract 8433, population 1,228 tract 8434, population 1,451 South Lawndaletract 3012, population 4,012Near South Sidetract 3302, population 3,806

Armour Squaretract 8411, population 7,254 Douglastract 3510, population 3,267 Grand Boulevardtract 3819, population 1,295 Washington Parktract 4005, population 2,558 Calumet Heightstract 4801, population 2,033 Roselandtract 4907, population 3,085 tract 4908, population 4,007 tract 4913, population 2,886 West Pullmantract 5305.03, population 5,345 McKinley Parktract 8404, population 3,326 Bridgeporttract 8397, population 4,326 tract 8400, population 2,695 Gage Parktract 6305, population 6,364 West Lawntract 6606, population 6,333 West Englewoodtract 6704, populationAshburntract 7002, population 6,609 tract 7004.01, population 5,923 tract 7005.01, population 7,125 Washington Heightstract 7301, population 2,424 Edgewatertract 0305, population 6,395

Fieldwork

• Community engagement efforts and advance contacts with target participants

• Initial consenting/recruitment of subjects at their homes [supplemented with other methods as needed]

• In-person interview, physical measures, and biological sample by trained interviewer/phlebotomist

• Permission for follow-up and to access medical records

• Initial focus on cancer and chronic diseases (including CVD, diabetes and respiratory disease outcomes)

• $50 compensation for effort in participation

COMPASS Long-term Plan

• Seek external funding for project expansion

• Establish a multiethnic cohort of 100,000 adults representing population of Cook County

• Partnership with other Chicago academic and city/state institutions and private organizations

• Participate in national and international consortiums

• Enumerate children and family members for future broader child/family health studies

http://compass.uchicago.edu