commissioning the absl-3 laboratory - bcxa · 2016-09-28 · national conference on building...
TRANSCRIPT
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Presented by
Michael C. Rosenberg P.E.
Stanley Consultants, Inc.
Commissioning the ABSL-3 Laboratory
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Commissioning
• Modern research animal facilities are sophisticated buildings with the potential for considerable start-up problems. Commissioning a facility provides an exercise that test building systems and assures they are working properly before moving valuable animals and programs into the facility.
• The Commissioning Authority should be brought into the project team early in the project.
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Commissioning
• The Commissioning Authority should be part of the factory acceptance testing of major equipment.
• Consider assigning Test, Adjust, and Balance (TAB) contract to Commissioning Agent.
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Primary Elements of the ABSL-3 Lab
• Safety Practices
• Safety Equipment (Primary Containment)
• Facility Requirements (Secondary Containment)
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Biosafety in Microbiological and Biomedical Laboratories (BMBL)
• Provides guidelines for the safe use of hazardous agents.
• Fifth edition released in February 2007
• Available on the CDC web site at www.cdc.gov/od/ohs/biosafety/bmbl5/bmbl5toc/htm.
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
BMBL – New Edition
• Greater emphasis on biosecurity than previous.
• Risk management section expanded.
• Each facility should have its own biosafety manual with end users having access (exposure control plans).
• Increased emphasis on documenting proficiency
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
BMBL – New Edition
• Appropriate medical surveillance with risk assessment done annually.
• Expanded information on secondary barriers.
• Increased information on emergency procedures and medical aid.
• New chapters or sections on biosecurity, occupational health, decontamination of contaminated surfaces, and biological toxins.
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Safety Practices
• Policies and Procedures
• Training
• Access Limitations
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Safety Equipment (Primary Containment)
• Protective Clothing
• Gloves
• Eye and Respiratory Protection
• Ventilated Caging
• Bio-Safety Cabinets
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Facility Design (Secondary Barriers)
• Separated Areas
• Security
• Wall and Surface Design
• Ventilation
• Cage wash and Bedding Disposal
• Decontamination
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Traditionally Commissioned Equipment
• HVAC
• Electrical
• Plumbing
• Life – Safety
• Security
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Vivarium Equipment
• Caging Systems• Bio-Safety Cabinets• Cage, Bottle, Glass, Tunnel Washers• Decontamination• Animal Watering, Lighting, Monitoring• Bedding Disposal and Dispensing• Autoclaves• Compressed Air, Vacuum Systems
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Biohazard Caging
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Biohazard Caging
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Bio-Safety Cabinets
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Cage Wash Equipment
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Decontamination Equipment
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Animal Watering, Lighting, Monitoring
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Bedding Disposal and Dispensing
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Security / Access Control
• Biohazard Suite entry is card access.
• Access to ABSL2 Suites is by card access.
• BSL3/ABSL3 entry is by Biometric reader (air locks, labs, and animal rooms).
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Understanding Design Considerations “Basis of Design”
• Areas of Containment• Methods of Containment• Sealing Requirements• Visual and Audible Displays• Airflows and Pressure Relationships• Integrated Controls• Environmental Parameters• Cleaning and Sterilization
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Prefunctional Checklist• Laboratory Envelope and Containment
• Equipment Installation and Startup
• Calibration of Sensors, Actuators, etc.
• Integrated Controls Communications
• Hardwire and Software Interlocks
• Test and Balance
• Documentation
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Installation Observation
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Installation Observation
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Installation Observation
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Installation Observation
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Installation Observation
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Room Pressurization Monitoring
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Room Pressurization Monitoring
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Decontamination Control
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Decontamination
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Functional Testing and Verification
• Pressurization and Airflows
• Temperature and Humidity Control
• Damper and Valve Operations
• Sensor Calibrations
• Proper Alarming Parameters
• Interlocks
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Functional Testing
• Alarm Reporting and Annunciation
• Security and Procedural Interlocks
• Decontamination Procedures
• Redundant Equipment Operation
• Equipment Failure Interlocks
• Operation Under Standby Power
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Functional Testing
• Operation of Vacuum and Compressed Air Systems
• Operation of Autoclaves and Washers
• Operation of Bedding Systems
• Document Sequences of Operations
• Trend Monitoring Points
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Problem Resolution / Retesting
• Detailed Documentation
• Team Communications
• Timely Resolution
• Retest if Necessary
• Document Closure
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Training
• Maintenance Personnel
• Users
• Operations and Maintenance Manuals
• Record Drawings
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Commissioning Report
• Executive Summary
• Final Control Parameters
• Documentation Back Up
• Warranty Follow-up
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National Conference on Building Commissioning 2007
Michael Rosenberg: Commissioning the ABSL-3 Laboratory
Thank You
Questions?