n Zhixing Kevin Pan, MD, PhDn Professor and Interim Chairman, Department of

Medical Microbiology and Immunology, Director Infection, Immunity & Transplan-tation, College of Medicine, University of Toledo Health Science Campus, USA

n “The Endogenous Negative Regulators: Potential Drug Targets for Treatment of

Inflammatory Diseases”

Venue: Hygiene Institute, Lecture Hall 1,Kinderspitalgasse 15, Vienna IX

Time: Monday July 4, 2016, 14.00 pm

Host: Hannes Stockinger

Centre for Pathophysiology, Infectiology and Immunology -Medical University of Vienna

CENTRE FOR PATHOPHYSIOLOGY, INFECTIOLOGY AND IMMUNOLOGYMEDICAL UNIVERSITY OF VIENNAINTERNET: WWW.MEDUNIWIEN.AC.AT/CePII

COLLOQUIUM IN PATHOPHYSIOLOGY, INFECTIOLOGY AND IMMUNOLOGY

BiosketchZhixing Kevin Pan

Centre for Pathophysiology, Infectiology and Immunology -Medical University of Vienna

n Zhixing Kevin Pan received his M.D. and Ph.D. in 1991 at the ShanghaiSecond Medical University. After postdoctoral training in the Department ofImmunology, the Scripps Research Institute (La Jolla, California, USA), heestablished his own laboratory (Assistant Professor) in the Department of Molecularand Experimental Medicine, The Scripps Research Institute in 2000. Dr. Panrelocated his laboratory to the Department of Medical Microbiology andImmunology, Medical College of Ohio as Associate Professor in 2003 and waspromoted to Professor with Tenure in 2006. His research has been supportedcontinuously by multiple grants from the National Institutes of Health (NIH). Themain research interest of Dr. Pan's laboratory is to better understand the molecularmechanisms by which host cells recognize microbial products thereby initiatinginflammatory responses. In fact, his group has successfully characterized: a) rolesfor NF-kappaB in GPCR signaling; b) function of Rho in leukocyte responses tobacterial products; and c) signaling pathway for TLR4-dependent response to LPS.Dr. Pan has made these major discoveries by using the most advanced cutting-edge technologies, including transgenic and knockout mice, siRNA-mediated genesilencing, and cell-based reporter system to monitor activation of NF-kappaB andother transcription factors. His work has formed a conceptual framework for ourcurrent understanding of host innate immunity against microbial pathogens and thepatho-physiology of inflammatory diseases. In fact, some of these discoveries maylead to the development of new biomarkers and therapeutics.

n 5 Key Publicationsn Pan, Z., Kravchenko, V.V.,Ye, R.D. Platelet-activating factor stimulates transcription of the

heparin-binding EGF-like growth factor in monocytes. Correlation with an increased NF-kBbindingactivity.J.Biol.Chem.270:7787,1995.

n Pan, Z.K., Zuraw,B., Lung,C. Prossnitz,E.R., Browning,D.D., Ye, R.D. Bradykininstimulates NF-kB activation and cytokine gene expression in cultured human fibroblasts.J. Clin. Invest. 98:2042,1996.

n Ptasznik,A. E., Chinta, S. C., Costa, M. A., Kalota, A. A., Swider, C. R., Katz, B. A., Demir,G. C., Pan, Z. K., Gewirtz, A.M. G protein-coupled chemokine receptor signaling through aScr family kinase in normal andmaliganthematopoietic cells.J.Exp.Med. 196:667,2002.

n Chen, L-Y, Pan, W.W., Chen, M., Li, J-D., Liu, W., Chen, G., Huang, S., Papadimos, T.J.,and Pan, Z.K. Synergistic induction of inflammation by bacterial products LPS and fMLP:An importanatmicrobialpathogenicmechanism. J. Immunol. 182 :2518,2009.

n Hong S, Noh H,Chen H, Padia R, Pan ZK, Su SB, Jing Q, Ding HF,Huang S. Signaling byp38 MAPK stimulates nuclear localization of the microprocessor component p68 forprocessing of selectedprimarymicroRNAs. Science Signal. 2013 ra16.