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College of Engineering and Science Updated Nov., 8th 2015

RESUME Frank Alexis, Ph.D.

PERSONAL DATA

Associate Professor

Department of Bioengineering

203 Rhodes Engineering Research Center

Clemson University

Clemson, SC 29634

864-656-5003

EDUCATION

Ph.D., Nanyang Technological University, 2005, Materials Science

Engineering.

M.S., Technological University of Montpellier, 2000, Materials Science

and Interfaces.

B.S., Technological University of Montpellier, 1999, Chemistry.

PROFESSIONAL EXPERIENCE

Clemson University, 2015-, Associate Professor of Bioengineering

Nanyang Technological University, 2015-, Visiting Associate Professor,

School of Chemical and Biomedical Engineering

Clemson University, 2009-, Assistant Professor of Bioengineering

Massachusetts Institute of Technology, 2006-2009, Research Associate,

Department of Health Science and Technology.

Brigham and Women’s Hospital, 2006-2009, PostdocFellow, Laboratory

of Biomaterials and Nanomedicine.

CONSULTING EXPERIENCE

Stericoat Inc., Cambridge, Massachusetts (2008), assisted for the

development of novel implant coatings.

LEK Consulting, Los Angeles, California (2014), assisted for providing

insights drug delivery technologies.

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Polymed Inc., Clemson, South Carolina (2015-), assisting for the

development of novel drug delivery product.

MEMBERSHIPS

Member, Biomedical Engineering Society, BMES (2014-)

Member, Society For Biomaterials, SFB (2009- 2012)

Member, American Chemical Society, ACS (2008-2012)

Member, Society of Chemical Industry, SCI (2004- )

PROFESSIONAL ACTIVITIES

Reviewer Journals:

2006-: ASM International

2008-: Molecular Pharmaceutics, Biomacromolecules, Cancer

Epidemiology, Cancer Research.

2009-: Molecular Cancer Therapeutics, Bioconjugates Chemistry, Journal

of Biomedical Materials Research: Part A, Journal of Biomaterial Science:

Polymer Edition.

2010-: Ocular Pharmacology and Therapeutics, Royal Society for

Chemistry, Therapeutic Delivery, Trends in Molecular Medicine,

Advanced Functional Materials, Chemical Papers, Chemistry an Asian

Journal.

2011-: ChemPhysChem, Journal of Biomedical Materials Research: Part

B, European Journal of Pharmaceutics and Biopharmaceutics; Advanced

Materials.

2012-: Nanomedicine, Small, Acta Biomateriala, Langmuir, Expert

Opinion in Drug Delivery, Journal of Nanotechnology, Journal of

Visualized Experiments, Materials, Polymer Degradation and Stability,

Military Medicine.

2013-: ACSNano, Advanced Eng. Mat., Advanced Healthcare Mat., Drug

Discovery Today, Expert Reviews Medical Devices, Open Journal of

Biomedical Research, SCIKNOW, Tissue Engineering.

2014-: Chemical Reviews, Pharmaceutical Patent Analyst, Nanoscale,

Biomaterials, Materials Today, Drug Delivery, International Journal of

Nanomedicine, Archive Medical Research, Drug Delivery and

Translational Research, Journal of Materials Chemistry B, ACS Applied

Materials and Interfaces, International Journal of Pharmaceutics,

Biofabrication, Journal of Bioprocessing and Biotechniques, Analytical

Methods, Colloids and Surfaces Interfaces B, ACS Sustainable Chemistry

and Engineering, Journal of Nanotechnology Nanomedicine and

Nanobiotechnology, International Journal of Molecular Science,

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PLOSONE, Materials and Engineering Part B, Clinical Pharmacology and

Therapeutics.

2015-: Current Neuropharmacology, Current Cancer Drug Targets,

Journal of Controlled Release, Journal of Alloys and Compounds,

Polymer, Angewandte Chemie, ChemNanoMat, Molecular Cancer

Therapeutics, ChemElectroChem, ACS Chemical Biology, Biomaterials,

Applied Surface Science, Chemical Reviews, Nanotoxicology, Applied

Surface Science, Journal of Carbon Research.

2016: ACS Chemical Biology, RCS Chemical Science.

Reviewer Grants/Scholarships:

2004: Singapore A*Star Government Scholarship

2009-: US Army Medical Research and Materiel Command (USAMRMC)

2010: ORAU

2012-: National Science Foundation-Major Research Instrumentation,

Singapore-MIT Alliance for Research and Technology Innovation Grant,

Fonds Recherche Québec - Nature et technologies (FRQNT), American

Association for the Advancement of Science (AAAS), INDO-US

SCIENCE & TECHNOLOGY.

2013-: DoD-PRMRP, Nanyang Technological University-Singapore-Tier

1.

2014-: DoD-BCRP-Nano, Nanyang Technological University-Singapore-

Tier 1.

2015-: DoD-BCRP-Nano, NTU A-Star-Career Development Award,

Nanyang Technological University-Singapore-Tier 1.

Reviewer Books:

2005: Encyclopedia of Biomaterials and Biomedical Engineering, G. E

Wneck and G.L Bowlin. Marcel Dekker, NY.

2013: CRC Book

Reviewer Conferences:

2004: Singapore Science and Engineering Fair

2008-: Nano Science and Technology Institute Conference

2011-: Biomedical Engineering Society Conference, National Conference

for Undergraduate Research, Biomedical Engineering Society Conference

Symposium/Conference Organizer:

2012: Clemson’s Biomaterials Day-Society For Biomaterials,

International Organizing Committee of the IUPAC MacroMolecular

Complexes Conference.

PUBLICATIONS

Book Chapter N=7

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Kolishetti, N., Alexis, F., Pridgen, E., Farokhzad, O. C., Nanoplatform-Based Molecular

Imaging, 1st edition (2011), John Wiley and Sons, Inc., Hoboken, NJ.

Rosen, Y., Mattix, Rao A., Alexis, F. Nanomedicine in Health and Disease, 1st edition

(2011), Taylor and Francis Group, LLC, Boca Raton, FL.

Moore, T., Graham, E., Mattix, B., Alexis, F., Biomaterials Science: An Integrated

Clinical and Engineering Approach, 1st edition (2012), Taylor and Francis Group, LLC,

Boca Raton, FL.

Venkatraman, S.; Keith, K.; Rosen, Y.; Huang, Y.; Steele, T.W.J.; Alexis, F., Polymers

for Vascular and Urogenital Applications, 1st edition (2012), Taylor and Francis Group, LLC, Boca Raton, FL.

Prior to Clemson:

Alexis, F.; Zeng, J.; Wang, S., Gene Transfer: Delivery and Expression of DNA and

RNA, A Laboratory Manual, 1st edition (2007), Cold Spring Harbor Laboratory Press,

New York, NY.

Pridgen, E.; Alexis, F.; Farokhzad, O. C.; Langer, R., Methods in Bioengineering Book

Series Nanoscale Bioengineering and Nanomedicine, 1st edition (2009), Artech House ,

Boston, MA.

Alexis, F.; Pridgen, E.; Langer, R.; Farokhzad, O. C., Handbook of Experimental

Pharmacology 197, 1st edition (2010), Springer, Berlin, Germany.

Referred Journal Publications N=54

Loo, S.C.J., Moore, T., Banik, B., Alexis, F., “Biomedical Applications of Hydroxyapatite

Nanoparticles”, Current Pharmaceutical Biotechnology 11, 333-342 (2010).

Zha, L., Banik, B., Alexis, F., “Stimuli Responsive Nanogels”, Soft Matter 7, 5908-5916

(2011).

Stone, R., Willi, T.J., Mefford, T., Rosen, Y., Alexis, F., “Targeted Magnetic

Hyperthermia”, Therapeutic Delivery 2, 815-838 (2011).

Banik, B., Alexis, F., “Spatial Functionalization of Polymeric Films”, Cover page of

Biomaterials Forum 33, 3, (2011).

Xiao, Z., Levy-Nissenbaum, E., Alexis, F., Lupták, A., Teply, B.A., Chan, J.M., Shi, J.,

Digga, E., Cheng, J., Langer, R., Farokhzad, O.C., “Engineering of Targeted

Nanoparticles for Cancer Therapy Using Internalizing Aptamers Isolated by Cell-Uptake

Selection”, ACS Nano 6, 696-704 (2012).

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Chen, H., Colvin, D. C., Qi, B., Moore, T., He, J., Mefford, O. T., Alexis, F., Gore, J. C.,

Anker, J. N., “Magnetic and optical properties of multifunctional core-shell

radioluminescence nanoparticles”, J. Mat. Chem. 22, 12802-12809 (2012).

Chen, H., Moore, T.; Qi, B.; Colvin, D.C.; Jelen, E.; Hitchcock, D.A.; He, J.O.; Mefford,

T.; Gore, J.C.; Alexis, F.; Anker, J.N. “Monitoring pH-triggered Drug Release from

Radioluminescent Nanocapsules with X-ray Excited Optical Luminescence.” ACS Nano,

7, 1178-1187 (2013).

Podila, R.; Moore, T.; Alexis, F.; Rao, M.A. “Graphene coatings for enhanced hemo-

compatibility of nitinol stents”. RSC Advances , 3, 1660-1665 (2013).

Podila, R.; Moore, T.; Alexis, F.; Rao, M.A. “Graphene Coatings for Biomedical

Implants”. Journal of Visualized Experiments, 73, e50276 (2013)

Moore, T.L., Pitzer, J., Podila,

R., Wang,

X., Lewis, R.L., Grimes S.W., Wilson, J.R.,

Skjervold, E., Brown, J., Rao, A., Alexis, F., “Polymer Coated Carbon Nanotubes to

Safely Deliver Drugs”, Particles and Particle Systems Characterization, 30, 299 (2013).

Moore, T.L., Pitzer, J., Podila,

R., Wang,

X., Lewis, R.L., Grimes S.W., Wilson, J.R.,

Skjervold, E., Brown, J., Rao, A., Alexis, F. Cover Art in Particles and Particle Systems

Characterization, Vol 30 (2013).

Chi, A.; Clayton, K.; Burrow, T.J.; Lewis, R.; Luciano, D.; Alexis, F.; D’hers, S.; Elman,

NM; “Intelligent drug-delivery devices based on micro- and nanotechnologies”.

Therapeutic Delivery, 4, 77-94 (2013)

Pridgen, E.M., Alexis, F., Kuo, T.T., Levy-Nissenbaum, E., Blumberg, R.S., Langer, R.,

Farokhzad, O.C., “Transepithelial Transport of Fc-Targeted Nanoparticles Across the

Intestinal Epithelium Barrier by the Neonatal Fc Receptor for Oral Delivery”, Science

Translational Medicine, 5, 213 (2013).

Mattix, B.; Poole, T.; Casco, M.; Uvarov, O; Visconti, R. P.; Simionescu,

D.; and Alexis

F.

“Small Diameter Vascular Grafts: Replacement Strategies, Maturation Techniques, and

Challenges”, Journal of Tissue Science & Engineering, 4, 1 (2013).

Mattix, B., Moore, T., Uvarov, O., Pollard, S., O'Donnell, L., Park, K., Horne, D.,

Dhulekar, J., Olsen, T., Duong, N.; Burg, K.; Kraveka, J., Alexis, F. “Effects of Polymeric

Nanoparticle Surface Properties on Interaction with Brain Tumor Environment for Drug

Delivery Applications”. NanoLife, 3, 1343003 (2013)

Mattix, B.; Olsen, T.R.; Moore, T; Casco, M.; Simionescu, D.; Visconti, R; Alexis,

“Accelerated Iron Oxide Nanoparticle Degradation Mediated by Polyester Encapsulation

for Tissue Engineering Into Cellular Spheroids”. Adv. Funct. Mat., 24, 800-807 (2014)

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Chen, H.; Qi, B.; Moore, T.; Colvin, D.C.; Gore, J.C.; Alexis, A.; Mefford, O.T.; and

Anker, J.N.” Synthesis of brightly PEGylated luminescent magnetic up-conversion

nanophosphors for deep tissue and dual MRI imaging. Small, 10, 160-168 (2014).

Mattix, B.; Olsen, T.R.; Gu, Y.; Casco, M.; Herbst, A.; Simionescu, D., Visconti, R. P.,

Kornev, K.G.; and Frank Alexis, “Biological Magnetic Cellular Spheroids as Building

Blocks for Tissue Engineering”, Acta Biomateriala, 10, 623-629 (2014).

Mattix, B.; Olsen, T.R.; Casco, M.; Reese, L.; Poole, L.T.; Zhang, J.; Visconti, R.;

Simionescu, A.; Simionescu, D.; Alexis, F. “Janus Magnetic Cellular Spheroids for

Vascular Tissue Engineering”, Biomaterials, 35, 949-960 (2014).

Moore, T.L., Podilakrishna, R.; Rao, A.; Alexis, F. “Systemic Administration of Polymer-

Coated Nano-Graphene to Deliver Drugs to Glioblastoma”, Particle and Particle Systems

Characterization, In Press, Covert Art, (2014).

Moore, T.L.; Grimes, S.W.; Lewis, R.L.; Alexis, F.“Multilayered Coated Carbon

Nanotube to Deliver Dasatinib”. Mol. Pharm., 11, 276-282 (2014).

Moore, T.; Chen, H.; Morrison, R.; Wang, F.; Anker, J.N., Alexis, F. “Nanotechnologies

for Non-invasive Measurement of In Vivo Drug Release”. Mol. Pharma., 11, 24-39 (2014)

Ilyinskii, P.O., Roy, C.J.; O’Neil, C.P.; Browning, E.A.; Pittet, L.A.; Altreuter, D.H.;

Alexis, F.; Tonti, E.; Shi, J.; Basto, P.A., Radovic-Moreno, A.F.; Iannacone, Langer, R.S.,

Farokhzad, O.C.; von Andrian,U.H.; Johnston, L.P.M.; and Kishimoto, T.K. “Adjuvant-

Carrying Synthetic Vaccine Particles Augment the Immune Response to Encapsulated

Antigen and Exhibit Strong Local Immune Activation without Inducing Systemic

Cytokine Release”. Vaccine, 32, 2882-2895 (2014).

Alexis, A.; and Anker, J.N.”Theranostic nanotechnologies: moving beyond imaging the

localization of the drug”. Therapeutic Delivery (Editorial), 5, 97-100 (2014).

Chen H, Sulejmanovic D, Moore T, Colvin DC, Qi B, Mefford OT, Gore JC, Alexis F,

Hwu SJ, Anker JN. “Iron-Loaded Magnetic Nanocapsules for pH-Triggered Drug Release

and MRI Imaging.” Chem Mater., 26, 2105-2112 (2014).

Chen H, Qi B, Moore T, Wang F, Colvin DC, Sanjeewa LD, Gore JC, Hwu SJ, Mefford

OT, Alexis F, Anker JN. “Multifunctional Yolk-in-Shell Nanoparticles for pH-triggered

Drug Release and Imaging.” Small, 10, 3364-3370 (2014)

Alexis F. “Nano-polypharmacy to treat tumors: coencapsulation of drug combinations

using nanoparticle technology.”Mol Ther., Commentary Article, 22, 1239-1240 (2014)

Olsen, R.T.; Alexis, F.; “Bioprocessing of Tissues using Cellular Spheroids”, Journal of

Bioprocessing and Biotechniques, Editorial, 4, e112 (2014)

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Pridgen EM, Alexis F, Farokhzad OC. “Polymeric Nanoparticle Technologies for Oral

Drug Delivery.” Clin Gastroenterol Hepatol., 12, 1505-1510 (2014)

Moore, T.L.; Wang, F.; Chen, H.; Grimes, S.W.; Anker, J.N.; Alexis, F.; "Polymer Coated

Radioluminescent Nanoparticles for Imaging Drug Delivery into Cells". Adv. Funct. Mat.,

37, 5815-5823 (2014).

Olsen, T. R., Mattix, B., Casco, M.; Herbst, A., Williams, C., Tarasidis, A., Evans, G.,

Jenkins, L., McMahan, C.L., Simionescu, D., Visconti, R.P., Alexis, F.; Processing

cellular spheroids for histological examination. Journal of Histotechnology, 37, 138-142

(2014)

Olsen, T. R., Casco, M.; Mattix, B., Herbst, A., Williams, C., Tarasidis, A., Evans, G.,

Jenkins, L., McMahan, C.L., Simionescu, D., Visconti, R.P., Alexis, F. “Preparing and

Processing Complex Tissue Constructs Composed of Cellular Spheroids”. Journal of

Cytology and Tissue Biology. 1: 002 (2014)

Olsen, T.R., Davis, L.; Nicolau, SE; Duncan, C.C.; Whitehead, D.C.; Van Horn, B.A.; and

Alexis, F.; “Non-Invasive Deep Tissue Imaging of Iodine Modified Poly(caprolactone-co-

1-4-oxepan-1,5-dione) Using X-Ray”. Acta Biomaterialia, 20, 94-103 (2015).

Pridgen EM, Alexis F, Farokhzad OC. “Polymeric Nanoparticle Drug Delivery

Technologies for Oral Delivery Applications.” Expert Opinion Drug Delivery., 12, 1459-

1473 (2015).

Nicolau, SE; Davis, L.; Duncan, C.C.; Olsen, T.R., Alexis, F.; Whitehead, D.C.; Van

Horn, B.A.. “An Oxime Graft Strategy for Iodinated Poly(epsilon-caprolactone) X-ray

Opaque Materials. Journal of Polymer Science: Polymer Chemistry Part A, 53, 2421-2430

(2015).

Casco, M., Olsen, T. R., Herbst, A., Grace Evans , Taylor Rothermel , Lauren Pruett

Simionescu, D., Visconti, R. P., Alexis, F. “Iron Oxide Nanoparticles Stimulates Extra-

Cellular Matrix Production into Cellular Spheroids”, Acta Biomaterialia, Submitted

(2015).

Campbell, McKenzie L. Guerra, Fernanda. D.;Dhulekar, Jhilmil; Alexis, Frank;

Whitehead, Daniel. C.; “Target-Specific Capture of Enviromentally Relevant Gaseous

Aldehydes and Carboxylic Acids with Functional Nanoparticles.” Chemistry, 21, 14834-

42 (2015).

Timothy R. Olsen, Megan Casco, Austin Herbst, Grace Evans, Taylor Rothermel, Lauren

Pruett, Jared Reid, Kelly Berry, Michael P. Jaeggli, Dan T. Simionescu, Richard P.

Visconti, and Frank Alexis.” Longitudinal Stretching for Maturation of Vascular Tissues

Using Magnetic Forces”. Cardiovascular Engineering and Technology, Submitted (2015).

Guerra, F. D.; Whitehead, Daniel. C., Alexis, F. ”Nanotechnology in Environmental

Remediation: Current Status and Challenges”, Submitted (2015).

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Prior to Clemson:

Alexis, F., Rath, S. K., Boey, F.Y.C., Venkatraman, S.,"Study of the Initial Stages of

Drug Release from a Degradable Matrix of Poly (d,l-lactide-co- glycolide)", Biomaterials

25, 813-821 (2004).

Alexis, F., Rath, S. K, Venkatraman, S., “In Vitro Study of Release Mechanisms of

Paclitaxel and Rapamycin from Drug-Incorporated Biodegradable Stent”, Journal of

Controlled Release 98, 67-74 (2004).

Alexis, F., Rath, S. K., Boey, F.Y.C., Venkatraman, S., “Controlled drug release of

bioerodible polymers: effect of drug type and composition”, Journal of Controlled

Release 102, 333-344 (2005).

Alexis, F., "Factors Affecting Degradation and Drug Release Mechanisms of Bioerodible

Polymers", Polymer International 54, 36-46 (2005).

Tang, G.P., Zeng, S., Alexis, F., Yang, Y.Y., Wang, S., “Low Molecular Weight

Polyethylenimine Copolymerized with B-cyclodextrin for Gene Delivery”, Journal of

Gene Medicine 8, 736-744 (2006).

Alexis, F., Rath, S. K., Gan, L-H., Venkatraman, S.,”Some Insight into Hydrolytic

Scissions Mechanisms in Bioerodible Polyesters”, Journal of Applied Polymer Science

102, 3111-3117 (2006).

Alexis, F., Lo, S.L., Wang, S., “Covalent Attachment of Low Molecular Weight

Polyethylenimine Improves Tat-Peptide Mediated Gene Delivery", Advanced Materials

18, 2174-2178 (2006).

Zhang, L., Radovic-Moreno, A., Alexis, F., Gu, F.X., Basto, P., Langer, R, Farokhzad, O.

C., “Co-Delivery of Hydrophobic and Hydrophilic Drugs from Nanoparticle-Aptamer

Bioconjugates”, ChemMedChem. 2, 1268-1271 (2007).

Gu, F.X., Karnik, R., Wang, A. Z., Alexis, F., Levy-Nissenbaum, E., Hong, S., Langer,

R., Farokhzad, O. C.,” Targeted Nanoparticles for Cancer Therapy”, NanoToday 2, 14-21

(2007).

Alexis, F., Basto, P., Levy-Nissenbaum, E., Radovic-Moreno, A., Zhang, L., Langer, R.,

Molnar, L., Farokhzad, O. C.,”HER-2 Targeted Nanoparticle-Affibody Bioconjugates for

Breast Cancer Therapy“, ChemMedChem. 3, 1839-1843 (2008).

Zhang, L., Chan, J. M., Gu, F.X., Rhee, J-W., Wang, A.Z., Radovic-Moreno, A., Alexis,

F., Langer, R, Farokhzad, O. C., “Self-Assembled Lipid-Polymer Hybrid Nanoparticles:

A Robust Drug Delivery Platform”, ACS Nano 2, 1696-1702 (2008).

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Alexis, F., Radovic-Moreno, A., Rhee, J-W, Richie, J. P., Langer, R., Farokhzad, O. C.,

"New Frontiers in Nanotechnology for Cancer Treatment", Journal of Urological

Oncology 26. 74-85 (2008).

Wang, A. Z., Bagalkot, V., Vasilliou, C., Gu, F.X., Alexis, F., Zhang, L., Shaikh M.,

Yuet, K. , Cima, M., Langer, R., Farokhzad, O. C., Kantoff, P.W., Bander, N.H., Jon, S.,

Farokhzad, O. C., "Superparamagnetic Iron Oxide Nanoparticle-Aptamer Bioconjugates

for Combined Prostate Cancer Imaging and Therapy”, ChemMedChem. 9, 1311-1315

(2008).

Alexis, F., Pridgen, E., Langer, R., Farokhzad, O. C., "Factors Affecting the Clearance

and Biodistribution of Polymeric Nanoparticles", Molecular Therapeutics 5, 505-515

(2008).

Conference Proceedings: (Peer Reviewed)

Banik, B.L., Rogers, M., Dhulekar, J., Moore, T.L., Alexis, F., “Synthesis and Testing of

Biomolecules to Target Bone”, Proceedings of the National Conference of

Undergraduate Research, Ithaca College, Ithaca, NY, (2011).

Banik, B.L., Rogers, M., Dhulekar, J., Moore, T.L., Alexis, F., “Synthesis and Testing of

Biomolecules to Target Bone”, Proceedings of the ACC Meetings of Minds, University of

Miami, Miami, FL, (2011).

Keith, K., Mattison, S., Collier, M., Lewis, R., Alexis, F. “Testing Chemotherapeutic

Drugs for Synergistic Toxicity Using Several Cancer Cell Lines”, Proceedings of the

ACC Meetings of Minds, University of Miami, Miami, FL, (2011).

Wright-Walker, C. J., DesJardins, J. D., Alexis, F., LaBerge, M., “Tribological

Evaluation of a Drug Enriched Ultra-High Molecular Weight Polyethylene for Enhanced

Total Joint Replacement Bearing Surface Functionality”, Proceedings of the Society For

Biomaterials Meeting, Orlando, FL, (2011).

Mattix, B., Reese, L., Pollard, S., Anderson, J., Carpenter, K., Davda, L., Breece, J.,

Alexis, F.”Effects of Polymeric Nanoparticle Surface Properties on Interaction with Brain

Cancer Cells”, Proceedings of the Southeast Regional IDeA Meeting, New Orleans, LA,

(2011).

Mattix, B., Uvarov, O., Willi, T., Reese, L., Pollard, S., Frankel, B., Alexis, F. “ Effects

of Polymeric Nanoparticle Surface Properties on Interaction with Brain Tumor

Environment”, Proceedings of the SC INBRE Scientific Symposium, Columbia, SC,

(2012).

Mattix, B., Reese, L., Poole, T., Visconti, R., Simionescu, D., Simionescu, A., Jenkins,

L., Bruce, T., Alexis, F. “Assembly of Engineered Blood Vessels Using Magnetic

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Forces.” Proceedings of the SC Project for Organ Biofabrication Scientific Symposium,

Columbia, SC, (2012).

Poole, T., Mattix, B, Reese, L., Alexis, F. “Magnetic Spheroids For Tissue Engineering

Applications.” Proceedings of the National Conference on Undergraduate Research,

Weber State University, Ogden, Utah, (2012).

Wright-Walker, C. J.; Golightly, C. E.; Alexis, F.; DesJardins, J. D.; LaBerge, M.;

“Tribological Evaluation of a Drug Enriched Ultra-High Molecular Weight

Polyethylene for Enhanced Total Joint Replacement Bearing Surface Functionality”;

Proceedings of the Society For Biomaterials Conference, New Orleans, (2012).

Moore, T. L.; Stoner, B.; Morrison, R.; Simionescu, A.; Simionescu, D.; Recknor, C.;

Alexis, F.; “Targeted, Multifunctional Nanoparticles for Controlled Delivery of Anabolic

Bone Therapy Drugs”. Proceedings of the Society For Biomaterials Conference, New

Orleans, (2012).

Mattix, B.; Poole, T.; Casco1, M.; Visconti, R.; Simionescu, D.; Simionescu, A.;

Alexis, F.; “Spatial Control of Magnetic Nanoparticles Integrated with Cellular Spheroids

as Tissue Engineered Building Blocks”. Proceedings of the Society For Biomaterials

Conference, New Orleans, (2012).

Dawson, B.; “Periorbital Implant for Treatment of Cytomegalovirus”. Proceedings of the

South Carolina-Louis Stoke Alliance for Minority Participation (LSAMP) Conference,

Columbia, (2012).

Horne, D.; “Effects of Polymeric Nanoparticle Surface Properties on Interaction with

Brain Tumor Environment”. Proceedings of the South Carolina-Louis Stoke Alliance for

Minority Participation (LSAMP) Conference, Columbia, (2012).

Alexis, F.; “Polymer Coated CNTs to Safely Delivery Drugs”. Proceedings of the ACS

SERMACS Meeting, Raleigh, (2012).

Uvarov, O.; Mattix, B.; Pollard, S.; O’Donnel, L.; Horne, D.; Dhulekar, D.; Frankel, B.

Alexis, F.”An Investigation of Functionalized Nanoparticles Interactions with Brain

Cancer Cells” .I”. Proceedings of the ICMAT, Singapore, (2012)

Moore, T.; Morrison, R.; Stoner, B.; Simionescu, A.; Simionescu, D.; Recknor, C.;

Alexis, F. “Targeted, Multifunctional Nanoparticles for Controlled Delivery of Anabolic

Bone Therapy Drugs.”Proceedings of the Biomedical Engineering Society Annual

Meeting, Atlanta, (2012).

Mattix, B.; Poole, T.; Casco1, M.; Visconti, R.; Simionescu, D.; Simionescu, A.;

Alexis, F. “Spatial Control of Magnetic Nanoparticles Integrated with Cellular Spheroids

as Tissue Engineered Building Blocks”. Proceedings of the Biomedical Engineering

Society Annual Meeting, Atlanta, (2012).

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Chen H., Moore T., Qi B., Colvin D.C., Jelen E., Hitchcock, D., He J., Mefford O.T.,

Gore J.C., Alexis F., Anker J.N., “Monitoring pH-triggered drug release from

radioluminescent nanocapsules with X-ray excited optical luminescence,” Proceedings of

the ACS SERMACS Meeting, Raleigh, (2012).

Alexis, F. “Drug Delivery and Imaging Technologies Using X-Ray”, ICMAT, Singapore,

(2013).

Olsen, T., Alexis F.; “Cellular Spheroid Fusion Using Magnetic Forces to Fabricate a

Vascular Tissue”, Society For Biomaterials, (2013).

Olsen, T., Casco, M., Simionescu, D., Visconti, R., Alexis, F.”Accelerating Cellular

Spheroid Fusion Using Magnetic Forces to Fabricate a Vascular Tissue "Blood Vessel

Tissue Engineering", Accepted. Biomedical Engineering Society, San Antonio, Accepted

(2014).

Olsen, T., Whitehead, D., Van Horn, B., Alexis, F. ”Non-Invasive Deep Tissue Imaging

of Polymer Degradation Using X-Ray”, Accepted. Biomedical Engineering Society, San

Antonio, Accepted (2014).

Prior to Clemson:

Alexis, F., Rath, S. K., Boey, F.Y.C., Venkatraman, S., “Factors Affecting the Drug

Release Mechanisms of PLGA 53/47 and PLLA”, Proceedings of the International

Conference of Materials Processing for Properties and Performance (MP3), Singapore,

Singapore, (2002).

Alexis, F., Rath, S. K., Boey, F.Y.C., Venkatraman, S., “Comparative Study of Drug

Release from Matrices Made of PLLA and PLGA Copolymers”; Proceedings of the

International Conference on Materials for Advanced Technologies, Singapore,

Singapore, (2003).

Alexis, F., “HER-2 Targeted Nanoparticle-Affibody Bioconjugates for Breast Cancer

Therapy”, Proceedings of the American Association Cancer Research Annual Meeting,

Los Angeles, CA, (2007).

Alexis, F., “HER-2 Targeted Polymeric Nanoparticles for Breast Cancer Therapy”,

Proceedings of the Nano Science and Technology Institute Conference, Santa Clara, CA,

(2007).

Conference Proceedings (Not reviewed)

Banik, B.L., Rogers, M., Moore, T.L., Alexis, F., “Synthesis and Testing of Biomolecules

to Target Bone”, Southeast Biomedical Engineering Career Conference, Clemson, SC,

(2010).

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Moore, T., Przestrzelski, B., Lewis, R., Jelen, E., Dhulekar, J., Stoner, B., Bloomquist,

C., Simionescu, D., Simionescu, A., Recknor, C., Alexis, F. “Targeted Nanoparticles to

Deliver Drugs for Prolonged Periods of Time to Bone Tissue.”, SCMEDTECH

Conference, Charleston, SC, (2011).

Stoner, B., Morrison, R., Przestrzelski, B., Dhulekar, J., Lewis, R., Jelen, E., Moore, T.,

Simionescu, D., Simionescu, A., Recknor, C., Alexis. F., “Targeted Nanoparticles to

Deliver Drugs Through Controlled Release Kinetics to Bone Tissue”, SFB-Memphis

Biomaterials Day, University of Memphis, Memphis, TN, (2011).

Reese, L., Mattix, B., Poole, T., Visconti, R., Simionescu, D., Simionescu, A., Jenkins,

L., Bruce, T., Alexis, F., “ Magnetic Cell Spheroid For Tissue Engineering Applications”,

SFB-Clemson University Biomaterials Day, Clemson University, Clemson, SC, (2011).

Poole, T., Mattix, B., Reese, L., Visconti, R., Simionescu, D., Simionescu, A., Jenkins, L.

Bruce, T., Alexis, F., “Magnetic Spheroids For Tissue Engineering Applications”,

Southeast Biomedical Engineering Career Conference, University of Virginia, Herndon,

VA, (2011).

Uvarov, O., Mattix, B., Willi, T., Reese, L., Pollard, S., Frankel, B., Alexis, F.” Effects of

Polymeric Nanoparticle Surface Properties on Interaction with Brain Tumor

Environment”, SFB- Memphis Biomaterials Day, University of Memphis, Memphis, TN,

(2012).

Moore, T.L.; Britton, T.; Jelen, E.; Mattix, B.; Frankel, B.; Alexis, F.; “Delivery of Non-

toxic Drug Loaded Nanoparticles for Enhancing Brain Cancer Therapy”. SCBIO

Conference, Charleston, (2012).

Mattix, B.; Poole, T.; Casco, M.; Visconti, R.; Simionescu, D.; Simionescu, A.; Alexis, F.

“Spatial Control of Magnetic Nanoparticles Integrated with Cellular Spheroids as Tissue

Engineered Building Blocks”. SCBIO Conference, Charleston, (2012).

Moore, T.; Podila, R.; Rao, A.; Alexis, F. “Graphene Coated Technology for Biomedical

Implants.” SFB- Clemson University Biomaterials Day, Clemson, (2012).

Casco, M.; Poole, T.; Visconti, R.; Simionescu, D.; Simionescu, A.; Mattix, B.; Alexis, F.

“Spatial Control of Magnetic Nanoparticles Integrated with Cellular Spheroids as Tissue

Engineered Building Blocks.” SFB- Clemson University Biomaterials Day, Clemson,

(2012).

Uvarov, O.; Willi, T.J.; Reese, L.; Pollard, S.; O’Donnell, L.; Horne, D.; Dhulekar, J.;

Frankel, B.; Mattix, B.; Alexis, F. “Effects of Polymeric Nanoparticle Surface Properties

on Interaction with Brain Tumor Environment.” SFB- Clemson University Biomaterials

Day, Clemson, (2012).

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Moore, T.; Mattix, B.; Grimes, S.; Dhulekar, J.; Kraveka, J.; Frankel, B.; Alexis, F.

“Delivery of Non-toxic Drug Loaded Nanoparticles for Enhancing Brain Cancer

Therapy.” SC INBRE Symposium, Columbia, (2013).

Moore, T.; Wang, F.; Morrison, R.; Musgrave, L.; Anker, J.N.; Alexis, F.

“Radioluminescent Polymer Coated Nanoparticles for Imaging Drug Delivery to the

Brain.” SC INBRE Symposium, Columbia, (2013).

Mattix, B.; Uvarov, O.; Pollard, S.; O’Donnell, L.; Park, K.; Horne, D.; Dhulekar, J.;

Kraveka, J.; Frankel, B.; Alexis, F. “Effects of Polymeric Nanoparticle Surface Properties

on Interaction with Brain Tumor Environment for Drug Delivery Applications.” SC

INBRE Symposium, Columbia, (2013).

PRESENTATIONS

Alexis, F., The Road of Academia, SFB-Clemson Biomaterials Day, Clemson University

(07-22-2009).

Alexis, F., Nanotechnology and Biomaterials, Summer Science Engineering and

Architecture educational program (SSEEA), Clemson University (08-07-2009).

Alexis, F., Targeted Nanoparticles for Drug Delivery, Clemson University Nanomaterial

Group, Clemson University (08-12-2009).

Alexis, F., Targeted Nanoparticles for Drug Delivery, Clemson University Nanomaterial

Group, Clemson University (08-12-2009).

Alexis, F., Targeted Polymeric Nanoparticles for Drug Delivery Applications, School of

Materials Science, Nanyang Technological University (05-25-2010).

Alexis, F., Biomedical research and Technologies at Clemson University, School of

Materials Science, Nanyang Technological University (05-24-2010).

Alexis, F., Targeted Nanoparticles for Drug Delivery, Institute of Environmental

Toxicology, Clemson University (02-16-2010).

Alexis, F., Nanoparticle Drug Delivery Systems for Therapeutic Applications,

Department of Regenerative Medicine, Medical University of South Carolina (12-13-

2010).

Alexis, F., Targeted Nanoparticles for Drug Delivery, Neuroscience Grand Round,

Department of Neuroscience, Medical University of South Carolina (03-07-2010).

Alexis, F., Engineered Nanotechnologies for Biomedical Applications, School of

Materials Science, Nanyang Technological University (06-30-2011).

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Alexis, F., Engineered Nanotechnologies for Medical Applications, Department of

Biological Sciences, Clemson University (11-14-2011).

Alexis, F., Engineered Nanotechnologies for Medical Applications, Department of

Pharmacology and Toxicology, East Carolina University (11-17-2012).

Alexis, F., Assembly and Maturation of Engineered Linear Blood Vessels Using

Magnetic Cellular Spheroids, SC Project for Organ Biofabrication Scientific Symposium,

Columbia (02-10-2012).

Alexis, F.; “Polymer Coated CNTs to Safely Delivery Drugs”. Proceedings of the ACS

SERMACS Meeting, Raleigh, (2012).

Alexis, F. “From Inert Nanomaterials to Functional Structures”. NASA Ames Research

Center, San Jose, (2012).

Alexis, F. “Nanoparticle Delivery of Non-Toxic Drugs for Enhancing Brain Cancer

Therapy”. Institute of Applied Neurosciences, Charleston, (2012).

Alexis, F. “Safely Integrating Nanotechnologies With Tissue Engineering”. University of

South Carolina, Columbia, (2012).

Alexis, F. “Safely Integrating Nanotechnologies With Tissue Engineering”. University of

Chulalongkorn, Thailand, (2013).

Alexis, F. “Safely Integrating Nanotechnologies With Tissue Engineering”. Nanyang

Technological University, Singapore, (2013).

Alexis, F. “Drug Delivery and Imaging Technologies Using X-ray”. ICMAT, Singapore,

(2013).

Alexis, F. “Biological Magnetic Cellular Spheroids as Building Blocks for Tissue

Engineering”, University of South Carolina, Columbia, SC.

F. Alexis “Career Panel-Vanderbilt University’s Biomaterials Day”, Vanderbilt

University, Nashville, (2013).

Alexis, F. “Assembly and Maturation of Engineered Blood Vessels Using Magnetic

Cellular Spheroids”, South Carolina EPSCoR/IDeA Conference, Columbia, (2014)

Alexis, F. “Biodegradable and Biocompatible Imaging Agents”, Medical University of

South Carolina; Center for Biomedical Imaging, Charleston, (2014).

Alexis, F. “Safely Integrating Nanotechnologies With Tissue Engineering”. Nanyang

Technological University, 3D Printing Center, Singapore, (2015).

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Alexis, F. “Functionalized Nanoparticles for Specific Removal of Gaseous Pollutants”.

ICMAT, Singapore, (2015).

Alexis, F. “Biodegradable and Biocompatible Imaging Agents”. University of West

Virginia, (2015).

INTELLECTUAL PROPERTY

“X-Ray Excited Optical Materials and Methods for High-Resolution Chemical

Imaging”. Anker, J., Chen, H.; Alexis, F., Utility Patent (2011).

Trademark-"Call Me GloberTM": Under-represented Undergraduate Research Abroad.

Alexis, F., Burg, K. (2012).

Print (Copyright)-“Tissue Engineering on the Dome!” Alexis, F., Burg, K. (2012).

Licensed to Slicedtomato.

“Receptor targeted nanoparticles for enhanced transcytosis mediated drug delivery”

Pridgen, E.; Alexis, F.; Langer, R.; Farokhzad, O. (2013)-Provisional Patent.

“Biodegradable Polyester-Based X-ray Imaging Agents and Methods of Making and

Using Thereof”, Alexis F., Whitehead, D.C., Van Horn, B. (2014)-Provisional Patent.

“Pollutant remediation Using Biodegradable Polymers” D. Whitehead, Alexis, F., (2014)-

Provisional Patent. Five companies have establish licensing interests.

“Novel Anti-inflammatory Nanoparticle Scaffolds for Periodontal Treatment”;

Kirkwood, K.; Alexis, F. (2015)-Provisional Patent.

Prior to Clemson: "Targeted Drug Delivery Using Human IgG Fc Fragment", Alexis, F., Farokhzad, O. C.,

Kuo, T., Pridgen, E., Radovic-Moreno, A., Langer, R., PCT/US2007/85318 (Licensed by

BIND Biosciences and SELECTA Biosciences).

"Poly (Amino Acid)-Targeted Drug Delivery", Alexis, F., Zhang, L., Chan, J., Basto, P.,

Levy-Nissembaum, E., Langer, R., O. Farokhzad, O. C., PCT/US08/05949 (Licensed by

BIND Biosciences).

"Amphiphilic Compound Assisted Polymeric Particles for Targeted Delivery". Zhang, L.,

Radovic-Moreno, A., Gu, F.X., Alexis, F., Langer, R., Farokhzad, O. C.,

PCT/US2008/059480 (Licensed by BIND Biosciences).

"Oligonucleotide Systems for Targeted Intracellular Delivery", Levy-Nissenbaum, E.,

Farokhzad, O. C., Langer, R., Alexis, F., PCT/US2007/017539 (Licensed by BIND

Biosciences).

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"Adjuvant Incorporation in Immunonanotherapeutics", Alexis, F., Iannacone, M., Chi, J.,

Basto, P., Moseman, A., Von Andrian, U., Langer, R., Farokhzad,

O.C.,PCT/US2008/11932 (Licensed by SELECTA Biosciences).

"Nicotine Immunotherapeutics", Von Andrian, U., Farokhzad, O.C., Alexis, F.,

Iannacone, M., Basto, P., Chi, J., Moseman, A., Langer, R., PCT/US2008/428408

(Licensed by SELECTA Biosciences).

"Engineered Antibody and Antibody Fragments for Oriented Conjugation-Method of

Preparation and Uses Thereof", Alexis, F., Aizu, W., Kuo, T., Pridgen, E., Farokhzad,

O.C., Langer, R., (2008), provisional patent.

"Nanoparticle Technology for the Delivery of Multiple Molecules- Methods of

Preparation and Uses Thereof", Pridgen, E., Alexis, F., Westernof, K., Marein, S.,

Bander, N., Kantoff, P., Farokhzad, O.C., Langer, R., (2008) provisional patent.

"Vaccine Nanotechnology", Von Andrian, U., Farokhzad, O.C., Langer, R., Tobias, J.,

Moseman, A., Zhang, L., Basto, P., Iannacone, M., Alexis, F., (2008) (Licensed by

SELECTA Biosciences).

"Targeting of Antigen Presenting Cells with Immunonanotherapeutics", Chi, J., Alexis,

F., Iannacone, M., Moseman, A., Basto, P., Langer, R., Farokhzad, O.C., Von Andrian,

U., PCT/US08/11932. (Licensed by SELECTA Biosciences).

"Immunonanotherapeutics that Provides IgG Humoral Response Without T-Cell

Antigen", Iannacone, M., Alexis, F., Basto, P., Moseman, A., Chi, J Langer, R.,

Farokhzad, O.C., Von Andrian, U., (Licensed by SELECTA Biosciences).

HONORS AND AWARDS

Third place at the Singapore Young Person’s Lecture Competition, Institute of Materials

South East Asia (2004).

Phage Display of Proteins and Peptides Training, Cold Spring Harbor Laboratory (2009)

Most cited article in ChemMedChem (2007)

Most accessed article in Molecular Pharmaceutics (2008-2014)

Cover Art in Particles and Particle Systems Characterization, Vol 30 (2013)

ACS Nano Podcast of an interview with Dr. Anker and Alexis; Episode 67: ACS Nano;

February 2013 "Managing Editor Heather Tierney highlights features and research

content from Volume 7, Issue 2. In this episode we hear about monitoring pH-triggered

drug release using radioluminescent nanocapsules. Featuring an interview with authors

Frank Alexis and Jeffrey Anker."

Listed in a Nature Biotechnology article as Top Translational Junior Faculty in 2013

Frontispiece in Advanced Functional Materials, In Press (2014)

Guest Speaker, Nanyang Technological University, Convocation 2015

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SPONSORED RESEARCH

“IDeA Networks of Biomedical Research Excellence (INBRE)”; National Institute of

Health, Target Faculty, $17,975,442, ($147,122), (2010-2015).

“Anabolic Targeted Bioactive Nanoparticles for Osteroporosis Therapy”; South Carolina

Space Grant Consortium, Principal Investigator; $30,000, ($30,000), (2010-2011)

“Controlled Self Assembly of Novel Magnetic Cell Spheroids for the Fabrication and

Maturation of Linear Blood Vessels”; American Heart Association, Principal

Investigator, $152,406, ($133,526), (2012-2014).

“Biodegradable Lactide Nanoparticles for the Destruction of Malodorous Organics”;

Animal Co-Products Research and Education Center, Co-Principal Investigator,

$50,000, ($8,000), (2012-2013).

“Controlled Assembly and Maturation of Linear Blood Vessels”, SC EPSCoR/IDeA-

GEAR, National Science Foundation, Principal Investigator, 40,000, ($40,000), (2012-

2013).

“Biodegradable Lactide Nanoparticles for the Destruction of Malodorous Organics”;

Animal Co-Products Research and Education Center, Co-Principal Investigator,

$30,000, ($5,000), (2013-2014).

“Biodegradable Lactide Nanoparticles for the Destruction of Malodorous Organics”;

Animal Co-Products Research and Education Center, Co-Principal Investigator,

$70,000, ($14,000), (2014-2015).

“Novel Anti-Inflammatory Nanoparticle Scaffolds for Periodontal Treatment”;

International Association for Dental Research-GSK Innovation in Oral Care Awards, Co-

Principal Investigator, $80,000, ($30,000), (2014-2015).

“IRES: Call Me Glober-Under-Represented Undergraduate Bioengineering Research in

Singapore”; National Science Foundation, Principal Investigator, $220,000, (2015-2018).

“Lactide Nanoparticles for the Remediation of Rendering Malodorants”; Animal Co-

Products Research and Education Center, Co-Principal Investigator, $70,000, ($30,000),

(2015-2016).

“Accessing Kilogram-Scale Quantities of Functional Nanoparticles for the Remediation

of Industrial Environmental Contaminants”, Clemson University-Technology Maturation

Grant Award, Co-Principal Investigator, 70,000, ($30,000), (2015-2016).

“Immune Reactivation and Apoptosis Induction in Breast Cancer with Bifunctional

Fusion Proteins Using Nanotechnology”, Greenville Health System, Co-Principal

Investigator, 20,000, ($4,000), (2015-2016).

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“Biodegradable X-ray Contrast Polymeric Nanoparticle for Deep Tissue Imaging of Oral

Cancer Tumors”, Center for Oral Health Research (COHR) Pilot & Feasibility Project

Program Award, National Institute of Health, Co-Principal Investigator, 30,000,

($10,000), (2015-2016).

OTHER SPONSORED ACTIVITY Symposium Award, Society For Biomaterials, $5200, (2011-2012).

Equipment grant, National Science Foundation, $683,437.00, (2011-2014).

Travel Award, SCNASA-EPSCoR, $3,750, (2012-2013).

GRADUATE STUDENT ADVISING

Doctoral Graduates

Graduated: N=4 PhD students

Moore, T. “Development of Novel Theranostic Nanomaterials”, (Graduated, 8/2013).

Mattix, B “Integrating Nanomaterials in Tissue Engineering”, (Graduated, 8/2013).

Olsen, T. “Maturation of Tissue Engineered Blood Vessels”, (Graduated, 05/2015).

Alexander, A. “siRNA Delivery to Treat Head and Neck Cancer”, (Graduated 07/2015).

Current: N=2

Guerra, F. “Biodegradable Lactide Nanoparticles for the Destruction of Malodorous Organics”,

05/2017, (Major Advisor).

Casco M. “ Magnetic Cellular Spheroids:”, 05/2017, (Major Advisor)

Masters Graduates

Graduated: N=4 MS students

Jelen, E. “Drug Delivery to the Bone”, (Graduated, 8/2012).

Willi, T.J. “Synthesis of Novel Polymer-Drug Bioconjugates”, (Graduated, 12/2012).

DeCroes, O. “Targeted Drug Delivery for Glioblastoma Therapy”, (Graduated, 8/2014)

Dhulekar, J. “Drug Delivery for Neuroblastoma Therapy”, (Graduated, 8/2014)

TEACHING

Undergraduate Courses Taught

Co-Instructor:

CME241L, Metrics Laboratory, F09, S10

BIOE401, Senior Biomedical Design, S10

BIOE201, Introduction to Biomedical Science, F10, F11, F12, F13, F14

BIO491, Research in BIOE, F09, S10, F10, F11, S11, F12, S12, S13, F13, S14, F14

BIOH491, Honors Research in BIOE, F09, S10, F10, F11, S11, F12, S12, S13, F13, S14,

F14

New Course Development

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BIOE449, Introduction to Drug Delivery Systems, S11, S12, S13, S14, S15

BIOE460, Singapore Summer Research, Su11, Su12, Su13, Su14, Su15

BIOE460, Thailand Summer Research, Su14, Su15

Graduate Courses Taught

Instructor:

BG6001 (SCBE, NTU), Advanced Biomaterials, F15

UNIVERSITY AND PUBLIC SERVICE

Committees

Department: Member, ABET (2009-2011)

Member: Study Abroad Programs (2010- )

Chair: Page Morton Hunter Seminar Series (2010-)

Chair: C. Dayton Riddle Seminar Series (2012)

Member: Student Award (2012-2014)

Chair: Quality Enhancement Plan-Critical Thinking (2013-)

University: Member: Eportfolio assessment (2012)

Member: Quality Enhancement Plan (2012-)

Member: ACC Inter-Institutional Academic Collaborative (2013-)

Member: Intellectual Property Committee (2013-)

Other Service

ETS Proficiency Profile /Measure of Academic Proficiency & Progress (MAPP) (2010)

Phonathon, Bioengineering, (2010)

ETS Proficiency Profile /Measure of Academic Proficiency & Progress (MAPP) (2011)

Arizona State University-Nanotechnology and Society Survey (2011)