Development of Collagen Based Drug Delivery

Systems

Ivy KanungoChemical Lab

Background Information

Drug Delivery Systems

Biomaterials

Collagen

Current Drug Delivery Systems

Problems Associated with Collagen based Drug

Delivery

Aim and Objective

Design Constraints

Plan of Work

Presentation Outline

Drug delivery is the method or process of

administering a pharmaceutical compound to

achieve a therapeutic effect in humans

Drug Delivery

Intestinal

Intravenous/

Intraarterial

Intramuscular/

Subcutaneous

Oral

Buccal / Sublingual

Routes of Drug Administration

Rectal

Nasal

Pulmonary

Vaginal

Intrauterine

Transdermal

Ocular

Methods of Drug Delivery

Release rate dictated by the needs of the

body over the period of treatment

Constant, 0-order (clear PKPD)

Channel the drug to the active site, cell,

tissue, organ (drug targeting)

“No such DDS exists which combines

ABOVE …!!!”

Ideal Drug Delivery System

Continuous maintenance of drug levels in

therapeutically desirable range

Potentially decreased amount of drug

needed

Decreased amount of dosage and possibly

less invasive dosing

Reduction of harmful side effects due to

targeted delivery to a particular site

Improved drug delivery include

Sustain drug action at a predetermined rate by

maintaining a relatively constant, effective drug

level in the body with concomitant minimization

of undesirable side effects associated with a

sawtooth kinetic pattern

Localize drug action by spatial placement of a

controlled release system (usually rate

controlled) adjacent to or in the diseased tissue

or organ

Controlled Delivery Attempts

Target drug action by using carriers

to deliver drugs to a particular

“target” cell type

Targeted Drug Delivery

Drug Release Profile

Plasma drug

concentration-profiles for

conventional tablet or

capsule formulation, a

sustained release

formulation, and a zero-

order controlled release

formulation

Concentration

Solubility

Molecular weight

Chemical stability

Physical stability

Protein binding capability

Physicochemical Properties of a Drug Influencing Design and Performance

Duration of action

Safety

Side effects

Margin of safety

Role of disease state

Biological Characteristics of a Drug Influencing Design and Performance

Biomaterials

BioCompatibilty

Biodegradability

Issues to consider:

Viability

Placement

Size of the carrier required

Inherent properties of the drugs i.e. aqueous

solubility or stability

Surface characteristics i.e. charge and permeability

Degree of biocompatibility, biodegradability and

toxicity

Drug release profile required

Routes of application of drugs

Antigenicity of the final product

Factors Influencing the Selection of the Carrier Material

Development of collagen based

targeted drug delivery for sustained

release

Aim

Chemical modification of collagen

without affecting its triple helical

conformation

Development of drug entrapped

collagen based biomaterials for

sustained release profile

Objective

Collagen: Fibrous Protein

StabilizingInter-strandH-bonds

Gly-Pro-HyPro Repeat

Collagen as a carrier for drug delivery

A three dimensional structure which works

as a natural distance barrier between the

drug is incorporated into the matrix and the

surroundings environment

A network which enhances cell penetration

and new tissue generation

Adjustable bio degradability and bio

resorbability by cross linking

Good resistance and tensile properties

Compatible with synthetic polymers

High water absorbability

Partial open porosity

Partial close porosity

Tertiary release of the drugs

Collagen based drug delivery

Sponge or Film

Hydrogel mediated drug delivery

Colloidal drug delivery

Limitations

Sponge or film can be used for the treatment

of the incision of the outer part of the

body

The quantity and homogeneity of drug

loading into hydrogels

Colloidal based delivery system faces

dispersion and stability problem because of

their strong cohesiveness and high surface

areas

Better Drug entrapment

Targeted delivery

Inexpensive

Sterile

Biocompatible

Sustained Delivery Profile

Scaled up

Design Constraints

Goal: Design Autonomous Nano Medical Systems

Definition: Self-guiding, adaptive,

multicomponent systems on the nanoscale for

diagnostic and therapeutic prevention or

treatment of disease

Value: “smart” nanomedical systems can deal

with changing conditions, are error-correcting,

and can provide proper dose of therapeutic

response on a cell-by-cell basis

Why nanoparticles are desired for drug delivery system?

Questions?

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YY Y Y Cell targeting and

entry

Intracellular targeting

Biomolecular sensing

Gene/drug delivery

Concept: Smart Targeted, Programmed Sequence of Events, Nanomedicine Systems with Biomolecular Sensors for Control of Gene/Drug Delivery within Single Cells

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Y

Biomolecular sensors

Challenges: Optimal Drug Delivery to the Single Cell

Changing of collagen struture and shape

without affecting its amino acids sequences

Use and selection of crosslinking agent

Loading of drugs

Potential Solution: Delivery of a drug

manufacturing (in-situ) factory, not a drug

The Future

…….is full of

surprises

and

unintended

consequence

s