collaborative research on ageing in europe internat … · renato mantegazza, inncb, milan epilepsy...

7
COOPERATION COURAGE in Europe COLLABORATIVE RESEARCH ON AGEING IN EUROPE COURAGE IN EUROPE PROJECT WWW.COURAGEPROJECT.EU Matilde Leonardi Project Coordinator INTERNATIONAL COURAGE IN EUROPE CONFERENCE AND SATELLITE SYMPOSIUM 27-28-29 November 2012 Palazzo delle Stelline, Milan, Italy COURAGE IN EUROPE Partners

Upload: lekiet

Post on 10-Sep-2018

216 views

Category:

Documents


0 download

TRANSCRIPT

Page 1: Collaborative researCh on ageing in europe Internat … · renato mantegaZZa, INNCB, Milan epilepsy in the old age silvana FranCesChetti, INNCB, Milan antiepileptic therapy in the

COOPERATION

COURAGEin Europe

Collaborat ive researCh on age ing in europeCOURAGE IN EUROPE PROJECT

www.CourageprojeCt.eu

Matilde LeonardiProject Coordinator

InternatIonal COURAGE in EUROpEConferenCe and SatellIte SympoSIum

27-28-29 November 2012 Palazzo delle Stelline, Milan, Italy

COURAGE IN EUROPE Partners

Page 2: Collaborative researCh on ageing in europe Internat … · renato mantegaZZa, INNCB, Milan epilepsy in the old age silvana FranCesChetti, INNCB, Milan antiepileptic therapy in the

CO

UR

AG

E I

N E

UR

OP

E S

ATEL

LITE

SYM

POSI

UM

TUE

sd

Ay,

27

NO

vE

mb

ER

20

12

09.00 -10.00 REGistRAtiOn Of pARtiCipAnts

10.00-10.15 OpEninG And WElCOmE tO pARtiCipAntsalberto guglielmo, President, Fondazione IRCCS Istituto Neurologico Carlo Bestapierluigi Zeli, Director General, Fondazione IRCCS Istituto Neurologico Carlo BestaFerdinando Cornelio, Scientific Director, Fondazione IRCCS Istituto Neurologico Carlo Bestamario melaZZini, Regional Health Minister, Regione Lombardiamassimo CasCiello, Director General of Health and Biomedical Research, Ministry of Health

10.15-11.15 ReseaRch on ageing and The euRopean yeaR foR acTive and healThy ageingChairperson: Ferdinando Cornelio, INNCB, Milan

the european year for active and healthy ageingjorge pinto antunes, DG SANCO, European Commission, Brussels

the european year for active and healthy ageing – the italian initiativesannamaria mataraZZo, Presidency of Council of Ministries, Rome

the european innovation partnership on active and healthy ageingsergio peCorelli, AIFA, Rome

ageing and burden of neurological diseases: ageing in europe and the Courage in europe projectmatilde leonardi, INNCB, Courage in Europe project Coordinator, Milan

11.15-12.15 neuRological diseases wiTh onseT in eldeRly populaTion Chairperson: gaetano guglielmi, Ministry of Health, Rome

neuroepidemiology: living longer with neurological diseasesgraZiella Filippini, INNCB, Milan

parkinson’s disease and other movement disordersalberto albanese, INNCB, Milan

COOPERATION

COURAGEin Europe

alzheimer’s disease and other degenerative diseasespietro tirabosChi, INNCB, Milan

stroke and ageing of populationmaria rita Carriero, INNCB, Milan

12.15-12.45 inviTed lecTuRe: socieTal challenges in euRope and bRain disoRdeRsmary baker, European Brain Council, BrusselsIntroduced by Matilde Leonardi

12.45-14.15 Lunch

14.15-15.30 ageing wiTh neuRological diseases wiTh onseT in adulThoodChairperson: adriana maggi, University of Milan

migraine and other headaches in old peopledomeniCo d’amiCo, INNCB, Milan

neuropathic pain in the elderlygiuseppe lauria, INNCB, Milan

neuroimmunological diseases and ageingrenato mantegaZZa, INNCB, Milan

epilepsy in the old agesilvana FranCesChetti, INNCB, Milan

antiepileptic therapy in the elderlyroberto spreaFiCo, INNCB, Milan

CO

UR

AG

E I

N E

UR

OP

E S

ATEL

LITE

SYM

POSI

UM

TU

Es

dA

y, 2

7 N

Ov

Em

bE

R 2

01

2

COOPERATION

COURAGEin Europe

www.CourageprojeCt.euwww.CourageprojeCt.eu

buRden of neuRological disoRdeRs, ageing and disabiliTy

Page 3: Collaborative researCh on ageing in europe Internat … · renato mantegaZZa, INNCB, Milan epilepsy in the old age silvana FranCesChetti, INNCB, Milan antiepileptic therapy in the

COOPERATION

COURAGEin Europe

15.30- 16.15 neuRogeneTics and RaRe diseases in ageingChairperson: andrea martinuZZi, MEDEA, Conegliano

genetic profiles of neurological diseases in ageing populationsFranCo taroni, INNCB, Milan

rare neurological diseases and ageingdavide pareyson, INNCB, Milan

disorders of consciousness in the elderly matilde leonardi, INNCB, Milan

16.15-16.30 COffEE bREAk

16.30-17.45 neuRological diseases, neuRoimaging and suRgical pRoceduRes in The eldeRlyChairperson: Carlo Ferrarese, University of Milan-Bicocca

neuroimaging in ageing populationsmaria graZia bruZZone, INNCB, Milan

Functional mri in the early and differential diagnosis of dementias: some novel ideasludoviCo minati, INNCB, Milan

neuro-oncological diseases in ageinggaetano FinoCChiaro, INNCB, Milan

radiotherapy of glioblastoma in the elderlylaura Fariselli, INNCB, Milan

surgery of neurological conditions in the elderlyFranCesCo dimeCo, INNCB, Milan

17.45 cLosing of couRAgE sAtELLitE symposium

CO

UR

AG

E I

N E

UR

OP

E S

ATEL

LITE

SYM

POSI

UM

TU

Es

dA

y, 2

7 N

Ov

Em

bE

R 2

01

2 spE AkER s And CHAiR s:

alberto albaneseDirector, Movement Disorders Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta (INNCB),Professor of Neurology, Catholic University of Milan, Italy

jorge pinto antunes Innovation for Health and Consumers,DG Health and Consumers, European Commission, Brussels, Belgium

mary baker President, European Brain Council, Brussels, Belgium

maria graZia bruZZoneDirector, Neuroradiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta (INNCB), Milan, Italy

massimo CasCielloDirector General of Health and Biomedical Research, Ministry of Health, Rome, Italy

maria rita CarrieroCerebrovascular Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta (INNCB), Milan, Italy

Ferdinando CornelioScientific Director, Fondazione IRCCS Istituto Neurologico Carlo Besta (INNCB), Milan, Italy

domeniCo d’amiCoHeadache Unit, Fondazione IRCCS Istituto Neu-rologico Carlo Besta (INNCB), Milan, Italy

FranCesCo dimeCo,Director, Department of Neurosurgery and 1st Di-vision of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta (INNCB), Milan, Italy

laura FariselliDirector, Radiotherapy Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta (INNCB), Milan, Italy

www.CourageprojeCt.eu www.CourageprojeCt.eu

Carlo FerrareseDirector, Department of Neurology and Neu-rology Residency School, University of Milano Bicocca, Milan, Italy

graZiella FilippiniDirector, Neuroepidemiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta (INNCB), Milan, Italy

gaetano FinoCChiaroDirector, Molecular Neuro-oncology Unit, Fon-dazione IRCCS Istituto Neurologico Carlo Besta (INNCB), Milan, Italy

silvana FranCesChettiDirector, Neurophysiology and Epileptology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta (INNCB), Milan, Italy alberto guglielmoPresident, Fondazione IRCCS Istituto Neurologico Carlo Besta, (INNCB), Milan, Italy

gaetano guglielmiDirector, Biomedical research Italian Research Hospitals, Ministry of Health, Rome, Italy

giuseppe lauriaDirector, Day Hospital Departmental Unit, Head, Skin biopsy, peripheral Nerve, and Neuropathic Centre Fondazione IRCCS Istituto Neurologico Carlo Besta (INNCB), Milan, Italy

matilde leonardiHead, Neurology, Public Health and Disability Departmental Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta (INNCB), Milan, Italy

adriana maggiDirector, Center of Excellence on Neurodegene-rative diseases, University of Milan, Italy

renato mantegaZZaDirector, Neuroimmunology and Neuromuscular Diseases Unit, Fondazione IRCCS Istituto Neu-rologico Carlo Besta (INNCB), Milan, Italy

andrea martinuZZiHead, Conegliano Research Centre, IRCCS E. Medea (MEDEA), Conegliano, Italy

annamaria mataraZZoDepartment of family policies, Presidency of Council of Ministries, Rome

mario melaZZiniRegional Health Minister, Regione Lombardia, Milan, Italy

ludoviCo minatiScientific Department, Fondazione IRCCS Istitu-to Neurologico Carlo Besta (INNCB), Milan, Italy

davide pareysonHead, Central and Peripheral Degenerative Neuropathies Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, (INNCB), Milan, Italy

sergio peCorelliRector, University of Brescia,President of Italian Medicines Agency (AIFA), Rome, ItalyMember of European Innovation Partnership on Active and Healthy Ageing

roberto spreaFiCoDirector, Clinical Experimental Neurophysiology and Epileptology Unit, Fondazione IRCCS Istitu-to Neurologico Carlo Besta (INNCB), Milan, Italy

FranCo taroniDirector, Unit of Genetics of Neurodegenerative and Metabolic Diseases, Fondazione IRCCS Istituto Neurologico Carlo Besta (INNCB), Milan, Italy

pietro tirabosChiNeuropathology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta (INNCB), Milan, Italy

pierluigi ZeliDirector General, Fondazione IRCCS Istituto Neurologico Carlo Besta (INNCB), Milan, Italy

Page 4: Collaborative researCh on ageing in europe Internat … · renato mantegaZZa, INNCB, Milan epilepsy in the old age silvana FranCesChetti, INNCB, Milan antiepileptic therapy in the

COOPERATION

COURAGEin Europe

08.00 – 09.00 REGistRAtiOn Of pARtiCipAnts

9.00 – 9.30 WElCOmE alberto guglielmo, President, Fondazione IRCCS Istituto Neurologico Carlo Besta (INNCB)pierluigi Zeli, Director General, Fondazione IRCCS Istituto Neurologico Carlo Besta (INNCB)Ferdinando Cornelio, Scientific Director, Fondazione IRCCS Istituto Neurologico Carlo Besta (INNCB) matilde leonardi, Fondazione IRCCS Istituto Neurologico Carlo Besta (INNCB)roberto Formigoni * President, Regione Lombardia, Milanrenato balduZZi * Minister of Health, Rome

9.30 – 10.15 couRage in euRope pRojecT’s aims and main ResulTs matilde leonardi, INNCB, Courage in Europe Coordinator, Milan, Italy

10.15 – 11.15 ageing, disabiliTy and ReseaRchChairperson: matilde leonardi, INNCB, Milan

ageing research in Fp7 and Courage project: an overview, towards horizon 2020 barbara kerstiens, DG Research, European Commission, Brussels, Belgium

disability and ageing policies in europe in light of eu strategy on disability and un ConventioninmaCulada plaCenCia porrero, DG Justice, European Commission, Brussels, Belgium

Courage european data and worldwide sage results: indications for policy developmentsomnath Chatterji, WHO, COURAGE in Europe P.I., Geneva, Switzerland

Courage protocol for ageing and disability surveys in europejerome biCkenbaCh, COURAGE in Europe Advisory Board, Switzerland/Canada

11.15 – 11.30 coffEE bREAk

* invited

CO

UR

AG

E I

N E

UR

OP

E IN

TERN

ATIO

NAL

CO

NfE

REN

CE

WEd

NEs

dAy

, 28

NO

vEm

bER

201

2ageing in euRope: disabiliTy, well-being and qualiTy of life and The couRage pRoTocol 11.30 – 13.00

fRom ageing and disabiliTy To The couRage in euRope pRojecT (paRT i): meThodology, analysis, couRage in euRope pRoTocol and whoqol-ageChairperson: somnath Chatterji, WHO, COURAGE in Europe P.I., Geneva, Switzerland

Courage protocol: importance of a tool for data collection in ageing and disability studiesalessandro solipaCa, COURAGE in Europe Advisory Board, Italy

sampling strategies in Courage in europe projectbeatriZ olaya guZman, PSSJD, COURAGE in Europe, Barcelona, Spainmaria viCtoria moneta, PSSJD, COURAGE in Europe, Barcelona, Spain

methodology and data analysis in Courage projectalessandra andreotti, Explora Centre, COURAGE in Europe, Padua, Italymaria graZia FranCo, Explora Centre, COURAGE in Europe, Padua, Italy

socio-demographic information in Finland, poland and spainnadia miniCuCi, COURAGE in Europe Advisory Board, Italy

the whoQol-age instrument for international studies on quality of life and Courage datamiCk power, COURAGE in Europe Advisory Board, U.K.

13.00 – 14.30 Lunch

14.30 – 16.00 fRom ageing and disabiliTy To The couRage in euRope pRojecT (paRT ii): mobiliTy and cogniTive funcTioning, well-beingChairperson: antonio lobo satué, University of Zaragoza, Spain

mobility Functioning in Finland, poland and spainseppo koskinen, THL, COURAGE in Europe P.I., Helsinki, Finland

Cognitive Functioning and mental health outcomes josep maria haro, PSSJD, COURAGE in Europe P.I., Barcelona, Spain

CO

UR

AG

E I

N E

UR

OP

E IN

TERN

ATIO

NAL

CO

NfE

REN

CE

WEd

NEs

dAy

, 28

NO

vEm

bER

201

2

COOPERATION

COURAGEin Europe

www.CourageprojeCt.euwww.CourageprojeCt.eu

Page 5: Collaborative researCh on ageing in europe Internat … · renato mantegaZZa, INNCB, Milan epilepsy in the old age silvana FranCesChetti, INNCB, Milan antiepileptic therapy in the

COOPERATION

COURAGEin Europe

CO

UR

AG

E I

N E

UR

OP

E f

INAL

CO

NfE

REN

CE

WEd

NEs

dAy

, 28

NO

vEm

bER

201

2well-being in Courage in europe project: results from Finland, poland, spainmarta miret, UAM, COURAGE in Europe, Madrid, Spain

results on Quality of life and well-being from sage projectnirmala naidoo, SAGE project, WHO, Geneva, Switzerland

16.00 – 16.30 inviTed lecTuRe: euRopean and inTeRnaTional well-being iniTiaTives and ReseaRchritu sadana, WHO, Geneva, Switzerland

16.30 – 16.45 coffEE bREAk

16.45 – 18.00 social neTwoRks and enviRonmenTal facToRs as deTeRminanTs of healTh and disabiliTy in ageing Chairperson: tomasZ grodZiCki, Jagellonian University,(UJ), Krakow, Poland

social networks: Courage results beata tobiasZ-adamCZyk, UJ, COURAGE in Europe P.I., Krakow, Polandalexander galas, UJ, COURAGE in Europe, Krakow, Poland kasia ZawisZa, UJ, COURAGE in Europe, Krakow, Poland

result of effects of built environment on ageing: the Cbe – Courage built environment toolpaola buCCiarelli, COURAGE in Europe Advisory Board, Milan alberto raggi, INNCB, COURAGE in Europe, Milanrui Quintas, INNCB, COURAGE in Europe, Milan

18.00 cLosing of 1st DAy

www.CourageprojeCt.euwww.CourageprojeCt.eu CO

UR

AG

E I

N E

UR

OP

E IN

TERN

ATIO

NAL

CO

NfE

REN

CE

ThU

Rs

dAy

, 29

NO

vEm

bER

201

2

deTeRminanTs of healTh and disabiliTy in ageing: ReseaRch and policy developmenT08.00 – 09.00 REGistRAtiOn Of pARtiCipAnts

9.00 – 11.00 ageing, healThy ageing and disabiliTy in euRopeChairperson: matilde leonardi, INNCB, Milan

european projects on ageingmartin bobak, CHANCES Project, United Kingdomsimone CroeZen, SHARE Project, The NetherlandsFranCesCo barbabella, FUTURAGE Project, Italysylke andreas, MENTDIS_ICF65+ Project, GermanyleoCadio rodrigueZ manas, FRAILOMIC Project, Spain

monitoring health and disability in an ageing europedorly j. h. deeg, COURAGE in Europe Advisory Board, The Netherlands

disability and ageing: long-term care for older people and eu policies on disability and ageingdavid mcdaid, LSE, London, United Kingdom

who’s Contribution for healthy ageingjohn beard, WHO, Geneva, Switzerland

COOPERATION

COURAGEin Europe

Page 6: Collaborative researCh on ageing in europe Internat … · renato mantegaZZa, INNCB, Milan epilepsy in the old age silvana FranCesChetti, INNCB, Milan antiepileptic therapy in the

COOPERATION

COURAGEin Europe

CO

UR

AG

E I

N E

UR

OP

E IN

TERN

ATIO

NAL

CO

NfE

REN

CE

ThU

Rs

dAy

, 29

NO

vEm

bER

201

211.00 – 11.30 coffEE bREAk

11.30 – 13.00 Round TableThe couRage pRoTocol foR healTh and disabiliTy in ageing: ReseaRch, policy and civil socieTy TogeTheR To define fuTuRe diRecTions foR an ageing euRopeChairperson: jerome biCkenbaCh, COURAGE in Europe Advisory Board

angela CluZel, AGE Platform in Europe, Brussels, Belgiumbarbara kerstiens, DG Research, Brussels, Belgiumsomnath Chatterji, WHO, COURAGE in Europe P.I., Geneva, Switzerlandminna-liisa luoma, THL, COURAGE in Europe Partner, Helsinki, Finland josep maria haro, PSSJD, COURAGE in Europe P.I., Barcelona, Spainjose luis ayuso-mateos, UAM, COURAGE in Europe P.I., Madrid, Spainbeata tobiasZ-adamCZyk, UJ, COURAGE in Europe P.I., Krakow, Polandmatilde leonardi, INNCB, COURAGE in Europe Coordinator, Milan, Italy

13.00 cLosing matilde leonardi

www.CourageprojeCt.euwww.CourageprojeCt.eu

spE AkER s And CHAiR s:

sylke andreas MentDis_ICF65+ Project, Institute of Medical Psycho-logy, University Medical Centre Hamburg-Eppendorf, Germany

alessandra andreotti Explora Centre, COURAGE in Europe, Padua, Italy

jose luis ayuso-mateosDirector, Department of Psychiatry, Universidad Autónoma de Madrid (UAM), Madrid, Spain

renato balduZZiMinister of Health, Rome, Italy

FranCesCo barbabella FUTURAGE Project, National Institute of Health and Science on Aging, Ancona, Italy

john beardDirector of Department of Ageing and Life Course, World Health Organization, Geneva, Switzerland

jerome biCkenbaChDisability Policy Unit Head, Swiss Paraplegic Research Nottwil, SwitzerlandChair of COURAGE in Europe Advisory Board

martin bobakCHANCES Project, University College London (UCL), Department of Epidemiology and Public Health, London, UK

paola buCCiarelliArchitect 4inclusion – Supporting Human Diversity Through Inclusive Design, Milan, ItalyCOURAGE in Europe Advisory Board

somnath ChatterjiTeam Leader Multi-Country Studies Unit, World Health Organization, Geneva, Switzerland

Ferdinando CornelioScientific Director, Fondazione IRCCS Istituto Neurolo-gico Carlo Besta (INNCB), Milan, Italy

angela CluZelChair of Health and Social Services Expert Group, AGE Platform in Europe, Brussels, Belgium

simone CroeZenSHARE Project, Erasmus Medical Centre, Department of Public Health, Rotterdam, The Netherlands

dorly j. h. deeg VU University of Amsterdam, EMGO Institute of Health and Care Research, Amsterdam, The Nether-lands, COURAGE in Europe Advisory Board

roberto FormigoniPresident, Regione Lombardia, Milan, Italy

maria graZia FranCoExplora Centre, COURAGE in EuropePadua, Italy

alexander galasJagellonian University Medical College (UJ), Krakow, Poland

tomasZ grodZiCkiDean, Jagiellonian University Medical College(UJ), Krakow, Poland

alberto guglielmoPresident, Fondazione IRCCS Istituto Neurologico Carlo Besta, (INNCB), Milan, Italy

josep maria haroResearch Director, Parc Sanitari Sant Joan de Déu (PSSJD), Barcelona, Spain

barbara kerstiensHead of Sector Public Health, DG Research and Innovation – Health, European Commission,Brussels, Belgium

seppo koskinen Head of Public Health Research Unit, National Institu-te for Health and Welfare (THL), Helsinki, Finland

matilde leonardiHead, Neurology, Public Health and Disability Departmental Unit, Fondazione IRCCS Istituto Neuro-logico Carlo Besta (INNCB), Milan, Italy

antonio lobo satuéProfessor and Chairman Deparment of Psychiatry Hospital Clinico Universitario and University of Zaragoza, Spain

minna-liisa luomaNational Institute for Health and Welfare (THL), Helsinki, Finland

david mCdaidLSE Health and Social Care, European Observatory on Health Systems and Policies, London School of economics and Political Science, London, UK

nadia miniCuCi,National Council Research, Institute of Neuroscience, Padua, Italy, COURAGE in Europe Advisory Board

marta miretUniversidad Autónoma de Madrid (UAM), Madrid, Spain

maria viCtoria monetaParc Sanitari Sant Joan de Déu (PSSJD), Barcelona, Spain

nirmala naidooMulti-Country Studies Unit, World Health Organiza-tion, Geneva, Switzerland

beatriZ olaya guZmánParc Sanitari Sant Joan de Déu (PSSJD), Barcelona, Spain

inmaCulada plaCenCia porreroDeputy Head, Unit “Rights of Persons with Disabili-ties”, DG Justice, European Commission, Brussels

miCk powerProfessor of Clinical Psycology, University of Edinburgh, United Kingdom, COURAGE in Europe Advisory Board

rui QuintasFondazione IRCCS Istituto Neurologico Carlo Besta (INNCB), Milan, Italy

alberto raggiFondazione IRCCS Istituto Neurologico Carlo Besta (INNCB) Milan, Italy

leoCadio rodrigueZ manasFRAILOMIC Project, Department of Geriatrics at Hospi-tal Universitário de Getafe, Madrid, Spain

ritu sadanaGender, Equity and Human Right, Family, Women and Children’s ClusterWorld Health Organization, Geneva, Switzerland

alessandro solipaCaItalian Statistical Office (ISTAT), Rome, Italy,COURAGE in Europe Advisory Board

beata tobiasZ-adamCZyJagellonian University Medical College (UJ), Krakow, Poland

kasia ZawisZJagellonian University Medical College (UJ), Krakow, Poland

pierluigi ZeliDirector General, Fondazione IRCCS Istituto Neurolo-gico Carlo Besta (INNCB), Milan, Italy

Page 7: Collaborative researCh on ageing in europe Internat … · renato mantegaZZa, INNCB, Milan epilepsy in the old age silvana FranCesChetti, INNCB, Milan antiepileptic therapy in the

INTERNATIONAL COURAGE IN EUROPE CONfERENCE ANd SATELLITE SYMPOSIUM

RegistRation infoRmationDeaDlIne for regIStratIon 19th noveMber 2012

For registration please go to www.CourageprojeCt.eu and fill in the Registration Form

Please send the registration form to:new aurameeting

Attention: Ms Francesca Rossoni - Email [email protected]; fax +39 02 66200418 - Ph +39 02 66203390 - mobile: +39 349 0515101

N.B. Attendance is free, however registration is compulsory due to limited space

COOPERATION

COURAGEin Europe

organizing Committee:

Carla Finocchiaro, Grazia Pagano, Pamela Cammarata, Luca D’Antona,Sibilla Sorrentino

Matilde Leonardi, Anna Moiana, Anita Quatrini, Rui Quintas, Alberto Raggi

scientific Committee:

COOPERATION

COURAGEin Europe

the Courage in europe Consortium

A European Commission project funded within the SeventhFramework Programme Number HEALTH-F2-2009-223071