cobas 4000 analyzer seriesThe two belong together

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cobas brand

Roche Diagnostics introduces the cobas brand as the umbrellafor products used to complete or expand the screening, diagnosticand monitoring applications of the professional laboratory.

cobas brand includes:serum work area with clinical chemisty and immunochemistrydata management and preanalytical solutionsproducts for coagulation analysis and urinalysisinstruments for rapid blood and cardiovascular testingPCR-based applications for virology and womens health testing

1 Operator interface

5 Analytical modules

150 Different assays ava

ilable

cobas modular platform Flexibility you can build on

Todays laboratories are challenged with delivering high stan-dards of laboratory services with fewer resources. They faceconstant pressure to lower operating costs while aspiring togrow their business in new areas. Their concern for patient careis paramount, and they demand only the best in diagnostictesting and services.

Just as every patient requires individualized care, every labo-ratory is unique. Striking the balance between high standardsand efficient operation requires tailor-made solutions. Withcobas modular platform, Roche has developed a platformconcept that delivers individualized solutions based on a com-mon architecture for various workloads and testing require-ments.

cobas 4000 is the second member of the new cobas modularplatform. It offers small workload laboratories a completesolution for clinical chemistry and immunochemistry testing.

Common universal reagent carriers

Simplifies logisticsEfficient use of reagents

Common applications and analytical technologies

Comparable patient resultsCombines routine and innovative testing

Common operator interface

Requires less training Promotes staff flexibility

The cobas modular platform is designed to reduce the com-plexity of laboratory operation and provides efficient andcompatible solutions for network cooperation.

cobas 4000 analyzer seriesThe two belong together

Compact yet powerful

cobas 4000 includes the cobas c 311 analyzer for clinicalchemistry and cobas e 411 analyzer for immunoassays.

The combination of the two analyzers provides true operational integration for small workload laboratories.

Complete serum work area testing

cobas 4000 performs clinical chemistry and immunoassaytesting for laboratories processing 80-200 serum samples/day.

Its menu of over 150 routine and innovative assays satisfiesvirtually all of the testing needs for small workload laboratories.

A capacity of up to 63 combined onboard tests enables fullindication panels for diagnosis and therapy monitoring.

NEW

in 2007

Convenience in operation

cobas reagent packs are always ready to use and highly stable for efficient usage.

Common cobas user interfaces enable users seamless and flexible operation between analyzers.

Online updates and remote service access via cobas e-services expedite service and support.

Confidence in results

Roche/Hitachi in design and manufacture, cobas 4000continues the long tradition of proven reliability.

Electrochemiluminescence (ECL) technology sets high standards of analytical performance and time to result.

One grip handling of reagents

The unique concept of the cobas c packs and cobas e packsallows for convenient reagent handling.

All reagents are ready to use and are closed for protectionfrom external elements.

Reagent stability of up to 3 months once opened guaranteesefficient usage even for esoteric assays.

Over 90% of all reagents require calibration only once per lot. Over 70% of all reagents require a sample volume of less

than 50 microliters.cobas c pack multi enables development channels for user-defined reagent applications.

Loading cobas c pack onto the cobas c 311 analyzer Pippetting reagent from cobas e pack on the cobas e 411 analyzer

cobas 4000 analyzer seriesThe two belong together

cobas c 311 analyzer

Clinical chemistryISE: potassium, sodium, chlorideHomogeneous immunoassaysHbA1c whole blood measurementIntegrated with cobas e-services

Throughput up to 480 tests/hour45 direct access assaysColor touchscreen with mouseContact-free ultrasonic mixingClot detection

NEW

in 2007

cobas e 411 analyzer

Heterogeneous immunoassaysNine minute STAT applicationsCardiac markers including proBNPOver 50 assays for anemia, bone, cancer,hormones and infectious diseasescobas e-services optional

Throughput of up to 88 tests/hour18 direct access assaysCarry-over free disposable tipsClot detection

Three ways to unmatched performance

As the heart of the cobas e 411 analyzer, ECL technologydelivers the unique combination of nine minute STAT appli-cations, high analytical sensitivity and wide measuring rangesfor unparalleled performance in immunochemistry.

Make STATs part of your routine

With cobas 4000's nine minute STAT applications, you canseamless integrate STAT samples into your routine workload.These applications include:

- hCG+- Troponin T 4th Gen.- CK-MB- Myoglobin- PTH*

Faster turnaround-time for these critical parameters willincrease your laboratory's responsiveness to important areasof the hospital such as the Emergency Department andSurgery.

* PTH nine minute application in development for March 2007

High analytical sensitivityenables the use of innovative tests andrequires less sample volume

examples: Troponin T 4th gen. with

cobas 4000 analyzer seriesPreliminary Specifications

System cobas 4000 analyzer series includes two stand-alone analyzers for serum work area testing in small workload laboratories:

cobas c 311 is a fully automated, random access system for clinical chemistry and

homogeneous immunoassay analysis.

cobas e 411 is a fully automated, random access system for heterogeneous

immunoassay analysis. It is available as both a disk system and a rack system.

Test throughput Up to 300 tests/hr. photometric and ISE on cobas c 311Up to 88 tests/hr. on cobas e 411

Type of analyzers cobas c 311: photometric measuring unit including ISEcobas e 411: ECL technology measuring unit

Number of channels Up to 63 channels (reagent slots) in total: Up to 45 channels on cobas c 311

Up to 18 channels on cobas e 411

Available parameters 196 parameters in total: 117 photometric tests, 3 ISE tests, 8 formulas, 3 serum indices on cobas c 311

65 heterogeneous tests with cobas e 411

Sample types Serum, Plasma, Urine, CSF, Whole Blood (HbA1c only)

Sample container types Primary tubes 5-10mL; 16x100, 16x75, 13x100, 13x75mmSample cup 2.5mL

Micro cup cobas c 311 only: 1.5mL

Cups on tube Cup on top of a 16x75/100mm tube

cobas c 311 only: cup on top of one non-standard tube and

false buttom tube

Result integrity Clot detection available on both analyzers Disposable tips on cobas e 411

3 test-specific serum indices on cobas c 311; automatic interference flagging of

results provided by cobas IT 3000 work area manager

Rerun/reflex function Automatic and manual rerun on cobas c 311, manual rerun only on cobas e 411Automatic reflex is supported by both systems, reflex request to be provided by

cobas IT 3000 work area manager or LIS

Regulatory requirements CE, UL, C-UL, CB-report and certificate

COBAS, COBAS C, COBAS E and LIFE NEEDS ANSWERS are trademarks of Roche.

2006 Roche Diagnostics

Roche Diagnostics GmbHD-68298 MannheimGermanywww.roche-diagnostics.com

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