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Supplementary dataContentsFigure 1. Comparison of survival between the intraocular and extraocular groups before
and after January 2011......................................................................................................2
Figure 2. Comparison of survival by laterality grouping before and after January 2011....3
Figure 3. Comparison of survival among chemotherapy groups before and after January
2011.................................................................................................................................. 4
Figure 4. Comparison of survival between the choroid invasion groups before and after
January 2011.....................................................................................................................4
Figure 5. Comparisonn of survival between the optic nerve invasion groups before and
after January 2011............................................................................................................5
Table 1. Correlation between choroid invasion and optic nerve invasion..........................6
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SUPPLEMENTARY FIGURE 1. Comparison of survival between the intraocular andextraocular groups before and after January 2011.Intraocular versus extraocular at initial evaluation
Intraocular versus extraocular with extraocular subgroups
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SUPPLEMENTARY FIGURE 2. Comparison of survival by laterality grouping before and after January 2011
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SUPPLEMENTARY FIGURE 3. Comparison of survival among chemotherapy groups before and after January 2011.
SUPPLEMENTARY FIGURE 4. Comparison of survival between the choroid invasion groups before and after January 2011.
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SUPPLEMENTARY FIGURE 5. Comparison of survival between the optic nerve invasion groups before and after January 2011.
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SUPPLEMENTARY TABLE 1. Correlation between choroid invasion and optic nerve invasion
Systemic Neoadjuvant Chemotherapy
Optic Nerve (ON) Total
No ON invasion Prelaminal
At Lamina
Postlamina premarginal
Surgical margin
Noa,b
Cho
roid
Inva
sion
None Count 16 6 9 1 1 33
% within Choroid 48.5% 18.2% 27.3% 3.0% 3.0% 100.0%
% within Optic Nerve 40.0% 17.1% 21.4% 5.0% 4.5% 20.8%
Minimal Count 18 18 23 8 2 69
% within Choroid 26.1% 26.1% 33.3% 11.6% 2.9% 100.0%
% within Optic Nerve 45.0% 51.4% 54.8% 40.0% 9.1% 43.4%
Massive Count 5 11 8 7 5 36
% within Choroid 13.9% 30.6% 22.2% 19.4% 13.9% 100.0%
% within Optic Nerve 12.5% 31.4% 19.0% 35.0% 22.7% 22.6%
Massive with sclera
Count 1 0 2 4 14 21
% within Choroid 4.8% 0.0% 9.5% 19.0% 66.7% 100.0%
% within Optic Nerve 2.5% 0.0% 4.8% 20.0% 63.6% 13.2%
Tota
l
Count 40 35 42 20 22 159
% within Choroid 25.2% 22.0% 26.4% 12.6% 13.8% 100.0%
% within Optic Nerve 100.0% 100.0% 100.0% 100.0% 100.0% 100.0%
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Yes
Cho
roid
inva
sion
None Count 9 5 4 1 0 19
% within Choroid 47.4% 26.3% 21.1% 5.3% 0.0% 100.0%
% within Optic Nerve 37.5% 23.8% 44.4% 50.0% 0.0% 32.2%
Minimal Count 11 6 2 1 0 20
% within Choroid 55.0% 30.0% 10.0% 5.0% 0.0% 100.0%
% within Optic Nerve 45.8% 28.6% 22.2% 50.0% 0.0% 33.9%
Massive Count 1 3 1 0 1 6
% within Choroid 16.7% 50.0% 16.7% 0.0% 16.7% 100.0%
% within Optic Nerve 4.2% 14.3% 11.1% 0.0% 33.3% 10.2%
Massive with sclera
Count 3 7 2 0 2 14
% within Choroid 21.4% 50.0% 14.3% 0.0% 14.3% 100.0%
% within Optic Nerve 12.5% 33.3% 22.2% 0.0% 66.7% 23.7%
Tota
l e
Count 24 21 9 2 3 59
% within Choroid 40.7% 35.6% 15.3% 3.4% 5.1% 100.0%
% within Optic Nerve 100.0% 100.0% 100.0% 100.0% 100.0% 100.0%
Date Registered and Enucleated
Bef
ore
2011
c,d
Cho
roi
d
None Count 6 4 1 2 1 14
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inva
sion
% within Choroid 42.9% 28.6% 7.1% 14.3% 7.1% 100.0%
% within Optic Nerve 50.0% 66.7% 25.0% 40.0% 25.0% 45.2%
Minimal Count 6 2 3 3 0 14
% within Choroid 42.9% 14.3% 21.4% 21.4% 0.0% 100.0%
% within Optic Nerve 50.0% 33.3% 75.0% 60.0% 0.0% 45.2%
Massive with sclera
Count 0 0 0 0 3 3
% within Choroid 0.0% 0.0% 0.0% 0.0% 100.0% 100.0%
% within Optic Nerve 0.0% 0.0% 0.0% 0.0% 75.0% 9.7%
Tota
l
Count 12 6 4 5 4 31
% within Choroid 38.7% 19.4% 12.9% 16.1% 12.9% 100.0%
% within Optic Nerve 100.0% 100.0% 100.0% 100.0% 100.0% 100.0%
% within Optic Nerve 100.0% 100.0% 100.0% 100.0% 100.0% 100.0%
Afte
r Jan
201
1a†
Cho
roid
None Count 16 6 12 0 0 34
% within Choroid 47.1% 17.6% 35.3% 0.0% 0.0% 100.0%
% within Optic Nerve 36.4% 14.6% 27.3% 0.0% 0.0% 20.6%
Minimal Count 20 20 20 6 2 68
% within Choroid 29.4% 29.4% 29.4% 8.8% 2.9% 100.0%
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% within Optic Nerve 45.5% 48.8% 45.5% 37.5% 10.0% 41.2%
Massive Count 6 12 9 7 6 40
% within Choroid 15.0% 30.0% 22.5% 17.5% 15.0% 100.0%
% within Optic Nerve 13.6% 29.3% 20.5% 43.8% 30.0% 24.2%
Massive with sclera
Count 2 3 3 3 12 23
% within Choroid 8.7% 13.0% 13.0% 13.0% 52.2% 100.0%
% within Optic Nerve 4.5% 7.3% 6.8% 18.8% 60.0% 13.9%
Tota
l
Count 44 41 44 16 20 165
% within Choroid 26.7% 24.8% 26.7% 9.7% 12.1% 100.0%
% within Optic Nerve 100.0% 100.0% 100.0% 100.0% 100.0% 100.0%
aPearson Chi-Square was significant at the 0.001 level. bInterval-by-interval correlations were done using Pearson's R, and ordinal-by-ordinal correlations were done using Spearman. Correlations were significant at the 0.001 level. cPearson Chi-Square was significant at the 0.05 level.dInterval-by-interval correlations done using Pearson's R were significant at the 0.005 level.eData shown are for eyes with full data regarding the presented variables.
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